Flexible nano-coating mask paste and preparation method thereof

Abstract

The invention discloses a flexible nano-coating mask paste and a preparation method thereof, and belongs to the technical field of daily cosmetics. The preparation method of the mask comprises the following steps: firstly, preparing a composite fiber solution by taking sodium alginate, chitosan and polycaprolactone as raw materials, and preparing the flexible layer through electrostatic spinning and crosslinking; the preparation method comprises the following steps: firstly, preparing a flexible layer, then preparing a nano conductive suspension by taking a carbon nano tube as a raw material, activating the flexible layer, and coating the activated flexible layer with the nano conductive suspension and smearing the hydrogel loaded with essence by adopting an impregnation method to obtain the flexible nano coating mask. The prepared flexible nano-coating mask has good skin-friendly performance and electrical conductivity, and can promote the absorption of the skin to nutritional ingredients.

Description

Technical Field

[0001] The present invention belongs to the technical field of daily-use cosmetics, and particularly relates to a flexible nano-coated facial mask sticker and a preparation method thereof. Background Art

[0002] In today's society, people's attention to skin care is increasing day by day. As the largest organ of the human body, the skin is not only a protective barrier of the body, but also an important part of personal external image. With the improvement of living standards and the popularization of health and beauty awareness, consumers' demand for skin care is constantly increasing. As an efficient and targeted skin care product, facial masks play a crucial role in the daily-use cosmetics market.

[0003] Consumers' requirements for the performance of facial masks are becoming increasingly diverse. In addition to the traditional basic functions such as moisturizing, whitening, and repair, they also pursue a more comfortable and fitting use experience. In the fast-paced life, consumers hope that facial masks can provide sufficient nutrition for the skin in a short time without bringing too much burden to the skin. Therefore, the present invention develops a flexible nano-coated facial mask sticker and a preparation method thereof to solve the technical problems of poor skin affinity and conductivity of facial mask stickers in the prior art, thereby enhancing the effect when used with a matching facial mask instrument. Summary of the Invention

[0004] The purpose of the present invention is to provide a flexible nano-coated facial mask sticker and a preparation method thereof to solve the technical problems of poor skin affinity and conductivity of facial mask stickers in the prior art, thereby enhancing the effect when used with a matching facial mask instrument.

[0005] To achieve the above purpose, the present invention adopts the following technical solutions: A preparation method of a flexible nano-coated facial mask sticker, comprising the following steps: (1) Using sodium alginate, chitosan, and polycaprolactone as raw materials, preparing a composite fiber solution, and obtaining a flexible layer through electrospinning and crosslinking; (2) Using carbon nanotubes as raw materials, preparing a nano-conductive suspension. At the same time, activating the flexible layer, and coating the activated flexible layer with the nano-conductive suspension and applying a hydrogel loaded with essence to obtain a flexible nano-coated facial mask sticker.

[0006] Further, the preparation method of the flexible nano-coated facial mask sticker, step (1) includes the following process: S1. Preparing an aqueous sodium alginate solution, a chitosan acetate solution, and a polycaprolactone solution, mixing the solutions to obtain a mixed solution, adding poly(N-isopropylacrylamide), glycerol, and Tween-80 to the mixed solution, and stirring evenly to obtain a composite fiber solution; S2. Electrospin the composite fiber solution to obtain a flexible layer. Immerse the flexible layer in a calcium chloride solution for crosslinking. After completion, wash it, and then immerse it in a glutaraldehyde solution for crosslinking to obtain a flexible layer.

[0007] Further, in S1, the sodium alginate aqueous solution is obtained by dissolving 2 - 5 g of sodium alginate in 100 - 200 mL of deionized water; the chitosan acetate solution is obtained by dissolving 1 - 3 g of chitosan in 100 - 200 mL of 1 vt% acetic acid solution; the polycaprolactone solution is obtained by dissolving 3 - 6 g of polycaprolactone in a mixed solution of 100 - 200 mL of dichloromethane and N,N - dimethylformamide, where the volume ratio of dichloromethane to N,N - dimethylformamide is 3:1; the volume ratio of the sodium alginate aqueous solution, the chitosan acetate solution, and the polycaprolactone solution is 3:2:1, and the dosage ratio of poly(N - isopropylacrylamide), glycerol, Tween - 80, and the mixed solution is 0.1 - 0.5 g:0.2 - 2 g:0.1 - 0.3 g:100 mL; in S2, the voltage is 15 - 25 kV, the feeding speed is 0.5 - 1.5 mL / h, the distance between the receiving plate and the syringe needle is 10 - 20 cm, the spinning time is 2 - 4 h, the mass concentration of the calcium chloride solution is 2 - 5 wt%, and the mass concentration of the glutaraldehyde solution is 0.1 - 1 wt%.

[0008] Further, for the preparation method of the flexible nano - coated facial mask sticker, step (2) includes the following process: Q1. Disperse carbon nanotubes and sodium dodecyl sulfate in deionized water to obtain a nano - conductive suspension; clean the flexible layer with deionized water, then immerse it in dilute hydrochloric acid, wash it, and dry it to obtain an activated flexible layer; immerse the activated flexible layer in the nano - conductive suspension, and after completion, air - dry it vertically to obtain a conductive flexible layer; Q2. Dissolve polyethylene glycol dimethacrylate in deionized water, add 2 - hydroxy - 4'-(2 - hydroxyethoxy)-2 - methylpropiophenone, and stir evenly to obtain a photo - crosslinkable hydrogel solution. Disperse nano - silver particles and nano - titanium dioxide in the photo - crosslinkable hydrogel solution, irradiate it with ultraviolet light to obtain a hydrogel, then immerse it in the essence solution to obtain a hydrogel loaded with the essence solution, and evenly apply the hydrogel loaded with the essence solution on the surface of the conductive flexible layer to obtain the flexible nano - coated facial mask sticker.

[0009] Further, the dosage ratio of carbon nanotubes, sodium dodecyl sulfate and deionized water in Q1 is 0.1 - 0.5 g: 0.05 - 0.1 g: 100 mL; the concentration of dilute hydrochloric acid is 0.1 - 0.5 mol / L, the soaking time is 10 - 30 min, and the drying temperature is 40 - 60 °C; the dosage ratio of polyethylene glycol dimethacrylate, 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone and deionized water in Q2 is 5 - 10 g: 0.1 - 0.5 g: 100 mL, the particle size of silver nanoparticles is 20 - 50 nm, the particle size of titanium dioxide nanoparticles is 30 - 60 nm, the mass ratio of silver nanoparticles to titanium dioxide nanoparticles is 1:1, the dosage ratio of silver nanoparticles to the photocrosslinkable hydrogel solution is 0.25 - 0.5 g: 100 mL, the essence is prepared by mixing sodium hyaluronate, magnesium ascorbyl phosphate nanoscale, niacinamide, ceramide and deionized water according to a mass ratio of 1.5 - 2: 2 - 3: 1.5 - 2: 0.8 - 1: 60 - 80, the dosage ratio of the essence to the hydrogel is 1 - 2 g: 1 mL, the ultraviolet light intensity is 10 - 20 mW / cm², the irradiation time is 5 - 10 min, and the coating thickness is 0.1 - 0.5 mm.

[0010] In summary, due to the adoption of the above technical solutions, the beneficial effects of the present invention are as follows: 1. The present invention uses sodium alginate, chitosan and polycaprolactone as raw materials to prepare a flexible layer as the basic support structure of the facial mask; the coated nano-conductive suspension and the hydrogel loaded with essence are tightly combined with the flexible layer, so that the facial mask can maintain good shape and stability during the application process.

[0011] 2. The present invention obtains a flexible layer with good flexibility and skin-friendly property through the combined action of sodium alginate, chitosan and polycaprolactone; in addition, the addition of poly(N-isopropylacrylamide) can adjust the component release according to the skin temperature. When the facial mask contacts the skin, the molecular conformation of poly(N-isopropylacrylamide) changes, thereby changing the microstructure and performance of the facial mask, realizing intelligent controlled release and improving the skin care effect.

[0012] 3. The present invention promotes electron transfer through the unique structure of carbon nanotubes, enhances the metabolism of skin cells and the absorption of nutrients, and the active groups introduced by the activation treatment can enhance the binding force between carbon nanotubes and the flexible layer through hydrogen bonds, electrostatic attraction, etc., making the conductive performance more stable; polyethylene glycol dimethacrylate forms a hydrogel by ultraviolet crosslinking under the action of a photoinitiator. Its good hydrophilicity can absorb and retain a large amount of water and essence. Among them, silver nanoparticles have antibacterial properties, titanium dioxide nanoparticles have sunscreen properties, and are combined with components such as sodium hyaluronate for moisturizing, magnesium ascorbyl phosphate nanoscale for whitening and antioxidant, niacinamide for whitening, and ceramide for repairing the skin barrier in the essence. Under the loading of the hydrogel, they jointly provide comprehensive care for the skin. Detailed implementation manners

[0013] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention. Embodiment 1:

[0014] This embodiment provides a preparation method of a flexible nano-coated facial mask sticker, including the following steps: (1) Using sodium alginate, chitosan and polycaprolactone as raw materials, a composite fiber solution is prepared, and a flexible layer is obtained through electrospinning and crosslinking; (2) Using carbon nanotubes as raw materials, a nano-conductive suspension is prepared. At the same time, the flexible layer is activated, and the activated flexible layer is coated with the nano-conductive suspension and smeared with a hydrogel loaded with essence to obtain a flexible nano-coated facial mask sticker.

[0015] Among them, for the preparation method of the flexible nano-coated facial mask sticker, step (1) includes the following process: S1. Prepare 200 mL of sodium alginate aqueous solution, 200 mL of chitosan acetate solution and 200 mL of polycaprolactone solution. The sodium alginate aqueous solution is obtained by dissolving 2 g of sodium alginate in 200 mL of deionized water; the chitosan acetate solution is obtained by dissolving 1 g of chitosan in 100 mL of acetic acid solution with a concentration of 1 vt%; the polycaprolactone solution is obtained by dissolving 3 g of polycaprolactone in a mixed solution of 200 mL of dichloromethane and N,N-dimethylformamide, where the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1; the sodium alginate aqueous solution, chitosan acetate solution and polycaprolactone solution are mixed according to a volume ratio of 3:2:1 to obtain a mixed solution, and 0.1 g of poly(N-isopropylacrylamide), 0.2 g of glycerol and 0.1 g of Tween-80 are added to 100 mL of the mixed solution, and stirred evenly to obtain a composite fiber solution; S2. Electrospin the composite fiber solution with a voltage of 15 kV, a feeding speed of 0.5 mL / h, a distance between the receiving plate and the syringe needle of 10 cm, and a spinning time of 2 h to obtain a flexible layer. The flexible layer is soaked in a calcium chloride solution for crosslinking, the mass concentration of the calcium chloride solution is 2 wt%, after completion, it is washed, and then soaked in a glutaraldehyde solution for crosslinking, the mass concentration of the glutaraldehyde solution is 0.1 wt% to obtain a flexible layer.

[0016] Among them, for the preparation method of the flexible nano-coated facial mask sticker, step (2) includes the following process: Q1. Disperse 0.1 g of carbon nanotubes and 0.05 g of sodium dodecyl sulfate in 100 mL of deionized water to obtain a nano-conductive suspension; clean the flexible layer with deionized water, then soak it in 0.1 mol / L dilute hydrochloric acid for 10 min, wash, and dry at a temperature of 40 °C to obtain an activated flexible layer; soak the activated flexible layer in the nano-conductive suspension for 10 min, and after that, air-dry it vertically to obtain a conductive flexible layer; Q2. Dissolve 5 g of polyethylene glycol dimethacrylate in 100 mL of deionized water, add 0.1 g of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, stir evenly to obtain a photo-crosslinkable hydrogel solution. Disperse 0.25 g of nano silver particles and 0.25 g of nano titanium dioxide in 100 mL of the photo-crosslinkable hydrogel solution, irradiate with ultraviolet light at an ultraviolet light intensity of 10 mW / cm² for 5 min to obtain a hydrogel, and then soak it in the essence. The dosage ratio of the essence to the hydrogel is 1 g:1 mL. The essence is prepared by mixing sodium hyaluronate, nano magnesium ascorbyl phosphate, niacinamide, ceramide and deionized water according to a mass ratio of 1.5:2:1.5:0.8:80 to obtain a hydrogel loaded with the essence. Apply the hydrogel loaded with the essence evenly on the surface of the conductive flexible layer with a coating thickness of 0.1 mm to obtain a flexible nano-coated facial mask sticker. Example 2:

[0017] This example provides a preparation method of a flexible nano-coated facial mask sticker, including the following steps: (1) Using sodium alginate, chitosan and polycaprolactone as raw materials, prepare a composite fiber solution, and through electrospinning and crosslinking, prepare a flexible layer; (2) Using carbon nanotubes as raw materials, prepare a nano-conductive suspension. At the same time, activate the flexible layer, and coat the activated flexible layer with the nano-conductive suspension and apply the hydrogel loaded with the essence to obtain a flexible nano-coated facial mask sticker.

[0018] Among them, the preparation method of the flexible nano-coated facial mask sticker, step (1) includes the following process: S1. Prepare 180 mL of sodium alginate aqueous solution, 180 mL of chitosan acetate solution, and 180 mL of polycaprolactone solution. The sodium alginate aqueous solution is obtained by dissolving 3 g of sodium alginate in 180 mL of deionized water; the chitosan acetate solution is obtained by dissolving 1.5 g of chitosan in 180 mL of 1 vt% acetic acid solution; the polycaprolactone solution is obtained by dissolving 3.5 g of polycaprolactone in a mixture of 180 mL of dichloromethane and N,N-dimethylformamide, where the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1. Mix the sodium alginate aqueous solution, chitosan acetate solution, and polycaprolactone solution in a volume ratio of 3:2:1 to obtain a mixed solution. Add 0.2 g of poly(N-isopropylacrylamide), 0.4 g of glycerol, and 0.15 g of Tween-80 to 100 mL of the mixed solution, and stir evenly to obtain a composite fiber solution. S2. Electrospin the composite fiber solution with a voltage of 18 kV, a feeding rate of 0.8 mL / h, a distance between the receiving plate and the syringe needle of 12 cm, and a spinning time of 3 h to obtain a flexible layer. Immerse the flexible layer in a calcium chloride solution for crosslinking, where the mass concentration of the calcium chloride solution is 3 wt%. After that, wash it and then immerse it in a glutaraldehyde solution for crosslinking, where the mass concentration of the glutaraldehyde solution is 0.3 wt% to obtain a flexible layer.

[0019] Among them, the preparation method of the flexible nano-coated surface film sticker, step (2) includes the following process: Q1. Disperse 0.2 g of carbon nanotubes and 0.06 g of sodium dodecyl sulfate in 100 mL of deionized water to obtain a nano-conductive suspension; clean the flexible layer with deionized water, then immerse it in 0.2 mol / L dilute hydrochloric acid for 14 min, wash it, and dry it at a temperature of 45 °C to obtain an activated flexible layer; immerse the activated flexible layer in the nano-conductive suspension for 15 min, and then vertically air-dry it to obtain a conductive flexible layer. Q2. Dissolve 6 g of polyethylene glycol dimethacrylate in 100 mL of deionized water, add 0.2 g of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, stir evenly to obtain a photocrosslinkable hydrogel solution. Disperse 0.3 g of silver nanoparticles and 0.3 g of titanium dioxide nanoparticles in 100 mL of the photocrosslinkable hydrogel solution, irradiate with ultraviolet light at an ultraviolet light intensity of 12 mW / cm² for 6 min to obtain a hydrogel, and then soak it in the essence. The dosage ratio of the essence to the hydrogel is 1.2 g:1 mL. The essence is prepared by mixing sodium hyaluronate, magnesium ascorbyl phosphate at the nanoscale, niacinamide, ceramide and deionized water according to a mass ratio of 1.6:2.2:1.6:0.85:75 to obtain a hydrogel loaded with the essence. Apply the hydrogel loaded with the essence evenly on the surface of the conductive flexible layer with a coating thickness of 0.2 mm to obtain a flexible nano-coated facial mask sticker. Example 3:

[0020] This example provides a method for preparing a flexible nano-coated facial mask sticker, which includes the following steps: (1) Using sodium alginate, chitosan and polycaprolactone as raw materials, prepare a composite fiber solution, and obtain a flexible layer through electrospinning and crosslinking; (2) Using carbon nanotubes as raw materials, prepare a nano-conductive suspension. At the same time, activate the flexible layer, and coat the activated flexible layer with the nano-conductive suspension and apply the hydrogel loaded with the essence to obtain a flexible nano-coated facial mask sticker.

[0021] Among them, the preparation method of the flexible nano-coated facial mask sticker in step (1) includes the following process: S1. Prepare an aqueous sodium alginate solution, a chitosan acetate solution and a polycaprolactone solution. The aqueous sodium alginate solution is obtained by dissolving 3 g of sodium alginate in 160 mL of deionized water; the chitosan acetate solution is obtained by dissolving 2 g of chitosan in 160 mL of 1 vt% acetic acid solution; the polycaprolactone solution is obtained by dissolving 4 g of polycaprolactone in a mixed solution of 160 mL of dichloromethane and N,N-dimethylformamide, where the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1; mix the aqueous sodium alginate solution, the chitosan acetate solution and the polycaprolactone solution according to a volume ratio of 3:2:1 to obtain a mixed solution, add 0.3 g of poly(N-isopropylacrylamide), 0.5 g of glycerol and 0.2 g of Tween-80 to 100 mL of the mixed solution, and stir evenly to obtain a composite fiber solution; S2. Electrospin the composite fiber solution at a voltage of 19 kV, a feeding rate of 0.9 mL / h, a distance between the receiving plate and the syringe needle of 15 cm, and a spinning time of 3 h to obtain a flexible layer. Immerse the flexible layer in a calcium chloride solution for crosslinking, where the mass concentration of the calcium chloride solution is 2.5 wt%. After that, wash it and then immerse it in a glutaraldehyde solution for crosslinking, where the mass concentration of the glutaraldehyde solution is 0.4 wt% to obtain a flexible layer.

[0022] Among them, the preparation method of the flexible nano-coated facial mask sticker, step (2) includes the following process: Q1. Disperse 0.3 g of carbon nanotubes and 0.07 g of sodium dodecyl sulfate in 100 mL of deionized water to obtain a nano-conductive suspension; clean the flexible layer with deionized water, then immerse it in 0.3 mol / L dilute hydrochloric acid for 18 min, wash it, and dry it at a drying temperature of 48 °C to obtain an activated flexible layer; immerse the activated flexible layer in the nano-conductive suspension for 18 min, and after that, air-dry it vertically to obtain a conductive flexible layer. Q2. Dissolve 7 g of polyethylene glycol dimethacrylate in 100 mL of deionized water, add 0.3 g of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and stir evenly to obtain a photo-crosslinkable hydrogel solution. Disperse 0.3 g of nano-silver particles and 0.3 g of nano-titanium dioxide in 100 mL of the photo-crosslinkable hydrogel solution, and irradiate it with ultraviolet light at an ultraviolet light intensity of 16 mW / cm² for 7 min to obtain a hydrogel. Then immerse it in the essence, where the dosage ratio of the essence to the hydrogel is 1.4 g:1 mL. The essence is prepared by mixing sodium hyaluronate, nano-scale magnesium ascorbyl phosphate, niacinamide, ceramide, and deionized water according to a mass ratio of 1.7:2.5:1.7:0.9:70 to obtain a hydrogel loaded with the essence. Apply the hydrogel loaded with the essence evenly on the surface of the conductive flexible layer with a coating thickness of 0.3 mm to obtain a flexible nano-coated facial mask sticker. Example 4:

[0023] This example provides a preparation method of a flexible nano-coated facial mask sticker, including the following steps: (1) Use sodium alginate, chitosan, and polycaprolactone as raw materials to prepare a composite fiber solution, and prepare a flexible layer through electrospinning and crosslinking. (2) Use carbon nanotubes as raw materials to prepare a nano-conductive suspension. At the same time, activate the flexible layer, and coat the activated flexible layer with the nano-conductive suspension and apply the hydrogel loaded with the essence to obtain a flexible nano-coated facial mask sticker.

[0024] Among them, the preparation method of the flexible nano-coated facial mask sticker, step (1) includes the following process: S1. Prepare an aqueous sodium alginate solution, a chitosan acetate solution, and a polycaprolactone solution. The aqueous sodium alginate solution is obtained by dissolving 4 g of sodium alginate in 140 mL of deionized water; the chitosan acetate solution is obtained by dissolving 2.5 g of chitosan in 140 mL of 1 vt% acetic acid solution; the polycaprolactone solution is obtained by dissolving 5 g of polycaprolactone in a mixture of 140 mL of dichloromethane and N,N-dimethylformamide, where the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1. Mix the aqueous sodium alginate solution, the chitosan acetate solution, and the polycaprolactone solution in a volume ratio of 3:2:1 to obtain a mixed solution. Add 0.4 g of poly(N-isopropylacrylamide), 1.5 g of glycerol, and 0.25 g of Tween-80 to 100 mL of the mixed solution, and stir evenly to obtain a composite fiber solution. S2. Electrospin the composite fiber solution at a voltage of 20 kV, a feeding rate of 1 mL / h, a distance between the receiving plate and the syringe needle of 18 cm, and a spinning time of 3 h to obtain a flexible layer. Immerse the flexible layer in a calcium chloride solution for crosslinking, where the mass concentration of the calcium chloride solution is 4 wt%. After that, wash it and then immerse it in a glutaraldehyde solution for crosslinking, where the mass concentration of the glutaraldehyde solution is 0.8 wt% to obtain a flexible layer.

[0025] Among them, the preparation method of the flexible nano-coated facial mask sticker, step (2) includes the following process: Q1. Disperse 0.4 g of carbon nanotubes and 0.08 g of sodium dodecyl sulfate in 100 mL of deionized water to obtain a nano-conductive suspension. Wash the flexible layer with deionized water, then immerse it in 0.4 mol / L dilute hydrochloric acid for 20 min, wash it, and dry it at a temperature of 50 °C to obtain an activated flexible layer. Immerse the activated flexible layer in the nano-conductive suspension for 20 min, and then air-dry it vertically to obtain a conductive flexible layer. Q2. Dissolve 8 g of polyethylene glycol dimethacrylate in 100 mL of deionized water, add 0.4 g of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and stir evenly to obtain a photo-crosslinkable hydrogel solution. Disperse 0.4 g of nano-silver particles and 0.4 g of nano-titanium dioxide in 100 mL of the photo-crosslinkable hydrogel solution, and irradiate it with ultraviolet light at an ultraviolet light intensity of 18 mW / cm² for 9 min to obtain a hydrogel. Then immerse it in the essence, and the dosage ratio of the essence to the hydrogel is 1.8 g:1 mL. The essence is prepared by mixing sodium hyaluronate, nano-vitamin C magnesium phosphate, niacinamide, ceramide, and deionized water in a mass ratio of 1.9:2.8:1.9:0.95:65 to obtain a hydrogel loaded with the essence. Apply the hydrogel loaded with the essence evenly on the surface of the conductive flexible layer with a coating thickness of 0.4 mm to obtain a flexible nano-coated facial mask sticker. Example 5:

[0026] This example provides a preparation method for a flexible nano-coated facial mask sticker, which includes the following steps: (1) Using sodium alginate, chitosan, and polycaprolactone as raw materials, a composite fiber solution is prepared. Through electrospinning and crosslinking, a flexible layer is obtained; (2) Using carbon nanotubes as raw materials, a nano-conductive suspension is prepared. At the same time, the flexible layer is activated, and the activated flexible layer is coated with the nano-conductive suspension and smeared with a hydrogel loaded with essence to obtain a flexible nano-coated facial mask sticker.

[0027] Among them, for the preparation method of the flexible nano-coated facial mask sticker, step (1) includes the following process: S1. Prepare an aqueous sodium alginate solution, a chitosan acetate solution, and a polycaprolactone solution. The aqueous sodium alginate solution is obtained by dissolving 5 g of sodium alginate in 100 mL of deionized water; the chitosan acetate solution is obtained by dissolving 3 g of chitosan in 100 mL of 1 vt% acetic acid solution; the polycaprolactone solution is obtained by dissolving 6 g of polycaprolactone in a mixed solution of 100 mL of dichloromethane and N,N-dimethylformamide, where the volume ratio of dichloromethane to N,N-dimethylformamide is 3:1. Mix the aqueous sodium alginate solution, the chitosan acetate solution, and the polycaprolactone solution according to a volume ratio of 3:2:1 to obtain a mixed solution. Add 0.5 g of poly(N-isopropylacrylamide), 2 g of glycerol, and 0.3 g of Tween-80 to 100 mL of the mixed solution, and stir evenly to obtain a composite fiber solution; S2. Perform electrospinning on the composite fiber solution with a voltage of 25 kV, a feeding speed of 1.5 mL / h, a distance between the receiving plate and the syringe needle of 20 cm, and a spinning time of 4 h to obtain a flexible layer. Immerse the flexible layer in a calcium chloride solution for crosslinking, where the mass concentration of the calcium chloride solution is 5 wt%. After completion, wash it, and then immerse it in a glutaraldehyde solution for crosslinking, where the mass concentration of the glutaraldehyde solution is 1 wt% to obtain a flexible layer.

[0028] Among them, for the preparation method of the flexible nano-coated facial mask sticker, step (2) includes the following process: Q1. Disperse 0.5 g of carbon nanotubes and 0.1 g of sodium dodecyl sulfate in 100 mL of deionized water to obtain a nano-conductive suspension; wash the flexible layer with deionized water, then immerse it in 0.5 mol / L dilute hydrochloric acid for 30 min, wash it, and dry it at a temperature of 60 °C to obtain an activated flexible layer; immerse the activated flexible layer in the nano-conductive suspension for 30 min, and after completion, air-dry it vertically to obtain a conductive flexible layer; Q2. Dissolve 10 g of polyethylene glycol dimethacrylate in 100 mL of deionized water, add 0.5 g of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, stir evenly to obtain a photocrosslinkable hydrogel solution. Disperse 0.5 g of silver nanoparticles and 0.5 g of titanium dioxide nanoparticles in 100 mL of the photocrosslinkable hydrogel solution, irradiate with ultraviolet light at an ultraviolet light intensity of 20 mW / cm² for 10 min to obtain a hydrogel, and then soak it in the essence. The dosage ratio of the essence to the hydrogel is 2 g:1 mL. The essence is prepared by mixing sodium hyaluronate, magnesium ascorbyl phosphate at the nanoscale, niacinamide, ceramide and deionized water according to a mass ratio of 2:3:2:1:60 to obtain a hydrogel loaded with the essence. Spread the hydrogel loaded with the essence evenly on the surface of the conductive flexible layer with a coating thickness of 0.5 mm to obtain a flexible nanocoated facial mask sticker.

[0029] Comparative Example 1: Compared with Example 3, in the preparation process of the flexible nanocoated facial mask sticker in Comparative Example 1, the composite fiber solution was replaced with a chitosan solution, and other conditions remained unchanged.

[0030] Comparative Example 2: Compared with Example 3, in the preparation process of the flexible nanocoated facial mask sticker in Comparative Example 2, the modification of the flexible layer was not carried out, and other conditions remained unchanged.

[0031] Comparative Example 3: Compared with Example 3, in the preparation process of the flexible nanocoated facial mask sticker in Comparative Example 3, poly(N-isopropylacrylamide) was not added, and other conditions remained unchanged.

[0032] Comparative Example 4: Compared with Example 3, in the preparation process of the flexible nanocoated facial mask sticker in Comparative Example 4, the nanoconductive suspension was not coated, and other conditions remained unchanged.

[0033] Experimental Example: Perform performance measurements on the facial mask sticker samples prepared in the above Examples 1-5 and Comparative Examples 1-4.

[0034] I. Skin-friendly test Test volunteers: Select 54 healthy volunteers who are frequently exposed to sunlight, have yellowish skin, obvious facial wrinkles and poor skin elasticity, with an equal number of men and women. They are randomly divided into 9 groups, with 6 people in each group, and an equal number of men and women.

[0035] Skin irritation test: The mask patches of Examples 1-5 and Comparative Examples 1-4 were respectively cut into small pieces and applied to the inner forearm skin of volunteers, and fixed with breathable tape. The application time was 24 hours, and then the mask patches were removed, and the skin reactions at 0.5 hour and 24 hours after removing the mask patches were observed. Using the Draize scoring method, the erythema and edema were respectively scored from 0 to 4 points, and the sum of the two was the total score. 0 points: no erythema / edema; 1 point: extremely slight erythema / edema; 2 points: slight erythema / edema; 3 points: moderate erythema / edema; 4 points: severe erythema / edema. The average value of each group of data was taken, and the test results are shown in Table 1.

[0036] Skin moisture content test: Symmetrical areas were selected on the faces of volunteers, and the mask patches of Examples 1-5 and Comparative Examples 1-4 were respectively applied. After 20 minutes of application, they were removed. The skin moisture content was measured using a skin moisture tester before application, immediately after removing the mask patches, and 1 hour after removal. The average value of each group of data was taken, and the test results are shown in Table 1.

[0037]

[0038] It can be seen from the test results in Table 1 that Comparative Examples 1-4 and Examples 1-5 are not irritating, indicating that the mask patch materials used are safe; the mask patches prepared in Examples 1-5 have good skin affinity. By comparing Comparative Examples 1-4 and Examples 1-5, it can be known that adding a composite fiber solution, poly(N-isopropylacrylamide), a nano-conductive suspension, and the modification of the flexible layer can effectively improve the skin affinity of the mask patch.

[0039] II. Conductivity test The mask patches of Examples 1-5 and Comparative Examples 1-4 were cut into 5 cm * 5 cm samples, and the conductivity of the mask patches was measured using a conductivity meter. Each sample was measured 3 times, and the average value was taken. The results are shown in Table 2.

[0040]

[0041] It can be seen from the test results in Table 1 that the mask patches prepared in Examples 1-5 have good conductivity. By comparing Comparative Examples 1-4 and Examples 1-5, it can be known that adding a composite fiber solution, a nano-conductive suspension, and the modification of the flexible layer can improve the conductivity of the mask patch.

[0042] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

[0043] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments only. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification to better explain the principles and practical applications of the present invention, so that those skilled in the art can well understand and utilize the present invention. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. A method for preparing a flexible nano-coated facial mask, characterized in that: The following steps are involved: (1) Using sodium alginate, chitosan and polycaprolactone as raw materials, a composite fiber solution was prepared, and a flexible layer was prepared by electrospinning and cross-linking; (2) Using carbon nanotubes as raw materials, a nano-conductive suspension is prepared. At the same time, the flexible layer is activated, and the activated flexible layer is coated with the nano-conductive suspension and the hydrogel loaded with essence to obtain a flexible nano-coated facial mask.

2. The method for preparing the flexible nano-coating facial mask according to claim 1, characterized in that: Step (1) includes the following process: S1, preparing a sodium alginate aqueous solution, a chitosan acetate solution and a polycaprolactone solution, mixing the solutions to obtain a mixed solution, adding poly (N-isopropylacrylamide), glycerol and Tween-80 to the mixed solution, stirring evenly, to obtain a composite fiber solution; S2. Electrostatically spinning the composite fiber solution to obtain a flexible layer, immersing the flexible layer in a calcium chloride solution for cross-linking, washing, and then immersing in a glutaraldehyde solution for cross-linking to obtain a flexible layer.

3. The method for preparing the flexible nano-coating facial mask according to claim 2, characterized in that: The sodium alginate aqueous solution in S1 is obtained by dissolving 2-5g of sodium alginate in 100-200mL of deionized water; the chitosan acetic acid solution is obtained by dissolving 1-3g of chitosan in 1vt% 100-200mL of acetic acid solution; the polycaprolactone solution is obtained by dissolving 3-6g of polycaprolactone in 100-200mL of a mixture of dichloromethane and N,N-dimethylformamide, wherein the volume ratio of dichloromethane to N,N-dimethylformamide is 3:

1.

4. The method for preparing the flexible nano-coating facial mask according to claim 2, characterized in that: The volume ratio of sodium alginate aqueous solution, chitosan acetate solution and polycaprolactone solution in S1 is 3:2:1, and the dosage ratio of poly(N-isopropylacrylamide), glycerol, Tween-80 and mixed solution is 0.1-0.5g:0.2-2g:0.1-0.3g:100mL.

5. The method for preparing the flexible nano-coating facial mask according to claim 2, characterized in that: The mass concentration of the calcium chloride solution in S2 is 2-5wt%, and the mass concentration of the glutaraldehyde solution is 0.1-1wt%.

6. The method for preparing the flexible nano-coating facial mask according to claim 1, characterized in that: Step (2) includes the following process: Q1. Dispersing carbon nanotubes and sodium dodecyl sulfate in deionized water to obtain a nano conductive suspension; cleaning the flexible layer with deionized water, then soaking it in dilute hydrochloric acid, washing, and drying to obtain an activated flexible layer; soaking the activated flexible layer in the nano conductive suspension, and then vertically drying it to obtain a conductive flexible layer; Q2. Dissolve polyethylene glycol dimethacrylate in deionized water, add 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, stir evenly to obtain a photo-cross-linked hydrogel solution, disperse nanosilver particles and nano-titanium dioxide in the photo-cross-linked hydrogel solution, irradiate with ultraviolet light to obtain a hydrogel, and then immerse in essence to obtain an essence-loaded hydrogel, and evenly apply the essence-loaded hydrogel on the surface of the conductive flexible layer to obtain a flexible nano-coated facial mask.

7. The method for preparing the flexible nano-coating facial mask according to claim 6, characterized in that: The usage ratio of carbon nanotubes, sodium dodecyl sulfate and deionized water in Q1 is 0.1-0.5 g: 0.05-0.1 g: 100 mL; the concentration of dilute hydrochloric acid is 0.1-0.5 mol / L.

8. The method for preparing the flexible nano-coating facial mask according to claim 6, characterized in that: The dosage ratio of polyethylene glycol dimethacrylate, 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone and deionized water in Q2 is 5-10g:0.1-0.5g:100mL, the particle size of nanosilver particles is 20-50nm, the particle size of nanotitanium dioxide is 30-60nm, the mass ratio of nanosilver particles and nanotitanium dioxide is 1:1, and the dosage ratio of nanosilver particles to photo-cross-linked hydrogel solution is 0.25-0.5g:100mL.

9. The method for preparing the flexible nano-coating facial mask according to claim 6, characterized in that: The essence in Q2 is prepared by mixing sodium hyaluronate, nano-scale vitamin C magnesium phosphate, niacinamide, ceramide and deionized water in a mass ratio of 1.5-2:2-3:1.5-2:0.8-1:60-80. The dosage ratio of essence to hydrogel is 1-2g:1mL, the ultraviolet light intensity is 10-20mW / cm², the irradiation time is 5-10min, and the application thickness is 0.1-0.5mm.

10. Flexible nano-coated facial mask, characterized in that: The flexible nano-coating facial mask is prepared by the preparation method of the flexible nano-coating facial mask as described in any one of claims 1 to 9.

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