Degradation experiment device for alginate hydrogel

Abstract

The invention discloses a degradation experiment device for alginate hydrogel, and belongs to the technical field of degradation experiment devices.The degradation experiment device comprises a liquid conveying device, a flow divider, a plurality of sample chambers and a plurality of body fluid recycling pools which are sequentially arranged from top to bottom, and a first pipeline is connected between the liquid conveying device and a main channel of the flow divider; a first pipeline is installed on the flow divider, a check valve is installed on the first pipeline, branch channels of the flow divider correspond to the sample chambers in a one-to-one mode, second pipelines are installed between the branch channels of the flow divider and the corresponding sample chambers, flow speed regulators are installed on the second pipelines, and the sample chambers correspond to the body fluid recycling pools in a one-to-one mode. And a pipeline III is connected between the sample chamber and the corresponding body fluid recovery pool. The method has the effect of improving the test efficiency.

Description

Technical Field

[0001] This application relates to the technical field of degradation test devices, and in particular to a degradation experiment device for alginate hydrogels. Background Art

[0002] Alginate hydrogels are a type of natural polymer material with excellent biocompatibility and biodegradability, and are widely used in many fields such as drug delivery, wound dressings, food packaging, and environmental protection. Especially in the medical field, alginate hydrogels have become an important drug delivery system or tissue engineering material in clinical treatment because they can simulate the biological tissue environment and have good biodegradability. Studying the degradation time and degradation law of calcium alginate gels provides basic data support for implanting calcium alginate gels in the body. By controlling the degradation rate and method, applications such as drug sustained release, tissue engineering, and biomedical fields can be realized. Therefore, the research on the degradation of alginate hydrogels has important scientific significance and application value.

[0003] In order to study the degradation performance of alginate hydrogels, usually ultra-pure sodium alginate is made into a gel, and after obtaining the alginate hydrogel, it is placed in an in vitro simulated body fluid environment to simulate the degradation of the alginate hydrogel in the body, and the degradation rate is calculated according to the mass change of the alginate hydrogel. However, the body fluid flow rates in different parts of the human body are different, and experimental operators need to control different simulated body fluid flow rates for the experiment, and the experimental operation is relatively cumbersome. Summary of the Invention

[0004] In order to improve the problem that experimental operators need to simulate the body fluid flow rates in different parts of the human body for the experiment, this application provides a degradation experiment device for alginate hydrogels.

[0005] A degradation experiment device for alginate hydrogels provided by this application adopts the following technical solutions: A degradation experiment device for alginate hydrogels includes an infusion device, a flow divider, a plurality of sample chambers, and a plurality of body fluid recovery pools arranged in sequence from top to bottom. A pipeline one is connected between the infusion device and the main channel of the flow divider, and a stop valve is installed on the pipeline one. The branch channels of the flow divider correspond to the sample chambers one by one. A pipeline two is installed between the branch channel of the flow divider and the corresponding sample chamber, and a flow rate regulator is installed on the pipeline two. The sample chambers correspond to the body fluid recovery pools one by one, and a pipeline three is connected between the sample chamber and the corresponding body fluid recovery pool.

[0006] By adopting the above technical solution, the alginate hydrogel is placed in the sample chamber, and then the simulated body fluid is placed in the infusion device. The stop valve is opened, and the simulated body fluid enters the shunt through pipeline 1. The simulated body fluid in the shunt enters the sample chamber through the branch channels and pipeline 2, flows through the alginate hydrogel in the sample chamber, and then flows into the body fluid recovery pool through pipeline 3. The flow rate regulator can adjust the flow rate of the simulated body fluid in different pipeline 2s to make the flow rate of the simulated body fluid consistent with the flow rate of the body fluid in different parts of the human body, and then simulate the degradation rate of the alginate hydrogel in different parts of the human body for experimental testing. The operation is simple and the experimental efficiency is relatively high.

[0007] Preferably, the sample chamber includes an installation sleeve for placing the sample. A step joint is installed at the bottom of the installation sleeve. The top end of the step joint is fixedly connected to the bottom of the installation sleeve, and the bottom end of the step joint is communicated with pipeline 3.

[0008] By adopting the above technical solution, the stop valve is closed, and then the step joint is removed, and the alginate hydrogel in the installation sleeve can be taken out and weighed. The degradation rate of the alginate hydrogel can be calculated according to the mass change of the alginate hydrogel. The operation is simple and the experimental cost is relatively low.

[0009] Preferably, it further includes a temperature control device. The temperature control device includes a water tank. An electric heating wire is arranged on the inner wall of the water tank. A limiting frame for placing the infusion device is fixed on the inner bottom surface of the water tank. A plurality of through holes 1 are opened on the side surfaces of the limiting frame. A pressing plate is arranged on the limiting frame. The bottom surface of the pressing plate can be abutted against the infusion device. A plurality of through holes 2 are opened on the top surface of the pressing plate. A relief groove for placing pipeline 1 is opened on the top surface of the limiting frame. An extrusion assembly for extruding the infusion device is arranged in the limiting frame.

[0010] By adopting the above technical solution, the infusion device is placed in the limiting frame, and then pipeline 1 is passed through the relief groove. The pressing plate abuts against the top of the infusion device, thereby limiting the infusion device. The extrusion assembly is used to extrude the infusion device, so that the simulated body fluid in the infusion device flows downward through pipeline 1. The water temperature in the water tank can be controlled by the electric heating wire, so that the simulated body fluid in the infusion device is kept at a constant temperature, reducing the influence of temperature change on the test result. At the same time, the degradation rate of the alginate hydrogel can be tested at different body fluid temperatures to understand the influence of different body fluid temperatures on the degradation rate of the alginate hydrogel.

[0011] Preferably, the extrusion assembly includes an extrusion roller. Sliding grooves are respectively formed in the opposite inner sides of the limiting frame. Sliders are respectively arranged at both ends of the extrusion roller. The sliders are slidably matched with the limiting frame along the length direction of the limiting frame through the sliding grooves. A moving through groove is formed in one side of the limiting frame away from the pipeline, and the extrusion roller can move into the moving through groove.

[0012] By adopting the above technical solution, in the initial state, the extrusion roller is located in the moving through groove. The infusion device is placed in the limiting frame. The extrusion roller is located on the side of the infusion device away from the pipeline. The extrusion roller is moved towards the direction close to the pipeline 1, and the extrusion roller extrudes the infusion device, so that the simulated body fluid in the infusion device can smoothly flow into the pipeline 1.

[0013] Preferably, a driving screw is rotatably installed in one of the sliding grooves. The driving screw passes through the slider, and the slider is in threaded transmission cooperation with the driving screw. A motor is fixed on the side surface of the limiting frame, and the output end of the motor is fixedly connected to the end of the driving screw.

[0014] By adopting the above technical solution, the motor is started. The motor drives the driving screw to rotate. The driving screw drives the slider to move, and then drives the extrusion roller to move towards the direction close to the pipeline 1.

[0015] Preferably, rotating rods are respectively fixed at both ends of the extrusion roller. The rotating rods are rotatably connected to the sliders. A first bevel gear is sleeved and fixed on the outer circumference of one of the rotating rods. A second bevel gear is sleeved on the outer circumference of the driving screw. The second bevel gear meshes with the first bevel gear. A synchronous block is fixed on the inner peripheral surface of the second bevel gear. A synchronous groove is formed on the outer peripheral surface of the driving screw. The synchronous block is slidably matched with the driving screw along the length direction of the driving screw through the synchronous groove.

[0016] By adopting the above technical solution, the driving screw drives the second bevel gear to rotate through the synchronous block and the synchronous groove. The second bevel gear drives the first bevel gear to rotate. The first bevel gear drives the rotating rod to rotate, and then drives the extrusion roller to rotate.

[0017] Preferably, two fixing blocks are fixed on the top surface of the limiting frame. A fixing rod is rotatably installed between the two fixing blocks. The pressing plate is sleeved on the outer circumference of the fixing rod. The bottom surface of the pressing plate can abut against the top surface of the limiting frame. A torsion spring is sleeved on the outer circumference of the fixing rod. One end of the torsion spring is fixedly connected to the fixing block, and the other end of the torsion spring is fixedly connected to the pressing plate.

[0018] By adopting the above technical solution, after opening the pressing plate and placing the infusion device into the limiting frame, the pressing plate rotates downward under the elastic force of the torsion spring and abuts against the top surface of the limiting frame, and the bottom surface of the pressing plate fits with the infusion device, thereby limiting the infusion device.

[0019] Preferably, the first pipe includes a first connecting pipe connected to the infusion device and a second connecting pipe connected to the shunt. A buffer sleeve is connected between the first connecting pipe and the second connecting pipe. A control groove is formed on the inner top surface of the buffer sleeve. A control block is slidably installed vertically in the buffer sleeve through the control groove. A moving contact piece is fixed on the side surface of the control block. A moving groove is formed on the inner wall of the control groove. The moving contact piece is slidably matched with the buffer sleeve vertically through the moving groove. A fixed contact piece for making electrical contact with the moving contact piece is fixed on the inner bottom surface of the moving groove. The fixed contact piece is electrically connected to a power source, and the moving contact piece is electrically connected to the motor. A floating ring is slidably installed vertically in the buffer sleeve. The top surface of the floating ring can abut against the bottom surface of the control block.

[0020] By adopting the above technical solution, when the motor is started and the squeezing roller squeezes the infusion device, the simulated body fluid in the infusion device enters the buffer sleeve through the first connecting pipe and then enters the shunt through the second connecting pipe. When the body fluid in the buffer sleeve gradually increases, the floating ring moves upward and abuts against the control block, and then pushes the control block upward, causing the moving contact piece to separate from the fixed contact piece, the motor is powered off, and the squeezing roller stops moving, thereby reducing the possibility of the infusion device bursting after being strongly squeezed.

[0021] Preferably, a pressing block is fixed on the side surface of the control block. A pressing groove is formed on the inner wall of the control groove. The pressing block is slidably matched with the buffer sleeve vertically through the pressing groove. A pressing spring is fixed on the top surface of the pressing block. The top end of the pressing spring is fixedly connected to the inner top surface of the pressing groove.

[0022] By adopting the above technical solution, when the floating ring does not contact the control block, the control block keeps the moving contact piece and the fixed contact piece in electrical contact under the elastic force of the pressing spring, so that the motor is powered on and works.

[0023] Preferably, a vertically arranged guide rod is fixed in the buffer sleeve. The guide rod passes through the floating ring, and the floating ring slides vertically through the guide rod.

[0024] By adopting the above technical solution, the guide rod provides a guiding effect on the floating ring, so that the floating ring always moves vertically, facilitating the floating ring to abut against the control block smoothly.

[0025] In summary, the present application includes at least one of the following beneficial technical effects: 1. Place the alginate hydrogel in the sample chamber, then place the simulated body fluid in the infusion device, open the stop valve, and the simulated body fluid enters the diverter through the pipe 1. The body fluid in the diverter enters the sample chamber through the branch channel and pipe 2, flows through the sample chamber (in which the alginate hydrogel is placed), and then flows into the body fluid recovery pool through pipe 3. The flow rate regulator can adjust the flow rate of the simulated body fluid in different pipes 2, so that the flow rate of the simulated body fluid is consistent with the flow rate of the body fluid in different parts of the human body, and then test the degradation rate of the alginate hydrogel in different parts of the human body. The operation is simple and the test efficiency is high. 2. Close the stop valve and remove the pagoda joint, then you can take out the alginate hydrogel in the installation sleeve and weigh it. According to the change in the mass of the alginate hydrogel, the degradation rate of the alginate hydrogel is calculated. The operation is simple and the test cost is low. 3. Place the infusion device in the limit frame, pass pipe 1 through the make way slot, and make the pressure plate abut against the top of the infusion device to limit the infusion device. Use the extrusion assembly to squeeze the infusion device so that the simulated body fluid in the infusion device flows downward through pipe 1. The water temperature in the water tank can be controlled by the heating wire to keep the simulated body fluid in the infusion device at a constant temperature, thereby reducing the impact of temperature changes on the test results. At the same time, the temperature can be adjusted to simulate the degradation rate of alginate hydrogel at different body fluid temperatures and understand the impact of different body fluid temperatures on the degradation rate of alginate hydrogel. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of Example 1 of the present application.

[0027] Figure 2 It is a schematic diagram of the overall structure of Example 2 of the present application.

[0028] Figure 3 It is a cross-sectional view of the water tank in Example 2 of the present application.

[0029] Figure 4 It is a schematic diagram of the structure of the extrusion roller in Example 2 of the present application.

[0030] Figure 5 It is a schematic diagram of the structure of the pressure plate in Example 2 of the present application.

[0031] Figure 6 It is a cross-sectional view of the slider in Example 2 of the present application.

[0032] Figure 7 It is a cross-sectional view of the buffer sleeve in Example 2 of the present application.

[0033] Figure 8 yes Figure 7 A magnified schematic diagram of center A.

[0034] Reference numerals: 1, infusion device; 11, first pipeline; 111, first connecting pipe; 112, second connecting pipe; 12, stop valve; 13, diverter; 14, second pipeline; 15, flow rate regulator; 16, sample chamber; 161, mounting sleeve; 162, step nipple; 17, third pipeline; 18, body fluid recovery pool; 2, temperature control device; 21, water tank; 22, heating wire; 23, limiting frame; 231, first through hole; 24, relief groove; 25, slider; 26, chute; 27, moving through groove; 3, pressing plate; 31, fixing block; 32, fixing rod; 33, torsion spring; 34, second through hole; 4, pressing roller; 41, driving screw; 412, synchronous groove; 42, motor; 43, rotating rod; 44, first bevel gear; 45, second bevel gear; 46, synchronous block; 5, buffer sleeve; 51, control block; 52, control groove; 53, pressing block; 54, pressing groove; 55, pressing spring; 56, moving contact; 57, moving groove; 58, fixed contact; 6, floating ring; 61, guide rod. Detailed implementation mode

[0035] The following further elaborates on this application Figures 1-8 in conjunction with the attached drawings.

[0036] This application discloses a degradation experiment device for alginate hydrogel.

[0037] Example 1 Referring to Figure 1 , the degradation experiment device for alginate hydrogel includes an infusion device 1, a diverter 13, a plurality of sample chambers 16 and a plurality of body fluid recovery pools 18 arranged in sequence from top to bottom. The infusion device 1 can be an infusion bag, an infusion bottle, etc. A first pipeline 11 is connected between the infusion device 1 and the main channel of the diverter 13. The first pipeline 11 can be a plastic pipe, a rubber pipe, a glass pipe, etc. A stop valve 12 is installed on the first pipeline 11. The branch channels of the diverter 13 correspond to the sample chambers 16 one by one. A second pipeline 14 is installed between the branch channel of the diverter 13 and the corresponding sample chamber 16. A flow rate regulator 15 is installed on the second pipeline 14. The sample chambers 16 correspond to the body fluid recovery pools 18 one by one. A third pipeline 17 is connected between the sample chamber 16 and the corresponding body fluid recovery pool 18.

[0038] Referring to Figure 1, the sample chamber 16 includes a mounting sleeve 161 for placing samples, and a stepped joint 162 is installed at the bottom of the mounting sleeve 161. The top end of the stepped joint 162 is fixedly connected to the bottom of the mounting sleeve 161, and the bottom end of the stepped joint 162 is communicated with the third pipe 17. After the degradation experiment is completed, close the stop valve 12, and then remove the stepped joint 162, and the alginate hydrogel in the mounting sleeve 161 can be taken out, weighed, and the degradation rate of the alginate hydrogel can be calculated according to the mass change of the alginate hydrogel.

[0039] The implementation principle of Embodiment 1 of this application is: place the alginate hydrogel in the sample chamber 16, then place the simulated body fluid in the infusion device 1, open the stop valve 12, the simulated body fluid enters the diverter 13 through the first pipe 11, and the body fluid in the diverter 13 enters the sample chamber 16 through the branch channels and the second pipe 14, and flows into the body fluid recovery pool 18 through the third pipe 17 after flowing through the alginate hydrogel in the sample chamber 16. The flow rate regulator 15 can adjust the flow rate of the simulated body fluid in different second pipes 14 to make the flow rate of the simulated body fluid consistent with the flow rate of the body fluid in different parts of the human body, so as to test the degradation rate of the alginate hydrogel in different parts of the human body. The operation is simple and the test efficiency is relatively high.

[0040] Embodiment 2 Refer to Figure 2 , Figure 3 and Figure 4 , the difference between Embodiment 2 and Embodiment 1 is that it further includes a temperature control device 2. The temperature control device 2 includes a water tank 21, and an electric heating wire 22 is arranged on the inner wall of the water tank 21. The water temperature in the water tank 21 can be controlled by controlling the electric heating wire 22. A limiting frame 23 for placing the infusion device 1 is fixedly installed on the inner bottom surface of the water tank 21. A plurality of through holes 231 are opened on the side surfaces of the limiting frame 23, and a relief groove 24 for placing the first pipe 11 is opened on the top surface of the limiting frame 23. The sample chamber 16 is arranged in a thermostatic and humidistatic chamber, and the temperature in the sample chamber 16 is maintained by the thermostatic and humidistatic chamber. Refer to Figure 4 and Figure 5 , two fixing blocks 31 are fixedly installed on the top surface of the limiting frame 23, and a fixing rod 32 is rotatably installed between the two fixing blocks 31. A pressing plate 3 is sleeved on the outer periphery of the fixing rod 32, and a plurality of through holes 34 are opened on the top surface of the pressing plate 3. A torsion spring 33 is sleeved on the outer periphery of the fixing rod 32. One end of the torsion spring 33 is fixedly connected to the fixing block 31, and the other end of the torsion spring 33 is fixedly connected to the pressing plate 3. Open the pressing plate 3, place the infusion device 1 in the limiting frame 23, and then pass the first pipe 11 through the relief groove 24. The pressing plate 3 rotates downward under the elastic force of the torsion spring 33 and abuts against the top surface of the limiting frame 23, and the bottom surface of the pressing plate 3 fits with the infusion device 1, so as to limit the infusion device 1.

[0041] Refer toFigure 4 and Figure 6 , chute 26 is respectively provided in the relative interior of the limiting frame 23, and the limiting frame 23 is slidably installed with a slider 25 along its own length direction through the chute 26. An extrusion roller 4 is rotatably installed between the two sliders 25. A moving through groove 27 is provided on the side of the limiting frame 23 away from the first pipe 11, and the extrusion roller 4 can move into the moving through groove 27. A driving screw rod 41 is rotatably installed in one of the chutes 26, the driving screw rod 41 passes through the slider 25, and the slider 25 is in threaded transmission cooperation with the driving screw rod 41. A motor 42 is fixed on the side surface of the limiting frame 23, and the output end of the motor 42 is fixedly connected to the end of the driving screw rod 41. Rotating rods 43 are respectively fixed at both ends of the extrusion roller 4, and the rotating rods 43 are rotatably connected to the sliders 25. A first bevel gear 44 is sleeved and fixed on the outer periphery of one of the rotating rods 43, a second bevel gear 45 is sleeved on the outer periphery of the driving screw rod 41, and the second bevel gear 45 meshes with the first bevel gear 44. A synchronizing block 46 is fixed on the inner peripheral surface of the second bevel gear 45, a synchronizing groove 412 is provided on the outer peripheral surface of the driving screw rod 41, and the synchronizing block 46 is slidably matched with the driving screw rod 41 along the length direction of the driving screw rod 41 through the synchronizing groove 412.

[0042] In the initial state, the extrusion roller 4 is located in the moving through groove 27. Start the motor 42, the motor 42 drives the driving screw rod 41 to rotate, the driving screw rod 41 drives the slider 25 to move, and then drives the extrusion roller 4 to move towards the direction close to the first pipe 11. At the same time, the driving screw rod 41 drives the second bevel gear 45 to rotate through the synchronizing block 46 and the synchronizing groove 412, the second bevel gear 45 drives the first bevel gear 44 to rotate, the first bevel gear 44 drives the rotating rod 43 to rotate, and then drives the extrusion roller 4 to rotate. The extrusion roller 4 extrudes the infusion device 1, so that the simulated body fluid in the infusion device 1 smoothly flows into the first pipe 11.

[0043] Refer to Figure 2 , Figure 7 and Figure 8 , the first pipe 11 includes a first connecting pipe 111 connected to the infusion device 1 and a second connecting pipe 112 connected to the diverter 13. A buffer sleeve 5 is connected between the first connecting pipe 111 and the second connecting pipe 112. A control groove 52 is provided on the inner top surface of the buffer sleeve 5, and a control block 51 is slidably installed in the buffer sleeve 5 along the vertical direction through the control groove 52. A pressing block 53 is fixed on the side surface of the control block 51, a pressing groove 54 is provided on the inner wall of the control groove 52, and the pressing block 53 is slidably matched with the buffer sleeve 5 along the vertical direction through the pressing groove 54. A pressing spring 55 is fixed on the top surface of the pressing block 53, and the top end of the pressing spring 55 is fixedly connected to the inner top surface of the pressing groove 54.

[0044] Refer to Figure 7 and Figure 8A moving contact piece 56 is fixed to the side of the control block 51, and a moving groove 57 is provided on the inner wall of the control groove 52. The moving contact piece 56 slides and cooperates with the buffer sleeve 5 in the vertical direction through the moving groove 57. A fixed contact piece 58 for electrical contact with the moving contact piece 56 is fixed to the inner bottom surface of the moving groove 57. The fixed contact piece 58 is electrically connected to the power supply, and the moving contact piece 56 is electrically connected to the motor 42. A vertically arranged guide rod 61 is fixed in the buffer sleeve 5. A floating ring 6 is sleeved on the outer periphery of the guide rod 61. The floating ring 6 slides vertically through the guide rod 61, and the top surface of the floating ring 6 can abut against the bottom surface of the control block 51.

[0045] When the motor 42 is started and the squeezing roller 4 squeezes the infusion device 1, the simulated body fluid in the infusion device 1 enters the buffer sleeve 5 through the connecting tube 1 111, and then enters the diverter 13 through the connecting tube 2 112. When the body fluid in the buffer sleeve 5 gradually increases, the floating ring 6 moves upward and abuts against the control block 51, thereby pushing the control block 51 to move upward, so that the moving contact piece 56 is separated from the fixed contact piece 58, the motor 42 is powered off, and the squeezing roller 4 stops moving, thereby reducing the possibility of the infusion device 1 bursting after being strongly squeezed.

[0046] The implementation principle of Example 2 of the present application is: the infusion device 1 is placed in the limit frame 23, and then the pipe 11 is passed through the make way groove 24, the pressure plate 3 is abutted against the top of the infusion device 1, so as to limit the infusion device 1, and the infusion device 1 is squeezed by the squeezing assembly so that the simulated body fluid in the infusion device 1 flows downward through the pipe 11. The water temperature in the water tank 21 can be controlled by the heating wire 22, so that the simulated body fluid in the infusion device 1 is kept at a constant temperature, reducing the impact of temperature changes on the test results. At the same time, the degradation rate of alginate hydrogel at different body fluid temperatures can be tested to understand the impact of different body fluid temperatures on the degradation rate of alginate hydrogel.

[0047] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. An experimental device for the degradation of alginate hydrogel, characterized in that: It includes an infusion device (1), a diverter (13), a number of sample chambers (16) and a number of body fluid recovery pools (18) arranged successively from top to bottom. A pipe one (11) is connected between the infusion device (1) and the main channel of the diverter (13). A stop valve (12) is installed on the pipe one (11). The branch channels of the diverter (13) correspond to the sample chambers (16) one by one. A pipe two (14) is installed between the branch channel of the diverter (13) and the corresponding sample chamber (16). A flow rate regulator (15) is installed on the pipe two (14). The sample chambers (16) correspond to the body fluid recovery pools (18) one by one. A pipe three (17) is connected between the sample chamber (16) and the corresponding body fluid recovery pool (18).

2. The degradation experiment device of an alginate hydrogel according to claim 1, characterized in that: The sample chamber (16) includes a mounting sleeve (161) for placing a sample. A tower joint (162) is installed at the bottom of the mounting sleeve (161). The top end of the tower joint (162) is fixedly connected to the bottom of the mounting sleeve (161). The bottom end of the tower joint (162) is communicated with the pipe three (17).

3. The degradation experiment device of an alginate hydrogel according to claim 2, characterized in that: It further includes a temperature control device (2). The temperature control device (2) includes a water tank (21). A heating wire (22) is arranged on the inner wall of the water tank (21). A limit frame (23) for placing the infusion device (1) is fixed on the inner bottom surface of the water tank (21). A number of through holes one (231) are opened on the side surfaces of the limit frame (23). A pressing plate (3) is arranged on the limit frame (23). The bottom surface of the pressing plate (3) can be abutted against the infusion device (1). A number of through holes two (34) are opened on the top surface of the pressing plate (3). A relief groove (24) for placing the pipe one (11) is opened on the top surface of the limit frame (23). An extrusion assembly for extruding the infusion device (1) is arranged in the limit frame (23).

4. The degradation experiment device of an alginate hydrogel according to claim 3, characterized in that: The extrusion assembly includes an extrusion roller (4). Sliding grooves (26) are respectively opened on the opposite inner sides of the limit frame (23). Sliders (25) are respectively arranged at both ends of the extrusion roller (4). The sliders (25) are slidably matched with the limit frame (23) along the length direction of the limit frame (23) through the sliding grooves (26). A moving through groove (27) is opened on one side of the limit frame (23) away from the pipe one (11). The extrusion roller (4) can move into the moving through groove (27).

5. The degradation experiment device of an alginate hydrogel according to claim 4, characterized in that: A driving screw rod (41) is rotatably installed in one of the sliding grooves (26). The driving screw rod (41) passes through the slider (25). The slider (25) is in threaded transmission cooperation with the driving screw rod (41). A motor (42) is fixed on the side surface of the limit frame (23). The output end of the motor (42) is fixedly connected to the end of the driving screw rod (41).

6. The degradation experimental device of an alginate hydrogel according to claim 5, characterized in that: Both ends of the extrusion roller (4) are respectively fixed with a rotating rod (43), the rotating rod (43) is rotatably connected to the slider (25), a first bevel gear (44) is sleeved and fixed on the outer periphery of one of the rotating rods (43), a second bevel gear (45) is sleeved on the outer periphery of the driving screw rod (41), the second bevel gear (45) meshes with the first bevel gear (44), a synchronous block (46) is fixed on the inner peripheral surface of the second bevel gear (45), a synchronous groove (412) is formed on the outer peripheral surface of the driving screw rod (41), and the synchronous block (46) is slidably matched with the driving screw rod (41) along the length direction of the driving screw rod (41) through the synchronous groove (412).

7. An experimental device for the degradation of alginate hydrogel according to claim 3, characterized in that: Two fixing blocks (31) are fixed on the top surface of the limiting frame (23), a fixing rod (32) is rotatably installed between the two fixing blocks (31), the pressing plate (3) is sleeved on the outer periphery of the fixing rod (32), the bottom surface of the pressing plate (3) can be abutted against the top surface of the limiting frame (23), a torsion spring (33) is sleeved on the outer periphery of the fixing rod (32), one end of the torsion spring (33) is fixedly connected to the fixing block (31), and the other end of the torsion spring (33) is fixedly connected to the pressing plate (3).

8. The degradation experimental device of an alginate hydrogel according to claim 5, characterized in that: The first pipeline (11) includes a first connecting pipe (111) connected to the infusion device (1) and a second connecting pipe (112) connected to the shunt (13), a buffer sleeve (5) is connected between the first connecting pipe (111) and the second connecting pipe (112), a control groove (52) is formed on the inner top surface of the buffer sleeve (5), a control block (51) is slidably installed vertically in the buffer sleeve (5) through the control groove (52), a moving contact piece (56) is fixed on the side surface of the control block (51), a moving groove (57) is formed on the inner wall of the control groove (52), the moving contact piece (56) is slidably matched with the buffer sleeve (5) vertically through the moving groove (57), a fixed contact piece (58) for making electrical contact with the moving contact piece (56) is fixed on the inner bottom surface of the moving groove (57), the fixed contact piece (58) is electrically connected to a power supply, the moving contact piece (56) is electrically connected to the motor (42), a floating ring (6) is slidably installed vertically in the buffer sleeve (5), and the top surface of the floating ring (6) can be abutted against the bottom surface of the control block (51).

9. An experimental device for the degradation of an alginate hydrogel according to claim 8, characterized in that: A pressing block (53) is fixed on the side surface of the control block (51), a pressing groove (54) is formed on the inner wall of the control groove (52), the pressing block (53) is slidably matched with the buffer sleeve (5) vertically through the pressing groove (54), a pressing spring (55) is fixed on the top surface of the pressing block (53), and the top end of the pressing spring (55) is fixedly connected to the inner top surface of the pressing groove (54).

10. An experimental device for the degradation of an alginate hydrogel according to claim 8, characterized in that: A vertically arranged guide rod (61) is fixed in the buffer sleeve (5), the guide rod (61) passes through the floating ring (6), and the floating ring (6) slides vertically through the guide rod (61).

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