Blood sample storage device for LC-MS detection

Abstract

The invention relates to the technical field of blood sample storage, and provides a blood sample storage device for LC-MS detection, comprising a storage box for storing test tubes; the test tube storage device further comprises a connecting ring which is arranged in the storage box in a swinging mode, and the test tubes penetrate through the connecting ring, move in the axial direction of the connecting ring and swing along with the connecting ring. According to the technical scheme, the problem that the mixing effect of blood and an anticoagulant cannot be improved in the prior art is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of blood sample storage, and in particular to a blood sample storage device for LC-MS detection. Background Art

[0002] LC-MS is an efficient and sensitive analytical method in blood detection, which can be used to analyze disease-related metabolites, determine hormone levels, and detect abnormalities such as amino acids and organic acids. Before detection, blood samples need to be processed. When collecting and transporting blood samples, a storage device is required to protect the samples.

[0003] In the existing blood sample storage device, generally, a temperature control component is used to regulate the temperature inside the storage box to maintain a suitable storage temperature, and a rotating device is also used to rotate the test tube containing the blood sample to maintain the good state of the blood sample. However, by rotating the test tube in a circular motion, the periodic action is too stable, and the mixing effect of the blood in the test tube is weak, which cannot ensure better mixing of the blood and the anticoagulant in the test tube, and cannot ensure the blood storage quality. However, excessive shaking or jitter may generate bubbles, affecting subsequent centrifugation or interfering with chromatographic separation detection.

[0004] In the prior art, the problem that the mixing effect of blood and anticoagulant cannot be improved needs to be solved. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a blood sample storage device for LC-MS detection in view of the above-mentioned technical deficiencies, which solves the problem in the prior art that the mixing effect of blood and anticoagulant cannot be improved.

[0006] The technical solution adopted by the present invention is: to provide a blood sample storage device for LC-MS detection, including a storage box for storing test tubes; and further including:

[0007] A connecting ring is swingably arranged in the storage box, the test tube passes through the connecting ring, the test tube is movably arranged along the axial direction of the connecting ring, and the test tube swings along with the connecting ring.

[0008] To further optimize the technical solution, it further includes:

[0009] A positioning ring is located below the connecting ring and is movably arranged relative to the connecting ring and swings along with the connecting ring. The test tube is slidably sleeved in the positioning ring, and the test tube moves along with the positioning ring.

[0010] To further optimize the technical solution, the lower end of the positioning ring has a guide rod, the guide rod is beside the test tube, and it further includes:

[0011] A compression spring acts on the connecting ring at one end and on the positioning ring at the other end, and is used to provide a thrust for the positioning ring to move away from the connecting ring.

[0012] A guide plate is arranged in the storage box and below the positioning ring. The upper part of the guide plate has a guiding part, and the guiding part includes several convex structures. The lower end of the guide rod abuts against the guiding part. After the connecting ring swings, the guide rod moves along the guiding part, which is used to drive the positioning ring to move relative to the connecting ring, and the test tube moves along with the positioning ring.

[0013] To further optimize this technical solution, there are several connecting rings, and the several connecting rings are distributed in several rows in an array. A positioning ring is arranged below each connecting ring, and at least one guide plate is arranged below each positioning ring.

[0014] To further optimize this technical solution, it further includes:

[0015] A push plate is arranged in the lower part of the storage box in a lifting manner. After the push plate rises, it abuts against the lower end of the test tube, and is used to push the test tube to move relative to the positioning ring.

[0016] To further optimize this technical solution, it further includes:

[0017] A linear drive unit is arranged in the lower part of the storage box and is used to drive the push plate to lift.

[0018] To further optimize this technical solution, it further includes:

[0019] A transmission drive unit is arranged on the storage box and is used to drive several connecting rings to rotate synchronously.

[0020] To further optimize this technical solution, it further includes:

[0021] A heat preservation component is arranged in the storage box and is used to regulate the temperature in the storage box.

[0022] The beneficial effects of the present invention are as follows:

[0023] 1. The connecting ring drives the test tube to swing, so that the blood and anticoagulant in the test tube are mixed more fully and evenly. Compared with circular rotation, the swinging mixing method is conducive to the full flow of blood and the mixing is more uniform.

[0024] 2. If the test tube moves along the axial direction of the connecting ring, the swing radius of the test tube will change accordingly, and the flow intensity of the blood in the test tube can be adjusted. When the swing radius is long, the swing is large and the mixing effect is strong, which improves the mixing effect of the blood and the anticoagulant. After the swing radius is reduced, the swing gradually decreases, and the blood flow mixing tends to be stable, maintaining the blood flow state, avoiding the formation of bubbles caused by long-term high-intensity swinging, facilitating the aggregation of blood in the test tube, and reducing the liquid hanging on the tube wall. Description of the Drawings

[0025] Figure 1 It is a schematic structural diagram of the present invention;

[0026] Figure 2 It is a schematic right-view structural diagram of the present invention;

[0027] Figure 3 of the present invention Figure 2 It is a schematic diagram of the partial enlarged structure at a in [the figure];

[0028] Figure 4 It is a schematic front-view structural diagram of the present invention;

[0029] Figure 5 It is a schematic diagram of the test tube placement structure of the present invention;

[0030] Figure 6 It is a schematic diagram of the storage box structure of the present invention;

[0031] Figure 7 It is a schematic diagram of the internal sectional structure of the storage box of the present invention;

[0032] Figure 8 It is a schematic diagram of the test tube swing state of the present invention;

[0033] Explanation of the marks in the figure: 1. Storage box; 2. Test tube; 3. Connecting ring; 301. Shaft rod; 4. Positioning ring; 401. Guide rod; 402. Compression spring; 5. Guide plate; 501. Guide part; 6. Pushing plate. Detailed Description of the Invention

[0034] The present invention will be further described in detail below in conjunction with the drawings and the specific embodiments.

[0035] For the sake of simplicity of the drawings, only the parts related to the invention are schematically shown in each figure, and they do not represent the actual structure of the product. In addition, for the sake of simplicity and easy understanding of the drawings, in some figures, components with the same structure or function are only schematically shown for one of them, or only one of them is marked. In this article, "one" not only means "only this one", but also means "more than one" situation, and "several" includes "two" and "more than two".

[0036] In this text, it should be noted that unless otherwise clearly specified and defined, the terms "install", "connect", and "join" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] In addition, in the description of the present application, the terms "first", "second", etc. are only used for distinguishing descriptions and cannot be understood as indicating or implying relative importance.

[0038] As Figure 1-8 shown, a blood sample storage device for LC-MS detection includes a storage box 1 for storing test tubes 2; it further includes: a connecting ring 3 swingably arranged in the storage box 1, the test tube 2 passes through the connecting ring 3, the test tube 2 is movably arranged along the axial direction of the connecting ring 3, and the test tube 2 swings following the connecting ring 3. It further includes: a positioning ring 4 located below the connecting ring 3, movably arranged relative to the connecting ring 3, swinging following the connecting ring 3, the test tube 2 is slidably sleeved in the positioning ring 4, and the test tube 2 moves following the positioning ring 4.

[0039] During use, the test tube 2 filled with a blood sample is inserted into the connecting ring 3, and the test tube 2 swings in a vertical plane following the connecting ring 3. Initially, the lower part of the test tube 2 (the blood sample is concentrated in the lower part) is located below the connecting ring 3 and is in the longest extended state. At this time, the connecting tube drives a larger swing amplitude of the lower part of the test tube 2, and the shaking effect is more obvious, strengthening the blood mixing effect in the test tube 2. Then, the test tube 2 moves relatively upward, the length of the lower part of the test tube 2 extending out decreases, and the swing amplitude of the lower part of the test tube 2 also decreases accordingly, and the shaking and mixing effect weakens.

[0040] The test tube 2 can be inserted into the connecting ring 3, and the diameter direction of the connecting ring 3 is the swing axis position. It can also be clamped and sleeved outside the test tube 2 through the positioning ring 4. The test tube 2 passes through the connecting ring 3 and there can be a gap. The positioning ring 4 tightly sleeves and fixes the test tube 2. At the same time, under the action of a relatively large force, the test tube 2 can also axially move relative to the positioning ring 4, so as to move and adjust the swing radius relative to the connecting ring 3. The middle part of the connecting ring 3 is a ring structure, with connecting ears on both sides. A shaft rod 301 can be arranged on the lower side of the connecting ears. A sliding connection can be realized between the positioning ring 4 and the connecting ring 3 through the shaft rod 301. Then the positioning ring 4 moves in the axial direction relative to the connecting ring 3 axis, and the positioning ring 4 drives the test tube 2 to reciprocally move relative to the connecting ring 3, which can realize the up and down shaking of the test tube 2. The swing plus the up and down shaking is beneficial to further strengthening the flow and mixing of the blood inside the test tube 2.

[0041] Furthermore, the lower end of the positioning ring 4 has a guide rod 401. The guide rod 401 is located beside the test tube 2 and further includes: a compression spring 402, with one end acting on the connecting ring 3 and the other end acting on the positioning ring 4, for providing a thrust force for the positioning ring 4 to move away from the connecting ring 3; a guide plate 5, arranged in the storage box 1 and located below the positioning ring 4. The upper part of the guide plate 5 has a guiding portion 501, and the guiding portion 501 includes several protruding structures. The lower end of the guide rod 401 abuts on the guiding portion 501. When the connecting ring 3 swings, the guide rod 401 moves along the guiding portion 501, for driving the positioning ring 4 to move relative to the connecting ring 3, and the test tube 2 follows the positioning ring 4 to move.

[0042] During use, the movement of the positioning ring 4 relative to the connecting ring 3 can be achieved through the compression spring 402 and the guiding portion 501. The guiding portion 501 can be arc-shaped to facilitate matching the swinging trajectory of the test tube 2. In one swinging direction, the rising section and the falling section can be realized on the guiding portion 501 through the protruding structures. The lower end of the guide rod 401 is in sliding fit with the guiding portion 501, and thus the positioning ring 4 can be pushed up in the rising section. The positioning ring 4 approaches the connecting ring 3, and the positioning ring 4 drives the test tube 2 upward. In the falling section, the positioning ring 4 descends away from the connecting ring 3, and the positioning ring 4 drives the test tube 2 downward. Thereby, during the swinging process of the test tube 2, it reciprocates in the radial direction, so that the blood inside is better oscillated and mixed.

[0043] The lower part of the guide rod 401 can be in rolling combination with the guiding portion 501 through a roller structure or the like to reduce resistance. The protruding structures on the guiding portion 501 can be gear-shaped, broken-line-shaped, semi-circular, etc.

[0044] Furthermore, there are several connecting rings 3, and the several connecting rings 3 are distributed in several rows in an array. A positioning ring 4 is arranged below each connecting ring 3, and at least one guide plate 5 is arranged below each positioning ring 4.

[0045] During use, generally multiple blood samples are stored simultaneously. Therefore, there are multiple connecting rings 3 and positioning rings 4, etc., and they are distributed in an array in the storage box 1, divided into multiple rows. Each row has multiple connecting rings 3 arranged side by side, and the rotation axis of the connecting tube is its diameter direction. When multiple connecting rings 3 and positioning rings 4 are arranged, due to the difference in blood sampling time, several test tubes 2 are gradually placed into different positioning rings 4 in the storage box 1. When each test tube 2 is initially placed, it is in a strong mixing state with a large swinging radius, while the swinging radius of the previously placed test tube 2 has gradually decreased. Each test tube 2 can have independent adjustment conditions, and it will not cause excessive shaking and mixing of the previously placed test tube 2 to produce bubbles.

[0046] Further, it further includes: a push plate 6, which is arranged at the lower part inside the storage box 1 in a lifting manner. After the push plate 6 rises, it abuts against the lower end of the test tube 2 and is used to push the test tube 2 to move relative to the positioning ring 4. It also includes a linear drive unit, which is arranged at the lower part inside the storage box 1 and is used to drive the push plate 6 to lift.

[0047] During use, the movement of the test tube 2 relative to the connecting ring 3 or the positioning ring 4 can be adjusted by the manual operation of medical staff, and can also be automatically adjusted by the push plate 6. Initially, the lower part of the test tube 2 extends out of the positioning ring 4 more, and the swing radius is large. When the test tube 2 moves upward, the extension gradually decreases. At this time, it is only necessary to rely on the upward movement of the push plate 6 to push the test tube 2 upward, reducing manual operation and enabling all test tubes 2 to move synchronously. That is, when a new test tube 2 is just placed, when manually inserted, the positioning ring 4 extends downward more. After shaking and mixing for a period of time, the push plate 6 can gradually push the newly inserted test tube 2 upward until all test tubes 2 are synchronized. When the push plate 6 pushes the test tube 2, a thrust can be applied when the test tube 2 is in a vertical state, which is convenient for realizing the movement of the test tube 2. When the test tube 2 is tilted, it is not easy for the push plate 6 to push the test tube 2 to move relative to the positioning ring 4. The compression spring 402 can provide different forces for the position of the positioning ring 4, or the compression spring 402 can be compressed to the limit first, and then the push plate 6 can push the test tube 2 to displace relative to the positioning ring 4.

[0048] After the push plate 6 pushes the test tube 2 to move, it can descend to maintain a low position, avoiding affecting the swing of the test tube 2 and facilitating the insertion of a new test tube 2 at the same time. During the swing of the test tube 2, the push plate 6 can also rise, so that the bottom of the test tube 2 impacts the push plate 6 in an inclined state, thereby improving the blood oscillation and flow effect in the test tube 2.

[0049] The upward movement of the push plate 6 can rely on a linear drive unit such as a lead screw structure or a linear drive motor for reciprocating lifting drive to achieve automated operation. The linear drive unit is an existing device, which can be realized by those skilled in the art and is not shown in the drawings.

[0050] Similarly, a pressing plate can also be arranged at the upper part inside the storage box 1 in a lifting manner. The pressing plate presses down the test tube 2, so that the test tube 2 extends downward more again, and reciprocally adjusts to change the swing strength, strengthening the mixing and flow to avoid coagulation.

[0051] Further, it further includes: a transmission drive unit, which is arranged on the storage box 1 and is used to drive a plurality of connecting rings 3 to rotate synchronously. It also includes: a heat preservation component, which is arranged inside the storage box 1 and is used to regulate the temperature inside the storage box 1.

[0052] During use, the rotation of the connecting ring 3 can be driven by a transmission drive unit such as a motor. Multiple rows of connecting rings 3 can achieve synchronous and co-directional rotation through a transmission structure such as gears or belts. The transmission drive unit can be located beside the storage box 1 and is realized through a motor and a gear transmission structure, which is a conventional technical means and is not shown in the drawings.

[0053] A conventional heat preservation component or the like can also be additionally provided in the storage box 1 to set and control the internal temperature. A cover plate that can be opened and closed is provided on the upper side of the storage box 1.

[0054] It can be understood that the present invention is described through some embodiments. Those skilled in the art know that without departing from the spirit and scope of the present invention, various changes or equivalent replacements can be made to these features and embodiments. In addition, under the teaching of the present invention, these features and embodiments can be modified to adapt to specific situations and materials without departing from the spirit and scope of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application belong to the scope protected by the present invention.

Claims

1. A blood sample storage device for LC-MS detection, comprising a storage box (1) for storing test tubes (2); characterized in that, Further included are: A connecting ring (3), which is swingably arranged inside the storage box (1). The test tube (2) passes through the connecting ring (3), and the test tube (2) is movably arranged along the axial direction of the connecting ring (3), and the test tube (2) swings following the connecting ring (3).

2. The blood sample storage device for LC-MS detection according to claim 1, wherein, Further included are: A positioning ring (4), which is located below the connecting ring (3) and is movably arranged relative to the connecting ring (3) and swings following the connecting ring (3). The test tube (2) is slidably sleeved inside the positioning ring (4), and the test tube (2) moves following the positioning ring (4).

3. The blood sample storage device for LC-MS detection according to claim 2, wherein The lower end of the positioning ring (4) is provided with a guide rod (401), and the guide rod (401) is located beside the test tube (2). Further included are: A compression spring (402), one end of which acts on the connecting ring (3) and the other end acts on the positioning ring (4), and is used to provide a thrust for the positioning ring (4) to move away from the connecting ring (3); A guide plate (5), which is arranged inside the storage box (1) and is located below the positioning ring (4). The upper part of the guide plate (5) is provided with a guiding part (501), and the guiding part (501) includes several convex structures. The lower end of the guide rod (401) abuts against the guiding part (501). After the connecting ring (3) swings, the guide rod (401) moves along the guiding part (501) and is used to drive the positioning ring (4) to move relative to the connecting ring (3), and the test tube (2) moves following the positioning ring (4).

4. The blood sample storage device for LC-MS detection according to claim 3, characterized in that, There are several connecting rings (3), and several connecting rings (3) are distributed in several rows in an array. One positioning ring (4) is arranged below each connecting ring (3), and at least one guide plate (5) is arranged below each positioning ring (4).

5. A blood sample storage device for LC-MS detection according to any one of claims 2-4, characterized in that, Further included are: A push plate (6), which is arranged in the lower part inside the storage box (1) and can be lifted and lowered. After the push plate (6) rises, it abuts against the lower end of the test tube (2) and is used to push the test tube (2) to move relative to the positioning ring (4).

6. The blood sample storage device for LC-MS detection according to claim 5, wherein, Further included are: A linear driving unit, which is arranged in the lower part inside the storage box (1) and is used to drive the push plate (6) to lift and lower.

7. The blood sample storage device for LC-MS detection according to claim 4, characterized in that, Further included are: A transmission driving unit, which is arranged on the storage box (1) and is used to drive several connecting rings (3) to rotate synchronously.

8. The blood sample storage device for LC-MS detection according to claim 1, characterized in that, Further included are: A heat preservation component, which is arranged inside the storage box (1) and is used to regulate the temperature inside the storage box (1).

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