Liquid insecticide containing emamectin benzoate and application

Abstract

The invention relates to the field of agricultural insecticides, in particular to a liquid insecticide containing emamectin benzoate and application. The emamectin benzoate-containing liquid insecticide comprises an emamectin benzoate-containing insecticidal active component, an auxiliary agent and a solvent, wherein the auxiliary agent in the liquid insecticide contains a stabilizer; wherein the stabilizer accounts for 0.1-20% of the weight of the liquid insecticide. The problems that the decomposition rate of an emamectin benzoate missible oil mixture is unqualified after heat storage and emulsion is demulsified under the condition of flight prevention medication are solved, waste of pesticide in the diluting and spraying process is avoided, the utilization rate of the pesticide is increased, and meanwhile normal exertion of the pesticide effect of the pesticide is guaranteed.

Description

Technical Field

[0001] The present invention relates to the field of agricultural insecticides, and particularly to a liquid insecticide containing emamectin benzoate and its application. Background Art

[0002] Emamectin benzoate (full name: emamectin benzoate), white or light yellow crystalline powder, soluble in acetone and methanol, slightly soluble in water, insoluble in hexane. It is a new type of highly efficient semi-synthetic antibiotic insecticide synthesized from the fermentation product avermectin B1. It has the characteristics of ultra-high efficiency, low toxicity (the preparation is nearly non-toxic), low residue, and pollution-free of biological pesticides, and is widely used for the control of various pests on crops such as vegetables, fruit trees, and cotton.

[0003] Emamectin benzoate is easily decomposed. Affected by factors such as too high or too low acidity and light, emamectin benzoate is easily decomposed.

[0004] Neonicotinoid pesticides are a new type of insecticides following organophosphorus, carbamate, and pyrethroid insecticides. At present, they have become the mainstream products for controlling piercing-sucking mouthpart pests. Although their resistance and bee toxicity problems still need attention, there is no alternative product for their control effect in a short time.

[0005] Acetamiprid has stomach toxicity, contact toxicity, and strong penetration. It has quick efficacy and a long residual period, and also has certain acaricidal activity. Its action mode is a systemic insecticide for soil and branches and leaves, and is widely used for the control of aphids, planthoppers, thrips, and some Lepidoptera pests on rice, especially vegetables, fruit trees, and tea. It is also effective against pests that have developed resistance to organophosphorus, pyrethroid, and carbamate pesticides, and is one of the ideal substitutes for highly toxic organophosphorus pesticides.

[0006] Flupyradifurone belongs to the butenoate insecticides, with contact toxicity, stomach toxicity, and penetration. It can be used for foliar spraying, soil treatment, or seed treatment. It has many applicable crops and is widely used for vegetables, potatoes, cucumbers, watermelons, fruit trees, coffee, cocoa, cotton, soybeans (seed treatment), and other field crops, etc., to highly selectively control major piercing-sucking mouthpart pests, such as aphids, whiteflies, psyllids, leafhoppers, scale insects, beetles, leaf miners, mealybugs, soft scales, citrus psyllids, weevils, and thrips, etc., and is effective against pests in all growth stages, including larvae and adults.

[0007] Thiametoxam is a ryanodine receptor modulator. This type of insecticide binds to the ryanodine receptor, opens the calcium ion channel, and causes the continuous release of calcium ions in the cell into the sarcoplasm. The calcium ions combine with the matrix proteins in the sarcoplasm, causing continuous muscle contraction. As a result, the target pests exhibit symptoms such as twitching, paralysis, and antifeeding, and eventually die. Thiametoxam has better insecticidal activity or field control efficacy against Lepidoptera pests such as Cnaphalocrocis medinalis, Chilo suppressalis, Sesamia inferens, Plutella xylostella, Pieris rapae, Spodoptera litura, Spodoptera exigua, Mythimna separata, Helicoverpa armigera, and Ostrinia furnacalis than chlorantraniliprole or is comparable to it. At low concentrations, thiametoxam still has excellent control efficacy against Spodoptera exigua.

[0008] Patent CN105145621A discloses a drug for controlling tobacco aphids, which is characterized in that the active ingredients are: acetamiprid, imidacloprid, tebuconazole, beta-cypermethrin, matrine, methidathion, nitenpyram, emamectin benzoate, pymetrozine, and the weight ratio of the active ingredients is 3 - 5:2 - 6:1 - 4:5 - 9:4 - 7:1 - 3:2 - 5:4 - 7:6 - 10. The active ingredients are made into wettable powders, water dispersible granules, and wettable emulsions by adding carriers.

[0009] Patent CN104621170A discloses a mixed soluble granule insecticide of acetamiprid and emamectin benzoate and its preparation method.

[0010] Patent CN102550586A discloses a special drug for aerial spraying composed of a binary composition of emamectin benzoate and acetamiprid. It is characterized in that the dosage form is a suspension, a wettable powder, or a microemulsion.

[0011] Patent CN105010378A discloses an insecticidal composition containing acetamiprid and emamectin benzoate and its application, which is characterized in that: it includes drug active ingredients and synergistic adjuvants, the drug active ingredients are acetamiprid and emamectin benzoate, the weight ratio of acetamiprid and emamectin benzoate is 1 - 90:1 - 90, and the synergistic adjuvant is a foliar fertilizer, and the dosage form is a water dispersible granule, a suspension, or a wettable powder.

[0012] Patent CN102113505A discloses a composition for controlling Brontispa longissima containing acetamiprid. It is characterized in that: the composition for controlling Brontispa longissima containing acetamiprid can be made into different application dosage forms, including wettable powders, soluble powders, and water dispersible granules.

[0013] Patent CN103651426A discloses a pesticidal composition containing flupyradifurone and biogenic substances. It is characterized in that: a pesticidal composition containing active ingredient A and active ingredient B, where active ingredient A is selected from flupyradifurone, and active ingredient B is selected from any one of the following compounds: abamectin, spinosad, emamectin benzoate, spinetoram, and the composition is made into wettable powder, water dispersible granule, suspension concentrate, suspo-emulsion, emulsion in water, microemulsion, microcapsule suspension, suspension concentrate.

[0014] The article "Screening and Application of the Compound Formulation of Chlorantraniliprole against Plutella xylostella" uses the leaf dipping method to screen the synergistic effects of chlorantraniliprole and emamectin benzoate in different ratios, and determines that the ratios of 14:1 and 19:1 are synergistic. It does not directly mention the preparation of emulsifiable concentrate and solve the problems of emamectin benzoate decomposition and unqualified emulsion stability.

[0015] There is no report on the qualified thermal storage decomposition rate and qualified emulsion stability under the dilution conditions for aerial spraying when emamectin benzoate is mixed with acetamiprid, emamectin benzoate is mixed with flupyradifurone, and emamectin benzoate is mixed with chlorantraniliprole to prepare emulsifiable concentrate.

[0016] Thus, when preparing an emulsifiable concentrate mixture containing emamectin benzoate compound A using conventional methods and auxiliaries, the decomposition rate of emamectin benzoate is unqualified (the decomposition rate after thermal storage is greater than 5%), and the emulsion stability is unqualified under the dilution conditions of 20-fold dilution with 1000 ppm 5°C hard water (the dilution conditions for aerial spraying). Along with the demulsification of the diluted emulsion, the application performance of the liquid medicine is greatly affected, and the drug efficacy cannot be guaranteed. This phenomenon seriously affects the normal use of the liquid medicine in the field of aerial spraying, significantly affects the drug efficacy, and even leads to unusability. Summary of the Invention

[0017] The purpose of the present invention is to disclose a liquid insecticide containing emamectin benzoate and its application.

[0018] To achieve the above purpose, the technical solution of the present invention is as follows:

[0019] A liquid insecticide containing emamectin benzoate, an insecticidal active ingredient containing emamectin benzoate, auxiliaries and a solvent, wherein the auxiliaries in the liquid insecticide contain a stabilizer; among them, the stabilizer accounts for 0.1-20% of the weight of the liquid insecticide.

[0020] The stabilizer is selected from picroside I or picroside II.

[0021] The insecticidal active ingredient is emamectin benzoate and compound A; among them, compound A is selected from acetamiprid (A1), flupyradifurone (A2) or chlorantraniliprole (A3), emamectin benzoate accounts for 1-10% of the weight of the liquid insecticide, and compound A accounts for 1-10% of the weight of the liquid insecticide.

[0022] The liquid dosage form is emulsifiable concentrate.

[0023] The auxiliary agent is an emulsifier.

[0024] The emulsifier is selected from one or more of nonylphenol polyoxyethylene ether, calcium dodecylbenzenesulfonate, ethoxylated triphenylethylene phenol phosphate, polyoxyethylene aryl ether, fatty alcohol polyoxyethylene ether, ammonium polyoxyethylene aryl phenyl ether phosphate, emulsifier 500#, emulsifier 600#, emulsifier 0201B, emulsifier 0203B, emulsifier 1601, emulsifier 1602, emulsifier AEO3, emulsifier T80, emulsifier T20, emulsifier S80.

[0025] The solvent is selected from one or more of SV17, SV33, SV92, ADMA10, DIB, Polarclean, Green25, solvent oil S150, solvent oil S200, N,N-dimethylformamide, N,N-dimethylacetamide, methanol, ethanol, isooctanol, mineral oil, triethyl phosphate, propylene glycol phenyl ether.

[0026] An application of the liquid insecticide containing emamectin benzoate as described above, the application of the liquid insecticide as an agricultural insecticide.

[0027] The preparation is applied to the pests to be controlled or their growth medium at 10 - 100 g of active ingredient per hectare.

[0028] Advantages of the present invention:

[0029] The present invention adds a specific amount of picroside I or picroside II as a stabilizer. Picroside I or picroside II has a specific special spatial configuration and charge effect brought by its own molecular structure, making it have a dual effect. When combined with emamectin benzoate, due to the charge effect of its molecular structure, it can play a certain antioxidant role to protect emamectin benzoate, so that the decomposition rate of emamectin benzoate after heat storage (54°C for 14 days) is qualified (less than 5%). At the same time, due to the special spatial configuration of its own polyhydroxy aromatic hydrocarbon structure, it is attracted to emamectin benzoate and compound A by polarity and provides a certain steric hindrance, avoiding the emulsion breaking phenomenon of the effective ingredient during the dilution process at a small dilution multiple due to its own electronegativity, and ensuring that the emulsion stability of the emulsifiable concentrate is qualified under the condition of 20-fold dilution with 1000 ppm 5°C hard water (the dilution condition for aerial spraying).

[0030] The qualified heat storage decomposition rate and good emulsion stability ensure the application performance of the emulsifiable concentrate and play an important role in the exertion of the preparation efficacy.

[0031] The emulsifiable concentrate prepared by the technical scheme of the present invention solves the problems of unqualified decomposition rate of emamectin benzoate after heat storage and emulsion breaking under the conditions of aerial spraying, avoids the waste of pesticides during the dilution and spraying process, improves the pesticide utilization rate, and ensures the normal exertion of the pesticide efficacy.

[0032] Meanwhile, during the shelf life of the insecticide containing stabilizer of the present invention, the masses of the two active components are stable, the additive will not cause the decomposition of Compound A, and no obvious physical or chemical changes will occur to the preparation. Specific embodiments

[0033] The present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited to these embodiments. As is well known to those skilled in the art, the present invention covers all alternative solutions, improvement solutions and equivalent solutions that may be included within the scope of the claims. The technical drugs and other materials in the embodiments are all commercially available.

[0034] Determination method of thermal storage decomposition rate

[0035] The determination method of the thermal storage decomposition rate of emamectin benzoate refers to the national standard of the People's Republic of China GB / T20693-2020 Propargite technical.

[0036] Test method for emulsion stability

[0037] Pour out the whole bottle of the product and mix it evenly. Weigh an appropriate amount of the sample accurately to 0.0002 g. Place it in a graduated cylinder containing 95 mL of hard water at a temperature of ±2 °C, cover the stopper, and with the middle of the graduated cylinder as the axis, invert the graduated cylinder 30 times up and down within 1 minute. Then place it vertically in a constant temperature water bath without vibration (the water bath temperature is the same as the hard water temperature), avoid direct sunlight, and place it for 24 hours to observe whether the emulsion breaks.

[0038] Example 1 11% Emamectin benzoate·acetamiprid (Compound A1) EC

[0039] According to the weight percentage formula requirements, emamectin benzoate is 1%, acetamiprid is 10%, the stabilizer picroside I is 0.1%, emulsifier 500# is 10%, emulsifier 600# is 12%, SV17 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0040] Control Example 1 11% Emamectin benzoate·acetamiprid (Compound A1) EC

[0041] According to the weight percentage formula requirements, emamectin benzoate is 1%, acetamiprid is 10%, emulsifier 500# is 10%, emulsifier 600# is 12%, SV17 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0042] Example 2 10% Emamectin benzoate·acetamiprid (Compound A1) EC

[0043] According to the formula requirements by weight percentage, emamectin benzoate is 2%, acetamiprid is 8%, the stabilizer picroside II is 8%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0044] Control Example 2: 10% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0045] According to the formula requirements by weight percentage, emamectin benzoate is 2%, acetamiprid is 8%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0046] Example 3: 12% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0047] According to the formula requirements by weight percentage, emamectin benzoate is 6%, acetamiprid is 6%, the stabilizer picroside I is 5%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0048] Control Example 3: 12% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0049] According to the formula requirements by weight percentage, emamectin benzoate is 6%, acetamiprid is 6%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0050] Example 4: 13% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0051] According to the formula requirements by weight percentage, emamectin benzoate is 7%, acetamiprid is 6%, the stabilizer picroside II is 3%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, ADMA10 is 20%, and S200 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0052] Control Example 4: 13% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0053] According to the formulation requirements by weight percentage, emamectin benzoate is 7%, acetamiprid is 6%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, ADMA10 is 20%, and S200 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0054] Example 5 10% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0055] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, acetamiprid is 1%, picroside I as the stabilizer is 10%, ethoxytriphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, DIB is 20%, and N,N-dimethylformamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0056] Control Example 5 10% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0057] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, acetamiprid is 1%, ethoxytriphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, DIB is 20%, and N,N-dimethylformamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0058] Example 6 18% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0059] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, acetamiprid is 9%, picroside II as the stabilizer is 9%, fatty alcohol polyoxyethylene ether is 15%, ammonium salt of polyoxyethylene arylphenyl ether phosphate is 10%, Green25 is 20%, and N,N-dimethylhexamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0060] Control Example 6 18% Emamectin Benzoate·Acetamiprid (Compound A1) Emulsifiable Concentrate

[0061] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, acetamiprid is 9%, fatty alcohol polyoxyethylene ether is 15%, ammonium salt of polyoxyethylene arylphenyl ether phosphate is 10%, Green25 is 20%, and N,N-dimethylhexamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0062] Example 7 12% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0063] According to the formula requirements by weight percentage, emamectin benzoate is 2%, flupyradifurone is 10%, the stabilizer picroside I is 0.1%, emulsifier 500# is 10%, emulsifier 600# is 12%, propylene glycol phenyl ether is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0064] Control Example 7: 12% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0065] According to the formula requirements by weight percentage, emamectin benzoate is 2%, flupyradifurone is 10%, emulsifier 500# is 10%, emulsifier 600# is 12%, propylene glycol phenyl ether is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0066] Example 8: 11% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0067] According to the formula requirements by weight percentage, emamectin benzoate is 3%, flupyradifurone is 8%, the stabilizer picroside II is 8%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate. Control Example 8: 11% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0068] According to the formula requirements by weight percentage, emamectin benzoate is 3%, flupyradifurone is 8%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0069] Example 9: 13% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0070] According to the formula requirements by weight percentage, emamectin benzoate is 6%, flupyradifurone is 7%, the stabilizer picroside I is 5%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and isooctanol is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0071] Control Example 9: 13% Emamectin Benzoate·Flupyradifurone (Compound A2) Emulsifiable Concentrate

[0072] According to the formula requirements by weight percentage, emamectin benzoate is 6%, flupyradifurone is 7%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and isooctanol is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0073] Example 10 14% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0074] According to the formulation requirements by weight percentage, emamectin benzoate is 7%, flupyradifurone is 7%, the stabilizer picroside II is 3%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, mineral oil is 20%, and S200 is added to make up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0075] Control Example 10 14% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0076] According to the formulation requirements by weight percentage, emamectin benzoate is 7%, flupyradifurone is 7%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, mineral oil is 20%, and S200 is added to make up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0077] Example 11 11% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0078] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, flupyradifurone is 2%, the stabilizer picroside I is 10%, ethoxytriphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, methanol is 20%, and N,N-dimethylformamide is added to make up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0079] Control Example 11 11% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0080] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, flupyradifurone is 2%, ethoxytriphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, methanol is 20%, and N,N-dimethylformamide is added to make up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0081] Example 12 18% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0082] According to the formulation requirements by weight percentage, emamectin benzoate is 9%, flupyradifurone is 9%, the stabilizer picroside II is 9%, fatty alcohol polyoxyethylene ether is 15%, ammonium salt of polyoxyethylene aryl phenyl ether phosphate is 10%, ethanol is 20%, and N,N-dimethylhexamide is added to make up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the EC.

[0083] Control Example 12 18% Emamectin Benzoate·Flupyradifurone (Compound A2) EC

[0084] According to the formula requirements by weight percentage, emamectin benzoate is 9%, flupyradifurone is 9%, fatty alcohol polyoxyethylene ether is 15%, ammonium polyoxyethylene aryl phenyl ether phosphate is 10%, ethanol is 20%, and N,N-dimethylhexamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0085] Example 13: 9% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0086] According to the formula requirements by weight percentage, emamectin benzoate is 1%, thiamethoxam is 8%, the stabilizer picroside I is 0.1%, emulsifier 500# is 10%, emulsifier 600# is 12%, SV17 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0087] Control Example 13: 9% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0088] According to the formula requirements by weight percentage, emamectin benzoate is 1%, thiamethoxam is 8%, emulsifier 500# is 10%, emulsifier 600# is 12%, SV17 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0089] Example 14: 8% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0090] According to the formula requirements by weight percentage, emamectin benzoate is 2%, thiamethoxam is 6%, the stabilizer picroside II is 8%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate. Control Example 14: 8% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0091] According to the formula requirements by weight percentage, emamectin benzoate is 2%, thiamethoxam is 6%, emulsifier 0201B is 10%, emulsifier 0203B is 12%, SV33 is 20%, and S150 is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0092] Example 15: 10% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0093] According to the formula requirements by weight percentage, emamectin benzoate is 5%, thiamethoxam is 5%, the stabilizer picroside I is 5%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and S150 is added up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0094] Control Example 15: 10% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0095] According to the formula requirements by weight percentage, emamectin benzoate is 5%, thiamethoxam is 5%, emulsifier T80 is 10%, emulsifier S80 is 12%, SV92 is 20%, and S150 is added up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0096] Example 16: 11% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0097] According to the formula requirements by weight percentage, emamectin benzoate is 5%, thiamethoxam is 6%, the stabilizer picroside II is 3%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, ADMA10 is 20%, and S200 is added up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0098] Control Example 16: 11% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0099] According to the formula requirements by weight percentage, emamectin benzoate is 5%, thiamethoxam is 6%, nonylphenol polyoxyethylene ether is 15%, calcium dodecylbenzenesulfonate S80 is 10%, ADMA10 is 20%, and S200 is added up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0100] Example 17: 7% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0101] According to the formula requirements by weight percentage, emamectin benzoate is 6%, thiamethoxam is 1%, the stabilizer picroside I is 10%, ethoxylated triphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, DIB is 20%, and N,N-dimethylformamide is added up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain the emulsifiable concentrate.

[0102] Control Example 17: 7% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0103] According to the formulation requirements by weight percentage, emamectin benzoate is 6%, thiamethoxam is 1%, ethoxytriphenylethylene phenol phosphate is 15%, polyoxyethylene aryl ether is 10%, DIB is 20%, and N,N-dimethylformamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain an emulsifiable concentrate.

[0104] Example 18 16% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0105] According to the formulation requirements by weight percentage, emamectin benzoate is 8%, thiamethoxam is 8%, the stabilizer picroside II is 9%, fatty alcohol polyoxyethylene ether is 15%, ammonium polyoxyethylene aryl phenyl ether phosphate is 10%, Green25 is 20%, and N,N-dimethylhexamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain an emulsifiable concentrate.

[0106] Control Example 18 16% Emamectin Benzoate·Thiamethoxam (Compound A3) Emulsifiable Concentrate

[0107] According to the formulation requirements by weight percentage, emamectin benzoate is 8%, thiamethoxam is 8%, fatty alcohol polyoxyethylene ether is 15%, ammonium polyoxyethylene aryl phenyl ether phosphate is 10%, Green25 is 20%, and N,N-dimethylhexamide is made up to 100%. Add the above materials into a beaker and mix evenly with mechanical stirring to obtain an emulsifiable concentrate.

[0108] Measure the thermal storage decomposition rate and emulsion stability of the above examples and control examples, as shown in Table 1.

[0109] Table 1. Thermal storage decomposition rate and emulsion stability of emamectin benzoate in emamectin benzoate·Compound A emulsifiable concentrate

[0110]

[0111]

[0112] It can be seen from Table 1 that for the examples with the added stabilizer, the decomposition rate of emamectin benzoate in the emulsifiable concentrate after thermal storage is less than 5%, within the qualified range, and at the same time, the emulsion stability of the emulsifiable concentrate is qualified. For the control examples without the added stabilizer, the decomposition rate of emamectin benzoate in the emulsifiable concentrate is far greater than 5%, not within the qualified range, and the emulsion stability of the corresponding emulsifiable concentrate is unqualified.

[0113] Based on the above examples and control examples, it can be seen that for the liquid insecticide containing emamectin benzoate obtained by the present invention, under the matching of specific stabilizers and auxiliaries, the thermal storage decomposition rate of emamectin benzoate is less than 5%, qualified, and the emulsion stability of the emulsifiable concentrate is qualified. It avoids the waste of pesticides during the dilution and spraying process, improves the utilization rate of pesticides, and ensures the normal exertion of pesticide efficacy.

[0114] Biological Activity Examples

[0115] Meanwhile, the liquid insecticide containing emamectin benzoate obtained from the above-mentioned examples was used to conduct indoor bioactivity assays; and a composition of emamectin benzoate technical + acetamiprid technical was used as a control.

[0116] Weigh the test agents accurately with an electronic analytical balance. For the formulated products, directly add water to prepare the stock solution with the required concentration. For the technical agents, first dissolve them completely with acetone, and then prepare the stock solution with the required concentration using 0.1% Tween 80 water. Dilute them with water or Tween water according to the test design dose to form a series of liquid medicines with a certain concentration gradient.

[0117] Indoor bioactivity assay method for Myzus persicae: Use the airbrush spraying method. Cut the cabbage leaves with appropriate size and infested with about 30 Myzus persicae from the cabbage plants cultured with Myzus persicae, remove the winged aphids and the aphids on the front side, place the leaves with the back side up in a petri dish for standby. According to the order of the test design dose from low to high, use the airbrush to spray evenly on both sides of the leaves. After the leaf surface is naturally air-dried, move it to a standard observation room (23 - 25°C, RH 40 - 60%, L / D is 13h / 11h), observe regularly, repeat the test 3 times, and set a blank control.

[0118] The treated test materials are placed in the observation room. The Myzus persicae are investigated 48 hours after treatment, record the number of dead and live insects, calculate the corrected mortality rate using the Abbott formula, and use DPS software to obtain the toxicity regression line and LC50 value.

[0119] Table 2 Indoor bioactivity assay results of the liquid insecticide against Myzus persicae

[0120]

[0121] It can be seen from Table 2 that the LC50 of Example 3 is equivalent to that of 6% emamectin benzoate + 6% acetamiprid technical, indicating that for the liquid insecticide prepared by the method of the present invention, its insecticidal activity is not affected by the addition of the stabilizer, and the activity of the liquid insecticide after adding the stabilizer is equivalent to that of the technical agent.

[0122] It can be seen from Table 2 that the LC50 of Comparative Example 3 is higher than that of Example 3, indicating that for the liquid insecticide sample prepared without adding the stabilizer, due to its poor emulsion stability when diluted with water and applied, its drug efficacy is poorly exerted, and its drug efficacy is significantly worse than that of Example 3 prepared by the present invention.

[0123] Therefore, for the liquid insecticide prepared by the present invention, only under the good condition of the synergistic action of the stabilizer and the adjuvant system can the drug efficacy be ensured, and the disadvantages brought by formulating the composition into a conventional emulsifiable concentrate can be avoided (the thermal storage decomposition rate of emamectin benzoate is unqualified and the emulsion stability is unqualified under the condition of 20-fold dilution with 1000 ppm 5°C hard water), and good storage stability and emulsion stability play an important role in the exertion of the drug efficacy of the formulation.

[0124] The liquid preparation prepared according to the present patent and applicable in agriculture has a control scope for crops far beyond the green peach aphid on kidney beans mentioned in the above embodiments. According to the records in the published literature of emamectin benzoate and Compound A, it can be inferred that this liquid insecticide has positive control effects on Helicoverpa armigera, Spodoptera exigua, Spodoptera depravata, Heliothis assulta, Aphis gossypii, Brevicoryne brassicae, Carposina sasakii, planthoppers, thrips, etc.

Claims

1. A liquid insecticide containing emamectin benzoate, comprising an insecticidal active ingredient containing emamectin benzoate, an auxiliary agent and a solvent, characterized in that: The auxiliary agent in the liquid insecticide contains a stabilizer; wherein, the stabilizer accounts for 0.1-20% of the weight of the liquid insecticide.

2. The liquid insecticide containing emamectin benzoate according to claim 1, characterized in that: The stabilizer is selected from picroside I or picroside II.

3. The liquid insecticide containing emamectin benzoate according to claim 1, wherein: The insecticidal active ingredient is emamectin benzoate and compound A; wherein, compound A is selected from acetamiprid (A1), flupyradifurone (A2) or thiodicarb (A3), emamectin benzoate accounts for 1-10% of the weight of the liquid insecticide, and compound A accounts for 1-10% of the weight of the liquid insecticide.

4. The liquid insecticide containing emamectin benzoate according to claim 1, wherein: The liquid dosage form is an emulsifiable concentrate.

5. The liquid insecticide containing emamectin benzoate according to any one of claims 1-4, characterized in that: The auxiliary agent is an emulsifier.

6. The liquid insecticide containing emamectin benzoate according to claim 5, wherein: The emulsifier is selected from one or more of nonylphenol polyoxyethylene ether, calcium dodecylbenzenesulfonate, ethoxylated triphenylethylene phenol phosphate, polyoxyethylene aryl ether, fatty alcohol polyoxyethylene ether, ammonium polyoxyethylene aryl phenyl ether phosphate, emulsifier 500#, emulsifier 600#, emulsifier 0201B, emulsifier 0203B, emulsifier 1601, emulsifier 1602, emulsifier AEO3, emulsifier T80, emulsifier T20, emulsifier S80.

7. The emamectin benzoate-containing liquid insecticide according to claim 1 or 4, characterized in that: The solvent is selected from one or more of SV17, SV33, SV92, ADMA10, DIB, Polarclean, Green25, solvent oil S150, solvent oil S200, N,N-dimethylformamide, N,N-dimethylacetamide, methanol, ethanol, isooctanol, mineral oil, triethyl phosphate, propylene glycol phenyl ether.

8. Use of the emamectin benzoate-containing liquid insecticide according to claim 1, characterized in that: The application of the liquid insecticide as an agricultural insecticide.

9. Use of the emamectin benzoate-containing liquid insecticide according to claim 8, characterized in that: The preparation is applied at 10-100 g of active ingredient per hectare to the pests to be controlled or their growth medium.

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