Waterproof closed drying box

Abstract

The invention relates to the technical field of freeze-drying equipment, in particular to a waterproof closed drying box which comprises a frame, a waterproof box cover arranged on the upper portion of the frame, a film pressing edge strip arranged on the lower portion of the frame, a flexible film connected between the frame and the film pressing edge strip in a pressing mode and a screwing cover arranged on the upper portion of the waterproof box cover, and the screwing cover is provided with a hydrophobic breathable film. The detachable assembly design is adopted for the screwing cover, different hydrophobic breathable films can be selectively installed so as to adapt to different freeze-drying processes, and the beneficial effect of reducing the material cost can be achieved; the hydrophobic breathable film adopted by the screwing cover can be sterilized together with the film pressing edge strip, the waterproof box cover, the frame or the freeze-drying base plate by adopting different sterilization processes, so that the sterilization cost can be reduced. And by arranging the flexible film, after freeze-drying is completed, stripping operation of the materials is facilitated, and then the production efficiency can be improved. And meanwhile, impurities of the freeze-dried product caused by scraping are reduced, so that the purity of the freeze-dried product is higher.

Description

Technical Field

[0001] The present invention relates to the technical field of freeze-drying equipment, specifically a waterproof and airtight drying box. Background Art

[0002] Since the freeze-drying technology has great advantages in preserving biological activity and food nutrients, more and more foods and drugs are prepared into preparations by the freeze-drying technology. During the freeze-drying process, raw materials need to be placed in a freeze-drying device to remove moisture from the raw materials. Currently, the containers used to hold raw materials are mostly drying trays or drying boxes. There are the following problems in using drying trays or drying boxes for freeze-drying of materials:

[0003] 1. Since most of the materials are liquids, and most of the drying boxes or drying trays are wide-mouthed boxes. When the drying tray or drying box is pushed into the freeze-drying device, the liquid in the drying box will agitate, and then the liquid may splash out. The splashing of the liquid will lead to inaccurate quantification. At the same time, for special materials, it may also cause equipment contamination and cross-contamination of materials, reducing the product qualification rate.

[0004] 2. After the materials are dried in a drying oven or a freeze-dryer and taken out of the oven for the next operation or transferred to other spaces, the products will come into contact with the outside environmental air and absorb moisture in the air, resulting in moisture absorption and making the products unstable. At the same time, for products with high sterilization requirements, it may also cause bacterial contamination of the products, so the requirements for a sterile production environment are relatively high.

[0005] 3. During the freeze-drying process, the materials may adhere to the drying box. Therefore, after the freeze-drying is completed, it is difficult to unload the materials. In response to this situation, a scraper is mostly used for unloading, which is likely to generate metal particles or plastic particles, which is not conducive to the purity of the products and even makes the products unusable.

[0006] 4. The material drying box is not only a device for holding materials, but also a device for transporting materials. Different products may require different sterilization requirements and different freeze-drying processes. However, the functions and costs of existing drying boxes are fixed. For products with high requirements, the drying boxes may not meet the requirements, and for products with low requirements, it may cause cost waste. Therefore, it is not conducive to cost control. For example, US Patent No. 6517526B1 discloses an improved container for collecting, lyophilizing, storing, reconstituting and administering biological solutions, especially blood products. If the above-mentioned equipment is used for the preparation of freeze-dried products, the production cost will increase greatly. And the above-mentioned container is for small-scale freeze-dried blood and other products with small sizes, which is not suitable for the production of large quantities of materials.

[0007] Therefore, in order to better improve the freeze-drying efficiency, product qualification rate and reduce the freeze-drying cost, it has become an urgent requirement to design a new waterproof and airtight drying tray. Summary of the Invention

[0008] The technical problem to be solved by the present invention is to develop a drying tray for freeze-drying that can improve the freeze-drying efficiency, product qualification rate, and reduce the freeze-drying cost.

[0009] The technical solution for the technical problem to be solved by the present invention is a waterproof and airtight drying box, which includes a frame, a waterproof box cover arranged on the upper part of the frame, a film pressing strip arranged on the lower part of the frame, a flexible film is pressed between the frame and the film pressing strip, and a tightening cover arranged on the upper part of the waterproof box cover, and the tightening cover is provided with a hydrophobic and breathable membrane.

[0010] Preferably, the frame and the film pressing strip are made of stainless steel or plastic.

[0011] Preferably, the waterproof box cover is made of a transparent material.

[0012] Preferably, the flexible film is a PE film, a PP film, oil paper or oil cloth.

[0013] Preferably, the thickness of the flexible film is 0.02 - 0.005 mm.

[0014] Preferably, the frame and the film pressing strip are circular or rectangular in shape.

[0015] Preferably, the hydrophobic and breathable membrane is meltblown cloth, outdoor clothing fabric, PTFE, e-PTFE.

[0016] Preferably, the tightening cover includes a pressing cover and a screwing cover, and the pressing cover fixes the hydrophobic and breathable membrane on the screwing cover.

[0017] A waterproof and airtight drying box, which includes a freeze-drying chassis, a waterproof box cover, a flexible film, and a tightening cover arranged on the upper part of the waterproof box cover. The tightening cover is provided with a hydrophobic and breathable membrane, and the flexible film is arranged on the upper part of the freeze-drying chassis.

[0018] Preferably, the tightening cover includes a pressing cover and a screwing cover, and the pressing cover fixes the hydrophobic and breathable membrane on the screwing cover.

[0019] The beneficial effects of the present invention are as follows:

[0020] 1. The detachable assembly design of the tightening cover allows for the selection of different hydrophobic and breathable membranes to adapt to different freeze-drying processes, achieving the beneficial effect of reducing material costs;

[0021] 2. The hydrophobic and breathable membrane used in the tightening cover can be sterilized using different sterilization processes from the film pressing strip, waterproof box cover, frame, or freeze-drying chassis, thereby reducing sterilization costs.

[0022] 3. By setting the flexible film, it is convenient to unload the materials after freeze-drying is completed, which can improve production efficiency. At the same time, the impurities of the freeze-dried products caused by scraping are reduced, making the freeze-dried products have higher purity.

[0023] 4. By setting the waterproof box cover and the screw-on cap, the airtight protection of the freeze-dried materials can be achieved. When putting them into the freeze-drying equipment before freeze-drying, splashing can be reduced, ensuring the quantitative requirements of the products. At the same time, for the freeze-drying of harmful substances, environmental pollution, harm to personnel and cross-contamination to other freeze-dried products can be reduced. After freeze-drying, during the transfer of the freeze-dried products, external bacteria and impurities can be prevented from entering the drying box to contaminate the freeze-dried products. At the same time, the hydrophobic and breathable membrane set can effectively prevent the freeze-dried products from getting damp, which can further improve the quality of the products. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is the overall schematic diagram of the first embodiment of the present invention.

[0025] Figure 2 It is the exploded view of the first embodiment of the present invention.

[0026] Figure 3 It is the cross-sectional view of the first embodiment of the present invention.

[0027] Figure 4 It is the schematic diagram of the second embodiment of the present invention.

[0028] In the figure: 100, frame; 300, waterproof box cover; 200, film pressing strip; 310, screw-on cap; 400, flexible film; 311, pressing cap; 312, screwing cap; 500, freeze-drying chassis. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0029] To make the technical solutions and beneficial effects of the present invention clearer, the following further elaborates on the embodiments of the present invention in detail.

[0030] Embodiment 1

[0031] The waterproof and airtight drying box includes a frame 100. The upper part of the frame 100 is connected to the waterproof box cover 300, and the lower part of the frame 100 is connected to the film pressing strip 200. The upper part of the waterproof box cover 300 is provided with a screw-on cap 310. A flexible film 400 is press-connected between the lower part of the frame 100 and the film pressing strip 200. A hydrophobic and breathable membrane is provided in the middle of the screw-on cap 310. The frame 100, the film pressing strip 200, the waterproof box cover 300 and the flexible film 400 form a hydrophobic and breathable drying container. When preparing freeze-dried products, the materials are loaded into the drying box and then put into the freeze-drying equipment.

[0032] In this embodiment, the overall shape of the frame 100 is rectangular, and the overall shapes of the film pressing strip 200, the waterproof box cover 300, and the flexible film 400 are the same as that of the frame 100. The frame has a certain height for containing materials. The film pressing strip 200 is a frame structure, matching the shape of the frame 100, which is a rectangular frame. For example, in an actual product, the size of a drying box of one specification is 290mm×210mm. The specific size can be selected according to the size of the freeze-drying equipment. In addition, when the quantitative requirement for the freeze-dried product is relatively high, the thickness of the frame can be set. For example, when the thickness of the film pressing strip 200 is 5mm, combined with the above size, 304,500 ml of solution can be quantified. At this time, the upper limit of the solution quantification is 304,500 ml. At the same time, the sum of the heights of the waterproof box cover 300 and the frame 100 is greater than the height of the film pressing strip 200 and more than 10 times, to ensure sufficient freeze-drying volatilization space and improve the freeze-drying efficiency. At the same time, after the freeze-drying is completed, all the freeze-dried products are in contact with the flexible film 400, so that the material can be taken more conveniently and efficiently.

[0033] The frame 100 can be made of stainless steel or plastic, and stainless steel is preferably used to achieve better cold conduction effect. The waterproof box cover 300 can also be made of stainless steel and plastic. Transparent plastic material can be used to achieve the effect of observing the internal freeze-drying state. By observing the internal freeze-drying state, the parameters in the freeze-drying process can be adjusted in time to determine the optimal freeze-drying parameters, and these parameters can be applied in the subsequent batch preparation process. The film pressing strip 200 can be made of stainless steel or plastic.

[0034] In this embodiment, the frame 100, the film pressing strip 200, and the waterproof box cover 300 are fixedly connected by means of screw connection. That is, a number of through holes penetrating up and down are provided on the frame 100. Through holes are provided at the corresponding positions of the film pressing strip 200, the waterproof box cover 300, and the flexible film 400. After the frame 100, the film pressing strip 200, the waterproof box cover 300, and the flexible film 400 are overlapped according to the up-and-down position relationship, the four components are fixed together with screws. In order to achieve a better sealing effect, a sealing ring or gasket can be provided between the frame 100 and the film pressing strip 200, and between the frame 100 and the waterproof box cover 300.

[0035] In addition, a buckle is provided between the film-pressing edge strip 200 and the waterproof box cover 300, and the frame 100, the film-pressing edge strip 200 and the waterproof box cover 300 are fixed and the flexible film 400 is pressed by the buckle. Alternatively, a card slot is provided on the inner side of the frame 100, and a protruding elastic buckle is provided on the edge of the film-pressing edge strip 200, which is the same as the connection of the cover plate of the battery placement slot of the toy, and is fixed by snap connection. The frame 100 and the waterproof box cover 300 can also be connected by snap connection. Alternatively, studs are provided around the film-pressing edge strip 200, and through holes are provided at the corresponding positions of the frame 100 and the waterproof box cover 300. After the frame 100, the film-pressing edge strip 200, the waterproof box cover 300 and the flexible film 400 are assembled, butterfly bolts are provided on the upper part for fastening.

[0036] In addition, the overall shape of the frame 100, the film pressing strip 200, the waterproof box cover 300 and the flexible film 400 can also be set to a circle. At this time, in addition to being fixed by screw connection and snap connection, the four can also be connected by integral screw connection. That is, the frame 100 is provided with internal threads or external threads, and the film pressing strip 200 and the waterproof box cover 300 are correspondingly provided with external threads or internal threads. The two are connected and fixed by relative rotation. This method can facilitate the assembly of the drying box. At present, the space of the freeze-drying equipment is mostly rectangular space, so the space utilization rate of the freeze-drying equipment is low.

[0037] The screw-on cover 310 is arranged on the upper part of the waterproof box cover 300. A plurality of screw-on covers 310 may be arranged, and two screw-on covers 310 are arranged in the present embodiment. In order to facilitate assembly and to adapt to the requirements of different freeze-dried materials, the screw-on cover 310 includes three parts, namely, a pressure cover 311, a screw cover 312, and a hydrophobic and breathable mold pressed between the pressure cover 311 and the screw cover 312. The pressure cover 311 presses the hydrophobic and breathable mold in the middle of the screw cover 312, and the screw cover 312 is used to connect with the waterproof box cover 300 by screwing. The hydrophobic breathable membrane can be the common meltblown cloth for preparing protective masks, jacket fabric, PTFE (polytetrafluoroethylene, e-PTFE (expanded polytetrafluoroethylene), etc. Different materials have different breathability effects. If freeze-dried products with high protection effects are required (toxic substances, infectious biological materials, etc.), it is necessary to prevent the leakage of materials to prevent the pollution of the environment and harm to the operators, and a higher level of protection is required. Or if it is an acidic or alkaline organic solvent, a material that is resistant to alkali and acid is required. For ordinary freeze-dried protection, general hydrophobic breathable membrane materials can be used.

[0038] With the above structure of the tightening cap 310, different hydrophobic and breathable membrane materials can be configured for the same drying box. Furthermore, different hydrophobic and breathable membranes can be matched according to the requirements of freeze-dried products. Storing the hydrophobic and breathable membranes as replaceable parts in the warehouse occupies much less space than storing the entire drying box in the warehouse. At the same time, using different hydrophobic and breathable membranes for different freeze-drying requirements can also save costs and achieve better economic effects.

[0039] In addition, adopting a modular assembly structure can save the cost of disinfection and sterilization. When the frame 100, the film pressing strip 200, the waterproof box cover 300, etc. are made of stainless steel, the sterilization requirements can be met through high-temperature sterilization. For the flexible thin film 400 and the hydrophobic and breathable membrane in the tightening cap 310, higher sterilization methods are required for disinfection and sterilization. If the overall structure is to meet the sterilization effect, it must be sterilized according to the sterilization method that meets the highest requirements. Therefore, the present invention can greatly reduce the cost in terms of disinfection and sterilization.

[0040] As Figure 2 shown, when the flexible thin film 400 is relatively thin, after pressing and injecting the solution, the bottom of the flexible thin film 400 presents a shape similar to the inner shape of the film pressing strip 200, that is, it becomes a container similar to a rectangle, and the contact area with the bottom of the freeze-drying device is large. When the thickness is relatively large, the shape is similar to an inverted frustum of a cone, and the contact area with the bottom is reduced, thereby reducing the freeze-drying efficiency. Therefore, the thickness of the flexible thin film 400 is selected to be between 0.02 and 0.005 mm, which is similar to the thickness of the fresh-keeping film commonly used in daily life. During actual use tests, when the thickness is greater than 0.02 mm, after freeze-drying, the recovery time of the flexible thin film 400 increases exponentially, which is not conducive to the shedding of the product. Although it can be used, the efficiency is low. At the same time, it is not conducive to the contact between the flexible thin film 400 and the bottom of the freeze-drying device, thereby reducing the freeze-drying efficiency. The thinner the flexible thin film 400 is, the better, but limited by the film production process and cost, a film with a thickness higher than 0.005 mm is selected.

[0041] The flexible thin film 400 can be made of a film made of PE (polyethylene).

[0042] The flexible thin film 400 can also be made of oil paper or oilcloth.

[0043] Preferably, it can also be made of PTFE (Teflon or polytetrafluoroethylene, nylon), etc. PTFE is acid and alkali resistant / corrosion resistant and is the preferred material for drug production. The split assembly method avoids problems such as weak welding and shedding during heating and cooling. Different from the solutions of the patents mentioned in the background technology, the present invention does not use heat-sealing welding, avoiding the defects of Teflon film in heat-sealing welding.

[0044] Embodiment 2

[0045] This embodiment includes a freeze-drying chassis 500, a waterproof box cover 300, a flexible film 400, and a tightening cap 310 provided on the upper part of the waterproof box cover 300. In this embodiment, the waterproof box cover 300 and the freeze-drying chassis 500 are connected to form a sealed space. At the same time, the flexible film 400 is attached to the bottom of the freeze-drying chassis 500. The film can be attached to the bottom of the freeze-drying chassis 500 by electrostatic adsorption, and the air between the flexible film 400 and the freeze-drying chassis 500 is exhausted through a vacuum environment.

[0046] After freeze-drying is completed, the connection between the waterproof box cover 300 and the freeze-drying chassis 500 is released, the freeze-drying chassis 500 is separated from the flexible film 400, and then the freeze-dried product is separated from the flexible film 400.

[0047] In summary, it is only a preferred embodiment of the present invention and is not used to limit the scope of the present invention. Through the above description, relevant staff can make various changes and modifications completely within the scope without departing from the technical idea of this invention. The technical scope of the present invention is not limited to the content in the specification. All equivalent changes and modifications in terms of the shape, structure, features, and spirit described in the claims of the present invention should be included within the scope of the claims of the present invention.

Claims

1. Waterproof and airtight drying box, characterized in that: It includes a frame (100), a waterproof box cover (300) arranged on the upper part of the frame (100), a film pressing strip (200) arranged on the lower part of the frame (100), a flexible film (400) is press-connected between the frame (100) and the film pressing strip (200), and a tightening cover (310) arranged on the upper part of the waterproof box cover (300), and the tightening cover (310) is provided with a hydrophobic breathable film.

2. The waterproof and airtight drying box according to claim 1, characterized in that: The frame (100) and the film pressing strip (200) are made of stainless steel or plastic.

3. The waterproof and airtight drying box according to claim 1, characterized in that: The waterproof box cover (300) is made of a transparent material.

4. The waterproof and airtight drying box according to claim 1, characterized in that: The flexible film (400) is a PE film, a PTFE film, a PP film, oil paper or oilcloth.

5. The waterproof and airtight drying box according to claim 1, characterized in that: The thickness of the flexible film (400) is 0.02 - 0.005 mm.

6. The waterproof and airtight drying box according to claim 1 or 2, characterized in that: The frame (100) and the film pressing strip (200) are circular frame-shaped or rectangular frame-shaped.

7. The waterproof and airtight drying box according to claim 1, characterized in that: The hydrophobic breathable film is melt-blown cloth, outdoor clothing fabric, PTFE, e-PTFE.

8. The waterproof and airtight drying box according to claim 1, characterized in that: The tightening cover (310) includes a pressing cover (311) and a screwing cover (312), and the pressing cover (311) fixes the hydrophobic breathable film on the screwing cover (312).

9. Waterproof and airtight drying box, characterized in that: It includes a freeze-dried chassis (500), a waterproof box cover (300), a flexible film (400) and a tightening cover (310) arranged on the upper part of the waterproof box cover (300), the tightening cover (310) is provided with a hydrophobic breathable film, and the flexible film (400) is arranged on the upper part of the freeze-dried chassis (500).

10. The waterproof and airtight drying box according to claim 9, characterized in that: The tightening cover (310) includes a pressing cover (311) and a screwing cover (312), and the pressing cover (311) fixes the hydrophobic breathable film on the screwing cover (312).

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