Functional food compatibility formula for relieving cancer pain

Abstract

The invention relates to the field of food science and engineering, in particular to a functional food for relieving cancer pain, which is prepared by selecting traditional Chinese medicines for compatibility according to the principles of eliminating blood stasis, eliminating stagnation, dredging qi, inhibiting tumors and boosting and easing pain. The traditional Chinese medicinal materials with good detumescence, stagnation eliminating, stasis dispersing and relieving effects are used, so that tumors and tissues which are inflamed, swollen and blocked due to tumor infiltration, extrusion and damage are gradually decomposed and reduced, and pain is relieved; meanwhile, the living environment of tumor lesion tissues is improved, and tumor development is controlled and relieved; the viability of nervous system cells is improved by applying traditional Chinese medicines for soothing nerves and stabilizing qi; the traditional Chinese medicines for soothing liver and activating collaterals are used to enhance the resistance of nervous system, enhance the body metabolism function and reduce the injury caused by tumors. The medicines are used together to remove stasis, dissipate stagnation, reduce phlegm, remove stasis, activate blood, relieve pain, soothe the liver and calm the nerves, so that the aim of relieving pain is fulfilled.

Description

Technical Field

[0001] The present invention relates to the field of food science and engineering, and is the product of the cross-integration of multiple disciplines and fields such as nutrition, traditional Chinese medicine, physiology, physical medicine, preventive medicine, bioengineering, and food science. Specifically, it is a functional food for relieving cancer pain. Background Art

[0002] Pain is an unpleasant subjective sensation and emotional experience associated with tissue damage or potential damage, and is the fifth vital sign after heart rate, respiration, blood pressure, and body temperature. Among all pains, cancer pain is the most prominent one. Once cancer pain occurs, it often accompanies the patient until the end of life. Therefore, in the treatment of cancer, analgesia and anti-cancer are equally important. Pain causes great harm to the body and mind of cancer patients, and even makes patients lose the will to survive. At present, at least 60% of cancer pain patients in China do not receive effective analgesic treatment and have a poor quality of life. The treatment of cancer pain is the basis and the primary task of palliative care. The causes of cancer pain can be divided into three categories: pain directly caused by tumors, accounting for about 88%; pain caused by cancer treatment, accounting for about 11%; pain indirectly caused by tumors, accounting for about 1%. Clinically, there are also a few cancer patients who may have pain unrelated to tumors. For example, lung cancer patients may have low back and leg pain caused by concurrent lumbar disc herniation. Therefore, the cause of pain in cancer patients must be clearly diagnosed.

[0003] Modern medicine uses only Western medicines for the treatment of cancer pain. Western medicines are organic chemical drugs, inorganic chemical drugs, and biological products. Looking at their instructions, they have chemical names and structural formulas, and the dosage is more precise than that of traditional Chinese medicines, usually measured in milligrams. Most drugs only have the effects of sterilization, antiviral, and nerve regulation inhibition to eliminate and relieve disease symptoms, and it is difficult to regulate and treat the root cause of the disease. Moreover, they have many side effects, and long-term use has adverse effects on liver and kidney functions.

[0004] With the increasing awareness of people's health, the traditional Chinese medicine concept of food therapy has gradually attracted people's attention and favor, and the demand for it is also increasing. Traditional Chinese medicine theory believes that qi stagnation, blood stasis, phlegm dampness, etc. are important factors leading to cancer. The occurrence of cancer pain is mainly caused by cold pathogen stagnation, qi mechanism disorder, blood stasis blockage, phlegm turbidity condensation, heat toxin aggregation, qi and blood deficiency, etc., resulting in the blockage of collaterals or the loss of nourishment of meridians, and then "pain due to obstruction" and "pain due to lack of nourishment". Almost every cancer develops to a certain stage, especially in the late stage, and these two conditions almost always exist.

[0005] The object of the present invention is to provide a functional food for relieving cancer pain, which is formulated by selecting traditional Chinese medicines based on the principles of dissipating stasis and resolving masses, dredging qi movement, inhibiting tumors, and boosting analgesia. With Chinese medicinal materials having good effects of detumescence, mass dissipation, stasis removal, and soothing, the tumors and the tissues that are inflamed, swollen, congested due to tumor infiltration, extrusion, and destruction are gradually resolved and reduced, thereby alleviating pain; at the same time, the living environment of the tumor-lesioned tissues is improved, and the development of the tumor is controlled and alleviated; traditional Chinese medicines for calming the nerves and regulating qi are used to enhance the viability of nerve system cells; traditional Chinese medicines for soothing the liver and activating collaterals are used to enhance the resistance of the nerve system and the body's metabolic function, and reduce the damage caused by the tumor. The combination of various medicines can dissipate stasis and resolve masses, eliminate phlegm and discharge stasis, promote blood circulation and relieve pain, soothe the liver and calm the nerves, thereby achieving the purpose of alleviating pain. Summary of the Invention

[0006] The applicable population of the present invention: patients with advanced cancer pain, especially patients with pain caused by common cancers such as lung cancer, brain cancer, lymphoma, breast cancer, liver cancer, gastric cancer, esophageal cancer, colorectal cancer, cervical cancer, nasopharyngeal cancer, and prostate cancer. At the same time, patients with basic dietary functions.

[0007] Indications of the present invention: (1) Tissue destruction. When cancer tumors invade the pleura, peritoneum or nerves, invade the periosteum or medullary cavity, increasing the pressure and even causing pathological fractures, it will cause pain in patients, such as bone pain caused by bone metastasis and bone tumors; chest pain caused by lung cancer invading the pleura; shoulder and arm pain caused by tumors at the apex of the lung invading the brachial plexus, etc.

[0008] (2) Nerve compression. Expansion of brain tumors causes headache and cranial nerve pain; neck metastasis of nasopharyngeal cancer compresses the brachial plexus or cervical plexus, causing pain in the neck, shoulder, and arm; retroperitoneal tumors compress the lumbar and abdominal nerve plexuses, causing lumbar and abdominal pain; pain caused by nerve tissues being compressed and invaded by tumors.

[0009] (3) Organ obstruction. When hollow organs are blocked by tumors, discomfort and spasms occur, and severe colic occurs when completely blocked, such as in gastric, intestinal, and pancreatic head cancers, etc.; when breast cancer metastasizes to axillary lymph nodes, it compresses the axillary lymph and blood vessels, causing swelling and pain in the affected arm, etc.

[0010] (4) Tissue tension. When primary and liver metastatic tumors grow rapidly, the liver capsule is overstretched and tightened, causing severe distending pain in the right upper abdomen.

[0011] (5) Tumor ulceration. Severe pain caused by non-healing for a long time and infection.

[0012] In order to ensure and improve the effect of relieving pain, the present invention is divided into two parts. One part is for "pain due to obstruction" and is taken between 3 and 5 pm, which is called "tongji"; the other part is for "pain due to lack of nourishment" and is taken between 9 and 10 pm, which is called "rongji". The two parts can be used at the same time (not mixed) or separately. Implementation

[0013] 1. General preparation of the present invention The prescription composition of the general medicine of the present invention is: Honeysuckle 37g Astragalus 37g (Northwest Longxi) Turmeric 17g Piper longum 17g Agkistrodon 7g Patchouli 7g Angelica dahurica 17g (Northwest Southwest) Chicken gizzard 17g Lily 17g (Northwest Lanzhou) Yam 17g Licorice 17g (Northwest Longxi) Yellow mustard 7g Clove 7g Pueraria lobata 7g Ginkgo 17g Reed root 7g Bitter almond 7g Panax notoginseng 17g (Yunnan) Northern Adenophora 17g Dendrobium 17g Chuanbei 17g Houttuynia 7g Tremella 17g Tangerine peel 17g Eucalyptus 7g Burdock root 7g Platycodon 7g Longan meat 17g Moringa seeds 7g Polygonatum 7g Garlic 17g Explanation of the prescription of the laxative: Most cancers are caused by epithelial tissue lesions, and the vast majority of hyperplasias, tumors, cysts, etc. are caused by turbid toxins, phlegm, dampness, blood stasis, and stagnation. If there is no circulation, there will be pain. Therefore, we should make full use of and give full play to the anti-inflammatory, antipyretic, anti-toxic, blood stasis-removing, qi-promoting, collateral-unblocking, yang-supporting, cold-expelling, dampness-removing, pus-discharging, tissue-promoting, blood-activating, analgesic and analgesic functions of the authentic medicinal materials such as honeysuckle, turmeric, angelica, northern adenophora, Panax notoginseng, licorice, piper longum, and platycodon, so as to effectively relieve cancer pain.

[0014] 2. The prescription of the present invention The prescription composition of the prescription of the present invention is: Prunella vulgaris 31g Black Ganoderma lucidum 31g Dandelion 21g Codonopsis pilosula 21g Ginger 21g Ginseng 11g Black wolfberry 21g (Northwest Ningxia) Gastrodia elata 11g Angelica sinensis 5g Mulberry 5g Daidaihua 5g Fennel 5g Folk hand 5g Gardenia 11g Kelp 11g Black snake 5g Purslane 21g Spirulina 31g Sea cucumber 11g Leek seed 5g Coriander 5g Solanum nigrum 11g Zanthoxylum bungeanum 11g Fangjie of the Rong formula: The occurrence of cancer pain is mainly caused by factors such as cold pathogen stagnation, qi stagnation, blood stasis blockage, phlegm turbidity coagulation, heat toxin aggregation, qi and blood deficiency, etc., resulting in the blockage of collaterals or the loss of nourishment of the meridians, being damaged, compressed, blocked, or weakened, and then "if not nourished, there will be pain". Therefore, the anti-inflammatory, antipyretic, anti-toxic, rash-promoting, qi-regulating, collaterals-unblocking, yang-supporting, cold-dispelling, dampness-removing, granulation-promoting, blood-activating, spasm-stopping, and pain-relieving functions of the genuine medicinal materials homologous to medicine and food, such as Prunella vulgaris, Spirulina, Ganoderma atrum, ginger, Codonopsis pilosula, and Lycium barbarum, are fully utilized and exerted to achieve the effect of effectively relieving cancer pain.

[0015] To verify the effect of the present invention, the applicant of the present invention conducted experimental research with the Qingdao Institute of Marine Biomedicine. The following are the results of the experimental research of the present invention: Evaluation report on the effect of relieving cancer pain: Experimental samples Experimental animals: SD rats, male.

[0016] Main reagents: Paclitaxel; Pregabalin.

[0017] Sample 1: Tongfang extract Sample 2: Rongfang extract The sample formula was all provided by Chen Duling and used as the test sample after extraction and processing.

[0018] Test methods

[0019] The SD rats were randomly divided into groups, with 10 rats in each group: (1) Control group, (2) Paclitaxel model group, (3) Paclitaxel + Pregabalin group, (4) Paclitaxel + Pregabalin + Sample 1 group, (5) Paclitaxel + Pregabalin + Sample 2 group.

[0020] The animals in each group were treated as follows: (1) Animals in the control group: Intraperitoneally injected with normal saline solution on the 1st, 3rd, 5th, and 7th days of the experiment, and simultaneously gavaged with the sample.

[0021] (2) Rats in the Paclitaxel model group: Injected with Paclitaxel solution by intraperitoneal injection on the 1st, 3rd, 5th, and 7th days of the experiment.

[0022] (3) Rats in the Paclitaxel + Pregabalin group: The operation was the same as (2), and at the same time, Pregabalin was gavaged every day.

[0023] (4)Groups 4-5 rats: Administer the corresponding dose of the sample for 7 consecutive days (during this period, the rats in Groups 1-3 were given an equal volume of vehicle by gavage). After 7 days, the operation was the same as in (3), and the corresponding dose of the sample was given by gavage every day.

[0024] Observe and record the general status and signs of the animals every day; Record the mechanical hyperalgesia (measurement of PWT value) or thermal hyperalgesia test (measurement of PWL value) of the rats on the 1st, 3rd, 5th, 7th, and 14th days after the first administration.

[0025] Measurement of PWT value: Place the rats in each group in a cage for 20 min to adapt, allowing them to explore and adapt to the environment. Then, use a von Frey filament to vertically prick the plantar surface of the right hind paw of the rat. Start the measurement from 2.0 g and use the up-down method. That is, if there is a response at 2.0 g, such as foot withdrawal, foot shaking, or foot licking behavior, then measure 1.4 g; if there is no response at 2.0 g, then test with 4.0 g, and so on. If there is a response at 2.0 g for the first time, record it as X and conduct a total of 6 times starting from 2.0 g; if there is no response at 2.0 g for the first time, record it as O and count 5 times starting from the first time there is a response.

[0026] Table 1. Effects of different samples combined with pregabalin on PWT value Group Day 1 Day 3 Day 5 Day 7 Day 14 Normal control group 12.09±0.36 12.00±0.44 12.46±0.00 12.46±0.00 12.46±0.00 Paclitaxel model <![CDATA[8.77±1.26 * > <![CDATA[8.43±1.30 * > <![CDATA[8.84±1.24 * > <![CDATA[8.33±1.14 ** > <![CDATA[4.08±1.05 ** > Paclitaxel + Pregabalin group 11.29±0.80 9.29±1.25 10.59±0.96 <![CDATA[11.71±0.47 # > 6.05±1.16 Paclitaxel + Pregabalin + Sample 1 group <![CDATA[13.62±1.09 # > 11.28±0.81 <![CDATA[12.09±0.36 # > <![CDATA[12.31±1.39 # > 7.75±1.24 Paclitaxel + Pregabalin + Sample 2 group 11.40±0.71 10.87±1.00 11.77±0.65 <![CDATA[11.71±0.47 # > <![CDATA[10.24±0.92 ## > Note: *，** Compared with the normal control group, P<0.05, P<0.01. #，## Compared with the model group, P<0.05, P<0.01.

[0027] Under the conditions of this experiment, both Sample 1 and Sample 2 showed certain combined analgesic effects when combined with pregabalin, and Sample 1 had a relatively stronger analgesic effect.

[0028] Experimental animals: Balb / c mice, male.

[0029] Main reagents: 5-fluorouracil (5-Fu); HepG2 cells (human hepatoma cells).

[0030] Sample 1: Tongfang extract Sample 2: Rongfang extract The sample formula was all provided by Chen Dulin and used as the test sample after extraction and processing.

[0031] The mice were randomly divided into a normal control group and a tumor model group, with 10 mice in each group: Normal control group; (2) Model group; (3) 5-Fu + Sample 1 group; (4) 5-Fu + Sample 2 group; (5) 5-Fu group.

[0032] -(5) was the tumor model group. The animals were given the sample by gavage and 5-Fu. The animals in the positive drug group were given 5-Fu. After modeling, the animals in each sample group were intraperitoneally injected with 5-Fu + gavaged with the test sample, and gavaged continuously for 14 days. The body weight of the animals was measured once a week during the experiment. The dose of the test substance gavaged was adjusted according to the body weight. The animals in the positive control group were intraperitoneally injected with 5-Fu. After 14 days, the relevant indicators were detected.

[0033] (1) Observe and record the general status and signs of the animals every day.

[0034] (2) After the experiment, the animals were sacrificed by cervical dislocation. The tumors were dissected and weighed, and the tumor inhibition rate was calculated; the spleen and thymus were taken, the surrounding adipose tissue and connective tissue were stripped, and the blood attached to their surfaces was blotted with filter paper. The masses of the spleen and thymus were weighed using a precision electronic balance, and the spleen and thymus coefficients were calculated according to the following formula.

[0035] Tumor inhibition rate = (average volume of the model group - average volume of the experimental group) / average volume of the model group × 100%; Organ coefficient = organ mass / body weight

[0036] During the experiment, the mental states of the animals in each group were good, and their food intake, water intake, and defecation were normal. No obvious abnormalities were found in the general status and signs of the animals. At the end of the experiment, the body weight of the animals in the model group was significantly lower than that of the normal control group (P < 0.01), and there was no statistical difference in the body weight of the animals in each drug administration group compared with the model group (see Table 1).

[0037] Compared with the model group, the tumor weights of the animals in the positive drug group (5-Fu) and each sample group were significantly or extremely significantly reduced (P < 0.05, P < 0.01). Among them, the thymus coefficient of the animals in sample 1 group was significantly increased (P < 0.05). It shows that sample 1 has a good effect of enhancing the body's immunity and an adjuvant anti-tumor effect.

[0038] Table 1 Tumor weights and organ coefficients of animals Experimental group Body weight Tumor weight (g) Spleen coefficient Thymus coefficient Tumor inhibition rate (%) Control group 45.93±2.70 - 0.30±0.07 0.26±0.03 - Model group <![CDATA[41.06±3.51 ** > 0.029±0.006 <![CDATA[0.24±0.03 ** > <![CDATA[0.21±0.03 ** > - Sample 1 group 39.13±3.50 <![CDATA[0.021±0.009 # > 0.26±0.04 <![CDATA[0.27±0.08 # > 26.1 Sample 2 group 42.92±3.41 <![CDATA[0.022±0.009 # > 0.24±0.05 0.25±0.07 24.1 Positive drug group (5 - Fu) 42.77±3.91 <![CDATA[0.021±0.006 ## > 0.25±0.05 0.20±0.07 26.1 Note: ** Compared with the normal control group, P < 0.05, P < 0.01. #，## Compared with the model group, P < 0.05, P < 0.01.

[0039] Under the conditions of this experiment, the adjuvant effect of sample 1 on the anti-tumor effect of 5-Fu was relatively obvious.

[0040] The above are only examples of this invention patent and are not intended to limit this invention patent. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of this invention patent shall be included within the protection scope of this invention patent.

Claims

1. A functional food for relieving cancer pain, characterized in that It is composed of a promoting agent formula and a nourishing agent formula, both of which are made of traditional Chinese medicine compatibility for removing stasis and dissipating nodules, dredging qi mechanism, inhibiting tumors, and boosting analgesia. The promoting agent formula uses traditional Chinese medicinal materials with good effects of detumescence, dissipating nodules, removing stasis, and soothing, so that the tumors and the tissues inflamed, swollen, and congested caused by tumor infiltration, extrusion, and destruction are gradually resolved and reduced, and the pain is alleviated; at the same time, it improves the living environment of the tumor-lesioned tissues, controls and alleviates the development of tumors; the nourishing agent formula uses traditional Chinese medicine for calming the nerves and stabilizing qi to enhance the viability of nerve system cells; uses traditional Chinese medicine for soothing the liver and activating collaterals to enhance the resistance of the nervous system, enhance the body's metabolic function, and reduce the damage caused by tumors. The combination of various medicines can remove stasis and dissipate nodules, resolve phlegm and discharge stasis, promote blood circulation and relieve pain, soothe the liver and calm the nerves, so as to achieve the purpose of alleviating pain.

2. The functional food according to claim 1, for "pain due to obstruction", is taken at 3 - 5 p.m., which is called the "unblocking agent", and is characterized in that, Its formula is: 37 grams of honeysuckle, 37 grams of astragalus membranaceus (from Longxi in the northwest), 17 grams of turmeric, 17 grams of piper longum, 7 grams of agkistrodon halys, 7 grams of pogostemon cablin, 17 grams of angelica dahurica (from the northwest and southwest), 17 grams of endothelium corneum gigeriae galli, 17 grams of lilium brownii (from Lanzhou in the northwest), 17 grams of Chinese yam, 17 grams of licorice root (from Longxi in the northwest), 7 grams of brassica juncea seeds, 7 grams of cloves, 7 grams of pueraria lobata, 17 grams of ginkgo biloba, 7 grams of phragmites communis, 7 grams of bitter apricot kernels, 17 grams of notoginseng (from Yunnan), 17 grams of glehnia littoralis, 17 grams of dendrobium officinale, 17 grams of fritillaria cirrhosa, 7 grams of houttuynia cordata, 17 grams of tremella fuciformis, 17 grams of dried tangerine peel, 7 grams of eucalyptus, 7 grams of burdock root, 7 grams of platycodon grandiflorum, 17 grams of longan aril, 7 grams of moringa seeds, 7 grams of polygonatum sibiricum, 17 grams of garlic.

3. The functional food according to claim 1, characterized in that, For soothing and strengthening the nervous system against "pain caused by deficiency of nourishment" and enhancing nerve resistance, it is taken at 9-10 pm, and is called the "nourishing agent". Its formula is: 31 grams of prunella vulgaris, 31 grams of ganoderma lucidum, 21 grams of dandelion, 21 grams of codonopsis pilosula, 21 grams of ginger, 11 grams of ginseng, 21 grams of black wolfberry (from Ningxia in the northwest), 11 grams of gastrodia elata, 5 grams of angelica sinensis, 5 grams of mulberry, 5 grams of citrus aurantium var. amara, 5 grams of fennel, 5 grams of fingered citron, 11 grams of gardenia jasminoides, 11 grams of thallus laminariae, 5 grams of zaocys dhumnades, 21 grams of portulaca oleracea, 31 grams of spirulina, 11 grams of sea cucumber, 5 grams of semen allii tuberosi, 5 grams of coriandrum sativum, 11 grams of solanum nigrum, 11 grams of Chinese prickly ash.

4. For the functional food according to claim 1, the two formulas can be used simultaneously (not in a mixed way), and can also be used separately.