Traditional Chinese medicine composition based on jujube kernels

Abstract

The invention relates to the technical field of medicine penetration, and particularly discloses a jujube kernel-based traditional Chinese medicine composition, which is prepared from the following components by mass: 60g of spina date seed, 60g of albizia flower, 45g of lily, 45g of salvia miltiorrhiza and 30g of honey-fried licorice root, the medicines are ground into powder and blended with vinegar, and the dosage is 20g each time; by combining the synergistic effect of various traditional Chinese medicinal materials, the traditional Chinese medicine composition has the effects of calming the heart, soothing the nerves, resolving depression and relieving restlessness, can effectively relieve depression and anxiety symptoms, performs personalized treatment on the symptoms of different patients, reduces adverse reactions of medicines, and is combined with a traditional Chinese medicine directional medicine penetration instrument, transdermally introduces medicine components and combines physical stimulation such as electricity and heat to achieve the effect of relieving depression and anxiety. The transdermal absorption rate and the curative effect of the medicine are improved, specific acupuncture points are selected for transdermal treatment, the targeting effect of the medicine is enhanced, side effects are reduced, through optimization of a medicine formula and the enhancement effect of the transdermal treatment, a patient can feel the treatment effect more quickly, the treatment enthusiasm is improved, the treatment process is simple and comfortable, and the patient compliance is high.

Description

Technical Field

[0001] The present invention belongs to the technical field of drug transdermal technology, and specifically relates to a traditional Chinese medicine composition based on Ziziphus jujuba seeds. Background Art

[0002] Depression and anxiety disorders are common mental disorders that seriously affect the quality of life and social function of patients. Among them, depression is a mental disorder mainly characterized by significant and persistent low mood. Patients usually show symptoms such as continuous sadness, despair, loss of interest, anhedonia, etc. In severe cases, they may even have suicidal thoughts or behaviors; anxiety disorders are a group of mental disorders mainly characterized by excessive anxiety. Patients usually show continuous tension, worry, uneasiness, and even accompanied by excessive excitement of the autonomic nervous system (such as palpitation, sweating, tremor).

[0003] However, traditional treatment methods mainly include antidepressant drug treatment and psychotherapy. However, drug treatment has certain side effects, such as gastrointestinal discomfort, dizziness, drowsiness, etc., and the compliance of some patients is poor, which affects the treatment effect; psychotherapy such as cognitive behavioral therapy and psychodynamic therapy has a certain effect on depression and anxiety disorders, but it requires a long treatment cycle and has a high requirement for the cooperation of patients. The effect of psychotherapy varies greatly among individuals, and some patients may not achieve ideal treatment effects.

[0004] Therefore, those skilled in the art have proposed a traditional Chinese medicine composition based on Ziziphus jujuba seeds to solve the problems raised in the background art.

[0005] The above information disclosed in this background art is only used to increase the understanding of the background art of the present invention. Therefore, it may include prior art that is not known to those of ordinary skill in the art. Summary of the Invention

[0006] The purpose of the present invention is to provide a traditional Chinese medicine composition based on Ziziphus jujuba seeds to solve the problems of certain side effects in drug treatment, long treatment cycle in psychotherapy, and high requirement for patient cooperation proposed in the above background art.

[0007] To achieve the above purpose, the present invention provides a traditional Chinese medicine composition based on Ziziphus jujuba seeds. The drug formula includes the following components by mass: 60 g of Ziziphus jujuba seeds, 60 g of Albizia julibrissin Durazz., 45 g of Lilium brownii F.E.Br. var. viridulum Baker, 45 g of Salvia miltiorrhiza Bunge, and 30 g of Radix Glycyrrhizae Preparata. The above drugs are ground into powder and mixed with vinegar. The dosage per time is 20 g, 10 g for each of the left and right electrode patches, and 15 consecutive days is a treatment course.

[0008] Preferably, for patients with more depression symptoms, the drug formula further includes 30 g of Bupleurum chinense DC. and 45 g of Curcuma aromatica Salisb.

[0009] Preferably, for patients with anxiety, the drug formula further includes 60 g of dragon's teeth and 30 g of Coptis chinensis

[0010] A preparation method of a Chinese medicine composition based on Ziziphus jujuba seed, the preparation method comprising the following steps:

[0011] S1. Raw material preparation

[0012] Purchase high-quality Chinese medicinal materials, including 60 g of Ziziphus jujuba seed, 60 g of Albizia julibrissin flower, 45 g of Lilium brownii, 45 g of Salvia miltiorrhiza, and 30 g of roasted licorice. For patients with depression, 30 g of Bupleurum chinense and 45 g of Curcuma aromatica also need to be prepared. For patients with anxiety, 60 g of dragon's teeth and 30 g of Coptis chinensis also need to be prepared. Ensure that all medicinal materials meet the pharmacopoeia standards, without impurities and mildew;

[0013] Wash all the medicinal materials separately to remove the dust and impurities on the surface. After washing, dry the medicinal materials in the air or wipe them dry with a clean cloth;

[0014] S2. Medicinal material treatment

[0015] Medicinal material drying: Dry the washed medicinal materials using a low-temperature drying device, control the temperature at 40-60°C, avoid high temperatures from destroying the active ingredients of the medicinal materials, ensure that the medicinal materials are completely dry, and control the moisture content below 10%;

[0016] Medicinal material grinding: Put the dried medicinal materials into a mortar or use a professional Chinese medicine grinder for grinding until the medicinal materials become fine powder, and sieve to ensure that the powder is delicate and uniform without large particle residues;

[0017] S3. Drug mixing

[0018] Basic formula mixing: Mix the ground powders of Ziziphus jujuba seed, Albizia julibrissin flower, Lilium brownii, Salvia miltiorrhiza, and roasted licorice in proportion, 60 g of Ziziphus jujuba seed, 60 g of Albizia julibrissin flower, 45 g of Lilium brownii, 45 g of Salvia miltiorrhiza, and 30 g of roasted licorice, and mix evenly using a stirrer to ensure that all components are fully mixed without obvious stratification or aggregation;

[0019] Formula adjustment for different symptoms:

[0020] For patients with depression: Add the powders of 30 g of Bupleurum chinense and 45 g of Curcuma aromatica to the basic formula and mix evenly again;

[0021] For patients with anxiety: Add the powders of 60 g of dragon's teeth and 30 g of Coptis chinensis to the basic formula and mix evenly again;

[0022] S4. Drug blending

[0023] Prepare a container: Prepare a clean and sterile container for blending the drugs, ensure that the container is dry without residual moisture;

[0024] Harmonize the medicine: Pour the mixed medicine powder into a container, add an appropriate amount of vinegar, and stir evenly to fully mix the medicine powder and vinegar, forming a uniform paste. The harmonized medicine should have a uniform texture without dry powder or lumps.

[0025] S5. Quality control

[0026] Appearance inspection: Check whether the color and texture of the harmonized medicine paste are uniform, and whether there are obvious impurities or foreign matters, ensuring that the medicine paste has no peculiar smell and no deterioration.

[0027] Microbial detection: Conduct microbial detection on the harmonized medicine to ensure that there is no contamination by microorganisms such as bacteria and molds, and the detection results should meet the requirements of national drug standards.

[0028] Component detection: Conduct component detection on the harmonized medicine to ensure that the proportion of each medicinal material component meets the formula requirements, and the detection results should be consistent with the formula design without obvious deviation.

[0029] S6. Packaging and storage

[0030] Subpackage the harmonized medicine paste into sterile small packaging bags or glass bottles, about 20g per portion. The packaging should be well-sealed to prevent the medicine from getting damp and deteriorating. Place the packaged medicine in a cool, dry, and well-ventilated place for storage, avoiding direct sunlight. Control the storage temperature below 20°C and the relative humidity below 60%. Regularly check the quality of the medicine during storage to ensure no deterioration and no dampness.

[0031] A Chinese medicine composition based on Ziziphus jujuba seeds is applied to Chinese medicine ointment.

[0032] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0033] Through the synergistic effect of combining multiple Chinese medicinal materials, the present invention has the effects of calming the mind and relieving uneasiness, and dispelling melancholy and relieving annoyance, can effectively relieve depression and anxiety symptoms, conduct personalized treatment according to the symptoms of different patients, reduce the adverse reactions of the medicine, combine with a Chinese medicine directional transdermal instrument, introduce drug components through transdermal delivery, and combine physical stimuli such as electricity and heat, improve the transdermal absorption rate and curative effect of the medicine, select specific acupoints for transdermal drug treatment, enhance the targeted effect of the medicine, reduce the side effects of the medicine. Through the optimization of the drug formula and the enhancement effect of transdermal drug therapy, patients can feel the treatment effect faster, thereby improving the treatment enthusiasm of patients. The treatment process is simple and comfortable, and the patient compliance is high. Specific implementation manners

[0034] Next, in combination with the embodiments of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0035] Embodiment 1:

[0036] A traditional Chinese medicine composition based on Ziziphus jujuba seeds, and the drug formula includes the following components by mass: 60 g of Ziziphus jujuba seeds, 60 g of Albizia julibrissin Durazz., 45 g of Lilium brownii F.E.Br. var. viridulum Baker, 45 g of Salvia miltiorrhiza Bunge, and 30 g of Radix Glycyrrhizae Preparata. Grind the above drugs into powder, mix them with vinegar, and the dosage per time is 20 g, 10 g for each of the left and right electrode pads. 15 consecutive days is a course of treatment.

[0037] Ziziphus jujuba seeds have the effects of calming the mind and soothing the nerves, nourishing the liver and arresting sweating. Its main components include jujuboside, flavonoid compounds, polysaccharides, etc. Jujuboside can regulate the central nervous system, increase the content of γ-aminobutyric acid (GABA) in the brain, and thus play a sedative and hypnotic role. GABA is an important inhibitory neurotransmitter that can inhibit the excessive excitement of neurons and make the cerebral cortex in a quiet state, thereby achieving the effect of calming the nerves;

[0038] Functions of Ziziphus jujuba seeds:

[0039] 1. Improve sleep quality: The polysaccharide component in Ziziphus jujuba seeds has the effect of regulating the sleep rhythm, which can shorten the sleep onset time, prolong the sleep duration, and improve the sleep quality, and has a significant effect on symptoms such as insomnia and dreaminess;

[0040] 2. Relieve anxiety: By regulating the nervous system and reducing anxiety emotions, the flavonoid compounds in Ziziphus jujuba seeds can regulate the balance of neurotransmitters and reduce the excitability of the nervous system, thereby relieving anxiety emotions;

[0041] 3. Soothe the nerves: Help patients maintain emotional stability and reduce emotional fluctuations. The combined action of various components of Ziziphus jujuba seeds can regulate the function of the emotional center and make the patient's emotions more stable.

[0042] Albizia julibrissin Durazz. has the effects of relieving depression and soothing the nerves, promoting blood circulation and detumescence. Its main components include volatile oils, flavonoid compounds, triterpenoid compounds, etc. The volatile oil component in Albizia julibrissin Durazz. can regulate the nervous system, relieve depression and anxiety. Some components in the volatile oil can enter the brain through the olfactory system and regulate the function of the emotional center, thereby achieving the effect of relieving depression;

[0043] Functions of Albizia julibrissin Durazz.:

[0044] 1. Alleviate depression: It has significant effects on symptoms such as low mood and pessimism. The flavonoid compounds in Albizia julibrissin Durazz. can regulate the balance of neurotransmitters, especially increasing the content of serotonin (5-HT), thereby improving depressive mood.

[0045] 2. Alleviate anxiety: It can relieve anxiety symptoms such as tension and uneasiness. The triterpenoid compounds in Albizia julibrissin Durazz. have a sedative effect, which can reduce the excitability of the nervous system and relieve anxiety symptoms.

[0046] 3. Soothe the nerves: It helps patients maintain emotional stability and reduce mood swings. The combined action of various components in Albizia julibrissin Durazz. can regulate the nervous system and make the patient's mood more stable.

[0047] Lilium brownii F. E. Brown var. viridulum Baker has the effects of nourishing yin and moistening the lungs, and soothing the nerves with a tranquil heart. Its main components include lily glycosides, alkaloids, polysaccharides, etc. Lily glycosides can regulate the nervous system, relieve anxiety and depressive mood. Lily glycosides can play a role in soothing the nerves by regulating the balance of neurotransmitters, especially increasing the content of GABA.

[0048] Functions of Lilium brownii F. E. Brown var. viridulum Baker:

[0049] 1. Alleviate anxiety: It has significant effects on symptoms such as restlessness and anxiety. The alkaloid components in Lilium brownii F. E. Brown var. viridulum Baker can regulate the excitability of the nervous system and relieve anxiety mood.

[0050] 2. Soothe the nerves: It helps patients maintain emotional stability and reduce mood swings. The combined action of various components in Lilium brownii F. E. Brown var. viridulum Baker can regulate the function of the emotional center and make the patient's mood more stable.

[0051] 3. Moisten the lungs: It has an adjuvant therapeutic effect on respiratory discomfort caused by emotional problems. The polysaccharide components in Lilium brownii F. E. Brown var. viridulum Baker have the effect of moistening the lungs and can relieve respiratory discomfort caused by emotional problems, such as dry cough and dry throat.

[0052] Salvia miltiorrhiza Bunge has the effects of promoting blood circulation to remove blood stasis and cooling blood to resolve carbuncles. Its main components include tanshinones, water-soluble phenolic acids, Salvia polysaccharides, etc. Tanshinones can improve microcirculation, increase cerebral blood flow, thereby improving cerebral oxygen supply and relieving depressive and anxiety symptoms. Tanshinones can improve cerebral blood circulation by dilating blood vessels and increasing blood flow.

[0053] Functions of Salvia miltiorrhiza Bunge:

[0054] 1. Improve cerebral blood supply: It has significant effects on symptoms such as dizziness and headache caused by insufficient cerebral blood supply. The water-soluble phenolic acid components in Salvia miltiorrhiza Bunge have antioxidant effects, which can protect vascular endothelial cells and further improve cerebral blood supply.

[0055] 2. Alleviate depression: By improving cerebral blood circulation and reducing depressive mood, danshen can regulate the balance of neurotransmitters, especially increasing the levels of serotonin (5-HT) and norepinephrine (NE), thereby improving depressive mood.

[0056] 3. Alleviate anxiety: Reduce the anxiety symptoms caused by insufficient blood supply to the brain. The polysaccharide component in danshen has the effect of regulating the immune system and can reduce the inflammatory response caused by emotional problems, thereby alleviating anxiety symptoms.

[0057] Prepared licorice root has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, and harmonizing various medicinal herbs. Its main components include glycyrrhizic acid, liquiritin, licorice polysaccharide, etc. Glycyrrhizic acid can regulate the immune system and reduce the inflammatory response, thereby improving the overall physical condition. Liquiritin can reduce the inflammatory response by regulating the activity of immune cells.

[0058] Functions of prepared licorice root:

[0059] 1. Harmonize the properties of medicinal herbs: Act synergistically with other drugs to enhance the overall curative effect. Multiple components in licorice can regulate the properties of other drugs, reduce the adverse reactions of drugs, and enhance the overall curative effect.

[0060] 2. Alleviate fatigue: Have a significant effect on general fatigue caused by depression and anxiety. Glycyrrhizic acid can regulate gastrointestinal motility and enhance digestive function, thereby reducing fatigue caused by weakness of the spleen and stomach.

[0061] 3. Protect the gastric mucosa: Reduce the stimulation of drugs on the stomach and reduce gastrointestinal discomfort. Licorice polysaccharide can adhere to the surface of the gastric mucosa to form a protective layer, reducing the direct stimulation of drugs on the gastric mucosa.

[0062] Furthermore, for patients with a tendency towards depression, the drug formula also includes 30g of bupleurum root and 45g of turmeric root tuber.

[0063] Bupleurum root has the effects of soothing the liver and relieving depression, lifting yang and raising qi. Its main components include saikosaponins, bupleurum polysaccharide, etc. Saikosaponins can regulate the nervous system and relieve the depressive mood caused by stagnation of liver qi. Saikosaponins can regulate the balance of neurotransmitters, especially increasing the content of serotonin (5-HT), thereby relieving the depressive mood caused by stagnation of liver qi.

[0064] Functions of bupleurum root:

[0065] 1. Alleviate depression: Have a significant effect on patients with depression due to stagnation of liver qi. Bupleurum root can regulate the function of the emotional center and improve symptoms such as low mood and distension in the chest and hypochondrium.

[0066] 2. Regulate emotions: Help patients relieve symptoms such as low mood and distension in the chest and hypochondrium. The polysaccharide component in bupleurum root can regulate the immune system and reduce the inflammatory response caused by emotional problems, thereby regulating emotions.

[0067] Curcuma aromatica Salisb. has the effects of promoting qi and relieving depression, cooling blood and resolving stasis. Its main components include curcumin, volatile oil, Curcuma aromatica Salisb. polysaccharide, etc. Curcumin can regulate the nervous system and relieve depression and anxiety. Curcumin can relieve depression and anxiety by regulating the balance of neurotransmitters, especially by increasing the content of serotonin (5-HT) and norepinephrine (NE).

[0068] Functions of Curcuma aromatica Salisb.:

[0069] 1. Relieving depression: It has a significant effect on patients with depression due to stagnation of liver qi. Curcuma aromatica Salisb. can regulate the function of the emotional center and improve symptoms such as low mood and fullness in the chest and hypochondrium.

[0070] 2. Relieving anxiety: It can relieve the anxiety symptoms caused by stagnation of liver qi. The volatile oil component in Curcuma aromatica Salisb. can enter the brain through the olfactory system and regulate the function of the emotional center, thereby relieving anxiety symptoms.

[0071] Preferably, for patients with a tendency to anxiety, the drug formula also includes 60 g of Odontotomi, 30 g of Coptis chinensis Franch.

[0072] Odontotomi has the effects of calming the mind and suppressing hyperactive liver-yang. Its main components include various minerals and trace elements, Odontotomi polysaccharide, etc. Odontotomi can regulate the nervous system and relieve anxiety and insomnia symptoms. Odontotomi can play a sedative role by regulating the balance of neurotransmitters, especially by increasing the content of GABA.

[0073] Functions of Odontotomi:

[0074] 1. Relieving anxiety: It has a significant effect on patients with anxiety disorder. Odontotomi can regulate the function of the emotional center and relieve anxiety symptoms such as tension and uneasiness.

[0075] 2. Improving sleep: It can help patients improve sleep quality and reduce insomnia. The polysaccharide component in Odontotomi can regulate the sleep rhythm, shorten the sleep onset time, and prolong the sleep duration.

[0076] Coptis chinensis Franch. has the effects of clearing away heat and drying dampness, purging fire and detoxifying. Its main components include berberine, Coptis chinensis Franch. polysaccharide, etc. Berberine can regulate the nervous system and relieve anxiety and restlessness. Berberine can relieve anxiety and restlessness by regulating the balance of neurotransmitters, especially by increasing the content of GABA.

[0077] Functions of Coptis chinensis Franch.:

[0078] 1. Relieving anxiety: It has a significant effect on patients with anxiety disorder. Coptis chinensis Franch. can regulate the function of the emotional center and relieve anxiety symptoms such as tension and uneasiness.

[0079] 2. Clearing heat and detoxifying: Alleviating the internal heat symptoms caused by emotional problems. The polysaccharide components in Coptis chinensis can regulate the immune system, reduce the inflammatory response caused by emotional problems, and thus alleviate the internal heat symptoms.

[0080] Furthermore, a preparation method of a Chinese medicinal composition based on Ziziphus jujuba seed includes the following steps:

[0081] S1. Raw material preparation

[0082] Purchase high-quality Chinese medicinal materials, including 60g of Ziziphus jujuba seed, 60g of Albizia julibrissin flower, 45g of Lilium brownii, 45g of Salvia miltiorrhiza, and 30g of honey-fried licorice root. For patients with more depressive symptoms, 30g of Bupleurum chinense and 45g of Curcuma aromatica Salisb. are also needed to be prepared. For patients with more anxiety symptoms, 60g of Dragon's Teeth and 30g of Coptis chinensis are also needed to be prepared. Ensure that all medicinal materials meet the pharmacopoeia standards, without impurities and mildew.

[0083] Wash all the medicinal materials separately, removing the dust and impurities on the surface. After washing, dry the medicinal materials in the air or wipe them dry with a clean cloth.

[0084] S2. Medicinal material processing

[0085] Medicinal material drying: Use a low-temperature drying equipment to dry the washed medicinal materials, control the temperature at 40 - 60°C, avoid high temperature from destroying the effective components of the medicinal materials, ensure that the medicinal materials are completely dry, and control the moisture content below 10%.

[0086] Medicinal material grinding: Put the dried medicinal materials into a mortar or use a professional Chinese medicine grinder to grind them until they become fine powder, and sieve them to ensure that the powder is delicate and uniform without large particle residues.

[0087] S3. Drug mixing

[0088] Basic formula mixing: Mix the ground powders of Ziziphus jujuba seed, Albizia julibrissin flower, Lilium brownii, Salvia miltiorrhiza, and honey-fried licorice root according to the ratio of 60g of Ziziphus jujuba seed, 60g of Albizia julibrissin flower, 45g of Lilium brownii, 45g of Salvia miltiorrhiza, and 30g of honey-fried licorice root evenly, and use a stirrer to stir to ensure that all components are fully mixed without obvious stratification or aggregation.

[0089] Formula adjustment for different symptoms:

[0090] For patients with more depressive symptoms: Add the powders of 30g of Bupleurum chinense and 45g of Curcuma aromatica Salisb. to the basic formula and mix evenly again.

[0091] For patients with more anxiety symptoms: Add the powders of 60g of Dragon's Teeth and 30g of Coptis chinensis to the basic formula and mix evenly again.

[0092] S4. Drug blending

[0093] Preparation of the container: Prepare a clean and sterile container for mixing the medicine, ensuring that the container is dry and free of residual moisture;

[0094] Mixing the medicine: Pour the mixed medicine powder into the container, add an appropriate amount of vinegar, and stir evenly to fully mix the medicine powder with the vinegar to form a uniform paste. The mixed medicine should have a uniform texture without dry powder or lumps;

[0095] S5. Quality control

[0096] Appearance inspection: Check the color and texture of the mixed medicine paste for uniformity, and check for any obvious impurities or foreign objects. Ensure that the medicine paste has no strange smell and is not spoiled;

[0097] Microbial detection: Conduct microbial detection on the mixed medicine to ensure that there is no contamination by microorganisms such as bacteria and molds. The detection results should meet the requirements of national drug standards;

[0098] Ingredient detection: Conduct ingredient detection on the mixed medicine to ensure that the proportion of each medicinal ingredient meets the requirements of the formula. The detection results should be consistent with the formula design without obvious deviations;

[0099] S6. Packaging and storage

[0100] Divide the mixed medicine paste into sterile small packaging bags or glass bottles, about 20 g per portion. The packaging should be well-sealed to prevent the medicine from getting damp and spoiled. Store the packaged medicine in a cool, dry, and well-ventilated place, avoiding direct sunlight. Control the storage temperature below 20°C and the relative humidity below 60%. Regularly check the quality of the medicine during storage to ensure that there is no spoilage or dampness.

[0101] Furthermore, for the above method of using a traditional Chinese medicine composition based on Ziziphus jujuba seed combined with a traditional Chinese medicine directional transdermal therapy instrument, the transdermal therapy includes the following steps:

[0102] 1. Use a traditional Chinese medicine directional transdermal therapy instrument and prepare disposable physiotherapy electrode pads;

[0103] 2. Select acupoints such as Neiguan (PC6), Xinshu (BL15), Shenmen (HT7), Laogong (PC8), Yongquan (KI1) for transdermal therapy;

[0104] Neiguan (PC6): Located on the palmar side of the forearm, on the line connecting Quze (PC3) and Daling (PC7), 2 cun above the wrist crease, between the palmaris longus tendon and the flexor carpi radialis tendon;

[0105] Xinshu (BL15): Located on the back, below the spinous process of the 5th thoracic vertebra, 1.5 cun lateral to it;

[0106] Shenmen (HT7): Located on the wrist, at the ulnar end of the transverse crease on the palmar side of the wrist, in the depression on the radial side of the flexor carpi ulnaris tendon;

[0107] Laogong Point: Located in the center of the palm, between the 2nd and 3rd metacarpal bones, closer to the 3rd metacarpal bone, at the tip of the middle finger when making a fist;

[0108] Yongquan Point: Located in the anterior depression of the foot, at the anterior one-third of the line connecting the head of the webbing between the 2nd and 3rd toes and the heel;

[0109] For those with more depression symptoms, Taichong Point (located on the dorsal side of the foot, in the depression behind the 1st metatarsal space) can be added. For those with more anxiety symptoms, (other relevant acupoints can be selected according to actual needs);

[0110] Select specific acupoints for transdermal drug therapy. These acupoints are closely related to the heart, nervous system, etc. By stimulating these acupoints, the function of the nervous system is regulated, the blood circulation of the heart and brain is improved, thus relieving depression and anxiety symptoms. Acupoint stimulation can enhance the targeted effect of drug components and improve the treatment effect;

[0111] 3. Mix the drug powder with vinegar to form a paste. Vinegar can help the drug components better penetrate the skin. The drug is evenly applied on the electrode patch and pasted on the selected acupoints, ensuring that the electrode patch fits tightly with the skin. Using the skin's permeability, the drug components gradually penetrate into the subcutaneous tissue. The drug components absorbed through the skin can directly enter the blood circulation, thus playing a therapeutic role;

[0112] 4. Connect the power supply and adjust the current intensity and heat according to the patient's tolerance. Generally, the heat is adjusted to make the patient feel comfortable. Adjust the heat of the device to increase the skin surface temperature, further promoting the penetration and absorption of drug components. Heat stimulation can relieve muscle tension, reduce pain and discomfort. The current intensity can be appropriately adjusted according to the patient's reaction. The current generated by the Chinese medicine directional transdermal therapy instrument can stimulate the skin and acupoints, promote local blood circulation, enhance the penetration and absorption of drug components. Each treatment lasts for 20 - 30 minutes, once a day, and 15 consecutive days is a treatment course.

[0113] The evaluation of the treatment effect includes using the Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA) to score the patient's depression and anxiety symptoms, and calculating the reduction rate to evaluate the treatment effect.

[0114] Use the Hamilton Depression Scale and the Hamilton Anxiety Scale to score the patient's depression and anxiety symptoms before treatment, at the 1st week, 3rd week, 6th week, and 15th week after treatment. The formula for calculating the reduction rate is: (score before treatment - score after treatment) / score before treatment × 100%;

[0115] According to the reduction rate, the curative effects are divided into: cured (reduction rate ≥ 75%), markedly effective (75% > reduction rate ≥ 50%), effective (50% > reduction rate ≥ 25%), ineffective (reduction rate < 25%).

[0116] Hamilton Depression Rating Scale (HAMD):

[0117]

[0118]

[0119] Hamilton Anxiety Rating Scale (HAMA):

[0120]

[0121] The HAMD and HAMA are standardized scales that have undergone rigorous scientific validation. Their scoring criteria and assessment methods have been widely verified and applied in numerous studies and clinical practices.

[0122] The scoring systems of these scales have high reliability and validity, and can accurately reflect the severity of patients' depressive and anxiety symptoms.

[0123] HAMD: When assessing depressive symptoms, scores are given from multiple dimensions such as mood, somatic symptoms, and cognitive function. For example, core depressive symptoms such as low mood, loss of interest, sleep disorders, appetite changes, self-blame and self-condemnation, as well as somatic symptoms (such as fatigue, constipation or diarrhea, headache, etc.) and cognitive function disorders (such as inattention, memory loss, etc.) are evaluated. It not only assesses patients' core depressive symptoms, but also covers somatic symptoms and cognitive function disorders related to depression. This comprehensive assessment helps doctors fully understand the patient's condition and formulate more precise treatment plans.

[0124] HAMA: When assessing anxiety symptoms, scores are given from two main dimensions: physical anxiety (such as palpitation, chest tightness, sweating, etc.) and mental anxiety (such as worry, tension, uneasiness, etc.). At the same time, it also includes the assessment of the severity of anxiety symptoms (such as mild, moderate, severe) and duration (such as occasional, frequent, persistent). It not only assesses physical and mental anxiety, but also evaluates the severity and duration of anxiety symptoms. This systematic assessment helps doctors more accurately judge the type and degree of anxiety symptoms.

[0125] Through a specific scoring system, the severity of patients' symptoms is quantified into specific scores, which is convenient for doctors and researchers to objectively and accurately assess the patient's condition. During the treatment process, regularly using the HAMD and HAMA to score patients can dynamically monitor the changes in patients' symptoms. For example, scoring before treatment, at the 1st week, 3rd week, 6th week, and 15th week after treatment can visually observe the improvement of patients' symptoms. By comparing the scores at different time points, doctors can timely adjust the treatment plan to ensure the maximization of treatment effects.

[0126] It can be seen from this that mild to moderate depression patients are selected, without severe heart, liver, and kidney dysfunctions, without skin breakage or infection. Weigh 60 g of Semen Ziziphi Spinosae, 60 g of Flos Albiziae, 45 g of Bulbus Lilii, 45 g of Radix Salviae Miltiorrhizae, and 30 g of Radix Glycyrrhizae Preparata according to the basic formula. Grind the above-mentioned drugs into powder, and mix them into a paste with vinegar. The dosage each time is 20 g (10 g for each of the left and right electrode pads). 15 consecutive days is a treatment course. Use a traditional Chinese medicine directional transdermal therapy instrument (such as the WNDZZ-2TD type directional medicine penetration instrument or other similar devices), ensure the normal operation of the device, keep the electrode pads clean and undamaged. Use the Hamilton Depression Rating Scale (HAMD) to score the patients, explain the treatment process and precautions to the patients, and sign the informed consent form. Select the Neiguan acupoint, Xinshu acupoint, Shenmen acupoint, Laogong acupoint, and Yongquan acupoint for transdermal therapy. Evenly apply the mixed drug powder on the electrode pads, and stick the electrode pads on the selected acupoints respectively, ensuring close contact between the electrode pads and the skin. Connect the power supply, and adjust the current intensity and heat according to the patient's tolerance. Generally, adjust the heat to make the patient feel comfortable, and the current intensity can be appropriately adjusted according to the patient's reaction. Each treatment time is 20 - 30 minutes, once a day, and 15 consecutive days is a treatment course. During the treatment process, closely observe the patient's reactions, including skin conditions, discomfort, etc. If the patient has discomfort symptoms such as skin allergy, itching, pain, etc., the current intensity should be adjusted in time or the treatment should be suspended, and symptomatic treatment should be given if necessary. After the treatment, guide the patient to clean the treatment area and keep the skin dry. Before the treatment, at the 1st week, 3rd week, 6th week, and 15th week after the treatment, use the Hamilton Depression Rating Scale (HAMD) to score the patient's depressive symptoms.

[0127] Example 2:

[0128] Basically, the operation is the same as that in Example 1. Among them, patients with partial depression are selected for treatment. Add 30 g of Radix Bupleuri and 45 g of Radix Curcumae to the basic formula. Grind the above-mentioned drugs into powder, and mix them into a paste with vinegar. The dosage each time is 20 g (10 g for each of the left and right electrode pads). 15 consecutive days is a treatment course. The acupoints are different from the basic selected acupoints. Select the Neiguan acupoint, Xinshu acupoint, Shenmen acupoint, Laogong acupoint, Yongquan acupoint, and Taichong acupoint for transdermal therapy. During the treatment process, adjust the current intensity and heat according to the patient's reaction to ensure the patient's comfort. Before the treatment, at the 1st week, 3rd week, 6th week, and 15th week after the treatment, use the Hamilton Depression Rating Scale (HAMD) to score, and record the improvement of the patient's symptoms and the incidence of adverse reactions.

[0129] Example 3:

[0130] Basically the same as the operation in the first embodiment, in which patients with partial depression are selected for treatment, 60 g of dragon's teeth and 30 g of Coptis chinensis are added to the basic formula. The above-mentioned drugs are ground into powder and mixed into a paste with vinegar. The dosage each time is 20 g (10 g for each of the left and right electrode pads). 15 consecutive days are taken as a course of treatment. The Neiguan point, Xinshu point, Shenmen point, Laogong point, and Yongquan point are selected for transdermal drug treatment. During the treatment process, the current intensity and heat are adjusted according to the patient's reaction to ensure the patient's comfort. Before treatment, at the 1st week, 3rd week, 6th week, and 15th week after treatment, the Hamilton Anxiety Scale (HAMA) is used for scoring, and the improvement of the patient's symptoms and the incidence of adverse reactions are recorded.

[0131] In summary, through the synergistic effect of combining multiple Chinese medicinal materials, the present invention has the effects of calming the mind and relieving uneasiness, and can effectively relieve depression and anxiety symptoms. It conducts personalized treatment according to the symptoms of different patients, reduces the adverse reactions of drugs. The traditional Chinese medicine directional transdermal drug therapy improves the transdermal absorption rate and curative effect of drugs by transdermally introducing drug components and combining physical stimuli such as electricity and heat. Selecting specific acupoints for transdermal drug treatment enhances the targeting effect of drugs and reduces the side effects of drugs. Through the optimization of the drug formula and the enhancement effect of the transdermal drug therapy, patients can feel the treatment effect faster, thereby improving the treatment enthusiasm of patients. The treatment process is simple and comfortable, and the patient compliance is high.

[0132] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the scope of the claims of the present invention.

Claims

1. A Chinese medicinal composition based on zizyphus jujuba seeds, characterized in that, The described drug formula includes the following components by mass: 60g of wild jujube seeds, 60g of silk tree flowers, 45g of lilies, 45g of salvia miltiorrhiza, and 30g of roasted licorice root. Grind the above-mentioned drugs into powder, mix them with vinegar, with a dosage of 20g each time, 10g for each of the left and right electrode patches, and 15 consecutive days as a treatment course.

2. The traditional Chinese medicine composition based on Ziziphus jujuba seeds according to claim 1, wherein: For patients with a tendency to depression, the drug formula further includes 30g of bupleurum root and 45g of turmeric root.

3. The Chinese medicine composition based on zizyphus jujuba seeds according to claim 1, wherein: For patients with a tendency to anxiety, the drug formula further includes 60g of dragon's teeth and 30g of coptis root.

4. A preparation method of a traditional Chinese medicine composition based on zizyphus jujuba seeds, characterized in that, The preparation method includes the following steps: S1. Raw material preparation Purchase high-quality Chinese medicinal materials, including 60g of wild jujube seeds, 60g of silk tree flowers, 45g of lilies, 45g of salvia miltiorrhiza, and 30g of roasted licorice root. For patients with a tendency to depression, 30g of bupleurum root and 45g of turmeric root also need to be prepared. For patients with a tendency to anxiety, 60g of dragon's teeth and 30g of coptis root also need to be prepared. Ensure that all medicinal materials meet the pharmacopoeia standards, without impurities or mildew; Wash all the medicinal materials separately, remove the dust and impurities on the surface. After washing, dry the medicinal materials in the air or dry them with a clean cloth. S2. Medicinal material processing Medicinal material drying: Use a low-temperature drying equipment to dry the washed medicinal materials, control the temperature at 40 - 60°C, avoid destroying the active ingredients of the medicinal materials at high temperature, ensure that the medicinal materials are completely dry, and control the moisture content below 10%; Medicinal material grinding: Put the dried medicinal materials into a mortar or use a professional traditional Chinese medicine grinder for grinding until the medicinal materials become fine powder, and sieve them to ensure that the powder is delicate and uniform without large particle residues; S3. Drug mixing Basic formula mixing: Mix the ground powders of wild jujube seeds, silk tree flowers, lilies, salvia miltiorrhiza, and roasted licorice root in proportion, 60g of wild jujube seeds, 60g of silk tree flowers, 45g of lilies, 45g of salvia miltiorrhiza, and 30g of roasted licorice root, and mix them evenly with a stirrer to ensure that all components are fully mixed without obvious stratification or aggregation; Formula adjustment for different symptoms: For patients with a tendency to depression: Add the powders of 30g of bupleurum root and 45g of turmeric root to the basic formula and mix them evenly again; For patients with a tendency to anxiety: Add the powders of 60g of dragon's teeth and 30g of coptis root to the basic formula and mix them evenly again; S4. Drug blending Prepare a container: Prepare a clean and sterile container for blending the drugs, ensure that the container is dry without water residue; Blend the drugs: Pour the mixed drug powder into the container, add an appropriate amount of vinegar, and stir evenly to make the drug powder and vinegar fully mixed to form a uniform paste. The blended drug should have a uniform texture without dry powder or caking; S5. Quality control Appearance inspection: Check the color and texture of the blended drug paste to see if they are uniform, without obvious impurities or foreign objects, and ensure that the drug paste has no peculiar smell or deterioration; Microbial detection: Conduct microbial detection on the blended drugs to ensure that there is no contamination by bacteria, molds and other microorganisms, and the detection results should meet the requirements of national drug standards; Component detection: Conduct component detection on the blended drugs to ensure that the proportion of each medicinal material component meets the formula requirements, and the detection results should be consistent with the formula design without obvious deviation; S6. Packaging and storage The well-mixed medicinal paste is divided and packed into sterile small packaging bags or glass bottles, about 20 g per portion. The packaging should be well-sealed to prevent the medicine from getting damp and deteriorating. The packaged medicine should be stored in a cool, dry and well-ventilated place, avoiding direct sunlight. The storage temperature should be controlled below 20 °C and the relative humidity below 60%. During storage, regularly check the quality of the medicine to ensure that there is no deterioration or dampness.

5. The application of a Chinese medicine composition based on Ziziphus jujuba seed according to any one of claims 1-3 in a Chinese medicine ointment.

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