Light-blocking intravenous feeding bag and method of manufacturing the same

Abstract

The present application relates to a light-proof barrier type intravenous nutrition bag and a manufacturing method thereof. The light-proof barrier type intravenous nutrition bag comprises a bag body, a liquid inlet end and a liquid outlet end arranged at the lower end of the bag body, and the bag body is made of a light-proof barrier type film layer; the liquid inlet end comprises a sealing end, a liquid inlet pipeline, and two passages connecting the liquid inlet pipeline and the sealing end, and the sealing end is arranged between the bag body and the two passages; the light-proof barrier type film layer comprises an inner layer, a secondary inner layer, a secondary outer layer, and an outer layer from inside to outside, the secondary inner layer is an inner adhesive layer, and the secondary outer layer comprises a barrier layer close to the secondary inner layer and a light-proof adhesive layer close to the outer layer; wherein the material of the inner layer is EVA, the material of the inner adhesive layer is EVA, the material of the barrier layer is EVOH, and the material of the light-proof adhesive layer is composed of EVA and PP. The bag body has a simple structure, simplifies the components on the liquid inlet pipeline, greatly reduces the material cost and assembly cost of the product, and has multiple and stable and reliable heat sealing options; the bag body material does not need to add additives to realize the light-proof function, and the nutrition bag has good safety performance.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical devices, and particularly relates to a light-blocking type intravenous nutrition bag and a manufacturing method thereof. BACKGROUND

[0002] At present, the intravenous nutrition infusion bags on the market are all completed in the hospital's compounding center, then transported to the patient's room for infusion, and the infusion needs to be completed within 24 hours after the nutrition solution is prepared. When the intravenous nutrition infusion is applied at home, batch preparation needs to be completed in a professional medical institution, and the patient stores the nutrition solution of a certain period of use at home for storage and reinfusion according to the doctor's advice. Generally, when applied in home nutrition, the intravenous nutrition solution needs to be stored in the bag body under low temperature and in the dark for more than 7 days.

[0003] The conventional intravenous nutrition infusion bag cannot meet the above long-term storage requirements, and has the following problems:

[0004] 1. The bag body on the market is a single-layer structure, generally welded by a film of ethylene-vinyl acetate copolymer (EVA) material, and the EVA film layer does not have light-blocking and barrier functions. Vitamins in the nutrition solution are relatively sensitive to light, and fat emulsion and amino acids are relatively sensitive to oxygen. The above components are prone to degradation during long-term storage, resulting in changes in the composition of the solution and a decrease in the effective components.

[0005] 2. The bag body on the market is a multi-layer structure. The commonly used barrier type multi-layer co-extrusion film needs to add a large amount of adhesive for bonding the barrier layer of ethylene-vinyl alcohol copolymer (EVOH) and other layers. The adhesive usually adopts maleic anhydride grafted polyethylene (PE-G-MAH), or a multi-layer co-extrusion film provided in Chinese patent CN105419058B, which uses maleic anhydride modified ethylene octene copolymer (POE-g-MAH) as the adhesive layer. However, whether modified or grafted, a large amount of initiators, antioxidants, and branch agents are usually added during the preparation of the adhesive, which has great risks in medical packaging.

[0006] 3. At present, the structure of the intravenous nutrition infusion bag used in the clinic is as shown in Figure 1 The liquid inlet end structure connected with a plurality of liquid inlet pipelines is complex. After the liquid filling of the intravenous nutrition infusion bag is completed, the liquid inlet pipeline needs to be separated from the bag body through the detachable locking inner and outer cones on the bag body, which is relatively cumbersome to operate and has the risk of liquid leakage at the locking inner and outer cones. SUMMARY

[0007] The technical problem to be solved by the present application is: in view of the above defects, the present application provides a light-blocking type intravenous nutrition bag and a manufacturing method thereof, which solves the problems of complex structure of the liquid inlet pipeline of the existing intravenous nutrition bag, short storage time of the nutrient solution, and many additives in the multi-layer film structure, thereby causing the hidden danger of drug use.

[0008] The technical solution adopted by the present application to solve its technical problem is as follows: a light-blocking type intravenous nutrition bag, comprising a bag body, a liquid inlet end and a liquid outlet end are arranged at the lower end of the bag body, and the bag body is made of a light-blocking type film layer; the liquid inlet end comprises a sealing end communicated with the bag body, a liquid inlet pipeline communicated with a filling device, and a two-way connector connecting the liquid inlet pipeline and the sealing end, a pipeline locking member is arranged at the two-way connector, and the sealing end is arranged between the bag body and the two-way connector;

[0009] The light-blocking type film comprises an inner layer, a secondary inner layer, a secondary outer layer and an outer layer from inside to outside, the secondary inner layer is an inner adhesive layer, the secondary outer layer comprises a barrier layer close to the secondary inner layer and a light-blocking adhesive layer close to the outer layer; wherein the material of the inner layer is ethylene-vinyl acetate copolymer (EVA), the material of the inner adhesive layer is ethylene-vinyl acetate copolymer (EVA), the material of the barrier layer is ethylene-vinyl alcohol copolymer (EVOH), and the material of the light-blocking adhesive layer is ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP).

[0010] Further, the material of the outer layer is one or more of polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET) and polyamide (PA).

[0011] Further, the mass ratio of ethylene-vinyl acetate copolymer (EVA) to polypropylene (PP) in the material of the light-blocking adhesive layer is 1:(1.1-2.5).

[0012] Further, the total thickness of the light-blocking type film is 0.08mm-0.50mm; the thickness of the inner layer, the inner adhesive layer, the barrier layer, the light-blocking adhesive layer and the outer layer accounts for 20%-40%, 10%-25%, 6%-20%, 30%-50% and 25%-40% of the light-blocking respectively.

[0013] Further, the content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the inner layer is 12%-28%; the content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the inner adhesive layer is 18%-40%; and the content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the light-blocking adhesive layer is 18%-40%.

[0014] Further, the liquid outlet end comprises a liquid outlet pipeline and a liquid outlet socket, and the liquid outlet socket is arranged at the end of the liquid outlet pipeline.

[0015] The bag body is further provided with a bag hanging hole.

[0016] The manufacturing method of the light-proof and barrier type intravenous nutrition bag comprises the following steps:

[0017] In step S1, the raw materials of the light-proof and barrier type film are prepared: ethylene-vinyl acetate copolymer (EVA) for the inner layer, ethylene-vinyl acetate copolymer (EVA) for the inner adhesive layer, ethylene-vinyl alcohol copolymer (EVOH) for the barrier layer, a blend of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP) for the light-proof adhesive layer, and outer layer material for the outer layer are respectively placed on a preparation table;

[0018] In step S2, the light-proof and barrier type film is prepared: a vacuum suction machine sucks the raw materials on the preparation table into the hopper of a multi-hole extruder, and a light-proof and barrier type film is produced through co-extrusion film blowing or casting process, and the light-proof and barrier type film is irradiated after being extruded; the film layer structure is arranged in the order of an inner layer of ethylene-vinyl acetate copolymer (EVA), an inner adhesive layer of ethylene-vinyl acetate copolymer (EVA), a barrier layer of ethylene-vinyl alcohol copolymer (EVOH), a light-proof adhesive layer of a blend, and an outer layer of outer layer material;

[0019] In step S3, the nutrition bag is formed: the light-proof and barrier type film roll is unwound, gold-plated, heat-sealed, cooled, and cut into a special shape to obtain a formed nutrition bag.

[0020] In step S4, the air tightness of the nutrition bag is detected: sterile gas is blown into the bag body through the sealed end of the formed nutrition bag obtained in step S3.

[0021] Further, in step S2, the radiation dose of the irradiation is 5-15 Mard; in step S3, the gold plating temperature is 150-180℃, and the pressure is 0.2-0.4 Mpa; in step S4, the pressure of the sterile gas blown in is 4-6 pa.

[0022] Further, the ethylene-vinyl acetate copolymer, ethylene-vinyl alcohol copolymer, polypropylene, and outer layer material are respectively pretreated before use, and the pretreatment process is as follows: the materials to be pretreated are respectively added to an organic solvent, ultrasonic immersion is performed, after the organic solvent is removed, the pretreated materials are vacuum dried to complete the preliminary pretreatment; the materials after the preliminary pretreatment are soaked in water, ultrasonic oscillation is performed for 1-3 h, and then vacuum drying is performed after the water is removed.

[0023] Further, the organic solvent used in the pretreatment of the ethylene-vinyl acetate copolymer (EVA) is N,N-dimethylformamide (DMF); the organic solvent used in the pretreatment of the ethylene-vinyl alcohol copolymer (EVOH) is N,N-dimethylformamide (DMF); and the organic solvent used in the pretreatment of the polypropylene (PP) is a mixed solution of ethanol and acetone.

[0024] The beneficial effects of the present application are:

[0025] 1. The present application provides a light-blocking type intravenous nutrition bag, the bag body is made of a light-blocking type film, wherein the inner layer directly contacted with the liquid medicine is made of EVA material, which is a long-term clinical application of infusion material, ensuring the safety of the nutrition bag.

[0026] 2. The barrier layer is made of EVOH, which is easy to stretch and has good heat resistance, meeting the requirements of processing and producing a sterile packaging bag, and ensuring the safety of the nutrition bag.

[0027] 3. The secondary outer layer is a barrier layer and a light-blocking adhesive layer, wherein the light-blocking adhesive layer is made of safe and reliable EVA mixed with PP, the two materials are incompatible with each other, and exhibit a matte effect when film forming, the formed film layer has a transmittance of <15%, which can realize light-blocking function in the full wavelength range of 290-450 nm, meet the requirements of bag light-blocking, and has good safety performance without adding other additives; the polarity of the vinyl acetate in the EVA structure is similar to that of the EVOH structure of the barrier layer, and has high connection strength, effectively avoiding the delamination problem of the light-blocking and barrier type film with multiple layers.

[0028] 4. The inner adhesive layer is made of EVA, which has similar structure to the EVOH of the barrier layer, high connection strength, and good adhesive function, and on the other hand, the material of the inner adhesive layer is consistent with the material of the inner layer, which is equivalent to increasing the thickness of the inner layer, improving the safety of the liquid contact layer, and avoiding the migration of small molecules in the modified material to the inside of the bag.

[0029] 5. The EVA material is one of the components of the inner adhesive layer or the light-blocking adhesive layer, which has high adhesive strength, can meet the safety requirements of the multi-layer structure, and can avoid the use of modified adhesive resin, thereby reducing the use of small molecules from the source and improving the safety of the intravenous nutrition bag.

[0030] 6. The intravenous nutrition bag provided by the present application has a simple structure, the lower end of the bag body is only provided with a liquid inlet end and a liquid outlet end, the canning device is communicated with the liquid inlet pipeline, the bag body is communicated with the sealing end, and the two passages are arranged in the liquid inlet pipeline, the opening and closing of the two passages and the size of the liquid flow are controlled by the pipeline locking member, so that the filling of the liquid is controlled, and the liquid filling is simple and reliable; after the liquid is filled, the sealing is performed in the form of heat sealing, and the separation of the liquid inlet pipeline and the bag body is completed after the sealing, which simplifies the parts on the liquid inlet pipeline, greatly reduces the material cost and assembly cost of the product.

[0031] 7. The heat-sealed end of the intravenous nutrition bag can be on the catheter connected with the bag body or on the liquid inlet pipeline between the bag body and the two ways, which is various and convenient to use; the inner layer of the bag body adopts EVA material, can be heat-sealed by high-frequency welding or hot welding, is convenient for different production scenes and convenient to use.

[0032] 8. The outer layer of the bag body film layer of the intravenous nutrition bag is a protective layer, which has the functions of protecting the bag body and printing identification, adopts polyolefin PE and PP as the materials, can improve the softness of the bag body; adopts PET and PA as the materials, etc., can improve the barrier effect of the bag body, ensure the mechanical properties of the bag body, can control the total layer thickness of the light-blocking barrier type film, and reduce the production cost.

[0033] 9. The inner layer, the secondary inner layer and the secondary outer layer of the bag body only include EVA, EVOH and PP, the materials are simple and the cost is low; the PP material with relatively low adhesion is combined with the heat-set adhesive EVA, the other layers have certain adhesion in a hot state, the multi-layer structure of the bag body is firmly bonded and is not easy to be layered; the PP has excellent chemical resistance, fatigue resistance and heat resistance, can be sterilized at a temperature above 100 DEG C, avoids the pollution of the drug solution caused by the melting or decomposition of the bag body close to the drug solution during high-temperature disinfection; the intravenous nutrition bag provided by the application is safe and reliable, avoids problems such as poor heat resistance of PE material, high permeability of COC material, high price of other medical plastics, drug corrosion, and many heat-sealed migration substances.

[0034] 10. The light-blocking barrier type intravenous nutrition bag provided by the application can maintain good mechanical properties under the condition that the thickness of the bag body film layer can be controlled.

[0035] 11. The inner layer, the inner bonding layer and the light-blocking bonding layer adopt ethylene-vinyl acetate copolymer (EVA), the inner layer ensures the flexibility and chemical resistance of the bag body by controlling the content of vinyl acetate; the inner bonding layer has good physical bonding capacity and is consistent with the material of the inner layer, has intermolecular forces between the layer films, and is firmly bonded; the light-blocking bonding layer has bonding function and can ensure uniform dispersion of polypropylene, and has stable and reliable light-blocking performance. BRIEF DESCRIPTION OF DRAWINGS

[0036] The foregoing and other objects, features and advantages of the present application will become apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the accompanying drawings.

[0037] Figure 1 It is a structural schematic diagram of the prior art intravenous nutrition bag;

[0038] Figure 2 It is a film layer structure schematic diagram of the light-blocking barrier type film used in the bag body of the intravenous nutrition bag of the application;

[0039] Figure 3This is a schematic diagram of the intravenous nutrition bag in Example 1;

[0040] Figure 4 This is a schematic diagram of the intravenous nutrition bag in Example 2;

[0041] Wherein: 1 is the bag hanging hole, 2 is the bag body, 21 is the inner layer, 22 is the inner adhesive layer, 23 is the barrier layer, 24 is the light-proof adhesive layer, 25 is the outer layer, 3 is the infusion tubing, 4 is the infusion port, 5 is the sealing end, 5a is the first seal, 5b is the second seal, 6 is the tubing locking component, 7 is the two-way connector, and 8 is the inlet tubing. Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0043] Example 1

[0044] A light-blocking intravenous nutrition bag, such as Figure 2 As shown, the device includes a bag body 2, with an inlet end and an outlet end at the lower end. The bag body 2 is made of a light-blocking membrane layer. The outlet end includes an outlet pipe 3 and an outlet port 4. The inlet end includes a sealing end 5 connected to the bag body 2, an inlet pipe 8 connected to the filling device, and a two-way connector 7 connecting the inlet pipe 8 and the first seal 5a. A pipe locking element 6 is provided at the two-way connector 7. The sealing end 5 is located between the bag body 2 and the two-way connector 7. The first seal 5a is essentially a conduit connected to the bag body 2, which forms a heat-sealed port A after subsequent liquid filling, i.e., seal A. The outlet port 4 is located at the end of the inlet pipe 3. The bag body 2 also has a bag hanging hole 1.

[0045] like Figure 3 As shown, the light-blocking barrier film includes an inner layer 21, a secondary inner layer, a secondary outer layer, and an outer layer 25 from the inside out. The secondary inner layer is an inner adhesive layer 22, and the secondary outer layer includes a barrier layer 23 near the secondary inner layer and a light-blocking adhesive layer 24 near the outer layer 25. The inner layer is made of ethylene-vinyl acetate copolymer (EVA), the inner adhesive layer is made of ethylene-vinyl acetate copolymer (EVA), the barrier layer is made of ethylene-vinyl alcohol copolymer (EVOH), and the light-blocking adhesive layer is composed of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP). The outer layer is made of polypropylene (PP).

[0046] The total thickness of the light-blocking barrier film is 0.08mm-0.50mm; in this embodiment, 0.08mm is preferred, and the thicknesses of the inner layer, inner adhesive layer, barrier layer, light-blocking adhesive layer, and outer layer are 22%, 10%, 8%, 30%, and 30%, respectively.

[0047] The inner layer material ethylene-vinyl acetate copolymer (EVA) contains 12-28% of vinyl acetate; the inner adhesive layer material ethylene-vinyl acetate copolymer (EVA) contains 18-40% of vinyl acetate; the light-proof adhesive layer material ethylene-vinyl acetate copolymer (EVA) contains 18-40% of vinyl acetate; the mass ratio of ethylene-vinyl acetate copolymer (EVA) to polypropylene (PP) in the light-proof adhesive layer material is 1:1.1, and the light-proof barrier film prepared has a light transmittance of 13%.

[0048] The manufacturing method of the light-proof barrier type intravenous nutrition bag comprises the following steps:

[0049] Step S1, light-proof barrier film raw material preparation: ethylene-vinyl acetate copolymer (EVA) for the inner layer, ethylene-vinyl acetate copolymer (EVA) for the inner adhesive layer, ethylene-vinyl alcohol copolymer (EVOH) for the barrier layer, a blend of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP) for the light-proof adhesive layer, and outer layer material for the outer layer are respectively placed in a preparation table; wherein the ethylene-vinyl acetate copolymer, ethylene-vinyl alcohol copolymer, polypropylene and outer layer material are respectively pretreated before being added to the preparation table, and the pretreatment process is as follows: the materials to be pretreated are respectively added to an organic solvent, ultrasonic immersion is performed, after the organic solvent is removed, the pretreated materials are vacuum dried to complete the preliminary pretreatment; the materials after the preliminary pretreatment are soaked in water, ultrasonic oscillation is performed for 1-3h, and vacuum drying is performed after the water is removed.

[0050] The organic solvent used in the pretreatment of the ethylene-vinyl acetate copolymer (EVA) is N,N-dimethylformamide (DMF); the organic solvent used in the pretreatment of the ethylene-vinyl alcohol copolymer (EVOH) is N,N-dimethylformamide (DMF); the organic solvent used in the pretreatment of the polypropylene (PP) is a mixed solution of ethanol and acetone;

[0051] Step S2, preparation of the light-proof barrier film: a vacuum suction machine respectively sucks the raw materials in the preparation table into the hopper of a multi-hole extruder, and a light-proof barrier film is produced through co-extrusion film blowing or casting process; the light-proof barrier film is irradiated after being extruded, and the radiation dose of the irradiation is controlled between 5-15Mard; the film layer structure is an inner layer 21 formed by ethylene-vinyl acetate copolymer (EVA), an inner adhesive layer 22 formed by ethylene-vinyl acetate copolymer (EVA), a barrier layer 23 formed by ethylene-vinyl alcohol copolymer (EVOH), a light-proof adhesive layer 24 formed by a blend, and an outer layer 25 formed by outer layer material, which are arranged in this order.

[0052] Step S3, forming the nutrient bag: the light barrier film is wound, gold stamping, heat sealing, cooling, and shaped cutting to obtain the shaped nutrient bag, wherein the gold stamping temperature is 150-180℃, and the pressure is 0.2-0.4Mpa;

[0053] Step S4, the nutrient bag airtightness detection: the shaped nutrient bag body obtained in step S3 is blown into sterile air flow through the sealing end, and the pressure of the sterile air flow is 4-6pa.

[0054] The raw materials are pretreated, washed with organic solvent, washed with water, and then dried before the production of the light barrier film, which can effectively remove small molecules on the surface of the raw materials to prevent the small molecules from adhering to the surface of the raw materials and migrating into the nutrient solution after the bag is formed and the nutrient solution is filled; the irradiation can improve the cross-linking degree between the raw materials and improve the biocompatibility, and also has sterilization function; the nutrient bag is checked for airtightness after preparation, sterile air flow is blown through the sealing end, and the safety and production efficiency during use are reduced.

[0055] Example 2

[0056] As shown in Figure 4 , the difference between the present embodiment and example 1 is that the sealing end 5 is a second sealing end 5b close to the bag body 2 and communicating with the liquid inlet pipeline 8, the second sealing end 5b is between the bag body 2 and the two-way pipe 7, and the heat sealing port B is formed after the tank is filled with liquid, that is, the sealing B.

[0057] Example 3

[0058] The difference between the present embodiment and example 1 is that the material and total thickness of the light barrier film are different, as follows:

[0059] The total thickness of the light barrier film is 0.08mm-0.50mm; the thickness of the inner layer, the inner adhesive layer, the barrier layer, the light blocking adhesive layer and the outer layer is 25%, 10%, 6%, 30% and 29% respectively in the present embodiment.

[0060] The material of the inner layer is ethylene-vinyl acetate copolymer (EVA), the material of the inner adhesive layer is ethylene-vinyl acetate copolymer (EVA), the material of the barrier layer is ethylene-vinyl alcohol copolymer (EVOH), and the material of the light blocking adhesive layer is ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP); the material of the outer layer is polyethylene (PE) and polyamide (PA) with a mass ratio of 1:1.

[0061] The inner layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 12%-28%; the inner adhesive layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 18%-40%; the light-proof adhesive layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 18%-40%; the mass ratio of ethylene-vinyl acetate copolymer (EVA) to polypropylene (PP) in the light-proof adhesive layer material is 1:1.5. The light-proof barrier film prepared in this embodiment has a light transmittance of 10%.

[0062] Example 4

[0063] The difference between this embodiment and Example 1 is that the materials used for the light-proof barrier film and the total thickness of the film are different, and the details are as follows:

[0064] The total thickness of the light-proof barrier film is 0.08mm-0.50mm; preferably 0.4mm in this embodiment, and the thicknesses of the inner layer, the inner adhesive layer, the barrier layer, the light-proof adhesive layer and the outer layer are 20%, 10%, 10%, 35% and 25%, respectively.

[0065] The material of the inner layer is ethylene-vinyl acetate copolymer (EVA), the material of the inner adhesive layer is ethylene-vinyl acetate copolymer (EVA), the material of the barrier layer is ethylene-vinyl alcohol copolymer (EVOH), and the material of the light-proof adhesive layer is composed of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP); the material of the outer layer is a combination of polypropylene (PP) and polyethylene terephthalate (PET) with a mass ratio of 1:1.

[0066] The inner layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 12%-28%; the inner adhesive layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 18%-40%; the light-proof adhesive layer material is ethylene-vinyl acetate copolymer (EVA) with vinyl acetate content of 18%-40%; the mass ratio of ethylene-vinyl acetate copolymer (EVA) to polypropylene (PP) in the light-proof adhesive layer material is 1:2.0, and the light-proof barrier film prepared in this embodiment has a light transmittance of 6%.

[0067] The intravenous nutrition bag provided by the application has simple structure, only liquid inlet end and liquid outlet end are arranged at the lower end of the bag body, the canning device is communicated with the liquid inlet pipeline, the bag body is communicated with the sealing end, the two-way valve is arranged in the liquid inlet pipeline, the opening and closing of the two-way valve and the liquid flow are controlled by the pipeline locking member, so that the filling of the liquid is controlled, and the liquid filling is simple and reliable; after the liquid is canned, the sealing is performed by the heat sealing, the separation of the liquid inlet pipeline and the bag body is completed after the sealing, the structure simplifies the components on the liquid inlet pipeline, and the material cost and assembly cost of the product are greatly reduced; the heat sealing end of the intravenous nutrition bag can be arranged on the catheter connected with the bag body or the liquid inlet pipeline between the bag body and the two-way valve, and the selection is various and the use is convenient; the inner layer of the bag body is made of EVA material, and the heat sealing can be performed by high-frequency welding or hot welding, so that different production scenes are facilitated, and the use is convenient.

[0068] The bag body of the light-blocking type intravenous nutrition bag provided by the application is made of light-blocking type film, the inner layer directly contacted with the liquid is made of EVA material, the material is a long-term clinical infusion material, and the safety of the nutrition bag is ensured; the prepared film layer has a transmittance of less than 15%, can realize light-blocking function in the full wavelength range of 290-450 nm, meets the light-blocking requirement of the bag body, does not need to add other additives, and has good safety performance; the layers are firmly bonded, and there is no delamination problem of the multi-layer structure; the EVA material is used as the inner bonding layer or one component of the light-blocking bonding layer, has high bonding strength, can meet the safety requirement of the multi-layer structure, can avoid the use of modified bonding resin, reduces the use of small molecules from the source, avoids the migration of small molecules to the inside of the bag body, and improves the safety of the intravenous nutrition bag.

[0069] Based on the above ideal embodiments according to the application, the related personnel can make various changes and modifications without deviating from the technical idea of the application. The technical scope of the application is not limited to the contents in the specification, and must be determined according to the scope of claims.

Claims

1. A light-shielding barrier type intravenous feeding bag comprising a bag body (2) provided with a liquid inlet end and a liquid outlet end at a lower end thereof, characterized in that, The bag body (2) is made of a light-blocking barrier film; the liquid inlet end comprises a sealing end (5) communicated with the bag body (2), a liquid inlet pipeline (8) communicated with a filling device, and a two-way pipe (7) connecting the liquid inlet pipeline (8) and the sealing end (5), and a pipeline locking member (6) is arranged at the two-way pipe; the sealing end (5) is arranged between the bag body (2) and the two-way pipe (7); The light-blocking barrier film comprises an inner layer (21), an inner adhesive layer (22), a barrier layer (23), a light-blocking adhesive layer (24) and an outer layer (25) from inside to outside, the inner layer is made of ethylene-vinyl acetate copolymer (EVA), the inner adhesive layer is made of ethylene-vinyl acetate copolymer (EVA), the barrier layer is made of ethylene-vinyl alcohol copolymer (EVOH), and the light-blocking adhesive layer is made of a blend of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP); the mass ratio of ethylene-vinyl acetate copolymer (EVA) to polypropylene (PP) in the light-blocking adhesive layer is 1: (1.1-2.5).

2. The light barrier type of a venous nutrition bag according to claim 1, wherein: The outer layer is made of one or more of polyethylene (PE), polypropylene (PP), polyethylene terephthalate (PET) and polyamide (PA).

3. The light barrier type parenteral nutrition bag according to claim 1, characterized by: The total thickness of the light-blocking barrier film is 0.08-0.50 mm, and the thickness of the inner layer, the inner adhesive layer, the barrier layer, the light-blocking adhesive layer and the outer layer accounts for 20-40%, 10-25%, 6-20%, 30-50% and 25-40% of the total thickness of the light-blocking barrier film respectively.

4. The light barrier type of a venous nutrition bag according to claim 1, wherein: The content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the inner layer is 12-28%, the content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the inner adhesive layer is 18-40%, and the content of vinyl acetate in the ethylene-vinyl acetate copolymer (EVA) of the light-blocking adhesive layer is 18-40%.

5. The light barrier type parenteral nutrition bag according to claim 1, characterized by: The liquid outlet end comprises a liquid outlet pipeline (3) and a liquid outlet spout (4), and the liquid outlet spout (4) is arranged at the end of the liquid outlet pipeline (3); The bag body is further provided with a bag hanging hole (1).

6. The manufacturing method of the light-blocking barrier intravenous nutrition bag according to any one of claims 1-5, comprising the following steps: Step S1, light-blocking barrier film raw material preparation: ethylene-vinyl acetate copolymer (EVA) for the inner layer, ethylene-vinyl acetate copolymer (EVA) for the inner adhesive layer, ethylene-vinyl alcohol copolymer (EVOH) for the barrier layer, a blend of ethylene-vinyl acetate copolymer (EVA) and polypropylene (PP) for the light-blocking adhesive layer, and outer layer material for the outer layer are respectively placed on a material preparation table. Step S2, preparation of light-shielding barrier film: a vacuum suction machine respectively sucks the raw materials on the preparation table into the hopper of the porous extruder, and produces the light-shielding barrier film through co-extrusion blown film or casting process, and the light-shielding barrier film is irradiated after extrusion; the film layer structure is arranged in the order of an inner layer (21) formed by ethylene-vinyl acetate copolymer (EVA), an inner adhesive layer (22) formed by ethylene-vinyl acetate copolymer (EVA), a barrier layer (23) formed by ethylene-vinyl alcohol copolymer (EVOH), a light-shielding adhesive layer (24) formed by a blend, and an outer layer (25) formed by an outer layer material, and the prepared light-shielding barrier film is wound; Step S3, forming of nutrient bag: the light-shielding barrier film roll is unwound, gold stamping, heat sealing, cooling, and special-shaped cutting to obtain a formed nutrient bag; Step S4, air tightness detection of nutrient bag: the formed nutrient bag body prepared in step S3 is blown with sterile gas flow through the sealing end.

7. The light barrier type parenteral nutrition bag according to claim 6, characterized by: The radiation dose of the irradiation in step S2 is 5-15 Mard; the gold stamping temperature in step S3 is 150-180℃, and the pressure is 0.2-0.4 Mpa; and the pressure of the sterile gas flow blown in step S4 is 4-6 pa.

8. The light barrier type parenteral nutrition bag according to claim 6, wherein: The ethylene-vinyl acetate copolymer, ethylene-vinyl alcohol copolymer, polypropylene, and outer layer material are pretreated before use, and the pretreatment process is as follows: the material to be pretreated is added to an organic solvent, ultrasonic immersion, and after removing the organic solvent, the pretreated material is vacuum dried to complete the preliminary pretreatment; the material after the preliminary pretreatment is soaked in water, ultrasonic oscillation for 1-3 h, and vacuum drying after removing the water.

9. The light barrier type parenteral nutrition bag according to claim 8, characterized by: The organic solvent used in the pretreatment of the ethylene-vinyl acetate copolymer (EVA) is N,N-dimethylformamide (DMF); the organic solvent used in the pretreatment of the ethylene-vinyl alcohol copolymer (EVOH) is N,N-dimethylformamide (DMF); and the organic solvent used in the pretreatment of the polypropylene (PP) is a mixed solution of ethanol and acetone.

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