Light aging experiment device for mice

Abstract

The invention relates to the technical field of light aging experiments, and mainly discloses a light aging experiment device for mice, which is characterized by comprising a shell; the adjusting assembly comprises a clamping plate, adjusting plates and a partition plate, the adjusting plates are symmetrically fixed to the bottom of the clamping plate and movably arranged in the shell, the two ends of the partition plate are fixed to the adjusting plates, and the two ends of the light source are connected with the adjusting plates; the mouse isolation device solves the problem that an existing device cannot achieve illumination uniformity while isolating mice of different body types.

Description

Technical Field

[0001] The invention relates to the technical field of photoaging experiments, in particular to a photoaging experiment device for mice. Background Art

[0002] The photoaging experiment of mice is to irradiate mice with ultraviolet rays through a specific device to simulate the damage process of light to the skin in the natural environment. The experiment observes the histological and physiological changes of mouse skin under the action of ultraviolet rays, such as collagen fiber degradation and abnormal proliferation of elastic fibers, etc. It is used to study the mechanism of skin photoaging, evaluate the effects of sunscreen products and anti-aging drugs, and provide theoretical basis and experimental foundation for the prevention and treatment of skin aging.

[0003] In the experimental study of photoaging in mice, existing technologies face many challenges. In experimental scenarios where mice need to be isolated, the isolation space of traditional experimental devices is often fixed and unchanged, which is difficult to meet the experimental needs of mice of different numbers and sizes. It not only limits the scale of the experiment, but also may affect the welfare of the mice. At the same time, the unreasonable design of the lighting system leads to uneven distribution of light intensity in the box, and there are large differences in the ultraviolet doses received by mice in different positions, which seriously affects the accuracy and reliability of the experimental results. When the mice are not isolated and the light aging experiment is simulated in the natural environment, the external environmental variables are complex and changeable, and the lighting conditions are difficult to control accurately, causing the experimental results to be interfered by a variety of uncontrollable factors, and the repeatability and stability are poor. Therefore, there is an urgent need for a mouse photoaging experimental device that can flexibly adjust the size of the isolation space, effectively solve the problem of uneven lighting, and accurately control the lighting parameters, so as to improve the quality and efficiency of the experiment and promote the development of related research. Summary of the invention

[0004] Therefore, the technical problem to be solved by the present invention is that the existing device cannot meet the requirements of isolating mice of different sizes while taking into account the uniformity of lighting.

[0005] The above technical problem is solved by the following technical solution: The present invention proposes a photoaging experimental device for mice, which includes a shell; an adjustment component, including a clamping plate, an adjustment plate and a partition, the adjustment plate is symmetrically fixed to the bottom of the clamping plate and movably arranged in the shell, and the two ends of the partition are fixed to the adjustment plate; and a light source, whose two ends are connected to the adjustment plate.

[0006] In a preferred embodiment of the photoaging experimental device for mice of the present invention: a locking piece is fixedly connected to the top of the shell, and the locking piece includes a plug-in strip and tooth plates symmetrically fixed on both sides thereof; the bottom end of the plug-in strip is fixedly connected to the shell through a connecting ear, and a first spring is fixedly connected to the top of the connecting ear; the plug-in strip is provided with inner elastic grooves on the side walls on both sides near the connecting ears, the tooth plates can be fitted and placed in the inner elastic grooves, and a second spring is connected between the tooth plates and the inner wall of the inner elastic grooves.

[0007] In a preferred embodiment of the light aging experimental device for mice of the present invention: a support plate is fixedly connected inside the shell, the bottom of the shell is open, and a ventilation mesh plate is sealed and connected to the opening.

[0008] In a preferred embodiment of the photoaging experimental device for mice of the present invention: a through hole is opened in the middle of the clamping plate, and docking tooth blocks are symmetrically fixedly connected to the inner walls on both sides opposite to the through hole, and the docking tooth blocks are movably clamped with the tooth plate, and the top of the first spring is fixedly connected to the clamping plate.

[0009] In a preferred embodiment of the photoaging experimental device for mice of the present invention: the adjustment plate includes a control plate and a floating card strip, the top of the control plate is fixedly connected to the card plate via a connecting strip, and the bottom of the control plate is symmetrically fixedly connected with a hinge plate; a plurality of groups of adjustment sliding holes are symmetrically opened on the control plate, and the distance between the top ends of the plurality of groups of adjustment sliding holes is smaller than the distance between the bottom ends.

[0010] In a preferred embodiment of the photoaging experimental device for mice of the present invention: the number of the floating card strips corresponds to the number of the adjusting sliding holes, the two ends of the floating card strip are fixedly connected with a snap-in slider, and the snap-in slider is slidably snap-in with a sliding strip connected to the inner wall of the shell; the two ends of the light source are fixedly connected to the snap-in slider through a sliding rod, and the sliding rod is slidably inserted into the adjusting sliding hole; the middle part of the floating card strip is fixedly connected with a mounting block, and the side wall of the mounting block is provided with a slot.

[0011] In a preferred embodiment of the photoaging experimental device for mice of the present invention: an auxiliary push piece is rotatably connected between the hinge plates connected to the adjustment plates on both sides, and the auxiliary push piece includes a first plug rod and a second plug rod, and the first plug rod and the second plug rod are fixedly connected by a connecting plate.

[0012] In a preferred embodiment of the photoaging experimental device for mice of the present invention: the first plug rod is rotatably inserted into the hinge plate, the second plug rod is also rotatably connected to a retractable plate, and the bottom end of the retractable plate is slidably inserted into the support plate.

[0013] In a preferred embodiment of the photoaging experimental device for mice of the present invention: the partition includes a first plate and a second plate, the top of the first plate is provided with a groove, a contraction groove and a stable groove connecting the two, a card block is slidably inserted in the stable groove, the card block is slidably inserted into the card slot, and a third spring is fixedly connected between the card block and the wall of the contraction groove; the second plate is slidably inserted into the stable groove, and a built-in bar is also fixedly connected at the bottom thereof, the built-in bar is slidably inserted into the groove, and a fourth spring is fixedly connected between the built-in bar and the bottom of the groove; an auxiliary groove is provided on the top of the card block, and the second plate is slidably inserted into the auxiliary groove.

[0014] In a preferred embodiment of the photoaging experimental device for mice of the present invention: a placement hole is provided on the side wall of the housing close to the adjustment plate, and an installation chute is further provided on the outer wall of the housing at the top of the placement hole. A cover is slidably clamped in the installation chute on this side, and the cover can cooperate to seal the placement hole; a placement space is formed between the partition plates, and the volume of the placement space is variable.

[0015] The beneficial effects of the present invention are as follows:

[0016] By sliding the adjustment plate up and down, the device can simultaneously control the lateral movement of multiple groups of partition plates. During this process, the light source moves synchronously with the partition plates, and the light can completely cover the placement space for storing mice, improving the light uniformity; and the partition plates are made of transparent materials to avoid light dead corners; the partition plates can be detachably mounted on the adjustment plate, and for mice of different body sizes, the partition plates can be flexibly disassembled and assembled to increase or decrease the space, avoiding too small an activity range for the mice. Description of the Drawings

[0017] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings of the embodiments of the present invention will be briefly introduced below. Obviously, the drawings in the following description only relate to some embodiments of the present invention and do not limit the present invention. Among them:

[0018] Figure 1 Shows a cross-sectional view of the photoaging experimental device for mice;

[0019] Figure 2 Shows a half cross-sectional view of the housing of the photoaging experimental device for mice;

[0020] Figure 3 Shows an installation diagram of the cover of the photoaging experimental device for mice;

[0021] Figure 4 Shows a structural diagram of the clamping plate of the photoaging experimental device for mice;

[0022] Figure 5 Shows a structural diagram of the adjustment plate of the photoaging experimental device for mice;

[0023] Figure 6 Shows a structural diagram of the partition plate of the photoaging experimental device for mice;

[0024] Figure 7 Shows a diagram of the volume change of the placement space of the photoaging experimental device for mice. Detailed Embodiments

[0025] To enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below in conjunction with specific embodiments and the accompanying drawings.

[0026] The terms used in the present invention are those general terms that are currently widely used in the art in consideration of the functions of the present invention. However, these terms may vary according to the intentions of those of ordinary skill in the art, precedents, or new technologies in the art. In addition, specific terms may be selected by the applicant, and in such cases, their detailed meanings will be described in the detailed description of the present invention. Therefore, the terms used in the specification should not be understood as simple names, but based on the meanings of the terms and the overall description of the present invention.

[0027] Example 1

[0028] Referring to Figures 1 to 7 , as the first embodiment of the present invention, a photoaging experimental device for mice is provided, which includes a housing 100. The housing 100 is a rectangular metal housing with an accommodation space inside for storing experimental mice. Four corners of the bottom of the housing 100 are fixed with support feet to maintain the overall stability of the device.

[0029] The adjustment assembly 200 includes a clamping plate 201, an adjustment plate 202, and a partition plate 203. The adjustment plate 202 is symmetrically fixed to the bottom of the clamping plate 201 and is movably arranged inside the housing 100. Both ends of the partition plate 203 are fixed to the adjustment plate 202.

[0030] Among them, the clamping plate 201 is a rectangular metal plate, preferably made of aluminum alloy, with a light weight. The adjustment plate 202 is slidably inserted into the housing 100 and can slide up and down to control the horizontal movement of the partition plate 203.

[0031] The light source 300, whose two ends are connected to the adjustment plate 202. The light source 300 preferably adopts a UVA / UVB light source to simulate the real ultraviolet irradiation situation. By setting the irradiation dose or time, the photoaging irradiation test on mice can be automatically completed.

[0032] Specifically, a locking member 101 is fixedly connected to the top of the housing 100. The locking member 101 includes a plugging strip 101a and tooth plates 101b symmetrically fixed on both sides thereof.

[0033] The bottom end of the plugging strip 101a is fixedly connected to the housing 100 through a connecting ear 101a-1. The connecting ear 101a-1 is fixed to the housing 100 by bolts. A first spring T1 is fixedly connected to the top of the connecting ear 101a-1. A total of two groups of first springs T1 are arranged on the two connecting ears 101a-1 on both sides.

[0034] The plug bar 101a is provided with inner elastic grooves 101a-2 on both side walls near the connecting ear 101a-1. The inner elastic grooves 101a-2 are rectangular grooves. The toothed plate 101b can be placed in the inner elastic grooves 101a-2 in a matching manner, and a second spring T2 is connected between the toothed plate 101b and the inner wall of the inner elastic groove 101a-2. Under the elastic force of the second spring T2, the tooth surface of the toothed plate 101b is pushed out of the notch of the inner elastic groove 101a-2.

[0035] A support plate 102 is fixedly connected inside the housing 100. The experimental mice are placed on the support plate 102. The support plate 102 is evenly provided with ventilation holes. The bottom of the housing 100 is open, and a ventilation net plate 103 is hermetically connected to the opening. Through the ventilation holes and the ventilation net plate 103, the cleanliness of the experimental environment of the mice can be maintained. The ventilation net plate 103 is used to receive food residues, feces and other dirt dropped by the mice above during use.

[0036] A placement hole K is provided on the side wall of the housing 100 close to the adjustment plate 202. A ventilation fan can also be installed on the opposite side. The experimenter can put the mice into the support plate 102 from the placement hole K. An installation chute K2 is also provided on the outer wall of the housing 100 at the top of the placement hole K. A cover 105 is slidably clamped in the installation chute K2 on this side. The cover 105 can cooperate to seal the placement hole K. During use, the cover 105 is inserted into the installation chute K2 from above and continues to move downward, and the placement hole K can be completely blocked to prevent the mice from escaping from the housing 100 during use.

[0037] A placement space K3 is formed between the partition plates 203. The volume of the placement space K3 is variable to adapt to mice of different body sizes.

[0038] Embodiment 2

[0039] Refer to Figures 1 to 7 , which is the second embodiment of the present invention. The difference between this embodiment and the first embodiment is that a through hole 201a is provided in the middle of the clamping plate 201. The through hole 201a is a rectangular hole, and its aperture is the same as the size of the plug bar 101a. Opposite inner walls of the through hole 201a are symmetrically and fixedly connected with docking tooth blocks 201a-1. The positions of the docking tooth blocks 201a-1 correspond to those of the toothed plate 101b. The docking tooth blocks 201a-1 are movably clamped with the toothed plate 101b. Among them, the teeth on the docking tooth blocks 201a-1 point obliquely upward, and the tooth grooves provided on the toothed plate 101b face obliquely downward. The top end of the first spring T1 is fixedly connected with the clamping plate 201.

[0040] During use, when the first spring T1 is in a natural straight state, the clamping plate 201 is lifted upward. At this time, the docking tooth blocks 201a-1 are clamped with the tooth grooves at the top of the toothed plate 101b.

[0041] Further, when the staff presses down the clamping plate 201, the teeth on the docking tooth block 201a-1 disengage from the tooth grooves formed on the tooth plate 101b, and the tooth plate 101b is pushed to move towards the inner wall of the elastic groove 101a-2, and the second spring T2 is compressed. At this time, the clamping plate 201 moves downward. When it reaches the appropriate height and the hand is released, the first spring T1 applies an upward thrust to the clamping plate 201. At the same time, the second spring T2 rebounds and pushes the tooth plate 101b outwards. The teeth on the docking tooth block 201a-1 are reinserted obliquely into the tooth grooves formed on the tooth plate 101b, and the height of the clamping plate 201 is fixed.

[0042] When the experimenter wants to restore the clamping plate 201 to its initial height, they only need to pinch the tops of the two side tooth plates 101b and manually operate the tooth plates 101b to contract, releasing the clamping between the docking tooth block 201a-1 and the tooth plate 101b. Combining with the upward thrust of the first spring T1, the clamping plate 201 will be driven to reset upward.

[0043] The adjusting plate 202 includes a control plate 202a and floating clamping strips 202b. The top of the control plate 202a is fixedly connected to the clamping plate 201 through a connecting strip 202a-1. Symmetrically fixed to the bottom of the control plate 202a are hinge plates 202a-2, and the control plate 202a will move up and down with the clamping plate 201.

[0044] A number of groups of adjusting sliding holes 202a-3 are symmetrically formed on the control plate 202a, and the distance between the tops of the several groups of adjusting sliding holes 202a-3 is smaller than the distance between the bottoms.

[0045] Specifically, referring to Figure 5 the top of the adjusting sliding hole 202a-3 is in a contracted state as a whole, and the bottom of the adjusting sliding hole 202a-3 is in a divergent state.

[0046] The number of floating clamping strips 202b corresponds to the number of adjusting sliding holes 202a-3. Both ends of the floating clamping strips 202b are fixedly connected with clamping sliders 202b-1, and the clamping sliders 202b-1 are slidably clamped with the sliding strips 104 connected to the inner wall of the housing 100. Specifically, under the restriction of the sliding strips 104, the floating clamping strips 202b can only slide horizontally and cannot move up and down.

[0047] Both ends of the light source 300 are fixedly connected to the clamping sliders 202b-1 through sliding rods 301, and the sliding rods 301 are slidably inserted into the adjusting sliding holes 202a-3.

[0048] The middle of the floating clamping strip 202b is fixedly connected with a mounting block 202b-2, and a clamping groove 202b-2a is formed on the side wall of the mounting block 202b-2.

[0049] During use, when the clamping plate 201 is at the highest position, the sliding rod 301 is at the bottom position of the adjusting sliding hole 202a-3. At this time, the distance between several groups of light sources 300 and the floating clamping strip 202b is the largest, that is, the volume of the placement space K3 is the largest at this time.

[0050] Furthermore, when the clamping plate 201 is pressed down, the sliding rod 301 contracts along the adjusting sliding hole 202a-3, driving the distance between the light source 300 and the floating clamping strip 202b to decrease. At this time, the volume of the placement space K3 is the smallest.

[0051] The remaining structures are the same as those in Embodiment 1.

[0052] Embodiment 3

[0053] Refer to Figures 1 to 7 , which is the third embodiment of the present invention. The difference between this embodiment and the second embodiment is that there is a secondary pusher 202c rotatably connected between the hinge plates 202a-2 connected to the two side adjusting plates 202. The secondary pusher 202c includes a first insertion rod 202c-1 and a second insertion rod 202c-2, and the first insertion rod 202c-1 and the second insertion rod 202c-2 are fixedly connected by a connecting plate 202c-3.

[0054] The first insertion rod 202c-1 is rotatably inserted into the hinge plate 202a-2, and a retractable plate 202d is also rotatably connected to the second insertion rod 202c-2. The bottom end of the retractable plate 202d is slidably inserted into the support plate 102.

[0055] During use, as the control plate 202a moves up and down, the hinge plate 202a-2 will push the secondary pusher 202c to slide horizontally on the support plate 102.

[0056] The partition 203 includes a first plate 203a and a second plate 203b. A groove 203a-1, a retraction groove 203a-2, and a stable groove 203a-3 connecting the two are formed at the top of the first plate 203a. A clamping block 203a-3a is slidably inserted into the stable groove 203a-3. The clamping block 203a-3a is slidably inserted into the card slot 202b-2a, and a third spring T3 is fixedly connected between the clamping block 203a-3a and the wall of the retraction groove 203a-2.

[0057] During use, if the volume of the placement space K3 adjusted by the control plate 202a still cannot meet the activity range of the mice, it is necessary to disassemble and adjust the partition 203. The partition 203 is fixed by the clamping block 203a-3a and the card slot 202b-2a. At this time, the partition 203 is vertically fixed as a whole. When it is necessary to remove the redundant partition 203, the experimenter toggles the clamping block 203a-3a, and the third spring T3 contracts and disengages from the card slot 202b-2a, and then the partition 203 can be removed.

[0058] The second plate 203b is slidably inserted into the stable groove 203a-3, and a built-in strip 203b-1 is fixedly connected to its bottom. The built-in strip 203b-1 is slidably inserted into the groove 203a-1, and a fourth spring T4 is fixedly connected between the built-in strip 203b-1 and the bottom of the groove 203a-1.

[0059] An auxiliary groove 203c-1a is formed at the top of the clamping block 203a-3a. The second plate 203b is slidably inserted into the auxiliary groove 203c-1a. During use, the fourth spring T4 can lift the second plate 203b to prevent larger mice from coming into contact with the mice in the adjacent compartment and eliminate conflicts between the mice.

[0060] Furthermore, under experimental conditions where it is not necessary to isolate the mice, the partition 203 can be completely removed. At this time, the auxiliary pusher 202c can be controlled to adjust the activity range of the mice; and the flexible adjustment of the position of the light source 300 can achieve the switching between concentrated irradiation and divergent irradiation of the light source 300, without having to completely rely on adjusting the light intensity of a single light source 300.

[0061] The remaining structure is the same as that of Embodiment 2.

[0062] Finally, it should be pointed out that the methods and devices described in detail above are only examples, and those skilled in the art can modify these examples in different ways as long as they do not depart from the scope of the present invention.

Claims

1. A photoaging experimental device for mice, characterized in that: include, Housing (100); An adjustment component (200) comprises a clamping plate (201), an adjustment plate (202) and a partition plate (203), wherein the adjustment plate (202) is symmetrically fixed to the bottom of the clamping plate (201) and movably arranged in the housing (100), and both ends of the partition plate (203) are fixed to the adjustment plate (202); and; The light source (300) has two ends connected to the adjustment plate (202).

2. The photoaging experimental device for mice according to claim 1, characterized in that: A locking member (101) is fixedly connected to the top of the housing (100), and the locking member (101) comprises a plug-in strip (101a) and tooth plates (101b) symmetrically fixed on both sides thereof; The bottom end of the plug strip (101a) is fixedly connected to the housing (100) via a connecting ear (101a-1), and the top of the connecting ear (101a-1) is fixedly connected to a first spring (T1); The plug strip (101a) is provided with inner elastic grooves (101a-2) on the side walls close to the connecting ears (101a-1), the tooth plate (101b) can be placed in the inner elastic groove (101a-2), and a second spring (T2) is connected between the tooth plate (101b) and the inner wall of the inner elastic groove (101a-2).

3. The photoaging experimental device for mice according to claim 2, characterized in that: A support plate (102) is fixedly connected inside the shell (100); the bottom of the shell (100) is open, and a ventilation mesh plate (103) is sealedly connected to the opening.

4. The photoaging experimental device for mice according to claim 2 or 3, characterized in that: A through hole (201a) is provided in the middle of the clamping plate (201), and opposite inner walls of the through hole (201a) are symmetrically fixedly connected with docking tooth blocks (201a-1), the docking tooth blocks (201a-1) are movably clamped with the tooth plate (101b), and the top end of the first spring (T1) is fixedly connected to the clamping plate (201).

5. The photoaging experimental device for mice according to claim 4, characterized in that: The adjustment plate (202) comprises a control plate (202a) and a floating clamping strip (202b); the top of the control plate (202a) is fixedly connected to the clamping plate (201) via a connecting strip (202a-1); and the bottom of the control plate (202a) is symmetrically fixedly connected to a hinge plate (202a-2); The control plate (202a) is symmetrically provided with a plurality of groups of adjusting sliding holes (202a-3), and the distance between the top ends of the plurality of groups of adjusting sliding holes (202a-3) is smaller than the distance between the bottom ends.

6. The photoaging experimental device for mice according to claim 5, characterized in that: The number of the floating clamping strips (202b) corresponds to the number of the adjusting sliding holes (202a-3); both ends of the floating clamping strips (202b) are fixedly connected with clamping sliders (202b-1); the clamping sliders (202b-1) are slidably clamped with the sliding strips (104) connected to the inner wall of the housing (100); Two ends of the light source (300) are fixedly connected to the clamping slider (202b-1) via a sliding rod (301), and the sliding rod (301) is slidably inserted into the adjusting sliding hole (202a-3); A mounting block (202b-2) is fixedly connected to the middle of the floating clamping strip (202b), and a clamping groove (202b-2a) is provided on a side wall of the mounting block (202b-2).

7. The photoaging experimental device for mice according to claim 5 or 6, characterized in that: An auxiliary push member (202c) is rotatably connected between the hinge plates (202a-2) connected to the adjustment plates (202) on both sides, and the auxiliary push member (202c) comprises a first insertion rod (202c-1) and a second insertion rod (202c-2), and the first insertion rod (202c-1) and the second insertion rod (202c-2) are fixedly connected via a connecting plate (202c-3).

8. The photoaging experimental device for mice according to claim 7, characterized in that: The first insertion rod (202c-1) is rotatably inserted into the hinge plate (202a-2), and the second insertion rod (202c-2) is also rotatably connected to a retractable plate (202d), and the bottom end of the retractable plate (202d) is slidably inserted into the support plate (102).

9. The photoaging experimental device for mice according to claim 6, characterized in that: The partition (203) comprises a first plate (203a) and a second plate (203b); the top of the first plate (203a) is provided with a groove (203a-1), a contraction groove (203a-2) and a stable groove (203a-3) connecting the two; a card block (203a-3a) is slidably inserted in the stable groove (203a-3); the card block (203a-3a) is slidably inserted in the card groove (202b-2a); a third spring (T3) is fixedly connected between the card block (203a-3a) and the groove wall of the contraction groove (203a-2); The second plate (203b) is slidably inserted into the stabilizing groove (203a-3), and a built-in bar (203b-1) is fixedly connected to the bottom of the second plate (203b), and the built-in bar (203b-1) is slidably inserted into the groove (203a-1), and a fourth spring (T4) is fixedly connected between the built-in bar (203b-1) and the bottom of the groove (203a-1); An auxiliary groove (203c-1a) is provided on the top of the block (203a-3a), and the second plate (203b) is slidably inserted into the auxiliary groove (203c-1a).

10. The photoaging experimental device for mice according to any one of claims 1 to 3, 5, 6, 8 and 9, characterized in that: A placement hole (K) is provided on the side wall of the shell (100) close to the adjustment plate (202), and a mounting groove (K2) is also provided on the outer wall of the shell (100) at the top of the placement hole (K). A cover (105) is slidably engaged in the mounting groove (K2) on this side, and the cover (105) can cooperate with the sealing placement hole (K); A placement space (K3) is formed between the partitions (203), and the volume of the placement space (K3) is variable.

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