Device for quantitatively analyzing veterinary drug residues in milk
By setting up metal balls and rotating components in the solvent bottle, combined with intermittent toggles and pipe parts, the precipitation problem of milk samples when pumped into the chromatographic column is solved, and the quantitative delivery and accurate quantitative analysis of the samples are achieved.
Patent Information
- Application Number
- CN202510604032.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-12
- Publication Date
- 2025-07-04
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
In the prior art, when the milk sample is pumped into the chromatographic column, the veterinary drug residues are wrapped in the precipitate due to standing precipitation, resulting in difficulty in quantitative analysis.
A quantitative analysis device is designed to realize the rotation and stirring of the solvent bottle by setting up a metal ball and a rotating assembly in the solvent bottle, combining intermittent toggle and pipe parts, avoiding precipitation, and at the same time, the quantitative delivery of the sample is achieved by using the suction pump body and the quantitative component.
It effectively prevents the precipitation of milk samples in the solvent bottle, ensures that the samples are quantitatively transported to the chromatographic column, and realizes accurate quantitative analysis of veterinary drug residues in milk.
Smart Images
Figure CN120254144A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of detection equipment, and particularly to a device for quantitatively analyzing veterinary drug residues in milk. Background Technique
[0002] Milk is an important source of protein. The production and detection of milk products are important links in ensuring food safety. During the feeding process of dairy cows, in order to increase the milk production of dairy cows and promote their healthy growth, certain veterinary drugs need to be fed to the cows. When the cows produce milk, some veterinary drugs will remain.
[0003] In order to ensure the safety of milk, it is necessary to detect the residual veterinary drugs in milk. When detecting the residual veterinary drugs in milk, first, sample collection is carried out, and different amounts and batches of milk are collected. The collected sample milk is processed, including protein precipitation, liquid-liquid extraction, and solid-phase extraction. After the milk sample treatment is completed, the sample is detected by a detection method. A common detection method is to detect by chromatography. When using a high-performance liquid chromatograph for detection, the milk in the sample is pumped into the detection system by a high-pressure pump, then flows into the chromatographic column, and then through repeated absorption and desorption distribution processes, it is separated into individual components and flows out of the chromatographic column in sequence, so as to detect different components. However, since the milk sample is placed in the sample box, during the pumping process by the pump body, due to the static precipitation of milk, the milk sample that has not been pumped into the chromatographic column by the pump body precipitates, resulting in the residual veterinary drugs being wrapped in the precipitate. When the mixed milk samples are pumped in centrally, it is not convenient to quantitatively pump the milk samples into the chromatographic column for separation. For this reason, we have proposed a device for quantitatively analyzing veterinary drug residues in milk. Summary of the Invention
[0004] The purpose of the present invention is to provide a device for quantitatively analyzing veterinary drug residues in milk to solve the problems raised in the above background technique.
[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a device for quantitatively analyzing veterinary drug residues in milk, comprising an inspector and a computer-controlled display screen; a column box for loading a chromatographic column is connected to the top of the inspector, an automatic sampler is connected to the top of the column box, a pump box is provided on the top of the automatic sampler, a suction pump body is provided inside the pump box, a discharge pipe connected to the automatic sampler is provided on the suction pump body, a solvent box is provided on the top of the pump box, a plurality of placement holes are opened on the solvent box, and a solvent bottle is provided inside the placement holes, a metal ball is provided inside the solvent bottle, a rotating assembly for driving the solvent bottle to rotate is connected to the bottom of the solvent box, an intermittent toggle member is installed at the bottom of the rotating assembly, and the intermittent toggle member includes an electromagnetic ball arranged at the bottom of the solvent bottle; a pipeline component is rotatably connected to the solvent bottles on the same horizontal line, the pipeline component converges and is connected to the suction pump body, the pipeline component is provided with a quantitative component, the quantitative component includes a capsule arranged on the pipeline component, and the bottom of the capsule is connected to the suction pump body.
[0006] Preferably, the pipeline component includes a first pipeline and a second pipeline, the first pipeline and the second pipeline are both rotatably connected to the top of the solvent bottle, the first pipeline and the second pipeline are cross-connected with the adjacent second pipeline and the first pipeline respectively, and a buffer body is provided at the cross-connection point, and the buffer body is connected to the suction pump body.
[0007] Preferably, the quantitative component also includes two groups of slide buckles of a first pipe and a second pipe member arranged on the same horizontal line, the capsule is distributed between the two groups of slide buckles, and a plurality of shrinkage folds are distributed on the capsule. The bottom and top of the capsule are provided with guide air tubes, and the guide air tube at the bottom is connected to a transverse tube. The middle part of the transverse tube is connected to a collision body, and the collision body is in contact with the buffer body.
[0008] Preferably, the sliding buckle is in the shape of a letter "U", and the top of the guide airway at the top of the capsule is connected to a limiting sphere.
[0009] Preferably, the rotating assembly includes a motor arranged inside the solvent box, the motor output shaft passes through the solvent box and is connected to a gear disk, the bottom of the placement hole is rotatably connected to a rotating sleeve, the outside of the rotating sleeve is provided with a gear meshing with the gear disk, and the top of the rotating sleeve is connected to the solvent bottle.
[0010] Preferably, a clamping groove is provided at the bottom of the solvent bottle, a clamping block is connected to the top of the rotating sleeve, and the clamping block is clamped in the clamping groove.
[0011] Preferably, a sliding hole is provided in the clamping block, an impact hole is provided in the clamping groove, and the electromagnetic ball moves at the impact hole.
[0012] Preferably, the intermittent toggle member includes an intermittent disk connected to the output shaft of the motor, the intermittent disk is provided with an intermittent slide groove, a sliding ball is provided inside the intermittent slide groove, and one end of the sliding ball is connected to an elastic curved rod, one end of the elastic curved rod passes through a sliding hole, and the end of the elastic curved rod located in the sliding hole is connected to a contact disk.
[0013] Preferably, the intermittent chute is spliced by a plurality of arc segments.
[0014] Compared with the prior art, the present invention has the following beneficial effects: By flushing the milk sample into different solvent bottles, a rotating component is designed at the bottom of the solvent box, so that each solvent bottle can be rotated and separated, thereby preventing the milk sample from settling in the solvent bottle. At the same time, the electromagnetic ball of the intermittent toggle piece controls the movement of the metal ball inside the solvent bottle, which facilitates the stirring of the milk sample inside the solvent bottle. At the same time, the suction pump body extracts the milk sample through the pipeline component. When the suction pump body is drawn out, the air pressure changes, which drives the provided quantitative component to move outside the pipeline component, thereby facilitating the quantitative movement of the milk sample to the automatic sampler, which is beneficial for quantitatively extracting the milk sample into the chromatographic column inside the column box, and further conducive to quantitative analysis of the veterinary drug retention in the milk sample. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the overall back structure of the present invention; Figure 3 It is a schematic diagram of the partial explosion structure of the present invention; Figure 4 It is a schematic diagram of the partial cutaway structure of the bottom of the solvent box of the present invention; Figure 5 for Figure 4 Schematic diagram of the structure after the solvent tank is removed; Figure 6 It is a schematic diagram of the partial cutaway structure of the solvent bottle; Figure 7 A structural schematic diagram of the rotating assembly of the present invention is shown; Figure 8 It is a structural schematic diagram of the intermittent toggle member of the present invention; Figure 9 It is a schematic diagram of the structure of the solvent bottle and the quantitative component; Figure 10 It is a schematic diagram of the structure of the solvent box; Figure 11 for Figure 7 A schematic diagram of the enlarged structure of the area at center A; Figure 12 for Figure 9 A schematic diagram of the enlarged structure of the area at B in the middle; Figure 13 for Figure 9 Schematic diagram of the enlarged structure of the area C in the middle.
[0016] In the figure: 1-inspector; 2-suction pump body; 3-solvent bottle; 4-metal ball; 5-rotating assembly; 6-intermittent toggle member; 7-pipeline component; 8-quantitative component; 11-computer control display screen; 12-column box; 13-automatic sampler; 14-pump box; 15-solvent box; 16-placing hole; 21-discharge pipe; 31-clamping groove; 32-impact hole; 51-motor; 52-toothed disc; 53-rotating sleeve; 54-gear; 55-clamping block; 56-sliding hole; 61-electromagnetic ball; 62-intermittent disc; 63-intermittent slide groove; 64-sliding ball; 65-elastic curved rod; 66-contact disc; 71-buffer body; 72-first pipeline; 73-second pipeline; 81-capsule; 82-slide buckle; 83-guide air tube; 84-cross tube; 85-collision body; 86-limiting ball. DETAILED DESCRIPTION
[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0018] See also Figures 1 - 13 The present invention provides a technical solution: a device for quantitatively analyzing veterinary drug residues in milk, which solves the problem that when monitoring veterinary drugs in milk samples, after the milk is left to stand, the precipitate wraps the milk and veterinary drug residues, which easily blocks the transmission pipeline, making it difficult to quantitatively check the veterinary drugs remaining in the milk. Figure 1 and attached Figure 2 As shown in, from top to bottom, there are a solvent box 15, a pump box 14, an automatic sampler 13, a column box 12 and an inspector 1, and pads are installed between each component, including an inspector 1 and a computer-controlled display screen 11; the top of the inspector 1 is connected to a column box 12 for loading a chromatographic column, and the top of the column box 12 is connected to an automatic sampler 13, and the top of the automatic sampler 13 is provided with a pump box 14, and a suction pump body 2 is provided inside the pump box 14, and a discharge pipe 21 connected to the automatic sampler 13 is provided on the suction pump body 2, and a solvent box 15 is provided on the top of the pump box 14, and a plurality of placement holes 16 are opened on the solvent box 15, and a solvent bottle 3 is provided inside the placement hole 16. After the milk sample is prepared, the prepared milk sample is treated by ultrasound or the like, and then the sample is filled into the solvent bottle 3, and then the solvent bottle 3 is placed inside the placement hole 16; In order to prevent the milk sample from settling, a metal ball 4 is arranged inside the solvent bottle 3, a rotating assembly 5 for driving the solvent bottle 3 to rotate is connected to the bottom of the solvent box 15, an intermittent toggle member 6 is installed at the bottom of the rotating assembly 5, and the intermittent toggle member 6 includes an electromagnetic ball 61 arranged at the bottom of the solvent bottle 3; when the intermittent toggle member 6 is intermittently toggled, the electromagnetic ball 61 absorbs or impacts the metal ball 4, so that the metal ball 4 rotates inside the solvent bottle 3, so that the milk sample is stirred inside the solvent bottle 3, thereby preventing the milk sample from forming precipitation inside the solvent bottle 3; For the milk sample suction tube, as attached Figure 4 , Attachment Figure 5 and attached Figure 9 As shown in the figure, the solvent bottle 3 on the same horizontal line is rotatably connected with a pipeline component 7, and the pipeline component 7 converges and is connected to the suction pump body 2. The pipeline component 7 includes a first pipeline 72 and a second pipeline 73, and the first pipeline 72 and the second pipeline 73 are both rotatably connected to the top of the solvent bottle 3. The first pipeline 72 and the second pipeline 73 are cross-connected with the adjacent second pipeline 73 and the first pipeline 72, respectively, and a buffer body 71 is provided at the cross-connected position, and the buffer body 71 is connected with the suction pump body 2. After the suction pump body 2 is started, the suction force generated by the suction pump body 2 extracts the sample milk and solvent in the solvent bottle 3 through the first pipeline 72 and the second pipeline 73, and then discharges them into the automatic sampler 13 through the discharge pipe 21. The automatic sampler 13 is an intelligent and automated sampling instrument. It only needs to set the sampling parameters and put in the sample to be tested to complete the automatic sampling process. Generally speaking, the automatic sampler includes a sampling arm, a sampling needle, a sample tray, a cleaning system, a driving system, and a control system. The various parts work closely together to drive the normal operation of the automatic sampler. The injection arm is loaded with an injection needle, and different sample stations are evenly distributed at different radii on a circular sample tray with its rotating axis as the center; the injection arm and the sample tray produce a coordinated injection action after receiving the control instruction and signal; each time the sample tray rotates a sample station, a signal is generated, and the injection arm can perform the sample suction action only after receiving the signal, thereby ensuring that the injection needle on the injection arm can accurately absorb the target sample at different radii of the sample tray. Because the automatic sampler 13 is a prior art feature, the attached drawings in this scheme are used for specific explanation.
[0019] For quantitative extraction, refer to the attached Figure 4 , Attachment Figure 5 and attached Figure 9As shown in , the pipeline component 7 is provided with a quantitative component 8, and the quantitative component 8 includes a capsule 81 arranged on the pipeline component 7, and the bottom of the capsule 81 is connected to the suction pump body 2. The quantitative component 8 also includes two groups of slide buckles 82 of the first pipeline 72 and the second pipeline 73 arranged on the same horizontal line, and the capsule 81 is distributed between the two groups of slide buckles 82. There are multiple shrinkage folds distributed on the capsule 81. The bottom and top of the capsule 81 are provided with a guide air tube 83, and the guide air tube 83 at the bottom is connected to a transverse tube 84. The middle part of the transverse tube 84 is connected to a collision body 85, and the collision body 85 is in contact with the buffer body 71. The slide buckle 82 is 8-shaped, and the top of the guide air tube 83 at the top of the capsule 81 is connected to a limiting sphere 86.
[0020] In order to facilitate the stirring of the milk sample, refer to the attached Figure 7 As shown in , the rotating assembly 5 includes a motor 51 arranged inside the solvent box 15, the output shaft of the motor 51 passes through the solvent box 15 and is connected to a toothed disc 52, the bottom of the placement hole 16 is rotatably connected to a rotating sleeve 53, the outside of the rotating sleeve 53 is provided with a gear 54 meshing with the toothed disc 52, and the top of the rotating sleeve 53 is in contact with the solvent bottle 3, the bottom of the solvent bottle 3 is provided with a snap-in groove 31, the top of the rotating sleeve 53 is connected to a snap-in block 55, and the snap-in block 55 is snap-into the inside of the snap-in groove 31.
[0021] After the milk sample is cultivated, the solvent bottle 3 is inserted into the placement hole 16, and then the clamping block 55 is aligned with the clamping groove 31, so that the solvent bottle 3 can be stably placed at the placement hole 16. When the motor 51 is started, the motor 51 drives the gear plate 52 to rotate. Because the gear plate 52 and the gear 54 are engaged, the gear 54 is driven to rotate. Because the gear 54 is fixed to the outside of the rotating sleeve 53, and because the rotating sleeve 53 is rotatably connected to the bottom position of the solvent box 15, it is easy to drive different solvent bottles 3 to rotate, and then shake different solvents and samples to prevent the milk sample from standing still.
[0022] In order to fully mix the sample in the solvent bottle 3, a sliding hole 56 is provided in the clamping block 55, an impact hole 32 is provided in the clamping groove 31, and the electromagnetic ball 61 moves at the impact hole 32. The intermittent toggle member 6 includes an intermittent disk 62 connected to the output shaft of the motor 51, an intermittent slide 63 is provided on the intermittent disk 62, a sliding ball 64 is provided inside the intermittent slide 63, and an elastic curved rod 65 is connected to one end of the sliding ball 64, one end of the elastic curved rod 65 passes through the sliding hole 56, and a contact disk 66 is connected to one end of the elastic curved rod 65 located in the sliding hole 56. The intermittent slide 63 is spliced by a plurality of arc segments.
[0023] When the suction pump body 2 sucks, milk samples are sucked from the first pipeline 72 and the second pipeline 73, and at the same time, the motor 51 is started. After the motor 51 is started, the motor 51 drives the gear disk 52 to rotate. Since the gear disk 52 meshes with the gear 54, the gear 54 is driven to rotate. Since the gear 54 is fixed outside the rotating sleeve 53, and since the rotating sleeve 53 is rotatably connected to the bottom position of the solvent tank 15, it is convenient to drive different solvent bottles 3 to rotate, and then different solvents and samples are shaken evenly to avoid the milk samples from standing still. When the suction pump body 2 sucks, the suction pump body 2 sucks excess air, and the excess air sucked converges at the intersection of the first pipeline 72 and the second pipeline 73, so that the collision body 85 bulges. Since the collision body 85 contacts the cross bar 84, the excess air is guided along the guide air pipe 83. Since the bladder 81 is fixed to the guide air pipe 83, the bladder 81 is caused to expand and transform. Since the sliding buckle 82 is installed on the bladder 81 and the sliding buckle 82 is in an 8-shaped configuration, it is convenient for stable sliding. At the same time, a conical outer sleeve is provided on the sliding buckle 82, so that when the sliding buckle 82 slides, it is convenient for the samples in the first pipeline 72 and the second pipeline 73 to flow, and thus the samples are quantitatively sucked into the suction pump body 2. Then, the discharge pipe 21 installed on the suction pump body 2 discharges the sucked samples to the auto sampler 13. Through the automatic discharge function of the auto sampler 13, the samples are introduced into the chromatographic column to form different electrical signals, and then different graphs are formed by the detector 1 and displayed on the computer control display screen 11, so as to facilitate the analysis of the residues in the milk.
[0024] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.
[0025] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. An apparatus for quantitatively analyzing veterinary drug residues in milk, comprising an inspector (1) and a computer control display screen (11); characterized in that: The top of the inspector (1) is connected to a column box (12) for loading a chromatographic column, the top of the column box (12) is connected to an automatic sampler (13), the top of the automatic sampler (13) is provided with a pump box (14), the pump box (14) is provided with a suction pump body (2), the suction pump body (2) is provided with a discharge pipe (21) connected to the automatic sampler (13), the top of the pump box (14) is provided with a solvent box (15), the solvent box (15) is provided with a plurality of placement holes (16), and the placement holes (16) are provided with solvent bottles (3), the solvent bottles (3) are provided with metal balls (4), the bottom of the solvent box (15) is connected to a rotating assembly (5) for driving the solvent bottle (3) to rotate, the bottom of the rotating assembly (5) is installed with an intermittent toggle member (6), the intermittent toggle member (6) comprises an electromagnetic ball (61) arranged at the bottom of the solvent bottle (3); A pipe component (7) is rotatably connected to the solvent bottles (3) on the same horizontal line. The pipe component (7) converges and is connected to the suction pump body (2). The pipe component (7) is provided with a quantitative component (8). The quantitative component (8) includes a capsule (81) arranged on the pipe component (7). The bottom of the capsule (81) is in communication with the suction pump body (2).
2. The device for quantitatively analyzing veterinary drug residues in milk according to claim 1, wherein: The pipeline component (7) comprises a first pipeline (72) and a second pipeline (73), wherein the first pipeline (72) and the second pipeline (73) are both rotatably connected to the top of the solvent bottle (3), and the first pipeline (72) and the second pipeline (73) are cross-connected with the adjacent second pipeline (73) and the first pipeline (72) respectively, and a buffer body (71) is provided at the cross-connection point, and the buffer body (71) is connected to the suction pump body (2).
3. The device for quantitatively analyzing veterinary drug residues in milk according to claim 2, wherein: The quantitative component (8) further comprises two groups of slide buckles (82) of a first pipe (72) and a second pipe (73) arranged on the same horizontal line; the capsule (81) is distributed between the two groups of slide buckles (82); a plurality of shrinkage folds are distributed on the capsule (81); a guide air tube (83) is provided at the bottom and the top of the capsule (81); the guide air tube (83) at the bottom is connected to a transverse tube (84); a collision body (85) is connected to the middle portion of the transverse tube (84); and the collision body (85) is in contact with the buffer body (71).
4. A device for quantitatively analyzing veterinary drug residues in milk according to claim 3, characterized in that: The sliding buckle (82) is in the shape of a figure 8, and the top of the guide air tube (83) at the top of the capsule (81) is connected to a limiting sphere (86).
5. The device for quantitatively analyzing veterinary drug residues in milk according to claim 1, characterized in that: The rotating assembly (5) comprises a motor (51) arranged inside the solvent box (15); an output shaft of the motor (51) passes through the solvent box (15) and is connected to a toothed disc (52); a rotating sleeve (53) is rotatably connected to the bottom of the placement hole (16); a gear (54) meshing with the toothed disc (52) is provided on the outside of the rotating sleeve (53); and a top of the rotating sleeve (53) is in contact with the solvent bottle (3).
6. The device for quantitatively analyzing veterinary drug residues in milk according to claim 5, characterized in that: The bottom of the solvent bottle (3) is provided with a clamping groove (31), the top of the rotating sleeve (53) is connected with a clamping block (55), and the clamping block (55) is clamped inside the clamping groove (31).
7. The device for quantitatively analyzing veterinary drug residues in milk according to claim 6, characterized in that: A sliding hole (56) is provided in the clamping block (55), an impact hole (32) is provided in the clamping groove (31), and the electromagnetic ball (61) moves at the impact hole (32).
8. The device for quantitatively analyzing veterinary drug residues in milk according to claim 7, characterized in that: The intermittent toggle member (6) comprises an intermittent disk (62) connected to the output shaft of the motor (51), the intermittent disk (62) being provided with an intermittent slide groove (63), a sliding ball (64) being provided inside the intermittent slide groove (63), one end of the sliding ball (64) being connected to an elastic curved rod (65), one end of the elastic curved rod (65) passing through the sliding hole (56), and one end of the elastic curved rod (65) located in the sliding hole (56) being connected to a contact disk (66).
9. The device for quantitatively analyzing veterinary drug residues in milk according to claim 8, wherein: The intermittent chute (63) is composed of a plurality of arc segments.