Perfusion device and method of manufacture

Abstract

The invention discloses a perfusion device and a manufacturing method, the perfusion device is used for being connected with a blood pumping catheter, the perfusion device comprises a first shell, a second shell, a first piston rod and a second piston rod, the first shell defines a first flow channel and a second flow channel, the first flow channel comprises a first piston cavity, and the second flow channel comprises a second piston cavity; the second shell is connected with the first shell, a third flow channel and a fourth flow channel are defined by the second shell, the third flow channel comprises a third piston cavity, and the fourth flow channel comprises a fourth piston cavity; the first piston rod is movably connected with the first shell and the second shell, the first piston rod comprises a first piston head, a first connecting rod and a second piston head which are sequentially arranged, at least part of the first piston head is located in the first piston cavity, and at least part of the second piston head is located in the third piston cavity; the first piston cavity and the third piston cavity are used for injecting perfusate into the blood pumping catheter; the second piston rod is movably connected with the first shell and the second shell.

Description

Technical Field

[0001] This application belongs to the technical field of medical devices, and particularly relates to a perfusion device and a manufacturing method thereof. Background Art

[0002] A ventricular assist system is an assist system that can pump blood from the ventricle to other parts of the body. The ventricular assist system is often used in patients with heart weakness or heart failure and can partially or mostly replace the pumping function of the ventricle.

[0003] In the related art, the working instrument of the ventricular assist system often needs to be connected to a perfusion system so that the perfusion system can perfuse perfusion fluid into the working instrument and can extract waste liquid from the working instrument. A plunger pump is used in a related perfusion system to achieve the injection and suction of the perfusion fluid. However, there are many pipelines in the existing plunger pump system, resulting in complex connections, cumbersome manufacturing processes, and the internal pipelines are prone to kinking, causing the perfusion fluid to be blocked. Secondly, the pipelines are all connected by glue, which is easy to cause glue failure and perfusion fluid leakage, affecting the reliability of the product. Summary of the Invention

[0004] An embodiment of the present application provides a perfusion device with stable connection.

[0005] An embodiment of the first aspect of the present application provides a perfusion device, including a first housing, a second housing, a first piston rod, and a second piston rod. The first housing encloses a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber. The second housing is connected to the first housing, and the second housing encloses a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber. The first piston rod is movably connected to both the first housing and the second housing. The first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber. The first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter. The second piston rod is movably connected to both the first housing and the second housing. The second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber. The second piston chamber and the fourth piston chamber are used to suck the perfusion fluid in the blood pumping catheter.

[0006] According to the implementation manner of the first aspect of the present application, it further includes: a third housing located between the first housing and the second housing. The third housing connects the first housing and the second housing. The third housing encloses a fifth flow channel and a sixth flow channel. The fifth flow channel is communicated with both the first piston chamber and the third piston chamber, and the fifth flow channel is used to communicate with the blood pumping catheter. The sixth flow channel is communicated with both the second piston chamber and the fourth piston chamber, and the sixth flow channel is used to communicate with the blood pumping catheter.

[0007] According to an embodiment of the first aspect of the present application, the third housing further encloses and forms a seventh flow channel and an eighth flow channel. The seventh flow channel is in communication with both the first piston chamber and the third piston chamber, and the perfusion fluid flows into the first piston chamber or the third piston chamber through the seventh flow channel. The eighth flow channel is in communication with both the second piston chamber and the fourth piston chamber, and the perfusion fluid in the second piston chamber and the fourth piston chamber is discharged from the perfusion device through the eighth flow channel.

[0008] According to an embodiment of the first aspect of the present application, the fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel each include three mutually connected branch flow channels. The three branch flow channels in the fifth flow channel are respectively in communication with the first piston chamber, the third piston chamber, and the blood pumping catheter. The three branch flow channels in the sixth flow channel are respectively in communication with the second piston chamber, the fourth piston chamber, and the blood pumping catheter. The two branch flow channels in the seventh flow channel are respectively in communication with the first piston chamber and the third piston chamber. The two branch flow channels in the eighth flow channel are respectively in communication with the second piston chamber and the fourth piston chamber.

[0009] According to an embodiment of the first aspect of the present application, it further includes: one-way valves, which are provided between the first flow channel and the fifth flow channel, between the first flow channel and the seventh flow channel, between the third flow channel and the fifth flow channel, between the third flow channel and the seventh flow channel, between the second flow channel and the sixth flow channel, between the second flow channel and the eighth flow channel, between the fourth flow channel and the sixth flow channel, and between the fourth flow channel and the eighth flow channel. The one-way valves located between the seventh flow channel and the first flow channel and the third flow channel are used to allow the perfusion fluid to only flow from the seventh flow channel into the first flow channel and the third flow channel. The one-way valves located between the fifth flow channel and the first flow channel and the third flow channel are used to allow the perfusion fluid to only flow from the first flow channel and the third flow channel into the fifth flow channel. The one-way valves located between the sixth flow channel and the second flow channel and the fourth flow channel are used to allow the perfusion fluid to only flow from the sixth flow channel into the second flow channel and the fourth flow channel. The one-way valves located between the eighth flow channel and the second flow channel and the fourth flow channel are used to allow the perfusion fluid to only flow from the second flow channel and the fourth flow channel into the eighth flow channel.

[0010] According to an embodiment of the first aspect of the present application, the first flow channel further includes a first branch channel and a second branch channel. The first branch channel communicates the first piston chamber and the seventh flow channel, and the second branch channel communicates the first piston chamber and the fifth flow channel. The second flow channel further includes a third branch channel and a fourth branch channel. The third branch channel communicates the second piston chamber and the sixth flow channel, and the fourth branch channel communicates the second piston chamber and the eighth flow channel. The third flow channel further includes a fifth branch channel and a sixth branch channel. The fifth branch channel communicates the third piston chamber and the seventh flow channel, and the sixth branch channel communicates the third piston chamber and the fifth flow channel. The fourth flow channel further includes a seventh branch channel and an eighth branch channel. The seventh branch channel communicates the fourth piston chamber and the sixth flow channel, and the eighth branch channel communicates the fourth piston chamber and the eighth flow channel.

[0011] According to an embodiment of the first aspect of the present application, the third housing and at least one of the fifth, sixth, seventh, and eighth flow channels therein are integrally formed by injection molding.

[0012] According to an embodiment of the first aspect of the present application, the first piston chamber and the third piston chamber are spaced apart along a first direction, the second piston chamber and the fourth piston chamber are spaced apart along the first direction, and the first piston rod and the second piston rod both extend along the first direction.

[0013] According to an embodiment of the first aspect of the present application, it further includes: a driving mechanism, which is connected to the first piston rod and the second piston rod, and the driving mechanism is used to drive the first piston rod and the second piston rod to move along the first direction, thereby changing the pressures in the first piston chamber, the second piston chamber, the third piston chamber, and the fourth piston chamber.

[0014] According to an embodiment of the first aspect of the present application, the first housing and at least one of the first and second flow channels therein are integrally formed by injection molding, and the second housing and at least one of the third and fourth flow channels therein are integrally formed by injection molding.

[0015] On the other hand, an embodiment of the present application further provides a manufacturing method of a perfusion device, including the following steps: providing a first housing and a second housing, both the first housing and the second housing are integrally formed by injection molding, the first housing encloses to form a first flow channel and a second flow channel, the first flow channel includes a first piston chamber, the second flow channel includes a second piston chamber, the second housing encloses to form a third flow channel and a fourth flow channel, the third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; providing a first piston rod and a second piston rod, the first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence, and the second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence; movably connecting the first piston rod to the first housing and the second housing, at least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber; movably connecting the second piston rod to the first housing and the second housing, at least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber.

[0016] According to an embodiment of the second aspect of the present application, it further includes: providing a driving mechanism and connecting the driving mechanism to the first piston rod and the second piston rod.

[0017] According to an embodiment of the second aspect of the present application, it further includes: providing a third housing, the third housing is integrally formed by injection molding, the third housing encloses to form a fifth flow channel, a sixth flow channel, a seventh flow channel, and an eighth flow channel; connecting the first housing, the second housing, and the third housing, and the first housing and the second housing are located at both ends of the third housing in the first direction.

[0018] The perfusion device according to an embodiment of the present application includes a first housing, a second housing, a first piston rod, and a second piston rod. The first housing encloses a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber. The second housing is connected to the first housing and encloses a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber. The first piston rod is movably connected to both the first housing and the second housing. The first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence. At least a part of the first piston head is located in the first piston chamber, and at least a part of the second piston head is located in the third piston chamber. The first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter. The second piston rod is movably connected to both the first housing and the second housing. The second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence. At least a part of the third piston head is located in the second piston chamber, and at least a part of the fourth piston head is located in the fourth piston chamber. The second piston chamber and the fourth piston chamber are used to suck the perfusion fluid in the blood pumping catheter. In the present application, by integrally forming both the first housing and the second housing to form flow channels inside, there is no need for catheter connection inside the perfusion device, which can avoid catheter kinking, reduce the amount of glue used, and improve the connection strength, thereby improving the reliability of the product. Secondly, the absence of catheters inside the perfusion device also reduces the process of pipeline connection and improves the manufacturing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required to be used in the embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0020] Figure 1 It is a connection relationship diagram of a perfusion device and a blood pumping catheter according to some embodiments of the present application;

[0021] Figure 2 It shows a front view of an exemplary perfusion device;

[0022] Figure 3 It shows an exploded structural schematic diagram of an exemplary perfusion device after hiding the first piston rod and the second piston rod;

[0023] Figure 4 It shows a top view of an exemplary perfusion device;

[0024] Figure 5 It shows an exemplary Figure 4 Cross-sectional view of the filling device in the O-O section;

[0025] Figure 6 It shows an exemplary Figure 4 Cross-sectional view of the filling device in the P-P section;

[0026] Figure 7 Shows an exemplary Figure 4 Cross-sectional view of the filling device in the Q-Q section;

[0027] Figure 8 Shows an exemplary Figure 4 Cross-sectional view of the filling device in the R-R section;

[0028] Figure 9 Shows an exemplary Figure 4 Cross-sectional view of the filling device in the V-V section;

[0029] Figure 10 Bottom view of an exemplary third housing;

[0030] Figure 11 Shows an exemplary Figure 10 Cross-sectional view of the third housing in the G-G section;

[0031] Figure 12 Shows an exemplary Figure 10 Cross-sectional view of the third housing in the H-H section;

[0032] Figure 13 Bottom view of an exemplary first housing;

[0033] Figure 14 Shows an exemplary Figure 13 Cross-sectional view of the first housing in the D-D section;

[0034] Figure 15 Shows an exemplary Figure 13 Cross-sectional view of the first housing in the E-E section;

[0035] Figure 16 Top view of an exemplary second housing;

[0036] Figure 17 Shows an exemplary Figure 16 Cross-sectional view of the second housing in the K-K section;

[0037] Figure 18 Shows an exemplary Figure 16 Cross-sectional view of the second housing in the L-L section.

[0038] Reference numerals:

[0039] 10, perfusion device; 20, blood pumping catheter; 30, housing; 40, perfusion system; 50, discharge system;

[0040] 110, First housing; 120, First flow channel; 121, First piston chamber; 122, First branch channel; 123, Second branch channel; 130, Second flow channel; 131, Second piston chamber; 132, Third branch channel; 133, Fourth branch channel;

[0041] 210, Second housing; 220, Third flow channel; 221, Third piston chamber; 222, Fifth branch channel; 223, Sixth branch channel; 230, Fourth flow channel; 231, Fourth piston chamber; 232, Seventh branch channel; 233, Eighth branch channel;

[0042] 300, First piston rod; 310, First piston head; 320, Second piston head; 330, First connecting rod;

[0043] 400, Second piston rod; 410, Third piston head; 420, Fourth piston head; 430, Second connecting rod;

[0044] 500, Driving mechanism; 510, Gear;

[0045] 610, Third housing; 620, Fifth flow channel; 630, Sixth flow channel; 640, Seventh flow channel; 650, Eighth flow channel; 660, Accommodation chamber; 670, Through hole; 680, Branch flow channel;

[0046] 700, Check valve;

[0047] 800, Sealing ring;

[0048] x, First direction; y, Second direction. Detailed implementation manners

[0049] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In order to make the objectives, technical solutions and advantages of the present application clearer and more understandable, the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application, rather than limiting the present application. For those skilled in the art, the present application can be implemented without some of these specific details. The following description of the embodiments is only intended to provide a better understanding of the present application by showing examples of the present application.

[0050] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising..." does not exclude the presence of additional identical elements in the process, method, article or device comprising the said element.

[0051] The applicant has found that in the prior art, there are many pipelines in the plunger pump system, resulting in complex connections, cumbersome manufacturing processes, and the internal pipelines are prone to kinking, causing obstruction to the flow of the perfusion fluid. Secondly, the pipelines are all connected by glue, which is prone to glue failure and causes leakage of the perfusion fluid, affecting the reliability of the product.

[0052] In view of the above problems, the applicant proposes a perfusion device, which includes a first housing, a second housing, a first piston rod and a second piston rod. The first housing encloses a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber. The second housing is connected to the first housing, and the second housing encloses a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber. The first piston rod is movably connected to both the first housing and the second housing. The first piston rod includes a first piston head, a first connecting rod and a second piston head arranged in sequence. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber. The first piston chamber and the third piston chamber are used to inject the perfusion fluid into the blood pump catheter. The second piston rod is movably connected to both the first housing and the second housing. The second piston rod includes a third piston head, a second connecting rod and a fourth piston head arranged in sequence. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber. The second piston chamber and the fourth piston chamber are used to suck the perfusion fluid in the blood pump catheter.

[0053] The perfusion device provided by the present application is integrally formed with both the first housing and the second housing to form flow channels inside, so that there is no need for catheter connection inside the perfusion device. While avoiding catheter kinking, it can also reduce the amount of glue used and improve the connection strength, thereby improving the reliability of the product. Secondly, the absence of catheters inside the perfusion device also reduces the process of pipeline connection and improves the manufacturing efficiency.

[0054] The perfusion device and manufacturing method provided by the embodiments of the present application will be introduced below in conjunction with the accompanying drawings. It should be noted that in the accompanying drawings, the x-direction is the first direction and the y-direction is the second direction. In the drawings, for the convenience of drawing, the dimensions in the drawings do not necessarily have the same proportion as the actual dimensions.

[0055] Please refer to Figures 1 to 6 , Figure 1 which is a connection diagram of the perfusion device and the blood pumping catheter for some embodiments of the present application; Figure 2 showing a front view of an exemplary perfusion device; Figure 3 showing an exploded schematic view of an exemplary perfusion device with the first piston rod and the second piston rod hidden; Figure 4 showing a top view of an exemplary perfusion device; Figure 5 showing an exemplary Figure 4 cross-sectional view of the filling device in the O-O section; Figure 6 showing an exemplary Figure 4 cross-sectional view of the filling device in the P-P section.

[0056] As Figures 1 to 6 shown, the present application provides a perfusion device 10 for connecting with a blood pumping catheter 20. The perfusion device 10 includes a first housing 110, a second housing 210, a first piston rod 300, and a second piston rod 400. The first housing 110 encloses a first flow channel 120 and a second flow channel 130. The first flow channel 120 includes a first piston chamber 121, and the second flow channel 130 includes a second piston chamber 131. The second housing 210 is connected to the first housing 110, and the second housing 210 encloses a third flow channel 220 and a fourth flow channel 230. The third flow channel 220 includes a third piston chamber 221, and the fourth flow channel 230 includes a fourth piston chamber 231. The first piston rod 300 is movably connected to both the second housing 210 and the first housing 110. The first piston rod 300 includes a first piston head 310, a first connecting rod 330, and a second piston head 320 arranged in sequence. At least part of the first piston head 310 is located in the first piston chamber 121, and at least part of the second piston head 320 is located in the third piston chamber 221. The first piston chamber 121 and the third piston chamber 221 are used to inject perfusion fluid (not shown) into the blood pumping catheter 20. The second piston rod 400 is movably connected to both the second housing 210 and the first housing 110. The second piston rod 400 includes a third piston head 410, a second connecting rod 430, and a fourth piston head 420 arranged in sequence. At least part of the third piston head 410 is located in the second piston chamber 131, and at least part of the fourth piston head 420 is located in the fourth piston chamber 231. The second piston chamber 131 and the fourth piston chamber 231 are used to suck the perfusion fluid in the blood pumping catheter 20.

[0057] Optionally, the first housing 110 and at least one of the first flow channel 120 and the second flow channel 130 therein are integrally formed by injection molding, and the second housing 210 and at least one of the third flow channel 220 and the fourth flow channel 230 therein are integrally formed by injection molding. Preferably, the first flow channel 120, the second flow channel 130 and the first housing 110 are all integrally formed, and the third flow channel 220, the fourth flow channel 230 and the second housing 210 are all integrally formed. It can be understood that after the first housing 110 and the second housing 210 are integrally formed by injection molding, the first flow channel 120 and the second flow channel 130 have been formed in the first housing 110, and the third flow channel 220 and the fourth flow channel 230 have been formed in the second housing 210. When there is a flow channel in the housing that is not integrally injection molded with the housing, the flow channel can be processed in the housing by later methods such as digging holes and etching the housing.

[0058] Optionally, the first housing 110 and the second housing 210 are connected by connecting members such as bolts and link rods or by means such as welding and bonding.

[0059] Optionally, the first piston chamber 121 and the third piston chamber 221 are arranged at intervals along the first direction (the x direction in the figure), the second piston chamber 131 and the fourth piston chamber 231 are arranged at intervals along the first direction x, and both the first piston rod 300 and the second piston rod 400 extend along the first direction x.

[0060] Optionally, the first flow channel 120 and the third flow channel 220 form a perfusion system 40, and the perfusion system 40 is used to deliver perfusion fluid to the blood pumping catheter 20. The second flow channel 130 and the fourth flow channel 230 form a discharge system 50, and the discharge system 50 is used to discharge the perfusion fluid in the blood pumping catheter 20.

[0061] For the perfusion device 10 provided in this embodiment, by integrally forming both the first housing 110 and the second housing 210 and forming flow channels inside, there is no need for catheter connection inside the perfusion device 10. While avoiding catheter kinking, it can also reduce the amount of glue used and improve the connection strength, thereby improving the reliability of the product. Secondly, the absence of catheters inside the perfusion device also reduces the process of pipeline connection and improves the manufacturing efficiency.

[0062] Please refer to Figures 1 to 9 , Figure 7 which shows a cross-sectional view of an exemplary Figure 4 filling device in the Q-Q cross-section; Figure 8 which shows a cross-sectional view of an exemplary Figure 4 filling device in the R-R cross-section; Figure 9 which shows a cross-sectional view of an exemplary Figure 4 filling device in the V-V cross-section.

[0063] As shown in Figures 1 to 9As shown, in some alternative embodiments, the perfusion device 10 further includes a driving mechanism 500. The driving mechanism 500 is connected to the first piston rod 300 and the second piston rod 400, and is configured to drive the first piston rod 300 and the second piston rod 400 to move in the first direction x, thereby changing the pressures in the first piston chamber 121, the second piston chamber 131, the third piston chamber 221, and the fourth piston chamber 231.

[0064] When the first piston rod 300 moves towards the first piston chamber 121, the first piston head 310 squeezes the first piston chamber 121, causing the pressure in the first piston chamber 121 to increase. The perfusion fluid in the first piston chamber 121 is then pressed into the blood pumping catheter 20. At the same time, due to the movement of the second piston head 320, the volume in the third piston chamber 221 increases and the pressure decreases, and the perfusion fluid is suctioned into the third piston chamber 221. When the first piston rod 300 moves towards the third piston chamber 221, the second piston head 320 squeezes the third piston chamber 221, causing the pressure in the third piston chamber 221 to increase. The perfusion fluid in the third piston chamber 221 is then pressed into the blood pumping catheter 20. At the same time, due to the movement of the first piston head 310, the volume in the first piston chamber 121 increases and the pressure decreases, and the perfusion fluid is suctioned into the first piston chamber 121.

[0065] When the second piston rod 400 moves towards the second piston chamber 131, the third piston head 410 squeezes the second piston chamber 131, causing the pressure in the second piston chamber 131 to increase. The perfusion fluid in the second piston chamber 131 is then pressed out. At the same time, due to the movement of the fourth piston head 420, the volume of the fourth piston chamber 231 increases and the pressure decreases, and the perfusion fluid in the blood pumping catheter 20 is suctioned into the fourth piston chamber 231. When the second piston rod 400 moves towards the fourth piston chamber 231, the fourth piston head 420 squeezes the fourth piston chamber 231, causing the pressure in the fourth piston chamber 231 to increase. The perfusion fluid in the fourth piston chamber 231 is then pressed out. At the same time, due to the movement of the third piston head 410, the volume of the second piston chamber 131 increases and the pressure decreases, and the perfusion fluid in the blood pumping catheter 20 is suctioned into the second piston chamber 131.

[0066] Optionally, the driving mechanism 500 can independently drive the first piston rod 300 and the second piston rod 400 respectively. For example, the driving mechanism 500 includes two independently operating motors, and the two motors respectively drive the first piston rod 300 and the second piston rod 400 to move. The driving mechanism 500 can also drive the first piston rod 300 and the second piston rod 400 to move in a linked manner.

[0067] The perfusion device 10 provided in this embodiment enables the first piston rod 300 to control the pressures of the first piston chamber 121 and the third piston chamber 221 simultaneously. Both the first piston chamber 121 and the third piston chamber 221 are used to deliver perfusion fluid to the blood pumping catheter 20. When the first piston rod 300 moves, there is always one piston chamber delivering perfusion fluid to the blood pumping catheter 20, and the other piston chamber replenishing the perfusion fluid, thereby ensuring that the perfusion fluid in the blood pumping catheter 20 is not interrupted. By enabling the second piston rod 400 to control the pressures of the second piston chamber 131 and the fourth piston chamber 231 simultaneously. Both the second piston chamber 131 and the fourth piston chamber 231 are used to suck the perfusion fluid in the blood pumping catheter 20. When the second piston rod 400 moves, there is always one piston chamber sucking the perfusion fluid in the blood pumping catheter 20, and the other piston chamber discharging the perfusion fluid, thereby ensuring that the perfusion fluid in the blood pumping catheter 20 does not accumulate. By providing four piston chambers in pairs, the smooth operation of the perfusion fluid in the blood pumping catheter 20 is jointly ensured.

[0068] In some alternative embodiments, the driving mechanism 500 includes a gear 510. Rack teeth (not shown) that mesh with the gear 510 are provided on both the first piston rod 300 and the second piston rod 400. The rack teeth extend along the first direction x.

[0069] Optionally, the rack teeth are provided on the first connecting rod 330 and the second connecting rod 430.

[0070] Optionally, the first piston rod 300 and the second piston rod 400 are spaced apart along the second direction (the y direction in the figure). The first piston rod 300 and the second piston rod 400 are located on both sides of the gear 510 in the second direction y. Among them, the first direction x and the second direction y intersect. When the gear 510 rotates in one direction, both the first piston rod 300 and the second piston rod 400 move along the first direction x, but the moving directions of the first piston rod 300 and the second piston rod 400 are opposite. When the gear 510 moves in the reverse direction, the first piston rod 300 and the second piston rod 400 will also move in the reverse direction along the first direction x. By reciprocally rotating the gear 510, the driving mechanism 500 can drive the first piston rod 300 and the second piston rod 400 to continuously reciprocate along the first direction x.

[0071] In the perfusion device 10 provided in this embodiment, by arranging the first piston rod 300 and the second piston rod 400 on both sides of the gear 510, and the rack teeth on both the first piston rod 300 and the second piston rod 400 mesh with the gear 510, when the gear 510 rotates, both the first piston rod 300 and the second piston rod 400 will be driven by the gear 510, thereby enabling the perfusion and suction of the blood pumping catheter 20 by the perfusion device 10 to be continuous without interruption, ensuring the continuity of the perfusion fluid.

[0072] Please refer to Figures 1 to 12 , Figure 10Shows a bottom view of an exemplary third housing; Figure 11 Shows an exemplary Figure 10 Cross-sectional view of the third housing in the G-G section of Figure 12 Shows an exemplary Figure 10 Cross-sectional view of the third housing in the H-H section of

[0073] As Figures 1 to 12 As shown, in some alternative embodiments, the perfusion device 10 further includes a third housing 610. The third housing 610 is located between the first housing 110 and the second housing 210, and the third housing 610 connects the first housing 110 and the second housing 210. The third housing 610 encloses and forms a fifth flow channel 620 and a sixth flow channel 630. The fifth flow channel 620 is in communication with both the first piston chamber 121 and the third piston chamber 221, and the fifth flow channel 620 is used to communicate with the blood pumping catheter 20. The sixth flow channel 630 is in communication with both the second piston chamber 131 and the fourth piston chamber 231, and the sixth flow channel 630 is used to communicate with the blood pumping catheter 20.

[0074] Optionally, the third housing 610 and at least one of the fifth flow channel 620 and the sixth flow channel 630 therein are integrally formed by injection molding. The third housing 610 is connected to the first housing 110 and the second housing 210 by connecting members such as bolts and linkages or by means such as welding and gluing.

[0075] Adopting the process of separately injection molding the first housing 110, the second housing 210, and the third housing 610 and then connecting them, the flow channels on the first housing 110, the second housing 210, and the third housing 610 all have openings in the first direction x, avoiding the blockage of the flow channels by raw materials during injection molding, thereby improving the yield of injection molding. In addition, the risk of blockage of the flow channels by injection molding raw materials can be further reduced by reserving gates communicating with the flow channels on the first housing 110, the second housing 210, and the third housing 610. After hardening and forming, the gates can be sealed with plugs.

[0076] For the perfusion device 10 provided in this embodiment, by making the first housing 110, the second housing 210, and the third housing 610 all integrally formed by injection molding, not only the number of internal pipelines is reduced, but also the process manufacturing and connection are facilitated, and the yield of injection molding is improved.

[0077] In some alternative embodiments, the third housing 610 also encloses and forms a seventh flow channel 640 and an eighth flow channel 650. The seventh flow channel 640 is in communication with both the first piston chamber 121 and the third piston chamber 221, and the perfusion liquid flows into the first piston chamber 121 or the third piston chamber 221 through the seventh flow channel 640. The eighth flow channel 650 is in communication with both the second piston chamber 131 and the fourth piston chamber 231, and the perfusion liquid in the second piston chamber 131 and the fourth piston chamber 231 is discharged from the perfusion device 10 through the eighth flow channel 650.

[0078] Optionally, the third housing 610 and at least one of the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 therein are integrally formed by injection molding. Preferably, the third housing 610 and the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 therein are all integrally formed by injection molding. It can be understood that after the third housing 610 is integrally formed by injection molding, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 are generated inside.

[0079] It can be understood that the first housing 110, the second housing 210, and the third housing 610 together form the housing 30 of the perfusion device 10, and the housing 30 encloses to form a perfusion system 40 and a discharge system 50. The perfusion system 40 includes a first flow channel 120, a third flow channel 220, a fifth flow channel 620, and a seventh flow channel 640, and the discharge system 50 includes a second flow channel 130, a fourth flow channel 230, a sixth flow channel 630, and an eighth flow channel 650.

[0080] Optionally, the fifth flow channel 620 and the sixth flow channel 630 can be externally connected to the blood pumping catheter 20 through a catheter (not shown). The seventh flow channel 640 is communicated with an external perfusion fluid input end, such as a water tank, and the eighth flow channel 650 is communicated with an external waste liquid collection device (not shown). The external perfusion fluid input end flows into the perfusion device 10 through the seventh flow channel 640. Then, the perfusion fluid is sucked and pressed into the fifth flow channel 620 by the first piston chamber 121 or the third piston chamber 221. The fifth flow channel 620 inputs the perfusion fluid into the blood pumping catheter 20. The waste liquid in the blood pumping catheter 20 flows back into the perfusion device 10 through the sixth flow channel 630, and is sucked and pressed into the eighth flow channel 650 by the second piston chamber 131 or the fourth piston chamber 231, and flows out of the perfusion device 10 through the eighth flow channel 650.

[0081] Optionally, the third housing 610 also encloses to form a receiving cavity 660 and a through hole 670. The receiving cavity 660 is used to receive the driving mechanism 500. The through hole 670 penetrates the third housing 610 along the first direction x. The through hole 670 is used to enable the first piston rod 300 and the second piston rod 400 to extend from the first housing 110 to the second housing 210.

[0082] In some alternative embodiments, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 each include three interconnected branch flow channels 680. The three branch flow channels 680 in the fifth flow channel 620 are respectively connected to the first piston chamber 121, the third piston chamber 221, and the blood pumping catheter 20. The three branch flow channels 680 in the sixth flow channel 630 are respectively connected to the second piston chamber 131, the fourth piston chamber 231, and the blood pumping catheter 20. Two of the branch flow channels 680 in the seventh flow channel 640 are respectively connected to the first piston chamber 121 and the third piston chamber 221, and the other branch flow channel 680 is for connection to an external perfusion fluid input end. Two of the branch flow channels 680 in the eighth flow channel 650 are respectively connected to the second piston chamber 131 and the fourth piston chamber 231, and the other branch flow channel 680 is for connection to an external waste liquid collection device.

[0083] Among them, the branch flow channels 680 are also integrally formed by injection molding. The three interconnected branch flow channels 680 in the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 can be understood as a structure similar to a tee, that is, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 can be regarded as four tees. However, the fifth flow channel 620, the sixth flow channel 630, the seventh flow channel 640, and the eighth flow channel 650 in the present application are formed synchronously during the injection molding of the third housing 610. Compared with the solution of using finished tees and conduits for connection, this solution reduces the number of pipeline connections, reduces the glue usage, and avoids internal pipeline kinking.

[0084] Please refer to Figures 1 to 18 , Figure 13 showing a bottom view of an exemplary first housing; Figure 14 showing an exemplary Figure 13 cross-sectional view of the first housing in the D-D section of Figure 15 showing an exemplary Figure 13 cross-sectional view of the first housing in the E-E section of Figure 16 showing a top view of an exemplary second housing; Figure 17 showing an exemplary Figure 16 cross-sectional view of the second housing in the K-K section of Figure 18 showing an exemplary Figure 16 cross-sectional view of the second housing in the L-L section of

[0085] As Figures 1 to 18As shown, in some alternative embodiments, the first flow channel 120 further includes a first branch channel 122 and a second branch channel 123. The first branch channel 122 communicates with the first piston chamber 121 and the seventh flow channel 640, and the second branch channel 123 communicates with the first piston chamber 121 and the fifth flow channel 620. The perfusion fluid in the seventh flow channel 640 can enter the first piston chamber 121 through the first branch channel 122 and then flow into the fifth flow channel 620 through the second branch channel 123. The second flow channel 130 further includes a third branch channel 132 and a fourth branch channel 133. The third branch channel 132 communicates with the second piston chamber 131 and the sixth flow channel 630, and the fourth branch channel 133 communicates with the second piston chamber 131 and the eighth flow channel 650. The perfusion fluid in the sixth flow channel 630 can flow into the second piston chamber 131 through the third branch channel 132 and then flow into the eighth flow channel 650 through the fourth branch channel 133. The third flow channel 220 further includes a fifth branch channel 222 and a sixth branch channel 223. The fifth branch channel 222 communicates with the third piston chamber 221 and the seventh flow channel 640, and the sixth branch channel 223 communicates with the third piston chamber 221 and the fifth flow channel 620. The perfusion fluid in the seventh flow channel 640 can enter the third piston chamber 221 through the fifth branch channel 222 and then flow into the fifth flow channel 620 through the sixth branch channel 223. The fourth flow channel 230 further includes a seventh branch channel 232 and an eighth branch channel 233. The seventh branch channel 232 communicates with the fourth piston chamber 231 and the sixth flow channel 630, and the eighth branch channel 233 communicates with the fourth piston chamber 231 and the eighth flow channel 650. The perfusion fluid in the sixth flow channel 630 can flow into the fourth piston chamber 231 through the seventh branch channel 232 and then flow into the eighth flow channel 650 through the eighth branch channel 233.

[0086] The first branch channel 122, the second branch channel 123, the third branch channel 132, the fourth branch channel 133, the fifth branch channel 222, the sixth branch channel 223, the seventh branch channel 232 and the eighth branch channel 233 and the housing enclosing each branch channel are integrally formed by injection molding.

[0087] In some alternative embodiments, the perfusion device 10 may further include a one-way valve 700. One-way valves 700 are provided between the first flow channel 120 and the fifth flow channel 620, between the first flow channel 120 and the seventh flow channel 640, between the third flow channel 220 and the fifth flow channel 620, between the third flow channel 220 and the seventh flow channel 640, between the second flow channel 130 and the sixth flow channel 630, between the second flow channel 130 and the eighth flow channel 650, between the fourth flow channel 230 and the sixth flow channel 630, and between the fourth flow channel 230 and the eighth flow channel 650.

[0088] The one-way valve 700 located between the seventh flow channel 640 and the first flow channel 120 and the third flow channel 220 is used to allow the perfusion fluid to only flow from the seventh flow channel 640 into the first flow channel 120 and the third flow channel 220. The one-way valve 700 located between the fifth flow channel 620 and the first flow channel 120 and the third flow channel 220 is used to allow the perfusion fluid to only flow from the first flow channel 120 and the third flow channel 220 into the fifth flow channel 620. The one-way valve 700 located between the sixth flow channel 630 and the second flow channel 130 and the fourth flow channel 230 is used to allow the perfusion fluid to only flow from the sixth flow channel 630 into the second flow channel 130 and the fourth flow channel 230. The one-way valve 700 located between the eighth flow channel 650 and the second flow channel 130 and the fourth flow channel 230 is used to allow the perfusion fluid to only flow from the second flow channel 130 and the fourth flow channel 230 into the eighth flow channel 650.

[0089] Optionally, the one-way valve 700 is located between the first branch channel 122 and the seventh flow channel 640, between the second branch channel 123 and the fifth flow channel 620, between the third branch channel 132 and the sixth flow channel 630, between the fourth branch channel 133 and the eighth flow channel 650, between the fifth branch channel 222 and the seventh flow channel 640, between the sixth branch channel 223 and the fifth flow channel 620, between the seventh branch channel 232 and the sixth flow channel 630, and between the eighth branch channel 233 and the eighth flow channel 650.

[0090] Optionally, the perfusion device 10 may further include a sealing ring 800. Between the first flow channel 120 and the fifth flow channel 620, between the first flow channel 120 and the seventh flow channel 640, between the third flow channel 220 and the fifth flow channel 620, between the third flow channel 220 and the seventh flow channel 640, between the second flow channel 130 and the sixth flow channel 630, between the second flow channel 130 and the eighth flow channel 650, between the fourth flow channel 230 and the sixth flow channel 630, and between the fourth flow channel 230 and the eighth flow channel 650 are all sealed and connected through the sealing ring 800.

[0091] An embodiment of the second aspect of the present application further provides a manufacturing method of the perfusion device 10, including the following steps:

[0092] Step S1, providing a first housing 110 and a second housing 210. Both the first housing 110 and the second housing 210 are integrally formed by injection molding. The first housing 110 encloses to form the first flow channel 120 and the second flow channel 130. The first flow channel 120 includes a first piston chamber 121, and the second flow channel 130 includes a second piston chamber 131. The second housing 210 encloses to form the third flow channel 220 and the fourth flow channel 230. The third flow channel 220 includes a third piston chamber 221, and the fourth flow channel 230 includes a fourth piston chamber 231;

[0093] Step S2, provide a first piston rod 300 and a second piston rod 400. The first piston rod 300 includes a first piston head 310, a first connecting rod 330, and a second piston head 320 arranged in sequence. The second piston rod 400 includes a third piston head 410, a second connecting rod 430, and a fourth piston head 420 arranged in sequence;

[0094] Step S3, movably connect the first piston rod 300 to the first housing 110 and the second housing 210. At least part of the first piston head 310 is located in the first piston chamber 121, and at least part of the second piston head 320 is located in the third piston chamber 221;

[0095] Step S4, movably connect the second piston rod 400 to the first housing 110 and the second housing 210. At least part of the third piston head 410 is located in the second piston chamber 131, and at least part of the fourth piston head 420 is located in the fourth piston chamber 231.

[0096] Since the manufacturing method of the perfusion device 10 provided in the second aspect embodiment of the present application is used to manufacture the perfusion device 10 of any embodiment in the first aspect above, the manufacturing method of the perfusion device 10 provided in the second aspect embodiment of the present application has the beneficial effects of the perfusion device 10 of any embodiment in the first aspect above, which will not be elaborated here.

[0097] In some optional embodiments, the manufacturing method of the perfusion device 10 further includes the following steps:

[0098] Step S5, provide a driving mechanism 500 and connect the driving mechanism 500 to the first piston rod 300 and the second piston rod 400.

[0099] Optionally, step S5 is after step S4.

[0100] In some optional embodiments, the manufacturing method of the perfusion device 10 further includes the following steps:

[0101] Step S6, provide a third housing 610. The third housing 610 is integrally formed by injection molding. The third housing 610 encloses a fifth flow channel 620, a sixth flow channel 630, a seventh flow channel 640, and an eighth flow channel 650;

[0102] Step S7, connect the first housing 110, the second housing 210, and the third housing 610. The first housing 110 and the second housing 210 are located at both ends of the third housing 610 in the first direction x.

[0103] Connect the first housing, the second housing, and the third housing. The first housing and the second housing are located at both ends of the third housing in the first direction.

[0104] Optionally, step S6 is after step S5.

[0105] As described above, this is only the specific implementation manner of the present application. Those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working processes of the systems, modules, and units described above can refer to the corresponding processes in the foregoing method embodiments, and will not be elaborated herein. It should be understood that the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present application.

Claims

1. An infusion device for connection with a blood pumping catheter, characterized in that, Comprising: A first housing which encloses and forms a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber; A second housing connected to the first housing, which encloses and forms a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; A first piston rod movably connected to both the first housing and the second housing. The first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber. The first piston chamber and the third piston chamber are used to inject perfusion fluid into the blood pumping catheter; A second piston rod movably connected to both the first housing and the second housing. The second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber. The second piston chamber and the fourth piston chamber are used to suck the perfusion fluid in the blood pumping catheter.

2. The perfusion device according to claim 1, characterized in that, Further comprising: A third housing located between the first housing and the second housing. The third housing connects the first housing and the second housing, and encloses and forms a fifth flow channel and a sixth flow channel. The fifth flow channel is communicated with both the first piston chamber and the third piston chamber, and the fifth flow channel is used to communicate with the blood pumping catheter; the sixth flow channel is communicated with both the second piston chamber and the fourth piston chamber, and the sixth flow channel is used to communicate with the blood pumping catheter.

3. The perfusion device according to claim 2, characterized in that, The third housing further encloses and forms a seventh flow channel and an eighth flow channel. The seventh flow channel is communicated with both the first piston chamber and the third piston chamber, and the perfusion fluid flows into the first piston chamber or the third piston chamber through the seventh flow channel. The eighth flow channel is communicated with both the second piston chamber and the fourth piston chamber, and the perfusion fluid in the second piston chamber and the fourth piston chamber is discharged from the perfusion device through the eighth flow channel.

4. The perfusion device according to claim 3, wherein The fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel each include three mutually connected branch flow channels. The three branch flow channels in the fifth flow channel are respectively communicated with the first piston chamber, the third piston chamber, and the blood pumping catheter. The three branch flow channels in the sixth flow channel are respectively communicated with the second piston chamber, the fourth piston chamber, and the blood pumping catheter. The two branch flow channels in the seventh flow channel are respectively communicated with the first piston chamber and the third piston chamber. The two branch flow channels in the eighth flow channel are respectively communicated with the second piston chamber and the fourth piston chamber.

5. The perfusion device according to claim 3, wherein Further comprising: One-way valves are provided between the first flow channel and the fifth flow channel, between the first flow channel and the seventh flow channel, between the third flow channel and the fifth flow channel, between the third flow channel and the seventh flow channel, between the second flow channel and the sixth flow channel, between the second flow channel and the eighth flow channel, between the fourth flow channel and the sixth flow channel, and between the fourth flow channel and the eighth flow channel. The one-way valve located between the seventh flow channel and the first flow channel and the third flow channel is configured to allow the perfusion fluid to only flow from the seventh flow channel into the first flow channel and the third flow channel. The one-way valve located between the fifth flow channel and the first flow channel and the third flow channel is configured to allow the perfusion fluid to only flow from the first flow channel and the third flow channel into the fifth flow channel. The one-way valve located between the sixth flow channel and the second flow channel and the fourth flow channel is configured to allow the perfusion fluid to only flow from the sixth flow channel into the second flow channel and the fourth flow channel. The one-way valve located between the eighth flow channel and the second flow channel and the fourth flow channel is configured to allow the perfusion fluid to only flow from the second flow channel and the fourth flow channel into the eighth flow channel.

6. The perfusion device according to claim 3, characterized in that, The first flow channel further includes a first branch channel and a second branch channel. The first branch channel connects the first piston chamber and the seventh flow channel, and the second branch channel connects the first piston chamber and the fifth flow channel. The second flow channel further includes a third branch channel and a fourth branch channel. The third branch channel connects the second piston chamber and the sixth flow channel, and the fourth branch channel connects the second piston chamber and the eighth flow channel. The third flow channel further includes a fifth branch channel and a sixth branch channel. The fifth branch channel connects the third piston chamber and the seventh flow channel, and the sixth branch channel connects the third piston chamber and the fifth flow channel. The fourth flow channel further includes a seventh branch channel and an eighth branch channel. The seventh branch channel connects the fourth piston chamber and the sixth flow channel, and the eighth branch channel connects the fourth piston chamber and the eighth flow channel.

7. The perfusion device according to claim 3, wherein The third housing is integrally formed by injection molding with at least one of the fifth flow channel, the sixth flow channel, the seventh flow channel, and the eighth flow channel therein.

8. The perfusion device according to claim 1, wherein, The first piston chamber and the third piston chamber are spaced apart along a first direction. The second piston chamber and the fourth piston chamber are spaced apart along the first direction. The first piston rod and the second piston rod both extend along the first direction.

9. The perfusion device according to claim 8, wherein, Further included is: A driving mechanism, which is connected to the first piston rod and the second piston rod. The driving mechanism is configured to drive the first piston rod and the second piston rod to move along the first direction, thereby changing the pressures in the first piston chamber, the second piston chamber, the third piston chamber, and the fourth piston chamber.

10. The perfusion device according to claim 1, characterized in that, The first housing is integrally formed by injection molding with at least one of the first flow channel and the second flow channel therein. The second housing is integrally formed by injection molding with at least one of the third flow channel and the fourth flow channel therein.

11. A manufacturing method of an infusion device, characterized in that, Including the following steps: Provide a first housing and a second housing, both the first housing and the second housing are integrally formed by injection molding. The first housing encloses a first flow channel and a second flow channel. The first flow channel includes a first piston chamber, and the second flow channel includes a second piston chamber. The second housing encloses a third flow channel and a fourth flow channel. The third flow channel includes a third piston chamber, and the fourth flow channel includes a fourth piston chamber; Provide a first piston rod and a second piston rod. The first piston rod includes a first piston head, a first connecting rod, and a second piston head arranged in sequence. The second piston rod includes a third piston head, a second connecting rod, and a fourth piston head arranged in sequence; The first piston rod is movably connected to the first housing and the second housing. At least part of the first piston head is located in the first piston chamber, and at least part of the second piston head is located in the third piston chamber; The second piston rod is movably connected to the first housing and the second housing. At least part of the third piston head is located in the second piston chamber, and at least part of the fourth piston head is located in the fourth piston chamber.

12. The manufacturing method of the perfusion device according to claim 11, characterized in that, Further comprising: Provide a driving mechanism and connect the driving mechanism to the first piston rod and the second piston rod.

13. The manufacturing method of the perfusion device according to claim 11, characterized in that, Further comprising: Provide a third housing, the third housing is integrally formed by injection molding. The third housing encloses a fifth flow channel, a sixth flow channel, a seventh flow channel, and an eighth flow channel; Connect the first housing, the second housing, and the third housing. The first housing and the second housing are located at both ends of the third housing in a first direction.

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