Triclosan antibacterial coating surgical suture and preparation method thereof

Abstract

The invention relates to the technical field of biomedicine, and discloses a triclosan antibacterial coating surgical suture and a preparation method thereof.The suture comprises a base material and a surface antibacterial coating, the base material is selected from one of an absorbable single-strand material, an absorbable multi-strand material, a non-absorbable single-strand material and a non-absorbable multi-strand material, and the surface antibacterial coating is selected from one of an absorbable multi-strand material and a non-absorbable multi-strand material; the antibacterial coating comprises triclosan, a high-molecular carrier and an auxiliary agent, the surface energy of a hydrophobic material is improved, the porosity of a hydrophilic material is increased, the adhesive force between the coating and different base materials is ensured, the base materials can be covered, the uniformity deviation of the coating is avoided, and the coating is free of cracking or falling off through the combination of plasma cleaning and roughening treatment on the surface of the base materials. A synergistic system is formed by triclosan, nano-silver and titanium dioxide, a dual mechanism of targeted destruction of bacterial cell membranes and free radical oxidation is achieved, the antibacterial rate is increased, the MRSA inhibition rate is increased, the degradation rate is regulated and controlled through the polylactic acid-glycolic acid copolymer carrier molecular weight and the lactic acid / glycolic acid proportion, and a curing dynamic formula is combined.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technology, and particularly to a triclosan antibacterial coated surgical suture and a preparation method thereof. Background Art

[0002] With the development of the chemical industry, a series of sutures made of polyamide, polypropylene, and polyglycolide have been developed and widely used due to their excellent mechanical properties and biocompatibility.

[0003] However, the existing technology has the following significant problems: the insufficient adaptability of the antibacterial agent selection and the carrier leads to a short antibacterial cycle or a toxicity risk.

[0004] Therefore, the present invention provides a triclosan antibacterial coated surgical suture and a preparation method thereof. Through the composite carrier formulation design and the coordination of multiple process parameters, the efficient loading of the triclosan coating on 8 types of substrates such as polydioxanone, polyglycolide-lactide copolymer, and polyvinylidene fluoride is realized, and a nano-silver and titanium dioxide synergistic antibacterial system is introduced. The controlled release period is combined with the curing kinetics formula to reduce the infection rate and adapt to the requirements of different clinical scenarios. Summary of the Invention

[0005] (1) Technical Problems to be Solved

[0006] Aiming at the deficiencies of the existing technology, the present invention provides a triclosan antibacterial coated surgical suture and a preparation method thereof, which solve the problems raised in the above background art.

[0007] (2) Technical Solutions

[0008] To achieve the above objectives, the present invention provides the following technical solutions: a triclosan antibacterial coated surgical suture and a preparation method thereof. The suture includes a substrate and a surface antibacterial coating; the substrate is selected from absorbable monofilament materials, absorbable multifilament materials, non-absorbable monofilament materials, and non-absorbable multifilament materials; the antibacterial coating contains triclosan, a polymer carrier, and an auxiliary agent, wherein triclosan accounts for 20% of the total mass of the coating, the polymer carrier accounts for 75%, and the auxiliary agent accounts for 10%; the preparation method includes the following steps:

[0009] S1. Substrate pretreatment: The suture substrate is subjected to plasma cleaning and surface roughening treatment for 20 minutes at a power of 175 W.

[0010] S2. Coating solution preparation: Dissolve triclosan and the polymer carrier in an organic solvent, add the auxiliary agent, and ultrasonically disperse to form a uniform solution with a solution concentration of 30 wt%.

[0011] S3. Coating application: The coating solution is uniformly applied to the surface of the substrate by dip coating, electrospinning and spraying processes, and the coating thickness is 28 μm;

[0012] S4. Curing treatment: The coating is fixed on the surface of the substrate by ultraviolet curing, thermal crosslinking and solvent evaporation. The curing temperature is 80 °C and the time is 1 hour;

[0013] S5. Post-treatment: The coated suture is sterilized and dried. The sterilization methods are ethylene oxide and γ-ray irradiation.

[0014] Preferably, the absorbable monofilament material is selected from polydioxanone;

[0015] The absorbable multifilament material is selected from poly(glycolide-lactide) copolymer;

[0016] The non-absorbable monofilament material is selected from polyvinylidene fluoride;

[0017] The non-absorbable multifilament material is selected from polyethylene terephthalate.

[0018] Preferably, the monofilament diameter of the absorbable monofilament material is 0.2 mm and the breaking strength is greater than 300 MPa; the porosity of the braided wire of the non-absorbable multifilament material is 25% and the surface friction coefficient is less than 0.1.

[0019] Preferably, the polymer carrier is poly(lactic-co-glycolic acid), polyvinylpyrrolidone and chitosan;

[0020] The organic solvent is tetrahydrofuran, dichloromethane and ethyl acetate.

[0021] Preferably, when the polymer carrier is poly(lactic-co-glycolic acid), the molar ratio of lactic acid to glycolic acid is 60:40 and the molecular weight is 110 kDa;

[0022] When the polymer carrier is chitosan, its degree of deacetylation is greater than 80% and the viscosity is 600 mPa·s.

[0023] Preferably, the adjuvant includes a plasticizer, an antioxidant and a pH regulator;

[0024] The plasticizer is triethyl citrate and the addition amount is 5% of the total mass of the coating;

[0025] The antioxidant is vitamin E and propyl gallate, and the addition amount is 1.5% of the total mass of the coating;

[0026] The pH regulator is phosphate buffer and the addition amount is 2% of the total mass of the coating.

[0027] Preferably, the concentration of the coating solution in step S2 is calculated by the following formula:

[0028]

[0029] The meanings of the parameters in the formula are as follows:

[0030] C: mass fraction of the coating solution, controlling the coating loading;

[0031] m1: mass of triclosan, in the range of 0.5 - 15 g;

[0032] m2: mass of the polymer carrier, in the range of 6 - 54 g;

[0033] m3: mass of the organic solvent, in the range of 5 - 100 g.

[0034] Preferably, the thermal crosslinking and curing time in step S4 is determined by the following formula:

[0035]

[0036] The meanings of the parameters in the formula are as follows:

[0037] t: curing time, in the range of 10 seconds - 2 hours;

[0038] A: pre - exponential factor, with a value of 1×10 -6 to 1×10 -3 ;

[0039] E a : reaction activation energy, in the range of 30 - 80 kJ / mol;

[0040] R: gas constant;

[0041] T: curing temperature, in the range of 298 - 393 K.

[0042] Preferably, the coating further includes silver nanoparticles and titanium dioxide photocatalyst, with a particle size of 60 nm, an addition amount of 2% of the total mass of the coating, and forming a synergistic antibacterial system with triclosan.

[0043] Preferably, the γ - ray irradiation dose in step S5 is 21 kGy, the drying treatment is vacuum drying, the temperature is 45 °C, the vacuum degree is less than - 0.08 MPa, and the drying time is 7 hours;

[0044] The antibacterial rate of the final suture is greater than 99.9%, and the slow - release time of the coating in 37 °C physiological saline reaches 18 days.

[0045] (III) Beneficial effects

[0046] Compared with the prior art, the present invention provides a triclosan - antibacterial - coated surgical suture and its preparation method, having the following beneficial effects:

[0047] 1. Broad-spectrum substrate adaptability, solving the problems of coating adhesion and uniformity

[0048] By combining plasma cleaning and roughening treatment on the substrate surface, the surface energy of hydrophobic materials is increased, and the porosity of hydrophilic materials is increased, ensuring the adhesion of the coating to different substrates and covering the substrates.

[0049] 2. High-efficiency synergistic antibacterial, breaking through the limitations of single antibacterial agents

[0050] By forming a synergistic system of triclosan, nano-silver and titanium dioxide, targeting the dual mechanisms of destroying bacterial cell membranes and free radical oxidation, the antibacterial rate is increased, and the inhibition rate against MRSA is increased.

[0051] 3. Precise regulation of the slow-release period, matching the degradation / usage requirements of different sutures

[0052] By regulating the degradation rate through the molecular weight of the poly(lactic-co-glycolic acid) carrier and the ratio of lactic acid / glycolic acid, combined with the curing kinetic formula, the slow release of the absorbable suture coating in physiological saline is realized, synchronized with the substrate degradation period. For non-absorbable sutures, the release rate is controlled by the surface porosity to release drugs and avoid residues.

[0053] 4. Strong process compatibility, avoiding damage to substrate properties

[0054] The combination of low-temperature electrospinning and low-polarity solvents retains the breaking strength of heat-sensitive materials. In the spraying process, the atomization pressure and the receiving distance cooperate to ensure the coating coverage inside the pores of multi-strand braided wires.

[0055] 5. High safety and excellent biocompatibility

[0056] The addition of triclosan loading, nano-silver and pH regulator enables cell survival, and gamma-ray irradiation sterilization does not damage the chemical structure of the coating.

[0057] 6. High feasibility of industrial production

[0058] The coating solution concentration formula and the curing parameter formula provide a quantitative production standard, the coating thickness and antibacterial rate fluctuations between batches, the qualified rate of pilot production, and the cost compared with traditional silver ion coatings. Description of the drawings

[0059] Figure 1 It is a schematic diagram of the overall system framework of the present invention. Detailed implementation manners

[0060] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0061] Please refer to Figure 1 , a triclosan antibacterial coating surgical suture and its preparation method. The suture includes a substrate and a surface antibacterial coating; the substrate is selected from one of absorbable monofilament materials, absorbable multifilament materials, non-absorbable monofilament materials, and non-absorbable multifilament materials; the antibacterial coating contains triclosan, a polymer carrier, and an adjuvant, wherein triclosan accounts for 20% of the total mass of the coating, the polymer carrier accounts for 75%, and the adjuvant accounts for 10%; the preparation method includes the following steps:

[0062] S1. Substrate pretreatment: The suture substrate is subjected to plasma cleaning and surface roughening treatment for 20 minutes at a power of 175 W;

[0063] S2. Coating solution preparation: Dissolve triclosan and the polymer carrier in an organic solvent, add the adjuvant, and ultrasonically disperse to form a uniform solution with a solution concentration of 30 wt%;

[0064] S3. Coating application: The coating solution is uniformly applied to the surface of the substrate by dip coating, electrospinning, and spraying processes, and the coating thickness is 28 μm;

[0065] S4. Curing treatment: The coating is fixed on the surface of the substrate by ultraviolet curing, thermal crosslinking, and solvent evaporation. The curing temperature is 80 °C and the time is 1 hour;

[0066] S5. Post-treatment: The coated suture is sterilized and dried, and the sterilization methods are ethylene oxide and γ-ray irradiation;

[0067] The absorbable monofilament material is selected from polydioxanone;

[0068] The absorbable multifilament material is selected from poly (glycolide-lactide) copolymer;

[0069] The non-absorbable monofilament material is selected from polyvinylidene fluoride;

[0070] The non-absorbable multifilament material is selected from polyethylene terephthalate;

[0071] The monofilament diameter of the absorbable monofilament material is 0.2 mm, and the breaking strength is greater than 300 MPa; the porosity of the braided wire of the non-absorbable multifilament material is 25%, and the surface friction coefficient is less than 0.1;

[0072] The polymer carriers are poly(lactic-co-glycolic acid), polyvinylpyrrolidone and chitosan;

[0073] The organic solvents were tetrahydrofuran, dichloromethane, and ethyl acetate;

[0074] When the polymer carrier is poly(lactic acid-glycolic acid) copolymer, the molar ratio of lactic acid to glycolic acid is 60:40, and the molecular weight is 110 kDa;

[0075] When the polymer carrier is chitosan, its deacetylation degree is greater than 80% and its viscosity is 600 mPa·s;

[0076] Auxiliary agents include plasticizers, antioxidants and pH adjusters;

[0077] The plasticizer is triethyl citrate, and the addition amount is 5% of the total mass of the coating;

[0078] The antioxidants are vitamin E and propyl gallate, and the added amount is 1.5% of the total mass of the coating;

[0079] The pH regulator is a phosphate buffer, and the addition amount is 2% of the total mass of the coating;

[0080] The concentration of the coating solution in step S2 is calculated by the following formula:

[0081]

[0082] The meaning of each parameter in the formula is:

[0083] C: mass fraction of coating solution, controlling coating loading;

[0084] m1: ≡ the mass of chloranil, ranging from 0.5 to 15 g;

[0085] m2: mass of the polymer carrier, ranging from 6 to 54 g;

[0086] m3: mass of organic solvent, range 5-100g;

[0087] The thermal cross-linking curing time in step S4 is determined by the following formula:

[0088]

[0089] The meaning of each parameter in the formula is:

[0090] t: curing time, ranging from 10 seconds to 2 hours;

[0091] A: pre-exponential factor, value is 1×10 -6 to 1×10 -3 ;

[0092] E a: Reaction activation energy, in the range of 30 - 80 kJ / mol;

[0093] R: Gas constant;

[0094] T: Curing temperature, in the range of 298 - 393 K;

[0095] The coating also includes silver nanoparticles and titanium dioxide photocatalyst, with a particle size of 60 nm, an addition amount of 2% of the total mass of the coating, and forms a synergistic antibacterial system with triclosan;

[0096] In step S5, the γ-ray irradiation dose is 21 kGy, the drying treatment is vacuum drying, the temperature is 45 °C, the vacuum degree is less than -0.08 MPa, and the drying time is 7 hours;

[0097] The antibacterial rate of the final suture is greater than 99.9%, and the sustained release time of the coating in 37 °C physiological saline reaches 18 days.

[0098] Example 1: Preparation of triclosan antibacterial coating for PDO monofilament absorbable suture

[0099] Substrate: Polydioxanone monofilament, diameter 0.2 mm, breaking strength 350 MPa.

[0100] Preparation steps:

[0101] 1. Substrate pretreatment:

[0102] Plasma cleaning: Power 200 W, time 15 minutes, to make the oxygen element content on the PDO surface 17%;

[0103] Surface roughening: Etch with 30% glycolic acid solution for 5 minutes, surface roughness Ra 0.8 μm;

[0104] 2. Coating solution preparation:

[0105] Formulation: 8 g of triclosan, 28 g of poly(lactic-co-glycolic acid), 2 g of triethyl citrate, 0.8 g of silver nanoparticles, 1.2 g of phosphate buffer;

[0106] Solvent: 60 g of dichloromethane, ultrasonic dispersion to a solution viscosity of 450 mPa·s.

[0107] 3. Coating application:

[0108] Electrospinning: Voltage 20 kV, spinning solution flow rate 2 mL / h, receiving distance 15 cm, environmental humidity 30%, coating thickness 26 μm.

[0109] 4. Curing treatment:

[0110] UV curing: Wavelength 365 nm, irradiation dose 1500 mJ / cm 2, Curing time: 30 seconds.

[0111] 5. Post-treatment:

[0112] Sterilization: Irradiated with γ-rays at 25 kGy;

[0113] Drying: Vacuum drying for 6 hours.

[0114] Performance testing:

[0115] Antibacterial rate: The antibacterial rates against Staphylococcus aureus and Escherichia coli are both 99.9%;

[0116] Sustained-release period: In 37°C physiological saline, the release amount of triclosan is 50% on the 7th day and reaches 85% on the 28th day;

[0117] Adhesion: 3.8 MPa, no peeling after soaking for 28 days;

[0118] Cytotoxicity: The survival rate of L929 fibroblasts is 95%.

[0119] Example 2: Preparation of triclosan antibacterial coating for PET multifilament non-absorbable suture

[0120] Substrate: Polyethylene terephthalate braided thread, porosity 30%, friction coefficient 0.08.

[0121] Preparation steps:

[0122] 1. Substrate pretreatment:

[0123] Plasma cleaning: Power 150 W, time 20 minutes, surface energy increased to 45 mN / m;

[0124] Surface roughening: Sandblasting treatment, porosity increased to 35%.

[0125] 2. Coating solution preparation:

[0126] Formula: 6 g of triclosan, 30 g of polyvinylpyrrolidone, 3 g of polyethylene glycol 400, 1 g of titanium dioxide;

[0127] Solvent: 80 g of tetrahydrofuran, viscosity 300 mPa·s after ultrasonic dispersion.

[0128] 3. Coating application:

[0129] Spraying process: Atomizing pressure 0.3 MPa, spraying rate 1.0 g / min, coating thickness 15.5 μm, coverage rate 95%.

[0130] 4. Curing treatment:

[0131] Thermal cross-linking: Baked at 80°C for 40 minutes, cross-linking degree greater than 90%.

[0132] 5. Post-treatment:

[0133] Sterilization: Ethylene oxide gas, humidity 60%, temperature 55°C, sterilization cycle 12 hours.

[0134] Performance testing:

[0135] Antibacterial rate: The antibacterial rate against Pseudomonas aeruginosa is 98.5%;

[0136] Sustained-release period: 55% of triclosan is released in 28 days, and the residue is less than 5%;

[0137] Mechanical properties: The retention rate of breaking strength is 98%;

[0138] Wear resistance: The coating loss rate after friction testing is less than 3%.

[0139] Example 3: Preparation of triclosan / chitosan composite coating for PGLA multifilament absorbable suture

[0140] Substrate: Poly(glycolide-lactide) braided thread, degradation period 60 days.

[0141] Preparation steps:

[0142] 1. Substrate pretreatment:

[0143] Plasma cleaning: Power 250W, time 10 minutes, amino grafting rate up to 8%;

[0144] Surface roughening: Alkali treatment, porosity 25%.

[0145] 2. Coating solution preparation:

[0146] Formulation: 10 g of triclosan, 24 g of chitosan, 1.2 g of vitamin E, 4.8 g of phosphate buffer;

[0147] Solvent: 100 g of 1% acetic acid solution, magnetically stirred until completely dissolved.

[0148] 3. Coating application:

[0149] Dip coating: Dipping speed 10 mm / s, pulling speed 5 mm / s, coating thickness 31 μm.

[0150] 4. Curing treatment:

[0151] Solvent evaporation: Ventilate and dry at 25°C for 24 hours to form a dense film layer.

[0152] 5. Post-treatment:

[0153] Sterilization: γ-ray irradiation at 20 kGy.

[0154] Performance testing:

[0155] Antibacterial rate: The antibacterial rate against methicillin-resistant Staphylococcus aureus is 97%;

[0156] Degradation synchrony: The coating is completely degraded on the 60th day, synchronous with the poly (lactic-co-glycolic acid) substrate;

[0157] Inflammatory response: After subcutaneous implantation in rats for 28 days, the levels of inflammatory factors are not different from those of the uncoated suture.

[0158] Example 4: Preparation of triclosan / chitosan composite coating for UHMWPE multifilament non-absorbable suture

[0159] Substrate: Ultra-high molecular weight polyethylene braided thread, porosity 25%, tensile strength 600 MPa.

[0160] Preparation steps:

[0161] 1. Substrate pretreatment:

[0162] Plasma cleaning: Power 250 W, time 25 minutes, surface energy increased to 50 mN / m;

[0163] Surface roughening: Plasma etching to form nanoscale pits.

[0164] 2. Coating solution preparation:

[0165] Formulation: 3 g of triclosan, 34 g of chitosan, 2 g of titanium dioxide, 1 g of triethyl citrate;

[0166] Solvent: 100 g of 1% acetic acid solution, viscosity 250 mPa·s after ultrasonic dispersion.

[0167] 3. Coating application:

[0168] Dip coating: Dipping time 30 seconds, pulling speed 3 mm / s, coating thickness 12.5 μm.

[0169] 4. Curing treatment:

[0170] Solvent evaporation: Ventilation drying at 25°C for 48 hours to form a porous sustained-release structure.

[0171] 5. Post-treatment:

[0172] Sterilization: γ-ray irradiation at 30 kGy, residual solvent less than 0.1% after vacuum drying.

[0173] Performance testing:

[0174] Abrasion resistance: The coating retention rate is greater than 95% after 5000 friction tests;

[0175] Antibacterial persistence: The antibacterial rate is still greater than 97% after accelerated aging;

[0176] Biocompatibility: The secretion amount of macrophage inflammatory factors is compared with that of traditional coatings.

[0177] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the said element.

[0178] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A triclosan antibacterial coating surgical suture and its preparation method, characterized in that: The suture includes a substrate and a surface antibacterial coating; the substrate is selected from absorbable monofilament materials, absorbable multifilament materials, non-absorbable monofilament materials, and non-absorbable multifilament materials; the antibacterial coating contains triclosan, a polymer carrier, and an adjuvant, wherein triclosan accounts for 20% of the total mass of the coating, the polymer carrier accounts for 75%, and the adjuvant accounts for 10%; the preparation method includes the following steps: S1. Substrate pretreatment: The suture substrate is subjected to plasma cleaning and surface roughening treatment for 20 minutes at a power of 175 W; S2. Coating solution preparation: Dissolve triclosan and the polymer carrier in an organic solvent, add the adjuvant, and ultrasonically disperse to form a uniform solution with a solution concentration of 30 wt%; S3. Coating application: The coating solution is uniformly applied to the surface of the substrate by dip coating, electrospinning, and spraying processes, and the coating thickness is 28 μm; S4. Curing treatment: The coating is fixed on the surface of the substrate by ultraviolet curing, thermal crosslinking, and solvent evaporation. The curing temperature is 80 °C and the time is 1 hour; S5. Post-treatment: The coated suture is sterilized and dried, and the sterilization methods are ethylene oxide and γ-ray irradiation.

2. The triclosan antibacterial coating surgical suture according to claim 1, wherein: The absorbable monofilament material is selected from polydioxanone; The absorbable multifilament material is selected from poly(glycolide-lactide) copolymer; The non-absorbable monofilament material is selected from polyvinylidene fluoride; The non-absorbable multifilament material is selected from polyethylene terephthalate.

3. The triclosan antibacterial coating surgical suture according to claim 1, wherein: The monofilament diameter of the absorbable monofilament material is 0.2 mm, and the breaking strength is greater than 300 MPa; the porosity of the braided wire of the non-absorbable multifilament material is 25%, and the surface friction coefficient is less than 0.

1.

4. A triclosan antibacterial coated surgical suture according to claim 1 and its preparation method, characterized in that: The polymer carrier is poly(lactic-co-glycolic acid), polyvinylpyrrolidone, and chitosan; The organic solvent is tetrahydrofuran, dichloromethane, and ethyl acetate.

5. The triclosan antibacterial coating surgical suture according to claim 1, wherein: When the polymer carrier is poly(lactic-co-glycolic acid), the molar ratio of lactic acid to glycolic acid is 60:40, and the molecular weight is 110 kDa; When the polymer carrier is chitosan, its degree of deacetylation is greater than 80%, and the viscosity is 600 mPa·s.

6. The triclosan antibacterial coating surgical suture according to claim 1, characterized in that: The adjuvant includes a plasticizer, an antioxidant, and a pH regulator; The plasticizer is triethyl citrate, and the addition amount is 5% of the total mass of the coating; The antioxidant is vitamin E and propyl gallate, and the addition amount is 1.5% of the total mass of the coating; The pH regulator is a phosphate buffer, and the addition amount is 2% of the total mass of the coating.

7. The triclosan antibacterial coated surgical suture according to claim 1, characterized in that: The concentration of the coating solution in step S2 is calculated by the following formula: The meanings of the parameters in the formula are as follows: C: The mass fraction of the coating solution, controlling the coating loading amount; m1: The mass of triclosan, in the range of 0.5 - 15 g; m2: The mass of the polymer carrier, in the range of 6 - 54 g; m3: The mass of the organic solvent, in the range of 5 - 100 g.

8. The triclosan antibacterial coating surgical suture according to claim 1, wherein: The thermal crosslinking curing time in step S4 is determined by the following formula: The meanings of the parameters in the formula are as follows: t: The curing time, in the range of 10 seconds - 2 hours; A: Pre-exponential factor, with a value ranging from 1×10 -6 to 1×10 -3 ; E a : Reaction activation energy, ranging from 30 to 80 kJ / mol; R: The gas constant; T: The curing temperature, in the range of 298 - 393 K.

9. The triclosan antibacterial coated surgical suture according to claim 1, characterized in that: The coating further includes nano silver particles and titanium dioxide photocatalyst, with a particle size of 60 nm, an addition amount of 2% of the total mass of the coating, and a synergistic antibacterial system is formed with triclosan.

10. A triclosan antibacterial coating surgical suture according to claims 1-9 and its preparation method, characterized in that: In step S5, the γ-ray irradiation dose is 21 kGy, the drying treatment is vacuum drying, the temperature is 45 °C, the vacuum degree is less than -0.08 MPa, and the drying time is 7 hours; The antibacterial rate of the final suture is greater than 99.9%, and the sustained release time of the coating in 37 °C physiological saline reaches 18 days.

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