Glycerin triacetate and preparation method thereof

Abstract

The invention discloses glycerol triacetate and a preparation method thereof, and relates to the technical field of glycerol triacetate, and the preparation method comprises the following steps: stirring and mixing polycitric acid and polycaprolactone according to a ratio to obtain a slow-release polymer matrix, stirring and mixing purified water, ethanol, citric acid, vitamin E and propylene glycol according to a ratio to obtain a composition, and preparing the glycerol triacetate. Stirring and mixing the first-class composition and glycerol triacetate according to a proportion to obtain a second-class composition, and stirring and mixing the second-class mixture and a sustained-release polymer matrix in a container to obtain the glycerol triacetate composition; the attractant can continuously act for a long time, the requirement for frequent replacement is reduced, the use efficiency is improved, the attractant can keep the effect under different environment temperatures and humidity, the attractant is still effective under variable weather conditions, the preparation process of the attractant is optimized by adjusting the stirring speed and the mixing time so as to adapt to a specific use environment, and the attractant has good application prospects. And the optimal emission effect is ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of triacetin, and more specifically, to a triacetin and a preparation method thereof. Background Art

[0002] Triacetin, also known as glyceryl triacetate, is a colorless and odorless oily liquid with good solvent, plasticizer, and humectant properties. Its molecular formula is C9H14O6, and its molecular weight is 218.21. It has a high viscosity at room temperature and can be miscible with most organic solvents such as ethanol, ether, chloroform, and benzene, and can be partially soluble in water. Triacetin has a wide range of applications in multiple industries such as food, spices, printing and dyeing, tobacco, and medicine, and the annual consumption is huge. For example, in the food industry, it can be used as a food additive and a fragrance fixative; in the tobacco industry, it can be used as one of the components of a cigarette harm reduction and efficiency enhancement agent; In the pharmaceutical field, it is also used to prepare drugs for the prevention and treatment of depression, etc. The traditional preparation method mainly uses glycerol and acetic acid as raw materials, and uses inorganic liquid acids such as sulfuric acid and phosphoric acid as catalysts for esterification reactions. However, this process has problems such as environmental pollution, high safety production risks, and low production efficiency. In recent years, with the development of technology, a variety of new catalysts and preparation processes have emerged, such as supported catalysts, heteropolyacid catalysts, solid superacid catalysts, and ionic liquid catalysts. These catalysts have the advantages of high catalytic activity and mild reaction conditions, but still have deficiencies such as uneven distribution of catalyst acid sites, easy carbonization and coking, and easy loss of activity. Therefore, researching and developing a more efficient, environmentally friendly, and low-cost preparation method and application of triacetin has become one of the important topics in the current chemical industry. Summary of the Invention

[0003] To solve the above problems, the present invention provides a triacetin and a preparation method thereof.

[0004] The present invention provides a triacetin, characterized in that the triacetin composition comprises the following components: Ethanol 0.25% to 0.75%, triacetin 93.5% to 94.5%, propylene glycol 0.009% to 0.011%, citric acid 0.1% to 0.15%, vitamin E 0.25% to 0.75%, polycitric acid 0.1% to 0.3%, polycaprolactone 0.075% to 0.125%, and the balance water.

[0005] Preferably, the present invention also provides a triacetin and a preparation method thereof, comprising the following steps: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix; Step 2: Stir and mix purified water, ethanol, citric acid, vitamin E, and propylene glycol in proportion to obtain a first type of composition, and then stir and mix the first type of composition and triacetin in proportion to obtain a second type of composition; Step 3: Stir and mix the second type of mixture and the sustained-release polymer matrix in a container to obtain a triacetin composition; Step 4: Prepare capsules using gelatin, fill the triacetin composition into the interior of the capsules, then process fine holes on the surface of the capsules, and cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation.

[0006] Preferably, the specific working steps of the above Step 1 to Step 3 further include the following: Obtain the external environmental parameter data in the process of the above Step 1 to Step 3 in real time. The external environmental parameter data specifically includes environmental temperature and environmental humidity; Obtain the preset stirring speed, stirring time, set temperature, and set humidity during stirring for each of the above Step 1 to Step 3, and adjust the actual stirring speed and stirring time for each of the above Step 1 to Step 3 in real time according to the externally obtained environmental parameter data in real time.

[0007] Preferably, the specific steps for adjusting the actual stirring speed and stirring time for each of the above Step 1 to Step 3 in real time according to the externally obtained environmental parameter data in real time are as follows: Mark the collected real-time environmental temperature as T, mark the collected real-time environmental humidity as H, mark the set temperature during stirring as r, mark the set humidity during stirring as t, and mark the set stirring speed as X; According to the formula , calculate the adjusted real-time stirring speed ; Mark the set mixing time as E; According to the formula , calculate the adjusted real-time mixing time ; After the stirring in the process of the above Step 1 to Step 3 starts, use the calculated adjusted real-time stirring speed and the adjusted real-time mixing time as the parameters for this stirring.

[0008] Preferably, the specific steps for adjusting the actual stirring speed and stirring time for each of the above Step 1 to Step 3 in real time according to the externally obtained environmental parameter data in real time further include: Obtain the difference F between the real-time ambient temperature and the set temperature during stirring, and obtain the difference J between the real-time ambient humidity and the set humidity during stirring; If the difference F is within ±5% of the set temperature r during stirring, and the difference J is within ±5% of the set humidity t during stirring, then the adjusted real-time stirring speed obtained by calculation and the adjusted real-time mixing time are used as the parameters for this stirring, and the stirring speed and time are adjusted to adapt to the temperature change; If the difference F exceeds ±5% of the set temperature r during stirring, or the difference J exceeds ±5% of the set humidity t during stirring, then the set temperature and set humidity during stirring are used for stirring and mixing.

[0009] Preferably, the specific steps of step four include the following: First, select gelatin as the wall material, dissolve the gelatin solution and pour it into a mold to obtain an initial capsule; Fill the triacetin composition as the core material into the initial capsule to obtain a capsule; Perform an ice bath treatment on the formed capsule; Process fine holes on the surface of the capsule, and finally cover the outside of the fine holes with a tearable plastic film to seal the fine holes, completing the preparation.

[0010] Preferably, the specific steps of processing fine holes on the surface of the capsule are as follows: Determine the number and diameter of the fine holes on the surface of the capsule; Fix the capsule on the processing equipment and process the fine holes according to the determined number and diameter of the fine holes.

[0011] Preferably, the specific steps of determining the number and diameter of the fine holes on the surface of the capsule are as follows: Obtain the average surface area S of the capsule, and calculate according to the formula , where D is the diameter of the capsule; Calculate and obtain the total area A of all fine holes according to the formula , where b is time and E is the ideal release rate; Calculate and obtain the fine hole coverage rate C on the surface of the capsule according to the formula ; Obtain the diameter g of the fine holes based on the fine hole coverage rate C on the surface of the capsule and the average surface area S of the capsule; Calculate and obtain the area of a single fine hole according to the formula ; Calculate and obtain the number of fine holes according to the formula ; .

[0012] Preferably, the specific method for obtaining the pore diameter g based on the pore coverage rate C on the surface of the capsule and the average surface area S of the capsule is as follows: According to the formula , calculate to obtain the pore diameter d, where is a proportionality constant.

[0013] Preferably, the specific steps for covering a tearable plastic film outside the pores for sealing are as follows: Cut the plastic film according to the size and shape of the capsule, and cover the cut plastic film on the surface of the capsule; Use an adhesive to fix the plastic film on the surface of the capsule.

[0014] Beneficial effects: It can generate a strong attraction to mosquitoes and flies, effectively attract target pests, the attractant has long-acting properties, can act continuously for a long time, reduce the need for frequent replacement, improve the use efficiency, the attractant can maintain its effect under different environmental temperatures and humidities, making it still effective under changing climatic conditions, by adjusting the stirring speed and mixing time, the preparation process of the attractant is optimized to adapt to a specific use environment and ensure the best emission effect, adding specific steps to achieve the slow-release effect of the attractant, which not only enhances the attraction effect but also extends the service life of the product and provides more lasting protection. Description of the Drawings

[0015] Figure 1 is a flowchart of the method of the present invention. Detailed Embodiments

[0016] Application scenario: However, due to the characteristics of animal blood and protein in the formula of triacetin, in summer, the main usage season, in order to pursue the attraction to mosquitoes and flies, the content of animal blood in the formula is relatively high and it is more likely to rot and produce peculiar smells. Moreover, in the high-temperature environment in summer, the main usage season, triacetin is more likely to volatilize and dry, thus losing its effect and requiring frequent replacement. Although there is a method of adding a slow-release agent to the triacetin formula, it cannot alleviate the drying caused by water loss during the use of triacetin and will not significantly extend the effective duration.

[0017] As Figure 1 shown: A triacetin, the triacetin composition comprises the following components: ethanol 0.25% to 0.75%, triacetin 93.5% to 94.5%, propylene glycol 0.009% to 0.011%, citric acid 0.1% to 0.15%, vitamin E 0.25% to 0.75%, polycitric acid 0.1% to 0.3%, polycaprolactone 0.075% to 0.125% and the balance of water.

[0018] It should be noted that pure water is used as a solvent to help dissolve and mix other components. Ethanol is an attractant to attract mosquitoes and flies. Triacetin is the main component of the attractant, providing a protein source to attract mosquitoes and flies. Propylene glycol can enhance the attracting effect. Citric acid can adjust the pH value and increase the attracting effect. Vitamin E can increase the attracting effect. Polycitric acid is a sustained-release polymer to control the release rate of the attractant. Polycaprolactone is also a sustained-release polymer, which works together with polycitric acid to provide a more stable sustained-release effect. Gelatin is used as the capsule wall material to encapsulate the attractant and achieve sustained release.

[0019] As an alternative embodiment: The present invention also provides a triacetin and its preparation method, comprising the following steps: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix; Step 2: Stir and mix pure water, ethanol, citric acid, vitamin E and propylene glycol in proportion to obtain a first type of composition, and then stir and mix the first type of composition and triacetin in proportion to obtain a second type of composition; Step 3: Stir and mix the second type of mixture and the sustained-release polymer matrix in a container to obtain a triacetin composition; Step 4: Prepare capsules using gelatin, fill the triacetin composition into the interior of the capsules, then process fine holes on the surface of the capsules, and cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation. It should be noted that processing fine holes on the surface of the capsules and using a tearable plastic film to seal the fine holes outside the fine holes facilitate the release of the internal triacetin composition, and it can be used by simply tearing the plastic film; It also should be noted that by mixing polycitric acid and polycaprolactone to form a sustained-release polymer matrix, this solution effectively controls the release rate of the active ingredients in the attractant, slows down the volatilization and drying processes under high-temperature conditions, thereby significantly extending the service life of the attractant, reducing the replacement frequency, and lowering the maintenance cost; Secondly, using gelatin as the capsule wall material and encapsulating the triacetin composition by complex coacervation method not only enhances the protection of the attractant components, reduces the possibility of odor and spoilage, but also realizes the precise controlled release of the attractant through the fine hole design on the capsule surface, improves the environmental adaptability and usage flexibility of the attractant. In addition, the design of the tearable plastic film outside the capsule provides a convenient activation mechanism for users, enabling the release of the attractant to be controlled according to actual needs.

[0020] As an alternative embodiment: The specific working steps of Steps 1 to 3 further include the following: Obtain the external environmental parameter data in the processes of the first to the third steps in real time. The external environmental parameter data specifically includes environmental temperature and environmental humidity. It should be noted that the external environmental parameter data is the environmental temperature and environmental humidity in the usage scenario of triacetin in the current season and time, and is obtained by real-time collection through a temperature sensor and a humidity sensor. Obtain the preset stirring speed, stirring time, set temperature, and set humidity during stirring for each of the first to the third steps, and adjust the actual stirring speed and stirring time for each of the first to the third steps in real time according to the externally obtained environmental parameter data in real time. In the specific mixing process, environmental parameters such as temperature and humidity will affect the mixing process. These parameters need to be monitored in real time, and the mixing parameters are adjusted according to the data. The mixing time and stirring speed can be dynamically adjusted according to the real-time monitored environmental temperature and humidity to maintain the best mixing effect. This method can improve the efficiency and uniformity of the mixing process and reduce the problem of uneven mixing caused by environmental changes.

[0021] As an optional embodiment: The specific steps for adjusting the actual stirring speed and stirring time for each of the first to the third steps in real time according to the externally obtained environmental parameter data in real time are as follows: Mark the real-time environmental temperature collected as T, mark the real-time environmental humidity collected as H, mark the set temperature during stirring as r, mark the set humidity during stirring as t, and mark the set stirring speed as X. According to the formula , calculate the adjusted real-time stirring speed ; Mark the set mixing time as E; According to the formula , calculate the adjusted real-time mixing time ; After the stirring starts in the processes of the first to the third steps, use the calculated adjusted real-time stirring speed and the adjusted real-time mixing time as the parameters for this stirring. It should be noted that the influence of temperature on the stirring speed and mixing time is an inverse and direct proportional relationship. Since the triacetin composition is generally mixed at a set temperature and humidity, such a preparation method can ensure the best evaporation effect of triacetin. However, in actual use, because the common season is summer, the common usage environment generally has relatively high temperature and humidity, which is quite different from the preparation environment, resulting in too fast evaporation of triacetin in actual use. Therefore, it is necessary to use the current external environmental parameters as a reference to change the temperature and humidity parameters of the triacetin composition during mixing. However, when the temperature and humidity change, the corresponding stirring speed and stirring time also need to be adjusted accordingly. This technical solution can perform stirring and mixing according to the needs under the current external environmental parameters, and try to fit the environmental parameters under the usage conditions, so that the emission of the mixed triacetin is in the best state.

[0022] As an optional embodiment: The specific steps of adjusting the actual stirring speed and stirring time of each of the above steps 1 to 3 in real time according to the environmental parameter data obtained in real time further include: Obtain the difference F between the real-time environmental temperature and the set temperature during stirring, and obtain the difference J between the real-time environmental humidity and the set humidity during stirring; If the difference F is within ±5% of the set temperature r during stirring, and the difference J is within ±5% of the set humidity t during stirring, then the adjusted real-time stirring speed obtained by calculation and the adjusted real-time mixing time are used as the parameters for this stirring, and the stirring speed and time are adjusted to adapt to the temperature change; If the difference F exceeds ±5% of the set temperature r during stirring, or the difference J exceeds ±5% of the set humidity t during stirring, then the set temperature during stirring and the set humidity during stirring are used for stirring and mixing. It should be noted that in special cases, the external environmental parameters are abnormal and exceed the preset parameters during the preparation of the triacetin composition too much, which may affect the mixing process of the triacetin composition. When the comprehensive change of temperature and humidity reaches the degree of any of the above serious deviations, if it is necessary to consider the adjustment or optimization of the mixing process, then the set temperature during stirring and the set humidity during stirring are still used for stirring and mixing.

[0023] As an optional embodiment: The specific steps of step 4 include the following: First, select gelatin as the wall material, dissolve the gelatin solution and pour it into a mold to obtain an initial capsule; Fill the triacetin composition as the core material into the initial capsule to obtain a capsule; Perform an ice bath treatment on the formed capsule to accelerate the coagulation process; Process fine holes on the surface of the capsule, and finally cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation.

[0024] As an optional embodiment: The specific steps of processing the fine holes on the surface of the capsule are as follows: Determine the number and diameter size of the fine holes on the surface of the capsule. It should be noted that in this embodiment, the capsule is spherical in shape, and the fine holes are evenly distributed on the surface of the capsule; Fix the capsule on the processing equipment and perform micropore processing according to the determined number and diameter of the micropores.

[0025] It should be noted that a vibrating rack and the design of the capsule hole positions can be adopted to keep the capsule stable during the processing.

[0026] As an optional embodiment: The specific steps for determining the number and diameter of the micropores on the capsule surface are as follows: Obtain the average surface area S of the capsule and calculate according to the formula , where D is the diameter of the capsule; Calculate and obtain the total area A of all the micropores according to the formula , where b is time and E is the ideal release rate; it should be noted that the ideal release rate refers to the rate at which the drug is released from the preparation under ideal conditions, and multiplying the ideal release rate by time can estimate the total amount of the drug released through the micropores within a specific time period; Calculate and obtain the micropore coverage rate C on the capsule surface according to the formula ; the value of the micropore coverage rate C ranges from 0 to 1. Obtain the diameter g of the micropores based on the micropore coverage rate C on the capsule surface and the average surface area S of the capsule. Calculate and obtain the area of a single micropore according to the formula . Calculate and obtain the number of micropores according to the formula . .

[0027] As an optional embodiment: The specific method for obtaining the diameter g of the micropores based on the micropore coverage rate C on the capsule surface and the average surface area S of the capsule is as follows: Calculate the micropore diameter d according to the formula , where is a proportionality constant.

[0028] The specific method for obtaining the value of is to set the thresholds S1 and S2 of the average surface area S of the capsule. If the average surface area S of the capsule is less than the first threshold, use the first proportionality constant 1 as to calculate the micropore diameter; If the average surface area S of the capsule is greater than or equal to S1 but less than the second threshold S2, use the second proportionality constant 2 as ; If the average surface area S of the capsule is greater than or equal to the second threshold S2, use the third proportionality constant , to calculate the pore diameter; In this way, it can be ensured that the diameter of the pores is proportional to the size of the capsule, thus achieving better control of drug release. Smaller capsules will have smaller pore diameters to prevent rapid drug release; while larger capsules can have larger pore diameters to meet greater drug release requirements. Such a design allows for flexible adjustment of the pore diameter according to the size of different capsules to achieve the desired sustained-release effect; The size of the capsule directly affects its surface area, thereby affecting the rate of drug release. Larger capsules may require larger pores to maintain the drug release rate, while smaller capsules may require smaller pores to control the release rate. The threshold values S1 and S2 of the average surface area S of the capsule are obtained through specific experiments, and it is necessary to obtain the release data of the triacetin composition at different time points through release tests.

[0029] Using the collected data, a drug release curve is plotted; the X-axis (horizontal axis) of the drug release curve represents time, which can be time units such as minutes, hours, or days; The Y-axis of the drug release curve represents the amount or concentration of drug released; According to the release curve, two threshold values S1 and S2 can be determined, and these two threshold values will correspond to different proportionality constants. The threshold value S1 is set at the point where the drug release curve begins to level off, which usually corresponds to the turning point where the drug release rate begins to decline. The threshold value S2 is set in the later stage of the drug release curve, when the drug release is close to complete or reaches a plateau, and this point corresponds to the stage where the drug release rate is very slow or almost zero; The three proportionality constants are also verified and adjusted through actual data. In this embodiment, the values of S1 and S2 are 1 square centimeter and 2 square centimeters, and the corresponding three proportionality constants are 0.034, 0.102, and 0.156 respectively.

[0030] As an alternative embodiment: The specific steps for covering the outside of the pores with a tearable plastic film seal are as follows: According to the size and shape of the capsule, cut out the plastic film and cover the cut plastic film on the surface of the capsule; it should be noted that select a suitable plastic film material, such as polyethylene, polypropylene, or polyester film. These materials have good sealing properties and transparency and are suitable for capsule packaging. Prepare cutting tools, such as scissors, paper cutters, or automated cutting machines, to ensure the accuracy and efficiency of cutting; According to the specific dimensions and shape of the capsule, design and make a corresponding template to ensure that the cut plastic film perfectly matches the capsule; Using the template and cutting tools, cut the plastic film into the required shape and size, ensuring that the edges are smooth and there is no excess material; Gently cover the surface of the capsule with the cut plastic film, ensuring that there are no air bubbles or wrinkles between the film and the capsule; Use an adhesive to fix the plastic film on the surface of the capsule. Select a suitable adhesive, such as hot melt adhesive, pressure sensitive adhesive or water-based adhesive, which should have good adhesion and aging resistance.

[0031] The following is a further description according to specific embodiments: Embodiment

[0032] The percentage of the components of the triacetin composition by mass is: ethanol 0.25%, triacetin 93.5%, propylene glycol 0.009%, citric acid 0.1%, vitamin E 0.25%, polycitric acid 0.1%, polycaprolactone 0.075% and the balance of water; The preparation method of the triacetin composition is as follows: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion according to the preset stirring time and stirring speed to obtain a sustained-release polymer matrix; Step 2: Stir and mix pure water, ethanol, citric acid, vitamin E and propylene glycol in proportion according to the preset stirring time and stirring speed to obtain a first type of composition, and then stir and mix the first type of composition and triacetin in proportion to obtain a second type of composition; Step 3: Stir and mix the second type of mixture and the sustained-release polymer matrix in a container according to the preset stirring time and stirring speed to obtain the triacetin composition, and complete the preparation.

[0033] The temperature for the preparation of the above Steps 1 to 3 is 25 °C, the humidity is 40%RH, the preset stirring time is 15 minutes, and the preset stirring speed is 300 r / min; Embodiment

[0034] The percentage of the components of the triacetin composition by mass is: ethanol 0.5%, triacetin 94%, propylene glycol 0.01%, citric acid 0.125%, vitamin E 0.5%, polycitric acid 0.2%, polycaprolactone 0.01% and the balance of water; The preparation method of the triacetin composition is as follows: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion according to the preset stirring time and stirring speed to obtain a sustained-release polymer matrix; Step 2: Stir and mix pure water, ethanol, citric acid, vitamin E and propylene glycol in proportion according to the preset stirring time and stirring speed to obtain a first type of composition, and then stir and mix the first type of composition and triacetin in proportion to obtain a second type of composition; Step 3: Stir and mix the type-II mixture and the sustained-release polymer matrix in a container according to the preset stirring time and stirring speed to obtain a glyceryl triacetate composition, thus completing the preparation. The temperature and humidity during the preparation of the above Steps 1 to 3 are the same as those in Example 1. The preset stirring time is 15 minutes, and the preset stirring speed is 300 r / min. Example

[0035] The mass percentages of the components of the glyceryl triacetate composition are as follows: ethanol 0.75%, glyceryl triacetate 94.5%, propylene glycol 0.011%, citric acid 0.15%, vitamin E 0.75%, polycitric acid 0.3%, polycaprolactone 0.125%, and the balance water. The preparation method of the glyceryl triacetate composition is as follows: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion according to the preset stirring time and stirring speed to obtain a sustained-release polymer matrix. Step 2: Stir and mix pure water, ethanol, citric acid, vitamin E, and propylene glycol in proportion according to the preset stirring time and stirring speed to obtain a type-I composition, and then stir and mix the type-I composition and glyceryl triacetate in proportion to obtain a type-II composition. Step 3: Stir and mix the type-II mixture and the sustained-release polymer matrix in a container according to the preset stirring time and stirring speed to obtain a glyceryl triacetate composition, thus completing the preparation. The temperature and humidity during the preparation of the above Steps 1 to 3 are the same as those in Example 1. The preset stirring time is 15 minutes, and the preset stirring speed is 300 r / min. Example

[0036] The mass percentages of the components of the glyceryl triacetate composition are as follows: ethanol 0.75%, glyceryl triacetate 94.5%, propylene glycol 0.011%, citric acid 0.15%, vitamin E 0.75%, polycitric acid 0.3%, polycaprolactone 0.125%, and the balance water. Step 1: At the adjusted real-time stirring speed and the adjusted real-time mixing time Stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix. Step 2: At the adjusted real-time stirring speed and the adjusted real-time mixing time Stir and mix pure water, ethanol, citric acid, vitamin E, and propylene glycol in proportion to obtain a type-I composition, and then stir and mix the type-I composition and glyceryl triacetate in proportion to obtain a type-II composition. Step 3: At the adjusted real-time stirring speed and the adjusted real-time mixing time Under these conditions, the binary mixture and the sustained-release polymer matrix are stirred and mixed in a container to obtain a glyceryl triacetate composition, completing the preparation; The temperature in Steps 1 to 3 above is 25 °C, the humidity is 40%RH, the ambient temperature in the current season is 30 °C, which is the usage temperature, and the humidity is 50%RH. Among them, the adjusted real-time stirring speed and the adjusted real-time mixing time are respectively obtained according to; Formula , Formula , where is the stirring speed of 300 r / min in Example 3, T is the usage temperature of glyceryl triacetate of 30 °C, r is the set temperature of 25 °C during stirring in Example 3, t is the set humidity of 40%RH during stirring in Example 3, H is the ambient humidity of glyceryl triacetate, which is 50%RH, and the values are all 0.2; where is the preset stirring time of 15 min, and the values are all 0.2; The stirring time calculated by substituting the data is 12 minutes, and the stirring speed is 241 r / min; Example 5: The mass percentages of the components of the glyceryl triacetate composition are: ethanol 0.75%, glyceryl triacetate 94.5%, propylene glycol 0.011%, citric acid 0.15%, vitamin E 0.75%, polycitric acid 0.3%, polycaprolactone 0.125%, and the balance water; Step 1: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , polycitric acid and polycaprolactone are stirred and mixed in proportion to obtain a sustained-release polymer matrix; Step 2: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , pure water, ethanol, citric acid, vitamin E, and propylene glycol are stirred and mixed in proportion to obtain a first-class composition, and then the first-class composition and glyceryl triacetate are stirred and mixed in proportion to obtain a second-class composition; Step 3: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , the second-class mixture and the sustained-release polymer matrix are stirred and mixed in a container to obtain a glyceryl triacetate composition, completing the preparation; The above-mentioned same temperature is 25 degrees Celsius, the same humidity is 40%RH, the ambient temperature of the current season is 20 degrees Celsius, and the humidity is 30%RH, among which the adjusted real-time stirring speed and the adjusted real-time mixing time are respectively obtained according to; Formula , formula , calculated, where is the stirring speed of 300 r / min in Example 3, T is the usage temperature of triacetin of 20 degrees Celsius, r is the set temperature of 25 degrees Celsius during stirring in Example 3, t is the set humidity of 40%RH during stirring in Example 3, H is the ambient humidity of triacetin, which is 30%RH, and the values are all 0.2; where is the preset stirring time of 15 min, and the values are all 0.2; The stirring time calculated by substituting the data is 19 minutes, and the stirring speed is 378 r / min; Example 6: The mass percentage of the components of the triacetin composition is: ethanol 0.25%, triacetin 93.5%, propylene glycol 0.009%, citric acid 0.1%, vitamin E 0.25%, polycitric acid 0.1%, polycaprolactone 0.075% and the balance of water; when the usage ambient temperature of triacetin is 35 degrees Celsius and the humidity is 60%RH, the preparation is carried out according to the following steps; The preparation method of the triacetin composition is: Step 1: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix; Step 2: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix pure water, ethanol, citric acid, vitamin E and propylene glycol in proportion to obtain a first-class composition, and then stir and mix the first-class composition and triacetin in proportion to obtain a second-class composition; Step 3: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix the second-class mixture and the sustained-release polymer matrix in a container to obtain a triacetin composition, and the preparation is completed; The above-mentioned same temperature is 25 degrees Celsius, and the same humidity is 40%RH, where the adjusted real-time stirring speed and the adjusted real-time mixing time are respectively obtained according to; Formula , Formula , and are calculated, where is the stirring speed of 300 r / min in Example 3, T is the usage temperature of triacetin of 35 degrees Celsius, r is the set temperature of 25 degrees Celsius during stirring in Example 3, t is the set humidity of 40%RH during stirring in Example 3, H is the environmental humidity of triacetin, which is 60%RH, and the values are all 0.2; where is the preset stirring time of 15 min, and the values are all 0.2; The stirring time calculated by substituting the data is 10 minutes, and the stirring speed is 206 r / min; Example 7: The mass percentages of the components of the triacetin composition are: ethanol 0.25%, triacetin 93.5%, propylene glycol 0.009%, citric acid 0.1%, vitamin E 0.25%, polycitric acid 0.1%, polycaprolactone 0.075% and the balance of water; when the usage environmental temperature of triacetin is 35 degrees Celsius and the humidity is 60%RH, it is prepared according to the following steps; The preparation method of the triacetin composition is: Step 1: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix; Step 2: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix pure water, ethanol, citric acid, vitamin E and propylene glycol in proportion to obtain a first-class composition, and then stir and mix the first-class composition and triacetin in proportion to obtain a second-class composition; Step 3: At the same temperature and humidity, at the adjusted real-time stirring speed and the adjusted real-time mixing time , stir and mix the second-class mixture and the sustained-release polymer matrix in a container to obtain a triacetin composition; The above-mentioned same temperature is 25 degrees Celsius, and the same humidity is 40%RH, where the adjusted real-time stirring speed and the adjusted real-time mixing time respectively by according to; formula , formula , calculated, where is the stirring speed of 300 r / min in Example 3, T is the use temperature of triacetin of 35 °C, r is the set temperature of 25 °C during stirring in Example 3, t is the set humidity of 40% RH during stirring in Example 3, H is the environmental humidity of triacetin, which is 60% RH, and the values are all 0.2; where is the preset stirring time of 15 min, and the values are all 0.2; The stirring time calculated by substituting the data is 10 minutes, and the stirring speed is 206 r / min; Step 4: Prepare capsules using gelatin, fill the triacetin composition into the interior of the capsules, then process fine holes on the surface of the capsules, and cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation.

[0037] Among them, Example 1, Example 2, and Example 3 are roughly the same, the difference being the different formula percentages of the triacetin composition. Based on the comparison of Example 1, Example 2, and Example 3, the percentage range of the component quality of the triacetin composition that can meet the requirements can be obtained. The triacetin composition prepared based on the component quality of this triacetin combination has the advantages of strong attraction to mosquitoes and flies and a long effective time; Example 4 and Example 3 are roughly the same, the difference being that although Example 3 is prepared at the same temperature and humidity according to the preset stirring time and stirring speed, in Example 4, the preset temperature is limited to 30 °C and the humidity is 50% RH. By comparison, the performance of triacetin prepared under different environments can be obtained; Example 5 is also roughly the same as Example 3 and Example 4, the difference being that in Example 5, the preset temperature of triacetin is limited to 35 °C and the humidity is 60% RH; through the comparison of Example 4 and Example 5, it can be obtained how the effects of using triacetin compositions under different environmental conditions are different when the preparation conditions of the triacetin composition are different. Because the triacetin composition is generally mixed at the set temperature and humidity, although this preparation method can ensure the best emission effect of triacetin, in the actual use process, since the common season is summer, the common use environment generally has relatively high temperature and humidity, which is quite different from the preparation environment. The comparison between Example 4 and Example 5 can simulate this situation; Example VI is also roughly the same as Example V, except that in Example V, when the ambient temperature for using glycerol triacetate is limited to 35 °C and the humidity is 60%RH, the adjusted real-time stirring speed and the adjusted real-time mixing time are used for preparation; Example VII is also roughly the same as Example VI, except that Example VII adds Step 4, which can extend the usage time and achieve a sustained release effect while ensuring the attracting effect of the glycerol triacetate composition; Performance tests were carried out on the glycerol triacetate compositions prepared in the above examples. The specific test method was to place the glycerol triacetate compositions produced in different examples at the same position and the same height for testing, record the number of mosquitoes and flies attracted per hour, use this value as the attractiveness, and use the time from the start of the test to when the attractiveness is lower than 20% of the average attractiveness as the duration. The test results are shown in the following table: Analysis was carried out on multiple glycerol triacetate compositions prepared according to Examples 1 to 5 above. The attractiveness of the glycerol triacetate compositions prepared in Examples 1 to 3 was greater than 150 per hour, and the duration was longer than 10 hours. Therefore, in the percentage interval of the component quality of the glycerol triacetate composition inferred from Examples 1 to 3, the glycerol triacetate composition prepared in Example 3 can meet the specific usage performance requirements; It should be noted that through the comparison between Example 4 and Example 5, when the difference between the usage environment temperature and the preparation temperature is too large, it will affect the duration of glycerol triacetate; It is worth noting that through the comparison between Example 5 and Example 6, when the difference between the usage environment temperature and the preparation temperature is too large, Example 6 uses the adjusted real-time stirring speed and the adjusted real-time mixing time for mixing, and mixing is carried out according to the current external environmental parameters as needed, so that the duration of glycerol triacetate returns to the normal range; It also needs to be explained that in the steps of Example 7, Step 4 is added, which greatly increases the duration of the glycerol triacetate combination without being overly affected by the attractiveness.

[0038] The above are only the preferred embodiments of the present invention. The protection scope of the present invention is not limited to the above embodiments. All technical solutions falling within the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for those of ordinary skill in the art in this technical field, several improvements and refinements made without departing from the principle of the present invention should also be regarded as within the protection scope of this template.

Claims

1. A triacetin, characterized in that, The triacetin composition comprises the following components: ethanol 0.25% to 0.75%, triacetin 93.5% to 94.5%, propylene glycol 0.009% to 0.011%, citric acid 0.1% to 0.15%, vitamin E 0.25% to 0.75%, polycitric acid 0.1% to 0.3%, polycaprolactone 0.075% to 0.125% and the balance of water.

2. The preparation method of glycerol triacetate according to claim 1, characterized in that, It includes the following steps: Step 1: Stir and mix polycitric acid and polycaprolactone in proportion to obtain a sustained-release polymer matrix; Step 2: Stir and mix purified water, ethanol, citric acid, vitamin E and propylene glycol in proportion to obtain a first-class composition, and then stir and mix the first-class composition and triacetin in proportion to obtain a second-class composition; Step 3: Stir and mix the second-class mixture and the sustained-release polymer matrix in a container to obtain a triacetin composition; Step 4: Prepare capsules using gelatin, fill the triacetin composition into the interior of the capsules, then process fine holes on the surface of the capsules, and cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation.

3. The preparation method of glycerol triacetate according to claim 2, characterized in that, The specific working steps of Steps 1 to 3 further include the following: Obtain the external environment parameter data in the process of Steps 1 to 3 in real time, and the external environment parameter data specifically includes environmental temperature and environmental humidity; Obtain the preset stirring speed, stirring time, set temperature and set humidity during stirring for each of Steps 1 to 3, and adjust the actual stirring speed and stirring time for each of Steps 1 to 3 in real time according to the environmental parameter data obtained in real time.

4. The preparation method of triacetin according to claim 3, wherein, The specific steps of adjusting the actual stirring speed and stirring time for each of Steps 1 to 3 in real time according to the environmental parameter data obtained in real time are as follows: Mark the collected real-time environmental temperature as T, the collected real-time environmental humidity as H, the set temperature during stirring as r, the set humidity during stirring as t, and the set stirring speed as X; According to the formula , the adjusted real-time stirring speed is calculated; Mark the set mixing time as E; According to the formula , the adjusted real-time mixing time is calculated; After the stirring starts during the processes of Step 1 to Step 3, the adjusted real-time stirring speed obtained by calculation and the adjusted real-time mixing time are used as the parameters for this stirring operation.

5. The preparation method of glycerol triacetate according to claim 4, characterized in that, The specific steps of adjusting the actual stirring speed and stirring time for each of Steps 1 to 3 in real time according to the environmental parameter data obtained in real time further include: Obtain the difference F between the real-time environmental temperature and the set temperature during stirring, and obtain the difference J between the real-time environmental humidity and the set humidity during stirring; If the difference F is within ±5% of the set temperature r during stirring, and the difference J is within ±5% of the set humidity t during stirring, then the adjusted real-time stirring speed obtained by calculation and the adjusted real-time mixing time are used as the parameters for this stirring, and the stirring speed and time are adjusted to adapt to temperature changes; If the difference F exceeds ±5% of the set temperature r during stirring, or the difference J exceeds ±5% of the set humidity t during stirring, then use the set temperature and set humidity during stirring for stirring and mixing.

6. The preparation method of glycerol triacetate according to claim 2, characterized in that, The specific steps of Step 4 include the following: First, select gelatin as the wall material, dissolve the gelatin solution and pour it into a mold to obtain initial capsules; Fill the triacetin composition as the core material into the initial capsules to obtain capsules; Perform an ice bath treatment on the formed capsules; Process fine holes on the surface of the capsules, and finally cover the outside of the fine holes with a tearable plastic film to seal the fine holes, thus completing the preparation.

7. A method for preparing triacetin according to claim 6, characterized in that, The specific steps of processing fine holes on the surface of the capsules are: Determine the number and diameter of the micropores on the capsule surface; Fix the capsule on the processing equipment and perform micropore processing according to the determined number and diameter of the micropores.

8. A method for preparing glycerol triacetate according to claim 7, characterized in that, The specific steps for determining the number and diameter of the micropores on the capsule surface are as follows: Obtain the average surface area S of the capsule. According to the formula , calculate and obtain, where D is the diameter of the capsule; According to the formula calculate to obtain the total area A of all pores, where b is the time and E is the ideal release rate; According to the formula , the pore coverage rate C on the surface of the capsule is calculated and obtained; Obtain the diameter g of the micropores based on the micropore coverage rate C on the capsule surface and the average surface area S of the capsule; According to the formula , calculate and obtain the area of a single pore; According to the formula , the number of fine pores is calculated.

9. The preparation method of triacetin according to claim 8, wherein, The specific method for obtaining the diameter g of the micropores based on the micropore coverage rate C on the capsule surface and the average surface area S of the capsule is as follows: According to the formula , the pore diameter d is calculated, where is the proportionality constant.

10. The preparation method of triacetin according to claim 6, characterized in that, The specific steps for covering the outside of the micropores with a tearable plastic film for sealing are as follows: Cut out the plastic film according to the size and shape of the capsule, and cover the cut plastic film on the capsule surface; Use an adhesive to fix the plastic film on the capsule surface.

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