Skin cream containing composite emulsion and preparation method thereof

Abstract

The invention discloses a skin cream containing a composite emulsion and a preparation method thereof, the skin cream comprises the following raw materials by weight: 15-25% of active grease, 5-10% of an emulsifier, 5-10% of a humectant, 2-8% of an active component, 1-3% of a polymer thickener, 0.2-5% of a preservative, and the balance of small molecular group magnetized water. The small molecular group water has stronger seepage force and solubility, can better dissolve and disperse other raw materials, promote interaction among the components and improve the efficacy of the skin cream, and meanwhile, the small molecular group water is more easily absorbed by the skin and is beneficial to improving the uptake efficiency of the skin on nutritional ingredients in the skin cream; the emulsion prepared by the invention is in a W / O / W (water / oil / water) type, effective components or active components in the emulsion can be released only through a two-phase interface, and the release speed of the effective components can be delayed, so that the action time of the effective components is prolonged, the effects of controlled release and delayed release are achieved, and the absorption efficiency of the active components is improved.

Description

Technical Field

[0001] The invention relates to the technical field of skin care products, and in particular to a skin care cream containing a composite emulsion and a preparation method thereof. Background Art

[0002] With the improvement of people's living standards and the increasing pursuit of beauty, the skin care market is booming, with various products emerging in an endless stream, which is dazzling. Although the emulsifiers widely used in traditional skin care products play an important role in evenly dispersing oily and aqueous components to form a stable emulsion, they have obvious drawbacks. Their poor permeability makes it difficult for active ingredients to break through the skin barrier, thus greatly reducing the absorption efficiency.

[0003] In terms of penetration and absorption of active ingredients, this is the key link for skin care products to work. The skin has a natural barrier function, which makes it difficult for the active ingredients in many skin care products to penetrate the surface of the skin smoothly and reach the bottom layer of the skin where they really work, resulting in consumers being unable to obtain the expected moisturizing, anti-oxidation and other effects after use.

[0004] Dosage form stability is also a major challenge in the development of skin care products. Unstable dosage forms may cause stratification, precipitation, deterioration and other problems during storage, which not only affects the appearance and feel of the product, but may also reduce the activity of its active ingredients and even produce harmful substances, posing a threat to consumers' skin health. Therefore, developing a formulation that can effectively improve the penetration and absorption efficiency of active ingredients in skin care products while ensuring dosage form stability has become a key issue that the skin care industry needs to solve. Summary of the invention

[0005] In view of the deficiencies in the prior art, the purpose of the present invention is to provide a skin care cream containing a composite emulsion and a preparation method thereof, so as to solve the technical problems of low penetration and absorption efficiency and poor stability of the current skin care creams.

[0006] In order to achieve the above object, the present invention adopts the following technical scheme:

[0007] The invention provides a skin care cream containing a composite emulsion, which comprises the following raw materials in percentage by weight: 15-25% of active oil, 5-10% of emulsifier, 5-10% of moisturizer, 2-8% of active ingredient, 1-3% of polymer thickener, 0.2-5% of preservative, and the balance is small molecular group magnetized water.

[0008] Preferably, the active oil includes at least one of squalane, caprylic / capric triglyceride and cholesterol.

[0009] The squalane is similar to the oil structure of human skin, has excellent skin affinity, can quickly penetrate into the skin, form a breathable protective film on the skin surface, prevent water loss, play an efficient moisturizing role, and keep the skin soft and smooth.

[0010] The caprylic / capric triglyceride has good moisturizing properties, is light in texture, feels fresh and non-greasy when applied to the skin, can be quickly absorbed by the skin, provides moisture for the skin, and makes the skin soft and delicate.

[0011] The cholesterol helps regulate the sebum secretion of the skin, keeps the sebum secretion in a balanced state, can reduce the oil secretion for oily skin, and can increase the sebum secretion for dry skin, so that the skin maintains an appropriate moisture level.

[0012] Preferably, the emulsifier includes polyglyceryl-3 polyricinoleate, glyceryl oleate citrate, and polyglyceryl-3 diisostearate.

[0013] The mass ratio of polyglyceryl-3 polyricinoleate, glyceryl oleate citrate, and polyglyceryl-3 diisostearate is (3-6):(2-4):(2-4). By using the synergistic effect of the three emulsifiers, a better emulsifying effect can be achieved, and the stability and good skin feel of the skin care cream can be ensured.

[0014] Preferably, the moisturizer includes at least one of glycerin and sorbitol.

[0015] The glycerin has strong hygroscopicity, can absorb moisture from the air and retain the moisture in the stratum corneum of the skin, keeping the skin in a moist state, and is a classic and effective moisturizing ingredient.

[0016] The sorbitol can regulate the texture and taste of skin care products. When used in skin care products, it can make the product have better spreadability and usability, and make the skin feel fresh and comfortable.

[0017] Preferably, the active ingredients include a first component, a second component, and modified sodium hyaluronate. The mass ratio of the first component, the second component, and modified sodium hyaluronate is (1-2):(1-2):(2-4). The first component includes at least one of bisabolol, arnebia root oil, safflower oil, and coenzyme A. The second component includes at least one of asiaticoside and panthenol.

[0018] The first component group is a lipophilic component. Among them, bisabolol has anti-inflammatory and soothing effects, which can reduce skin inflammatory reactions, relieve discomfort symptoms such as skin redness, swelling, and itching, and also has certain antibacterial properties, helping to prevent skin infections, and has good nursing effects on sensitive skin and acne-prone skin; lithospermum oil has the effects of cooling blood, promoting blood circulation, detoxifying and rash-promoting, etc., and mainly plays anti-inflammatory and repair roles in skin care products, can promote skin wound healing, reduce skin inflammation, and has a certain relieving effect on skin problems such as burns and eczema. At the same time, it can also moisturize the skin and improve skin dryness; safflower oil is rich in various nutritional components such as unsaturated fatty acids and vitamins, has the effects of promoting blood circulation to remove blood stasis and nourishing the skin, can promote blood circulation in the skin, enhance skin metabolism, make the skin more healthy and shiny, and can also improve skin elasticity and reduce the formation of wrinkles; coenzyme A participates in the metabolic process of cells, provides energy for skin cells, promotes the renewal and repair of skin cells, enhances skin vitality and resistance, helps to improve the overall state of the skin, and makes the skin more firm and elastic.

[0019] The second component group is a hydrophilic component. Among them, asiaticoside has the effect of promoting the synthesis of skin collagen, can enhance skin toughness and elasticity, reduce the formation of wrinkles and scars, and also has anti-inflammatory and antioxidant effects, can reduce skin inflammation, repair damaged skin, and make the skin smoother and more delicate; panthenol is a precursor of vitamin B5, which is easily absorbed by the skin, has moisturizing and nourishing effects, can penetrate into the skin cutin layer, increase skin moisture content, make the skin soft and smooth, and also has the functions of promoting skin wound healing and cell regeneration, and has a good effect on the repair of damaged skin, can improve the skin barrier function and enhance skin resistance.

[0020] The modified sodium hyaluronate is modified to make the originally hydrophilic sodium hyaluronate have lipophilic characteristics. When ferulic acid is connected to the molecular chains of sodium hyaluronate and sodium alginate through a cross-linking reaction, the hydrophobic benzene ring part endows the modified sodium hyaluronate with certain lipophilicity, making the modified sodium hyaluronate have better compatibility with oil substances to a certain extent, helping it to be evenly dispersed in the skin care product system containing oil components, and improving the stability and use effect of the product.

[0021] Preferably, the preparation method of the modified sodium hyaluronate includes the following steps:

[0022] Sodium alginate was added to deionized water, stirred and dissolved to obtain a sodium alginate solution; sodium hyaluronate was dissolved in deionized water, and then the sodium alginate solution was mixed with the sodium hyaluronate solution to obtain a mixed solution; then ferulic acid was added to the mixed solution, and the crosslinking agent EDC was added, and the pH value was adjusted to 4-6 and the temperature was 25-40 °C. After the reaction, ethanol was added for precipitation, then centrifuged, the precipitate was separated and washed to obtain modified sodium hyaluronate.

[0023] The average molecular weight of the sodium hyaluronate is 10k - 1000kDa.

[0024] Preferably, the mass ratio of the sodium alginate, sodium hyaluronate, and ferulic acid is (1 - 5):(15 - 20):(3 - 5).

[0025] Preferably, the high molecular weight thickener includes at least one of carbomer, xanthan gum, and cellulose; the preservative includes at least one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol, and symex.

[0026] Preferably, the skin cream further includes 0.5 - 0.8% by weight of essence, and the essence is obtained by refining at least one of lilac flower, jasmine flower, rose flower, vanilla leaf, bay leaf, litsea cubeba leaf, orange peel, lemon peel, juniper branch, sandalwood branch, camphor root, iris root, pepper seed, fennel seed, mint grass, and lavender.

[0027] The present invention also provides a preparation method of a skin cream containing a composite emulsion as described above, including the following steps:

[0028] S1. Add the active oil and emulsifier to a stainless steel oil phase stirring pot, heat to 65 - 75 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0029] S2. Magnetize water using a magnetization device to obtain small molecule cluster magnetized water, then add the small molecule cluster magnetized water, humectant, active ingredient, and high molecular weight thickener to a stainless steel water phase stirring pot, heat to 75 - 85 °C, and stir evenly to obtain a water phase;

[0030] S3. Under stirring, slowly add the oil phase to the water phase, and perform vacuum high-speed homogenizing stirring for 15 - 20 min to promote full emulsification of the oil phase and water phase to form a W / O / W type emulsion;

[0031] S4. Vacuum stir the W / O / W type emulsion. When the temperature drops to 44 - 46 °C, add the preservative and essence, perform vacuum high-speed homogenizing stirring for 5 - 10 min, and then continuously stir and cool down to 34 - 36 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0032] Compared with the prior art, the present invention has the following beneficial effects:

[0033] (1) By using a magnetization device to magnetize water to obtain small-molecule cluster magnetized water, the small-molecule cluster water has stronger penetration and solubility, can better dissolve and disperse other raw materials, promote the interaction between components, and improve the efficacy of the skin cream. At the same time, the small-molecule cluster water is more easily absorbed by the skin, which helps to improve the absorption efficiency of the nutritional components in the skin cream by the skin. The emulsion prepared by the present invention is of the W / O / W (water / oil / water) type, and the active ingredients or effective ingredients in the emulsion can be released only through the two-phase interface, which can delay the release rate of the effective ingredients, thereby prolonging their action time, achieving the effects of controlled release and delayed release, and improving the absorption efficiency of the active ingredients.

[0034] (2) The modified sodium hyaluronate prepared by the present invention solves the problem that in a dry environment (such as an air-conditioned room, winter) or under low humidity conditions, there is insufficient moisture in the environment, and there may be a reverse absorption of the moisture inside the skin, thus reducing the moisturizing effect. First, the sodium alginate solution is mixed with the sodium hyaluronate solution. The carboxyl groups and other groups in the sodium alginate molecule can interact with the hydroxyl groups and other groups in the sodium hyaluronate molecule through hydrogen bonds and other interactions to form a denser and more stable network structure film on the skin surface. This film can not only effectively block external pollutants such as dust and bacteria, but also prevent the loss of skin moisture, play a physical barrier role, enhance the skin's resistance to external stimuli, and at the same time help the skin maintain moisture and make the skin present a moist state. Then, under the action of a cross-linking agent, it undergoes a cross-linking reaction with ferulic acid to form a larger molecular weight and more complex three-dimensional network structure. The moisturizing function of sodium hyaluronate, the film-forming function of sodium alginate, and the antioxidant function of ferulic acid cooperate with each other to form a multi-functional protection system, and their respective functions are synergistically enhanced. This cross-linked structure makes the modified sodium hyaluronate stay on the skin surface for a longer time, is not easily damaged by enzymatic hydrolysis or external factors on the skin surface, can continuously exert moisturizing, antioxidant and other effects, prolongs its effective action time in skin care products, and enables the skin to be better cared for in multiple aspects such as moisturizing, anti-aging, and repair. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 It is a flowchart of the preparation method of the skin cream containing a composite emulsion provided by the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0036] The present invention will be further described in detail below through specific preferred embodiments, but the present invention is not limited to the following embodiments.

[0037] It should be noted that unless otherwise specified, the chemical reagents involved in the present invention are all purchased through commercial channels.

[0038] Example 1

[0039] A method for preparing a skin cream containing a composite emulsion, comprising the following steps:

[0040] (1) Add 15 g of squalane, 3 g of polyglyceryl-3 polyricinoleate, 1.5 g of glyceryl oleate citrate, and 1.5 g of polyglyceryl-3 diisostearate to a stainless-steel oil-phase stirring pot, heat to 70 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0041] (2) Magnetize water using a magnetization device to obtain small-cluster magnetized water. Then add 62 mL of small-cluster magnetized water, 8 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of modified sodium hyaluronate, and 1 g of carbomer to a stainless-steel water-phase stirring pot, heat to 80 °C, and stir evenly to obtain a water phase;

[0042] The preparation method of the modified sodium hyaluronate comprises the following steps:

[0043] Add 1 g of sodium alginate to deionized water, stir and dissolve to obtain a sodium alginate solution; dissolve 4 g of sodium hyaluronate in deionized water, then mix the sodium alginate solution and the sodium hyaluronate solution to obtain a mixed solution; then add 1 g of ferulic acid to the mixed solution, add 0.6 g of EDC as a cross-linking agent, adjust the pH value to 5, at a temperature of 30 °C. After the reaction, add ethanol for precipitation, then centrifuge, separate the precipitate, and wash to obtain modified sodium hyaluronate;

[0044] (3) Under stirring, slowly add the oil phase to the water phase, and perform vacuum high-speed homogenization stirring for 18 min at a speed of 3000 rpm to promote the full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion;

[0045] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of Syringa vulgaris extract. After vacuum high-speed homogenization stirring for 8 min at a speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0046] Example 2

[0047] A method for preparing a skin cream containing a composite emulsion, comprising the following steps:

[0048] (1) Add 20 g of squalane, 4 g of polyglyceryl-3 polyricinoleate, 3 g of glyceryl oleate citrate, and 3 g of polyglyceryl-3 diisostearate to a stainless-steel oil-phase stirring pot, heat to 75 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0049] (2) Magnetize water using a magnetization device to obtain small-molecule cluster magnetized water. Then, add 52.5 mL of small-molecule cluster magnetized water, 10 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of modified sodium hyaluronate, and 1 g of carbomer into a stainless-steel aqueous phase stirring pot, heat to 80 °C, and stir evenly to obtain an aqueous phase;

[0050] The preparation method of the modified sodium hyaluronate includes the following steps:

[0051] Add 1 g of sodium alginate into deionized water, stir and dissolve to obtain a sodium alginate solution; dissolve 4 g of sodium hyaluronate in deionized water, then mix the sodium alginate solution with the sodium hyaluronate solution to obtain a mixed solution; then add 1 g of ferulic acid to the mixed solution, add 0.6 g of EDC as a cross-linking agent, adjust the pH value to 5, and react at a temperature of 30 °C. After the reaction, add ethanol for precipitation, then centrifuge, separate the precipitate, and wash to obtain modified sodium hyaluronate;

[0052] (3) Under stirring conditions, slowly add the oil phase to the aqueous phase, and perform high-speed vacuum homogenization stirring for 18 min at a rotation speed of 3000 rpm to promote the full emulsification of the oil phase and the aqueous phase, forming a stable W / O / W emulsion;

[0053] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of Syringa vulgaris extract. After high-speed vacuum homogenization stirring for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0054] Example 3

[0055] A preparation method of a skin cream containing a composite emulsion includes the following steps:

[0056] (1) Add 25 g of squalane, 4 g of polyglyceryl-3 polyricinoleate, 2 g of glyceryl oleate citrate, and 2 g of polyglyceryl-3 diisostearate into a stainless-steel oil phase stirring pot, heat to 65 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0057] (2) Magnetize water using a magnetization device to obtain small-molecule cluster magnetized water. Then, add 56 mL of small-molecule cluster magnetized water, 5 g of glycerol, 1 g of bisabolol, 1 g of asiaticoside, 2 g of modified sodium hyaluronate, and 2 g of carbomer into a stainless-steel aqueous phase stirring pot, heat to 80 °C, and stir evenly to obtain an aqueous phase;

[0058] The preparation method of the modified sodium hyaluronate includes the following steps:

[0059] Add 0.5 g of sodium alginate to deionized water, stir and dissolve to obtain a sodium alginate solution; dissolve 2 g of sodium hyaluronate in deionized water, then mix the sodium alginate solution and the sodium hyaluronate solution to obtain a mixed solution; then add 0.5 g of ferulic acid to the mixed solution, add 0.5 g of EDC as a cross-linking agent, adjust the pH value to 5, and the temperature to 30 °C. After the reaction, add ethanol for precipitation, then centrifuge, separate the precipitate, and wash to obtain modified sodium hyaluronate;

[0060] (3) Under stirring, slowly add the oil phase to the water phase, and carry out high-speed homogenization stirring in vacuum for 18 min at a rotation speed of 3000 rpm to promote the full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion;

[0061] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of syringa extract. After high-speed homogenization stirring in vacuum for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0062] Comparative Example 1

[0063] A preparation method of a skin cream containing a composite emulsion, comprising the following steps:

[0064] (1) Add 15 g of squalane, 3 g of polyglyceryl-3 polyricinoleate, 1.5 g of glyceryl oleate citrate, and 1.5 g of polyglyceryl-3 diisostearate to a stainless steel oil-phase stirring pot, heat to 70 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0065] (2) Magnetize water using a magnetization device to obtain small-cluster magnetized water. Then add 62 mL of small-cluster magnetized water, 8 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of sodium hyaluronate, and 1 g of carbomer to a stainless steel water-phase stirring pot, heat to 80 °C, and stir evenly to obtain a water phase;

[0066] (3) Under stirring, slowly add the oil phase to the water phase, and carry out high-speed homogenization stirring in vacuum for 18 min at a rotation speed of 3000 rpm to promote the full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion;

[0067] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of syringa extract. After high-speed homogenization stirring in vacuum for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0068] Compared with Example 1, the sodium hyaluronate in Comparative Example 1 was not modified.

[0069] Comparative Example 2

[0070] A preparation method of a skin cream containing a composite emulsion, comprising the following steps:

[0071] (1) Add 15 g of squalane, 3 g of polyglyceryl-3 polyricinoleate, 1.5 g of glyceryl oleate citrate, and 1.5 g of polyglyceryl-3 diisostearate to a stainless-steel oil-phase stirring pot, heat to 70 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0072] (2) Magnetize water using a magnetization device to obtain small-cluster magnetized water. Then, add 62 mL of small-cluster magnetized water, 8 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of modified sodium hyaluronate, and 1 g of carbomer to a stainless-steel water-phase stirring pot, heat to 80 °C, and stir evenly to obtain a water phase;

[0073] The preparation method of the modified sodium hyaluronate comprises the following steps:

[0074] Dissolve 4 g of sodium hyaluronate in deionized water, then add 1 g of ferulic acid to the sodium hyaluronate solution, add 0.6 g of EDC as a cross-linking agent, adjust the pH value to 5, and react at 30 °C. After the reaction, add ethanol for precipitation, then centrifuge, separate the precipitate, and wash to obtain modified sodium hyaluronate;

[0075] (3) Under stirring, slowly add the oil phase to the water phase, and perform high-speed vacuum homogenization stirring for 18 min at a rotation speed of 3000 rpm to promote full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion;

[0076] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of Syringa vulgaris extract. After high-speed vacuum homogenization stirring for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0077] Compared with Example 1, in Comparative Example 2, the sodium hyaluronate solution was not mixed with the sodium alginate solution.

[0078] Comparative Example 3

[0079] A preparation method of a skin cream containing a composite emulsion, comprising the following steps:

[0080] (1) Add 15 g of squalane, 3 g of polyglyceryl-3 polyricinoleate, 1.5 g of glyceryl oleate citrate, and 1.5 g of polyglyceryl-3 diisostearate to a stainless-steel oil-phase stirring pot, heat to 70 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0081] (2) Magnetize water using a magnetization device to obtain magnetized water with small molecular clusters. Then, add 62 mL of magnetized water with small molecular clusters, 8 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of a mixed solution containing sodium hyaluronate, and 1 g of carbomer to a stainless-steel aqueous phase stirring pot, heat to 80 °C, and stir evenly to obtain an aqueous phase;

[0082] The preparation method of the mixed solution containing sodium hyaluronate includes the following steps:

[0083] Add 1 g of sodium alginate to deionized water, stir and dissolve to obtain a sodium alginate solution; dissolve 4 g of sodium hyaluronate in deionized water, and then mix the sodium alginate solution and the sodium hyaluronate solution to obtain a mixed solution;

[0084] (3) Under stirring, slowly add the oil phase to the aqueous phase, and perform vacuum high-speed homogenization stirring for 18 min at a rotation speed of 3000 rpm to promote full emulsification of the oil phase and the aqueous phase to form a stable W / O / W emulsion;

[0085] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of Syringa vulgaris extract. After vacuum high-speed homogenization stirring for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0086] Compared with Example 1, in Comparative Example 3, the mixed solution did not undergo a cross-linking reaction with ferulic acid.

[0087] Comparative Example 4

[0088] A preparation method of a skin cream containing a composite emulsion includes the following steps:

[0089] (1) Add 15 g of squalane, 3 g of polyglyceryl-3 polyricinoleate, 1.5 g of glyceryl oleate citrate, and 1.5 g of polyglyceryl-3 diisostearate to a stainless-steel oil phase stirring pot, heat to 70 °C, and continuously stir until completely mixed and dispersed to obtain an oil phase;

[0090] (2) Magnetize water using a magnetization device to obtain magnetized water with small molecular clusters. Then, add 62 mL of magnetized water with small molecular clusters, 8 g of glycerol, 2 g of bisabolol, 2 g of asiaticoside, 4 g of a sodium hyaluronate mixture, and 1 g of carbomer to a stainless-steel aqueous phase stirring pot, heat to 80 °C, and stir evenly to obtain an aqueous phase;

[0091] The preparation method of the sodium hyaluronate mixture includes the following steps:

[0092] Add 1 g of sodium alginate to deionized water, stir and dissolve to obtain a sodium alginate solution; dissolve 4 g of sodium hyaluronate in deionized water, then mix the sodium alginate solution with the sodium hyaluronate solution to obtain a mixed solution; then add 1 g of ferulic acid to the mixed solution, adjust the pH value to 5, and the temperature to 30 °C. After the reaction, add ethanol for precipitation, then centrifuge, separate the precipitate, and wash to obtain a sodium hyaluronate mixture;

[0093] (3) Under stirring conditions, slowly add the oil phase to the water phase, and perform high-speed vacuum homogenization stirring for 18 min at a rotation speed of 3000 rpm to promote the full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion;

[0094] (4) Vacuum stir the W / O / W emulsion. When the temperature drops to 45 °C, add 0.5 g of phenoxyethanol and 0.6 g of Syringa vulgaris extract. After high-speed vacuum homogenization stirring for 8 min at a rotation speed of 2500 rpm, continuously stir and cool down to 35 °C, filter and discharge to obtain a skin cream containing a composite emulsion.

[0095] Compared with Example 1, in Comparative Example 4, the mixed solution and ferulic acid were only mixed.

[0096] Test methods and results

[0097] (1) Test of stratum corneum water content and transepidermal water loss rate

[0098] Select 35 healthy female volunteers aged 25 - 45 without a history of allergies, and divide them into 7 groups on average to test the skin creams prepared in Examples 1 - 3 and Comparative Examples 1 - 4. All subjects have signed an informed consent form. During the test, the inner sides of the left and right forearms of the subjects were used as the test sites for immediate testing, and the stratum corneum water content of the skin before and 30 min after using the product was compared. The test products were applied once at a dosage of 2.0 ± 0.1 mg / cm 2 . Use a latex finger cot to evenly apply the sample to the test area of (2 cm 2 ×2 cm 2 ), and use skin detectors MPA580 - CM825 and MPA4 - CM825 for testing. The test results are shown in Table 1 below.

[0099] Table 1 Statistical table of stratum corneum water content growth rate and transepidermal water loss rate results

[0100]

[0101] (2) Test of anti - aging performance (antioxidant performance)

[0102] The anti-aging performance (antioxidant performance) of the skin creams prepared in Examples 1-3 and Comparative Examples 1-4 was tested. Test materials and equipment: The skin creams prepared in Examples 1-3 and Comparative Examples 1-4, ethanol, DPPH (analytical pure), AB204-E electronic analytical balance, UV-1600 ultraviolet spectrophotometer. Test method: DPPH shows a dark purple color in absolute ethanol and ethanol-water systems and has a maximum absorption at 514 nm. A free radical scavenger can gradually fade the purple color. The content of DPPH and the scavenging ability of the free radical scavenger for DPPH can be determined based on the change in absorbance.

[0103] Determined by spectrophotometry, the decrease in OD 514 absorption after adding an antioxidant indicates its ability to eliminate organic free radicals. DPPH was first dissolved in a small amount of ethanol solution and prepared into 1×10 -4 mol / L with 10% ethanol and stored in the dark. Take 2 mL of DPPH solution, add 2 mL of skin cream and mix well. After 30 minutes, measure its OD514 at 514 nm (the maximum absorption wavelength). The amount of skin cream required to scavenge 50% of DPPH, i.e., IC 50, was used as an antioxidant index. The scavenging rate P can be calculated using the following formula:

[0104] P = [A0 - (A i - A j )] / A0

[0105] where A0 = the absorbance of the DPPH solution; A i = the absorbance of adding 2 mL of the skin creams prepared in Examples 1-3 and Comparative Examples 1-4 to 2 mL of DPPH solution; A j = the absorbance of adding 2 mL of the skin cream of this example to 2 mL of 10% ethanol solvent.

[0106] The experimental results show that the amount of skin cream required for each example and comparative example to scavenge 50% of DPPH free radicals (1×10 -4 mol / L), i.e., IC 50, is shown in Table 2.

[0107] Table 2 Amount of skin cream required

[0108] Group Required amount (g) Example 1 0.854 Example 2 0.913 Example 3 0.896 Comparative Example 1 2.356 Comparative Example 2 1.582 Comparative Example 3 1.437 Comparative Example 4 1.496

[0109] (3) Stability test of the skin cream

[0110] The pH value is determined according to the method specified in GB / T 13531.1; the viscosity is determined according to the method specified in GB / T 10247-2008; heat resistance test: the heat resistance test is carried out according to the method specified in QB / T 1857-2013. The sample is placed in a constant temperature oven at (40±1)°C for 24 h, and the presence or absence of oil-water separation is observed; cold resistance test: the cold resistance test is carried out according to the method specified in QB / T 1857-2013. The sample is placed in a refrigerator at (-8±2)°C for 24 h. After the skin care cream returns to room temperature, the presence or absence of stratification, coarsening, and discoloration is observed; centrifugation test: the sample with intact packaging is placed in a centrifuge and centrifuged at 2000-4000 revolutions per minute for 30 minutes. After the skin care cream returns to room temperature, the presence or absence of oil-water separation is observed. The test results are shown in Table 3 below.

[0111] Table 3 Stability Test Table of Skin Care Cream

[0112]

[0113]

[0114] It can be seen from the test results in Table 1 above that compared with the skin care creams prepared in Comparative Examples 1-4, the skin care creams prepared in Examples 1-3 of the present invention have better moisturizing performance and better penetration performance; it can be seen from the test results in Table 2 above that the skin care creams prepared in Examples 1-3 of the present invention have outstanding in vitro free radical scavenging ability compared with the skin care creams prepared in Comparative Examples 1-4. The skin care cream prepared by the present invention has more excellent antioxidant performance and anti-aging performance; it can be seen from the test results in Table 3 above that the skin care creams prepared in Examples 1-3 of the present invention have better stability compared with the skin care creams prepared in Comparative Examples 1-4.

[0115] Finally, it should be noted that the above embodiments do not limit the present invention in any form. For those skilled in the art, some modifications and improvements can be made on the basis of the present invention. Therefore, any modification or improvement made without departing from the spirit of the present invention falls within the scope of protection of the present invention.

Claims

1. A skin cream containing a compound emulsion, characterized in that, The skin cream comprises raw materials in the following weight percentages: 15-25% of active oil, 5-10% of emulsifier, 5-10% of humectant, 2-8% of active ingredient, 1-3% of high molecular thickener, 0.2-5% of preservative, and the balance being small molecular cluster magnetized water.

2. The skin cream containing a compound emulsion according to claim 1, characterized in that, The active oil comprises at least one of squalane, glyceryl trioctanoate / decanoate, and cholesterol.

3. The skin care cream containing a composite emulsion according to claim 1, characterized in that, The emulsifier comprises polyglyceryl-3 polyricinoleate, glyceryl oleate citrate, and polyglyceryl-3 diisostearate.

4. The skin care cream containing the composite emulsion according to claim 1, characterized in that, The humectant comprises at least one of glycerol and sorbitol.

5. The skin cream containing the compound emulsion according to claim 1, characterized in that, The active ingredient comprises a first component, a second component, and modified sodium hyaluronate. The first component comprises at least one of bisabolol, arnebia oil, carthamus oil, and coenzyme A. The second component comprises at least one of asiaticoside and panthenol.

6. The skin cream containing a compound emulsion according to claim 5, characterized in that, The preparation method of the modified sodium hyaluronate comprises the following steps: Adding sodium alginate into deionized water, stirring and dissolving to obtain a sodium alginate solution; dissolving sodium hyaluronate in deionized water, then mixing the sodium alginate solution with the sodium hyaluronate solution to obtain a mixed solution; then adding ferulic acid into the mixed solution, adding a crosslinking agent EDC, adjusting the pH value to 4-6, and the temperature to 25-40 °C. After the reaction, adding ethanol for precipitation, then centrifuging, separating the precipitate, and washing to obtain modified sodium hyaluronate.

7. The skin cream containing a compound emulsion according to claim 6, characterized in that, The mass ratio of the sodium alginate, sodium hyaluronate, and ferulic acid is (1-5):(15-20):(3-5).

8. The skin care cream containing the compound emulsion according to claim 1, characterized in that, The high molecular thickener comprises at least one of carbomer, xanthan gum, and cellulose; the preservative comprises at least one of phenoxyethanol, ethylhexylglycerin, caprylyl glycol, pentylene glycol, and symex.

9. The skin cream containing the composite emulsion according to claim 1, wherein, The skin cream further comprises 0.5-0.8% of essence by weight percentage. The essence is refined from at least one of lilac flower, jasmine flower, rose flower, vanilla leaf, bay leaf, litsea cubeba leaf, orange peel, lemon peel, cypress branch, sandalwood branch, camphor root, iris root, pepper seed, fennel seed, mint grass, and lavender.

10. A method for preparing a skin cream containing a composite emulsion according to any one of claims 1 to 9, characterized in that, Comprising the following steps: S1. Adding the active oil and the emulsifier into a stainless steel oil phase stirring pot, heating to 65-75 °C, and continuously stirring to obtain an oil phase; S2. Magnetizing water by a magnetizing device to obtain small molecular cluster magnetized water, then adding the small molecular cluster magnetized water, the humectant, the active ingredient, and the high molecular thickener into a stainless steel water phase stirring pot, heating to 75-85 °C, and stirring evenly to obtain a water phase; S3. Under stirring, slowly adding the oil phase into the water phase, and performing vacuum high-speed homogenizing stirring for 15-20 min to promote the full emulsification of the oil phase and the water phase to form a stable W / O / W emulsion; S4. Vacuum stirring the W / O / W emulsion. When the temperature drops to 44-46 °C, adding the preservative and the essence, performing vacuum high-speed homogenizing stirring for 5-10 min, then continuously stirring and cooling to 34-36 °C, and filtering and discharging to obtain a skin cream containing a composite emulsion.

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