Anti-pigment drug dressing as well as preparation method and use method thereof

Abstract

The invention discloses a relapse anti-pigment and anti-scar drug dressing and a preparation method and a use method thereof, and relates to the technical field of medical dressings, the relapse anti-pigment and anti-scar drug dressing comprises a dressing matrix drug bag and a supplement bag, the dressing matrix drug bag is filled with dressing matrix drug slurry, and the amount of the supplement bag is calculated according to each part of the dressing. The dressing matrix medicine slurry is composed of 1-2 g of tranexamic acid, 1-3 g of vitamin B3, 1-3 g of vitamin E, 8-12 g of gallnut, 12-16 g of salvia miltiorrhiza, 4-8 g of angelica sinensis, 4-5 g of moutan bark and 15-30 ml of sterilized normal saline, and 1-3 g of vitamin C and 8-12 g of xanthan gum are contained in the supplement bag. The dressing obtained by the invention has excellent depigmentation and scar prevention effects on burnt and healed skin.

Description

Technical Field

[0001] The present invention relates to the technical field of medical dressings, and particularly relates to an anti-pigmentation drug dressing, a preparation method thereof, and a using method thereof. Background Art

[0002] Pigmentation will occur in the late stage of wound healing after second-degree burns, third-degree burns, and skin grafting. Lighter pigmentation requires a recovery period of 3 to 6 months, and severe cases may result in permanent pigmentation or even pigment loss. To restore a uniform skin color, surgical intervention is required. Thus, it can be seen the importance of depigmentation during the wound healing process after burns.

[0003] The commonly used depigmentation drug on the market at present is hydroquinone ointment. This ointment has good depigmentation performance. However, if this ointment is used too early, it will cause pain and even allergic reactions in the patient's wound. In addition, using this ointment for too long may also lead to pigment loss and allergic conditions. It can be seen that although hydroquinone ointment has good depigmentation performance, its performance is unstable, and it is very difficult to control the timing and duration of use. For the operation of depigmentation after burn wound healing, drug subcutaneous injection combined with laser treatment is also used clinically for anti-scarring. However, subcutaneous injection cannot meet the treatment of extensive facial and trunk scars, and simple laser treatment has unsatisfactory effects in terms of depigmentation.

[0004] There are many existing products for skin whitening in dressings. Perhaps applying dressings during the wound healing process after burns is also a good way to depigment. However, the skin during the wound healing process after burns is delicate and easily irritated. At present, there is no special dressing for depigmentation in the late stage of burns on the market. Ordinary whitening dressings have more chemical substances and strong irritation, and the newly healed skin after burns cannot bear them, easily leading to skin allergies or even re-ulceration. Moreover, ordinary whitening dressings have unsatisfactory effects on pigment deposition after burns. Therefore, it is still difficult to solve the problem of pigmentation by applying dressings during the wound healing process after burns. Summary of the Invention

[0005] In view of the above problems in the prior art, the present invention provides an anti-pigmentation drug dressing to solve the technical problems that existing dressings have strong irritation to the wound after burns and unsatisfactory depigmentation effects.

[0006] The technical solution adopted by the present invention is as follows:

[0007] An anti-pigmentation drug dressing, comprising a dressing matrix medicine bag and a supplement bag. The dressing matrix medicine bag contains a dressing matrix medicine pulp. Calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1-2 g of tranexamic acid, 1-3 g of vitamin B3, 1-3 g of vitamin E, 8-12 g of Chinese gallnut, 12-16 g of Salvia miltiorrhiza, 4-8 g of Angelica sinensis, 4-5 g of Cortex Moutan, and 15-30 ml of sterile physiological saline. The supplement bag contains 1-3 g of vitamin C and 8-12 g of xanthan gum.

[0008] Further, calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1.2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile physiological saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

[0009] Further, calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile physiological saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

[0010] Further, calculated per portion of the dressing, the dressing matrix medicine pulp consists of 2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile physiological saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

[0011] A preparation method of an anti-pigmentation drug dressing, comprising the following steps:

[0012] (1) Uniformly disperse tranexamic acid, vitamin B3, vitamin E, Chinese gallnut powder, Salvia miltiorrhiza powder, Angelica sinensis powder, and Cortex Moutan powder in sterile physiological saline to obtain a medicine pulp, and encapsulate the medicine liquid in a sterile environment to obtain a dressing matrix medicine bag;

[0013] (2) Sterilely encapsulate vitamin C and xanthan gum separately and then encapsulate them into the same bag to obtain a supplement bag.

[0014] A using method of an anti-pigmentation drug dressing, comprising the following steps:

[0015] (1) Open the dressing matrix medicine bag, add vitamin C in the supplement bag, and then repeatedly squeeze and knead the dressing matrix medicine bag so that vitamin C and each component of the medicine pulp are uniformly dispersed;

[0016] (2) Add xanthan gum in the supplement bag to the system, and repeatedly squeeze and knead the dressing matrix medicine bag until it forms a gel state, then it can be used as a dressing.

[0017] In summary, compared with the prior art, the present invention has the following advantages and beneficial effects:

[0018] 1. The present invention utilizes a specific formulation to form a slightly acidic environment with vitamin C, obtaining a dressing suitable for the healing of burn skin. The obtained dressing has low irritation and excellent effects in depigmenting and removing scars on the healed burn skin, solving the technical problems of strong irritation of existing dressings to burn wounds and unsatisfactory depigmentation effects.

[0019] 2. The present invention ensures the stability of the dressing effect by separately packaging vitamin C that is unstable under neutral conditions and supplementing it into the dressing only during use. Detailed implementation modes

[0020] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with various embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention, that is, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.

[0021] The special term "embodiment" here, any embodiment described as "exemplary" does not have to be interpreted as superior to or better than other embodiments. For the performance index tests in the embodiments of the present method, unless otherwise specified, the conventional test methods in the art are adopted. The terms described in the present invention are only used to describe special implementation modes and are not used to limit the content disclosed in the present invention.

[0022] Unless otherwise specified, the technical and scientific terms used herein have the same meanings as those commonly understood by those of ordinary skill in the technical field to which the present invention belongs; other raw materials, reagents, test methods and technical means not specifically noted in the present invention refer to the raw materials and reagents commonly used by those of ordinary skill in the art, as well as the experimental methods and technical means commonly adopted.

[0023] Embodiment 1

[0024] This embodiment provides an anti-pigmentation drug dressing, which includes a dressing matrix medicine bag and a supplement bag. The dressing matrix medicine bag contains a dressing matrix medicine paste. Calculated per portion of the dressing, the dressing matrix medicine paste is composed of 1.2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of salvia miltiorrhiza, 5 g of angelica sinensis, 3 g of moutan bark, and 10 ml of sterilized normal saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum. The preparation steps are as follows:

[0025] (1) Grind 1.2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of galla chinensis powder, 15 g of salvia miltiorrhiza powder, 5 g of angelica sinensis powder, and 3 g of moutan cortex powder, and uniformly disperse them in 20 ml of sterilized physiological saline to obtain a medicinal pulp. Then, under a sterile environment, encapsulate the medicinal liquid to obtain a dressing matrix medicine bag;

[0026] (2) Sterilely encapsulate 2 g of vitamin C and 10 g of xanthan gum separately, and then encapsulate them into the same bag to obtain a supplement bag.

[0027] The anti-pigmentation drug dressing prepared in this example has the following usage steps:

[0028] (1) Open the dressing matrix medicine bag, add vitamin C from the supplement bag, and then repeatedly squeeze and knead the dressing matrix medicine bag so that vitamin C and each component of the medicinal pulp are uniformly dispersed;

[0029] (2) Add xanthan gum from the supplement bag into the system, and repeatedly squeeze and knead the dressing matrix medicine bag until it forms a gel state, then it can be used as a dressing.

[0030] The dressing prepared in this example can be applied to the skin of any part of burn wound healing, including hands, face, chest, etc., and can also be used as a non-irritating whitening mask.

[0031] Example 2

[0032] This example provides an anti-pigmentation drug dressing, including a dressing matrix medicine bag and a supplement bag. The dressing matrix medicine bag contains a dressing matrix medicinal pulp. Calculated per portion of the dressing, the dressing matrix medicinal pulp is composed of 1 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of galla chinensis, 15 g of salvia miltiorrhiza, 5 g of angelica sinensis, 3 g of moutan cortex, and 10 ml of sterilized physiological saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum. Its preparation steps are the same as those in Example 1.

[0033] Example 3

[0034] This example provides an anti-pigmentation drug dressing, including a dressing matrix medicine bag and a supplement bag. The dressing matrix medicine bag contains a dressing matrix medicinal pulp. Calculated per portion of the dressing, the dressing matrix medicinal pulp is composed of 2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of galla chinensis, 15 g of salvia miltiorrhiza, 5 g of angelica sinensis, 3 g of moutan cortex, and 10 ml of sterilized physiological saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum. Its preparation steps are the same as those in Example 1.

[0035] Control Example 1

[0036] In order to investigate the influence of each component on the depigmentation effect of the dressing, the following control groups were set up:

[0037] The preparation process of the dressing in Group A is as follows:

[0038] (1) Dissolve 1.2 g of tranexamic acid, 2 g of vitamin E, 10 g of ground gallnut powder, 15 g of ground salvia miltiorrhiza powder, 5 g of ground angelica sinensis powder, and 3 g of ground moutan cortex powder evenly in 20 ml of sterile physiological saline to obtain a medicinal pulp, and encapsulate the medicinal liquid in a sterile environment to obtain a dressing matrix medicine bag;

[0039] (2) Sterilely encapsulate 2 g of vitamin C and 10 g of xanthan gum respectively and then encapsulate them into the same bag to obtain a supplement bag.

[0040] The preparation process of the dressing in Group B is as follows:

[0041] (1) Dissolve 1.2 g of tranexamic acid, 2 g of vitamin B3, 10 g of ground gallnut powder, 15 g of ground salvia miltiorrhiza powder, 5 g of ground angelica sinensis powder, and 3 g of ground moutan cortex powder evenly in 20 ml of sterile physiological saline to obtain a medicinal pulp, and encapsulate the medicinal liquid in a sterile environment to obtain a dressing matrix medicine bag;

[0042] (2) Sterilely encapsulate 2 g of vitamin C and 10 g of xanthan gum respectively and then encapsulate them into the same bag to obtain a supplement bag.

[0043] The dressing in Group C does not have a supplement bag, and the dressing matrix bag is the same as that in Example 1.

[0044] The preparation process of the dressing in Group D is as follows:

[0045] (1) Dissolve 2 g of vitamin B3, 2 g of vitamin E, 10 g of ground gallnut powder, 15 g of ground salvia miltiorrhiza powder, 5 g of ground angelica sinensis powder, and 3 g of ground moutan cortex powder evenly in 20 ml of sterile physiological saline to obtain a medicinal pulp, and encapsulate the medicinal liquid in a sterile environment to obtain a dressing matrix medicine bag;

[0046] (2) Sterilely encapsulate 2 g of vitamin C and 10 g of xanthan gum respectively and then encapsulate them into the same bag to obtain a supplement bag.

[0047] Effect evaluation test:

[0048] Subjects: Select 90 patients with hand burns for 5 - 10 days, with the burn degree being deep second-degree burns, and the wound size being between 2 - 5 cm in diameter. The exclusion criteria for the subjects meet the "Diagnostic Criteria and Management Principles for Cosmetic Contact Dermatitis" of GB17149.2 - 1997, and none of the subjects have severe systemic diseases, immune deficiencies or autoimmune diseases, nor active allergic diseases and a history of allergies to skin care cosmetics, are not pregnant or lactating, and have no ethical taboos.

[0049] The test process is as follows:

[0050] (1) The subjects were divided into 9 groups: experimental group 1, experimental group 2, experimental group 3, control group A, control group B, control group C, control group D, control group E, and blank control group, with 10 people in each group.

[0051] (2) The dressing was applied to the subjects once every two days. First, according to the usage steps of Example 1, the dressing prepared in Example 1 was applied to experimental group 1, the dressing prepared in Example 2 was applied to experimental group 2, and the dressing prepared in Example 3 was applied to experimental group 3; the dressing of group A was applied to group A, the dressing of group B was applied to group B, the dressing of group C was applied to group C, and the dressing of group D was applied to group D; the dressing was prepared according to the usage steps and formula of Example 1, and after preparation, triethanolamine was used to adjust the pH value of the dressing to a neutral dressing of about 7.0, and this neutral dressing was applied to control group E; the blank control group was applied with a collagen fiber dressing soaked in sterile normal saline. After 30 days, based on the CIELAB color system, the ratio a of the chromaticity of the affected area of the subjects to the chromaticity of the skin adjacent to the affected area was calculated (the chromaticity of the affected area was the average chromaticity of 3 points of darker color in the affected area, and the chromaticity of the skin adjacent to the affected area was also the average chromaticity of 3 points of uniform color) to compare the pigment deposition of each group of people. The larger a was, the more serious the pigment deposition was; in addition, the feedback opinions of the subjects were collected, and the prognosis of scarring was investigated. The specific results are shown in Table 1.

[0052] Table 1 Pigment deposition of each group of people

[0053] Group Average value of chromaticity ratio a for each group Patient feedback on irritation Average scar height Test Group 1 1.14 Cool, slightly irritating 0.21 mm Test Group 2 1.21 Cool, slightly irritating 0.22 mm Test Group 3 1.15 Cool, slightly irritating 0.25 mm Control Group A 1.27 Cool, slightly irritating 0.35 mm Control Group B 1.34 Cool, slightly irritating 0.32 mm Control Group C 1.31 Cool, slightly irritating 0.25 mm Control Group D 1.36 Cool, slightly irritating 0.51 mm Control Group E 1.41 Cool, non-irritating 0.39 mm Blank Control Group 1.47 Cool, slightly irritating 0.64 mm

[0054] It can be easily seen from Table 1 that except for no obvious effect in control group E, the pigment deposition of each group of people was alleviated compared with that of the blank control group, but there were obvious differences in the effects. The experimental groups achieved excellent depigmentation effects, indicating that each component in the dressing of the present invention has an obvious compatibility effect on the depigmentation effect; control group D shows that tranexamic acid in the formula has an obvious scar prevention advantage, and control group E shows that the formula of the present invention has excellent depigmentation and scar removal effects only in a slightly acidic environment.

[0055] Comparative Example 2

[0056] In order to investigate the influence of separating the supplement bag from the dressing matrix bag on the depigmentation effect of the dressing, the following comparative experiment was set up:

[0057] Experimental group A: The dressing prepared in Example 1 was stored for 30 days and then used according to the usage method of Example 1.

[0058] Experimental group B: Grind 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut powder, 15 g of salvia miltiorrhiza powder, 5 g of angelica sinensis powder, 3 g of moutan cortex powder, and 2 g of vitamin C, and directly and evenly disperse them in 20 ml of sterilized physiological saline to obtain a medicinal slurry. Then add xanthan gum in the supplement bag to the system and stir until a gel state is formed. Use it immediately after preparation.

[0059] Experimental group C: Sterilely package the gel-state dressing prepared in experimental group B and use it after 30 days.

[0060] Effect evaluation test:

[0061] Personnel: Using the same personnel selection criteria as in Comparative Example 1, 30 people were selected.

[0062] The test process is as follows:

[0063] (1) Divide the subjects into 3 groups, with 10 people in each group;

[0064] (2) Apply the dressing to the subjects once every two days, applying the dressings described in experimental group A, experimental group B, and experimental group C respectively. After 30 days, based on the CIELAB color system, calculate the ratio a of the chromaticity of the affected area of the subject to the chromaticity of the skin adjacent to the affected area. The specific results are shown in Table 2.

[0065] Table 2 Pigment deposition of each group of personnel

[0066] Group Average value of chromaticity ratio a for each group Patient feedback on irritation Average scar height Experimental Group A 1.16 Cool, slightly irritating 0.22 mm Experimental Group B 1.15 Cool, slightly irritating 0.22 mm Experimental Group C 1.32 Cool, slightly irritating 0.23 mm

[0067] It can be easily seen from Table 2 that packaging vitamin C separately can ensure the stability of the dressing effect, while combined packaging may affect the depigmentation effect due to the instability of vitamin C in a neutral environment. However, in scar prevention, the effect change is not significant.

[0068] The above-described embodiments only represent the specific implementation manners of the present application. The description is relatively specific and detailed, but it should not be construed as a limitation on the protection scope of the present application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the technical solution of the present application, several deformations and improvements can still be made, and these all belong to the protection scope of the present application.

Claims

1. An anti-pigmentation drug dressing, characterized in that, It includes a dressing matrix medicine bag and a supplement bag. The dressing matrix medicine bag contains a dressing matrix medicine pulp. Calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1 - 2 g of tranexamic acid, 1 - 3 g of vitamin B3, 1 - 3 g of vitamin E, 8 - 12 g of Chinese gallnut, 12 - 16 g of Salvia miltiorrhiza, 4 - 8 g of Angelica sinensis, 4 - 5 g of Cortex Moutan, and 15 - 30 ml of sterile normal saline. The supplement bag contains 1 - 3 g of vitamin C and 8 - 12 g of xanthan gum.

2. The anti-pigmentation drug dressing according to claim 1, wherein Calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1.2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile normal saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

3. The anti-pigmentation drug dressing according to claim 1, characterized in that Calculated per portion of the dressing, the dressing matrix medicine pulp consists of 1 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile normal saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

4. The anti-pigmentation pharmaceutical dressing according to claim 1, wherein, Calculated per portion of the dressing, the dressing matrix medicine pulp consists of 2 g of tranexamic acid, 2 g of vitamin B3, 2 g of vitamin E, 10 g of Chinese gallnut, 15 g of Salvia miltiorrhiza, 5 g of Angelica sinensis, 3 g of Cortex Moutan, and 10 ml of sterile normal saline. The supplement bag contains 2 g of vitamin C and 10 g of xanthan gum.

5. The preparation method of an anti-pigmentation drug dressing according to any one of claims 1 to 4, characterized in that, It includes the following steps: (1) Uniformly disperse tranexamic acid, vitamin B3, vitamin E, the ground powder of Chinese gallnut, the ground powder of Salvia miltiorrhiza, the ground powder of Angelica sinensis, and the ground powder of Cortex Moutan in sterile normal saline to obtain a medicine pulp, and encapsulate the medicine liquid in a sterile environment to obtain a dressing matrix medicine bag; (2) Sterilely encapsulate vitamin C and xanthan gum separately and then encapsulate them into the same bag to obtain a supplement bag.

6. The method of using an anti-pigmentation drug dressing according to any one of claims 1 to 4, characterized in that, It includes the following steps: (1) Open the dressing matrix medicine bag, add vitamin C in the supplement bag, and then repeatedly squeeze and knead the dressing matrix medicine bag so that vitamin C and each component of the medicine pulp are uniformly dispersed; (2) Add xanthan gum in the supplement bag into the system, and repeatedly squeeze and knead the dressing matrix medicine bag until it forms a gel state, then it can be used as a dressing.