Multi-channel biochemical analysis detector and control method

By designing the fixing unit of a multi-channel biochemical analysis detector, the problem of difficulty in fixing the absolute position of the flexible sensor in the detection device is solved, the precise fixation of the signal interface and the multi-channel input of the signal are realized, and the accuracy and stability of the detection signal are improved.

CN120214288AActive Publication Date: 2025-06-27TAIYUAN UNIVERSITY OF TECHNOLOGY
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Patent Information

Application Number
CN202510455322.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-11
Publication Date
2025-06-27
Estimated Expiration
2045-04-11

AI Technical Summary

Technical Problem

It is difficult for the flexible sensor to fix the absolute position in the detection device, resulting in signal distortion and difficulty in controlling signal accuracy.

Method used

A multi-channel biochemical analysis detector is designed, and a fixed unit is adopted, including a socket, a fixed plane, an in-situ detection module, a connection module, a driving module and a control module. By detecting the signal interface of the in-situ detection module, an in-situ signal is generated. The control drives the connection module to move until it comes into contact with the signal interface and is fixed.

Benefits of technology

It realizes accurate fixation of the biochemical sensing array signal interface, avoids signal displacement, improves signal accuracy and stability, and realizes multi-channel input of the signal.

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Abstract

The invention relates to a multi-channel biochemical analysis detector and a control method, the multi-channel biochemical analysis detector comprises a fixing unit used for fixing a biochemical sensing array signal interface, the fixing unit comprises a socket, a fixing plane, an in-situ detection module, a connection module, a driving module and a control module, the in-place detection module detects that the signal interface is inserted into the socket, generates an in-place signal and transmits the in-place signal to the control module, and the control module responds to the in-place signal and controls the driving module to drive the connecting module to move until the connecting module is in contact with the signal interface to form electric connection and fixes the signal interface on a fixed plane. Therefore, the signal interface of the biochemical sensing array is fixed on the fixed plane in an electric control mode, so that the biochemical sensing array does not displace in the detection process, and the accuracy and the stability of signals are improved; meanwhile, the connecting module is electrically connected with the signal interface, so that the signal of the biochemical sensing array is input into the multi-channel biochemical analysis detector.
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Description

Technical Field

[0001] The present disclosure relates to the technical field of biosensors, and in particular, to a multi-channel biochemical analysis detector and a control method therefor. Background Art

[0002] In recent years, flexible sensors have been widely used in the fields of robot tactile perception, wearable medical devices, and industrial automation due to their advantages such as high flexibility, light weight, and customizable wiring.

[0003] In related technologies, due to the deformable nature of flexible sensors, it is difficult for traditional flexible sensor detection devices to fix the absolute position of the flexible sensor, resulting in the inability of the flexible sensor to be applied to scenarios with strict requirements for sensor position information. At the same time, the circuit of the flexible sensor itself is also easily affected by its deformation characteristics, resulting in signal distortion of the sensor and difficulty in controlling signal accuracy. Summary of the Invention

[0004] In order to solve the above technical problems, the present disclosure provides a multi-channel biochemical analysis detector and a control method therefor.

[0005] On the one hand, the present disclosure provides a multi-channel biochemical analysis detector, which is used to detect a biochemical sensing array. The biochemical sensing array includes a plurality of biochemical sensors arranged in an array and a signal interface connected to the biochemical sensors. The multi-channel biochemical analysis detector includes: a fixing unit, which is used to fix the signal interface of the biochemical sensing array.

[0006] The fixing unit includes: a socket, a fixing plane, an in-position detection module, a connection module, a driving module, and a control module.

[0007] The in-position detection module, the driving module, and the connection module are all electrically connected to the control module; the connection module is connected to the driving module.

[0008] The control module is configured to control the driving module to move in response to the in-position signal transmitted by the in-position detection module. The driving module drives the connection module to move until the connection module contacts the signal interface and fixes the signal interface on the fixing plane. Wherein, the in-position signal is triggered and generated by the in-position detection module when it detects that the signal interface is inserted into the socket.

[0009] On the other hand, the present disclosure also provides a control method for a multi-channel biochemical analysis detector. The multi-channel biochemical analysis detector is used to detect a biochemical sensing array, and the biochemical sensing array includes a plurality of biochemical sensors arranged in an array and a signal interface connected to the biochemical sensors; the multi-channel biochemical analysis detector includes a fixing unit for fixing the signal interface of the biochemical sensing array.

[0010] The fixing unit includes: a socket, a fixing plane, an in-position detection module, a connection module, a driving module, and a control module.

[0011] The in-position detection module, the driving module, and the connection module are all electrically connected to the control module; the connection module is fixed to the driving module.

[0012] The control method includes:

[0013] The control module responds to the in-position signal transmitted by the in-position detection module, controls the movement of the driving module, and the driving module drives the connection module to move until the connection module contacts the signal interface and fixes the signal interface on the fixing plane; wherein, the in-position signal is generated by the in-position detection module when it detects that the signal interface is inserted into the socket.

[0014] The technical solution provided by the present disclosure has the following advantages compared with the prior art:

[0015] The multi-channel biochemical analysis detector and the corresponding control method provided by the present disclosure are used to detect a biochemical sensing array, and include a fixing unit for fixing the signal interface of the biochemical sensing array. The fixing unit includes a socket, a fixing plane, an in-position detection module, a connection module, a driving module, and a control module. When the in-position detection module detects that the signal interface is inserted into the socket, it generates an in-position signal and transmits the in-position signal to the control module. The control module responds to the in-position signal, controls the driving module to drive the connection module to move until the connection module contacts the signal interface to form an electrical connection, and fixes the signal interface on the fixing plane. Based on this, the signal interface of the biochemical sensing array is fixed on the fixing plane in an electric control manner, so that the biochemical sensing array will not be displaced during the detection process, which is beneficial to improving the accuracy and stability of the signal; at the same time, the connection module is electrically connected to the signal interface, and the signal of the biochemical sensing array is also input into the multi-channel biochemical analysis detector. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings herein are incorporated into the specification and constitute a part of this specification, showing embodiments consistent with the present disclosure, and are used together with the specification to explain the principles of the present disclosure.

[0017] To more clearly illustrate the technical solutions in the embodiments of the present disclosure or the prior art, the following will briefly introduce the accompanying drawings required for the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0018] Figure 1 Structural schematic diagram of a biochemical sensing array provided by an embodiment of the present disclosure;

[0019] Figure 2 Structural schematic diagram of a multi-channel biochemical analysis detector provided by an embodiment of the present disclosure;

[0020] Figure 3 Structural schematic diagram of another multi-channel biochemical analysis detector provided by an embodiment of the present disclosure;

[0021] Figure 4 Structural schematic diagram of a fixing unit provided by an embodiment of the present disclosure;

[0022] Figure 5 Structural schematic diagram of yet another multi-channel biochemical analysis detector provided by an embodiment of the present disclosure;

[0023] Figure 6 Structural schematic diagram of a signal processing module provided by an embodiment of the present disclosure;

[0024] Figure 7 Structural schematic diagram of a constant current source circuit provided by an embodiment of the present disclosure;

[0025] Figure 8 Flow schematic diagram of a control method for a multi-channel biochemical analysis detector provided by an embodiment of the present disclosure;

[0026] Figure 9 Flow schematic diagram of another control method for a multi-channel biochemical analysis detector provided by an embodiment of the present disclosure;

[0027] Figure 10 Flow schematic diagram of yet another control method for a multi-channel biochemical analysis detector provided by an embodiment of the present disclosure. Detailed implementation manners

[0028] In order to more clearly understand the above-mentioned objects, features, and advantages of the present disclosure, the following will further describe the solutions of the present disclosure. It should be noted that, without conflict, the embodiments of the present disclosure and the features in the embodiments can be combined with each other.

[0029] In the following description, numerous specific details are set forth to provide a thorough understanding of the present disclosure, but the present disclosure may be practiced in other ways different from those described herein; obviously, the embodiments in the specification are only a part of the embodiments of the present disclosure, rather than all the embodiments.

[0030] The following will describe, in conjunction with the accompanying drawings, a multi-channel biochemical analysis detector and a control method provided by an embodiment of the present disclosure.

[0031] In some embodiments, such as Figure 1 shown, the biochemical sensing array 1 includes a plurality of biochemical sensors 11 arranged in an array and a signal interface 12 connected to the biochemical sensors.

[0032] Among them, the biochemical sensing array 1 belongs to a flexible sensor, which includes a plurality of biochemical sensors 11 and can specifically bind to multiple groups of biomolecules to be detected simultaneously, realizing batch detection and being beneficial to improving the detection efficiency.

[0033] The multi-channel biochemical analysis detector provided in this embodiment is used to measure the signal of the biochemical sensing array 1. The signal interface 12 of the biochemical sensing array 1 is inserted into the socket of the multi-channel biochemical analysis detector, and an electrical connection is established between the multi-channel biochemical analysis detector and the signal interface 12 to measure the signal of the biochemical sensing array 1, and finally output the target detection index. Exemplarily, the target detection index at least includes a resistance value.

[0034] Such as Figure 2-3 shown, the multi-channel biochemical analysis detector 2 includes a fixed unit housing mechanism, and other component units of the multi-channel biochemical analysis detector 2 are accommodated in the housing structure, such as a fixed unit, a control unit, a signal acquisition unit, a signal path selection unit, a signal processing unit, a communication unit, a display management unit, a power management unit, a storage unit, and an interaction unit.

[0035] The multi-channel biochemical analysis detector 2 includes a fixed unit, and the fixed unit is used to fix the signal interface 12 of the biochemical sensing array 1. Such as Figure 3 or Figure 4 shown, the fixed unit includes a socket 21, a fixed plane, an in-position detection module 22, a connection module 23, a driving module 24, and a control module 25; the in-position detection module 22, the driving module 24, and the connection module 23 are all electrically connected to the control module 25.

[0036] Among them, the socket 21 is provided on the housing mechanism and penetrates the housing mechanism in the thickness direction. The socket 21 is used to allow the signal interface 12 of the biochemical sensing array 1 to be inserted.

[0037] The in - place detection module 22 is used to detect that the signal interface 12 is inserted into the socket 21, generate an in - place signal, and transmit the in - place signal to the control module 25. Exemplarily, the in - place detection module 22 includes a photoelectric in - place sensor.

[0038] The fixed plane is used to place the signal interface 12 of the biochemical sensing array 1.

[0039] The connection module 23 serves both as a clamping mechanism for fixing the signal interface 12 and as a signal access terminal of the multi - channel biochemical analyzer 2, connecting the signal of the biochemical sensing array 1 to the multi - channel biochemical analyzer. The connection module 23 is connected to the driving module 24 and moves under the power drive of the driving module 24, contacts the signal interface 12 to form an electrical connection, so as to input the signal of the biochemical sensing array 1 into the multi - channel biochemical analyzer 2; at the same time, the signal interface 12 is pressed tightly on the fixed plane to fix the signal interface 12, so that the biochemical sensing array 1 will not be displaced during subsequent detection, which is beneficial to improving the accuracy and stability of the signal.

[0040] The control module 25 includes a microcontroller unit (MCU) on which a control program is stored. The control module 25 is used to respond to the in - place signal transmitted by the in - place detection module 22, determine that the signal interface 12 has been inserted into the socket 21 (or is located on the fixed plane), control the movement of the driving module 24, and the driving module 24 drives the connection module 23 to move until the connection module 23 contacts the signal interface 12 to form an electrical connection and fixes the signal interface 12 on the fixed plane. With such a setting, the signal interface 12 of the biochemical sensing array 1 is fixed in an electric - control manner.

[0041] Exemplarily, as Figure 2 shown, the housing mechanism of the multi - channel biochemical analyzer 2 is a hexahedron, and a display screen 31 and keys are arranged on the upper cover plate 41; the socket 21 is located on the side frame, the side frame is connected to the upper cover plate 41, and the side frame is connected to the bottom shell 42. Figure 3 For Figure 2 the multi - channel biochemical analyzer 2 with the cover plate 41 removed as shown, the fixing unit inside the housing mechanism is exposed. The fixing unit includes a socket 21, an in - place detection module 22, a connection module 23, a driving module, a fixed plane (not shown in the figure) and a control module (not shown in the figure). The fixed platform is parallel to the plane where the upper cover plate 41 is located.

[0042] In some embodiments, the fixed plane is fixedly connected to the housing mechanism.

[0043] In some embodiments, the fixed platform and the housing mechanism are set as an integrated structure, omitting the installation step of the fixed platform.

[0044] The multi-channel biochemical analysis detector 2 provided by the embodiments of the present disclosure includes a fixing unit for fixing the signal interface of the biochemical sensing array. The fixing unit includes a socket 21, a fixing plane, an in-place detection module 22, a connection module 23, a driving module 24, and a control module 25. When the in-place detection module 22 detects that the signal interface 12 is inserted into the socket 21, it generates an in-place signal and transmits the in-place signal to the control module 25. In response to the in-place signal, the control module 25 controls the driving module 24 to drive the connection module 23 to move until the connection module 23 contacts the signal interface 12 to form an electrical connection, and fixes the signal interface 12 on the fixing plane. Based on this, the connection module 23 is used to fix the signal interface 12 of the biochemical sensing array on the fixing plane, so that the biochemical sensing array 1 will not be displaced during the detection process, which is beneficial to improving the accuracy and stability of the signal; at the same time, the connection module 23 is electrically connected to the signal interface 12, and it also realizes the input of the signal of the biochemical sensing array 1 into the multi-channel biochemical analysis detector 2.

[0045] In some embodiments, the driving module includes a driving device and a transmission component. The connection module is located on the side of the transmission component close to the signal interface; the driving device operates to drive the transmission component to move, and the transmission component drives the connection module to move in the direction close to the signal interface until the connection module contacts the signal interface and fixes the signal interface on the fixing plane.

[0046] Among them, the transmission component is connected to the driving device and the connection module. The control module controls the driving device to output a driving force. The transmission component moves under the action of the driving force, thereby driving the connection module to move, so that the connection module moves in the direction close to the signal interface until the connection module contacts the signal interface to form an electrical connection, and fixes the signal interface on the fixing plane to prevent the signal interface from being displaced.

[0047] In some embodiments, as Figure 3 shown, the driving device includes a servo motor 241, the transmission component includes a gear 242 and a rack 243. The servo motor 241 is coaxial with the gear 242, the gear 242 meshes with the rack 243, and the connection module 23 is located on the side of the rack 243 close to the signal interface (or the fixing plane); among them, the servo motor 241 rotates a preset angle along its own axis, drives the gear 242 to rotate, and the gear 242 drives the rack 243 to move in the first direction until the connection module 23 contacts the signal interface and the signal interface is fixed on the fixing plane; the first direction is perpendicular to the axis of the servo motor 241.

[0048] In this embodiment, when a biochemical sensing array is inserted into the socket 21, the in-position detection module 22 sends an in-position signal to the control module. After the control module determines through the program that the biochemical sensing array is in position, it drives the servo 241 to rotate a preset angle along its own axis, thereby driving the transmission gear 242 to rotate. Since the gear 242 meshes with the rack 243, the rotation of the gear 242 drives the rack 243 to move linearly. The connection module 23 is fixed to one end of the rack 243 close to the signal interface (or fixed plane). The movement of the rack 243 drives the connection module 23 to contact the signal interface of the biochemical sensing array, forming an electrical path, and at the same time fixing the signal interface on the fixed plane to prevent the signal interface from being displaced.

[0049] In some embodiments, as Figure 4 shown, the fixing unit 20 further includes a first communication interface 26. The first communication interface 26 is used to connect the control module and the driving device. The control module transmits a Pulse Width Modulation (PWM) control signal to the driving device through the first communication interface 26, thereby controlling the operation of the driving device.

[0050] Exemplarily, the driving device includes a servo. The control module transmits a PWM control signal to the servo through the first communication interface 26, thereby controlling the servo to rotate a preset angle.

[0051] In some embodiments, as Figure 4 shown, the fixing unit 20 further includes an independent power management module 27. The power management module 27 is used to control the voltage, current and power within the fixing unit 20, and to control the conduction and cut-off of the internal power supply path of the fixing unit 20.

[0052] In some embodiments, as Figure 5 shown, the multi-channel biochemical analysis detector further includes: a signal channel selection unit, a signal acquisition unit and a control unit. The control module, the signal channel selection unit and the signal acquisition unit of the fixing unit are all electrically connected to the control unit. The connection module is electrically connected to the signal channel selection unit, and the signal channel selection unit is electrically connected to the signal acquisition unit; the control unit is used to control the signal channel selection unit to select the signal access channel of the biochemical sensor based on the fixing of the signal interface of the biochemical sensing array by the fixing unit, and to control the signal acquisition unit to collect the target signal of the signal access channel selected by the signal channel selection unit, and to perform data processing on the collected target signal to obtain the target detection index.

[0053] Among them, as Figure 1As shown, the signal interface 12 includes a first signal interface 121 and multiple second signal interfaces 122. The first signal interface 121 is electrically connected to the common terminal 12 of the biochemical sensor 11, and the second signal interfaces 122 are electrically connected to the other ends of the biochemical sensor 11 in a one-to-one correspondence. One signal access channel includes the first signal interface 121, one second signal interface 122, and one biochemical sensor 11 correspondingly connected between the first signal interface 121 and the second signal interface 122. Exemplarily, as Figure 1 shown, the biochemical sensing array 1 includes 25 biochemical sensors 11, 1 first signal interface 121, and 25 second signal interfaces 122. The biochemical sensing array includes 25 signal access channels.

[0054] Among them, the connection module is electrically connected to the signal channel selection unit, and inputs the signals of the biochemical sensing array into the signal channel selection unit.

[0055] The signal channel selection unit has a gating function. The signal channel selection unit selects multiple signal access channels on the biochemical sensing array, and each time it selects one of the signal access channels to conduct with the signal acquisition unit. The signal acquisition unit samples and converts the target signal of the conducted signal access channel, and then the control unit processes the data of the target signal to obtain the target detection index corresponding to the group of signal access channels; then the signal channel selection unit selects another signal access channel to conduct with the signal acquisition unit, and the signal acquisition unit and the control unit repeat the above steps; and so on, until the target detection values corresponding to all the signal access channels on the biochemical sensing array are obtained.

[0056] The control unit is the core component of the multi-channel biochemical analyzer and has a data processing function. The control unit controls the working logic and parameter configuration of each component unit of the multi-channel biochemical analyzer through various communication protocols to implement the logical execution of the established tasks of the multi-channel biochemical analyzer. The control unit includes a single-chip microcomputer. Exemplarily, the control unit includes an STM32F407ZET6 single-chip microcomputer.

[0057] The signal channel selection unit includes all electronic devices with a gating function known to those skilled in the art, such as a single-pole multi-throw switch, a switch chip, or a selector, which is not limited here. Exemplarily, the signal channel selection unit includes a multiplexer chip CD4051.

[0058] The signal acquisition unit includes an analog-to-digital converter (ADC). In some embodiments, the analog-to-digital converter inside the control unit is used as the signal acquisition unit.

[0059] The multi-channel biochemical analysis detector provided in this embodiment uses a connection module to fix the signal interface of the biochemical sensor array on a fixed plane, so that the biochemical sensor array will not be displaced during the detection process, which is beneficial to improving the accuracy and stability of the signal; at the same time, the connection module inputs the signal interface into the multi-channel biochemical analysis detector, realizing the measurement and reading of the signals of multiple biochemical sensors on the biochemical sensor array.

[0060] In some embodiments, as Figure 5 shown, the multi-channel biochemical analysis detector further includes at least one of a display management unit, a storage unit, a power management unit, an interaction unit, and a communication unit; the display management unit, the storage unit, the power management unit, the interaction unit, and the communication unit are all electrically connected to the control unit.

[0061] Among them, the display management unit includes a display driving circuit for driving a display screen to display target detection indicators and / or configuration information of the multi-channel biochemical analysis detector on the display screen. Exemplarily, the display management unit includes a thin film transistor driving circuit, and the display screen is a liquid crystal display screen.

[0062] The storage unit is used to save target signals and / or target detection indicators. The present disclosure does not limit the type of the storage unit, and all electronic devices with storage functions known to those skilled in the art can be used, such as flash memories. Exemplarily, the storage unit includes a flash memory chip W25Q128.

[0063] The power management unit is used to control the voltage, current, and power of the multi-channel biochemical analysis detector. The power management unit controls the voltage, current, and power of the input power supply of the entire multi-channel biochemical analysis detector. Exemplarily, the power management unit includes a voltage regulator chip TPS7333.

[0064] The interaction unit is used to provide an operation interface for the user and, in response to user operations, set parameters of the multi-channel biochemical analysis detector. Exemplarily, as Figure 2 shown, the multi-channel biochemical analysis detector includes a display screen 31 and a key 51, and the user configures relevant parameters of the multi-channel biochemical analysis detector through the key and the display screen.

[0065] The communication unit is used to transmit target detection indicators to a remote server, receive control instructions sent by the remote server, and forward the control instructions to the control unit, and the control unit completes the arithmetic processing corresponding to the control instructions. The communication unit includes a wireless communication module and / or a wired communication module. Exemplarily, the wireless communication module includes an ESP-01F wireless communication module.

[0066] Exemplarily, as Figure 5As shown in the figure, the control unit communicates with the control module of the fixed unit through the UART communication protocol, communicates with the signal channel selection unit through the GPIO communication protocol, communicates with the power management module through the GPIO communication protocol, communicates with the communication unit through the UART communication protocol, communicates with the display management unit through the SPI communication protocol, communicates with the interaction module through the GPIO communication protocol, and communicates with the storage module through the SPI communication protocol. The signal acquisition unit is implemented by using the internal ADC of the control unit. The control unit controls the working logic and parameter configuration of each unit through various communication protocols, and realizes the logical execution of the established tasks of the multi-channel biochemical analyzer.

[0067] The multi-channel biochemical analyzer provided by the embodiments of the present disclosure not only has the functions of processing, collecting, and calculating sensor signals, but also has functions such as real-time display, communication, local storage, and human-computer interaction, making the multi-channel biochemical analyzer more functional and more intelligent to use.

[0068] In some embodiments, as Figure 3 shown, the connection module 23 includes: a spring pin 231; the spring pin 231 includes a first spring pin and a plurality of second spring pins, the first spring pin and the second spring pins are arranged in sequence along the extension direction of the socket 21, the first spring pin corresponds to the first signal interface, and the second spring pins correspond to the second signal interfaces one by one.

[0069] Wherein, the spring pin includes a spring and a conductive probe fixedly connected, and the conductive probe is located on the side of the spring close to the signal interface. Exemplarily, the conductive probe includes a metal probe.

[0070] With such a setting, driven by the driving module, the conductive probe of the spring pin contacts the signal interface to form an electrical path, and using the rebound force generated by the spring compression, the spring pin presses the signal interface against the fixed plane, thereby realizing the fixation of the signal interface.

[0071] In some embodiments, as Figure 3 shown, the fixed unit further includes a spring pin limiting plate 29.

[0072] Wherein, the spring pin limiting plate 29 is used to limit the position of the spring pin 231, prevent the spring pin 231 from moving too far towards the signal interface, and avoid damaging the signal interface due to excessive pressure of the spring pin 231 pressing the signal interface.

[0073] In some embodiments, as Figure 5As shown, the multi-channel biochemical analysis detector further includes: a signal processing unit, a connection module, and a signal channel selection unit. Both the connection module and the signal channel selection unit are electrically connected to the signal processing unit. The signal processing unit is configured to amplify and / or filter the signal transmitted by the connection module and transmit the processed signal to the signal channel selection unit.

[0074] Among them, the signal processing unit is electrically connected to the signal interface through the connection module. The signal of the biochemical sensing array is input to the signal processing unit. After being amplified and / or filtered by the signal processing unit, the processed signal is transmitted to the signal channel gating unit.

[0075] In some embodiments, the signal of the biochemical sensor includes a voltage signal. The signal processing unit includes at least one of a differential amplifier circuit, a voltage follower circuit, and a filter circuit. Among them, the differential amplifier circuit is configured to amplify the voltage signal by a preset multiple; the voltage follower circuit is configured to enhance the load-carrying capacity of the voltage signal; the filter circuit is configured to filter out the clutter of the voltage signal and improve the signal stability.

[0076] In some embodiments, as Figure 6 shown, the differential amplifier circuit includes: a first operational amplifier U7A, a first resistor R16, a second resistor R12, a third resistor R19, and a fourth resistor R28. The first operational amplifier U7A includes a first input terminal, a second input terminal, a first output terminal, a first power supply pin, and a second power supply pin. The first input terminal is electrically connected to the first signal interface. The first resistor R16 is connected in series between the first input terminal and the first signal interface. The second resistor R12 is connected in series between the first input terminal and the first output terminal. The second input terminal is electrically connected to the second signal interface. The third resistor R19 is connected in series between the second input terminal and the second signal interface. The fourth resistor R28 is connected in series between the second input terminal and the second power supply pin. The ratio of the resistance value of the second resistor R12 to the first resistor R16 and the ratio of the resistance value of the fourth resistor R28 to the third resistor R19 are both equal to the preset multiple. The preset multiple is equal to the amplification multiple, that is, the amplification multiple of the voltage signal is equal to the ratio of the resistance value of the second resistor R12 to the first resistor R16, or the amplification multiple of the voltage signal is equal to the ratio of the resistance value of the fourth resistor R28 to the third resistor R19.

[0077] Among them, the first input terminal is electrically connected to the first signal interface through a first spring pin, and the second input terminal is electrically connected to the second signal interface through a second spring pin.

[0078] Exemplarily, as Figure 6As shown, the first operational amplifier U7A includes an LM358M / TR operational amplifier, the pin corresponding to number 1 is the first output terminal, the pin corresponding to number 2 is the first input terminal, the pin corresponding to number 3 is the second input terminal, the pin corresponding to number 4 is the second power supply pin, the first power supply pin is connected to a 5V high level, the second power supply pin is connected to a -5V low level, V1_2 is electrically connected to the first signal interface, V1_1 and V1_2 are differential voltage input terminals, wherein V1_2 is electrically connected to the first signal interface through a first spring pin, and V1_1 is electrically connected to the second signal interface through a second spring pin; the resistance of the second resistor R12 is 499K, the resistance of the first resistor R16 is 2K, and the resistance ratio of the two is approximately equal to 250, the resistance of the fourth resistor R28 is 499K, and the resistance of the third resistor R19 is 2K, and the resistance ratio of the two is also equal to 250. The differential amplifier circuit amplifies the voltage signal of the biochemical sensor by 250 times.

[0079] It should be noted that Figure 6 The differential amplifier circuit is only exemplarily shown to amplify the voltage signal by 250 times, which does not constitute a limitation on the multi-channel biochemical analysis detector provided by the embodiment of the present disclosure. In other embodiments, the amplification factor can be flexibly set according to needs, which is not limited here.

[0080] In some embodiments, Figure 6 As shown, the voltage follower circuit includes a second operational amplifier U7B; the second operational amplifier U7B includes a third input terminal, a fourth input terminal and a second output terminal, the third input terminal is electrically connected to the first output terminal, and the fourth input terminal is electrically connected to the second output terminal.

[0081] The voltage follower circuit is located after the differential amplifier circuit.

[0082] For example, Figure 6 As shown, the second operational amplifier U7B includes an LM358M / TR operational amplifier, number 5 is the third input terminal, number 6 is the fourth input terminal, and number 7 is the second output terminal.

[0083] In some embodiments, Figure 6 As shown, the filtering circuit includes a fifth resistor R17 and a first capacitor C18; the input end of the fifth resistor R17 is electrically connected to the second output end, the output end of the fifth resistor R17 is electrically connected to the input end of the first capacitor C18, the output end of the first capacitor C18 is grounded, and the output end of the fifth resistor R17 is also electrically connected to the signal acquisition unit.

[0084] For example, Figure 6 As shown, the AD1 terminal is used to electrically connect the signal acquisition unit.

[0085] In some embodiments, the multi-channel biochemical analysis detector further includes: a constant current source circuit, which is used to form a differential voltage signal between the first signal interface and the second signal interface.

[0086] Among them, the constant current source circuit is electrically connected to the signal interface through a connection module, so as to supply power to the signal access channel, make the current of the signal access channel constant, and form a differential voltage between the first signal interface and the second signal interface. The two differential voltages corresponding to each group of signal access channels are input into a differential amplifier circuit, which is converted into a single-ended voltage signal by the differential amplifier circuit, and then the voltage signal is collected by a signal acquisition unit, and the control unit calculates the resistance value of each signal access channel according to Ohm's law.

[0087] Exemplarily, in combination with Figure 1 , there are 25 biochemical sensors on the biochemical sensing array, that is, 25 groups of signal access channels. A 1 mA constant current source is used to form a loop with 25 groups of signal access channels through a connection module (or spring pins). At this time, a pair of differential voltage signals are formed between the first signal interface and the second signal interface of each group of signal access channels.

[0088] In some embodiments, as Figure 7 shown, the constant current source circuit includes a power supply chip U9, a sixth resistor R13 and a ground terminal GND; among them, the first terminal of the power supply chip U9 is electrically connected to the input terminal of the sixth resistor R13, and the second terminal of the power supply chip U9 and the second spring pin are both electrically connected to the output terminal of the sixth resistor R13, and the first spring pin is electrically connected to the ground terminal GND.

[0089] Exemplarily, as Figure 7 shown, the power supply chip U9 is an LM234DT chip, the input terminal of the sixth resistor R13 is electrically connected to the adjustment pin (ADJ) of the LM234DT chip, and the output terminal of the sixth resistor R13 is electrically connected to the output pin (V-) of the power supply chip U9; the connection point between the output terminal of the sixth resistor R13 and the output pin (V-) of the power supply chip U9 is electrically connected to the second spring pin, and the first spring pin is electrically connected to the ground terminal, so as to realize connecting the constant current source circuit to each group of signal access channels; among them, the PORT1_1 port is electrically connected to the second signal interface through the second spring pin, and the COM port is electrically connected to the first signal interface through the first spring pin.

[0090] In some embodiments, as Figure 7 shown, a resistor R14 is connected in series between the output pin (V-) of the power supply chip U9 and the PORT1_1 port; a resistor R21 and a resistor R20 are connected in series between the ground terminal and the COM port; a resistor R15 and a second capacitor C14 are connected in series from the PORT1_1 port to the ground, and a resistor R27 and a third capacitor C19 are connected in series from the COM port to the ground.

[0091] In some embodiments, the signal channel selection unit includes at least one selector, and the selector is electrically connected to the signal acquisition unit; the selector is used to select any one of all the signal access channels to be connected to the signal acquisition unit.

[0092] Wherein, one signal access channel includes a first signal interface, a second signal interface, and a biochemical sensor correspondingly connected between the first signal interface and the second signal interface; the input end of the selector is electrically connected to the spring pin, that is, the selector is electrically connected to the signal interface of the biochemical sensor array, realizing the electrical connection between the signal access channel and the selector.

[0093] The selector has a multi-channel gating function. Each time the selector selects one of the signal access channels to be connected to the signal acquisition unit, and the signal acquisition unit collects the target signal of this group of signal channels. One signal access channel is selected and one target signal is sampled at a time until all the target signals of the signal access channels on the biochemical sensor array are collected, completing a complete sampling cycle.

[0094] In some embodiments, the selector includes N first-level selectors and a second-level selector. The first-level selectors are electrically connected to the second-level selector, and the second-level selector is electrically connected to the signal acquisition unit; the first-level selectors are used to select any one of the corresponding multiple signal access channels to be connected to the second-level selector; the second-level selector is used to select one of the N first-level selectors to be connected to the signal acquisition unit; the second-level selector includes an M-to-1 selector; wherein, M and N are positive integers, N is greater than or equal to 2, and M is greater than or equal to N.

[0095] In this embodiment, the signal access channels are pre-divided into N groups. The signal access channels within each group are electrically connected to the corresponding first-level connector through spring pins. Each first-level selector selects one of the multiple signal access channels in the corresponding group to conduct with the second-level selector. The second-level selector selects one of the N first-level selectors to conduct with the signal acquisition unit, conducts any one of all the signal access channels with the signal acquisition unit, and the signal acquisition unit collects the target signal of this signal access channel, so as to realize the selection / sampling of any one of all the signal access channels. Only one channel is selected (sampled) at a time, and the selection (sampling) step is repeated until all the signal access channels are selected (sampled).

[0096] Exemplarily, the biochemical sensing array includes 25 signal access channels, and the path selection unit includes four eight-to-one first-level selectors and one four-to-one second-level selector; among them, the 1st to 8th signal access channels enter the 1st first-level selector, the 9th to 16th signal access channels enter the 2nd first-level selector, the 17th to 24th signal access channels enter the 3rd first-level selector, and the 25th signal access channel enters the 4th first-level selector. The second-level selector selects the 1st to 4th first-level selectors, so as to realize the selection of any one of the 25 signal access channels, and then the signal acquisition unit acquires the target signal of this signal access channel. The selection / sampling is continuously repeated 25 times to complete a complete sampling cycle.

[0097] In some embodiments, the housing mechanism of the multi-channel biochemical analyzer is made by using the metamaterial 3D printing process, which has the characteristics of high temperature resistance, high pressure resistance, good airtightness and light weight, and can be widely used in harsh environments such as aerospace, deep sea and polar regions, thus broadening the usage scenarios of the multi-channel biochemical analyzer.

[0098] On the basis of the above embodiments, the embodiments of the present disclosure also provide a control method for any one of the above multi-channel biochemical analyzers, which has corresponding beneficial effects. The same parts can be understood with reference to the above, and will not be repeated hereinafter.

[0099] In some embodiments, as Figure 1 shown, the biochemical sensing array includes a plurality of biochemical sensors 11 arranged in an array and signal interfaces 12 connected to the biochemical sensors; as Figure 3-4 shown, the multi-channel biochemical analyzer 2 includes a fixing unit, and the fixing unit is used to fix the signal interface 12 of the biochemical sensing array; the fixing unit includes: a socket 21, a fixing plane, an in-place detection module 22, a connection module 23, a driving module 24 and a control module 25; the in-place detection module 22, the driving module 24 and the connection module 23 are all electrically connected to the control module 25; the connection module 23 is fixed to the driving module 24.

[0100] Among them, the socket 21 is arranged on the housing mechanism and penetrates the housing mechanism in the thickness direction. The socket 21 is used to allow the signal interface 12 of the biochemical sensing array 1 to be inserted. The in-place detection module 22 is used to detect that the signal interface 12 is inserted into the socket 21, generate an in-place signal, and transmit the in-place signal to the control module 25; exemplarily, the in-place detection module 22 includes a photoelectric in-place sensor. The fixing plane is used to place the signal interface 12 of the biochemical sensing array 1. The control module 25 includes a microcontroller unit (MCU), on which a control program is stored.

[0101] The control method of the multi-channel biochemical analyzer includes the following steps:

[0102] S100. The control module responds to the in-place signal transmitted by the in-place detection module, controls the movement of the driving module, and the driving module drives the connection module to move until the connection module contacts the signal interface and fixes the signal interface on the fixed plane.

[0103] Among them, the in-place signal is triggered and generated by the in-place detection module when it detects that the signal interface is inserted into the socket.

[0104] In this embodiment, the control module 25 responds to the in-place signal transmitted by the in-place detection module 22, determines that the signal interface 12 has been inserted into the socket 21 (or is already on the fixed plane), controls the movement of the driving module 24, and the driving module 24 drives the connection module 23 to move until the connection module 23 contacts the signal interface 12 to form an electrical connection, and fixes the signal interface 12 on the fixed plane. With such a setting, the signal interface 12 of the biochemical sensing array 1 is fixed in an electric control manner.

[0105] The connection module 23 serves both as a clamping mechanism for fixing the signal interface 12 and as a signal access end of the multi-channel biochemical analyzer 2, and accesses the signal of the biochemical sensing array 1 to the multi-channel biochemical analyzer 2. The connection module 23 is connected to the driving module 24 and moves under the power drive of the driving module 24, contacts the signal interface 12 to form an electrical connection, realizes the input of the signal of the biochemical sensing array 1 to the multi-channel biochemical analyzer 2; at the same time, presses the signal interface 12 tightly on the fixed plane to realize the fixation of the signal interface 12, so that the biochemical sensing array 1 will not be displaced during subsequent detection, which is beneficial to improving the accuracy and stability of the signal.

[0106] In some embodiments, the driving module includes a driving device and a transmission component, and the connection module is located on the side of the transmission component close to the signal interface. The control method includes the following steps:

[0107] The control module responds to the in-place signal transmitted by the in-place detection module, controls the driving device to operate to drive the transmission component to move, and the transmission component drives the connection module to move in the direction close to the signal interface until the connection module contacts the signal interface and fixes the signal interface on the fixed plane.

[0108] Among them, the transmission component is connected to the driving device and the connection module. The control module controls the driving device to output a driving force, and the transmission component moves under the action of the driving force, thereby driving the connection module to move, so that the connection module moves in the direction close to the signal interface until the connection module contacts the signal interface to form an electrical connection and fixes the signal interface on the fixed plane to prevent the signal interface from being displaced.

[0109] In some embodiments, such as Figure 3As shown in the figure, the driving device includes a servo 241, the transmission assembly includes a gear 242 and a rack 243. The servo 241 is coaxial with the gear 242, the gear 242 meshes with the rack 243, and the connection module 23 is located on one side of the rack 243 close to the signal interface (or the fixed plane); the control method includes the following steps:

[0110] The control module responds to the in-place signal transmitted by the in-place detection module, controls the servo to rotate a preset angle along its own axis, drives the gear to rotate, and the gear drives the rack to move in the first direction until the connection module contacts the signal interface and the signal interface is fixed on the fixed plane;

[0111] Wherein, the first direction is perpendicular to the axis of the servo.

[0112] In this embodiment, when the signal interface of the biochemical sensing array is inserted into the socket 21, the in-place detection module 22 sends an in-place signal to the control module. After the control module determines through the program that the biochemical sensing array is in place, it drives the servo 241 to rotate a preset angle along its own axis, thereby driving the transmission gear 242 to rotate. Since the gear 242 meshes with the rack 243, the rotation of the gear 242 drives the rack 243 to move linearly. The connection module 23 is fixed at one end of the rack 243 close to the signal interface (or the fixed plane). The movement of the rack 243 drives the connection module 23 to contact the signal interface of the biochemical sensing array, forming an electrical path, and at the same time fixing the signal interface on the fixed plane to prevent the signal interface from being displaced.

[0113] In some embodiments, as Figure 5 shown, the multi-channel biochemical analysis detector further includes: a signal channel selection unit, a signal acquisition unit, and a control unit. The fixing unit, the signal channel selection unit, and the signal acquisition unit are all electrically connected to the control unit. The connection module is electrically connected to the signal channel selection unit, and the signal channel selection unit is electrically connected to the signal acquisition unit;

[0114] The control method further includes the following steps:

[0115] S210. The control unit, based on the fixing unit fixing the signal interface of the biochemical sensing array, controls the signal channel selection unit to select the signal access channels of the biochemical sensors.

[0116] Wherein, as Figure 1 shown, the signal interface 12 includes a first signal interface 121 and a plurality of second signal interfaces 122. The first signal interface 121 is electrically connected to the common terminal 12 of the biochemical sensor 11, and the second signal interfaces 122 are electrically connected to the other ends of the biochemical sensors 11 in one-to-one correspondence. One signal access channel includes the first signal interface 121, one second signal interface 122, and one biochemical sensor 11 correspondingly connected between the first signal interface 121 and the second signal interface 122. Exemplarily, asFigure 1 As shown, the biochemical sensing array 1 includes 25 biochemical sensors 11, a first signal interface 121, and 25 second signal interfaces 122. The biochemical sensing array includes 25 signal access channels.

[0117] Among them, the connection module is electrically connected to the signal channel selection unit, and inputs the signals of the biochemical sensing array to the signal channel selection unit.

[0118] S220. The control unit controls the signal acquisition unit to collect the target signals of the biochemical sensors in the access channels.

[0119] S230. The control unit processes the collected target signals to obtain the target detection indicators.

[0120] In this embodiment, the signal channel selection unit has a gating function. The signal channel selection unit selects from multiple signal access channels on the biochemical sensing array, and each time it selects one of the signal access channels to conduct with the signal acquisition unit. The signal acquisition unit samples and converts the target signals of the conducted signal access channel, and then the control unit processes the target signals to obtain the target detection indicators corresponding to this group of signal access channels; then the signal channel selection unit selects another signal access channel to conduct with the signal acquisition unit, and the signal acquisition unit and the control unit repeat the above steps; and so on, until the target detection values corresponding to all signal access channels on the biochemical sensing array are obtained.

[0121] In some embodiments, the control method further includes the following steps:

[0122] The control unit generates a display instruction and a storage instruction;

[0123] Among them, the display instruction is used to control the display management module to drive the display screen to display the target detection indicators and / or the configuration information of the multi-channel biochemical analyzer; the storage instruction is used to control the storage unit to save the target signals and / or the target detection indicators.

[0124] In this embodiment, after completing the detection of all signal access channels on the biochemical sensing array, the control unit controls the display screen to display the detection results, and controls the storage unit to store the detection results. The detection results include the target detection indicators and the target signals (such as voltage signals). In addition, it can also control the display screen to display the configuration information of the multi-channel biochemical analyzer.

[0125] In some embodiments, after "generating the display instruction and the storage instruction", the control method further includes the following steps:

[0126] The control unit sends a release instruction to the fixing unit;

[0127] Among them, the release instruction is used to control the fixing unit to release the signal interface of the biochemical sensing array. After detecting all the signal access channels on the biochemical sensing array, release the signal interface, remove the detected biochemical sensing array, and take another biochemical sensing array to be detected for detection.

[0128] Exemplarily, as Figure 10 shown, the control method includes the following steps:

[0129] S310. Initialize the peripherals.

[0130] In this step, initialize the hardware peripheral driver.

[0131] S320. Determine whether the biochemical sensing array is in place.

[0132] In this step, based on the in-place signal transmitted by the optoelectronic in-place sensor, determine whether the biochemical sensing array is in place. If it is in place, that is, the determination result is "yes", then execute S303; if it is not in place, that is, the determination result is no, return and execute this step again.

[0133] S330. Clamp the signal interface of the biochemical sensing array.

[0134] In this step, control the servo motor to rotate a preset angle to drive the gear to rotate. Since the gear meshes with the rack, the rotation of the gear drives the rack to move linearly. The spring pin is fixed at one end of the rack close to the signal interface (or fixed plane), and the movement of the rack drives the spring pin to contact the signal interface of the biochemical sensing array to form an electrical connection, and at the same time clamp the sensor signal interface.

[0135] S340. Select the signal access channel.

[0136] In this step, select the signal access channel by the signal access channel selection signal, and each time select one signal access channel to be electrically connected to the backend circuit.

[0137] S350. Signal amplification processing.

[0138] Among them, the signal processing unit includes a differential amplifier circuit, and the differential amplifier circuit is used to amplify the signal of the selected signal access channel. The signal processing circuit also includes a voltage follower circuit and / or a filter circuit.

[0139] S360. Signal sampling.

[0140] In this step, the signal acquisition unit samples and converts the target signal. Exemplarily, the signal acquisition unit includes an analog-to-digital converter, and the analog-to-digital converter is used to convert the analog signal into a digital signal to obtain a voltage value.

[0141] S370. Process and calculate the sampled data.

[0142] In this step, the control unit calculates the average value of the voltage values transmitted by the signal acquisition unit, and then substitutes the average value into Ohm's law to obtain the resistance value.

[0143] S380. Detection result display and storage.

[0144] In this step, the detection result is displayed on the display screen, and at the same time, the detection result is saved in the storage unit.

[0145] S390. Loosen the signal interface of the biochemical sensing array.

[0146] Up to this step, the control fixing unit loosens the signal interface, completes the detection of a biochemical sensing array, returns to execute S320, the user pulls out the detected biochemical sensing array, and inserts a new biochemical sensing array for detection.

[0147] It should be noted that in this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0148] The above are only specific embodiments of the present disclosure, enabling those skilled in the art to understand or implement the present disclosure. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present disclosure. Therefore, the present disclosure will not be limited to these embodiments described herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.

Claims

1. A multi-channel biochemical analysis detector, characterized in that: The multi-channel biochemical analysis detector is used to detect a biochemical sensor array, wherein the biochemical sensor array includes a plurality of biochemical sensors arranged in an array and a signal interface connected to the biochemical sensors; The multi-channel biochemical analysis detector comprises: a fixing unit, the fixing unit is used to fix the signal interface of the biochemical sensor array; The fixing unit comprises: a socket, a fixing plane, an in-place detection module, a connection module, a driving module and a control module; The in-position detection module, the driving module and the connecting module are all electrically connected to the control module; the connecting module is connected to the driving module; The control module is used to control the movement of the driving module in response to the in-place signal transmitted by the in-place detection module, and the driving module drives the connection module to move until the connection module contacts the signal interface to form an electrical connection and fixes the signal interface on the fixed plane; wherein the in-place signal is triggered and generated by the in-place detection module when it detects that the signal interface is inserted into the socket.

2. The multi-channel biochemical analysis detector according to claim 1, characterized in that: The driving module includes: a driving device and a transmission component; the connecting module is located on a side of the transmission component close to the signal interface; The driving device operates to drive the transmission component to move, and the transmission component drives the connection module to move toward the direction close to the signal interface until the connection module contacts the signal interface and fixes the signal interface on the fixed plane.

3. The multi-channel biochemical analysis detector according to claim 2, characterized in that: The driving device includes a steering gear, the transmission assembly includes a gear and a rack, the steering gear is coaxial with the gear, the gear is meshed with the rack, and the connection module is located on a side of the rack close to the signal interface; The servo rotates along its own axis by a preset angle to drive the gear to rotate, and the gear drives the rack to move along a first direction until the connection module contacts the signal interface and the signal interface is fixed on the fixed plane; the first direction is perpendicular to the axial direction of the servo.

4. The multi-channel biochemical analysis detector according to claim 1, characterized in that: Also includes: A signal channel selection unit, a signal acquisition unit and a control unit, wherein the control module, the signal channel selection unit and the signal acquisition unit are all electrically connected to the control unit, the connection module is electrically connected to the signal channel selection unit, and the signal channel selection unit is electrically connected to the signal acquisition unit; The control unit is used to control the signal channel selection unit to select the signal access channel of the biochemical sensor based on the signal interface of the biochemical sensor array fixed by the fixing unit, and control the signal acquisition unit to collect the target signal of the signal access channel selected by the signal channel selection unit, and perform data processing on the collected target signal to obtain the target detection index; Among them, the signal interface includes a first signal interface and multiple second signal interfaces, the first signal interface is electrically connected to the common end of the biochemical sensor, the second signal interface is electrically connected to the other end of the biochemical sensor in a one-to-one correspondence, and a signal access channel includes the first signal interface, one second signal interface and one biochemical sensor correspondingly connected between the first signal interface and the second signal interface.

5. The multi-channel biochemical analysis detector according to claim 4, characterized in that: The connection module comprises: a spring pin header; The spring pin header includes a first spring pin and a plurality of second spring pins, wherein the first spring pin corresponds to the first signal interface, and the second spring pins correspond to the second signal interface one by one.

6. The multi-channel biochemical analysis detector according to claim 4, characterized in that: Also includes: A signal processing unit is electrically connected to the connection module and the signal channel selection unit, and is used to amplify and / or filter the signal transmitted by the connection module, and transmit the processed signal to the signal channel selection unit.

7. The multi-channel biochemical analysis detector according to claim 6, characterized in that: The signal includes a voltage signal, and the signal processing unit includes: at least one of a differential amplifier circuit, a voltage follower circuit, and a filter circuit; The differential amplifier circuit is used to amplify the voltage signal by a preset multiple; The voltage follower circuit is used to improve the load carrying capacity of the voltage signal; The filter circuit is used to filter the noise of the voltage signal.

8. The multi-channel biochemical analysis detector according to claim 7, characterized in that: The differential amplifier circuit includes: a first operational amplifier, a first resistor, a second resistor, a third resistor and a fourth resistor; the first operational amplifier includes a first input terminal, a second input terminal, a first output terminal, a first power supply pin and a second power supply pin, the first input terminal is electrically connected to the first signal interface, the first resistor is connected in series between the first input terminal and the first signal interface, and the second resistor is connected in series between the first input terminal and the first output terminal; the second input terminal is electrically connected to the second signal interface, the third resistor is connected in series between the second input terminal and the second signal interface, and the fourth resistor is connected in series between the second input terminal and the second power supply pin; the resistance ratio of the second resistor to the first resistor and the resistance ratio of the fourth resistor to the third resistor are both equal to the preset multiple; The voltage follower circuit includes a second operational amplifier; the second operational amplifier includes a third input terminal, a fourth input terminal and a second output terminal, the third input terminal is electrically connected to the first output terminal, and the fourth input terminal is electrically connected to the second output terminal; The filtering circuit includes a fifth resistor and a first capacitor; the input end of the fifth resistor is electrically connected to the second output end, the output end of the fifth resistor is electrically connected to the input end of the first capacitor, the output end of the first capacitor is grounded, and the output end of the fifth resistor is also electrically connected to the signal acquisition unit.

9. The multi-channel biochemical analysis detector according to claim 5, characterized in that: Also includes: A constant current source circuit is used to form a differential voltage signal between the first signal interface and the second signal interface.

10. The multi-channel biochemical analysis detector according to claim 9, characterized in that: The constant current source circuit comprises a power chip, a sixth resistor and a ground terminal; Among them, the first end of the power chip is electrically connected to the input end of the sixth resistor, the second end of the power chip and the second spring needle are both electrically connected to the output end of the sixth resistor, and the first spring needle is electrically connected to the ground end.

11. The multi-channel biochemical analysis detector according to claim 4, characterized in that: The signal channel selection unit includes at least one selector, and the selector is electrically connected to the signal acquisition unit; the selector is used to select any one of all the signal access channels to be connected to the signal acquisition unit.

12. The multi-channel biochemical analysis detector according to claim 11, characterized in that: The selector includes N primary selectors and one secondary selector, the primary selector is electrically connected to the secondary selector, and the secondary selector is electrically connected to the signal acquisition unit; The primary selector is used to select any one of the corresponding multiple signal access channels to be connected to the secondary selector; The secondary selector is used to select one of the N primary selectors to be electrically connected to the signal acquisition unit; the secondary selector includes an M-to-one selector; Wherein, M and N are positive integers, N is greater than or equal to 2, and M is greater than or equal to N.

13. The multi-channel biochemical analysis detector according to claim 4, characterized in that: Also includes: at least one of a display management unit, a storage unit, a power management unit, an interaction unit, and a communication unit; The display management unit is used to drive a display screen to display the target detection index and / or the configuration information of the multi-channel biochemical analysis detector on the display screen; The storage unit is used to store the target signal and / or the target detection index; The power management unit is used to control the voltage, current and power of the multi-channel biochemical analysis detector; The interactive unit is used to provide an operation interface for the user, and to set the parameters of the multi-channel biochemical analysis detector in response to the user's operation; The communication unit is used to transmit the target detection index to the remote server, and forward the control instruction sent by the remote server to the control unit; Wherein, the display management unit, the storage unit, the power management unit, the interaction unit and the communication unit are all electrically connected to the control unit.

14. A control method for a multi-channel biochemical analysis detector, characterized in that: The multi-channel biochemical analysis detector is used to detect a biochemical sensor array, wherein the biochemical sensor array includes a plurality of biochemical sensors arranged in an array and a signal interface connected to the biochemical sensors; The multi-channel biochemical analysis detector comprises a fixing unit, and the fixing unit is used to fix the signal interface of the biochemical sensor array; The fixing unit comprises: a socket, a fixing plane, an in-place detection module, a connection module, a driving module and a control module; The in-position detection module, the driving module and the connecting module are all electrically connected to the control module; the connecting module is fixed to the driving module; The control method comprises: The control module controls the movement of the driving module in response to the in-place signal transmitted by the in-place detection module, and the driving module drives the connection module to move until the connection module contacts the signal interface and fixes the signal interface on the fixed plane; wherein the in-place signal is triggered and generated by the in-place detection module when it detects that the signal interface is inserted into the socket.

15. The control method according to claim 14, characterized in that: The multi-channel biochemical analysis detector further includes: a signal channel selection unit, a signal acquisition unit and a control unit, wherein the fixing unit, the signal channel selection unit and the signal acquisition unit are all electrically connected to the control unit, the connection module is electrically connected to the signal channel selection unit, and the signal channel selection unit is electrically connected to the signal acquisition unit; The control method further comprises: The control unit controls the signal channel selection unit to select the signal access channel of the biochemical sensor based on the fixing unit fixing the signal interface of the biochemical sensor array; The control unit controls the signal acquisition unit to acquire target signals of the biochemical sensors connected to the channel; The control unit performs data processing on the collected target signal to obtain a target detection index; Among them, the signal interface includes a first signal interface and multiple second signal interfaces, the first signal interface is electrically connected to the common end of the biochemical sensor, the second signal interface is electrically connected to the other end of the biochemical sensor in a one-to-one correspondence, and a signal access channel includes the first signal interface, one second signal interface and one biochemical sensor correspondingly connected between the first signal interface and the second signal interface.

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