Oil control composition and application thereof

Abstract

The invention discloses an oil control composition and application thereof. The oil control composition comprises an auxiliary material and a hydrogel microcapsule serving as an active component, wherein the hydrogel microcapsule is provided with a wall material and a core material of hydrogel; the core material is formed by dispersing an amphiphilic substance and an oil control component into a homogeneous phase according to the weight ratio of (2.2-8.7): 1. The oil control composition provided by the invention has a relatively high oil control effect and has relatively high mildness.

Description

Technical Field

[0001] This application relates to the technical field of skin care products, and particularly to an oil-control composition and its application. Background Art

[0002] Oily skin usually shows excessive sebum secretion on the skin surface. The reasons for its occurrence are mainly related to genetic factors, endocrine homeostasis, environmental factors, daily care and other factors. Under normal circumstances, the sebum secreted by the sebaceous glands maintains the moisture and integrity of the skin. However, excessive oil not only makes the skin look greasy, but also easily leads to pore blockage, causing skin problems such as acne, blackheads, and comedones. In addition, oily skin may also be accompanied by a weakened skin barrier function, increasing skin sensitivity and the risk of infection.

[0003] In related technologies, some oil-control compositions reduce oiliness by using oil-control products such as facial cleansers, toners, and lotions to clean or adjust the oil balance on the skin surface. Some oil-control compositions contain a large amount of chemical additives, which have a quick effect but a greater burden on the skin. Long-term use may damage the skin barrier and cause other skin problems. Some products mainly use relatively mild ingredients such as plant extracts, which have a slow effect and require long-term use, and the effects vary from person to person, unable to meet the usage requirements.

[0004] Based on this, how to develop a product that can balance the oil-control effect and mildness has been the direction that the field has been working on improving. Summary of the Invention

[0005]

Problems to be Solved

[0006] This application aims to solve at least one of the technical problems existing in the prior art. For this reason, one object of this application is to provide an oil-control composition and its application to better balance the oil-control effect and mildness.

[0007]

Means for Solving the Problems

[0008] The inventors of the present invention have conducted repeated in-depth research to solve the above problems and realized that a single oil control method is difficult to balance the oil control effect and mildness better. Based on this awareness, it was creatively discovered that the hydrogel wall material of the hydrogel microcapsules is hydrophilic and can be effectively spread on the skin surface. The porous structure can effectively adsorb target removal substances such as oil in the skin after spreading on the skin surface; the amphiphilic substances contained in the core material of the hydrogel microcapsules use their hydrophilicity and / or lipophilicity to capture the target removal substances adsorbed through the porous structure. In the core material formed by dispersing the amphiphilic substance and the oil control component into a homogeneous phase, the oil control component can be connected to the amphiphilic substance at least through physical action, so that the oil control component exerts an oil control effect on the target removal substances captured by the amphiphilic substance, and then completes the removal path of transferring the target removal substances to the outside of the skin and removing them. Since this method depends on a specific removal effect of transferring the target substance to the outside of the skin rather than a removal effect of penetrating into the skin, the oil control effect is improved and the skin irritation is reduced. Thus, the present invention was completed.

[0009] On the one hand, the present application provides an oil control composition, comprising excipients and hydrogel microcapsules as active components;

[0010] Among them, the hydrogel microcapsules have a hydrogel wall material and a core material; the core material is formed by dispersing an amphiphilic substance and an oil control component into a homogeneous phase at a weight ratio of 2.2-8.7:1.

[0011] In any embodiment, the oil control component is at least one of salicylic acid, salicylic acid ester, tea tree essential oil, centella asiatica extract, hypericum perforatum extract, witch hazel extract, honey extract, hyperin.

[0012] In any embodiment, the HLB value of the amphiphilic substance is 7-30.

[0013] In any embodiment, the amphiphilic substance is at least one of polysorbate, sodium lauroyl sarcosinate, cocamidopropyl betaine, glyceryl stearate, lecithin, PEG-40 hydrogenated castor oil.

[0014] In any embodiment, the average particle size of the hydrogel microcapsules is 30-300 microns.

[0015] In any embodiment, the porosity of the hydrogel microcapsules is 50-80%.

[0016] In any embodiment, the solvent of the core material is water or C1-4 alcohol.

[0017] In any embodiment, the wall material of the capsule is at least one of agar, konjac gum, chitosan, locust bean gum, guar gum and its derivatives, methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20, and glycerol polyacrylate.

[0018] In any embodiment, the mass dosage of the core material of the hydrogel microcapsule is 3-12% based on the total mass of the hydrogel microcapsule.

[0019] On the other hand, the present application provides an application of the above-mentioned oil-control composition, and the oil-control composition is applied to cream, lotion, and aqueous products.

[0020]

Invention Effect

[0021] The oil-control composition provided by the present application has a high oil-control effect and higher mildness. Specific Embodiments

[0022] Hereinafter, the embodiments of the present application will be specifically described in detail. However, there may be cases where unnecessary details are omitted. For example, there may be cases where the detailed description of well-known matters and the repeated description of actually identical structures are omitted. This is to avoid the following description from becoming unnecessarily long and to facilitate the understanding of those skilled in the art. In addition, the following description is provided for those skilled in the art to fully understand the present application and is not intended to limit the subject matter recited in the claims. The "range" disclosed in the present application is defined in the form of a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundary of a specific range. The range defined in this way can include the end values or not include the end values, and can be combined arbitrarily, that is, any lower limit can be combined with any upper limit to form a range. For example, if ranges of 60-120 and 80-110 are listed for a specific parameter, ranges of 60-110 and 80-120 are also contemplated. In addition, if the minimum range values 1 and 2 are listed, and if the maximum range values 3, 4, and 5 are listed, then the following ranges are all contemplated: 1-3, 1-4, 1-5, 2-3, 2-4, and 2-5. In the present application, unless otherwise stated, the numerical range "a-b" represents an abbreviated representation of any real number combination between a and b, where a and b are both real numbers. For example, the numerical range "0-5" means that all real numbers between "0-5" have been fully listed herein, and "0-5" is only an abbreviated representation of these numerical combinations. In addition, when it is stated that a certain parameter is an integer ≥2, it is equivalent to disclosing that the parameter is, for example, the integer 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0023] Unless otherwise specified, all embodiments and optional embodiments of the present application can be combined with each other to form a new technical solution.

[0024] Unless otherwise specified, all technical features and optional technical features of the present application can be combined with each other to form a new technical solution.

[0025] Unless otherwise specified, all steps of the present application can be carried out sequentially or randomly, preferably sequentially. For example, the method includes steps (a) and (b), which means that the method can include steps (a) and (b) carried out sequentially, or can also include steps (b) and (a) carried out sequentially. For example, it is mentioned that the method may further include step (c), which means that step (c) can be added to the method in any order. For example, the method can include steps (a), (b) and (c), or can also include steps (a), (c) and (b), or can also include steps (c), (a) and (b), etc.

[0026] Unless otherwise specified, the terms "comprising" and "including" mentioned in the present application mean open-ended or can also be closed-ended. For example, the "comprising" and "including" can mean that other components not listed can also be included or contained, or can also only include or contain the listed components.

[0027] Unless otherwise specified, in the present application, the term "or" is inclusive. For example, the phrase "A or B" means "A, B, or both A and B". More specifically, any of the following conditions satisfies the condition "A or B": A is true (or exists) and B is false (or does not exist); A is false (or does not exist) while B is true (or exists); or both A and B are true (or exist).

[0028]

Oil-control composition

[0029] The specifically disclosed oil-control composition of the present application comprises excipients and hydrogel microcapsules as active components;

[0030] Among them, the hydrogel microcapsules have a hydrogel wall material and a core material; the core material is formed by uniformly dispersing amphiphilic substances and oil-control components in a weight ratio of 2.2 - 8.7:1.

[0031] As the auxiliary materials for the application, conventional auxiliary materials used in similar fields such as cosmetics and skin care products can be adopted. By way of example, oily solvents typical of oil-based essences or emulsions, such as mineral oil (light / heavy), vegetable oil (jojoba oil, rosehip oil), silicone oil (such as cyclopentasiloxane); humectants typical of glycerol, propylene glycol, sorbitol, petrolatum, lanolin, ceramide, hyaluronic acid (hyaluronic acid), carboxymethyl cellulose, etc.; thickeners typical of Carbomer (gel matrix), xanthan gum, aloe vera gel, sodium alginate, talc powder (to improve smoothness), silica; pH regulators typical of citric acid, lactic acid, malic acid, triethanolamine, ammonia water; antioxidants typical of vitamin C (ascorbic acid), vitamin E (tocopherol), rosemary extract, asiaticoside; pigments typical of iron oxide (red), titanium dioxide (white), CI 19140 (blue); and fragrances typical of phenoxyethanol, parabens (methyl ester, ethyl ester, etc.), octanoyl hydroxamic acid, tea tree oil (tea tree essential oil), grapefruit seed extract, nisin, etc.

[0032] In addition to the above, preservatives can be added according to the required product storage time as needed. Preservatives are fragrances typical of floral scents, fruit scents, and essential oils. The addition of preservatives is very limited within the scope of health and safety.

[0033] As for the specific addition amounts of the above auxiliaries, there is no special limitation, which is considered based on the actual needs of those skilled in the art for performance other than the purpose of this application (such as skin care, makeup, or facial cleansing) or safety in use, etc. As a relatively general limiting amount, the addition amount of the active component is 0.5 - 27% by weight based on the sum of the weights of the auxiliary materials and the active component.

[0034] Now, several conventional specific examples can be listed:

[0035] Example A: 1 - 15 parts of active component (hydrogel microcapsules), 1 - 15 parts of humectant, 5 - 10 parts of emulsifier, 5 - 20 parts of emollient oil, 0.1 - 2 parts of thickener, 40 - 95 parts of water, etc.;

[0036] Example B: 20.5 - 25.5% of active component, 10 - 14% of coconut oil amide propyl betaine foaming agent,

[0037] 5 - 8% of PEG - 7 glyceryl cocoate micelle former, 6 - 8% of butanediol (humidifying solvent), 0.3 - 0.5% of dipotassium glycyrrhizinate for anti - inflammation and soothing, 0.1 - 0.3% of sodium citrate pH regulator (to 5.5 - 6.5), 0.8 - 1.2% of sodium chloride (for thickening and stabilizing), 0.02 - 0.06% of fragrance, 0.03 - 0.05% of preservative (such as phenoxyethanol + methylisothiazolinone);

[0038] Example C: Active ingredient 5.5 - 7.3%, deionized water: 60 - 65% (base solvent), ethanol: 5 - 8% (penetration enhancer, removing grease), dipotassium glycyrrhizinate (soothing sensitive skin) 0.2 - 0.3%, PEG - 40 hydrogenated castor oil (emulsifying / solubilizing) 0.5 - 0.8%, octanoyl glycine (oil control and antioxidant) 0.3 - 0.5%, pH regulator (such as citric acid) to maintain pH 4.0 - 4.5, preservative (such as phenoxyethanol): 0.6 - 0.8% (tolerant preservative system);

[0039] Example D: Active ingredient 2 - 3%, caprylic / capric triglyceride 15 - 20% (penetration enhancer and anti - inflammatory), cyclopentasiloxane (film - forming agent) 5 - 8%, PEG - 40 hydrogenated castor oil (emulsifier) 3 - 5%, butylene glycol (moisturizing solvent) 8 - 10%, witch hazel extract (natural astringent) 1 - 2%, carbomer resin (thickening) 0.2 - 0.4%, triethanolamine (adjusting pH to 5.0 - 5.5) 0.3 - 0.5%, preservative (such as potassium sorbate + phenoxyethanol) 0.7 - 0.9% (compound preservation), essence: 0.01 - 0.04% (trace flavoring).

[0040]

Hydrogel Microcapsules

[0041] Those skilled in the art are aware of the ways to obtain hydrogel microcapsules. It can be achieved through well - known physical encapsulation methods (Physical Encapsulation), chemical cross - linking methods (Chemical Crosslinking), microfluidics techniques (Microfluidics), self - assembly techniques (Self - Assembly), and template methods (Template Method).

[0042] Physical encapsulation methods (Physical Encapsulation) are divided into liposome / lipoid encapsulation and microsphere / microencapsulation techniques. Liposome / lipoid encapsulation means that the active ingredient is encapsulated in a hydrogel matrix through physical means, without relying on chemical cross - linking, mainly relying on intermolecular forces (such as hydrogen bonds, hydrophobic interactions) or mechanical isolation. The specific operation method can be exemplified as follows: The core material formed by dispersing amphiphilic substances and oil - controlling components into a homogeneous phase is dissolved in a lipophilic solvent (such as caprylic / capric triglyceride), and is mixed with the wall material (such as sodium hyaluronate aqueous solution) through ultrasonic treatment, and the aqueous phase is encapsulated by the bilayer structure of the liposome. The microsphere / microencapsulation technique is to encapsulate the active ingredient in polymer microspheres through the emulsion - solvent evaporation method (such as the W / O / W emulsion template method), and then mix it with the hydrogel.

[0043] The technical principle of the chemical cross-linking method is to form a three-dimensional network-structured hydrogel matrix through the cross-linking reaction of cross-linking agents (such as epoxy resins, aldehyde compounds) or natural polysaccharides, and "solidify" the active ingredients in the network. The specific operation method is as follows: Taking hyaluronic acid HA as the wall material as an example, the uncrosslinked hyaluronic acid HA reacts with a cross-linking agent (such as BDDE, Dextransulfoxyethyl) in a solvent to form a cross-linked HA hydrogel, and then the core material components formed by the homogeneous dispersion of amphiphilic substances and oil-control components are loaded by the impregnation method. Taking chitosan as the wall material as an example, the specific operation method is: cross-link chitosan with acrylate monomers by ionic bonds or covalent bonds to form a biodegradable hydrogel, and load the active ingredients by adsorption or covalent binding.

[0044] Microfluidic technology refers to precisely controlling fluid dynamics through a microfluidic chip to construct monodisperse and uniformly sized hydrogel microcapsules. The specific operation can be demonstrated as follows: Mix a hydrogel precursor (such as acrylamide solution) with an active ingredient solution in a microchannel, and initiate a polymerization reaction through ultraviolet light to generate microcapsules in real time.

[0045] Self-assembly technology refers to the spontaneous formation of a hydrogel structure based on molecular self-assembly (such as micelles, lipid raft structures) without external cross-linking agents through the interaction between components. The specific operation can be demonstrated as follows: Dissolve a copolymer containing a hydrophilic segment (such as PEG) and a hydrophobic segment (such as Pluronic F127) in water, and induce self-assembly into micelles through temperature or pH changes, using the core material formed by the homogeneous dispersion of amphiphilic substances and oil-control components.

[0046] The template method refers to using a porous template (such as a silica gel membrane, zeolite) as a "mold" to form a hydrogel matrix within the template, and obtaining a capsule structure after demolding. The specific operation can be demonstrated as follows: Inject the precursor of the wall material into a silica gel mold, take it out after cross-linking and curing, and obtain a hollow hydrogel capsule.

[0047] As a suitable but non-limiting specific example, the average particle size of the hydrogel microcapsules is 30 - 300 microns, specifically demonstrable as 32 - 300 microns, 35 - 300 microns, 40 - 300 microns, 45 - 300 microns, 50 - 300 microns, 60 - 300 microns, 65 - 300 microns, 70 - 300 microns, 80 - 300 microns, 90 - 300 microns, 100 - 300 microns, 110 - 300 microns, 120 - 300 microns, 150 - 300 microns, 170 - 300 microns, 190 - 300 microns, 210 - 300 microns, 220 - 300 microns, 230 - 300 microns, 250 - 300 microns, 270 - 300 microns, 280 - 300 microns, 290 - 300 microns, 30 - 290 microns, 30 - 280 microns, 30 - 270 microns, 30 - 260 microns, 30 - 250 microns, 30 - 220 microns, 30 - 200 microns, 30 - 190 microns, 30 - 170 microns, 30 - 150 microns, 30 - 130 microns, 30 - 110 microns, 30 - 90 microns, 30 - 80 microns, 30 - 70 microns, 30 - 60 microns, 30 - 55 microns, 30 - 40 microns, 30 - 35 microns, etc. This appropriate level of average particle size can balance the stability of the hydrogel microcapsules and the adsorption capacity for the target skin-removing substances.

[0048] It should be realized that the average particle size level of the hydrogel microcapsules can be adjusted by controlling the dropping rate and the crosslinking rate of the crosslinking agent. Generally speaking, the higher the dropping rate, the smaller the average particle size; the higher the crosslinking rate, the larger the average particle size, etc. And the crosslinking rate can be determined by the concentration and type of the crosslinking agent.

[0049] As a suitable but non-limiting specific example, the porosity of the hydrogel microcapsules is 50 - 80%, specifically demonstrable as 50 - 78%, 50 - 75%, 50 - 70%, 50 - 65%, 50 - 60%, 50 - 58%, 50 - 55%, 52 - 80%, 55 - 80%, 60 - 80%, 65 - 80%, 68 - 80%, 70 - 80%, 72 - 80%, 75 - 80%, 78 - 80%, etc. This appropriate level of porosity can obtain a more suitable adsorption capacity without particularly damaging the encapsulation of the core material.

[0050] It should be realized that the porosity level of the hydrogel microcapsules can be achieved by controlling the crosslinking agent concentration or the conventional adjustment of the water phase proportion. For example, reducing the crosslinking agent concentration makes the network structure sparser and retains more free water; a higher water phase proportion can directly increase the porosity by increasing the content of the hydrogel microcapsules.

[0051] As a suitable but non-limiting specific example, the mass dosage of the core material of the hydrogel microcapsule is 3-12% based on the total mass of the hydrogel microcapsule, and can be specifically demonstrated as 3.1-12%, 3.2-12%, 3.5-12%, 3.8-12%, 4-12%, 4.5-12%, 4.8-12%, 5-12%, 5.5-12%, 6-12%, 7-12%, 8-12%, 9-12%, 9.5-12%, 10-12%, 11-12%, 11.5-12%, 3-11.5%, 3-11.%, 3-10.5%, 3-10%, 3-9.5%, 3-9%, 3-8.5%, 3-8%, 3-7.5%, 3-7%, 3-6%, 3-6.8%, 3-6.5%, 3-6.2%, 3-6%, 3-5.5%, 3-5.2%, 3-5%, 3-4.8%, 3-4.5%, 3-4%, 3-3.5%, etc. This appropriate level of the mass dosage of the core material can maintain a good wrapping effect of the core material, avoid excessive diffusion of the oil-control component to the skin due to too much proportion of the core material compared to the wall material, or avoid difficulty in timely removal of the target removal substance adsorbed by the wall material due to too little proportion of the core material compared to the wall material.

[0052]

Core Material

[0053] As mentioned above, the core material is formed by the homogeneous dispersion of amphiphilic substances and oil-control components at a weight ratio of 2.2 - 8.7:1. The ratio of amphiphilic substances to oil-control components can be exemplified as 2.2 - 8.7:1, 2.1 - 8.7:1, 2.195 - 8.7:1, 2.19 - 8.7:1, 2.18 - 8.7:1, 2.17 - 8.7:1, 2.16 - 8.7:1, 2.15 - 8.7:1, 2.12 - 8.7:1, 2.10 - 8.7:1, 1.8 - 8.7:1, 1.6 - 8.7:1, 1.4 - 8.7:1, 1.2 - 8.7:1, 1.0 - 8.7:1, 0.8 - 8.7:1, 0.7 - 8.7:1, 0.6 - 8.7:1, 0.5 - 8.7:1, 0.4 - 8.7:1, 0.3 - 8.7:1, 0.2 - 8.7:1, 0.2 - 8.7:1, 0.15 - 8.7:1, 0.1 - 8.7:1, 0.08 - 8.7:1, 0.06 - 8.7:1, 0.04 - 8.7:1, 0.02 - 8.7:1, 0.01 - 8.7:1, 2.2 - 8.6:1, 2.2 - 8.5:1, 2.2 - 8.3:1, 2.2 - 8.1:1, 2.2 - 7.9:1, 2.2 - 7.7:1, 2.2 - 7.5:1, 2.2 - 7.3:1, 2.2 - 7.0:1, 2.2 - 6.8:1, 2.2 - 6.6:1, 2.2 - 6.3:1, 2.2 - 6.0:1, 2.2 - 5.6:1, 2.2 - 5.3:1, 2.2 - 5.0:1, 2.2 - 4.6:1, 2.2 - 4.4:1, 2.2 - 4.1:1, 2.2 - 3.7:1, 2.2 - 3.5:1, 2.2 - 3.2:1, 2.2 - 3.1:1, 2.2 - 2.8:1, 2.2 - 2.6:1, 2.2 - 2.5:1, 2.2 - 2.4:1, 2.2 - 2.35:1, etc.

[0054] In this technical solution, the above specific ratio of amphiphilic substances and oil-control components can ensure that the content of the oil-control components is in the minority, so as to ensure that the adsorption rate of the wall material to the target removal substances on the skin is significantly greater than the diffusion rate of the oil-control components to the skin during use, thereby reducing the driving force for the oil-control components to diffuse to the skin.

[0055] Here, the core material is formed by the homogeneous dispersion of amphiphilic substances and oil-control components. In actual operation, the amphiphilic substances and oil-control components are put into a conventional dispersion medium (such as a mixture of ethanol and water), and ultrasonic dispersion or mechanical dispersion can be assisted. When necessary, a pH regulator can be added until a single-phase dispersion state is formed.

[0056] In this text, the consideration for the core material to require amphiphilic substances and oil-control components to be dispersed into a homogeneous phase is that the amphiphilic substances and oil-control components have a maximized physical effect after dispersion. Of course, in an ideal situation, it even includes chemical bonds or van der Waals forces between active groups such as hydroxyl groups or carboxyl groups.

[0057] As a suitable but non-limiting specific example, the oil-control component can be at least one of salicylic acid, salicylic acid ester, tea tree essential oil, centella asiatica extract, hypericum perforatum extract, witch hazel extract, honey extract, and hyperin.

[0058] Without special limitation, the method for obtaining the hypericum perforatum extract can be demonstrated as follows: The preparation method of the hypericum perforatum extract includes the following steps: Take dry hypericum perforatum, crush it and sieve it through a 80-120 mesh sieve to obtain hypericum perforatum powder, add it to the enzymatic hydrolysis solution, and carry out enzymatic hydrolysis at 45-55 °C at a rotation speed of 50-100 rmp for 3-5 h. After inactivating in an ice bath for 10 min, centrifuge, filter to obtain filtrate A and residue A. Mix residue A with an ethanol solution, stir at 55-65 °C at a rotation speed of 20-40 rmp for 1-2 h, then centrifuge and filter to obtain filtrate B and residue B. Combine filtrate A and filtrate B and carry out extraction with supercritical carbon dioxide to obtain an extraction solution. Rotate and concentrate the extraction solution to 1 / 4 of the original volume to obtain the hypericum perforatum extract.

[0059] Here, the enzymatic hydrolysis solution is composed of 0.3-0.5 parts by weight of cellulase, 0.15-0.33 parts by weight of pectinase, 0.6-1.1 parts by weight of mannitol, 0.6-1.2 parts by weight of sodium dihydrogen phosphate, 0.24-0.5 parts by weight of polyvinylpyrrolidone, and 11-17.8 parts by weight of deionized water; the concentration of the mannitol is 0.4-0.8 mol / L; the parameters of the centrifugation step are all: 25 °C, the centrifugation rotation speed is 6000-12000 rmp, and the centrifugation time is 5-15 min; the filter cloth used in the filtration step is all 100-200 mesh; the parameters of the supercritical CO2 extraction are: the extraction pressure is 150-200 bar, and the extraction temperature is 40-60 °C; the eluent used in the supercritical CO2 extraction is a 70-80 wt% ethanol solution; the parameters of the rotation and concentration are: the vacuum degree is 0.06-0.1 MPa, and the rotation and concentration temperature is 60-70 °C.

[0060] Without special limitation, the centella asiatica extract and the witch hazel extract can refer to the method for obtaining the hypericum perforatum extract by the synergistic supercritical carbon dioxide extraction of enzymatic extraction and alcohol extraction, and can be adjusted conventionally according to the type of enzyme and the process conditions of supercritical carbon dioxide extraction on the basis of the hypericum perforatum extract.

[0061] Without special limitation, the preparation method of honey extract can be demonstrated to include the following steps: S1. Cut the honeycomb into appropriate sizes and place it into the feed inlet of a press; S2. Start the press, squeeze the honeycomb by the principle of rotation or lever, and honey flows out from the honey outlet. Repeat the operation until most of the honey is extracted, and then filter and purify it. The extracted honey is filtered through a stainless-steel filter screen (pore size ≤ 0.5 mm) to remove waxy particles; S3. Pasteurization (optional). If long-term preservation is required, the honey can be heated to 63 °C and maintained for 30 minutes, and then quickly cooled after killing microorganisms. Or the ultrasonic-assisted extraction method can be adopted, including: S1. Sample pretreatment, that is, crush the honeycomb fragments into uniform particles (particle size < 1 mm) and add an appropriate amount of distilled water to submerge them; S2. Ultrasonic extraction, that is, set the ultrasonic power (such as 40 kHz), time (30 - 60 minutes), and temperature (below 40 °C). The ultrasonic cavitation effect destroys the waxy structure and releases the honey components; S3. Centrifugal separation, that is, centrifuge the extract at 4000 - 5000 rpm for 10 minutes to remove solid residues; S4. Vacuum concentration, that is, concentrate it to the required concentration at a low temperature (≤ 40 °C) to retain heat-sensitive active substances (such as enzymes and vitamins). Sterilization and filling are carried out by irradiation sterilization or high-temperature short-time sterilization (HTST), and filling and sealing are carried out in a sterile environment.

[0062] As a suitable but non-limiting specific example, the HLB value of the amphiphilic substance is 7 - 30, and is further demonstrated as 7.1 - 30, 7.2 - 30, 7.5 - 30, 7.8 - 30, 8.2 - 30, 8.5 - 30, 9 - 30, 9.5 - 30, 10 - 30, 10.5 - 30, 11 - 30, 12 - 30, 13 - 30, 15 - 30, 18 - 30, 20 - 30, 21 - 30, 22 - 30, 23 - 30, 24 - 30, 25 - 30, 27 - 30, 28 - 30, 29 - 30, 29.5 - 30, 7 - 29.5, 7 - 29.0, 7 - 28, 7 - 27, 7 - 26, 7 - 25, 7 - 24, 7 - 23, 7 - 21, 7 - 20, 7 - 19, 7 - 18, 7 - 16, 7 - 14, 7 - 12, 7 - 10, 7 - 9, 7 - 8.5, 7 - 8, 7 - 7.5, etc. Thus, through this specific HLB value, the molecular compatibility between the amphiphilic substance and the oil-control component is ensured, so that the amphiphilic substance has a relatively satisfactory affinity for the oil-control component, and further enables the amphiphilic substance molecules to smoothly connect with the oil-control component molecules.

[0063] Based on the HLB level here, the amphiphilic substance is at least one of polysorbate, sodium lauroyl sarcosinate, cocamidopropyl betaine, glyceryl stearate, lecithin, and PEG-40 hydrogenated castor oil.

[0064] As a suitable but non-limiting specific example, the solvent of the core material is water and C1-4 alcohol. Thus, through these more appropriate solvent types, it can be ensured that the amphiphilic substance and the oil-control component have a better dispersion effect, and further achieve the physical interaction between molecules of the amphiphilic substance and the oil-control component.

[0065] Here, examples of C1-4 alcohol include methanol, ethanol, isopropyl alcohol, propylene glycol, etc.

[0066]

Wall material

[0067] As a suitable but non-limiting specific example, the wall material is at least one of agar, konjac gum, chitosan, locust bean gum, guar gum and its derivatives, methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 (a relatively mature commercial channel brand GT-730, which can be purchased from Hubei Xinyuhong Biomedical Technology or Wuhan Lanabai Pharmaceutical and Chemical Co., Ltd., etc.), and glycerol polyacrylate. Through these appropriate wall material types, it can be ensured that the quality of the capsule wall formation is relatively high, so as to improve the basic encapsulation effect of the capsule wall on the core material.

[0068]

Application

[0069] Regarding the application of the above oil-control composition, the oil-control composition is applied to cream, lotion, and aqueous products.

[0070] The auxiliary components such as cream, lotion, and aqueous products have been discussed above and will not be elaborated here.

[0071]

Implementation process of examples and comparative examples

[0072] Hereinafter, examples of the present application will be described. The examples described below are exemplary and are only used to explain the present application and should not be construed as a limitation to the present application. For those not specified in the examples regarding specific technologies or conditions, they shall be carried out according to the technologies or conditions described in the literature in the field or according to the product specifications. For the reagents or instruments not specified by the manufacturer, they are all conventional products that can be obtained through commercial purchase.

[0073] A. [Preparation process 1 of oil-control component]

[0074] S1. Put the amphiphilic substance and the oil-control component into a mixed solution of deionized water and ethanol with a volume ratio of 3:1, heat to 45-55 °C and stir evenly, homogenize at a homogenization pressure of 45 MPa for 8 min, and let the obtained dispersion stand for 30 min. If there is no layering observed, the core material solution is obtained.

[0075] S2. Prepare the wall material solution, that is, dissolve chitosan in acetic acid to form a chitosan solution.

[0076] S3. Prepare hydrogel microcapsules by the dropping method, specifically as follows: S31. Prepare an aqueous calcium chloride solution and fill it into the outer cylinder of the dropper; S32. Put silicone oil into the constant temperature water bath as the oil phase; S33. Let the well-stirred wall material solution flow out from the outer cylinder of the dropper, and the well-homogenized core material solution flow out from the inner cylinder of the dropper, and finally fall into the oil phase in the water bath to form a series of droplets, and separate the hydrogel microcapsules. The hydrogel microcapsule active component is obtained by hot air drying at 70 - 80 °C.

[0077] S4. Mix the active ingredient in S3 and the auxiliary materials according to the conventional addition amount to form an active composition.

[0078] Analyze the average particle size of the hydrogel microcapsules using a Mastersizer 3000 laser particle size analyzer.

[0079] Analyze the pore size rate of the hydrogel microcapsules using a fully automatic specific surface area analyzer Micromeritics TriStar II 2420.

[0080] B. [Preparation process 2 of the oil control component]

[0081] S1. Put the amphiphilic substance and the oil control component into a mixed solution of deionized water and ethanol with a volume ratio of 3:1, heat to 45 - 55 °C and stir evenly, homogenize at a homogenization pressure of 45 MPa for 8 min, and let the obtained dispersion stand for 30 min. If there is no layering, the core material solution is obtained.

[0082] S2. Prepare the wall material solution, that is, dissolve chitosan in acetic acid to form the same chitosan solution as in "A. [[Preparation process 1 of the oil control component]".

[0083] S3. Simply mix the wall material solution and the core material solution evenly by mechanical means without using the dropping method to form capsules, and obtain the active ingredient.

[0084] S4. Mix the active ingredient and the auxiliary materials according to the addition amount and form of the auxiliary materials in "A. [Preparation process 1 of the oil control component]" with the core material solution as the active ingredient.

[0085] C. [Preparation process 3 of the oil control component]

[0086] S1. Put the amphiphilic substance and the oil control component into a mixed solution of deionized water and ethanol with a volume ratio of 3:1, heat to 45 - 55 °C, without sufficient homogenization, let the obtained dispersion stand for 30 min, and if obvious layering appears, the core material solution is obtained.

[0087] S2. Prepare the wall material solution, that is, dissolve chitosan in acetic acid to form the same chitosan solution as in "A. [Preparation process of the hydrogel microcapsule]".

[0088] S3. Prepare hydrogel microcapsules using a dripping method under the same conditions as "A. [Preparation process of oil-controlling component 1]", specifically: S31. Prepare a calcium chloride aqueous solution and load it into the outer cylinder of the dripper; S32. Add silicone oil as the oil phase into a constant temperature water bath; S33. Allow the evenly stirred wall material solution to flow out from the outer cylinder of the dripper, and the homogenized core material solution to flow out from the inner cylinder of the dripper, and finally fall into the oil phase of the water bath to form a series of droplets, and separate the hydrogel microcapsules, and dry them with hot air at 70-80 degrees Celsius to obtain the active components of the hydrogel microcapsules.

[0089] S4. The active component and the auxiliary materials are mixed according to the auxiliary material addition amount and auxiliary material form as described in “A. [Preparation process 1 of oil control component]”.

[0090] According to the contents of “B. [Preparation process 2 of oil control component]” above and using the process conditions shown in Table 1, the oil control composition embodied in Comparative Example 1 was prepared.

[0091] According to the contents of “C. [Preparation process 3 of oil control component]” above and using the process conditions shown in Table 1, an oil control composition embodied by Comparative Example 2 was prepared.

[0092] According to the contents of “A. [Preparation process 1 of oil control component]” above and using the process conditions shown in Table 1, the oil control compositions embodied in the examples and comparative examples except Comparative Example 1 and Comparative Example 2 were prepared.

[0093] Table 1 Process conditions of various embodiments and comparative examples

[0094]

[0095]

[0096]

[0097]

[0098] Notes to Table 1: null indicates that the oil control composition does not have a hydrogel microcapsule structure and only contains a core material.

[0099]

evaluate

[0100] The following evaluations were performed on the oil control compositions of various examples and comparative examples prepared according to Table 1:

[0101] [Oil Control Evaluation]

[0102] 80 subjects aged 18-60 were selected and randomly divided into 16 groups, with 5 people in each group, wherein each group of volunteers corresponded to an example or a comparative example corresponding to the oil control composition.

[0103] After cleansing their faces in the morning and evening, an appropriate amount of essence was taken by each subject and evenly applied to the entire face. After 20 minutes, it was washed off with clean water, and this was continued for 28 days. Before using the product, 14 days after using the product, and 28 days after using the product, volunteers were arranged to conduct an oil control efficacy test to obtain the skin oil content. The oil control efficacy test was carried out 5 times on the forehead area using the German CK SM815 skin oil test probe Sebumeter SM 815, and the average value was taken.

[0104] The change rate after using the product for 28 days / 14 days = (oil content after 28 days / 14 days - oil content before use) divided by the oil content before use.

[0105] [Safety evaluation experiment]

[0106] 80 subjects, aged 18 - 60 years old, were randomly divided into 16 groups, with 5 people in each group. Among them, each group of volunteers corresponded to an oil control composition in an example or a comparative example.

[0107] After cleaning the back of the subject, the patch tester with the sample was applied to the selected position on the back with a non - irritating tape. After pasting, it was gently pressed with fingers to make it evenly adhere to the skin and lasted for 48 hours. The subject should keep the patch area dry within 48 hours, avoiding strenuous exercise, scratching the patch area, long - time sunlight exposure, etc. After 48 hours, the tester was removed and marked. After 40 minutes, when the indentation disappeared, the determination was carried out under sufficient light.

[0108] Table 2 Safety evaluation

[0109] Scoring Grade Reaction Symptoms Grade 0 Negative Reaction Grade 1 Suspicious Reaction, Only Slight Erythema Grade 2 Weak Positive Reaction, Erythema, Infiltration, Edema, May Have Papules Grade 3 Strong Positive Reaction, Erythema, Infiltration, Edema, Papules, Herpes, Reaction May Extend Beyond the Test Area Grade 4 Extremely Strong Positive Reaction, Obvious Erythema, Severe Infiltration, Edema, Confluent Herpes Reaction, Extends Beyond the Test Area

[0110] Table 3 Oil control results

[0111]

[0112] Table 4 Safety test

[0113] Grade 0 Grade 1 Grade 2 Grade 3 Grade 4 Example 1 5 people 0 people 0 people 0 people 0 people Example 2 5 people 0 people 0 people 0 people 0 people Example 3 5 people 0 people 0 people 0 people 0 people Example 4 5 people 0 people 0 people 0 people 0 people Example 5 5 people 0 people 0 people 0 people 0 people Example 6 5 people 0 people 0 people 0 people 0 people Example 7 5 people 0 people 0 people 0 people 0 people Example 8 5 people 0 people 0 people 0 people 0 people Example 9 5 people 0 people 0 people 0 people 0 people Example 10 5 people 0 people 0 people 0 people 0 people Example 11 5 people 0 people 0 people 0 people 0 people Example 12 5 people 0 people 0 people 0 people 0 people Comparative Example 1 5 people 0 people 0 people 0 people 0 people Comparative Example 2 5 people 0 people 0 people 0 people 0 people Comparative Example 3 5 people 0 people 0 people 0 people 0 people Comparative Example 4 4 people 1 person 0 people 0 people 0 people

[0114] As can be seen from Table 3 and Table 4, the oil control effect of Example 1 is significantly higher than that of Comparative Example 1, which shows the technical contribution of the hydrogel microcapsule structure to the oil control result compared with the simple physical mixture of the core material and the wall material;

[0115] The oil control effect of Example 1 is significantly higher than that of Comparative Example 2, which shows the technical contribution of the full dispersion of amphiphilic substances and oil - control components in the core material to the oil control result compared with the non - dispersed state;

[0116] The oil control effect of Example 1 is significantly higher than that of Comparative Example 3 and Comparative Example 4, which shows the technical contribution of the specific ratio of amphiphilic substances and oil - control components in the core material to the oil control result;

[0117] The oil control effect of Example 6 is significantly higher than that of Example 7 and Example 8, which shows the technical contribution of a specific range of the average particle size of the hydrogel microcapsules to the oil control result;

[0118] The oil control effect of Example 6 is significantly higher than that of Example 9 and Example 10, which shows the technical contribution of a specific range of the porosity of the hydrogel microcapsules to the oil control result;

[0119] The oil control effect of Example 6 is significantly higher than that of Example 11 and Example 12, which shows the technical contribution of a specific range of the mass ratio of the core material to the oil control result.

[0120] The above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit it; although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present application, and they should all be covered within the scope of the claims and the description of the present application. In particular, as long as there is no structural conflict, the technical features mentioned in each embodiment can be combined in any way. The present application is not limited to the specific embodiments disclosed in the text, but includes all technical solutions falling within the scope of the claims.

Claims

1. An oil-control composition, characterized in that, It contains excipients and hydrogel microcapsules as the active ingredient; Among them, the hydrogel microcapsules have a hydrogel wall material and a core material; the core material is formed by dispersing amphiphilic substances and oil-control components in a homogeneous phase at a weight ratio of 2.2-8.7:

1.

2. The oil-control composition according to claim 1, wherein The oil-control component is at least one of salicylic acid, salicylic acid ester, tea tree essential oil, centella asiatica extract, hypericum perforatum extract, witch hazel extract, honey extract, hyperin.

3. The oil-control composition according to claim 1, wherein The HLB value of the amphiphilic substance is 7-30.

4. The oil-control composition according to claim 3, characterized in that, The amphiphilic substance is at least one of polysorbate, sodium lauroyl sarcosinate, cocamidopropyl betaine, glyceryl stearate, lecithin, PEG-40 hydrogenated castor oil.

5. The oil-control composition according to claim 1, wherein The average particle size of the hydrogel microcapsules is 30-300 microns.

6. The oil-control composition according to claim 3, wherein The porosity of the hydrogel microcapsules is 50-80%.

7. The oil-control composition according to claim 1, wherein The solvent of the core material is water or C1-4 alcohol.

8. The oil-control composition according to claim 1, wherein The wall material is at least one of agar, konjac gum, chitosan, locust bean gum, guar gum and its derivatives, methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, PEG-240 / HDI copolymer bis-decyldodecyl polyethylene glycol-20, glycerol polyacrylate.

9. The oil-control composition according to claim 1, wherein The mass dosage of the core material of the hydrogel microcapsules is 3-12% based on the total mass of the hydrogel microcapsules.

10. Use of an oil-control composition according to any one of claims 1 to 9, characterized in that, The oil-control composition is applied to cream, lotion, and aqueous products.

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