Method and system for separating yttrium [90Y] in mother liquor containing strontium [90Sr]

Abstract

The invention relates to the technical field of isotopes, in particular to a method and system for separating yttrium [90Y] in mother liquor containing strontium [90Sr]. The invention provides a method for separating yttrium [90Y] in mother liquor containing strontium [90Sr], which comprises the following steps: S1, adding the mother liquor containing strontium [90Sr] into a resin separation column, leaching with leacheate, collecting the leacheate containing strontium [90Sr], and emptying the liquid in the resin separation column with air; s2, eluting by using an eluent, and collecting the eluent containing yttrium [90Y]; wherein the total volume of the used leacheate is at least 11 times of the volume of the resin separation column. By means of the separation method, separation and recovery of yttrium [90Y] in the strontium [90Sr] mother liquor can be achieved, the recovery rate of strontium [90Sr] can be increased, the recovery rate of strontium [90Sr] can reach 98% or above, and the content of other metal impurities after recovery can be reduced.

Description

Technical Field

[0001] The present invention relates to the field of isotope technology, and particularly relates to a method and a system for separating yttrium 90 Sr] from a mother liquor containing strontium 90 Y]. Background Art

[0002] Yttrium-90 90 Y] is a pure β-radioactive nuclide with a half-life of 64 h. The maximum energy of the β-rays generated by decay can reach 2.28 MeV. The decay daughter nuclide 90Zr of yttrium-90 90 Y] is stable and non-toxic and will not affect the human body. In addition, yttrium-90 90 Y] has good chelating chemical properties and is easily labeled on monoclonal antibodies, microspheres, polypeptides, etc. for internal radiotherapy of cancer. Related radioactive drugs and products prepared from 90Y nuclide include yttrium-90 90 Y]-labeled monoclonal antibodies, yttrium-90 90 Y] microspheres, and yttrium-90 90 Y]-labeled polypeptides, etc., which have broad market application prospects. Obtaining yttrium-90 90 Sr]-yttrium-90 90 Y] from a strontium 90 Sr]-yttrium-90 90 Y] nuclide generator has the advantages of simple and fast operation, unrestricted use by region, etc., and the raw material strontium 235 Sr]-is a fission product of uranium 90 U] and can be obtained from spent fuel after long-term cooling. It is currently the main method for obtaining yttrium-90

[0003] Yttrium-90 90 Y] and strontium-90 90The separation of yttrium and strontium is a challenging task because they have similar chemical properties. Three methods are usually used for separation: 1. Precipitation method: Separation is achieved by taking advantage of the differences in precipitation characteristics of different compounds under specific conditions. One of the elements can be precipitated while the other remains in solution by adding an appropriate precipitant. For example, for certain specific anions, yttrium can be precipitated as a sparingly soluble salt, while strontium remains dissolved under the same conditions. The precipitate is then separated from the solution by filtration and other operations to achieve preliminary separation. However, this method usually requires precise control of reaction conditions, and the separation effect may not be ideal, and it is often necessary to combine other methods for further purification. 2. Ion exchange method: A solution containing yttrium and strontium is passed through an ion exchange column, and the yttrium and strontium ions are adsorbed by the resin. Then, by using different eluents, yttrium and strontium can be selectively eluted from the resin. 3. Solvent extraction: Mix the aqueous solution containing yttrium and strontium with the extractant. Under certain conditions (such as specific pH value, temperature, etc.), yttrium and strontium will be distributed between the organic phase and the aqueous phase according to their affinity with the extractant. However, the ion exchange method is used to separate strontium-90[ 90 Yttrium-90[Sr] in the mother liquor 90 Y] will have strontium-90[ 90 Sr] recovery rate is not high and the impurity content is high. In addition, considering the harm of radionuclides to human body and environment, yttrium-90[ 90 Y] and strontium-90[ 90 The safety of the separation process of Sr] is also an urgent problem to be solved. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a method for separating strontium-containing 90 Sr] in the mother liquor 90 Y] method and system, which can improve strontium [ 90 Sr] recovery rate, so that the recovery rate of strontium [ 90 The recovery rate of Sr] reaches more than 98%, and the content of other metal impurities after recovery can also be reduced.

[0005] To this end, the present invention provides the following technical solutions:

[0006] In a first aspect, the present invention provides, in an optional embodiment, a method for separating strontium-containing 90 Sr] in the mother liquor 90 Y] method, comprising the following steps:

[0007] S1: Containing strontium 90 Sr] mother liquor was added to the resin separation column, eluted with eluent, and the strontium-containing [ 90The eluent of [[Sr]], and then the liquid in the resin separation column is emptied with air;

[0008] S2: Elute with the eluent and collect the eluent containing [[Y]]; 90 Y

[0009] Among them, the total volume of the eluent used is at least 11 times the volume of the resin separation column.

[0010] Preferably, before the total volume of the eluent used reaches 9 times the volume of the resin separation column, the flow rate of the eluent is 0.25 - 0.5 mL / min, and after the total volume of the eluent used reaches 9 times the volume of the resin separation column, the flow rate of the eluent is 0.5 - 0.75 mL / min.

[0011] Preferably, the total volume of the eluent used is at least 5 times the volume of the resin separation column, and the flow rate of the eluent is 0.5 - 0.75 mL / min.

[0012] Preferably, the [[Sr]]-containing 90 Sr 90 mother liquor is added in 5 times; and / or, the volume of the [[Sr]]-containing 90 Sr mother liquor added each time is 1 time the volume of the resin separation column.

[0013] Preferably, in the [[Sr]] mother liquor containing [[Y]] 90 90 Sr 90 Y -5 , the radioactivity ratio of [[Sr]] to [[Y]] is less than 10

[0014] Preferably, before step S1, it further includes the step of acid balancing the resin separation column with the eluent; and / or, the eluent uses a hydrochloric acid solution with a concentration of 8 mol / L; and / or, the eluent uses a hydrochloric acid solution with a concentration of 1 mol / L.

[0015] Furthermore, use the first six-way valve to connect the [[Sr]] mother liquor containing [[Y]], the eluent, the eluate and the resin separation column, and use the second six-way valve to collect the separated liquid, including the following steps: 90 Y 90 Sr

[0016] S1: Retain 0.5 mL of air near the common port C of the first six-way valve;

[0017] S2: Transport the eluent to the resin separation column through the first six-way valve for acid balancing, and then collect the acid-balanced liquid through the second six-way valve;

[0018] S3: Feed the strontium 90 Sr] mother liquor containing yttrium 90 Y] into a resin separation column for separation through the first six-way valve, and then collect the separated liquid through the second six-way valve;

[0019] S4: Feed the eluent into the resin separation column for elution through the first six-way valve, then collect the eluted liquid through the second six-way valve, and then feed air into the resin separation column through the first six-way valve to empty the liquid in the resin separation column;

[0020] S5: Feed the eluant into the resin separation column for elution through the first six-way valve, then collect the eluted liquid through the second six-way valve, and complete the separation of yttrium 90 Y] from the strontium 90 Sr] mother liquor containing yttrium 90 Y].

[0021] In a second aspect, in an optional embodiment of the present invention, a system for separating yttrium 90 Y] from a strontium 90 Sr] mother liquor is provided. The system includes a mother liquor tank, a first elution tank, a second elution tank, a first waste liquid tank, a second waste liquid tank, a first eluant tank, a second eluant tank, a cleaning tank, a first six-way valve, a second six-way valve, a power device, a separation device, and a software control device;

[0022] One end of the power device is connected to the cleaning tank, and the other end is connected to the common port C of the first six-way valve, and is used to transport the liquid in the mother liquor tank, the first elution tank, the first waste liquid tank, the first eluant tank, and the cleaning tank to the separation device;

[0023] The 1# port of the first six-way valve is connected to the first elution tank, the 2# port is connected to the mother liquor tank, the 3# port is connected to the first eluant tank, the 4# port is connected to the first waste liquid tank, the 5# port is connected to air, and the 6# port is connected to the liquid inlet of the separation device;

[0024] The common port C of the second six-way valve is connected to the liquid outlet of the separation device, the 1# port is connected to the second waste liquid tank, and the 2# port is connected to the second elution tank;

[0025] The software control device is signal-connected to the power device, the first six-way valve, and the second six-way valve.

[0026] Preferably, the liquid-contact materials of the first six-way valve and the second six-way valve are selected from one of polychlorotrifluoroethylene or sapphire. The power device is an injection pump; the liquid volume accuracy error of the injection pump is less than 1%. The separation device is a resin separation column; and / or, the liquid in the cleaning tank is deionized water; and / or, the liquid in the first rinsing tank is a 1 mol / L hydrochloric acid solution; and / or, the liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

[0027] In the present invention, the central holes of the first six-way valve and the second six-way valve are common channels, which can be switched by the rotor for multi-channel positions to realize the alternate passage of different solutions through the separation material. The flow channel diameter is 1.2 mm, the volume from port to port is 27.5 μL, the volume of the rotor groove is 5.41 μL, the liquid-contact material is PCTEF or sapphire, the pipeline interface is a 1 / 4-28UNF thread interface, the switching time is less than 4 s / turn, and the maximum driving force is 4 N / m. The designed liquid volume accuracy error of the injection pump is less than 1%, and the liquid volume repeatability error is 0.3% - 0.5%. Different specifications of syringes from 50 μL to 10 mL can be selected according to actual use conditions. The pipeline interface is a 1 / 4-28UNF thread interface, and the rated stroke operation time is 2 s - 12000 s (pure water medium). The hardware that the software control device needs to control includes the power device, the first six-way valve and the second six-way valve, and the hardware used includes a 485 hub and a micro touch screen. The power device, the first six-way valve and the second six-way valve communicate through the 485 hub and the micro touch screen. The upper computer software uses the serial port of the computer to send control commands to the 485 hub, and then the hub distributes the commands to each device, thereby realizing the control of the hardware devices. The sealing material of the upper cover of the separation column is selected as thermoplastic polyurethane elastomer rubber, and the intermediate thread is selected as polyether ether ketone material.

[0028] Compared with the prior art, the present invention has one of the following beneficial effects:

[0029] 1. Through the separation method of the present invention, the separation and recovery of yttrium 90 Y] from the strontium 90 Sr] mother liquor can be realized, and the recovery rate of strontium 90 Sr] can be increased. The recovery rate can reach more than 98%, and the content of other metal impurities after recovery can also be reduced.

[0030] 2. The present invention can realize the separation of strontium 90 Sr] and yttrium 90 Sr] in the strontium 90 Sr] mother liquor containing yttrium 90 Y] with a radioactivity ratio of less than 10 -5 .

[0031] 3. The present invention greatly improves yttrium-9090 Y] and strontium-90 90 During the separation process of 90 Sr], the safety is ensured, avoiding the huge harm caused by radioactive leakage. Brief Description of the Drawings

[0032] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0033] Figure 1 It is the system flowchart of Embodiment 1 of the present invention. Detailed Embodiments

[0034] In order to make the objectives, technical solutions and advantages of the present invention more clear and understandable, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0035] Embodiment 1

[0036] This embodiment provides a system for separating yttrium 90 90 Sr] from the mother liquor containing 90 Y], including a mother liquor tank, a first elution tank, a second elution tank, a first waste liquid tank, a second waste liquid tank, a first elution tank, a second elution tank, a cleaning tank, a first six-way valve, a second six-way valve, a power device, a separation device and a software control device;

[0037] One end of the power device is connected to the cleaning tank, and the other end is connected to the common end C port of the first six-way valve, for transporting the liquids in the mother liquor tank, the first elution tank, the first waste liquid tank, the first elution tank, and the cleaning tank to the separation device; the power device is an injection pump, and the injection pump provides power for driving the liquid of the automatic separation device. In the injection pump, by controlling the rotation of the motor to drive the conveyor belt, the conveyor belt synchronously rotates the lead screw, and the lead screw drives the piston to move up and down. The designed liquid volume accuracy error of the injection pump is less than 1%, and the liquid volume repeatability error is 0.3%-0.5%. Different specifications of injectors from 50 μL to 10 mL can be selected according to actual use conditions. The pipeline interface is a 1 / 4-28 UNF thread interface, and the rated stroke operation time is 2 s-12000 s (pure water medium).

[0038] The 1# port of the first six-way valve is connected to the first elution tank, the 2# port is connected to the mother liquor tank, the 3# port is connected to the first elution tank, the 4# port is connected to the first waste liquid tank, the 5# port is connected to the air, and the 6# port is connected to the liquid inlet of the separation device;

[0039] The common port C of the second six-way valve is connected to the liquid outlet of the separation device, the 1# port is connected to the second waste liquid tank, the 2# port is connected to the second rinsing tank, and the 3# port is connected to the second elution tank;

[0040] The central holes of the first six-way valve and the second six-way valve are common channels, which can be switched by the rotor for multi-channel positions to realize the alternate passage of different solutions through the separation material. The flow channel diameter is 1.2 mm, the volume from port to port is 27.5 μL, the volume of the rotor groove is 5.41 μL, the wetted material is PCTEF or sapphire, the pipeline interface is 1 / 4-28UNF thread interface, the switching time is less than 4 s / circle, and the maximum driving force is 4 N / m. The sealing material of the upper cover of the separation column is selected as thermoplastic polyurethane elastomer rubber, and the middle thread is selected as polyether ether ketone material.

[0041] The software control device is signal-connected to the power device, the first six-way valve, and the second six-way valve. The hardware that the software control device needs to control includes the power device, the first six-way valve, and the second six-way valve. The hardware used includes a 485 hub and a micro touch screen. The power device, the first six-way valve, and the second six-way valve communicate through the 485 hub and the micro touch screen. The host computer software uses the serial port of the computer to send control commands to the 485 hub, and then the hub distributes the commands to each device, thereby realizing the control of the hardware devices.

[0042] The separation device is a resin separation column, and the liquid in the cleaning tank is deionized water; the liquid in the first rinsing tank is a 1 mol / L hydrochloric acid solution; the liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

[0043] Example 2

[0044] This example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is realized by using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5-1.5 mL in the eluent is used as the product liquid.

[0045] Specifically, it includes the following steps:

[0046] S1: Reserve 0.5 mL of air near the common port C of the first six-way valve;

[0047] S2: Draw the rinsing liquid (1 mol / L hydrochloric acid solution) from the first rinsing tank at a rate of 5 mL / min from the 1# port of the first six-way valve, switch the first six-way valve to the 6# port, make the rinsing liquid pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to the 1# port, and discharge the rinsing liquid to the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid balance on the resin;

[0048] S3: Draw 2 mL of strontium 90 Y]-containing mother liquor containing yttrium 90 Sr] from the 2# port of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 2.76×10 -6 ). Switch the first six-way valve to the 6# port, and let the mother liquor pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent, and draw a total of 10 mL of strontium 90 Y]-containing mother liquor containing yttrium 90 Sr] according to step S3;

[0049] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first elution tank from the 1# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, switch the second six-way valve to the 1# port, and let the eluent pass through the resin separation column at a rate of 0.43 mL / min before the total volume of the eluent used reaches 9 mL. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to empty the liquid in the resin separation column;

[0050] S5: Draw 3 mL of eluate (8 mol / L hydrochloric acid solution) from the first elution tank from the 3# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to the 3# port, and discharge the eluate into the second elution tank at a rate of 1 ml / min;

[0051] S6: Draw deionized water from the cleaning tank from the common port C of the first six-way valve at a rate of 5 ml / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0052] Example 3

[0053] This example provides a method for separating strontium-containing90 Yttrium in the Sr mother liquor 90 Method for [Y], which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0054] Specifically, it includes the following steps:

[0055] S1: Reserve 0.5 mL of air near the common port C of the first six - way valve.

[0056] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the first rinsing tank at a rate of 5 mL / min from the 1# port of the first six - way valve. Switch the first six - way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six - way valve to the 1# port, and discharge the eluent to the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid - balancing on the resin.

[0057] S3: Draw 2 mL of strontium 90 Y] - containing 90 Sr] mother liquor (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] and yttrium 90 Y] is 2.44×10 -6 ) from the mother liquor tank at a rate of 0.5 mL / min from the 2# port of the first six - way valve. Switch the first six - way valve to the 6# port, make the mother liquor pass through the resin separation column at a rate of 0.25 mL / min, switch the second six - way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. A total of 10 mL of strontium 90 Y] - containing 90 Sr] mother liquor is drawn according to step S3.

[0058] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first rinsing tank at a rate of 5 mL / min from the 1# port of the first six - way valve. Switch the first six - way valve to the 6# port, switch the second six - way valve to the 1# port. Before the total volume of the used eluent reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the used eluent reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent to the second rinsing tank at a rate of 1 mL / min. Switch the first six - way valve to the 5# port, and use air to empty the liquid in the resin separation column.

[0059] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the 3# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 3# port, and discharge the eluent into the second elution tank at a rate of 1 ml / min;

[0060] S6: Draw deionized water from the common port C of the first six-way valve at a rate of 5 ml / min from the cleaning tank. Switch the first six-way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0061] Example 4

[0062] This example provides a method for separating yttrium 90 Y] from a mother liquor containing strontium 90 Sr]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml of the eluent is used as the product liquid.

[0063] Specifically, it includes the following steps:

[0064] S1: Reserve 0.5 mL of air near the common port C of the first six-way valve;

[0065] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first rinsing tank. Switch the first six-way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port, and discharge the eluent into the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid balance on the resin;

[0066] S3: Draw 2 mL of strontium 90 Sr]-containing mother liquor containing yttrium 90 Y] from the 2# port of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] and yttrium 90 Y] is 2.91×10 -6) Switch the first six-way valve to port 6#. Let the mother liquor pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2#. Drain the solution at a rate of 1 mL / min, collect the effluent, and aspirate a total of 10 mL of the mother liquor containing yttrium 90 Y] and strontium 90 Sr] according to step S3;

[0067] S4: Aspirate 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first rinsing tank at a rate of 5 mL / min from port 1# of the first six-way valve. Switch the first six-way valve to port 6#. Switch the second six-way valve to port 1#. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and drain the eluent into the second rinsing tank at a rate of 1 mL / min. Switch the first six-way valve to port 5#, and use air to empty the liquid in the resin separation column;

[0068] S5: Aspirate 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3# of the first six-way valve. Switch the first six-way valve to port 6#. Let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3#, and drain the eluent into the second elution tank at a rate of 1 mL / min;

[0069] S6: Aspirate deionized water from the cleaning tank at a rate of 5 mL / min from the common port C of the first six-way valve. Switch the first six-way valve to port 6#. Let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1#, and drain the deionized water into the second waste liquid tank at a rate of 1 mL / min.

[0070] Example 5

[0071] This example provides a method for separating yttrium 90 Y] from a mother liquor containing strontium 90 Sr]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0072] Specifically, it includes the following steps:

[0073] S1: Reserve 0.5 mL of air near the common port C of the first six-way valve;

[0074] S2: draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from the 1# port of the first six-way valve, switch the first six-way valve to the 6# port, allow the eluent to pass through the resin separation column at a rate of 0.1 mL / min, switch the second six-way valve to the 1# port, discharge the eluent into the second waste liquid tank at a rate of 1 mL / min, empty the air in the resin separation column, and perform acid balance on the resin;

[0075] S3: Draw 2 mL of yttrium-containing solution from the mother liquid tank at a rate of 0.5 mL / min from the 2# port of the first six-way valve. 90 Y] of Sr[ 90 Sr] mother liquor (strontium [ 90 Sr] content is 0.7g / ml, yttrium [ 90 Y] content is 20μg / ml, hydrochloric acid is 1mol / L, strontium [ 90 Sr] and yttrium [ 90 The radioactivity ratio of Y] is 7.59×10 -7 ), switch the first six-way valve to port 6#, pass the mother solution through the resin separation column at a rate of 0.1 mL / min, switch the second six-way valve to port 2#, discharge the solution at a rate of 1 ml / min, collect the effluent, and absorb the yttrium-containing [ 90 Y] Sr[ 90 Sr] mother solution 10mL;

[0076] S4: 11 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from the 1# port of the first six-way valve, the first six-way valve is switched to the 6# port, the second six-way valve is switched to the 1# port, and before the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min, the first six-way valve is switched to the 5# port, and the liquid in the resin separation column is emptied with air;

[0077] S5: 3 mL of eluent (8 mol / L hydrochloric acid solution) is drawn from the first elution tank at a rate of 5 mL / min from the 3# port of the first six-way valve, the first six-way valve is switched to the 6# port, the eluent is passed through the resin separation column at a rate of 0.1 mL / min, the second six-way valve is switched to the 3# port, and the eluent is discharged into the second elution tank at a rate of 1 ml / min;

[0078] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, allow the eluent to pass through the resin separation column at a rate of 0.1 mL / min, switch the second six-way valve to port 1#, and discharge the deionized water to the second waste liquid tank at a rate of 1 ml / min.

[0079] Example 6

[0080] This example provides a method for separating yttrium 90 Y] from the strontium 90 Sr]-containing mother liquor. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0081] Specifically, it includes the following steps:

[0082] S1: Retain 0.5 mL of air near the common port C of the first six-way valve;

[0083] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6#, allow the eluent to pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to port 1#, and discharge the eluent to the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid balance on the resin;

[0084] S3: Draw 2 mL of strontium 90 Sr]-containing mother liquor containing yttrium 90 Y] from the mother liquor tank at a rate of 0.5 mL / min from port 2 of the first six-way valve (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] and yttrium 90 Y] is 8.78×10 -7 ), switch the first six-way valve to port 6#, allow the mother liquor to pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to port 2#, discharge the solution at a rate of 1 ml / min, collect the effluent, and draw a total of 10 mL of strontium 90 Sr]-containing mother liquor containing yttrium 90 Y] according to step S3;

[0085] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port and the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port and use air to empty the liquid in the resin separation column.

[0086] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the 3# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 3# port and discharge the eluent into the second elution tank at a rate of 1 ml / min.

[0087] S6: Draw deionized water from the common port C of the first six-way valve at a rate of 5 ml / min from the cleaning tank. Switch the first six-way valve to the 6# port and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0088] Example 7

[0089] This example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0090] Specifically, it includes the following steps:

[0091] S1: Reserve 0.5 mL of air near the common port C of the first six-way valve.

[0092] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port and let the eluent pass through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to the 1# port and discharge the eluent into the second waste liquid tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid balance on the resin.

[0093] S3: Draw 2 mL of the mother liquor containing yttrium 90 Y] and strontium 90 Sr] from the 2# port of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 9.48×10 -7 ). Switch the first six-way valve to the 6# port, let the mother liquor pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. A total of 10 mL of the mother liquor containing yttrium 90 Y] and strontium 90 Sr] is drawn according to step S3;

[0094] S4: Draw 11 mL of the eluent (1 mol / L hydrochloric acid solution) from the first elution tank from the 1# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, switch the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.5 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.5 mL / min and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to empty the liquid in the resin separation column;

[0095] S5: Draw 3 mL of the eluate (8 mol / L hydrochloric acid solution) from the first elution tank from the 3# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to the 3# port, and discharge the eluate into the second elution tank at a rate of 1 ml / min;

[0096] S6: Draw deionized water from the cleaning tank from the common port C of the first six-way valve at a rate of 5 ml / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0097] Example 8

[0098] This example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium90 A method for [Y], which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product liquid.

[0099] Specifically, it includes the following steps:

[0100] S1: Reserve 0.5 mL of air near the common port C of the first six - way valve.

[0101] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from the 1# port of the first six - way valve, switch the first six - way valve to the 6# port, make the eluent pass through the resin separation column at a rate of 0.25 mL / min, switch the second six - way valve to the 1# port, discharge the eluent to the second waste liquid tank at a rate of 1 mL / min, evacuate the air in the resin separation column, and perform acid balance on the resin.

[0102] S3: Draw 2 mL of strontium 90 Y] - containing 90 Sr] mother liquor (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 2.76×10 -6 ) from the mother liquor tank at a rate of 0.5 mL / min from the 2# port of the first six - way valve, switch the first six - way valve to the 6# port, make the mother liquor pass through the resin separation column at a rate of 0.25 mL / min, switch the second six - way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. A total of 10 mL of strontium 90 Y] - containing 90 Sr] mother liquor is drawn according to step S3.

[0103] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from the 1# port of the first six - way valve, switch the first six - way valve to the 6# port, switch the second six - way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.25 mL / min. After the total volume of the eluent used reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent to the second elution tank at a rate of 1 mL / min. Switch the first six - way valve to the 5# port, and use air to evacuate the liquid in the resin separation column.

[0104] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the 3# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 3# port, and discharge the eluent into the second elution tank at a rate of 1 ml / min;

[0105] S6: Draw deionized water from the common port C of the first six-way valve at a rate of 5 ml / min from the cleaning tank. Switch the first six-way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0106] Example 9

[0107] This example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0108] The difference between the steps of this example and those of Example 2 lies in Step S4. Step S4 of this comparative example is as follows: Draw 9 mL of eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first rinsing tank. Switch the first six-way valve to the 6# port, switch the second six-way valve to the 1# port, so that the eluent passes through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent into the second rinsing tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to empty the liquid in the resin separation column.

[0109] The remaining steps are the same as those of Example 2.

[0110] Comparative Example 1

[0111] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 2 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0112] Specifically, it includes the following steps:

[0113] S1: Retain 0.5 mL of air near the common port C of the first six-way valve;

[0114] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port, discharge the eluent into the second waste liquid tank at a rate of 1 mL / min, evacuate the air in the resin separation column, and perform acid equilibration on the resin;

[0115] S3: Draw 2 mL of the strontium 90 Sr] mother liquor containing yttrium 90 Y] from the mother liquor tank from the 2# port of the first six-way valve at a rate of 0.5 mL / min (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] and yttrium 90 Y] is 1.36×10 -6 ). Switch the first six-way valve to the 6# port, let the mother liquor pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. A total of 10 mL of the strontium 90 Sr] mother liquor containing yttrium 90 Y] is drawn according to step S3;

[0116] S4: Draw 11 mL of the eluent (1 mol / L hydrochloric acid solution) from the first elution tank from the 1# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, switch the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to evacuate the liquid in the resin separation column;

[0117] S5: Draw 3 mL of the eluent (8 mol / L hydrochloric acid solution) from the first elution tank from the 3# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 3# port, and discharge the eluent into the second elution tank at a rate of 1 ml / min;

[0118] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, allow the eluent to pass through the resin separation column at a rate of 0.25 mL / min, switch the second six-way valve to port 1#, and discharge the deionized water to the second waste liquid tank at a rate of 1 ml / min.

[0119] Comparative Example 2

[0120] This comparative example provides a method for separating yttrium 90 Y] from a mother liquor containing strontium 90 Sr]. This method is implemented using the system of Example 1. The volume of the resin separation column is 2 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0121] Specifically, it includes the following steps:

[0122] S1: Retain 0.5 mL of air near the common port C of the first six-way valve;

[0123] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 1# of the first six-way valve, switch the first six-way valve to port 6#, allow the eluent to pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to port 1#, and discharge the eluent to the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid equilibration on the resin;

[0124] S3: Draw 2 mL of strontium 90 Sr] mother liquor containing yttrium 90 Y] from the mother liquor tank at a rate of 0.5 mL / min from port 2# of the first six-way valve (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 2.91×10 -6 ), switch the first six-way valve to port 6#, allow the mother liquor to pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to port 2#, discharge the solution at a rate of 1 ml / min, collect the effluent, and draw a total of 10 mL of strontium 90 Sr] mother liquor containing yttrium 90 Y] according to step S3;

[0125] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port and the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.5 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.5 mL / min and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port and use air to empty the liquid in the resin separation column.

[0126] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the 3# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, let the eluent pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to the 3# port, and discharge the eluent into the second elution tank at a rate of 1 ml / min.

[0127] S6: Draw deionized water from the common port C of the first six-way valve at a rate of 5 ml / min from the cleaning tank. Switch the first six-way valve to the 6# port, let the eluent pass through the resin separation column at a rate of 0.5 mL / min, switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0128] Comparative Example 3

[0129] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 2 mL, and the 0.5 - 1.5 ml in the eluent is used as the product liquid.

[0130] Specifically, it includes the following steps:

[0131] S1: Reserve 0.5 mL of air near the common port C of the first six-way valve.

[0132] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, let the eluent pass through the resin separation column at a rate of 0.8 mL / min, switch the second six-way valve to the 1# port, discharge the eluent into the second waste liquid tank at a rate of 1 mL / min, empty the air in the resin separation column, and perform acid balance on the resin.

[0133] S3: Draw 2 mL of the mother liquor containing yttrium 90 Y] and strontium 90 Sr] from the 2# port of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 6.21×10 -6 ). Switch the first six-way valve to the 6# port, let the mother liquor pass through the resin separation column at a rate of 0.8 mL / min, switch the second six-way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. Totally draw 10 mL of the mother liquor containing yttrium 90 Y] and strontium 90 Sr] according to step S3;

[0134] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first elution tank from the 1# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, switch the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.8 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.8 mL / min and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to empty the liquid in the resin separation column;

[0135] S5: Draw 3 mL of eluate (8 mol / L hydrochloric acid solution) from the first elution tank from the 3# port of the first six-way valve at a rate of 5 mL / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.8 mL / min, switch the second six-way valve to the 3# port, and discharge the eluate into the second elution tank at a rate of 1 ml / min;

[0136] S6: Draw deionized water from the cleaning tank from the common port C of the first six-way valve at a rate of 5 ml / min. Switch the first six-way valve to the 6# port, let the eluate pass through the resin separation column at a rate of 0.8 mL / min, switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0137] Comparative Example 4

[0138] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium90 A method for [Y], which is implemented using the system of Example 1. The volume of the resin separation column is 2 mL, and the 0.5 - 1.5 mL in the eluent is used as the product solution.

[0139] Specifically, it includes the following steps:

[0140] S1: Reserve 0.5 mL of air near the common port C of the first six - way valve.

[0141] S2: Draw the eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from the 1# port of the first six - way valve. Switch the first six - way valve to the 6# port, so that the eluent passes through the resin separation column at a rate of 0.25 mL / min. Switch the second six - way valve to the 1# port, and discharge the eluent into the second waste liquid tank at a rate of 1 mL / min to empty the air in the resin separation column and perform acid balance on the resin.

[0142] S3: Draw 2 mL of strontium 90 [Y] - containing mother liquor from the mother liquor tank at a rate of 0.5 mL / min from the 2# port of the first six - way valve (the content of strontium 90 [Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 [Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 [Sr] and yttrium 90 [Y] is 2.76×10 90 ). Switch the first six - way valve to the 6# port, make the mother liquor pass through the resin separation column at a rate of 0.25 mL / min, switch the second six - way valve to the 2# port, discharge the solution at a rate of 1 ml / min, collect the effluent. A total of 10 mL of strontium -6 [Y] - containing mother liquor is drawn according to step S3. 90 Y] - containing strontium 90 [Sr]

[0143] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from the 1# port of the first six - way valve. Switch the first six - way valve to the 6# port, switch the second six - way valve to the 1# port. Before the total volume of the used eluent reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the used eluent reaches 9 mL, make the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent into the second elution tank at a rate of 1 mL / min. Switch the first six - way valve to the 5# port, and use air to empty the liquid in the resin separation column.

[0144] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the 3# port of the first six-way valve at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to the 6# port, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 3# port, and discharge the eluent into the second elution tank at a rate of 1 ml / min;

[0145] S6: Draw deionized water from the common port C of the first six-way valve at a rate of 5 ml / min from the cleaning tank. Switch the first six-way valve to the 6# port, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 1# port, and discharge the deionized water into the second waste liquid tank at a rate of 1 ml / min.

[0146] Comparative Example 5

[0147] This comparative example provides a method for separating yttrium 90 Y] from a strontium 90 Sr]-containing mother liquor. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml of the eluent is used as the product liquid.

[0148] The difference between the steps of this comparative example and those of Example 2 lies in step S3. The step S3 of this comparative example is as follows: Draw 10 mL of strontium 90 Sr]-containing mother liquor containing yttrium 90 Y] (the content of strontium 90 Sr] in the mother liquor is 0.7 g / ml, the content of yttrium 90 Y] is 20 μg / ml, hydrochloric acid is 1 mol / L, and the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is 2.76×10 -6 ) from the 2# port of the first six-way valve at a rate of 0.5 mL / min. Switch the first six-way valve to the 6# port, and let the mother liquor pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to the 2# port, and discharge the solution at a rate of 1 ml / min, and collect the effluent.

[0149] All other steps are the same as those of Example 2.

[0150] Comparative Example 6

[0151] This comparative example provides a method for separating yttrium 90 Y] from a strontium 90 Sr]-containing mother liquor. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 ml of the eluent is used as the product liquid.

[0152] The difference between the steps of this comparative example and those of Example 2 lies in that step S4 is different. Step S4 of this comparative example is as follows: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first six-way valve's port 1 at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.2 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent to the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to empty the liquid in the resin separation column;

[0153] The remaining steps are the same as those of Example 2.

[0154] Comparative Example 7

[0155] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product liquid.

[0156] The difference between the steps of this comparative example and those of Example 2 lies in that step S4 is different. Step S4 of this comparative example is as follows: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first six-way valve's port 1 at a rate of 5 mL / min from the first elution tank. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.55 mL / min. After the total volume of the eluent used reaches 9 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent to the second elution tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to empty the liquid in the resin separation column.

[0157] The remaining steps are the same as those of Example 2.

[0158] Comparative Example 8

[0159] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product liquid.

[0160] The difference between the steps of this comparative example and those of Example 2 lies in Step S4. Step S4 of this comparative example is as follows: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first six-way valve's port 1 at a rate of 5 mL / min from the first rinsing tank. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 3 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 3 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and drain the eluent into the second rinsing tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to empty the liquid in the resin separation column.

[0161] All other steps are the same as those of Example 2.

[0162] Comparative Example 9

[0163] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product liquid.

[0164] The difference between the steps of this comparative example and those of Example 2 lies in Step S4. Step S4 of this comparative example is as follows: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first six-way valve's port 1 at a rate of 5 mL / min from the first rinsing tank. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 5 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 5 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and drain the eluent into the second rinsing tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to empty the liquid in the resin separation column.

[0165] All other steps are the same as those of Example 2.

[0166] Comparative Example 10

[0167] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product liquid.

[0168] The difference between the steps of this comparative example and those of Example 2 lies in Step S4. Step S4 of this comparative example is as follows: Draw 22 mL of eluent (1 mol / L hydrochloric acid solution) from the 1# port of the first six-way valve at a rate of 5 mL / min from the first rinsing tank. Switch the first six-way valve to the 6# port and the second six-way valve to the 1# port. Before the total volume of the eluent used reaches 15 mL, let the eluent pass through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 15 mL, let the eluent pass through the resin separation column at a rate of 0.75 mL / min, and discharge the eluent into the second rinsing tank at a rate of 1 mL / min. Switch the first six-way valve to the 5# port, and use air to empty the liquid in the resin separation column.

[0169] The remaining steps are the same as those in Example 2.

[0170] Comparative Example 11

[0171] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0172] The difference between the steps of this comparative example and those of Example 2 lies in Step S1. Step S1 of this comparative example is as follows: Retain 0.75 mL of air near the common port C of the first six-way valve.

[0173] The remaining steps are the same as those in Example 2.

[0174] Comparative Example 12

[0175] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90 Y]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0176] The difference between the steps of this comparative example and those of Example 2 lies in Step S1. Step S1 of this comparative example is as follows: Retain 1.3 mL of air near the common port C of the first six-way valve.

[0177] The remaining steps are the same as those in Example 2.

[0178] Comparative Example 13

[0179] This comparative example provides a method for separating yttrium 90 Sr] from the mother liquor containing strontium 90A method for separating yttrium [[Y]] from a strontium [[Sr]]-containing mother liquor, which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product solution.

[0180] The difference between the steps of this comparative example and those of Example 2 lies in that step S1 is different. Step S1 of this comparative example is: retaining 1.5 mL of air near the common port C of the first six-port valve.

[0181] All other steps are the same as those of Example 2.

[0182] Comparative Example 14

[0183] This comparative example provides a method for separating yttrium 90 Sr] from a mother liquor containing yttrium 90 Y], which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product solution.

[0184] The difference between the steps of this comparative example and those of Example 2 lies in that step S1 is different. Step S1 of this comparative example is: retaining 0.4 mL of air near the common port C of the first six-port valve.

[0185] All other steps are the same as those of Example 2.

[0186] Comparative Example 15

[0187] This comparative example provides a method for separating yttrium 90 Sr] from a mother liquor containing yttrium 90 Y], which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product solution.

[0188] The difference between the steps of this comparative example and those of Example 2 is that the eluent is an 8 mol / L nitric acid solution. All other steps are the same as those of Example 2.

[0189] Comparative Example 16

[0190] This comparative example provides a method for separating yttrium 90 Sr] from a mother liquor containing yttrium 90 Y], which is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL in the eluent is used as the product solution.

[0191] The difference between the steps of this comparative example and those of Example 2 is that the eluent is an 8 mol / L sulfuric acid solution. All other steps are the same as those of Example 2.

[0192] Comparative Example 17

[0193] This comparative example provides a method for separating yttrium 90 Y] from a mother liquor containing strontium 90 Sr]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0194] The difference between the steps of this comparative example and those of Example 2 lies in that the eluent is a 1 mol / L nitric acid solution. The remaining steps are the same as those of Example 2.

[0195] Comparative Example 18

[0196] This comparative example provides a method for separating yttrium 90 Y] from a mother liquor containing strontium 90 Sr]. This method is implemented using the system of Example 1. The volume of the resin separation column is 1 mL, and the 0.5 - 1.5 mL of the eluent is used as the product liquid.

[0197] The difference between the steps of this comparative example and those of Example 2 lies in that the eluent is a 1 mol / L sulfuric acid solution. The remaining steps are the same as those of Example 2.

[0198] Experimental Example

[0199] The content of strontium in the eluent is detected by inductively coupled plasma emission spectrometry. According to the formula: recovery rate of strontium = 1 - (content of strontium 90 Sr] in the eluent / content of strontium 90 Sr] in the strontium mother liquor), the recovery rate of strontium 90 Sr] is calculated. The detection results of strontium 90 Sr] and the recovery rate of strontium 90 Sr] are shown in Table 1.

[0200] Table 1 Detection results of the content of strontium 90 Sr] and the recovery rate of strontium 90 Sr]

[0201]

[0202]

[0203] It can be seen from Table 1 that: strictly following the separation method of the present invention can improve the recovery rate of strontium 90 Sr] in the mother liquor containing strontium 90 Sr].

[0204] The impurity contents of the liquids in the second rinsing tank, the second waste liquid tank, and the second elution tank of Example 2 and Comparative Examples 6-10 were determined. The determination was carried out by inductively coupled plasma emission spectrometry. It was detected that in Example 2, Mg ≤ 6 μg / Ci, Pb ≤ 200 μg / Ci, Cu ≤ 10 μg / Ci, Fe ≤ 10 μg / Ci, Al ≤ 10 μg / Ci, and Zr ≤ 27 μg / Ci. The contents of Fe, Al, and Zr in Comparative Example 6 and Comparative Example 7 were 1000 times those in Example 2. The contents of Mg, Pb, and Cu in Comparative Example 8 were 300 times those in Example 2. The contents of Mg, Pb, and Cu in Comparative Example 9 were 71 times those in Example 2. The contents of Mg, Pb, and Cu in Comparative Example 10 were 210 times those in Example 2.

[0205] Although the principles of the present invention have been described in detail above in connection with the preferred embodiments of the present invention, those skilled in the art should understand that the above embodiments are merely explanations of the illustrative implementation manners of the present invention and do not limit the scope of the present invention. The details in the embodiments do not constitute a limitation on the scope of the present invention. Without departing from the spirit and scope of the present invention, any obvious changes such as equivalent transformations and simple substitutions based on the technical solutions of the present invention fall within the protection scope of the present invention.

Claims

1. A method for separating yttrium 90 Sr] from the mother liquor containing 90 Y], characterized in that It includes the following steps: S1: Add the mother liquor containing strontium 90 Sr] to the resin separation column, wash it with the eluent, collect the eluent containing strontium 90 Sr], and then empty the liquid in the resin separation column with air; S2: Elute with an eluent and collect the eluent containing yttrium 90 Y]; Among them, the total volume of the eluent used is at least 11 times the volume of the resin separation column.

2. The method for separating yttrium 90 Sr] from the mother liquor containing 90 Y] according to claim 1, characterized in that Before the total volume of the eluent used reaches 9 times the volume of the resin separation column, the flow rate of the eluent is 0.25 - 0.5 mL / min. After the total volume of the eluent used reaches 9 times the volume of the resin separation column, the flow rate of the eluent is 0.5 - 0.75 mL / min.

3. The method for separating yttrium 90 Sr] from the mother liquor containing 90 Y] according to claim 1, characterized in that The total volume of the eluent used is at least 9 times the volume of the resin separation column, and the flow rate of the eluent is 0.5 - 0.75 mL / min.

4. The method for separating yttrium 90 Sr] from the mother liquor containing 90 Y] according to claim 1, characterized in that The strontium-containing 90 Sr] mother liquor is added in 5 portions; and / or, The volume of the mother liquor containing strontium 90 Sr] added each time is 1 times the volume of the resin separation column.

5. The method for separating yttrium 90 Y] from the mother liquor containing strontium 90 Sr] according to claim 1, characterized in that In the strontium 90 Y]-containing mother liquor, 90 the radioactivity ratio of strontium 90 Sr] to yttrium 90 Y] is less than 10 -5 .

6. The method according to claim 1 for separating 90 yttrium 90 Y] from the mother liquor containing Before step S1, it also includes the step of acid - balancing the resin separation column with an eluent; and / or, The eluent is an 8 mol / L hydrochloric acid solution; and / or, The eluent is a 1 mol / L hydrochloric acid solution.

7. The method for separating yttrium 90 Sr] from the mother liquor containing 90 Y] according to any one of claims 1-6, characterized in that Connect the mother liquor containing yttrium 90 Y], strontium 90 Sr], eluent, eluate and resin separation column with a first six-way valve, and collect the separated liquid with a second six-way valve, including the following steps: S1: Retain 0.5 mL of air near the common port C of the first six - way valve. S2: Transport the eluent into the resin separation column through the first six - way valve for acid - balancing, and then collect the acid - balanced liquid through the second six - way valve. S3: Transfer the strontium 90 Sr] mother liquor containing yttrium 90 Y] to a resin separation column for separation, and then collect the separated liquid through the second six-way valve; S4: Transport the eluent into the resin separation column through the first six - way valve for elution, then collect the eluted liquid through the second six - way valve, and then transport air into the resin separation column through the first six - way valve to empty the liquid in the resin separation column. S5: Deliver the eluent into the resin separation column through the first six-way valve for elution, and then collect the eluted liquid through the second six-way valve to complete the separation of yttrium 90 Y] from the strontium 90 Sr] mother liquor containing yttrium 90 Y].

8. A system for separating yttrium 90 Sr] from the mother liquor containing 90 Y], characterized in that The system includes a mother liquor tank, a first elution tank, a second elution tank, a first waste liquid tank, a second waste liquid tank, a first elution tank, a second elution tank, a cleaning tank, a first six - way valve, a second six - way valve, a power device, a separation device, and a software control device. One end of the power device is connected to the cleaning tank, and the other end is connected to the common port C of the first six - way valve, and is used to transport the liquids in the mother liquor tank, the first elution tank, the first waste liquid tank, the first elution tank, and the cleaning tank to the separation device. The 1# port of the first six - way valve is connected to the first elution tank, the 2# port is connected to the mother liquor tank, the 3# port is connected to the first elution tank, the 4# port is connected to the first waste liquid tank, the 5# port is connected to air, and the 6# port is connected to the liquid inlet of the separation device. The common port C of the second six - way valve is connected to the liquid outlet of the separation device, the 1# port is connected to the second waste liquid tank, and the 2# port is connected to the second elution tank, and the 3# port is connected to the second elution tank. The software control device is signal - connected to the power device, the first six - way valve, and the second six - way valve.

9. The system for separating yttrium 90 90 Y] from the mother liquor containing strontium 90 The liquid - contacting materials of the first six - way valve and the second six - way valve are selected from one of polychlorotrifluoroethylene or sapphire. Sr] according to claim 8, characterized in that, The power device is an injection pump; the liquid volume accuracy error of the injection pump is less than 1%.

10. The system for separating yttrium 90 Y] from the mother liquor containing strontium 90 Sr] according to claim 8, characterized in that The separation device is a resin separation column; and / or, The liquid in the cleaning tank is deionized water; and / or, The liquid in the first elution tank is a 1 mol / L hydrochloric acid solution; and / or, The liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

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