Seawater-proof self-adhesive wound dressing capable of rapidly stopping bleeding

Abstract

The invention relates to the technical field of medical materials, in particular to a seawater-proof self-adhesive rapid hemostasis wound dressing which comprises a waterproof breathable layer, and a biological adhesive layer, a buffer layer, a pressure-sensitive fixing layer and a medicine dressing layer are sequentially arranged below the waterproof breathable layer from top to bottom. The waterproof breathable layer, the biological bonding layer, the buffer layer, the pressure-sensitive fixing layer and the medicine dressing layer are all of a porous structure, and the projection areas of the waterproof breathable layer, the biological bonding layer and the pressure-sensitive fixing layer in the vertical direction are equal and are all larger than the projection areas of the buffer layer and the medicine dressing layer in the vertical direction; the medicine dressing layer comprises a medicine dressing and an electrostatic spinning film. By means of the buffer layer, when a wound of a patient is subjected to external force, the wound dressing can disperse part of shear stress, then the situation that the wound of the patient is subjected to secondary damage or the wound dressing falls off is reduced, meanwhile, the medicine dressing layer can be more tightly attached to the wound of the patient due to the addition of the buffer layer, and the wound dressing is more comfortable to use. And the hemostatic effect of the medicine dressing layer is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical materials, and particularly to a wound dressing with seawater-proof self-adhesion and rapid hemostasis. Background Art

[0002] In a marine environment or wading activities, people may encounter various accidental injuries, resulting in wounds. At this time, due to the large amount of strongly irritating salts contained in seawater, when the unhealed wound comes into contact with seawater, it will be stimulated, which may affect the normal wound healing process. At the same time, seawater usually contains a large number of microorganisms such as bacteria, viruses and parasites, and these microorganisms may enter the body through the wound, leading to infection. Therefore, these wounds not only need to stop bleeding in time, but also need to prevent the intrusion of external liquids such as seawater to avoid infection and other complications.

[0003] Although the existing wound dressings can fit the wound to a certain extent and stop bleeding from the wound, they may be difficult to buffer the impact force when subjected to external impact.

[0004] In summary, the problem that the existing wound dressings may be difficult to buffer the impact force when subjected to external impact has become a difficult problem that needs to be solved urgently in this field. Therefore, it is necessary to propose a wound dressing with seawater-proof self-adhesion and rapid hemostasis. Summary of the Invention

[0005] To solve the above problems, the present invention provides a wound dressing with seawater-proof self-adhesion and rapid hemostasis. By adding a buffer layer to absorb external impact force, when the patient's wound is subjected to external force, the wound dressing can disperse part of the shear stress, thereby reducing the occurrence of secondary injury to the patient's wound or the detachment of the wound dressing. At the same time, the addition of the buffer layer enables the drug dressing layer to fit more closely to the patient's wound, improving the hemostasis effect of the drug dressing layer.

[0006] To achieve the above object, the technical solution of the present invention is as follows: A wound dressing with seawater-proof self-adhesion and rapid hemostasis, including a waterproof and breathable layer. Below the waterproof and breathable layer, a biological adhesion layer, a buffer layer, a pressure-sensitive fixation layer and a drug dressing layer are fixedly connected in sequence from top to bottom. The waterproof and breathable layer, the biological adhesion layer, the buffer layer, the pressure-sensitive fixation layer and the drug dressing layer are all porous structures. The projection areas of the waterproof and breathable layer, the biological adhesion layer and the pressure-sensitive fixation layer in the vertical direction are equal and are all larger than the projection areas of the buffer layer and the drug dressing layer in the vertical direction.

[0007] The drug dressing layer includes a drug dressing and an electrospun membrane.

[0008] The technical principle of the above solution is as follows:

[0009] When a patient is injured, the wound dressing is applied to the wound. Under the dual fixation of the bioadhesive layer and the pressure-sensitive fixation layer, the wound dressing is firmly fixed at the patient's wound, enabling the drug dressing layer to be in full contact with the patient's wound, enhancing the hemostatic ability of the drug dressing. During this process, the waterproof and breathable layer maintains the breathability of the patient's wound.

[0010] When the patient's wound is under pressure, the buffer layer buffers the force exerted on the patient's wound.

[0011] The above-mentioned solution has the following beneficial effects:

[0012] 1. In the present invention, by adding a buffer layer to absorb external force impacts, when the patient's wound is under external force, the wound dressing can disperse part of the shear stress, thereby reducing the occurrence of secondary injuries to the patient's wound or the detachment of the wound dressing. At the same time, the addition of the buffer layer enables the drug dressing layer to fit more closely to the patient's wound, improving the hemostatic effect of the drug dressing layer.

[0013] 2. In the present invention, through the design of hierarchical projection, the drug dressing layer can accurately cover the patient's wound, and the waterproof and breathable layer, bioadhesive layer, and pressure-sensitive fixation layer expand the sealing range of the wound dressing, thereby enhancing the edge fixation of the wound dressing.

[0014] 3. In the present invention, through the synergistic effect of the bioadhesive layer and the pressure-sensitive fixation layer, the wound dressing can still be instantaneously adhered in seawater immersion or on the surface of wet skin, sealing the wound surface and resisting water flow impact, improving the adaptability of the wound dressing.

[0015] Furthermore, the waterproof and breathable layer is made of polyurethane; the bioadhesive layer is made of a bioadhesive material, and the bioadhesive material is selected as mussel adhesive protein; the buffer layer is made of a self-healing hydrogel; the pressure-sensitive fixation layer is made of a pressure-sensitive adhesive; and the drug dressing is selected as alginate.

[0016] Beneficial effects: Polyurethane has both hydrophobicity and a microporous structure, effectively blocking the penetration of seawater and preventing wound maceration; mussel adhesive protein will immediately solidify to form an adhesion disc when encountering seawater, having strong bioadhesive properties; the self-healing hydrogel combined with the porous structure can effectively absorb external pressure, disperse stress, and protect the wound from secondary injuries; the low-modulus elastic adhesion provided by the pressure-sensitive adhesive enables it to fit flexibly with the skin, enhancing the edge sealing of the wound dressing and preventing seawater from seeping in; alginate will form a gel matrix after degradation, providing a scaffold for cell migration and promoting tissue regeneration.

[0017] Furthermore, the manufacturing method of the wound dressing is as follows:

[0018] Step 1, Material Pretreatment: Prepare an acetic acid aqueous solution and a dissolution solution. Use chitosan, blue shark type II collagen, polyethylene oxide, polyurethane, alginate, mussel adhesive protein, pressure-sensitive adhesive, and self-healing hydrogel as raw materials. Add the dissolution solution to chitosan and blue shark type II collagen respectively and stir to dissolve, obtaining a chitosan solution and a blue shark type II collagen solution.

[0019] Step 2, Solution Preparation: Add the blue shark type II collagen solution, chitosan solution, and polyethylene oxide to a stirring device, and add the acetic acid aqueous solution into the stirring device. Stir and mix the blue shark type II collagen solution, chitosan solution, polyethylene oxide, and acetic acid aqueous solution for 3 h through the stirring component in the stirring device to obtain an electrospinning solution.

[0020] Step 3, Electrospinning: Perform electrospinning on the obtained electrospinning solution to obtain an electrospun membrane.

[0021] Step 4, Dressing Preparation: Stack and fix polyurethane, mussel adhesive protein, self-healing hydrogel, and pressure-sensitive adhesive in sequence, fix alginate at the bottom of the pressure-sensitive adhesive, and fix the electrospun membrane at the bottom of the alginate to complete the preparation of the wound dressing.

[0022] Step 5, Sterilization Treatment: Perform steam sterilization treatment on the obtained wound dressing.

[0023] Step 6, Quality Inspection: The staff inspects the quality of the wound dressing. After the inspection meets the standards, the wound dressing is packaged.

[0024] Beneficial Effects: The blue shark type II collagen solution, chitosan solution, polyethylene oxide, and acetic acid aqueous solution are mixed evenly by the stirring device, providing a stable and excellent electrospinning solution for electrospinning. At the same time, the electrospun membrane obtained by converting the electrospinning solution using electrospinning technology has a very high specific surface area and porosity, further improving the breathability of the wound.

[0025] Furthermore, in Step 1, the dissolution solution is prepared by mixing deionized water, formic acid, acetic acid, hexafluoroisopropanol, trifluoroacetic acid, acetone, and dimethylformamide.

[0026] Beneficial Effects: As a basic solvent, deionized water can dissolve a variety of substances, providing a basic dissolution environment for chitosan and blue shark type II collagen. The addition of formic acid and acetic acid helps to adjust the pH value of the solution, thereby improving the dissolution performance of chitosan and collagen. At the same time, hexafluoroisopropanol and trifluoroacetic acid have special dissolution properties, which can further ensure the complete dissolution of chitosan and collagen.

[0027] Further, in Step 2, when preparing the electrospinning solution, the mass ratio of Type II blue shark collagen, chitosan, and polyethylene oxide is 1:5:1.

[0028] Beneficial effects: Type II blue shark collagen and chitosan are used as the main materials, and the optimization of their ratio helps to form uniform and continuous nanofibers. Polyethylene oxide, as an additive, can regulate the viscosity of the solution and further improve the spinning effect. The mass ratio of 1:5:1 enables the components in the solution to be evenly dispersed, avoiding the instability of the solution caused by too high or too low local concentration.

[0029] Further, in Step 2, the concentration of the electrospinning solution is inversely proportional to the amount of acetic acid aqueous solution added.

[0030] Beneficial effects: During the electrospinning process, the concentration of the solution directly affects the diameter of the formed fibers. By adjusting the amount of acetic acid aqueous solution added to control the solution concentration, the fiber diameter can be precisely regulated, thus obtaining nanofibers of the required size.

[0031] Further, in Step 5, when steam sterilizing the wound dressing, maintain the steam pressure between 102.97 kPa and 205.8 kPa, the temperature between 121 °C and 132 °C, and continue for 15 - 30 minutes.

[0032] Beneficial effects: High-temperature and high-pressure steam has a strong sterilization ability, which can effectively kill various microorganisms including bacteria, viruses, fungi, and their spores, ensuring the aseptic state of the wound dressing before use. By setting the steam pressure, temperature, and sterilization time, the stability and reliability of the sterilization process can be ensured, reducing the infection risk caused by incomplete sterilization.

[0033] Further, the stirring device includes a controller and a guide frame. A driving member is provided above the guide frame. The controller is used to control the rotation of the output shaft of the driving member. Symmetrically fixed to both sides of the driving member are fixed rods, and the ends of the fixed rods away from the driving member are fixedly connected to the top of the guide frame.

[0034] The bottom of the guiding frame is fixedly connected to a storage cylinder, the bottom of the storage cylinder is fixedly connected to a mixing cylinder, the side wall of the mixing cylinder is communicated with a discharge solenoid valve, and the controller is used to control the opening and closing of the discharge solenoid valve. The inner side wall of the storage cylinder is rotationally matched with a rotating disk, the output shaft of the driving member penetrates through the rotating disk and extends into the mixing cylinder and is fixedly connected to a rotating frame. The bottom of the rotating frame is fixedly connected to a gear ring, the inner side wall of the gear ring is meshed with a first gear ring, the bottom of the first gear ring is coaxially fixedly connected to a second gear ring, the outer side wall of the second gear ring is meshed with a gear, the bottom of the gear is fixedly connected to a fixed column, the bottom of the fixed column is fixedly connected to the inner bottom wall of the mixing cylinder, and a rotating plate is rotationally matched on the fixed column. One end of the rotating plate away from the fixed column is communicated with a blanking solenoid valve and is rotationally matched with the bottom of the second gear ring. The controller is used to control the opening and closing of the blanking solenoid valve.

[0035] The top of the first gear ring is fixedly connected to a blanking cylinder, the top of the blanking cylinder is fixedly connected to the bottom of the rotating disk, and a blanking port is opened on the rotating disk and is located directly above the blanking cylinder. The storage cylinder is communicated with the inside of the mixing cylinder through the blanking cylinder, the first gear ring, the second gear ring and the blanking solenoid valve.

[0036] A mixing assembly for mixing the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution is provided at the bottom of the gear ring.

[0037] Beneficial effects: By controlling the opening and closing of the blanking solenoid valve, the controller can accurately control the flow rate of the solution in the blanking cylinder and achieve blanking on demand. This design helps to flexibly adjust the blanking speed according to the mixing requirements and avoid solution accumulation or over-dilution. At the same time, when the output shaft of the driving member rotates, the blanking position will rotate with the rotation of the output shaft of the driving member, thereby realizing multi-angle blanking of the mixing device and ensuring that the mixing assembly can fully mix the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution.

[0038] Further, the mixing assembly includes a mixing rod fixedly connected to the bottom of the gear ring. A plurality of mixing blades are circumferentially fixedly connected to the lower part of the mixing rod, and fan blades are rotationally matched on the mixing blades.

[0039] Beneficial effects: The combination of the mixing rod, mixing blades and fan blades forms a multi-layer mixing structure. This design can ensure that the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution are fully mixed in the mixing cylinder, avoid mixing dead corners, and improve the uniformity and efficiency of mixing.

[0040] Further, pressure sensors are symmetrically fixedly connected to both side walls of the rotating frame. The controller is used to receive the pressure information sent by the pressure sensors and control the forward and reverse rotation of the output shaft of the driving member based on the pressure information.

[0041] Beneficial effects: Based on the pressure information, the controller can intelligently control the forward and reverse rotation of the output shaft of the driving member. This dynamic adjustment helps to optimize the stirring effect, avoid excessive shearing or agglomeration during the stirring process, and thus ensure the uniformity and stability of the stirring and mixing.

[0042] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is an axonometric schematic diagram of the wound dressing structure for preventing seawater self-adhesion and rapid hemostasis of the present invention.

[0044] Figure 2 It is a schematic flow chart of the manufacturing method of the wound dressing in the wound dressing for preventing seawater self-adhesion and rapid hemostasis of the present invention.

[0045] Figure 3 It is an axonometric schematic diagram of the stirring device in the wound dressing for preventing seawater self-adhesion and rapid hemostasis of the present invention.

[0046] Figure 4 It is an axonometric schematic diagram of the stirring assembly in the wound dressing for preventing seawater self-adhesion and rapid hemostasis of the present invention.

[0047] Figure 5 It is a front sectional schematic diagram of the stirring cylinder in the wound dressing for preventing seawater self-adhesion and rapid hemostasis of the present invention.

[0048] Reference numerals in the accompanying drawings of the specification include: 1. Guide frame; 2. Fixed rod; 3. Storage cylinder; 4. Stirring cylinder; 5. Rotating disk; 6. Rotating frame; 7. Ring gear; 8. First toothed ring; 9. Second toothed ring; 10. Gear; 11. Fixed column; 12. Rotating plate; 13. Feed solenoid valve; 14. Feed cylinder; 15. Stirring rod; 16. Stirring blade; 17. Fan blade; 101. Waterproof and breathable layer; 102. Biological adhesive layer; 103. Buffer layer; 104. Pressure-sensitive fixing layer; 105. Drug dressing layer. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0049] The following is a further detailed description through specific embodiments:

[0050] Example 1:

[0051] As shown in the appendix Figure 1 and Figure 2Shown: A wound dressing for seawater-proof self-adhesive rapid hemostasis, including a waterproof and breathable layer 101 made of polyurethane. Below the waterproof and breathable layer 101, there are successively fixed and adhered from top to bottom a biological adhesion layer 102 made of a biological adhesion material, a buffer layer 103 made of a self-healing hydrogel, a pressure-sensitive fixing layer 104 made of a pressure-sensitive adhesive, and a drug dressing layer 105. The waterproof and breathable layer 101, the biological adhesion layer 102, the buffer layer 103, the pressure-sensitive fixing layer 104, and the drug dressing layer 105 are all porous structures. The projected areas of the waterproof and breathable layer 101, the biological adhesion layer 102, and the pressure-sensitive fixing layer 104 in the vertical direction are equal and are all larger than the projected areas of the buffer layer 103 and the drug dressing layer 105 in the vertical direction.

[0052] The drug dressing layer 105 includes a drug dressing and an electrospun membrane. Among them, the biological adhesion material is selected as mussel adhesive protein, and the drug dressing is selected as alginate.

[0053] The manufacturing method of the wound dressing is as follows:

[0054] Step 1, material pretreatment: Prepare an acetic acid aqueous solution and a dissolution solution. The dissolution solution is prepared by mixing deionized water, formic acid, acetic acid, hexafluoroisopropanol, trifluoroacetic acid, acetone, and dimethylformamide. Use chitosan, blue shark type II collagen, polyethylene oxide, polyurethane, alginate, mussel adhesive protein, pressure-sensitive adhesive, and self-healing hydrogel as raw materials. Add the dissolution solution to chitosan and blue shark type II collagen respectively and stir to dissolve to obtain a chitosan solution and a blue shark type II collagen solution.

[0055] Step 2, solution preparation: Add the blue shark type II collagen solution, the chitosan solution, and polyethylene oxide to a stirring device in a mass ratio of 1:5:1, and add the acetic acid aqueous solution to the stirring device. Stir and mix the blue shark type II collagen solution, the chitosan solution, polyethylene oxide, and the acetic acid aqueous solution for 3 h through the stirring component in the stirring device to obtain an electrospinning solution. The concentration of the electrospinning solution is inversely proportional to the amount of the acetic acid aqueous solution added.

[0056] Step 3, electrospinning: Perform electrospinning on the obtained electrospinning solution to obtain an electrospun membrane.

[0057] Step 4, dressing preparation: Stack and fix polyurethane, mussel adhesive protein, self-healing hydrogel, and pressure-sensitive adhesive in sequence, fix alginate at the bottom of the pressure-sensitive adhesive, and fix the electrospun membrane at the bottom of the alginate to complete the preparation of the wound dressing.

[0058] Step 5, sterilization treatment: Perform steam sterilization treatment on the obtained wound dressing. During the steam sterilization process, keep the steam pressure between 102.97 kPa and 205.8 kPa, the temperature between 121 °C and 132 °C, and continue for 20 minutes.

[0059] Step 6, Quality inspection: The staff inspects the quality of the wound dressing. After the inspection meets the standards, the wound dressing is packaged.

[0060] The specific implementation process is as follows: The staff first prepares an acetic acid aqueous solution and mixes deionized water, formic acid, acetic acid, hexafluoroisopropanol, trifluoroacetic acid, acetone, and dimethylformamide to make a dissolution solution. Subsequently, the staff uses chitosan, blue shark type II collagen, polyethylene oxide, polyurethane, alginate, mussel adhesive protein, pressure-sensitive adhesive, and self-healing hydrogel as raw materials, adds the dissolution solution to chitosan and blue shark type II collagen respectively, and stirs to dissolve them to obtain a chitosan solution and a blue shark type II collagen solution.

[0061] After obtaining the chitosan solution and the blue shark type II collagen solution, the staff adds the blue shark type II collagen solution, the chitosan solution, and polyethylene oxide to the stirring device at a mass ratio of 1:5:1, and at the same time adds the acetic acid aqueous solution to the stirring device. Under the stirring action of the stirring component, they are mixed for 3 hours to obtain an electrospinning solution. The staff adds the acetic acid aqueous solution according to the concentration of the electrospinning solution required. Specifically, the concentration of the electrospinning solution is inversely proportional to the amount of the acetic acid aqueous solution added.

[0062] After obtaining the electrospinning solution, the staff performs electrospinning on the prepared electrospinning solution to obtain an electrospun membrane. Subsequently, the staff uses polyurethane as the waterproof and breathable layer 101, mussel adhesive protein as the biological adhesive layer 102, self-healing hydrogel as the buffer layer 103, and pressure-sensitive adhesive as the pressure-sensitive fixing layer 104, and stacks and fixes them in sequence. At the same time, the alginate and the electrospun membrane are stacked and fixed, and they are used as the drug dressing layer 105. The drug dressing layer 105 is fixed at the bottom of the pressure-sensitive fixing layer 104 to obtain a wound dressing.

[0063] The staff sterilizes the prepared wound dressing by steam. During the steam sterilization, the steam pressure is maintained between 102.97 kPa and 205.8 kPa, and the temperature is between 121 °C and 132 °C for 20 minutes. After the steam sterilization is completed, the staff inspects the quality of the wound dressing. After the inspection meets the standards, the wound dressing is packaged.

[0064] When a patient is injured, the wound dressing is attached to the wound through the bioadhesive layer 102 and the pressure-sensitive fixing layer 104. At this time, the bioadhesive layer 102 cures after contacting seawater to form an adhesion disc, which acts synergistically with the pressure-sensitive fixing layer 104 to ensure firm attachment to the patient's wound. The alginate forms a gel matrix after degradation, providing a scaffold for cell migration and thus promoting tissue regeneration of the patient's wound. At the same time, the waterproof and breathable layer 101 allows the patient's wound to remain breathable and effectively prevents seawater penetration, causing secondary harm to the patient.

[0065] When the patient's wound is under compressive force, the buffer layer 103 will disperse part of the shear stress to protect the patient's wound.

[0066] By adding the buffer layer 103 to absorb external force impacts, when the patient's wound is under external force, the wound dressing can disperse part of the shear stress, thereby reducing the occurrence of secondary injury to the patient's wound or the detachment of the wound dressing. At the same time, the addition of the buffer layer 103 enables the drug dressing layer 105 to fit more closely to the patient's wound, improving the hemostatic effect of the drug dressing layer 105.

[0067] Example 2:

[0068] As shown in Figure 3 、 Figure 4 and Figure 5 shown, the difference from Example 1 is that the stirring device includes a controller and a guide frame 1. A driving member is provided above the guide frame 1. The controller is used to control the rotation of the output shaft of the driving member. Symmetrically, fixing rods 2 are fixedly connected to both sides of the driving member by screws. The ends of the fixing rods 2 away from the driving member are welded to the top of the guide frame 1.

[0069] A storage cylinder 3 is integrally formed at the bottom of the guide frame 1. A stirring cylinder 4 is integrally formed at the bottom of the storage cylinder 3. An outlet solenoid valve is communicated with the side wall of the stirring cylinder 4. The controller is used to control the opening and closing of the outlet solenoid valve. A rotating disk 5 is rotatably fitted to the inner side wall of the storage cylinder 3. The output shaft of the driving member penetrates through the rotating disk 5 and extends into the stirring cylinder 4 and is fixedly connected to a rotating frame 6 by screws. Symmetrically, pressure sensors are fixedly connected to both side walls of the rotating frame 6. The controller is used to receive the pressure information sent by the pressure sensors and control the forward and reverse rotation of the output shaft of the driving member based on the pressure information. In this embodiment, the driving member is a servo motor.

[0070] A gear ring 7 is integrally formed at the bottom of the rotating frame 6. A first toothed ring 8 is engaged with the inner side wall of the gear ring 7. A second toothed ring 9 is coaxially welded to the bottom of the first toothed ring 8. A gear 10 is engaged with the outer side wall of the second toothed ring 9. A fixing column 11 is welded to the bottom of the gear 10. The bottom of the fixing column 11 is fixedly connected to the inner bottom wall of the mixing cylinder 4. A rotating plate 12 is rotatably fitted on the fixing column 11. One end of the rotating plate 12 away from the fixing column 11 is communicated with a blanking solenoid valve 13 and is rotatably fitted with the bottom of the second toothed ring 9. The controller is used to control the opening and closing of the blanking solenoid valve 13.

[0071] A blanking cylinder 14 is welded to the top of the first toothed ring 8. The top of the blanking cylinder 14 is welded to the bottom of the rotating disc 5. A blanking port is formed on the rotating disc 5, and the blanking port is located directly above the blanking cylinder 14. The storage cylinder 3 is communicated with the inside of the mixing cylinder 4 through the blanking cylinder 14, the first toothed ring 8, the second toothed ring 9 and the blanking solenoid valve 13.

[0072] A stirring assembly for stirring the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution is provided at the bottom of the gear ring 7.

[0073] The stirring assembly includes a stirring rod 15 integrally formed at the bottom of the gear ring 7. A plurality of stirring blades 16 are integrally formed in the circumferential direction at the lower part of the stirring rod 15. Fan blades 17 are rotatably fitted on the stirring blades 16.

[0074] The specific implementation process is as follows: The staff puts the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution that need to be stirred and mixed into the storage cylinder 3 through the guiding frame 1. The controller is used to control the rotation of the output shaft of the servo motor and open the blanking solenoid valve 13. At this time, the mixed blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution enter the inside of the mixing cylinder 4 through the blanking cylinder 14, the first toothed ring 8, the second toothed ring 9 and the blanking solenoid valve 13.

[0075] During the rotation of the output shaft of the servo motor, the rotating frame 6 is driven to rotate. The rotating frame 6 drives the gear ring 7 to rotate. The gear ring 7 drives the first toothed ring 8 to rotate. The first toothed ring 8 drives the second toothed ring 9 to rotate. During the rotation of the second toothed ring 9, the rotating plate 12 and the first toothed ring 8 are driven to make a circular motion around the fixing column 11. The first toothed ring 8 drives the blanking cylinder 14 to make a circular motion with it. The blanking cylinder 14 drives the rotating disc 5 to rotate. During this process, since the rotating plate 12 drives the blanking solenoid valve 13 to rotate, the position of the blanking solenoid valve 13 changes, and the position where the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution enter the mixing cylinder 4 also changes accordingly, making the subsequent stirring and mixing more uniform.

[0076] During the rotation of the gear ring 7, the stirring rod 15 is also driven to make a circular motion around the fixed column 11, and the stirring rod 15 successively drives the stirring blades 16 and the fan blades 17 to make circular motions with it. When the fan blades 17 stir the blue shark type II collagen solution, chitosan solution, polyethylene oxide and acetic acid aqueous solution, they will rotate themselves, thereby further enhancing the stirring and mixing effect.

[0077] When the feeding cylinder 14 continuously rotates to one side of the rotating frame 6 and exerts a pressing force on the pressure sensor, the pressure sensor sends pressure information to the controller. After receiving the pressure information, the controller controls the output shaft of the servo motor to reverse. At this time, the feeding cylinder 14 will gradually move away from the side of the rotating frame 6 it approaches, and so on.

[0078] Obviously, the above embodiments are only examples given for clear illustration and not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or variations can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. And the obvious changes or variations derived therefrom are still within the protection scope of the present invention.

Claims

1. A wound dressing for preventing seawater self - adhesion and quickly stopping bleeding, comprising a waterproof and breathable layer (101), characterized in that, Below the waterproof and breathable layer (101), a biological adhesive layer (102), a buffer layer (103), a pressure-sensitive fixing layer (104) and a drug dressing layer (105) are fixedly connected in sequence from top to bottom. The waterproof and breathable layer (101), the biological adhesive layer (102), the buffer layer (103), the pressure-sensitive fixing layer (104) and the drug dressing layer (105) are all porous structures. The projected areas of the waterproof and breathable layer (101), the biological adhesive layer (102) and the pressure-sensitive fixing layer (104) in the vertical direction are equal and are all larger than the projected areas of the buffer layer (103) and the drug dressing layer (105) in the vertical direction; The drug dressing layer (105) includes a drug dressing and an electrospun membrane.

2. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 1, wherein The waterproof and breathable layer (101) is made of polyurethane; the biological adhesive layer (102) is made of a biological adhesive material, and the biological adhesive material is selected as mussel adhesive protein; the buffer layer (103) is made of a self-healing hydrogel; the pressure-sensitive fixing layer (104) is made of a pressure-sensitive adhesive; the drug dressing is selected as alginate.

3. The wound dressing for preventing seawater self-adhesion and quickly stopping bleeding according to claim 2, characterized in that, The manufacturing method of the wound dressing is as follows: Step 1, material pretreatment: Prepare an acetic acid aqueous solution and a dissolution solution. Use chitosan, blue shark type II collagen, polyethylene oxide, polyurethane, alginate, mussel adhesive protein, pressure-sensitive adhesive and self-healing hydrogel as raw materials. Add the dissolution solution to chitosan and blue shark type II collagen respectively and stir to dissolve to obtain a chitosan solution and a blue shark type II collagen solution; Step 2, solution preparation: Add the blue shark type II collagen solution, the chitosan solution and polyethylene oxide to a stirring device, and add the acetic acid aqueous solution to the stirring device. Stir and mix the blue shark type II collagen solution, the chitosan solution, polyethylene oxide and the acetic acid aqueous solution for 3 h through the stirring component in the stirring device to obtain an electrospinning solution; Step 3, electrospinning: Perform electrospinning on the obtained electrospinning solution to obtain an electrospun membrane; Step 4, dressing preparation: Stack and fix polyurethane, mussel adhesive protein, self-healing hydrogel and pressure-sensitive adhesive in sequence, fix alginate at the bottom of the pressure-sensitive adhesive, and fix the electrospun membrane at the bottom of the alginate to complete the preparation of the wound dressing; Step 5, sterilization treatment: Perform steam sterilization treatment on the obtained wound dressing; Step 6, quality inspection: The staff inspects the quality of the wound dressing. After the inspection meets the standards, the wound dressing is packaged.

4. The wound dressing for preventing seawater self-adhesion and rapid hemostasis according to claim 3, characterized in that, In Step 1, the dissolution solution is prepared by mixing deionized water, formic acid, acetic acid, hexafluoroisopropanol, trifluoroacetic acid, acetone and dimethylformamide.

5. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 4, characterized in that, In Step 2, when preparing the electrospinning solution, the mass ratio of blue shark type II collagen, chitosan and polyethylene oxide is 1:5:

1.

6. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 5, characterized in that, In Step 2, the concentration of the electrospinning solution is inversely proportional to the amount of the acetic acid aqueous solution added.

7. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 6, characterized in that, In Step 5, when performing steam sterilization on the wound dressing, keep the steam pressure between 102.97 kPa and 205.8 kPa, the temperature between 121 °C and 132 °C, and continue for 15 - 30 minutes.

8. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 7, characterized in that, The stirring device includes a controller and a guiding frame (1). There is a driving member above the guiding frame (1). The controller is used to control the rotation of the output shaft of the driving member. Fixed rods (2) are symmetrically and fixedly connected to both sides of the driving member. The ends of the fixed rods (2) far from the driving member are fixedly connected to the top of the guiding frame (1). The bottom of the guiding frame (1) is fixedly connected to a storage cylinder (3). The bottom of the storage cylinder (3) is fixedly connected to a stirring cylinder (4). An outlet solenoid valve is communicated with the side wall of the stirring cylinder (4). The controller is used to control the opening and closing of the outlet solenoid valve. A rotating disk (5) is rotationally matched with the inner side wall of the storage cylinder (3). The output shaft of the driving member penetrates through the rotating disk (5) and extends into the stirring cylinder (4) and is fixedly connected to a rotating frame (6). A toothed ring (7) is fixedly connected to the bottom of the rotating frame (6). A first toothed ring (8) is meshed with the inner side wall of the toothed ring (7). A second toothed ring (9) is coaxially fixedly connected to the bottom of the first toothed ring (8). A gear (10) is meshed with the outer side wall of the second toothed ring (9). A fixed column (11) is fixedly connected to the bottom of the gear (10). The bottom of the fixed column (11) is fixedly connected to the inner bottom wall of the stirring cylinder (4). A rotating plate (12) is rotationally matched with the fixed column (11). The end of the rotating plate (12) far from the fixed column (11) is communicated with a blanking solenoid valve (13) and is rotationally matched with the bottom of the second toothed ring (9). The controller is used to control the opening and closing of the blanking solenoid valve (13). A blanking cylinder (14) is fixedly connected to the top of the first toothed ring (8). The top of the blanking cylinder (14) is fixedly connected to the bottom of the rotating disk (5). A blanking port is opened on the rotating disk (5), and the blanking port is directly above the blanking cylinder (14). The storage cylinder (3) is communicated with the inside of the stirring cylinder (4) through the blanking cylinder (14), the first toothed ring (8), the second toothed ring (9) and the blanking solenoid valve (13). A stirring assembly for stirring a blue shark type II collagen solution, a chitosan solution, polyethylene oxide and an acetic acid aqueous solution is provided at the bottom of the toothed ring (7).

9. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 8, characterized in that The stirring assembly includes a stirring rod (15) fixedly connected to the bottom of the toothed ring (7). A plurality of stirring blades (16) are circumferentially fixedly connected to the lower part of the stirring rod (15). Fan blades (17) are rotationally matched with the stirring blades (16).

10. The wound dressing for preventing seawater self-adhesion and rapidly stopping bleeding according to claim 9, wherein, Pressure sensors are symmetrically and fixedly connected to both side walls of the rotating frame (6). The controller is used to receive the pressure information sent by the pressure sensors and control the forward and reverse rotation of the output shaft of the driving member based on the pressure information.

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