Biological medicine low-temperature freeze-drying device and use method

Abstract

The invention relates to the technical field of low-temperature freeze-drying devices, and discloses a biological medicine low-temperature freeze-drying device and a using method.The biological medicine low-temperature freeze-drying device comprises a freeze-drying machine, a containing frame is arranged at the top of the freeze-drying machine, a sealing cover is installed at the top of the freeze-drying machine, and pipe bodies are arranged on the side face of the freeze-drying machine and comprise an exhaust pipe and an exhaust pipe; a mechanical valve is arranged, and a tray is connected to the placing frame in a sliding manner; the lowest tray is pushed, the mounting plate is slowly rotated inwards at the same time, after the height of the trays is adjusted to be appropriate, the rubber pads abut against the trays, the limiting effect is achieved, the last but one tray at the bottom is pushed, the steps are repeated, the heights of the multiple trays are adjusted and limited at the same time, and adjustment is completed; the limited tray extrudes the rubber pad to enable the rubber pad to deform, normal rotation of the mounting plate is not affected, and meanwhile the limiting effect on the tray is improved by increasing friction force.

Description

Technical Field

[0001] The present invention relates to the technical field of cryogenic freeze-drying devices, and in particular to a cryogenic freeze-drying device for biomedicine and its usage method. Background Art

[0002] The pharmaceutical industry and the biomedical engineering industry are the two major pillars of the modern pharmaceutical industry. The biomedical industry is jointly composed of the biotechnology industry and the pharmaceutical industry. The definitions and scopes of the biotechnology industry defined by various countries and organizations are very inconsistent, and even the views of different people often vary greatly. When biomedicine is applied in experiments, a cryogenic freeze-drying device is usually used to freeze-dry biomedicine, which can fully protect the characteristics of biomedicine. Cryogenic freeze-drying devices are widely used in the fields of medicine, biological products, food, etc. For example, the collagen cryogenic freeze-drying technology quickly freezes collagen in a low-temperature environment to form a stable ice crystal structure, and then removes water through sublimation in a vacuum environment, so as to dry and preserve it without damaging the collagen structure.

[0003] For example, the freeze-dryer with the model number LC-10N-80A is suitable for cryogenic freeze-drying processing operations in the fields of bioengineering, food industry, material science, and pharmacy. In the field of biological materials, it can perform freeze-drying processing operations including but not limited to medicine and medical materials, such as collagen, protein products, antibiotics, vaccines, blood products, biological samples (cells, tissues, etc.), and enzymes and hormones. In addition, it can also perform freeze-drying processing on temperature-sensitive (high-temperature) water-soluble materials.

[0004] Currently, the spacing between trays on the rack of the cryogenic freeze-drying device for biomedicine in the market is not convenient to adjust during use. The items that can be freeze-dried in the laboratory are restricted, and oversized or overheight items cannot be placed on the trays for processing, resulting in inconvenient use of the cryogenic freeze-drying device and affecting its scope of application. For example, the patent with the Chinese utility model publication number CN220567674U discloses a cryogenic freeze-drying device for biomedical experiments. By setting a movable tray, a support rod, a slider, a screw rod, an anti-slip pad, and a fastening nut, turning the fastening nut in cooperation with the thread on the screw rod, the fastening nut can move left and right on the screw rod, which can drive the anti-slip pad to move left and right. When the fastening nut squeezes the anti-slip pad to closely contact the support rod, the position of the movable tray can be restricted. Conversely, the operator can move the movable tray up and down to a suitable position and then perform the limit. Then, for the spacing between the trays of the rack of the cryogenic freeze-drying device, the operator can make corresponding adjustments according to the size of the actual experimental items to expand the range of experimental items and improve the applicability of the freeze-drying device. However, in actual use, the spacing between multiple trays needs to be adjusted and fixed in sequence, resulting in low adjustment efficiency and inconvenience for the staff to use. Summary of the Invention

[0005] (1) Technical problem to be solved

[0006] In view of the deficiencies of the prior art, the present invention provides a low-temperature freeze-drying device for biological medicine and a method of using the same, which has the advantages of rapid adjustment and rapid fixation, and solves the problem that the existing low-temperature freeze-drying device for biological medicine does not have a good adjustment function.

[0007] (2) Technical solution

[0008] To achieve the above object, the present invention provides the following technical solution: a low-temperature freeze-drying device for biological medicine and a method of using the same, comprising: a freeze-dryer, on the top of which there is a placement rack, a sealing cover is installed on the top of the freeze-dryer, a pipe body is arranged on the side of the freeze-dryer, the pipe body is respectively an air extraction pipe and an exhaust pipe, and a mechanical valve is provided, a tray is slidably connected to the placement rack, a groove one is formed on the placement rack, an installation plate is rotatably connected in the groove one, one side of the installation plate is fixedly connected with a rubber pad, the rubber pad is in close contact with the tray and is in the shape of a right-angled trapezoid, a groove two is formed on the placement rack, the top end of the rubber pad is inserted into the groove two, a fastening bolt one is threadedly connected to the placement rack, a hole body is formed on the installation plate, and one end of the fastening bolt one is inserted into the hole body.

[0009] In some embodiments, the rubber pad is a silicone rubber pad.

[0010] In some embodiments, the length of the groove two is greater than the length of the groove one.

[0011] In some embodiments, a groove three is formed on the placement rack, a plate body is slidably connected in the groove three, a tooth is fixedly connected to the side of the plate body, a card slot is formed on the outside of the tray, the tooth is inserted into the card slot, and a fastening bolt two is threadedly connected to the placement rack.

[0012] In some embodiments, a plurality of fastening bolts two are provided.

[0013] In some embodiments, a limiting plate is slidably connected to the placement rack, one end of the limiting plate is located directly below the fastening bolt one, and the other end is in close contact with the plate body.

[0014] In some embodiments, the limiting plate is in a C shape.

[0015] In some embodiments, the distance between the groove one and the groove three is greater than the diameter of the tray.

[0016] (3) Beneficial effects

[0017] Compared with the prior art, the present invention provides a low-temperature freeze-drying device for biological medicine and a method of using the same, which has the following beneficial effects:

[0018] The present invention pushes the lowermost tray and simultaneously slowly rotates the mounting plate inward. After the height of the tray is adjusted appropriately, the rubber pad abuts against it to play a limiting role. Then, push the second-lowest tray from the bottom and repeat the above steps to achieve simultaneous adjustment and limitation of the heights of multiple trays, completing the adjustment. Moreover, when limiting the second tray, the previously limited trays squeeze the rubber pad, causing the rubber pad to deform. Without affecting the normal rotation of the mounting plate, by increasing the friction force, the limiting effect on the tray is improved. It has the advantages of rapid adjustment and rapid fixation, and solves the problem that the existing low-temperature freeze-drying device for biological medicine does not have a good adjustment function. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 is a schematic structural diagram of the present invention;

[0020] Figure 2 is a three-dimensional structural diagram of the placement rack in the present invention;

[0021] Figure 3 is an internal structural diagram of the placement rack in the present invention;

[0022] Figure 4 is for the present invention Figure 3 a partial enlarged structural diagram of part A in;

[0023] Figure 5 is a structural diagram of the installation position of the limiting plate in the present invention.

[0024] In the figure:

[0025] 10, freeze dryer; 11, placement rack; 12, sealing cover; 13, pipe body; 14, tray;

[0026] 20, first groove; 21, mounting plate; 22, rubber pad; 23, second groove; 24, first fastening bolt; 25, hole body;

[0027] 30, third groove; 31, plate body; 32, teeth; 33, card slot; 34, second fastening bolt;

[0028] 40, limiting plate. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0029] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0030] It should be noted that all the directional indications in the embodiments of the present application are only used to explain the relative positional relationship, movement conditions, etc. between components in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0031] In the present application, unless otherwise clearly specified and limited, the terms "connection", "fixation", etc. shall be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly limited. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0032] In addition, in the present application, the descriptions such as "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present application.

[0033] When the biomedical low-temperature freeze-drying device is in use, the article is placed on the tray inside the storage rack, and the low-temperature freeze-drying treatment of the article can be carried out.

[0034] In the related art, by setting a moving tray, a support rod, a slider, a screw rod, an anti-slip pad and a fastening nut, turning the fastening nut to cooperate with the thread on the screw rod, the fastening nut can move left and right on the screw rod, and then drive the anti-slip pad to move left and right. When the fastening nut squeezes the anti-slip pad to be in close contact with the support rod, the position of the moving tray can be restricted. On the contrary, the operator can move the moving tray up and down to a suitable position and then carry out the limit. Then, for the storage rack of the low-temperature freeze-drying device, the distance between the trays can be adjusted accordingly according to the size of the actual experimental article, so as to expand the range of the experimental article and improve the applicability of the freeze-drying device. However, in actual use, the distances between multiple trays need to be adjusted and fixed in sequence, resulting in low adjustment efficiency and inconvenience for the staff to use.

[0035] In order to solve the problems in the related art to a certain extent, the embodiments of the present application provide a low-temperature freeze-drying device and a usage method for biological medicine. When in use, after rotating the mounting plate 21 outwards, separating the mounting plate 21 from the plurality of trays 14, manually pushing the plurality of trays 14, and slowly rotating the mounting plate 21 inwards, after the rubber pad 22 abuts against the plurality of trays 14 in sequence, the simultaneous height adjustment of the plurality of trays 14 is completed, which is more convenient and fast, and improves the convenience of the device.

[0036] The present application will be described below with reference to the accompanying drawings and specific embodiments:

[0037] Combined with Figures 1 - 5 , the embodiments of the present application provide a low-temperature freeze-drying device and a usage method for biological medicine, including: a freeze dryer 10, a placement rack 11 is arranged on the top thereof, a sealing cover 12 is installed on the top of the freeze dryer 10, a pipe body 13 is arranged on the side of the freeze dryer 10, the pipe body 13 is respectively an air extraction pipe and an exhaust pipe, and a mechanical valve is arranged, a tray 14 is slidably connected to the placement rack 11, a groove 20 is formed on the placement rack 11, a mounting plate 21 is rotatably connected in the groove 20, a rubber pad 22 is fixedly connected to one side of the mounting plate 21, the rubber pad 22 is in close contact with the tray 14 and is in the shape of a right trapezoid, a groove 23 is formed on the placement rack 11, the top end of the rubber pad 22 is inserted into the groove 23, a set screw 24 is threadedly connected to the placement rack 11, a hole 25 is formed on the mounting plate 21, and one end of the set screw 24 is inserted into the hole 25.

[0038] After placing the freeze dryer 10 at the designated position, rotate the mounting plate 21 outwards, causing the mounting plate 21 to drive the rubber pad 22 to rotate outwards within the first groove body 20, separating the rubber pad 22 from the multiple trays 14 simultaneously. Then, cancel the height limit of the multiple trays 14. Subsequently, push the lowermost tray 14 and slowly rotate the mounting plate 21 inwards at the same time until the lowermost tray 14 is pushed to the appropriate height. Then, push the mounting plate 21 to make the rubber pad 22 contact the lowermost tray 14, which limits the height of the lowermost tray 14. At this time, push the second-lowermost tray 14 from the bottom upwards and continue to rotate the mounting plate 21. Repeat the above steps to simultaneously adjust and limit the heights of the multiple trays 14 to complete the adjustment. When limiting the second tray 14, the previously limited trays 14 squeeze the rubber pad 22, causing the rubber pad 22 to deform. Without affecting the normal rotation of the mounting plate 21, the limiting effect on the tray 14 is improved by increasing the friction force. Finally, rotate the first set screw 24 so that one end of the first set screw 24 inserts into the hole body 25 to fix the angle of the mounting plate 21 to complete the adjustment. Finally, place the items to be processed on the trays 14, put the sealing cover 12 on the top of the freeze dryer 10, and cover the placement rack 11 to complete the placement. Then, connect the power supply of the freeze dryer 10 and turn on the freeze dryer 10 to make the freeze dryer 10 enter the refrigeration state. The model of the freeze dryer 10 is LC-10N-80A, which belongs to the prior art, and its refrigeration and low-temperature freeze-drying operations belong to the prior art, so no more details will be described here. Finally, after docking the pipe body 13 for air extraction with the vacuum pump, perform the low-temperature freeze-drying operation. After the processing is completed, close the valve on the air extraction pipe body 13, turn off the vacuum pump, and take out the items.

[0039] In some embodiments, the rubber pad 22 is a silicone rubber pad, enabling the rubber pad 22 to still be used normally in a low-temperature environment.

[0040] In some embodiments, the length of the second groove body 23 is greater than the length of the first groove body 20. Rotate the mounting plate 21 outwards so that the mounting plate 21 forms an obtuse angle with the horizontal line, and then rotate the mounting plate 21 inwards so that the mounting plate 21 forms an acute angle with the horizontal line, while enabling the right-angled trapezoidal rubber pad 22 to simultaneously press tightly against the multiple trays 14.

[0041] In some embodiments, a third groove body 30 is provided on the placement rack 11. A plate body 31 is slidably connected within the third groove body 30. A tooth 32 is fixedly connected to the side of the plate body 31. A slot 33 is provided on the outside of the tray 14. The tooth 32 is inserted into the slot 33, and a second set screw 34 is threadedly connected to the placement rack 11.

[0042] When it is necessary to lock the height of the tray 14, rotate the setscrew two 34. While the setscrew two 34 pushes the plate body 31 to slide in the groove body three 30, drive the locking teeth 32 to slide until the locking teeth 32 are inserted into the card slot 33 outside the corresponding tray 14, and the outside locks the height of the tray 14.

[0043] In some embodiments, a plurality of the setscrews two 34 are provided. The plurality of setscrews two 34 can be used simultaneously or separately, improving the practicability.

[0044] In some embodiments, a limiting plate 40 is slidably connected to the placement rack 11. One end of the limiting plate 40 is located directly below the setscrew one 24, and the other end is in close contact with the plate body 31.

[0045] When adjusting the height of the tray 14, push the limiting plate 40. While the limiting plate 40 slides on the placement rack 11 and one end of it abuts against the plate body 31, rotate the setscrew one 24. After the bottom end of the setscrew one 24 abuts against one side of the limiting plate 40, it plays a role in limiting the left and right positions of the limiting plate 40 (the direction is for reference Figure 5 ), so that the limiting plate 40 plays a role in limiting the plate body 31, preventing the position of the plate body 31 from shifting during the adjustment process and affecting the normal adjustment of the height of the tray 14. On the contrary, after the adjustment is completed, when the mounting plate 21 is inserted into the groove body two 23, the limiting plate 40 penetrates the mounting plate 21, enabling the mounting plate 21 to slide left and right normally. Finally, one end of the setscrew one 24 is inserted into the mounting plate 21 to fix the angle of the mounting plate 21. At this time, when the setscrew two 34 is rotated, the plate body 31 pushes the limiting plate 40 to slide out of the mounting plate 21, without affecting the normal use of the plate body 31.

[0046] Specifically, a through groove having the same size as one end of the limiting plate 40 is formed in the mounting plate 21. After the limiting plate 40 passes through the through groove, it penetrates the mounting plate 21.

[0047] In some embodiments, the limiting plate 40 is C-shaped, preventing the limiting plate 40 from separating from the placement rack 11.

[0048] In some embodiments, the distance between the groove body one 20 and the groove body three 30 is greater than the diameter of the tray 14, preventing the mounting plate 21 and the plate body 31 from affecting the height adjustment of the tray 14.

[0049] In the description of this specification, the descriptions referring to terms such as "one embodiment", "some embodiments", "example", "specific example", "some examples", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine the different embodiments or examples described in this specification.

[0050] In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0051] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biomedical low-temperature freeze-drying device, characterized in that: include: A freeze dryer (10) is provided with a placement rack (11) on the top, a sealing cover (12) is installed on the top of the freeze dryer (10), a pipe body (13) is provided on the side of the freeze dryer (10), the pipe body (13) is respectively an exhaust pipe and an exhaust pipe, and is provided with a mechanical valve, a tray (14) is slidably connected to the placement rack (11), a groove body (20) is opened on the placement rack (11), and a mounting plate (21) is rotatably connected in the groove body (20), A rubber pad (22) is fixedly connected to one side of the mounting plate (21), the rubber pad (22) is tightly attached to the tray (14) and is in a right-angled trapezoidal shape, a second groove body (23) is provided on the placement frame (11), the top end of the rubber pad (22) is inserted into the second groove body (23), a fixing bolt (24) is threadedly connected to the placement frame (11), a hole body (25) is provided on the mounting plate (21), one end of the fixing bolt (24) is inserted into the hole body (25).

2. A biopharmaceutical low-temperature freeze-drying device according to claim 1, characterized in that: The rubber pad (22) is a silicone rubber pad.

3. A biopharmaceutical low-temperature freeze-drying device according to claim 1, characterized in that: The length of the second trough body (23) is greater than the length of the first trough body (20).

4. A biopharmaceutical low-temperature freeze-drying device according to claim 1, characterized in that: The placement rack (11) is provided with a third groove body (30), a plate body (31) is slidably connected inside the third groove body (30), a latching tooth (32) is fixedly connected to the side of the plate body (31), a latching groove (33) is provided on the outer side of the tray (14), the latching tooth (32) is inserted into the latching groove (33), and a fixing bolt (34) is threadedly connected to the placement rack (11).

5. A biopharmaceutical low-temperature freeze-drying device according to claim 4, characterized in that: The second fixing bolt (34) is provided in plurality.

6. A biopharmaceutical low-temperature freeze-drying device according to claim 4, characterized in that: A limiting plate (40) is slidably connected to the placement frame (11), one end of the limiting plate (40) is located directly below the fixing bolt (24), and the other end is tightly attached to the plate body (31).

7. A biopharmaceutical low-temperature freeze-drying device according to claim 6, characterized in that: The limiting plate (40) is in a C-shape.

8. A biopharmaceutical low-temperature freeze-drying device according to claim 6, characterized in that: The distance between the trough body one (20) and the trough body three (30) is greater than the diameter of the tray (14).

9. A biopharmaceutical low-temperature freeze-drying method, according to a biopharmaceutical low-temperature freeze-drying device according to any one of claims 1 to 8, characterized in that: The following steps are involved: S1: After placing the freeze dryer 10 at a designated location, the mounting plate (21) is rotated outwardly, so that the mounting plate (21) drives the rubber pad (22) to rotate outwardly in the tank body (20), until the rubber pad (22) is separated from the plurality of trays (14) at the same time, and the height limit of the plurality of trays (14) is cancelled; S2: Then, the bottom tray (14) is pushed, and the mounting plate (21) is slowly rotated inwards at the same time, until the bottom tray (14) is pushed to a suitable height, and then the mounting plate (21) is pushed to make the rubber pad (22) contact with the bottom tray (14), so as to limit the height of the bottom tray (14); S3: At this time, the second to last tray (14) at the bottom is pushed upward, and the mounting plate (21) is continued to be rotated, and the above steps are repeated to achieve simultaneous adjustment and limit of the heights of multiple trays (14), and the adjustment is completed; S4: When limiting the position of the second tray (14), the previously limited tray (14) squeezes the rubber pad (22), causing the rubber pad (22) to deform, without affecting the normal rotation of the mounting plate (21). At the same time, the limiting effect of the tray (14) is improved by increasing the friction force; S5: Finally, the fixing bolt 1 (24) is rotated to insert one end of the fixing bolt 1 (24) into the hole (25), thereby fixing the angle of the mounting plate (21) and completing the adjustment; S6: The articles to be processed are then placed on the tray (14), and the sealing cover (12) is placed on the top of the freeze dryer (10) to cover the placement rack (11), and the placement is completed; S7: Connect the power supply of the freeze dryer (10) and start the freeze dryer (10) to put the freeze dryer (10) into a refrigeration state. After the tube body (13) for exhausting air is connected to the vacuum pump, the low-temperature freeze-drying operation can be performed. After the processing is completed, the valve on the exhaust tube body (13) is closed, the vacuum pump is turned off, and the items can be taken out.

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