Production and processing method of medicine for treating burns and scalds

Abstract

The invention belongs to the technical field of medicine for burns and scalds, and discloses a production and processing method of medicine for burns and scalds, which comprises the following specific steps: step 1, preparing raw materials, and treating sanguisorba officinalis: putting the sanguisorba officinalis raw materials into a clean stainless steel container; the convergence and tissue regeneration promoting effects of garden burnet are combined with the healing promoting and scar preventing characteristics of elm / jujube endothelium, so that the excessive proliferation of fibroblasts and the abnormal deposition of collagen are inhibited, and scar formation is reduced from the source; dual anti-inflammatory analgesic components of cortex phellodendri and borneol permeate into the deep layer of the wound surface, so that pain is quickly relieved, release of inflammatory factors is blocked, and the risk of secondary infection is reduced; the bleeding stopping and blood activating functions of pseudo-ginseng are combined with active ingredients efficiently extracted by an alcohol dynamic soaking process, so that microcirculation reconstruction and tissue repair are accelerated; the multi-stage filtration and ultraviolet sterilization technology thoroughly removes impurities and microorganisms in the liquid medicine, and nitrogen sub-packaging is matched to isolate oxidation, so that the component stability and sterile safety are ensured; the processes of low-temperature crushing, condensation temperature control and the like retain the activity of thermosensitive components to the maximum extent.

Description

Technical Field

[0001] The present invention belongs to the technical field of burn and scald medicines, and specifically relates to a production and processing method of a burn and scald medicine. Background Art

[0002] Burn and scald refer to an acute trauma caused by the action of heat (such as fire, hot liquid, steam, high-temperature solid, etc.), current, chemical substances, radiation, etc. on the human body, resulting in damage to the skin and deep tissues. According to the depth of injury, burns and scalds can be divided into first-degree, superficial second-degree, deep second-degree, and third-degree, with the degree ranging from the superficial layer of the epidermis to the whole layer of the skin and even subcutaneous, muscle, or bone. Common symptoms include skin redness, pain, blisters, and the formation of eschars. In severe cases, it may cause infection, shock, dysfunction, and even endanger life.

[0003] Although traditional burn and scald treatment drugs can relieve wound inflammation and accelerate epidermal healing, their formulation designs mostly focus on single anti-inflammatory or promoting healing functions, with insufficient regulation of deep skin repair. Moreover, the extraction efficiency of active ingredients in the preparation process is low, and the sterilization means are imperfect, resulting in two common defects in practical applications: First, it is difficult for the active ingredients of the drug to inhibit the abnormal proliferation of fibroblasts and the excessive deposition of collagen, resulting in prominent scar hyperplasia after healing, seriously affecting the skin function and beauty of patients; Second, the traditional soaking or decocting process is prone to microbial residues in the medicinal materials. Coupled with the lack of long-acting antibacterial components in some drugs, the wound is easily invaded by common pathogenic bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa after use, leading to secondary infection and even sepsis, prolonging the rehabilitation period. Therefore, it needs to be improved. Summary of the Invention

[0004] In view of the deficiencies of the prior art, the present invention provides a production and processing method of a burn and scald medicine, which has the advantages of no scars and sequelae, non-toxicity, and no infection.

[0005] To achieve the above object, the present invention provides the following technical solution: A production and processing method of a burn and scald medicine, the specific steps are as follows:

[0006] Step 1: Raw material preparation

[0007] Processing of Sanguisorba officinalis: Put the Sanguisorba officinalis raw material into a clean stainless steel container, repeatedly rinse it with flowing water to remove the attached soil and impurities on the surface. After cleaning, drain the water, spread it out flat in a bamboo drying tray, and place it in a cool and ventilated place to dry naturally, avoiding direct sunlight to cause the loss of active ingredients. After the Sanguisorba officinalis is dried, put the dried Sanguisorba officinalis into a traditional Chinese medicine grinder and crush it to a particle size of 20 to 40 mesh, then put it into a sealed bag for standby;

[0008] Processing of Phellodendron amurense: Manually select Phellodendron amurense medicinal materials, remove defective products with insect damage, mildew or abnormal color, evenly spread the qualified Phellodendron amurense on the dryer tray, and then use a traditional Chinese medicine grinder to process the dried Phellodendron amurense into coarse powder with a particle size of about 10-20 mesh, and store it sealed and away from light;

[0009] Processing of elm and jujube tree inner bark: Select elm or jujube tree branches with a diameter of more than 5 cm, longitudinally cut the bark with a disinfected knife, peel off the fresh inner bark, gently scrape off the brown rough bark attached to the surface of the inner bark with a scraper, and only retain the milky white or light yellow inner bark layer. Cut the inner bark into filaments with a width of 2 to 3 mm, spread them flat on a stainless steel mesh sieve, and then place the stainless steel mesh sieve in a constant temperature drying oven at 50 °C, turn it over every 2 hours, and dry for 6 to 8 hours until it is brittle and easy to break;

[0010] Processing of borneol: Directly select medicinal-grade natural borneol crystalline particles, after opening, sub-pack them into brown glass bottles and store them in a cool and dry place to avoid volatilization;

[0011] Processing of Panax notoginseng: Gently brush the floating dust on the surface of Panax notoginseng with a soft brush, strictly prohibit washing with water to prevent the loss of active ingredients, then place Panax notoginseng in a cold storage at -18 °C for 24 hours to reduce the fiber toughness, and then use an ultra-fine grinder to grind it into fine powder of 200 mesh in a low-temperature environment. After sieving, store it sealed;

[0012] Step Two: Preparation of Alcohol

[0013] Prepare an alcohol solution with a concentration of 60% to 62% according to the ratio of 1 ml of alcohol per gram of medicinal material;

[0014] Step Three: Dynamic Immersion

[0015] Layer by layer, spread the sanguisorba officinalis granules, Phellodendron amurense coarse powder, and inner bark filaments into the tank; inject the pre-prepared 60% to 62% alcohol solution into the tank through a pipeline, and the liquid level should be higher than the medicinal material layer; after the liquid injection is completed, fill the space at the top of the tank with nitrogen to displace the air and reduce the oxygen content in the tank to less than 3%;

[0016] After sealing the container, start the circulation device to make the medicinal liquid flow continuously to improve the component dissolution efficiency. During the immersion process, control the temperature between 35 and 40 °C, soak for 32 hours, regularly observe the color change of the medicinal liquid, and gently shake the container to make the medicinal materials evenly contact the solvent;

[0017] Step Four: Low-temperature Sedimentation and Filtration

[0018] After the immersion is completed, transfer the medicinal liquid to a low-temperature environment and let it stand for 24 hours. Control the ambient temperature at about -5 °C to promote the precipitation of colloid and impurities in the medicinal liquid, and then perform multi-stage filtration on the medicinal liquid; finally, let the medicinal liquid flow through an ultraviolet sterilization pipeline and receive 30 minutes of ultraviolet irradiation to kill microorganisms;

[0019] Step 5: Addition of Active Ingredients

[0020] Addition of Panax notoginseng powder: Under a sterile operation environment, take fine Panax notoginseng powder and put it into a glass mortar. Add a small amount of the sterilized medicinal liquid from Step 4. Use a grinding rod to gently draw circles in a clockwise direction to evenly moisten the powder with the medicinal liquid, forming a moist mass. Then continue grinding to gradually break the mass into a delicate paste. Subsequently, transfer the paste and the sterilized medicinal liquid from Step 4 to a homogenizer and disperse them at a speed of 3,000 revolutions per minute for ten minutes to ensure that the medicinal liquid is evenly distributed without lumps;

[0021] Addition of borneol: Place borneol in a water bath pot. The outer water bath temperature is kept constant at 35°C. Add 10 ml of 60% concentration alcohol to the water bath pot to dissolve borneol. Then slowly drip the dissolved borneol into the medicinal liquid while stirring clockwise with a glass rod until it is completely fused;

[0022] Step 6: Sub-packaging and Storage

[0023] Sub-pack the medicinal liquid into brown glass bottles. When filling, fill the bottles with nitrogen to isolate oxygen.

[0024] Preferably, when using high-concentration medical alcohol in Step 2, an appropriate amount of purified water needs to be added to adjust the concentration. During the preparation, glass or ceramic containers should be used to avoid contact with metal utensils.

[0025] Preferably, the raw materials in Step 1 are measured and proportioned by parts as follows: 70 to 100 parts of Sanguisorba officinalis, 50 to 100 parts of Phellodendron amurense, 1 to 60 parts of elm inner bark and / or jujube inner bark, 0.1 to 2 parts of borneol, 0.1 to 2 parts of Panax notoginseng. When elm inner bark and jujube inner bark are used together, their total amount is 1 to 60 parts. When using only one of the two, the amount of each is 1 to 60 parts.

[0026] Preferably, for the multi-stage filtration in Step 4, primary coarse filtration is first carried out. Wrap a 200-mesh stainless steel filter screen with double-layer sterile gauze to separate the upper floating foam and large-particle precipitates settling at the bottom of the container. During this stage, pay attention to the pouring angle of the medicinal liquid and slowly pour it along the container wall to avoid disturbing the bottom sediment layer. The coarsely filtered medicinal liquid is transferred to a clean ceramic cylinder, covered with food-grade filter paper, and left to stand for two hours to adsorb residual suspended matter by capillary action. Then, carry out two precision filtrations through a 0.22-micron microporous filter membrane. The medicinal liquid collected after the first filtration needs to be refluxed to the storage tank for mixing evenly, and then secondary filtration is carried out again to ensure that impurities are thoroughly removed, thereby completely separating fine impurities.

[0027] Preferably, after the borneol is dissolved in Step 5, the dissolved borneol alcohol solution needs to be quickly cooled to 15 - 20°C through a serpentine condenser. Cold water at 4°C is circulated on the outer wall of the condenser to prevent the volatilization of borneol.

[0028] Preferably, when drying the Phellodendron amurense in Step 1, the set temperature of the dryer is 60 °C, and drying is continued for 4 hours until the water content is less than 10%.

[0029] Preferably, when successively laying the Sanguisorba officinalis granules, the crude powder of Phellodendron amurense, and the inner bark filaments layer by layer into the tank in Step 3, after laying 5 cm thick medicinal materials each time, gently press and level them to ensure there are no large gaps between the materials. The final filling amount does not exceed 70% of the tank volume. Finally, use a filter screen to press and cover the top of the medicinal materials to prevent the medicinal materials from floating.

[0030] Preferably, when grinding the Panax notoginseng powder and the medicinal liquid in Step 5, the grinding time needs to be controlled within 15 to 20 minutes, and the grinding environment temperature is kept below 10 °C to prevent the degradation of the active ingredients of Panax notoginseng due to friction-induced temperature rise.

[0031] Preferably, during the dynamic soaking in Step 3, the flow rate of the circulation device is set at 5 to 8 liters per minute, and the pressure in the tank needs to be maintained within the range of 0.1 - 0.3 MPa to enhance the solvent penetration efficiency and shorten the dissolution time of the active ingredients.

[0032] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0033] The astringent and myogenic effect of Sanguisorba officinalis combined with the wound-healing and scar-preventing characteristics of the inner bark of elm / jujube inhibits the excessive proliferation of fibroblasts and abnormal deposition of collagen, reducing scar formation at the root; the dual anti-inflammatory and analgesic components of Phellodendron amurense and borneol penetrate deep into the wound surface, quickly relieve pain and block the release of inflammatory factors, reducing the risk of secondary infection; the hemostatic and blood-activating functions of Panax notoginseng combined with the active ingredients efficiently extracted by the dynamic soaking process with alcohol accelerate the reconstruction of microcirculation and tissue repair; the multi-stage filtration and ultraviolet sterilization technologies completely remove the impurities and microorganisms in the medicinal liquid, and nitrogen filling is used to isolate oxidation, ensuring the stability of the components and aseptic safety; processes such as low-temperature pulverization and condensation temperature control maximize the retention of the activity of thermosensitive components, enabling the drug to have multiple effects such as anti-infection, wound healing promotion, scar prevention, analgesia, and hemostasis. Specific Embodiments

[0034] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0035] The embodiments of the present invention provide a production and processing method for a burn and scald medicine, and the specific steps are as follows:

[0036] Step 1: Raw material preparation

[0037] Sanguisorba officinalis L. processing: Put the Sanguisorba officinalis L. raw materials into a clean stainless-steel container, rinse them repeatedly with flowing clear water to remove the attached soil and impurities on the surface. After cleaning, drain the water, lay them flat on a bamboo drying tray, and place them in a cool and ventilated place to dry naturally, avoiding direct sunlight that may cause the loss of active ingredients. After the Sanguisorba officinalis L. is dried, put the dried Sanguisorba officinalis L. into a traditional Chinese medicine grinder, grind it into particles with a size of 20 to 40 meshes, and put them into a sealed bag for standby;

[0038] Phellodendron amurense Rupr. processing: Manually select the Phellodendron amurense Rupr. medicinal materials, remove the defective products with insect damage, mildew or abnormal color. Spread the qualified Phellodendron amurense Rupr. evenly on the dryer tray, and then use a traditional Chinese medicine grinder to process the dried Phellodendron amurense Rupr. into coarse powder with a particle size of about 10 - 20 meshes, and store it in a sealed and light-proof manner;

[0039] Inner bark of Ulmus pumila L. and Ziziphus jujuba Mill. processing: Select the branches and trunks of Ulmus pumila L. or Ziziphus jujuba Mill. with a diameter of more than 5 cm, longitudinally cut the bark with a disinfected knife, peel off the fresh inner bark, gently scrape the brown rough bark attached to the surface of the inner bark with a scraper, and only retain the milky white or light yellow endodermis. Cut the inner bark into filaments with a width of 2 to 3 mm, lay them flat on a stainless-steel mesh sieve, and then place the stainless-steel mesh sieve in a constant-temperature drying oven at 50 °C, turn it over every 2 hours, and dry for 6 to 8 hours until the texture is brittle and easy to break;

[0040] Borneol processing: Directly select the medicinal-grade natural borneol crystal particles, after opening, sub-pack them into brown glass bottles, and store them in a cool and dry place to avoid volatilization;

[0041] Panax notoginseng processing: Gently brush the floating dust on the surface of Panax notoginseng with a soft brush. It is strictly prohibited to wash it with water to prevent the loss of active ingredients. Then place the Panax notoginseng in a cold storage at -18 °C for 24 hours to reduce the fiber toughness. Then use an ultrafine grinder to grind it into fine powder with 200 meshes under low-temperature environment, and store it in a sealed manner after sieving;

[0042] Step two: Alcohol preparation

[0043] Prepare an alcohol solution with a concentration of 60% to 62% according to the ratio of 1 ml of alcohol corresponding to 1 g of medicinal materials;

[0044] Step three: Dynamic soaking

[0045] Layer by layer, spread the Sanguisorba officinalis L. particles, Phellodendron amurense Rupr. coarse powder, and inner bark filaments into the tank; Inject the pre-prepared 60% to 62% alcohol solution into the tank through the pipeline, and the liquid level should be higher than the medicinal material layer; After the liquid injection is completed, fill the space at the top of the tank with nitrogen to displace the air, so that the oxygen content in the tank is reduced to less than 3%;

[0046] After sealing the container, start the circulation device to make the medicinal liquid flow continuously to improve the dissolution efficiency of the ingredients. During the soaking process, control the temperature between 35 and 40 °C, soak for 32 hours continuously, observe the color change of the medicinal liquid regularly, and gently shake the container to make the medicinal materials contact the solvent evenly;

[0047] Step Four: Low-temperature Sedimentation and Filtration

[0048] After the soaking is completed, transfer the liquid medicine to a low-temperature environment and let it stand for 24 hours. The environmental temperature is controlled at about minus 5 degrees Celsius to promote the precipitation of colloid and impurities in the liquid medicine, and then perform multi-stage filtration on the liquid medicine; finally, let the liquid medicine flow through an ultraviolet sterilization pipeline and receive 30 minutes of ultraviolet irradiation to kill microorganisms;

[0049] Step Five: Addition of Active Ingredients

[0050] Addition of Notoginseng Powder: Under a sterile operating environment, take fine notoginseng powder and put it into a glass mortar. Add a small amount of the liquid medicine that has been sterilized in Step Four, and gently draw circles in a clockwise direction with a grinding rod to evenly moisten the powder with the liquid medicine to form a moist mass. Then continue grinding and gradually break the mass into a delicate paste. Subsequently, transfer the paste and the liquid medicine that has been sterilized in Step Four to a homogenizer and disperse them at a speed of 3,000 revolutions per minute for 10 minutes to ensure that the liquid medicine is uniform and free of lumps;

[0051] Addition of Borneol: Place borneol in a water bath pot. The outer water bath temperature is kept constant at 35°C. Add 10 ml of 60% concentration alcohol to the water bath pot to dissolve borneol. Then slowly drip the dissolved borneol into the liquid medicine, and stir clockwise with a glass rod while dripping until completely fused;

[0052] Step Six: Sub-packaging and Storage

[0053] Sub-package the liquid medicine into brown glass bottles, and fill the bottles with nitrogen during filling to isolate oxygen.

[0054] After washing, drying and pulverizing the raw materials, soak the medicinal materials layer by layer with 60% to 62% alcohol to optimize the simultaneous dissolution of fat-soluble components and water-soluble components. Then remove colloid impurities through low-temperature standing, reduce microbial interference through ultraviolet sterilization, ensure the purity of the liquid medicine, and avoid the degradation of active ingredients. Then add active substances such as notoginseng powder and borneol. Among them, Sanguisorba officinalis can astringe and promote granulation, Phellodendron amurense can relieve inflammation and pain, endothelium can promote wound healing and prevent scarring, borneol can relieve pain and cool, and notoginseng can stop bleeding and promote blood circulation. The components complement each other to form a multi-treatment system for anti-inflammation, repair, promotion of healing and prevention of scarring, and finally achieve the comprehensive curative effects of quickly relieving the pain of burn and scald wounds, accelerating tissue regeneration, reducing infection and scar formation.

[0055] Among them, when using high-concentration medical alcohol in Step Two, an appropriate amount of pure water needs to be added to adjust the concentration. Glass or ceramic containers should be used during preparation to avoid contact with metal utensils.

[0056] By using glass or ceramic containers to prepare the alcohol solution, avoid chemical reactions that may be caused by metal utensils, ensure the stability and safety of the components of the liquid medicine, and at the same time optimize the extraction efficiency of active ingredients by adjusting the alcohol concentration.

[0057] Among them, for the raw materials in Step 1, the metered ratio by parts is 70 to 100 parts of Sanguisorba officinalis, 50 to 100 parts of Phellodendron amurense, 1 to 60 parts of elm inner bark and / or jujube inner bark, 0.1 to 2 parts of borneol, and 0.1 to 2 parts of Panax notoginseng. When elm inner bark and jujube inner bark are used together, their total amount is 1 to 60 parts. When only one of the two is used alone, the amount of each is 1 to 60 parts.

[0058] By precisely defining the ratio ranges of Sanguisorba officinalis, Phellodendron amurense, inner bark, borneol, and Panax notoginseng, it ensures the synergistic effect of the astringent hemostasis of Sanguisorba officinalis and the clearing heat and drying dampness of Phellodendron amurense, and also provides room for flexible adjustment of the dosage of the inner bark. Thus, the dosage of the inner bark can be increased or decreased according to the burn degree of the patient to adjust the medicinal properties. At the same time, the addition amounts of precious medicinal materials such as borneol and Panax notoginseng are strictly controlled, reducing the production cost on the premise of ensuring the curative effect and enhancing the practicability and adaptability of the process.

[0059] Among them, in Step 4, for the multi-stage filtration, primary rough filtration is carried out first. A two-hundred-mesh stainless steel filter screen is wrapped with a double-layer sterile gauze to separate the floating foam on the upper layer and the large-particle sediment deposited at the bottom of the container. In this stage, attention should be paid to the pouring angle of the liquid medicine, and it should be slowly poured along the wall of the container to avoid stirring the sediment layer at the bottom. The liquid medicine after rough filtration is transferred to a clean ceramic cylinder, covered with a food-grade filter paper on the surface, and left standing for two hours to adsorb the residual suspended matter by capillary action. Then, it is precisely filtered twice through a 0.22-micron microporous filter membrane. The liquid medicine collected after the first filtration needs to be refluxed to the storage tank and mixed evenly, and then secondary filtration is carried out again to ensure that the impurities are completely removed, thus completely separating the fine impurities.

[0060] The multi-stage filtration system removes large-particle impurities and colloidal precipitates through rough filtration, further captures suspended particles by static adsorption combined with food-grade filter paper, and finally realizes aseptic filtration through a 0.22-micron microporous filter membrane, which not only significantly improves the clarity of the liquid medicine but also greatly reduces the risk of microbial residue.

[0061] Among them, in Step 5, after borneol is dissolved, the dissolved borneol alcohol solution needs to be quickly cooled to 15 - 20 °C through a serpentine condenser, and 4 °C cold water is circulated on the outer wall of the condenser to prevent borneol from volatilizing.

[0062] After borneol is dissolved, it is quickly cooled to 15 - 20 °C through a serpentine condenser, and the temperature is controlled by external circulating cold water, effectively inhibiting the volatilization loss of borneol, ensuring the complete retention of its cool and pain-relieving components. The low-temperature environment also reduces the oxidation or decomposition of other thermosensitive components during the dissolution process, maintaining the overall stability of the liquid medicine.

[0063] Among them, in Step 1, when Phellodendron amurense is processed and dried, the temperature set by the dryer is 60 degrees Celsius, and it is continuously dried for 4 hours until the water content is lower than 10%.

[0064] By precisely controlling the temperature and duration during the drying of Phellodendron amurense, not only can moisture be efficiently removed to below 10% to prevent mildew or microbial growth, but also thermal decomposition of the active ingredients in Phellodendron amurense caused by high temperatures can be avoided, ensuring the maximization of the activity of the medicinal materials.

[0065] Among them, when the sanguisorba officinalis granules, the crude powder of Phellodendron amurense, and the inner skin filaments are sequentially laid into the tank layer by layer in step three, after laying 5 cm thick medicinal materials each time, gently press and level them to ensure there are no large gaps between the materials. The final filling amount does not exceed 70% of the tank volume. Finally, use a filter screen to press and cover the top of the medicinal materials to prevent the medicinal materials from floating.

[0066] By setting the filter screen to press and cover, the position of the medicinal materials is further fixed, preventing uneven dissolution caused by material displacement during the circulation process, thereby improving the extraction rate of the active ingredients and the uniformity of the liquid medicine concentration.

[0067] Among them, when the notoginseng powder and the liquid medicine are ground in step five, the grinding time needs to be controlled within 15 to 20 minutes, and the temperature of the grinding environment is maintained below 10°C to prevent the degradation of the active ingredients in notoginseng due to friction-induced temperature rise.

[0068] By strictly limiting the grinding time of notoginseng powder and maintaining a low-temperature environment below 10°C, heat generation due to friction is reduced to prevent the degradation of heat-sensitive components such as notoginsenosides and polysaccharides, maximizing the retention of its effects of promoting blood circulation and removing blood stasis and anti-inflammatory effects. At the same time, low-temperature grinding can also avoid powder caking, ensure the paste is delicate and uniform, enhance the mixing and dispersion with the liquid medicine, and ultimately improve the bioavailability and clinical efficacy of the finished medicine.

[0069] Among them, during the dynamic soaking in step three, the flow rate of the circulation device is set at 5 to 8 liters per minute, and the pressure in the tank needs to be maintained within the range of 0.1 - 0.3 MPa to enhance the solvent penetration efficiency and shorten the dissolution time of the active ingredients.

[0070] By adjusting the circulation flow rate and the pressure in the tank, the penetration and fluidity of the alcohol solution are enhanced, accelerating the release and dissolution of the active ingredients.

[0071] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "including", "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or elements inherent to such process, method, article or device.

[0072] Although embodiments of the present invention have been shown and described, those of ordinary skill in the art will appreciate that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A production and processing method of a burn and scald medicine, characterized in that, The specific steps are as follows: Step 1: Raw material preparation Sanguisorba officinalis L. processing: Put the Sanguisorba officinalis L. raw materials into a clean stainless-steel container, rinse them repeatedly with running water to remove the attached soil and impurities on the surface. After cleaning, drain the water, lay them flat in a bamboo drying tray, and place them in a cool and ventilated place to dry naturally, avoiding direct sunlight to cause the loss of active ingredients. After the Sanguisorba officinalis L. is dried, put the dried Sanguisorba officinalis L. into a traditional Chinese medicine grinder, grind it into particles with a size of 20 to 40 mesh, and pack them into a sealed bag for standby; Phellodendron amurense Rupr. processing: Manually select the Phellodendron amurense Rupr. medicinal materials, remove the defective products with insect damage, mildew or abnormal color. Spread the qualified Phellodendron amurense Rupr. evenly on the dryer tray, and then use a traditional Chinese medicine grinder to process the dried Phellodendron amurense Rupr. into coarse powder with a particle size of about 10 - 20 mesh, and store it sealed and away from light; Inner bark of Ulmus pumila L. and Ziziphus jujuba Mill. processing: Select the branches and trunks of Ulmus pumila L. or Ziziphus jujuba Mill. with a diameter of more than 5 cm, longitudinally cut the bark with a disinfected knife, peel off the fresh inner bark, gently scrape the brown rough bark attached to the surface of the inner bark with a scraper, and only retain the milky white or light yellow endodermis. Cut the inner bark into filaments with a width of 2 to 3 mm, lay them flat on a stainless-steel mesh sieve, and then place the stainless-steel mesh sieve in a constant-temperature drying oven at 50 °C, turn it over every 2 hours, and dry for 6 to 8 hours until the texture is brittle and easy to break; Borneol processing: Directly select the medicinal-grade natural borneol crystal particles, after opening, sub-pack them into brown glass bottles, and store them in a cool and dry place to avoid volatilization; Panax notoginseng processing: Gently brush the floating dust on the surface of Panax notoginseng with a soft brush, strictly prohibit washing with water to prevent the loss of active ingredients, then place Panax notoginseng in a cold storage at -18 °C for 24 hours to reduce the fiber toughness, and then use an ultra-fine grinder to grind it into fine powder of 200 mesh in a low-temperature environment, and store it sealed after sieving; Step 2: Alcohol preparation Prepare an alcohol solution with a concentration of 60% to 62% according to the ratio of 1 ml of alcohol per gram of medicinal materials; Step 3: Dynamic soaking Layer by layer, spread the Sanguisorba officinalis L. particles, Phellodendron amurense Rupr. coarse powder, and inner bark filaments into the tank; Inject the pre-prepared 60% to 62% alcohol solution into the tank through a pipeline, and the liquid level should be higher than the medicinal material layer; After the liquid injection is completed, fill the space at the top of the tank with nitrogen to displace the air, so that the oxygen content in the tank is reduced to less than 3%; After sealing the container, start the circulation device to make the medicinal liquid flow continuously to improve the component dissolution efficiency. During the soaking process, control the temperature between 35 and 40 °C, soak for 32 hours continuously, and regularly observe the color change of the medicinal liquid, and gently shake the container to make the medicinal materials contact the solvent evenly; Step 4: Low-temperature sedimentation and filtration After the soaking is completed, transfer the medicinal liquid to a low-temperature environment and let it stand for 24 hours, and control the environmental temperature at about -5 °C to promote the precipitation of colloid and impurities in the medicinal liquid, and then perform multi-stage filtration on the medicinal liquid; Finally, let the medicinal liquid flow through the ultraviolet sterilization pipeline and receive 30 minutes of ultraviolet irradiation to kill microorganisms; Step 5: Active ingredient addition Addition of Notoginseng Powder: Under a sterile operating environment, take fine notoginseng powder and put it into a glass mortar. Add a small amount of the sterilized liquid medicine from Step 4. Use a pestle to gently draw circles in a clockwise direction to evenly moisten the powder with the liquid medicine, forming a moist mass. Then continue grinding to gradually break the mass into a delicate paste. Subsequently, transfer the paste and the sterilized liquid medicine from Step 4 to a homogenizer and disperse them at a speed of 3,000 revolutions per minute for 10 minutes to ensure that the liquid medicine is evenly distributed without lumps. Addition of Borneol: Place borneol in a water bath pot. The outer water bath temperature is kept constant at 35°C. Add 10 ml of 60% concentration alcohol to the water bath pot to dissolve borneol. Then slowly drip the dissolved borneol into the liquid medicine, stirring clockwise with a glass rod while dripping until completely blended. Step 6: Subpackaging and Storage Subpackage the liquid medicine into brown glass bottles. When filling, fill the bottles with nitrogen to isolate oxygen.

2. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: When using high-concentration medical alcohol in Step 2, an appropriate amount of pure water needs to be added to adjust the concentration. Glass or ceramic containers should be used during preparation to avoid contact with metal utensils.

3. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: The raw materials described in Step 1 are measured and proportioned by parts as follows: 70 to 100 parts of Sanguisorba officinalis, 50 to 100 parts of Phellodendron amurense, 1 to 60 parts of elm inner bark and / or jujube inner bark, 0.1 to 2 parts of borneol, 0.1 to 2 parts of notoginseng. When elm inner bark and jujube inner bark are used together, their total amount is 1 to 60 parts. When using only one of the two alone, the amount of each is 1 to 60 parts.

4. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: For the multi-stage filtration described in Step 4, first conduct primary rough filtration. Wrap a 200-mesh stainless steel filter screen with double-layer sterile gauze to separate the floating foam on the upper layer and the large-particle precipitates settling at the bottom of the container. During this stage, pay attention to the pouring angle of the liquid medicine and slowly pour it along the container wall to avoid disturbing the bottom sediment layer. Transfer the roughly filtered liquid medicine to a clean ceramic cylinder, cover the surface with food-grade filter paper, and let it stand for two hours to adsorb residual suspended matter through capillary action. Then conduct two precision filtrations through a 0.22-micron microporous filter membrane. The liquid medicine collected after the first filtration needs to be refluxed to the storage tank for mixing evenly, and then conduct a second filtration to ensure thorough removal of impurities, thereby completely separating fine impurities.

5. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: After the borneol in Step 5 is dissolved, the dissolved borneol alcohol solution needs to be quickly cooled to 15 - 20°C through a serpentine condenser. 4°C cold water circulates on the outer wall of the condenser to prevent the volatilization of borneol.

6. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: When drying the Phellodendron amurense in Step 1, set the temperature of the dryer to 60°C and continuously dry for 4 hours until the water content is less than 10%.

7. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: When laying the Sanguisorba officinalis granules, Phellodendron amurense coarse powder, and inner bark filaments layer by layer into the tank in Step 3, gently press and level the materials after laying every 5 cm thickness of medicinal materials to ensure that there are no large gaps between the materials. The final filling amount does not exceed 70% of the tank volume. Finally, cover the top of the medicinal materials with a filter screen to prevent the medicinal materials from floating up.

8. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: When grinding the notoginseng powder and the liquid medicine in Step 5, the grinding time needs to be controlled within 15 to 20 minutes, and the grinding environment temperature should be kept below 10°C to prevent the degradation of the active ingredients of notoginseng due to friction-induced temperature rise.

9. The production and processing method of a burn and scald medicine according to claim 1, characterized in that: During the dynamic soaking described in Step 3, the flow rate of the circulation device is set to 5 to 8 liters per minute, and the pressure inside the tank needs to be maintained within the range of 0.1 - 0.3 MPa to enhance the solvent penetration efficiency and shorten the dissolution time of the active ingredients.