Liquid injection device and injection control method

Abstract

The invention relates to a liquid injection device and an injection control method. The multi-channel control valve and the first flow velocity sensors are arranged on the injection host and are electrically connected with the injection control device, and the injection control device obtains the target concentration of the mixed liquid medicine so as to determine the target proportion of each original liquid medicine. And the driving pump is started, so that the raw medicine liquid is mixed through the multi-channel control valve and then the mixed medicine liquid is output. Each first flow velocity sensor detects the current flow velocity of the original liquid medicine in the corresponding channel, and if it is evaluated that the current flow velocity ratio of each channel is not matched with the target proportion, the multi-channel control valve is controlled to adjust the opening degree of the corresponding channel till the current flow velocity ratio is consistent with the target proportion. According to the liquid injection device and the injection control method, the current flow speed of the original liquid medicine in each channel is collected in real time, and the concentration deviation of the mixed liquid medicine is reduced. And the injection control device controls the cooperative work of the driving pump and the multi-channel control valve to improve the liquid medicine mixing precision and enhance the contrast imaging effect.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and particularly to a liquid injection device and an injection control method. Background Art

[0002] In the medical field, during X-ray, nuclear magnetic resonance, and ultrasound diagnosis and treatment processes, the syringe system undertakes the important task of accurately injecting liquid medicine or contrast agent. Traditional syringe systems, such as the syringe and hose system disclosed in Patent CN1013371068, control the pumping of liquid medicine or contrast agent into the human body through a driving pump.

[0003] With the development of technology, some improvement solutions, such as Patent CN104689421B, propose a syringe and control method for injecting liquid, which detects the pressure of the liquid conveyed by the pump, measures the pressure integral by integrating the pressure change curve over time, and when the measured pressure integral exceeds a predetermined integral limit value, shuts down the pump or operates the pump at a reduced power to avoid dangerous pressure in the injection system. The driving pump type high-pressure syringe and its flow rate adjustment method disclosed in Patent CN117919548A, the control module can adjust according to the conveyed pressure value to control the speed of conveying the liquid medicine, so that the speed of the injection module conveying the liquid medicine is reduced or increased. Patent CN115300708A records an automatic contrast injection instrument injection speed adaptive adjustment device and adjustment method, which realizes the matching of the injection rate and the injection pressure, ensures the completion of the total injection volume, and controls and adjusts the injection rate when the injection pressure is abnormal, thereby ensuring the injection effect.

[0004] Currently, the above-mentioned existing technical solutions mainly focus on the influence of injection pressure on the injection process or flow rate, ignoring an important requirement in clinical applications. In actual clinical operations, it is often necessary to use contrast agents with different concentrations, and the factory concentration of the contrast agent is usually a standard value, which requires mixing normal saline and the contrast agent to achieve different concentration imaging effects. However, most traditional solutions rely on power on / off to control the liquid intake of the syringe, and this control method lacks flexibility and is difficult to meet the needs of diverse mixing ratios in clinical practice. Summary of the Invention

[0005] Based on this, it is necessary to provide a liquid injection device, an injection control method, and an injection control device that are convenient for more accurate control of liquid medicines with different concentrations in view of the above problems.

[0006] A liquid injection device, which includes an injection main body, a driving pump, a multi-way control valve, a first flow rate sensor, and an injection control device. The driving pump is arranged on the injection main body and is used to provide power for the delivery of the liquid medicine. The multi-way control valve is arranged on the injection main body and is located in front of the pumping of the driving pump. The multi-way control valve is used to control the opening degree of the output passages of each liquid medicine. The first flow rate sensor is arranged on the injection main body, and the number of the first flow rate sensors is at least two. Each first flow rate sensor is used to detect the current output flow rate of the corresponding liquid medicine. The multi-way control valve and each of the first flow rate sensors are electrically connected to the injection control device. The injection control device is used to control the multi-way control valve to adjust the opening degree of each channel according to the target proportion of each original liquid medicine under the target concentration, so that the ratio of the current flow rates detected by each first flow rate sensor matches the target proportion.

[0007] In one embodiment, the liquid injection device further includes a second flow rate sensor, which is arranged behind the pumping of the driving pump. The second flow rate sensor is used to detect the current flow rate of the liquid medicine pumped by the driving pump. The injection control device is used to control the operation of the injection control device and / or the driving pump according to the detection data of the second flow rate sensor.

[0008] In one embodiment, the liquid injection device further includes a temperature compensator, which is arranged in front of the pumping of the driving pump. The temperature compensator is electrically connected to the injection control device and is controlled to heat the liquid medicine entering the driving pump.

[0009] In one embodiment, the multi-way control valve is a four-way servo proportional valve; and / or

[0010] The liquid injection device further includes a pressure collector, which is arranged behind the pumping of the driving pump and is used to facilitate the collection of the pipeline pressure during the infusion process; and / or

[0011] The liquid injection device further includes an ultrasonic bubble sensor, which is used to detect the bubble condition in the infusion pipeline.

[0012] An injection control method, which includes:

[0013] Obtain the target concentration of the mixed liquid medicine, and obtain the target proportion of each original liquid medicine according to the target concentration;

[0014] Control the multi-way control valve to open, and obtain the current flow rates of the original liquid medicines in each channel;

[0015] Determine whether the current flow rate ratio of the original liquid medicine in each channel matches the target ratio;

[0016] If not, control the multi-path control valve to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target ratio.

[0017] In one embodiment, controlling the multi-path control valve to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target ratio includes:

[0018] Control the multi-path control valve to increase the opening degree of the channel with a large proportion of the original liquid medicine, and / or reduce the opening degree of the channel with a small proportion of the original liquid medicine until the current flow rate ratio is consistent with the target ratio.

[0019] In one embodiment, the injection control method further includes:

[0020] Obtain the initial temperature of the original liquid medicine and the current ambient temperature, and evaluate the current viscosity of the mixed liquid medicine according to the current infusion duration, the current ambient temperature, the initial temperature, and the target concentration;

[0021] Obtain the current output flow rate of the mixed liquid medicine, and determine whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold;

[0022] If so, obtain the target opening degree corresponding to the multi-path control valve according to the target flow rate and the current viscosity of the mixed liquid medicine;

[0023] Adjust the current opening degree of each path of the multi-path control valve to the target opening degree.

[0024] In one embodiment, after determining whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold, it further includes:

[0025] If it is determined that the deviation between the current output flow rate and the target flow rate is less than the preset threshold, or the opening degree of any one path in the multi-path control valve reaches the maximum adjustment value, obtain the target rotation speed corresponding to the driving pump according to the target flow rate, the current viscosity of the mixed liquid medicine, and the current opening degree of the multi-path control valve;

[0026] Adjust the current rotation speed of the driving pump to the target rotation speed.

[0027] In one embodiment, adjusting the current rotation speed of the driving pump to the target rotation speed includes:

[0028] Calculate the adjusted pipeline pressure according to the target rotation speed and the current viscosity of the mixed liquid medicine;

[0029] If the calculated pipeline pressure is less than the preset maximum pressure, adjust the current speed of the drive pump to the target speed;

[0030] If the calculated pipeline pressure is greater than or equal to the preset maximum pressure, do not adjust the current speed of the drive pump to the target speed.

[0031] In one embodiment, the injection control method further includes:

[0032] Obtain the current pressure value of the pipeline;

[0033] If the current pressure value is greater than or equal to the preset maximum pressure, trigger controlling the drive pump to reduce speed and / or controlling the multi-way control valve to reduce the current opening degree;

[0034] Judge whether the current viscosity of the mixed liquid medicine is greater than the preset viscosity;

[0035] If so, control the temperature compensator to start heating the liquid medicine until the current temperature of the liquid medicine reaches the preset temperature.

[0036] In the above liquid injection device and injection control method, the original liquid medicine is set on the injection main machine, the multi-way control valve and each first flow rate sensor are electrically connected to the injection control device. The injection control device obtains the target concentration of the mixed liquid medicine and determines the target proportion of each original liquid medicine according to the target concentration. The multi-way control valve opens and adjusts the opening degrees of the channels of each original liquid medicine according to the target proportion of each original liquid medicine determined by the target concentration. Start the drive pump so that after each original liquid medicine is mixed through the multi-way control valve, it is pumped out by the drive pump as the mixed liquid medicine. Each channel detects the current flow rate of the original liquid medicine in this channel through a first flow rate sensor, and evaluates whether the ratio of the current flow rates detected by the first flow rate sensors of each channel matches the target proportion. If not, control the multi-way control valve to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion. In the above liquid injection device and injection control method, each channel is configured with a flow rate sensor to collect the current flow rate of the original liquid medicine in each channel in real time and perform dynamic comparison with the target proportion. The real-time calibration ability can significantly reduce the concentration deviation of the mixed liquid medicine, meet the clinical requirements for high-precision liquid medicine concentration, avoid the concentration error that may be caused by traditional fixed-ratio mixing, and is applicable to scenarios of various concentration liquid medicine ratios. Even in the face of disturbances such as pipeline resistance changes and pump speed fluctuations, the target proportion can be maintained through feedback adjustment to ensure the stability of the concentration of the mixed liquid medicine. And the injection control device controls the coordinated operation of the drive pump and the multi-way control valve to improve the full-process automation and the operation efficiency. Description of the Drawings

[0037] The accompanying drawings, which form a part of this application, are used to provide a further understanding of this application. The schematic embodiments and descriptions thereof of this application are used to explain this application and do not constitute an improper limitation to this application.

[0038] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of this application. For those of ordinary skill in the art, other accompanying drawings can be obtained based on these drawings without creative efforts.

[0039] In addition, the accompanying drawings are not drawn to a scale of 1:1, and the relative sizes of the respective elements are only schematically drawn in the accompanying drawings and not necessarily drawn to the actual scale.

[0040] Figure 1 It is a structural block diagram of a liquid injection device in an embodiment.

[0041] Figure 2 It is Figure 1 a schematic structural diagram of the liquid injection device shown.

[0042] Figure 3 It is Figure 1 a schematic structural diagram of the multi-way control valve in

[0043] Figure 4 It is Figure 3 a sectional view of the multi-way control valve shown.

[0044] Figure 5 It is Figure 3 a schematic structural diagram of the control valve unit in

[0045] Figure 6 It is Figure 5 a schematic structural diagram of a control valve unit in

[0046] Figure 7 It is a flowchart of an injection control method in an embodiment.

[0047] Figure 8 It is a flowchart of a method for regulating the concentration of a mixed liquid medicine in an embodiment.

[0048] Figure 9 It is a flowchart of an injection control method in another embodiment.

[0049] Explanation of reference numerals:

[0050] Liquid injection device 10; injection main body 110; pipeline arrangement groove 112; driving pump 120; multi-channel control valve 130; guide member 131; guide hole 1312; limit hole 214; control valve unit 132; driving member 133; pushing member 134; linkage member 135; first linkage portion 1351; second linkage portion 1352; rotating portion 1353; first flow rate sensor 140; ultrasonic bubble sensor 150; pressure collector 160; particle filter 170. Detailed implementation manners

[0051] To make the above objects, features, and advantages of the present application more obvious and understandable, the following will describe the detailed implementation manners of the present application with reference to the accompanying drawings. Many specific details are set forth in the following description to fully understand the present application. However, the present application can be implemented in many other ways different from those described herein. Those skilled in the art can make similar improvements without departing from the connotation of the present application. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0052] Refer to Figure 1 and Figure 2 In a liquid injection device 10 according to an embodiment of the present application, it includes an injection main body 110, a driving pump 120, a multi-channel control valve 130, a first flow rate sensor 140, and an injection control device. The driving pump 120 is arranged on the injection main body 110, and the driving pump 120 is used to provide power for the delivery of the liquid medicine. The multi-channel control valve 130 is arranged on the injection main body 110. The multi-channel control valve 130 is located in front of the pumping of the driving pump 120. The multi-channel control valve 130 is used to control the opening degree of the output passages of each liquid medicine. The first flow rate sensor 140 is arranged on the injection main body 110, and the number of the first flow rate sensors 140 is at least two. Each first flow rate sensor 140 is used to detect the current output flow rate of the corresponding liquid medicine. The multi-channel control valve 130 and each first flow rate sensor 140 are electrically connected to the injection control device. The injection control device is used to control the multi-channel control valve 130 to adjust the opening degree of each channel according to the target proportion of each original liquid medicine at the target concentration, so that the current flow rate ratio detected by each first flow rate sensor 140 matches the target proportion.

[0053] During use, the original liquid medicine is set on the injection main body 110. The multi-channel control valve 130 and each first flow rate sensor 140 are electrically connected to the injection control device. The injection control device obtains the target concentration of the mixed liquid medicine and determines the target proportion of each original liquid medicine according to the target concentration. The multi-channel control valve 130 opens and adjusts the opening degree of each original liquid medicine channel according to the target proportion of each original liquid medicine determined by the target concentration. The driving pump 120 is started so that after each original liquid medicine is mixed through the multi-channel control valve 130, the driving pump 120 pumps and outputs the mixed liquid medicine. The current flow rate of the original liquid medicine in each channel is detected by a first flow rate sensor 140 in each channel, and it is evaluated whether the ratio of the current flow rates detected by the first flow rate sensors 140 in each channel matches the target proportion. If not, the multi-channel control valve 130 is controlled to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion.

[0054] In one embodiment, the liquid injection device 10 further includes a second flow rate sensor. The second flow rate sensor is arranged behind the pumping of the driving pump 120. The second flow rate sensor is used to detect the current flow rate of the liquid medicine pumped by the driving pump 120, and the injection control device is used to control the operation of the injection control device and / or the driving pump 120 according to the detection data of the second flow rate sensor. By arranging the second flow rate sensor, it is convenient to monitor the flow rate of the mixed liquid medicine in real time, that is, the flow rate of the liquid medicine entering the patient's body, so as to ensure that the flow rate is relatively constant.

[0055] In one embodiment, the liquid injection device 10 further includes an ultrasonic bubble sensor 150. The ultrasonic bubble sensor 150 can be used to detect whether there are bubbles in the infusion pipeline to ensure the safety during the infusion process. Specifically, the number of ultrasonic bubble sensors 150 is multiple. An ultrasonic bubble sensor 150 is arranged at the liquid medicine output port, and this ultrasonic bubble sensor 150 is used to detect whether there is liquid medicine output. Specifically, an ultrasonic bubble sensor 150 is arranged at the output end of the driving pump 120, and this ultrasonic bubble sensor 150 is used to detect whether there are bubbles in the liquid medicine after passing through the driving pump 120. Specifically, an ultrasonic bubble sensor 150 is arranged before entering the patient pipeline, and this ultrasonic bubble sensor 150 is used to finally confirm whether there are bubbles in the liquid medicine input into the patient. By arranging ultrasonic bubble sensors 150 at multiple positions respectively, the bubble conditions can be detected at multiple positions in the pipeline through which the liquid medicine flows, ensuring the safety during the infusion process.

[0056] In one embodiment, the liquid injection device 10 further includes a pressure collector 160. By providing the pressure collector 160, it is convenient to collect the pipeline pressure during the infusion process to avoid excessive infusion pressure and cause discomfort to the patient. Specifically, the pressure collector 160 is arranged behind the pumping of the driving pump 120. In this embodiment, the pressure collector 160 is arranged between the driving pump 120 and the ultrasonic bubble sensor 150 close to the driving pump 120. Or it can also be arranged between two ultrasonic bubble sensors 150 behind the driving pump 120. In this embodiment, the pressure collector 160 can be directly formed on the infusion pipeline. Of course, it can also be arranged on the injection mainframe 110.

[0057] In one embodiment, the liquid injection device 10 further includes a particle filter 170. The particle filter 170 is used to filter and separate particles in the liquid medicine. In this embodiment, the particle filter 170 can be directly formed on the infusion pipeline.

[0058] In one embodiment, the liquid injection device 10 further includes a temperature compensator. The temperature compensator is arranged in front of the pumping of the driving pump 120. The temperature compensator is electrically connected to the injection control device. The temperature compensator is controlled to heat the liquid medicine entering the driving pump 120. By providing the temperature compensator, it is convenient to heat the liquid medicine in a low-temperature environment, increase the viscosity of the liquid medicine, and reduce the possibility of the infusion pressure exceeding the standard or the infusion flow rate not meeting the standard due to the large viscosity of the liquid medicine.

[0059] Specifically, the temperature compensator includes a first heater. A pipeline layout groove 112 is provided on the injection mainframe 110. The first heater is arranged in the pipeline layout groove 112. The pipeline layout groove 112 is for arranging the infusion pipeline. By the first heater, the pipeline located in the pipeline layout groove 112 can be heated, and then the liquid medicine in the pipeline can be heated. Specifically, the pipeline layout groove 112 is arranged at the front end of the multi-way control valve 130. In other embodiments, the first heater can also be arranged at other positions in front of the driving pump.

[0060] Furthermore, the temperature compensator further includes a second heater. A medicine placement rack is provided on the injection mainframe 110 for placing medicines. The second heater is arranged on the medicine placement rack for heating or keeping the temperature of the medicines located on the medicine placement rack.

[0061] Refer to Figures 3 to 6, In one embodiment, the multi-path control valve 130 includes a guide member 131 and a control valve unit 132. A guide hole 1312 is formed in the guide member 131. The control valve unit 132 is located on one side of the guide member 131. The control valve unit 132 includes a driving member 133, a pushing member 134, and a linkage member 135. The pushing member 134 is inserted into the guide hole 1312 and can move within the guide hole 1312. The linkage member 135 is rotatably mounted on the guide member 131. One of the driving member 133 and the pushing member 134 is slidably connected to the linkage member 135 and can rotate relative to the linkage member 135, and the other is rotatably connected to the linkage member 135. The distance between the pushing member 134 and the linkage member 135 at the connection position on the guide member 131 is smaller than the distance between the driving member 133 and the linkage member 135 at the connection position on the guide member 131. The driving member 133 is controlled to push the linkage member 135 to swing, so as to drive the pushing member 134 to move within the guide hole 1312. In this embodiment, the control valve unit 132 is disposed on the injection mainframe 110, and the guide member 131 is aligned with the pipeline arrangement groove 112, so that the guide hole 1312 is relatively communicated with the pipeline arrangement groove 112, and the pushing member 134 can extend from the guide hole 1312 into the pipeline arrangement groove 112.

[0062] During use, the infusion pipeline is arranged in the pipeline arrangement groove 112. The driving member 133 drives the pushing member 134 to move within the guide hole 1312 through the linkage member 135. By using the method of the pushing member 134 extending out of the guide hole 1312 to squeeze the infusion pipeline, the liquid medicine flow area is controlled, and the liquid medicine flow rate or concentration ratio can be flexibly adjusted to meet the diverse fluid control requirements during the diagnosis and treatment process. Since the distance between the pushing member 134 and the linkage member 135 at the connection position on the guide member 131 is smaller than the distance between the driving member 133 and the linkage member 135 at the connection position on the guide member 131, when the driving member 133 drives the linkage member 135 to move a large stroke, the pushing member 134 only generates a small displacement. The precise control of the moving distance of the pushing member 134 can be realized by reducing the driving range, so as to realize the precise squeezing of the infusion pipeline. The above multi-path control valve 130 converts the "large stroke input" of the driving member 133 into the "small stroke output" of the pushing member 134 through the lever structure design of the linkage member 135. With the linear guiding function of the guide member 131, the precise control of the squeezing degree of the infusion pipeline can be realized within a small range, effectively improving the control precision of the liquid medicine flow rate or concentration ratio, and ensuring the safety and effectiveness of the diagnosis and treatment process. At the same time, the layout design of the linkage member 135 enables the installation position of the pushing member 134 to be flexibly corresponding to different positions of the pipeline arrangement groove 112, with strong compatibility.

[0063] In this embodiment, the linkage member 135 is in a rod shape. One end of the linkage member 135 is a rotating portion 1353, and the other end is a first linkage portion 1351. The portion between the two ends is formed as a second linkage portion 1352. The rotating portion 1353 is rotatably mounted on the guiding member 131. One end of the pushing member 134 is inserted into the guiding hole 1312, and the other end is rotatably connected to the second linkage portion 1352. The driving member 133 is rotatably connected to the first linkage portion 1351 and can slide on the first linkage portion 1351.

[0064] In this embodiment, the driving member 133 can be a linear motor. In other embodiments, the driving member 133 can also be other mechanisms such as an electromagnet or a hydraulic rod that can drive the linkage member 135 to swing.

[0065] In one embodiment, the number of the control valve units 132 is at least two. The guiding member 131 is provided with guiding holes 1312 that are the same in number as the control valve units 132. One pushing member 134 of each control valve unit 132 is correspondingly inserted into one guiding hole 1312. By providing at least two control valve units 132, it is convenient to synchronously control at least two infusion pipelines, so as to realize the mixing of the liquid medicines in at least two infusion pipelines according to a set ratio and achieve the proportioning of liquid medicines with different concentrations.

[0066] In this embodiment, the number of the control valve units 132 is three. The guiding member 131 is provided with three guiding holes 1312 that are arranged at intervals. One pushing member 134 of each control valve unit 132 is correspondingly inserted into one guiding hole 1312, and the synchronous control of the liquid medicines in three infusion pipelines can be realized. Specifically, two of the control valve units 132 are arranged opposite to each other in parallel, and the linkage member 135 of the other control valve unit 132 is located between the linkage members 135 of these two control valve units 132, so that the pushing members 134 of the three control valve units 132 are arranged close to each other. By arranging the three linkage members 135 and arranging the driving member 133 and the pushing member 134 in a triangular shape, the structural arrangement of the multi-path control valve 130 is more compact, reducing the occupation of the space of the injection mainframe 110.

[0067] In this embodiment, the driving pump 120 is a peristaltic pump.

[0068] In this application, the terms "first" and "second" appear. These terms are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" can explicitly or implicitly include at least one such feature. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0069] In this application, unless otherwise clearly specified and defined, if terms such as "installed", "connected", "linked", "fixed", etc. appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0070] Referring to Figure 7 and Figure 8 , in one embodiment, the injection control method provided in this application can be applied to a liquid injection device 10 as shown in Figure 1 and 2 . Specifically, an injection control method is provided, including the following steps:

[0071] Step S110, obtaining the target concentration of the mixed medicinal liquid, and obtaining the target proportion of each original medicinal liquid according to the target concentration.

[0072] Specifically, set the target flow rate V of the mixed medicinal liquid set and the preset maximum pressure P max . The target flow rate and the preset maximum pressure can be determined according to the patient's condition or the condition of the medicinal liquid used. Obtain the initial temperature T0 of the original medicinal liquid and the target concentration C of the mixed medicinal liquid. Obtain the initial viscosity μ0 of the mixed medicinal liquid according to the obtained initial temperature T0 and target concentration C. Solve the initial opening A0 of the multi-channel control valve 130 and the initial rotation speed S0 of the driving pump 120 based on the target flow rate V set and μ0, while ensuring that the initial pressure P0 < P max . In this embodiment, the initial opening of this multi-channel control valve 130 can be the combined opening of each channel. Allocate the opening proportion of each channel according to the target proportion of each original medicinal liquid, so that the sum of the initial opening sizes of each channel is consistent with the initial opening A0 of the multi-channel control valve 130.

[0073] Step S120, controlling the multi-channel control valve 130 to open, and obtaining the current flow rate of the original medicinal liquid in each channel. Specifically, a first flow rate sensor 140 is arranged between the installation position of the original medicinal liquid and the multi-channel control valve 130 to detect the liquid outlet flow rate of each original medicinal liquid.

[0074] Step S130, determining whether the current flow rate ratio of the original medicinal liquid in each channel matches the target proportion;

[0075] Step S140, if not, then control the multi-channel control valve 130 to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target ratio.

[0076] Specifically, control the multi-channel control valve 130 to increase the opening degree of the channel with a large proportion of the original liquid medicine, and / or decrease the opening degree of the channel with a small proportion of the original liquid medicine until the current flow rate ratio is consistent with the target ratio. In this embodiment, as Figure 8 shown, taking the mixing of two original liquid medicines as an example, when the flow rate ratio detected by channels A and B is greater than the target ratio, increase the opening degree of channel B to increase the flow rate of channel B. At this time, the opening degree of channel A can remain unchanged. When the opening degree of channel B has been increased to the maximum adjustment value, then decrease the opening degree of channel A. Similarly, when the flow rate ratio detected by channels A and B is less than the target ratio, increase the opening degree of channel A. In this embodiment, during adjustment, only increase the opening degree of one of the channels, which is convenient for evaluating the adjusted flow rate ratio and at the same time for ensuring the flow rate of the driving pump 120 pumping the mixed liquid medicine. In other embodiments, when the flow rate ratio detected by channels A and B is greater than the target ratio, the opening degree of channel A can also be synchronously decreased while increasing the opening degree of channel B.

[0077] Refer to Figure 9 together. In one embodiment, the injection control method further includes:

[0078] Step S210, obtain the initial temperature T0 of the original liquid medicine and the current ambient temperature Ta, and evaluate the current viscosity μ of the mixed liquid medicine according to the current infusion duration t, the current ambient temperature Ta, and the initial temperature T0;

[0079] Specifically, according to the current infusion duration t, the current ambient temperature Ta, and the initial temperature T0, calculate the current temperature T(t) of the mixed liquid medicine as: T(t) = T a +(T0 - T a )e -kt ; where T(t) is the current temperature (°C) of the mixed liquid medicine, which decreases with time t and approaches the ambient temperature Ta; k is the heat loss coefficient, which is determined by the heat preservation performance of the liquid medicine delivery pipeline, the ambient convection intensity, etc. (unit: s-1).

[0080] In other embodiments, the current temperature of the mixed liquid medicine can also be obtained in real time through a temperature sensor. For example, the temperature of the mixed liquid medicine in front of the driving pump 120 and behind the multi-channel control valve 130 can be obtained.

[0081] Specifically, evaluate the current viscosity μ of the mixed liquid medicine according to the current temperature T(t) of the mixed liquid medicine and the target concentration C. The viscosity of the liquid medicine is positively correlated with the concentration, and the viscosity and temperature are in a negative exponential relationship. Further, the current viscosity μ is: Where: μ0 is the reference viscosity (Pa·s) of the low-concentration liquid medicine at the reference temperature T0; a is the temperature sensitivity coefficient (related to the type of liquid medicine, a>0 indicates that the viscosity increases as the temperature decreases); b is the concentration sensitivity coefficient (b>0 indicates that the viscosity increases as the concentration increases). In this embodiment, the reference temperature T0 is the initial concentration of the original liquid medicine, usually 37°C.

[0082] In another embodiment, the current viscosity μ of the mixed liquid medicine can also be obtained through experiments. According to the experimental corresponding relationship table of the liquid medicine viscosity μ with the current temperature T and concentration C of the liquid medicine, the current viscosity μ can be obtained by searching.

[0083] Step S220, obtain the current output flow rate of the mixed liquid medicine, and determine whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold. Specifically, the second flow rate sensor continuously detects the current output flow rate V of the mixed liquid medicine real , calculate the deviation from the target flow rate: ΔV = V set -V real . In this embodiment, the liquid medicine injection system is used for contrast agent injection. In order to ensure the contrast effect, it is necessary to ensure a constant injection flow rate. If the injection flow rate is too fast, it will cause discomfort to the patient. If the injection flow rate is slow, it will affect the contrast effect.

[0084] Step S230, if so, obtain the target opening degree corresponding to the multi-path control valve 130 according to the target flow rate and the current viscosity of the mixed liquid medicine.

[0085] Specifically, when the deviation |ΔV|>δ1, the opening degree of the multi-path control valve 130 is preferentially adjusted. By increasing the opening degree of the multi-path control valve 130, the cross-sectional area of the pipeline is enlarged, the flow resistance is reduced, the flow rate is increased, the energy consumption of the driving pump 120 is reduced, and the purpose of roughly adjusting the flow rate is achieved. The multi-path control valve 130 can quickly expand the flow channel under low load, and the driving pump 120 does not intervene temporarily, which can reduce the adjustment complexity.

[0086] Further, the target opening degree corresponding to the multi-path control valve 130 can be calculated according to the formula: Calculated; where k V is the system structure constant (related to the pipe diameter, pipeline length, and characteristics of the driving pump 120), at this time V is the target flow rate V set , and S is the initial rotation speed S0 of the driving pump 120.

[0087] Step S240: Adjust the current opening degree of each passage of the multi-pass control valve 130 to the target opening degree. It should be noted that the maximum opening degree of each passage cannot exceed the maximum adjustment value. In this embodiment, the maximum adjustment value is less than the maximum opening degree. For example, the maximum adjustment value can be 90% of the maximum opening degree, to avoid pressure loss or turbulence caused by the full opening of the multi-pass control valve 130, and at the same time, not to open the passage opening degree to the maximum, leaving an adjustment space for subsequent adjustment. It should be noted that the multi-pass control valve 130 controls the opening degrees of multiple passages. Here, increasing the opening degree requires increasing the opening degrees of each passage simultaneously. The sum of the opening degrees of each passage is A, and the flow velocity ratio of each passage remains unchanged.

[0088] In another embodiment, increase the opening degree of the multi-pass control valve 130 by a preset step ΔA, so that the opening degree of the multi-pass control valve 130 increases from A0 to A. In other embodiments, the opening degree of the multi-pass control valve 130 can also be adjusted by using PID control.

[0089] In one embodiment, in step S220, it is judged whether the deviation between the current output flow velocity and the target flow velocity is greater than or equal to a preset threshold. After that, it further includes:

[0090] Step S250: If it is judged that the deviation between the current output flow velocity and the target flow velocity is less than the preset threshold, or the opening degree of any one passage in the multi-pass control valve 130 reaches the maximum adjustment value, then according to the target flow velocity V set 、the current viscosity μ of the mixed liquid medicine and the current opening degree A of the multi-pass control valve 130, obtain the target rotation speed S corresponding to the driving pump 120. When the opening degree of one passage of the multi-pass control valve 130 reaches the maximum adjustment value, the pump intervenes, and the linear characteristic of the driving pump 120 is used to accurately compensate and adjust the output flow velocity of the liquid medicine. The multi-pass control valve 130 is used as an auxiliary fine adjustment, and when necessary, the opening degree is reduced to cooperate with the pump. Or, when the deviation between the current output flow velocity and the target flow velocity is less than the preset threshold, by adjusting the rotation speed of the driving pump 120, the purpose of supplementary adjustment and fine adjustment is achieved.

[0091] Specifically, according to the current viscosity μ, the current opening degree A of the multi-pass control valve 130 and the target flow velocity V set Through Calculate the target rotation speed S required for the current driving pump 120.

[0092] Step S260: Adjust the current rotation speed of the driving pump 120 to the target rotation speed.

[0093] Specifically, in step S261, according to V set 、the current viscosity μ of the mixed liquid medicine, calculate the adjusted pipeline pressure.

[0094] Furthermore, the pipeline pressure model is: P = P0 + k p·μ·S; where P0 is the initial pipeline pressure before the rotational speed of the driving pump 120 is adjusted, that is, the initial pipeline pressure when the rotational speed of the driving pump 120 is S0, and k p is the pressure coefficient.

[0095] Step S262, if the calculated pipeline pressure P is less than the preset maximum pressure P max , then adjust the current rotational speed S0 of the driving pump 120 to the target rotational speed S.

[0096] Furthermore, a pressure PID controller is used to dynamically adjust the rotational speed, with real-time feedback and PID compensation. Among them, the required rotational speed S of the driving pump 120 is: In this embodiment, S base is S0; e p =P max -P real is the pressure deviation, that is, the difference between the current pressure P real and the preset maximum pressure P max ; the PID parameter K p is the proportional adjustment parameter, which responds quickly according to the pressure deviation and adjusts the pump speed; K i is the integral adjustment parameter, which eliminates long-term static errors, such as the flow attenuation caused by the deformation of the hose; K d is the differential adjustment parameter, which suppresses the instantaneous fluctuations caused by temperature mutations or concentration fluctuations.

[0097] In this embodiment, through real-time pressure feedback, it is ensured that P real does not exceed P max when the rotational speed of the driving pump 120 is adjusted, avoiding pipeline bursting or patient injury. The PID algorithm is used to suppress pressure fluctuations and achieve stable control.

[0098] Step S263, if the calculated pipeline pressure is greater than or equal to the preset maximum pressure, then do not execute the adjustment of the current rotational speed of the driving pump 120 to the target rotational speed. Even if the current flow rate of the mixed liquid medicine does not meet the standard, do not execute the increase of the rotational speed of the driving pump 120, or the rotational speed of the driving pump 120 can be reduced and an alarm can be given.

[0099] In one embodiment, the injection control method further includes:

[0100] Obtain the current pressure value P real of the pipeline. The current pressure value P real of the pipeline can be detected throughout the adjustment and control process to ensure the safety of the liquid medicine delivery.

[0101] If the current pressure value P real is greater than or equal to the preset maximum pressure P maxWhen this occurs, control is triggered to drive the pump 120 to reduce its speed and / or control the multi-way control valve 130 to reduce its current opening degree. For safety considerations, when the pressure exceeds the limit, pressure reduction needs to be controlled. Thus, by reducing the rotational speed of the drive pump 120 and / or reducing the current opening degree of the multi-way control valve 130, the liquid medicine delivery is switched to the low flow rate mode.

[0102] In one embodiment, it is determined whether the current viscosity of the mixed liquid medicine is greater than a preset viscosity. Through viscosity evaluation, it is judged whether the pressure exceeds the limit due to an abnormal increase in the viscosity of the liquid medicine rather than the failure of the control algorithm. In this embodiment, viscosity can be used as the core parameter for pressure prediction and evaluation to prevent the risk of overpressure caused by a sudden increase in viscosity (such as a sudden drop in temperature).

[0103] Specifically, if the current viscosity of the mixed liquid medicine is greater than the preset viscosity, the temperature compensator is controlled to start heating the liquid medicine until the current temperature of the liquid medicine reaches the preset temperature. By heating the liquid medicine, the temperature of the liquid medicine is increased to achieve the purpose of reducing the viscosity of the liquid medicine. In other embodiments, the drive pump 120 can be controlled to reduce its speed and / or the multi-way control valve 130 can be controlled to reduce its current opening degree to ensure that the pipeline pressure P real does not exceed the preset maximum pressure P max .

[0104] In one embodiment, when the output temperature of the mixed liquid medicine is less than the preset temperature, for example, less than 30 °C, the temperature compensator is enabled to heat the liquid medicine so that the output temperature of the mixed liquid medicine is maintained at 37 ± 2 °C.

[0105] In one embodiment, the pressure of the pipeline is monitored in real time. When a sudden change in the pipeline pressure is detected, it is determined that there is a pipeline leak, and the injection is immediately stopped and an alarm is given.

[0106] In one embodiment, the adjustment process of each injection can be recorded for predicting the best parameter combination in similar scenarios.

[0107] For the above injection control method, a flow rate sensor is configured for each channel to collect the current flow rate of the original liquid medicine in each channel in real time and perform dynamic comparison with the target ratio. The real-time calibration ability can significantly reduce the concentration deviation of the mixed liquid medicine, meet the clinical requirements for high-precision liquid medicine concentration, avoid the concentration error that may be caused by traditional fixed-ratio mixing, and is applicable to scenarios of various concentration liquid medicine ratios. Even in the face of interferences such as pipeline resistance changes and pump speed fluctuations, the target ratio can be maintained through feedback adjustment to ensure the stability of the concentration of the mixed liquid medicine. Moreover, the injection control device controls the coordinated operation of the drive pump 120 and the multi-way control valve 130 to improve the full-process automation, improve the operation efficiency, improve the liquid medicine mixing accuracy during the double-flow injection of the peristaltic pump, and enhance the contrast imaging effect.

[0108] The above injection control method realizes hierarchical control. First, the opening degree of the multi-path control valve 130 is roughly adjusted to control the flow rate, which has little impact on the pipeline pressure and mainly affects the pipeline resistance. Then, in combination with pressure feedback, the rotational speed of the driving pump 120 is dynamically corrected and adjusted to achieve fine adjustment of the liquid medicine output flow rate, avoiding overpressure. Finally, under the condition of changing liquid medicine viscosity, the stability of the liquid medicine output flow rate is ensured. At the same time, the rapid rough adjustment of the multi-path control valve 130 can reduce the high-load operation time of the driving pump 120. The linear adjustment of the driving pump 120 compensates for the non-linear error of the multi-path control valve 130. Combined with viscosity compensation, it adapts to different liquid medicine characteristics and the characteristics of the liquid medicine under different viscosities.

[0109] It should be understood that although Figures 7 - 9 the steps in the flowchart of Figures 7 - 9 are shown in sequence according to the indication of the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise clearly stated in this article, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover,

[0110] In one embodiment, the injection control device includes:

[0111] a concentration determination module, which is used to obtain the target concentration of the mixed liquid medicine and obtain the target proportion of each original liquid medicine according to the target concentration;

[0112] a flow rate acquisition module, which is used to acquire the current flow rate of each channel of the original liquid medicine;

[0113] a judgment module, which is used to judge whether the current flow rate ratio of each channel of the original liquid medicine matches the target proportion;

[0114] an opening degree control module, which is used to control the multi-path control valve 130 to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion.

[0115] For the specific limitations of the injection control device, reference can be made to the limitations of the injection control method in the above text, which will not be elaborated here. Each module in the above injection control device can be implemented in whole or in part by software, hardware, and their combination. The above modules can be embedded in the processor of the computer device in hardware form or independent of it, or stored in the memory of the computer device in software form, so that the processor can call and execute the operations corresponding to the above modules.

[0116] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of concise description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0117] The above-described embodiments only represent several implementation manners of the present application. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several modifications and improvements can still be made, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the appended claims.

Claims

1. A liquid injection device, characterized in that, The liquid injection device includes: An injection main body; A driving pump, which is arranged on the injection main body and is used to provide power for the delivery of the liquid medicine; A multi-way control valve, which is arranged on the injection main body and is located in front of the pumping of the driving pump, and the multi-way control valve is used to control the opening degree of the output passages of each liquid medicine; A first flow rate sensor, which is arranged on the injection main body and the number of the first flow rate sensors is at least two, and each first flow rate sensor is used to detect the current output flow rate of the corresponding liquid medicine; and An injection control device, the multi-way control valve and each of the first flow rate sensors are electrically connected to the injection control device, and the injection control device is used to control the multi-way control valve to adjust the opening degree of each channel according to the target proportion of each original liquid medicine at the target concentration, so that the current flow rate ratio detected by each first flow rate sensor matches the target proportion.

2. The liquid injection device according to claim 1, wherein The liquid injection device further includes a second flow rate sensor, which is arranged behind the pumping of the driving pump; the second flow rate sensor is used to detect the current flow rate of the liquid medicine pumped by the driving pump, and the injection control device is used to control the operation of the injection control device and / or the driving pump according to the detection data of the second flow rate sensor.

3. The liquid injection device according to claim 1, characterized in that, The liquid injection device further includes a temperature compensator, which is arranged in front of the pumping of the driving pump, and the temperature compensator is electrically connected to the injection control device, and the temperature compensator is controlled to heat the liquid medicine entering the driving pump.

4. The liquid injection device according to any one of claims 1 to 3, characterized in that The multi-way control valve is a four-way servo proportional valve; and / or The liquid injection device further includes a pressure collector, which is arranged behind the pumping of the driving pump, and the pressure collector is used to facilitate the collection of the pipeline pressure during the infusion process; and / or The liquid injection device further includes an ultrasonic bubble sensor, and the ultrasonic bubble sensor is used to detect the bubble condition in the infusion pipeline.

5. An injection control method, characterized in that, The injection control method includes: Obtaining the target concentration of the mixed liquid medicine, and obtaining the target proportion of each original liquid medicine according to the target concentration; Controlling the multi-way control valve to open, and obtaining the current flow rate of the original liquid medicine in each channel; Judging whether the current flow rate ratio of the original liquid medicine in each channel matches the target proportion; If not, controlling the multi-way control valve to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion.

6. The injection control method according to claim 5, characterized in that Controlling the multi-way control valve to adjust the opening degree of the corresponding channel until the current flow rate ratio is consistent with the target proportion, including: Controlling the multi-way control valve to increase the opening degree of the channel with a large proportion of the original liquid medicine, and / or reducing the opening degree of the channel with a small proportion of the original liquid medicine until the current flow rate ratio is consistent with the target proportion.

7. The injection control method according to claim 5, characterized in that, The injection control method further includes: Obtaining the initial temperature of the original liquid medicine and the current ambient temperature, and evaluating the current viscosity of the mixed liquid medicine according to the current infusion duration, the current ambient temperature, the initial temperature and the target concentration; Obtaining the current output flow rate of the mixed liquid medicine, and judging whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold; If so, obtain the target opening degree corresponding to the multi-channel control valve according to the target flow rate and the current viscosity of the mixed liquid medicine; Adjust the current opening degree of each channel of the multi-channel control valve to the target opening degree.

8. The injection control method according to claim 7, characterized in that Judge whether the deviation between the current output flow rate and the target flow rate is greater than or equal to a preset threshold. After that, it further includes: If it is judged that the deviation between the current output flow rate and the target flow rate is less than the preset threshold, or the opening degree of any one channel in the multi-channel control valve reaches the maximum adjustment value, obtain the target rotation speed corresponding to the driving pump according to the target flow rate, the current viscosity of the mixed liquid medicine and the current opening degree of the multi-channel control valve; Adjust the current rotation speed of the driving pump to the target rotation speed.

9. The injection control method according to claim 8, characterized in that, Adjusting the current rotation speed of the driving pump to the target rotation speed includes: Calculate the adjusted pipeline pressure according to the target rotation speed and the current viscosity of the mixed liquid medicine; If the calculated pipeline pressure is less than the preset maximum pressure, execute adjusting the current rotation speed of the driving pump to the target rotation speed; If the calculated pipeline pressure is greater than or equal to the preset maximum pressure, do not execute adjusting the current rotation speed of the driving pump to the target rotation speed.

10. The injection control method according to any one of claims 7-9, characterized in that, The injection control method further includes: Obtain the current pressure value of the pipeline; If the current pressure value is greater than or equal to the preset maximum pressure, trigger controlling the driving pump to reduce speed and / or controlling the multi-channel control valve to reduce the current opening degree; Judge whether the current viscosity of the mixed liquid medicine is greater than the preset viscosity; If so, control the temperature compensator to start heating the liquid medicine until the current temperature of the liquid medicine reaches the preset temperature.

Images