Control method and system for preventing confusion in cell culture

Abstract

The invention discloses an anti-confusion control method and system for cell culture, and the method comprises the steps: obtaining cell information, processing the cell information to obtain a corresponding identification code, processing and generating verification information between the cell information and the identification code, and storing the verification information; scanning the identification code to obtain identification information and sending the identification information to the control terminal; the control terminal receives the identification information and matches the identification information with the verification information, if so, an unlocking signal is generated, if not, a feedback signal is generated, and meanwhile, a log is generated and stored; the lock receives the unlocking signal for unlocking; the system comprises lock assemblies, identification terminals and a control terminal, the multiple identification terminals are wirelessly connected with the control terminal to realize data interaction, the control terminal is in control connection with the multiple lock assemblies, and each incubator is provided with the lock assembly; the identification terminal is used for scanning the identification code and generating identification information; the control terminal is used for matching the identification information with the verification information, generating an unlocking signal if the identification information is matched with the verification information, and generating a feedback signal if the identification information is not matched with the verification information.

Description

Technical Field

[0001] The present invention relates to the field of unlocking methods and systems for cell incubators, and particularly to a control method and system for preventing confusion in cell culture. Background Art

[0002] In fields such as cell therapy, stem cell therapy, or gene therapy, a large number of different types of cell cultures are usually involved. During the cell culture process, especially in personalized cell therapy fields such as CAR-T, CAR-NK, TIL, TCR-T, etc., cells from multiple patient sources often need to be cultured simultaneously. Traditional incubator door opening control methods are mostly manual operations or simple password lock controls, which have the following problems:

[0003] 1. Risk of cell confusion: When cells from multiple patients or multiple types of cells are cultured simultaneously, manual operation is prone to incorrect cell retrieval. Especially when there are a large number of incubators, operators may confuse cells from different patients or different types of cells.

[0004] 2. Insufficient security: Simple password lock control cannot ensure that only authorized personnel can open the incubator, posing a risk of cells being misappropriated or abused.

[0005] 3. Complicated operation: The process of manually recording and verifying patient information and incubator information is cumbersome, increasing the workload of operators.

[0006] To solve the above problems, a cell incubator unlocking system based on identification code matching is proposed. By using identification code matching technology, it is ensured that only authorized personnel can open the corresponding incubator, preventing cell confusion and abuse, and managing the cell bank more safely and efficiently. Summary of the Invention

[0007] The technical problems to be solved by the present invention are as follows: the risk of confusion in existing cell operations: when culturing cells from multiple patients or multiple types of cells simultaneously, manual operations are prone to incorrect cell handling; insufficient security: simple password lock control cannot ensure that only authorized personnel can open the incubator, and there is a risk of cells being misappropriated or abused; cumbersome operations: the process of manually recording and verifying patient information and incubator information is cumbersome, increasing the workload of operators. The present invention provides a control method for preventing confusion in cell culture and also provides a control system for preventing confusion in cell culture, which can prevent cell mix-ups: through identification code matching technology, it ensures that only authorized personnel can open the corresponding incubator and prevent incorrect cell handling; improve security: the identification code matching verification process is automated, reducing the risk of human operation errors and abuse; simple operation: operators only need to scan the identification code to complete the unlocking operation, simplifying the work process and improving work efficiency; record traceability: the control system records the operation logs of each unlocking and locking, facilitating traceability and management, to solve the defects caused by the prior art.

[0008] To solve the above technical problems, the present invention provides the following technical solutions:

[0009] In a first aspect, a control method for preventing confusion in cell culture, which includes the following steps:

[0010] Obtain cell information and process it to obtain a corresponding identification code according to the cell information, and process and generate verification information between the cell information and the identification code, and store the cell information, the verification information, and the identification code;

[0011] Scan the identification code to obtain identification information and send it to the control terminal;

[0012] The control terminal receives the identification information and matches it with the verification information. If they match, an unlocking signal is generated. If they do not match, a feedback signal is generated, and at the same time, a log is generated for storage;

[0013] The lock receives the unlocking signal to unlock.

[0014] In the above control method for preventing confusion in cell culture, the cell information includes a patient's unique biological identifier, a cell type identifier, production quality control data, and treatment-related information.

[0015] In the above control method for preventing confusion in cell culture, the patient's unique biological identifier includes at least one of a patient number, name, age, hospital admission number, ID card, etc.;

[0016] The cell type identifier includes at least one of CAR-T cells, hematopoietic stem cells, iPSC-derived cells;

[0017] Production quality control data, including at least one of cell viability, purity test results and batch traceability code;

[0018] Treatment-related information includes at least one of indication type, clinical stage, and treatment regimen number.

[0019] In the above-mentioned control method for preventing confusion in cell culture, the identification code is a QR code, a bar code or an RFID tag.

[0020] In a second aspect, a control system for preventing confusion in cell culture is characterized in that it comprises a lock component, an identification terminal, and a control terminal, wherein a plurality of the identification controls establish a connection with the control terminal via wireless to realize data interaction, the control terminal controls the connection of a plurality of the lock components, and each incubator is equipped with the lock component;

[0021] The identification terminal is used to scan the identification code and generate identification information;

[0022] The control terminal is used to receive the identification information and pre-input cell information, verification information, and identification code, and is also used to match the identification information with the verification information, and to generate an unlocking signal if they match, and to generate a feedback signal if they do not match, and to generate a log for storage;

[0023] The lock component receives the unlocking signal to unlock the lock.

[0024] In the above-mentioned control system for preventing confusion in cell culture, the identification terminal includes a barcode scanner or an RFID reader / writer.

[0025] In the above-mentioned control system for preventing confusion in cell culture, the identification code is a QR code, a bar code or an RFID tag.

[0026] The above-mentioned control system for preventing confusion in cell culture is used in scenarios and fields such as autologous CAR-T cell therapy, hematopoietic stem cell gene therapy, and iPSC-derived cell therapy that require full-process prevention of confusion.

[0027] In a third aspect, a chip comprises: a processor for calling and running a computer program from a memory, so that a device equipped with the chip executes: the method in the first aspect.

[0028] According to a fourth aspect, a computer program product comprises computer program instructions, wherein the computer program instructions enable a computer to execute the method according to the first aspect.

[0029] The above-mentioned method and system for unlocking a cell incubator based on identification code matching relate to the fields of biomedicine, biotechnology, and medical device equipment. The system includes a lock assembly, a control terminal, and an identification terminal of the incubator. Through the identification code matching technology, it is ensured that only authorized personnel can open the corresponding incubator, preventing cell confusion and abuse. This solution is mainly used in personalized treatment fields such as cell therapy, and can also be extended to other biomedical fields that require strict sample differentiation. The system is easy to operate and has high safety, which can effectively prevent the wrong taking and abuse of cells, and record operation logs for traceability and management.

[0030] According to the technical solution provided by the control method and system for preventing cell confusion of the present invention, the following technical effects are achieved:

[0031] Prevent cell disorder: Through the identification code matching technology, it is ensured that only authorized personnel can open the corresponding incubator, preventing the wrong taking of cells; Improve safety: The identification code matching verification process is automated, reducing the risk of human operation errors and abuse; Easy to operate: The operator only needs to scan the identification code to complete the unlocking operation, simplifying the work process and improving work efficiency; Records traceable: The control system records the operation logs of each unlocking and locking, which is convenient for traceability and management. Brief Description of the Drawings

[0032] Figure 1 It is a flowchart of a control method for preventing cell confusion in cell culture;

[0033] Figure 2 It is a schematic structural diagram of a control system for preventing cell confusion in cell culture;

[0034] Figure 3 It is an operation flowchart of a control system for preventing cell confusion in cell culture.

[0035] Among them, the reference numerals are as follows:

[0036] Lock assembly 1, identification terminal 2, control terminal 3. Detailed Embodiments

[0037] In order to make the technical means, creative features, achieved purposes, and functions of the invention easy to understand, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with specific drawings. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments.

[0038] All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of protection of the present invention.

[0039] It should be noted that the structures, proportions, sizes, etc. shown in the drawings of this specification are only used to cooperate with the content disclosed in the specification for those familiar with this technology to understand and read, and are not used to limit the conditions under which the present invention can be implemented. Therefore, they do not have substantial technical significance. Any modification of the structure, change in the proportional relationship, or adjustment of the size, without affecting the effects that the present invention can produce and the purposes that can be achieved, should still fall within the scope covered by the technical content disclosed in the present invention.

[0040] At the same time, the terms such as "upper", "lower", "left", "right", "middle", and "one" cited in this specification are only for the convenience of clear narration and are not used to limit the scope in which the present invention can be implemented. The change or adjustment of their relative relationships, without substantial change in the technical content, should also be regarded as the scope in which the present invention can be implemented.

[0041] The first embodiment of the present invention provides a control method for preventing confusion in cell culture, and the second embodiment provides a control system for preventing confusion in cell culture. The purpose is to prevent cell confusion: through identification code matching technology, it is ensured that only authorized personnel can open the corresponding incubator to prevent wrong cell taking; improve safety: the identification code matching verification process is automated, reducing the risk of human operation errors and abuse; easy to operate: the operator only needs to scan the identification code to complete the unlocking operation, simplifying the work process and improving work efficiency; records are traceable: the control system records the operation logs of each unlocking and locking, facilitating traceability and management.

[0042] As Figure 1 shown, in the first aspect, the first embodiment, a control method for preventing confusion in cell culture, wherein, it includes the following steps:

[0043] Obtain cell information and process it to obtain the corresponding identification code according to the cell information, and process and generate verification information between the cell information and the identification code, and store the cell information, verification information, and identification code;

[0044] Scan the identification code to obtain identification information and send it to the control terminal 3;

[0045] The control terminal 3 receives the identification information and matches it with the verification information. If they match, an unlocking signal is generated. If they do not match, a feedback signal is generated, and at the same time, a log is generated for storage;

[0046] The lock receives the unlocking signal and unlocks.

[0047] In the above-mentioned control method for preventing confusion in cell culture, the cell information includes the patient's unique biological identifier, cell type identifier, production quality control data, and treatment-related information.

[0048] The above control method for preventing confusion in cell culture is characterized in that the patient's unique biological identifier includes at least one of the patient number, name, age, hospital admission number, ID card, etc.;

[0049] The cell type identifier includes at least one of CAR-T cells, hematopoietic stem cells, and iPSC-derived cells;

[0050] The production quality control data includes at least one of cell viability, purity test results, and batch traceability code;

[0051] The treatment-related information includes at least one of the indication type, clinical stage, and treatment plan number.

[0052] The above control method for preventing confusion in cell culture, wherein the identification code is a two-dimensional code or a barcode or an RFID tag.

[0053] As Figure 2 shown, in the second aspect, the second embodiment, a control system for preventing confusion in cell culture is characterized in that it includes a lock assembly 1, an identification terminal 2, and a control terminal 3. Multiple identification controls create connections with the control terminal 3 wirelessly to achieve data interaction. The control terminal 3 controls and connects multiple lock assemblies 1, and a lock assembly 1 is installed on each incubator;

[0054] The identification terminal 2 is used to scan the identification code and generate identification information;

[0055] The control terminal 3 is used to receive the identification information, as well as the pre-entered cell information, verification information, and identification code. It is also used to match the identification information with the verification information. If they match, an unlocking signal is generated. If they do not match, a feedback signal is generated, and at the same time, a log is generated for storage;

[0056] The lock assembly 1 receives the unlocking signal to unlock;

[0057] Install a lock assembly 1 on each incubator to control the opening and closing of the incubator door lock; install a visible control terminal 3 on the computer to monitor the status of the incubator in real time; install an identification terminal 2 and connect it to the control terminal 3, which can identify a specific identification code and transmit the identification information to the control terminal 3; Identification code generation: Generate a unique identification code for each patient to identify their cell information; Cells are placed in the incubator: The operator uses the identification terminal 2 to scan the patient's identification code. After the control terminal 3 verifies successfully, the incubator door lock is opened. The operator places the cells in the incubator and then manually closes the incubator door lock; Cell retrieval: The operator uses the identification terminal 2 to scan the patient's identification code. After the control terminal 3 verifies, the incubator door lock is opened. After the operator takes out the cells, then manually closes the incubator door lock.

[0058] In the above-mentioned control system for preventing confusion in cell culture, the identification terminal 2 includes a barcode scanner or an RFID reader / writer.

[0059] In the above-mentioned control system for preventing confusion in cell culture, the identification code is a QR code, a bar code or an RFID tag.

[0060] The above-mentioned control system for preventing confusion in cell culture is used in scenarios and fields such as autologous CAR-T cell therapy, hematopoietic stem cell gene therapy, and iPSC-derived cell therapy that require full-process prevention of confusion.

[0061] like Figure 3 As shown, during the specific operation, the cells are placed in the incubator:

[0062] (1) The operator uses the identification terminal 2 to scan the patient's unique identification code;

[0063] (2) The control terminal 3 verifies the identification code information, and after confirming the authority, sends an unlocking signal, and the incubator door lock is opened;

[0064] (3) After the operator places the cells into the incubator, he / she manually locks the control system to ensure that the incubator door is closed.

[0065] Cell collection:

[0066] (1) The operator uses the identification terminal 2 to scan the patient's unique identification code;

[0067] (2) The control terminal 3 verifies the identification code information, and after confirming the authority, sends an unlocking signal, and the incubator door lock is opened;

[0068] (3) After the operator takes the cells, he / she manually locks the control system to ensure that the incubator door is locked.

[0069] Application scenarios: The system is mainly used for cell culture in personalized treatment fields such as cell therapy, ensuring that each patient's cells can only be cultured in their own incubator. The system can also be expanded to other biomedical fields that require strict distinction of samples, such as stem cell culture, gene therapy, etc.

[0070] In a third aspect, a chip comprises: a processor for calling and running a computer program from a memory, so that a device equipped with the chip executes: the method in the first aspect.

[0071] According to a fourth aspect, a computer program product comprises computer program instructions, wherein the computer program instructions enable a computer to execute the method according to the first aspect.

[0072] For example, the memory may include random access memory, flash memory, read-only memory, programmable read-only memory, non-volatile memory, registers, etc.;

[0073] The processor may be a central processing unit (CPU) or the like, or a graphics processing unit (GPU). The memory may store executable instructions;

[0074] The processor may execute the executable instructions stored in the memory, thereby implementing the various processes described herein.

[0075] It can be understood that the memory in this embodiment may be volatile memory or non-volatile memory, or may include both volatile and non-volatile memory;

[0076] Among them, the non-volatile memory may be ROM (Read-Only Memory), PROM (Programmable ROM), EPROM (Erasable PROM), EEPROM (Electrically EPROM), or flash memory.

[0077] The volatile memory may be RAM (Random Access Memory), which is used as an external cache;

[0078] By way of example but not limitation, many forms of RAM are available, such as SRAM (Static RAM), DRAM (Dynamic RAM), SDRAM (Synchronous DRAM), DDR SDRAM (Double Data Rate SDRAM), ESDRAM (Enhanced SDRAM), SLDRAM (Synchlink DRAM), and DRRAM (Direct Rambus RAM). The memory described herein is intended to include but not be limited to these and any other suitable types of memory.

[0079] In some embodiments, the memory stores the following elements, an upgrade package, an executable unit, or a data structure, or a subset thereof, or an extended set thereof: an operating system and an application program;

[0080] Among them, the operating system includes various system programs, such as the framework layer, the core library layer, the driver layer, etc., which are used to implement various basic services and handle hardware-based tasks;

[0081] The application programs include various application programs, which are used to implement various application services. The program for implementing the method of the embodiment of the present invention may be included in the application programs.

[0082] Those skilled in the art can understand that the units and algorithm steps of each example described in combination with the embodiments disclosed in this article can be implemented by electronic hardware, or a combination of software and electronic hardware;

[0083] Whether these functions are implemented in a hardware or software manner depends on the specific application and design constraints of the technical solution;

[0084] Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered to exceed the scope of this application.

[0085] In the embodiments of the present application, the disclosed systems, devices and methods can be implemented in other ways;

[0086] For example, the division of units or modules is only a logical function division, and there may be other division methods in actual implementation;

[0087] For example, multiple units, modules or components can be combined or integrated into another system;

[0088] In addition, each functional unit or module in the embodiments of the present application can be integrated in a processing unit or module, or can be a separate physical existence, etc.

[0089] It should be understood that in various embodiments of the present application, the size of the serial numbers of each process does not mean the order of execution, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present application.

[0090] If the described function is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a machine-readable storage medium;

[0091] Therefore, the technical solution of the present application can be embodied in the form of a software product, which can be stored in a machine-readable storage medium, and it can include several instructions to enable an electronic device to execute all or part of the process of the technical solution described in the embodiments of the present application;

[0092] The above storage medium may include various media that can store program codes, such as ROM, RAM, removable disks, hard disks, magnetic disks or optical disks.

[0093] In summary, the present invention can prevent cell disorder: through the identification code matching technology, it ensures that only authorized personnel can open the corresponding incubator, preventing the wrong cells from being taken; improve safety: the identification code matching verification process is automated, reducing the risk of human operation errors and abuse; easy to operate: the operator only needs to scan the identification code to complete the unlocking operation, simplifying the work process and improving work efficiency; records are traceable: the control system records the operation logs of each unlocking and locking, facilitating traceability and management.

[0094] The specific embodiments of the invention have been described above. It should be understood that the invention is not limited to the above specific embodiments, and the devices and structures not described in detail should be understood to be implemented in a common manner in the art; those skilled in the art can make various deformations or modifications within the scope of the claims, making several simple deductions, deformations or substitutions, which do not affect the essence of the invention.

Claims

1. A control method for preventing confusion in cell culture, characterized in that, It includes the following steps: Obtain cell information, process it according to the cell information to obtain a corresponding identification code, process and generate verification information between the cell information and the identification code, and store the cell information, the verification information, and the identification code; Scan the identification code to obtain identification information and send it to the control terminal; The control terminal receives the identification information and matches it with the verification information. If they match, an unlocking signal is generated. If they do not match, a feedback signal is generated, and at the same time, a log is generated for storage; The lock receives the unlocking signal to unlock.

2. The control method for preventing confusion in cell culture according to claim 1, characterized in that, The cell information includes at least one of a patient's unique biological identifier, a cell type identifier, production quality control data, and treatment-related information.

3. The control method for preventing confusion in cell culture according to claim 2, characterized in that, The patient's unique biological identifier includes at least one of a patient number, name, age, hospital admission number, ID card, etc.; The cell type identifier includes at least one of CAR-T cells, hematopoietic stem cells, and iPSC-derived cells; The production quality control data includes at least one of cell viability, purity test results, and batch traceability codes; The treatment-related information includes at least one of an indication type, a clinical stage, and a treatment plan number.

4. The control method for preventing confusion in cell culture according to claim 1, characterized in that, The identification code is a QR code, a barcode, or an RFID tag.

5. A control system for preventing confusion in cell culture, characterized in that, It includes a lock assembly, an identification terminal, and a control terminal. Multiple identification controls are wirelessly connected to the control terminal to achieve data interaction. The control terminal controls and connects multiple lock assemblies, and each incubator is equipped with the lock assembly; The identification terminal is used to scan the identification code and generate identification information; The control terminal is used to receive the identification information, as well as the pre-entered cell information, verification information, and identification code. It is also used to match the identification information with the verification information. If they match, an unlocking signal is generated. If they do not match, a feedback signal is generated, and at the same time, a log is generated for storage; The lock assembly receives the unlocking signal to unlock.

6. A control system for preventing confusion in cell culture according to claim 5, characterized in that, The identification terminal includes a barcode scanner or an RFID reader / writer.

7. A control system for preventing confusion in cell culture according to claim 5, characterized in that, The identification code is a QR code, a barcode, or an RFID tag.

8. A chip, characterized in that, It includes: A processor for calling and running a computer program from a memory, so that the device installed with the chip executes: the method according to any one of claims 1-3.

9. A computer program product, characterized in that, It includes computer program instructions that cause a computer to execute the method according to any one of claims 1-3.

10. A control system for preventing confusion in cell culture according to any one of claims 5-7, which is used in whole-process anti-confusion scenarios and fields such as autologous CAR-T cell therapy, hematopoietic stem cell gene therapy, and iPSC-derived cell therapy.

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