Traditional Chinese medicine composition for treating hepatopathy as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating hepatopathy, which at least comprises the following components in parts by weight: 10-14g of salvia miltiorrhiza, 10-12g of peach kernel, 10-12g of madder, 13-17g of herba lycopi, 13-17g of polygonum cuspidatum, 10-12g of pulp of dogwood fruit, 5-7g of schisandra chinensis, 27-33g of sedum sarmentosum, 27-33g of bighead atractylodes rhizome and 10-14g of rhizoma alismatis. The preparation method of the traditional Chinese medicine composition for treating hepatopathy comprises the following steps: mixing the raw materials, adding 400ml of clear water, boiling with strong fire, continuously decocting for 30 minutes, filtering and extracting liquid medicine; adding 400ml of clear water into medicine residues, boiling with strong fire, continuing to decoct for 30 minutes, filtering and extracting medicine liquid; and combining the medicine liquid extracted twice. The traditional Chinese medicine composition for treating hepatopathy is used for treating blood stasis and collateral obstruction, toxin stagnation and dampness stagnation, dysfunction of spleen transportation and liver yin deficiency type fatty liver hepatitis, and has the effects of activating blood and detoxifying, activating spleen and promoting urination, and nourishing yin and nourishing liver.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for treating liver diseases, a preparation method thereof and an application thereof. Background Art

[0002] Chronic liver diseases, such as chronic hepatitis B, fatty liver hepatitis, alcoholic liver disease, drug-induced hepatitis, autoimmune liver disease, early liver cirrhosis, etc., which are characterized by blood stasis blocking collaterals, toxin binding with dampness stagnation, spleen transportation disorder, and liver yin deficiency. The symptoms include distending pain in both flanks, abdominal discomfort, dizziness, fatigue, weakness, bitter taste in the mouth, blurred vision, frequent sighing or irritability, poor sleep, heaviness in the limbs or mild edema in the lower limbs, irregular bowel movements, liver function insufficiency. In women, there are often irregular menstruation, dark menstrual color, and blood clots. The tongue is purplish or has ecchymosis, the tongue coating is thin and greasy, and the pulse is stringy and thready or stringy and unsmooth.

[0003] For such diseases, there is a lack of effective traditional Chinese medicine formulas for symptomatic treatment in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating liver diseases, a preparation method thereof and an application thereof, which can treat fatty liver hepatitis with blood stasis blocking collaterals, toxin binding with dampness stagnation, spleen transportation disorder, and liver yin deficiency, and has the effects of promoting blood circulation to remove toxins, promoting spleen transportation and promoting diuresis, and nourishing yin and softening the liver.

[0005] To solve the above technical problems, the present invention specifically provides the following technical solutions:

[0006] The present invention provides a traditional Chinese medicine composition for treating liver diseases. Calculated by weight, the formula of the traditional Chinese medicine composition at least includes:

[0007] Salvia miltiorrhiza 10 - 14 g, Prunus persica 10 - 12 g, Rubia cordifolia 10 - 12 g, Eupatorium japonicum Thunb. 13 - 17 g, Polygonum cuspidatum 13 - 17 g, Cornus officinalis 10 - 12 g, Schisandra chinensis 5 - 7 g, Sedum sarmentosum Bunge 27 - 33 g, Atractylodes macrocephala Koidz. 27 - 33 g, Alisma orientale (Sam.) Juz. 10 - 14 g.

[0008] Preferably, calculated by weight, the formula of the traditional Chinese medicine composition is:

[0009] Salvia miltiorrhiza 12 g, Prunus persica 9 g, Rubia cordifolia 9 g, Eupatorium japonicum Thunb. 15 g, Polygonum cuspidatum 15 g, Cornus officinalis 12 g, Schisandra chinensis 6 g, Sedum sarmentosum Bunge 30 g, Atractylodes macrocephala Koidz. 30 g, Alisma orientale (Sam.) Juz. 12 g.

[0010] Preferably, calculated by weight, the formula of the traditional Chinese medicine composition is:

[0011] Salvia miltiorrhiza 10 g, Prunus persica 10 g, Rubia cordifolia 10 g, Eupatorium japonicum Thunb. 13 g, Polygonum cuspidatum 13 g, Cornus officinalis 10 g, Schisandra chinensis 5 g, Sedum sarmentosum Bunge 27 g, Atractylodes macrocephala Koidz. 27 g, Alisma orientale (Sam.) Juz. 10 g.

[0012] Preferably, by weight, the formula of the traditional Chinese medicine composition is as follows:

[0013] 14 grams of Salvia miltiorrhiza, 12 grams of Prunus persica, 12 grams of Rubia cordifolia, 17 grams of Eupatorium japonicum, 17 grams of Polygonum cuspidatum, 12 grams of Macrocarpium officinale, 7 grams of Schisandra chinensis, 33 grams of Sedum sarmentosum, 33 grams of Atractylodes macrocephala, and 14 grams of Alisma orientale.

[0014] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of Bupleurum chinense, Curcuma aromatica, and Cyperus rotundus.

[0015] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of Paeonia lactiflora, Paeonia veitchii, and Cynanchum paniculatum.

[0016] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of Fructus Aurantii, Fructus Akebiae, and Sappanwood.

[0017] Preferably, by weight, the formula of the traditional Chinese medicine composition further includes one or any combination of Endothelium Corneum Gigeriae Galli, Medicated Leaven, and Fructus Hordei Germinatus.

[0018] In the second aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating liver diseases is provided. According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, 400 ml of clear water is added, and after boiling over high heat, it is continuously decocted for 30 minutes, and the medicinal liquid is filtered and extracted;

[0019] 400 ml of clear water is added to the medicinal residues, and after boiling over high heat, it is continuously decocted for 30 minutes, and the medicinal liquid is filtered and extracted;

[0020] The medicinal liquids extracted twice are combined.

[0021] In the third aspect of the present invention, an application of a traditional Chinese medicine composition for treating liver diseases is provided. The traditional Chinese medicine composition for treating liver diseases is used for treating fatty liver hepatitis of blood stasis blocking collaterals, toxin accumulation with damp stagnation, spleen transportation disorder, and liver yin deficiency type, and has the effects of promoting blood circulation to remove blood stasis and detoxify, promoting spleen function to promote diuresis, and nourishing the liver and softening the liver.

[0022] The present invention has the following beneficial effects compared with the prior art:

[0023] The traditional Chinese medicine composition is used for treating fatty liver hepatitis of blood stasis blocking collaterals, toxin accumulation with damp stagnation, spleen transportation disorder, and liver yin deficiency type, and has the effects of promoting blood circulation to remove blood stasis and detoxify, promoting spleen function to promote diuresis, and nourishing the liver and softening the liver.

[0024] Salvia miltiorrhiza promotes blood circulation and nourishes blood, removes blood stasis and dredges collaterals; Prunus persica removes blood stasis and dredges collaterals, dissipates stasis and softens the liver. The two herbs together serve as the monarch herbs. Rubia cordifolia cools blood and stops bleeding, removes blood stasis and soothes the hypochondrium; Eupatorium japonicum promotes blood circulation and removes blood stasis, promotes diuresis and reduces swelling; Polygonum cuspidatum promotes diuresis and clears heat, detoxifies and disperses stasis; Sedum sarmentosum promotes diuresis and reduces jaundice, clears heat and detoxifies.

[0025] The combination of the four herbs aids the monarch herb in achieving the effects of promoting diuresis to eliminate turbidity, removing stasis and detoxifying, and together they serve as the ministerial herbs. Fructus Corni tonifies the liver and kidney, and Schisandra chinensis generates fluid and tranquilizes the mind. Both herbs have the function of astringing and consolidating, preventing the herbs of the monarch and ministerial categories from being too promoting in action, and also having the effects of tonifying the liver and kidney, nourishing yin and enriching blood, which is beneficial for softening the liver and strengthening the root. Atractylodes macrocephala invigorates the spleen and benefits qi, and Alisma orientale promotes diuresis and percolates dampness, having the effect of regulating the spleen and harmonizing, and also flexibly reflecting the concept of the ancient sage that "when liver disease is detected, it is known that the liver will transmit to the spleen, and the spleen should be strengthened first". Detailed implementation mode

[0026] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0027] The present invention provides a traditional Chinese medicine composition for treating liver diseases. Calculated by weight, the formula of the traditional Chinese medicine composition at least includes:

[0028] Salvia miltiorrhiza 10 - 14 g, Prunus persica 10 - 12 g, Rubia cordifolia 10 - 12 g, Eupatorium japonicum 13 - 17 g, Polygonum cuspidatum 13 - 17 g, Fructus Corni 10 - 12 g, Schisandra chinensis 5 - 7 g, Sedum sarmentosum 27 - 33 g, Atractylodes macrocephala 27 - 33 g, Alisma orientale 10 - 14 g.

[0029] Among them, Salvia miltiorrhiza promotes blood circulation and nourishes blood, removes stasis and dredges collaterals, and Prunus persica removes stasis and dredges collaterals, dissipates nodules and softens the liver. The two herbs together serve as the monarch herbs. Rubia cordifolia cools the blood and stops bleeding, removes stasis and relieves the hypochondrium, and Eupatorium japonicum promotes blood circulation and removes stasis, promotes diuresis and reduces swelling; Polygonum cuspidatum promotes diuresis and clears heat, detoxifies and disperses stasis, and Sedum sarmentosum promotes diuresis and reduces jaundice, clears heat and detoxifies.

[0030] The combination of the four herbs aids the monarch herb in achieving the effects of promoting diuresis to eliminate turbidity, removing stasis and detoxifying, and together they serve as the ministerial herbs. Fructus Corni tonifies the liver and kidney, and Schisandra chinensis generates fluid and tranquilizes the mind. Both herbs have the function of astringing and consolidating, preventing the herbs of the monarch and ministerial categories from being too promoting in action, and also having the effects of tonifying the liver and kidney, nourishing yin and enriching blood, which is beneficial for softening the liver and strengthening the root.

[0031] Atractylodes macrocephala invigorates the spleen and benefits qi, and Alisma orientale promotes diuresis and percolates dampness, having the effect of regulating the spleen and harmonizing, and also flexibly reflecting the concept of the ancient sage that "when liver disease is detected, it is known that the liver will transmit to the spleen, and the spleen should be strengthened first".

[0032] It can effectively treat fatty liver hepatitis of the types of blood stasis blocking collaterals, toxin accumulation with damp stagnation, spleen transportation disorder, and liver yin deficiency, and has the effects of promoting blood circulation and detoxifying, regulating the spleen and promoting diuresis, nourishing yin and softening the liver.

[0033] Example 1:

[0034] The formula of the traditional Chinese medicine composition is Salvia miltiorrhiza 12 g, Prunus persica 9 g, Rubia cordifolia 9 g, Eupatorium japonicum 15 g, Polygonum cuspidatum 15 g, Fructus Corni 12 g, Schisandra chinensis 6 g, Sedum sarmentosum 30 g, Atractylodes macrocephala 30 g, Alisma orientale 12 g.

[0035] Example 2:

[0036] The formula of the traditional Chinese medicine composition is 10 grams of Salvia miltiorrhiza, 10 grams of Prunus persica, 10 grams of Rubia cordifolia, 13 grams of Lycopus lucidus, 13 grams of Polygonum cuspidatum, 10 grams of Cornus officinalis, 5 grams of Schisandra chinensis, 27 grams of Sedum sarmentosum, 27 grams of Atractylodes macrocephala, and 10 grams of Alisma orientale.

[0037] Example 3:

[0038] The formula of the traditional Chinese medicine composition is 14 grams of Salvia miltiorrhiza, 12 grams of Prunus persica, 12 grams of Rubia cordifolia, 17 grams of Lycopus lucidus, 17 grams of Polygonum cuspidatum, 12 grams of Cornus officinalis, 7 grams of Schisandra chinensis, 33 grams of Sedum sarmentosum, 33 grams of Atractylodes macrocephala, and 14 grams of Alisma orientale.

[0039] The preparation method is as follows: According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, and 400 ml of clear water is added. After boiling over high heat, continue to decoct for 30 minutes, and then filter to extract the medicinal liquid;

[0040] Add 400 ml of clear water to the medicinal residues, boil over high heat, and then continue to decoct for 30 minutes, and filter to extract the medicinal liquid;

[0041] Combine the medicinal liquids extracted twice.

[0042] Such as chronic non-alcoholic or alcoholic fatty liver, chronic hepatitis B or hepatitis B virus carriers, immune liver disease, or abnormal liver function of unknown cause, etc. The pathological basis of such patients is mainly the long-term accumulation of turbid toxin in the body, which causes blood stasis and poor circulation, and the stagnation of damp turbidity, thus resulting in abnormal liver dredging function. Prolonged illness leads to the invasion of collaterals. If the stasis and turbidity in the patient's body cannot be resolved, not only are the clinical symptoms difficult to improve, but also laboratory indicators such as liver function transaminases are difficult to return to normal, or often fluctuate repeatedly between the critical values. Therefore, in the treatment, promoting blood circulation to remove stasis and resolving turbidity and dampness are the main methods, removing the stasis, turbidity and damp toxin accumulated in the body, and then cooperating with astringing yin and softening the liver, strengthening the spleen and replenishing qi to consolidate the root.

[0043] Based on the pathogenesis of stasis and turbidity accumulation and liver yin deficiency in patients with chronic liver disease, this traditional Chinese medicine composition is formulated on the basis of promoting blood circulation to remove stasis and nourishing yin and softening the liver, and the medicine is in line with the syndrome. In clinical application, based on this formula, it is flexibly modified according to the syndrome to treat chronic liver disease, and indeed can achieve relatively satisfactory curative effects.

[0044] The following provides specific clinical data:

[0045] Yang XX, male, 49 years old. Chief complaint: Fatigue for more than 1 month. Symptoms include fatigue, poor appetite, heaviness of the limbs that is relieved after sweating during exercise, blurred vision, restless sleep, unsmooth stools, and soreness in the waist. He has a history of multiple liver nodules, hepatitis B virus infection, and thyroid nodules. Diagnosis: Lethargy, overweight body shape, normal heart and lungs, normal body temperature, dark red tongue, thin and greasy tongue coating, and stringy and thready pulse. Syndrome differentiation: Stasis and turbidity internal binding, qi and yin deficiency.

[0046] Taking Example 1 as the preferred one, the traditional Chinese medicine composition for treating liver diseases is used for treatment with additional ingredients.

[0047] Prescription: The formula of the traditional Chinese medicine composition is 12 grams of Salvia miltiorrhiza, 9 grams of Prunus persica, 9 grams of Rubia cordifolia, 15 grams of Lycopus lucidus, 15 grams of Polygonum cuspidatum, 12 grams of Cornus officinalis, 6 grams of Schisandra chinensis, 30 grams of Sedum sarmentosum, 30 grams of Atractylodes macrocephala, and 12 grams of Alisma orientale.

[0048] After treatment with 14 doses according to the above formula (taken once in the morning and once in the afternoon), the follow-up visit shows that the patient reports obvious improvement in fatigue, improved appetite, and soft stools.

[0049] Since the course of disease of such patients is long and the long-term consumption is relatively serious, the medication should not be too drastic. Even if the patient has obvious stasis symptoms or is accompanied by nodules, cysts, etc., caution should be exercised when using blood-activating and stasis-removing drugs such as Rheum palmatum, Hirudo, Scolopendra subspinipes, and Buthus martensii. Because many patients have a mixed condition of deficiency and stasis, simply attacking pathogens may consume healthy qi and accelerate the progression of the disease. If it is indeed necessary to attack pathogens, the patient's condition should be closely observed to adjust the medication and dosage at any time. Due to the differences in the physical conditions and diseases of patients, additional ingredients should be flexibly added during clinical practice.

[0050] If the liver qi stagnation is obvious, Bupleurum chinense, Curcuma aromatica, and Cyperus rotundus can be appropriately added.

[0051] If there is chest and hypochondrium pain, Paeonia lactiflora, Paeonia veitchii, and Cynanchum paniculatum can be added;

[0052] If there is abdominal distension and fullness, Fructus Aurantii, Akebia trifoliata, and Caesalpinia sappan can be added;

[0053] If there is anorexia and less food intake, Endothelium Corneum Gigeriae Galli, Medicago sativa, and Hordeum vulgare can be added;

[0054] If there is anxiety and insomnia, Fructus Gardeniae, Semen Platycladi, and Semen Ziziphi Spinosae can be added;

[0055] If the patient usually has a preference for alcohol, Pueraria lobata, Hovenia dulcis, and Coix lacryma-jobi can be added;

[0056] If the blood lipid is on the high side, Gynostemma pentaphyllum, Wenyujin concinna, and Folium Nelumbinis can be added;

[0057] If the yin deficiency is more obvious, Carapax et Plastrum Testudinis, Rehmannia glutinosa, and Colla Corii Asini can be added;

[0058] If the kidney yang deficiency is manifested, Epimedium brevicornu, Eucommia ulmoides, and Alpinia oxyphylla can be appropriately added;

[0059] For patients with spleen and stomach weakness, Codonopsis pilosula, Dioscorea opposita, and Poria cocos can be added.

[0060] For patients with liver insufficiency with retention of damp-heat toxin, Sedum sarmentosum can not only detoxify but also reduce enzyme levels. Other herbs such as Hypericum japonicum, Polygonum cuspidatum, Bidens pilosa, Phyllanthus niruri, and Elsholtzia fruticosa can be used as appropriate.

[0061] The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements within the essence and protection scope of the present application, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating liver diseases, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition at least includes: 10-14 grams of Salvia miltiorrhiza, 10-12 grams of Prunus persica, 10-12 grams of Rubia cordifolia, 13-17 grams of Eupatorium japonicum, 13-17 grams of Polygonum cuspidatum, 10-12 grams of Cornus officinalis, 5-7 grams of Schisandra chinensis, 27-33 grams of Sedum sarmentosum, 27-33 grams of Atractylodes macrocephala, 10-14 grams of Alisma orientale.

2. The traditional Chinese medicine composition for treating liver diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 12 grams of Salvia miltiorrhiza, 9 grams of Prunus persica, 9 grams of Rubia cordifolia, 15 grams of Eupatorium japonicum, 15 grams of Polygonum cuspidatum, 12 grams of Cornus officinalis, 6 grams of Schisandra chinensis, 30 grams of Sedum sarmentosum, 30 grams of Atractylodes macrocephala, 12 grams of Alisma orientale.

3. The traditional Chinese medicine composition for treating liver diseases according to claim 1, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 10 grams of Salvia miltiorrhiza, 10 grams of Prunus persica, 10 grams of Rubia cordifolia, 13 grams of Eupatorium japonicum, 13 grams of Polygonum cuspidatum, 10 grams of Cornus officinalis, 5 grams of Schisandra chinensis, 27 grams of Sedum sarmentosum, 27 grams of Atractylodes macrocephala, 10 grams of Alisma orientale.

4. The traditional Chinese medicine composition for treating liver diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition is: 14 grams of Salvia miltiorrhiza, 12 grams of Prunus persica, 12 grams of Rubia cordifolia, 17 grams of Eupatorium japonicum, 17 grams of Polygonum cuspidatum, 12 grams of Cornus officinalis, 7 grams of Schisandra chinensis, 33 grams of Sedum sarmentosum, 33 grams of Atractylodes macrocephala, 14 grams of Alisma orientale.

5. The traditional Chinese medicine composition for treating liver diseases according to claim 1, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any several of Bupleurum chinense, Curcuma aromatica, and Cyperus rotundus.

6. The traditional Chinese medicine composition for treating liver diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any several of Paeonia lactiflora, Paeonia veitchii, and Cynanchum paniculatum.

7. The traditional Chinese medicine composition for treating liver diseases according to claim 1, wherein, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any several of Aurantii Fructus Immaturus, Akebia trifoliata, and Sappanwood.

8. The traditional Chinese medicine composition for treating liver diseases according to claim 1, characterized in that, Calculated by weight parts, the formula of the traditional Chinese medicine composition further includes one or any several of Endothelium Corneum Gigeriae Galli, Medicated Leaven, and Fructus Hordei Germinatus.

9. A method for preparing a traditional Chinese medicine composition for treating liver diseases as described in any one of claims 1-8, characterized in that, According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, and 400 ml of clear water is added. After boiling with strong fire, continue to decoct for 30 minutes, and filter to extract the medicinal liquid; Add 400 ml of clear water to the medicinal residues, boil with strong fire, and continue to decoct for 30 minutes, and filter to extract the medicinal liquid; Combine the medicinal liquids extracted twice.

10. Use of a traditional Chinese medicine composition for treating liver diseases according to any one of claims 1-8, characterized in that, The traditional Chinese medicine composition for treating liver diseases is used to treat fatty liver hepatitis of the types of blood stasis blocking collaterals, toxin accumulation with damp stagnation, spleen transportation disorder, and liver yin deficiency, and has the effects of promoting blood circulation and detoxification, promoting the function of the spleen and promoting diuresis, and nourishing the liver and softening the liver.