Smearing type mask and preparation method thereof

Abstract

The invention discloses a smearing type mask and a preparation method thereof, and belongs to the technical field of cosmetics. The smearing type mask is prepared from coenzyme Q10 lipidosome, tetrahydrocurcumin lipidosome, lotus flower extract, citrus peel extract, a humectant, grease, an emulsifier, an excipient, a skin conditioner, a pH regulator and water. The invention further provides a preparation method of the smearing type mask. The preparation method comprises the following steps: heating the component A to 80-85 DEG C, and preserving heat; heating the component B to 80-85 DEG C, keeping the temperature, and then mixing, homogenizing and emulsifying the component A and the component B; then stirring and cooling to 65-75 DEG C, then adding the component C and the component D in sequence, and stirring and homogenizing; cooling to 40-45 DEG C, and continuously adding the component E, the component F and the component G; and continuing to add the component H, then adding the component I, stirring and homogenizing to obtain the smearing type mask. The mask provided by the invention has the use effects of moisturizing, tightening, resisting wrinkles and brightening.

Description

[0001] This application is a divisional application. The application number of the original application is: 2024102923611, the application date is: March 14, 2024, and the patent title is: A smearable mask and its preparation method. Technical Field

[0002] The present invention relates to the technical field of cosmetics, and specifically relates to a smearable mask and its preparation method. Background Art

[0003] The smearable mask is a unique dosage form of cosmetics. In the early stage, there were more mud masks, which were mainly used as cleansing products to clean the skin by adsorbing oil and dirt on the skin. With the upgrading of consumer demand, more and more smearable mask products have emerged, including gel types, cream types, double - dosage form film - forming types, and single - dosage form film - forming types. Functionally, they are mainly manifested in moisturizing, whitening, and cleansing, with relatively single efficacy and difficult to simultaneously meet multi - dimensional effects such as moisturizing, firming, anti - wrinkle, and brightening.

[0004] For example, the moisturizing and whitening smearable mask proposed in the prior art CN109364012A includes fermented milk, aloe vera juice, cucumber juice, lemon essential oil, and sage essential oil. The main function of this mask is whitening and it is difficult to take into account other effects.

[0005] Another example is the emulsified smearable mask with soothing and repairing effects proposed in the prior art CN114948769A. This mask uses mild and skin - friendly hydrogenated hemolytic lecithin as the main emulsifier, and at the same time uses sodium hyaluronate and phytocompound as a soothing and repairing combination, combined with emollients, vegetable oils, and mixed alcohols, etc., which can gently soothe various discomfort symptoms of the skin, repair the sebum membrane and skin barrier. The problem it solves is skin repair, and the effect is also relatively single.

[0006] Therefore, it is necessary to study new smearable masks to simultaneously meet at least two - dimensional effects among moisturizing, firming, anti - wrinkle, and brightening. Summary of the Invention

[0007] The purpose of the present invention is to overcome the above - mentioned technical deficiencies, provide a smearable mask and its preparation method, and solve the technical problem that the smearable mask in the prior art is difficult to simultaneously meet the effects of moisturizing, firming, anti - wrinkle, and brightening.

[0008] To achieve the above - mentioned technical purpose, the technical solution of the present invention provides a smearable mask, which includes coenzyme Q10 liposome, tetrahydrocurcumin liposome, lotus extract, citrus peel extract, moisturizer, oil, emulsifier, excipient, skin conditioner, pH regulator, and water.

[0009] In some embodiments, it further includes a preservative; and / or, it further includes a colorant; and / or, it further includes a fragrance.

[0010] In some embodiments, calculated based on a total of 100% by mass percentage, it includes 1%-5% of coenzyme Q10 liposome, 0.1%-2% of tetrahydrocurcumin liposome, 0.1%-1% of lotus extract, 0.1%-1% of citrus peel extract, 5%-17% of a humectant, 1%-10% of an oil, 1%-5% of an emulsifier, 0.1-15% of an excipient, 0.0001%-10% of a skin conditioner, 0.01%-0.1% of a pH regulator, and the balance is water.

[0011] In some embodiments, calculated based on a total of 100% by mass percentage, it further includes 0.001%-3.5% of a preservative; and / or, it further includes 0.01%-1.5% of a colorant; and / or, it further includes 0.1%-0.5% of a fragrance.

[0012] In some embodiments, the humectant includes 10-12% of glycerol and 0.5%-1% of panthenol; and / or, the oil includes 3-4% of caprylic / capric triglyceride, 2-3% of cetyl ethylhexanoate, 0.5-1% of shea butter, 0.2-0.5% of wheat germ oil, and 0.2-0.5% of oat kernel oil; and / or, the emulsifier includes 0.2%-0.5% of cetearyl glucoside, 0.5%-0.6% of glyceryl stearates, and 0.5%-0.6% of PEG-100 stearate; and / or, the excipient includes 0.5%-1% of titanium dioxide, 0.2%-0.25% of sodium polyacrylate grafted starch, 3%-3.2% of cetearyl alcohol, 2%-3% of bentonite, 0.2%-0.25% of hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, 0.1-0.3% of carbomer, and 0.3-0.4% of sodium polyacrylate; and / or, the skin conditioner includes 0.2%-0.3% of allantoin, 0.02-0.03% of hydroxyphenyl propanamide benzoic acid, 1-1.5% of purslane extract, 0.05%-0.1% of pentaerythrityl tetra(bis-tert-butyl hydroxyhydrocinnamate), 0.001%-0.02% of glabridin, 0.001%-0.02% of resveratrol, 0.001%-0.02% of dimethylmethoxy chroman-6-ol, 0.005%-0.1% of diglucosyl gallic acid, 0.02%-0.05% of grape seed extract, 0.0001%-0.0002% of epigallocatechin gallate, and 0.2%-0.3% of inositol; and / or, the pH regulator is 0.03%-0.04% of sodium hydroxide.

[0013] In some embodiments, the preservative includes 1% - 1.2% of 1,2 - hexanediol, 0.4% - 0.5% of p - hydroxyacetophenone, 0.002% - 0.003% of glyceryl caprylate, and 0.03% - 0.04% of octanoyl hydroxamic acid; the colorant includes 0.07% - 0.08% of Phellodendron amurense extract, 0.11% - 0.12% of caramel color, 0.02% - 0.05% of rose flower extract, and 0.025 - 0.05% of Gardenia jasminoides Ellis fruit extract; and / or, the fragrance includes 0.3% - 0.42% of sweet orange oil.

[0014] In addition, the present invention also provides a preparation method of the above - mentioned smear - type facial mask, which includes the following steps:

[0015] S1. Heat component A to 80 - 85 °C and keep it warm, then stir, homogenize, dissolve and disperse; heat component B to 80 - 85 °C and keep it warm, stir, homogenize, dissolve and disperse, and then mix and homogenize and emulsify component A and component B;

[0016] S2. Then stir and cool down to 65 - 75 °C, and then successively add component C and component D and stir and homogenize;

[0017] S3. Cool down to 40 - 45 °C, and continue to add component E, component F and component G;

[0018] S4. Continue to add component H, and then add component I and stir and homogenize to obtain the smear - type facial mask;

[0019] Component A is obtained by mixing water, glycerol, titanium dioxide, panthenol, sodium polyacrylate grafted starch, carbomer and allantoin;

[0020] Component B is obtained by mixing triglyceride of caprylic / capric acid, cetearyl alcohol, cetyl ethylhexanoate, cetearyl glucoside, shea butter, PEG - 100 stearate, glycerol stearates, oat kernel oil, wheat germ oil, pentaerythrityl tetra - (bis - tert - butylhydroxyhydrocinnamate), dimethylmethoxy chromanol, resveratrol;

[0021] Component C is obtained by mixing sodium hydroxide and water; component D is obtained by mixing bentonite and water;

[0022] Component E is obtained by mixing inositol and water; component F is obtained by mixing glabridin and glycerol;

[0023] Component G is obtained by mixing coenzyme Q10 liposome, diglucosyl gallic acid, tetrahydrocurcumin liposome, grape seed extract and epigallocatechin gallate glucoside; component H is obtained by mixing lotus flower extract, citrus peel extract, purslane extract and hydroxyphenyl propanamide benzoic acid; component I is acryloyldimethyltaurate / VP copolymer.

[0024] In some embodiments, the component A further includes p - hydroxyacetophenone; and / or, the component G further includes 1,2 - hexanediol, glyceryl caprylate and octanoyl hydroxamic acid; and / or, the component G further includes sweet orange oil.

[0025] In some embodiments, in step S4, after adding the I - phase and stirring for homogenization, it further includes continuously adding the component J, component K, component L and stirring, and then adding the component M and stirring to obtain the smearable facial mask.

[0026] The component J is obtained by mixing phellodendron amurense extract and water; the component K is obtained by mixing caramel color and water; the component L is obtained by mixing rose extract and gardenia fruit extract; the component M is obtained by mixing sodium polyacrylate, glycerol and water.

[0027] In some embodiments, in step S2, before adding the component D, it further includes subjecting the component D to a heat preservation treatment at 80 - 85 °C.

[0028] Compared with the prior art, the beneficial effects of the present invention include: the smearable facial mask proposed by the present invention can achieve the use effects of multiple functions such as moisturizing, firming, anti - wrinkle and brightening. The main reason for generating such beneficial effects is through the cooperation of various raw materials, promoting the penetration of the active ingredients, improving the absorption and utilization of the active substances, and further achieving the use effects of multiple functions of moisturizing, firming, anti - wrinkle and brightening. Detailed Embodiments

[0029] The present detailed embodiment provides a smearable facial mask, which includes coenzyme Q10 liposome, tetrahydrocurcumin liposome, lotus extract, citrus peel extract, humectant, oil, emulsifier, excipient, skin conditioner, pH regulator and water.

[0030] In some embodiments, it further includes a preservative; and / or, it further includes a colorant; and / or, it further includes a fragrance.

[0031] In some embodiments, calculated according to 100% by mass percentage in total, the smearable facial mask includes 1% - 5% of coenzyme Q10 liposome, 0.1% - 2% of tetrahydrocurcumin liposome, 0.1% - 1% of lotus extract, 0.1% - 1% of citrus peel extract, 5% - 17% of humectant, 1% - 10% of oil, 1% - 5% of emulsifier, 0.1 - 15% of excipient, 0.0001% - 10% of skin conditioner, 0.01% - 0.1% of pH regulator, and the balance is water.

[0032] In some embodiments, calculated according to 100% by mass percentage in total, it further includes 0.001% - 3.5% of preservative; and / or, it further includes 0.01% - 1.5% of colorant; and / or, it further includes 0.1% - 0.5% of fragrance.

[0033] In some embodiments, the humectant includes 10-12% glycerol and 0.5%-1% panthenol; and / or, the oil includes 3-4% triglyceride caprylate / caprate, 2-3% cetyl ethylhexanoate, 0.5-1% shea butter, 0.2-0.5% wheat germ oil, and 0.2-0.5% oat kernel oil; and / or, the emulsifier includes 0.2%-0.5% cetearyl glucoside, 0.5%-0.6% glyceryl stearates, and 0.5%-0.6% PEG-100 stearate; and / or, the excipient includes 0.5%-1% titanium dioxide, 0.2%-0.25% sodium polyacrylate grafted starch, 3%-3.2% cetearyl alcohol, 2%-3% bentonite, 0.2%-0.25% hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.1-0.3% carbomer, and 0.3-0.4% sodium polyacrylate; and / or, the skin conditioner includes 0.2%-0.3% allantoin, 0.02-0.03% hydroxyphenyl propionamide benzoic acid, 1-1.5% purslane extract, 0.05%-0.1% pentaerythrityl tetra(bis-tert-butyl hydroxyhydrocinnamate), 0.001%-0.02% glabridin, 0.001%-0.02% resveratrol, 0.001%-0.02% dimethylmethoxy chromanol, 0.005%-0.1% diglucosyl gallic acid, 0.02%-0.05% grape seed extract, 0.0001%-0.0002% epigallocatechin gallate glucoside, and 0.2%-0.3% inositol; and / or, the pH regulator is 0.03%-0.04% sodium hydroxide.

[0034] In some embodiments, the preservative includes 1%-1.2% 1,2-hexanediol, 0.4%-0.5% p-hydroxyacetophenone, 0.002%-0.003% glyceryl caprylate, and 0.03%-0.04% octanoyl hydroxamic acid; the colorant includes 0.07%-0.08% phellodendron extract, 0.11%-0.12% caramel color, 0.02%-0.05% rose extract, and 0.025-0.05% gardenia fruit extract; and / or, the fragrance includes 0.3%-0.42% sweet orange oil.

[0035] This specific embodiment also provides a preparation method of the above-mentioned smear-type mask, including the following steps:

[0036] S1. Heat component A to 80-85°C and keep it warm, then stir, homogenize, dissolve and disperse; heat component B to 80-85°C and keep it warm, stir, homogenize, dissolve and disperse, and then mix and homogenize and emulsify component A and component B.

[0037] S2. Then, stir and cool down the temperature to 65 - 75°C. After that, keep the D component at 80 - 85°C for heat preservation treatment, and then add the C component and the D component successively and stir for homogenization.

[0038] S3. Cool down the temperature to 40 - 45°C, and continue to add the E component, the F component and the G component.

[0039] S4. Continue to add the H component, and then add the I component and stir for homogenization to obtain the smearable facial mask.

[0040] The A component is obtained by mixing water, glycerol, titanium dioxide, panthenol, sodium polyacrylate grafted starch, carbomer and allantoin.

[0041] The B component is obtained by mixing triglyceride caprylate / caprate, cetearyl alcohol, cetyl ethylhexanoate, cetearyl glucoside, shea butter, PEG - 100 stearate, glycerol stearates, oat kernel oil, wheat germ oil, pentaerythrityl tetra(bis - tert - butylhydroxyhydrocinnamate), dimethylmethoxy chromanol and resveratrol.

[0042] The C component is obtained by mixing sodium hydroxide and water; the D component is obtained by mixing bentonite and water.

[0043] The E component is obtained by mixing inositol and water; the F component is obtained by mixing glabridin and glycerol.

[0044] The G component is obtained by mixing coenzyme Q10 liposome, diglucosyl gallic acid, tetrahydrocurcumin liposome, grape seed extract and epigallocatechin gallate glucoside; the H component is obtained by mixing lotus extract, citrus peel extract, purslane extract and hydroxyphenyl propanamide benzoic acid; the I component is acryloyldimethyltaurate / VP copolymer.

[0045] In some embodiments, the A component in the above preparation method further includes p - hydroxyacetophenone; and / or, the G component further includes 1,2 - hexanediol, glycerol caprylate and octanoyl hydroxamic acid; and / or, the G component further includes sweet orange oil.

[0046] In some embodiments, in step S4, after adding the I component and stirring for homogenization, it further includes continuing to add the J component, the K component and the L component and stirring, and then adding the M component and stirring to obtain the smearable facial mask; the J component is obtained by mixing phellodendron amurense extract and water; the K component is obtained by mixing caramel color and water; the L component is obtained by mixing rose extract and gardenia fruit extract; the M component is obtained by mixing sodium polyacrylate, glycerol and water.

[0047] In order to make the objectives, technical solutions and advantages of the present invention more clear and understandable, the present invention will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0048] In the present invention, references are made to "some embodiments", "this embodiment" and examples, etc., which describe subsets of all possible embodiments. However, it can be understood that "some embodiments" can be the same subset or different subsets of all possible embodiments, and can be combined with each other without conflict.

[0049] If similar descriptions such as "first / second" appear in the application documents, the following explanation is added. In the following description, the terms "first\second\third" only distinguish similar objects and do not represent a specific order for the objects. It can be understood that "first\second\third" can be interchanged with a specific order or sequence when permitted, so that the embodiments described here can be implemented in an order other than that described here.

[0050] In this embodiment, the term "and / or" only describes the association relationship of associated objects and indicates that there can be three relationships. For example, object A and / or object B can represent three situations: object A exists alone, object A and object B exist simultaneously, and object B exists alone.

[0051] Embodiment 1

[0052] This embodiment provides a preparation method for a smear mask, which includes the following steps:

[0053] Add component A to the emulsifying pot (main pot), heat to 80 - 85 °C, keep warm for 20 minutes, and stir, homogenize, dissolve and disperse evenly;

[0054] Add component B to the oil pot, heat to 80 - 85 °C, keep warm for 20 minutes, and stir, homogenize, dissolve and disperse evenly to ensure that there are no particles in the oil phase;

[0055] Turn on the homogenizer, pump the raw material of component B into the emulsifying pot containing component A, homogenize and emulsify completely, and keep warm for 5 - 10 min;

[0056] Separate new containers are used to pre-dissolve or disperse component C, component D, component E, component F, component H, component J, and component K respectively for later use; component D is kept warm in a water bath at 85 °C for 30 minutes; it should be noted that for component C, water is added first and then sodium hydroxide is slowly added, and after complete dissolution, it is cooled for later use; in addition, for other components, all the liquids are first poured into the container, and the stirring paddle is turned on and the powder is slowly added to avoid caking;

[0057] After the mixed components of A and B are homogenized well, stir and cool down the temperature to about 70°C, add component C and homogenize for 2 minutes, then add component D and homogenize for 3 minutes;

[0058] When the temperature drops to 45°C, add component E, component F, and component G into the emulsifying pot respectively and stir evenly;

[0059] Slowly add component H while stirring, adding in small amounts and multiple times, then add component I and homogenize for 3 minutes until the material is completely mixed and uniform;

[0060] Add component J, component K, and component L respectively, stir evenly, and after passing the inspection, add component M and stir evenly;

[0061] Stir evenly, take a sample for inspection, and discharge the material after passing the inspection.

[0062] Component A is obtained by mixing deionized water, glycerin, titanium dioxide, panthenol, p-hydroxyacetophenone, sodium polyacrylate grafted starch, carbomer, and allantoin;

[0063] Component B is obtained by mixing triglyceride caprylate / caprate, cetearyl alcohol, cetyl ethylhexanoate, cetearyl glucoside, shea butter, PEG-100 stearate, glycerol stearates, oat (AVENA SATIVA) kernel oil, wheat germ oil, pentaerythrityl tetra(bis-tert-butylhydroxyhydrocinnamate), dimethylmethoxy chromanol, and resveratrol;

[0064] Component C is obtained by mixing sodium hydroxide and an appropriate amount of deionized water; Component D is obtained by mixing bentonite and an appropriate amount of deionized water; Component E is obtained by mixing inositol and an appropriate amount of deionized water; Component F is obtained by mixing glabridin and an appropriate amount of glycerin; Component G is obtained by mixing coenzyme Q10 liposome, 1,2-hexanediol, octanoyl hydroxamic acid, glyceryl caprylate, diglucosyl gallic acid, tetrahydrocurcumin liposome, grape seed extract, sweet orange oil, and epigallocatechin gallate glucoside components; Component H is obtained by mixing lotus (NELUMBO NUCIFERA) flower extract, citrus (CITRUS RETICULATA) peel extract, purslane extract, and hydroxyphenylpropanamide benzoic acid; Component I is acryloyldimethyltaurate / VP copolymer; Component J is obtained by mixing phellodendron bark extract and an appropriate amount of deionized water, Component K is obtained by mixing caramel color and an appropriate amount of deionized water; Component L is obtained by mixing hybrid rose (ROSA HYBRID) flower extract and gardenia (GARDENIA FLORIDA) fruit extract; Component M is obtained by mixing sodium polyacrylate, glycerin, and deionized water.

[0065] Five groups of smear masks were prepared according to the method proposed in this example and the dosage of each raw material in Table 1, namely the first group, the second group, the third group, the fourth group, and the fifth group.

[0066] Table 1 Mass percentage dosage of each raw material in Example 1

[0067]

[0068]

[0069] Comparative Example 1

[0070] The smear-type facial mask of this comparative example was prepared according to the preparation method of Example 1, except that the dosages of each raw material were different, including Comparative Group 1, Comparative Group 2, Comparative Group 3, Comparative Group 4, Comparative Group 5 and Comparative Group 6. See Table 2 for details.

[0071] Table 2 Dosage of each raw material in the smear-type facial mask in Comparative Example 1

[0072]

[0073]

[0074] I. Efficacy test

[0075] 1. Test basis:

[0076] [1] T / GDCDCC-020-2022 Test method for firming efficacy of cosmetics

[0077] [2] T / ZHCA006-2019 Test method for anti-wrinkle efficacy of cosmetics

[0078] [3] T / GDCDCC-019-2022 Test method for anti-wrinkle efficacy of cosmetics

[0079] [4] Laboratory method of CTI Testing and Certification Group Co., Ltd.

[0080] 2. Test purpose:

[0081] This test measures the skin elasticity R2 value, skin elasticity F3 / F4 value, skin firming parameter F4 value, and skin glossiness of 32 healthy female subjects before and after using the test sample, analyzes the skin glossiness, skin wrinkle length, skin wrinkle volume, skin wrinkle number, and skin wrinkle area, and conducts self-evaluation by the subjects to verify the efficacy of the submitted sample in firming, anti-wrinkle, nourishing, and improving glossiness.

[0082] 3. Sample usage method:

[0083] After washing the face with clean water, take an appropriate amount of the facial mask material, evenly apply it to the whole face from the inside out, pay attention to avoiding the eyes, let it stand for about 15 - 20 minutes, and then use a cotton pad, a facial sponge or a face towel to wash off the residual facial mask material with clean water.

[0084] 4. Subject Information:

[0085] The subjects were female, aged 35 - 53 years old. The number of recruited subjects was 40, the number of subjects screened and enrolled was 35, the number of subjects who failed to complete the test was 3, and the number of subjects with valid data for analysis was 32. There were 5 groups of examples and 6 groups of comparative examples. All 32 individuals would try the samples of these 11 groups (5 groups of examples + 6 groups of comparative examples) one by one.

[0086] 5. Test items are shown in Table 3:

[0087] Table 3

[0088]

[0089] 6. Test Results

[0090] 1) Skin elasticity assessment, as shown in Table 4:

[0091] Table 4

[0092] Skin elasticity R2 value (14 days) Skin elasticity R3 / R4 value (14 days) The first group Increased by 9.2% Increased by 11.5% The second group Increased by 11.3% Increased by 13.8% The third group Increased by 12.1% Increased by 14.2% The fourth group Increased by 13.5% Increased by 15.9% The fifth group Increased by 15.6% Increased by 18.3% Control group 1 Increased by 1.7% Increased by 2% Control group 2 Increased by 2.3% Increased by 2.9% Control group 3 Increased by 2.7% Increased by 3.1% Control group 4 Increased by 2.5% Increased by 2.8% Control group 5 Increased by 2.2% Increased by 2.5% Control group 6 Increased by 2.6% Increased by 3.7%

[0093] 2) Skin firmness assessment, as shown in Table 5:

[0094] Table 5

[0095]

[0096]

[0097] 3) Skin glossiness assessment, as shown in Table 6:

[0098] Table 6

[0099]

[0100] 4) Skin wrinkle assessment, as shown in Table 7:

[0101] Table 7

[0102]

[0103]

[0104] From the test results in Tables 4 - 7, it can be seen that the smear-type mask of Example 1 has significantly better effects in improving skin elasticity, skin firmness, skin glossiness, and skin wrinkles than the mask of Comparative Example 1. This also shows that the effect of the mask of the present invention is the result of the synergistic action of each component.

[0105] In addition, those skilled in the art can understand that although no examples lacking one or more of preservatives, colorants, and fragrances are given, the lack of one or more of these raw materials does not affect the efficacy of the facial mask, and the examples lacking one or more of these raw materials also fall within the scope of the examples of this application.

[0106] II. Safety Test

[0107] (I) Chicken Embryo Chorioallantoic Membrane Vascular Assay (CAMVA)

[0108] Test sample: The smear-type facial mask sample prepared in the first group of Example 1, dissolved in ultrapure water and diluted according to the actual experimental situation.

[0109] Positive control: Weigh 0.1442 g of SDS, make up the volume to 10 mL with ultrapure water and mix well to prepare 0.05 mol / L SDS.

[0110] Negative control: Ultrapure water

[0111] Experimental materials

[0112] Chicken embryos: SPF-grade White Leghorn chickens, purchased from Jiangsu Boehringer Ingelheim Vetmedica Co., Ltd.

[0113] Production license number: SCXK (Su) 2022-0002

[0114] Cultivation conditions: Incubator temperature 37.5 ± 0.5 °C, relative humidity 55 - 70%

[0115] Solvent: Olive oil or ultrapure water

[0116] Other materials: Teflon ring

[0117] Test procedures:

[0118] Preparation of CAM:

[0119] Day 0: Purchase fertilized chicken embryos and transport them to the laboratory. Check the quality of the chicken embryos by candling, and discard unfertilized, inactive, or defective chicken embryos. Clean the surface with 70% - 75% alcohol and place them in the incubator at 37.5 ± 0.5 °C for incubation.

[0120] Day 3: Place the chicken embryos horizontally and continue incubation.

[0121] Day 4: Take out the chicken embryos from the incubator and check the position of the embryos by candling. Make a small hole at the small end of the chicken embryo, carefully draw out about 2.5 - 3.0 mL of egg white with a syringe, and seal the small hole with collodion. Make a rectangular window above the embryo, and then seal the notch with a transparent film. Continue incubation and check every day, and discard any abnormal chicken embryos.

[0122] Day 14: Remove the chicken embryo from the incubator, remove the membrane, and place a Teflon ring as the action area for the sample.

[0123] Screening experiment

[0124] Use 3 chicken embryos for each concentration. Take 40 μL of the first group of samples of the tested Example 1 and add it into the ring. Place the chicken embryos in the incubator environment for 30 ± 5 min. After incubation, take out the chicken embryos from the incubator, observe and compare the changes in the CAM blood vessels inside and outside the ring, and evaluate the blood vessel damage inside the ring.

[0125] Formal experiment

[0126] Use 10 chicken embryos for each concentration. The operation process is the same as that of the screening experiment, and the relevant evaluation criteria are shown in Table 8.

[0127] Table 8

[0128]

[0129] If any blood vessel changes are observed, the blood vessel reaction can be determined as positive. Record all positive or negative effects, and calculate the RC50 using probability analysis, that is, the concentration of the test substance that causes 50% of the chicken embryos to show a positive reaction. The determination is shown in Table 9:

[0130] Table 9

[0131] RC50 Prediction classification >3.0％ Non-irritating ≥1.0％，≤3.0％ Unable to predict <1.0％ Irritating

[0132] Data analysis

[0133] The control group and the results are shown in Table 10 below:

[0134] Table 10

[0135]

[0136] The results of the screening experiment are shown in Table 11 below:

[0137] Table 11

[0138]

[0139] The results of the formal experiment are shown in Table 12 below:

[0140] Table 12

[0141]

[0142] Calculation result: Calculate the RC50: > 100%

[0143] Conclusion: According to the judgment criteria of the CAMVA experiment, under the conditions of this experiment, the RC50 of the sample is > 100%, which means it is non-irritating. That is, under the conditions of this experiment, this product is mild and non-irritating. The same test results were obtained for the smear masks prepared in the second to fifth groups of Example 1.

[0144] (II) Human Skin Patch Test

[0145] 1. Test substance: The smear mask prepared in the first group of Example 1.

[0146] 2. Negative control: Blank control.

[0147] 3. Subjects: A total of 30 people, 2 males and 28 females, aged 19 to 44 years old, with an average age of 30.60 ± 7.82 years old, 100% sensitive skin, meeting the volunteer selection criteria for subjects.

[0148] 4. Patch test method: Select qualified patch test equipment. Using the closed patch test method, place approximately 0.020 g - 0.025 g of the test substance in the patch tester, and apply it to the flexor side of the subject's forearm with a low-allergenic tape. After 24 hours, remove the test substance, and observe the skin reaction at 0.5, 24, and 48 hours after removal respectively. Record the results according to the skin reaction grading standard in the currently effective technical specifications.

[0149] The skin reaction grading standard is shown in Table 13:

[0150] Table 13

[0151]

[0152] The test results are shown in Table 14.

[0153] Table 14

[0154]

[0155] The results of the human skin patch test showed that 0 out of 30 people had skin adverse reactions. The entire test was clinically evaluated by a dermatologist.

[0156] III. Self-evaluation by Subjects

[0157] Test substance: The smear mask prepared in the first group of Example 1.

[0158] Number of subjects: 32 people

[0159] Usage method:

[0160] Questions 1 - 10: (Scored on a 5-point scale) 1 point represents strong disagreement, 2 points represents disagreement, 3 points represents neither agreement nor disagreement, 4 points represents agreement, and 5 points represents strong agreement.

[0161] Those with a statistical score of ≥4 points are the valid number of people. The calculation method of the recognition degree is as follows:

[0162] Recognition degree = [(Number of people with a score of 4 points (recognized) + Number of people with a score of 5 points (highly recognized)) / Total number of people] × 100%

[0163] Question 11: Count the proportion of the number of people who "recognize" and "do not recognize".

[0164] The recognition degree of the self-evaluation results of the subjects is shown in Table 15. It should be noted that the P value in Table 15 is the probability of no efficacy in statistics. The smaller the value, the higher the significance of the effect.

[0165] Table 15

[0166]

[0167] Conclusion:

[0168] The subjects recognized that the test sample has moisturizing, firming, anti-wrinkle effects, and improves the glossiness. The smear-type mask samples prepared in the second to fifth groups of Example 1 also had test results equivalent to those of the mask in the first group of Example 1.

[0169] The specific implementation manners of the present invention described above do not constitute a limitation on the protection scope of the present invention. Any other corresponding changes and deformations made according to the technical concept of the present invention shall be included in the protection scope of the claims of the present invention.

Claims

1. A smear-type facial mask, characterized in that, Calculated as a total of 100% by mass percentage, it includes: Coenzyme Q10 liposome 1% - 5%, Tetrahydrocurcumin liposome 0.1% - 2%, Lotus extract 0.1% - 1%, Citrus peel extract 0.1% - 1%, Humectant 5% - 17%, Oil 1% - 10%, Emulsifier 1% - 5%, Excipient 0.1 - 15%, Skin conditioner 0.0001% - 10%, pH regulator 0.01% - 0.1%, The balance is water; The humectant includes 10 - 12% glycerin and 0.5% - 1% panthenol; The oil includes 3 - 4% triglyceride caprylic / capric acid, cetyl ethylhexanoate 2 - 3%, shea butter 0.5 - 1%, wheat germ oil 0.2 - 0.5% and oat kernel oil 0.2-0.5％； The emulsifier includes 0.2% - 0.5% cetearyl glucoside, glycerol stearates 0.5% - 0.6% and PEG - 100 stearate 0.5% - 0.6%; The excipient includes 0.5% - 1% titanium dioxide, sodium polyacrylate grafted starch 0.2% - 0.25%, cetearyl alcohol 3% - 3.2%, bentonite 2% - 3%, acryloyldimethyltaurate / hydroxyethyl acrylate copolymer 0.2% - 0.25%, carbomer 0.1 - 0.3% and sodium polyacrylate 0.3 - 0.4%; The skin conditioner includes 0.2% - 0.3% allantoin, hydroxyphenyl propanamide benzoic acid 0.02 - 0.03%, purslane extract 1 - 1.5%, pentaerythrityl tetra(bis - tert - butyl hydroxyhydrocinnamate) 0.05% - 0.1%, glabridin 0.001% - 0.02%, resveratrol 0.001% - 0.02%, dimethylmethoxy chromanol 0.001% - 0.02%, diglucosyl gallic acid 0.005% - 0.1%, grape seed extract 0.02% - 0.05%, epigallocatechin gallate 0.0001% - 0.0002% and inositol 0.2% - 0.3%; The pH regulator is 0.03% - 0.04% sodium hydroxide.

2. The smear-type facial mask according to claim 1, wherein It also includes a preservative; and / or, it also includes a colorant; and / or, it also includes a fragrance.

3. The smear-type facial mask according to claim 2, characterized in that, Calculated as a total of 100% by mass percentage, it also includes 0.001% - 3.5% preservative; and / or, it also includes 0.01% - 1.5% colorant; and / or, it also includes 0.1% - 0.5% fragrance.

4. The smear-type facial mask according to claim 3, wherein The preservative includes 1,2 - hexanediol 1% - 1.2%, p - hydroxyacetophenone 0.4% - 0.5%, glycerol caprylate 0.002% - 0.003% and octanoyl hydroxamic acid 0.03% - 0.04%; the colorant includes phellodendron extract 0.07% - 0.08%, caramel color 0.11% - 0.12%, rose extract 0.02% - 0.05% and gardenia fruit extract 0.025 - 0.05%; and / or, the fragrance includes sweet orange oil 0.3% - 0.42%.

5. A preparation method of the smear-type facial mask according to claim 4, characterized in that, It includes the following steps: S1. Heat component A to 80 - 85 °C and keep it warm, then stir, homogenize, dissolve and disperse it; heat component B to 80 - 85 °C and keep it warm, stir, homogenize, dissolve and disperse it, and then mix and homogenize and emulsify component A and component B; S2. Then stir and cool down to 65 - 75 °C, and then add component C and component D in sequence, and stir and homogenize; S3. Cool down to 40 - 45 °C, and continue to add component E, component F and component G; S4. Continue to add component H, and then add component I and stir and homogenize to obtain the smearable facial mask; Component A is obtained by mixing water, glycerol, titanium dioxide, panthenol, sodium polyacrylate grafted starch, carbomer and allantoin; Component B is obtained by mixing triglyceride caprylate / caprate, cetearyl alcohol, cetyl ethylhexanoate, cetearyl glucoside, shea butter, PEG - 100 stearate, glycerol stearates, oat kernel oil, wheat germ oil, pentaerythrityl tetra(bis - tert - butylhydroxyhydrocinnamate), dimethylmethoxy chromanol, resveratrol; Component C is obtained by mixing sodium hydroxide and water; Component D is obtained by mixing bentonite and water; Component E is obtained by mixing inositol and water; Component F is obtained by mixing glabridin and glycerol; Component G is obtained by mixing coenzyme Q10 liposome, diglucosyl gallic acid, tetrahydrocurcumin liposome, grape seed extract and epigallocatechin gallate glucoside; Component H is obtained by mixing lotus extract, citrus peel extract, portulaca extract and hydroxyphenyl propanamide benzoic acid; Component I is sodium acryloyldimethyl taurate / VP copolymer.

6. The preparation method of the smear-type facial mask according to claim 5, characterized in that, Component A also includes water and p - hydroxyacetophenone; and / or, component G also includes 1,2 - hexanediol, glyceryl caprylate and octanoyl hydroxamic acid; and / or, component G also includes sweet orange oil.

7. The preparation method of the smear-type facial mask according to claim 5, wherein In step S4, after adding phase I and stirring and homogenizing, it also includes continuing to add component J, component K, component L and continuing to stir, and then adding component M and stirring to obtain the smearable facial mask; Component J is obtained by mixing phellodendron bark extract and water; Component K is obtained by mixing caramel color and water; Component L is obtained by mixing rose extract and gardenia fruit extract; Component M is obtained by mixing sodium polyacrylate, glycerol and water.

8. The preparation method of the smear-type facial mask according to claim 5, wherein In step S2, before adding component D, it also includes heat - treating component D at 80 - 85 °C.

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