Ultrasonic cross-flow extraction system

Abstract

The invention relates to the technical field of pharmaceutical equipment, and provides an ultrasonic cross-flow extraction system which is characterized in that an ultrasonic extraction tank comprises a first inlet and a first outlet; the decoloration and deodorization tank comprises a second inlet and a second outlet; the first pipeline is connected with the first outlet through the first valve body and connected with the second inlet through the second valve body, the second pipeline is connected with the first inlet through the third valve body and connected with the second outlet through the fourth valve body, and one end of the third pipeline is connected with the first pipeline to form a first intersection point. The other end of the third pipeline is connected with the second pipeline to form a second intersection point, one end of the fourth pipeline is connected with the first pipeline to form a third intersection point, the other end of the fourth pipeline is connected with the second pipeline to form a fourth intersection point, and the third pipeline and the fourth pipeline can selectively connect or disconnect the first pipeline and the second pipeline; the circulating pump is installed on the second pipeline and located between the second intersection point and the fourth intersection point. The ultrasonic cross-flow extraction system can provide multiple working modes to adapt to multiple working conditions.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical equipment, in particular to an ultrasonic cross-flow extraction system. Background Art

[0002] An ultrasonic extractor is a device that utilizes the physical effects of ultrasound (such as cavitation, mechanical, and thermal effects) to efficiently extract substances. Its core principle is to generate high-frequency mechanical vibration waves (typically 20kHz-1000kHz) through a piezoelectric transducer. This disrupts the cellular structure of the target substance or weakens the solid-liquid interaction, accelerating the dissolution of the active ingredient in the solvent. Compared with traditional methods, it offers advantages in speed, low temperature, and low energy consumption, making it suitable for extracting heat-sensitive substances.

[0003] Ultrasonic extractors are widely used in the extraction of Chinese herbal medicines and natural products, food processing, biological products and medicine, environmental protection and industry, and other high-tech fields. With the in-depth development of modern industry, especially in the fields of Chinese herbal medicine and natural product extraction and biomedicine, the traditional ultrasonic extractor, which consists of an extraction tank, a single-frequency ultrasonic generator, and a mechanical stirring paddle, can no longer meet the needs of diverse raw materials and processes.

[0004] Therefore, there is an urgent need for an ultrasonic cross-flow extraction system to solve the above technical problems. Summary of the Invention

[0005] The purpose of the present invention is to provide an ultrasonic cross-flow extraction system that can provide multiple working modes to adapt to various working conditions and improve operating efficiency.

[0006] To achieve this object, the present invention adopts the following technical solutions:

[0007] Ultrasonic cross-flow extraction system, including:

[0008] An ultrasonic extraction tank comprising a first inlet and a first outlet;

[0009] a decolorization and deodorization tank, comprising a second inlet and a second outlet;

[0010] A pipe assembly includes a first pipe, a second pipe, a third pipe, and a fourth pipe. The first pipe is connected to the first outlet through a first valve body and to the second inlet through a second valve body. The second pipe is connected to the first inlet through a third valve body and to the second outlet through a fourth valve body. One end of the third pipe is connected to the first pipe to form a first intersection, and the other end of the third pipe is connected to the second pipe to form a second intersection. One end of the fourth pipe is connected to the first pipe to form a third intersection, and the other end of the fourth pipe is connected to the second pipe to form a fourth intersection. The third pipe and the fourth pipe are both capable of selectively connecting or disconnecting the first pipe from the second pipe.

[0011] The circulation pump is installed on the second pipeline and is located between the second intersection point and the fourth intersection point.

[0012] As a preferred technical solution of the ultrasonic cross-flow extraction system, it also includes a pipeline sight glass, which is installed in the first pipeline and is located between the first intersection and the third intersection.

[0013] As a preferred technical solution of the ultrasonic cross-flow extraction system, a filter is further included, and the filter is installed at the second outlet.

[0014] As a preferred technical solution of the above ultrasonic cross-flow extraction system, it also includes a fifth valve body and a sixth valve body. The fifth valve body and the sixth valve body are both installed in the third pipeline and are respectively located at the two ends of the third pipeline.

[0015] As a preferred technical solution of the above ultrasonic cross-flow extraction system, it also includes a seventh valve body and an eighth valve body. The seventh valve body and the eighth valve body are both installed in the fourth pipeline and are respectively located at the two ends of the fourth pipeline.

[0016] As a preferred technical solution for the above-mentioned ultrasonic cross-flow extraction system, the above-mentioned second pipeline includes a first interface, a second interface and a third interface. The above-mentioned first interface, the above-mentioned second interface and the above-mentioned third interface are connected to each other, the above-mentioned first interface is connected to the above-mentioned second outlet, the above-mentioned second interface is connected to the above-mentioned first inlet, the above-mentioned third interface is the outlet of the above-mentioned ultrasonic cross-flow extraction system, and the above-mentioned third interface is installed with a ninth valve body for controlling the on and off of the above-mentioned third interface.

[0017] As a preferred technical solution of the ultrasonic cross-flow extraction system, it further includes a tenth valve body, which is installed in the second pipeline between the fourth intersection and the third valve body.

[0018] As a preferred technical solution of the above-mentioned ultrasonic cross-flow extraction system, the above-mentioned ultrasonic extraction tank includes a first inner liner and a first outer shell. The above-mentioned first inner liner is installed in the above-mentioned first outer shell. The above-mentioned first inner liner is provided with a through hole. The first ultrasonic rod and the second ultrasonic rod are installed in the above-mentioned first inner liner. The vibration frequency of the above-mentioned first ultrasonic rod is different from the vibration frequency of the above-mentioned second ultrasonic rod.

[0019] As a preferred technical solution of the ultrasonic cross-flow extraction system, the ultrasonic extraction tank further includes a temperature regulating member, which is used to change the temperature of the ultrasonic extraction tank.

[0020] As a preferred technical solution of the above-mentioned ultrasonic cross-flow extraction system, the above-mentioned decolorization and deodorization tank includes a second inner liner and a second outer shell. The above-mentioned second inner liner is installed in the above-mentioned second outer shell. The above-mentioned second inner liner is provided with a through hole. A decolorization and deodorization aid is installed in the above-mentioned second inner liner.

[0021] Beneficial effects of the present invention:

[0022] The present invention provides an ultrasonic cross-flow extraction system, comprising an ultrasonic extraction tank, a decolorization and deodorization tank, a pipe assembly, and a circulation pump. The ultrasonic extraction tank comprises a first inlet and a first outlet; the decolorization and deodorization tank comprises a second inlet and a second outlet; the pipe assembly comprises a first pipe, a second pipe, a third pipe, and a fourth pipe, wherein the first pipe is connected to the first outlet via a first valve body and to the second inlet via a second valve body; the second pipe is connected to the first inlet via a third valve body and to the second outlet via a fourth valve body; one end of the third pipe is connected to the first pipe to form a first intersection; the other end of the third pipe is connected to the second pipe to form a second intersection; one end of the fourth pipe is connected to the first pipe to form a third intersection; the other end of the fourth pipe is connected to the second pipe to form a fourth intersection; and both the third pipe and the fourth pipe can selectively connect or disconnect the first pipe from the second pipe; and the circulation pump is installed in the second pipe and is located between the second intersection and the fourth intersection.

[0023] During use, the ultrasonic cross-flow extraction system includes three working modes, which are respectively recorded as the first working mode, the second working mode and the third working mode.

[0024] When the ultrasonic cross-flow extraction system only needs to perform extraction operations, the first working mode is turned on. In this mode, the ultrasonic cross-flow extraction system closes the decolorization and deodorization tank, the second valve body, the fourth valve body and the fourth pipeline, and opens the ultrasonic extraction tank, the first valve body, the third pipeline, the circulation pump and the third valve body. In this way, the medium can pass through the first outlet of the ultrasonic extraction tank, the first pipeline, enter the third pipeline at the first intersection, enter the second pipeline at the second intersection, and finally return to the ultrasonic extraction tank from the first inlet. This cycle is repeated. The solvent in the ultrasonic extraction tank forms a continuous cross flow during the repeated circulation, so that the dissolved matter is evenly dispersed in real time, which helps to improve the extraction efficiency.

[0025] When the ultrasonic cross-flow extraction system only needs to perform decolorization and deodorization operations, the second working mode is turned on. In this mode, the ultrasonic cross-flow extraction system closes the ultrasonic extraction tank, the first valve body, the third pipeline and the third valve body, and opens the decolorization and deodorization tank, the second valve body, the fourth valve body, the fourth pipeline and the circulation pump. In this way, the medium can pass through the second outlet of the decolorization and deodorization tank, the second pipeline, enter the fourth pipeline at the fourth intersection, enter the first pipeline at the third intersection, and finally return to the decolorization and deodorization tank from the second inlet, and repeat the cycle.

[0026] When the ultrasonic cross-flow extraction system needs to perform extraction operations and decolorization and deodorization operations at the same time, the third working mode is started. In this mode, the ultrasonic cross-flow extraction system closes the third pipeline and the fourth pipeline, opens the first valve body, the second valve body, the fourth valve body, the third valve body, the ultrasonic extraction tank, the decolorization and deodorization tank and the circulation pump, so that the medium can pass through the first outlet of the ultrasonic extraction tank, the first pipeline, the second inlet of the decolorization and deodorization tank, the second outlet, the second pipeline, and finally return to the ultrasonic extraction tank from the first feed port, and the cycle is repeated.

[0027] In this way, the ultrasonic cross-flow extraction system can have multiple working modes and can switch to the corresponding working mode according to the operation type of the biological material, thereby improving the extraction efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in describing the embodiments of the present invention. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the contents of the embodiments of the present invention and these drawings without any creative work.

[0029] Figure 1 1 is a schematic structural diagram of an ultrasonic cross-flow extraction system provided by an embodiment of the present invention;

[0030] Figure 2 This is a flow chart of a first working mode of an ultrasonic cross-flow extraction system provided by an embodiment of the present invention;

[0031] Figure 3 is a flow chart of a second working mode of the ultrasonic cross-flow extraction system provided by an embodiment of the present invention;

[0032] Figure 4 This is a flow chart of the third working mode of the ultrasonic cross-flow extraction system provided by an embodiment of the present invention.

[0033] In the picture:

[0034] 1. Ultrasonic extraction tank; 1a. First inlet; 1b. First outlet; 11. First liner; 12. First outer shell; 13. First ultrasonic rod; 14. Second ultrasonic rod; 15. Jacket;

[0035] 2. Decolorization and deodorization tank; 2a. Second inlet; 2b. Second outlet; 21. Second liner; 22. Second outer shell;

[0036] 31. First pipeline; 31a. First valve body; 31b. Second valve body; 32. Second pipeline; 32a. Third valve body; 32b. Fourth valve body; 32c. Ninth valve body; 32d. Tenth valve body; 33. Third pipeline; 33a. Fifth valve body; 33b. Sixth valve body; 34. Fourth pipeline; 34a. Seventh valve body; 34b. Eighth valve body; 35. First intersection; 36. Second intersection; 37. Third intersection; 38. Fourth intersection;

[0037] 4. Circulation pump; 5. Pipeline sight glass; 6. Filter. DETAILED DESCRIPTION

[0038] The present invention will be further described in detail below with reference to the accompanying drawings and examples. It will be understood that the specific embodiments described herein are intended only to illustrate the present invention and are not intended to limit the present invention. It should also be noted that, for ease of description, the accompanying drawings only illustrate portions relevant to the present invention, not all structures.

[0039] In the description of the present invention, unless otherwise expressly specified or limited, the terms "connected," "connected," and "fixed" should be understood in a broad sense. For example, they may refer to fixed connections, detachable connections, or integration; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal communication between two components or interaction between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention in specific circumstances.

[0040] In the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Furthermore, a first feature being "above," "above," and "above" a second feature may include the first feature being directly above or obliquely above the second feature, or may simply mean that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature may include the first feature being directly below or obliquely below the second feature, or may simply mean that the first feature is lower in level than the second feature.

[0041] In the description of this embodiment, the terms "upper," "lower," "right," and other orientations or positional relationships are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely for ease of description and simplified operation. They do not indicate or imply that the devices or components referred to must have, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on the present invention. Furthermore, the terms "first" and "second" are used solely for descriptive purposes and have no special meanings.

[0042] like Figures 1 to 4As shown, the present invention provides an ultrasonic cross-flow extraction system, which includes an ultrasonic extraction tank 1, a decolorization and deodorization tank 2, a pipe group and a circulation pump 4. Among them, the ultrasonic extraction tank 1 includes a first inlet 1a and a first outlet 1b; the decolorization and deodorization tank 2 includes a second inlet 2a and a second outlet 2b; the tube group includes a first pipe 31, a second pipe 32, a third pipe 33 and a fourth pipe 34, the first pipe 31 is connected to the first outlet 1b through a first valve body 31a and is connected to the second inlet 2a through a second valve body 31b, the second pipe 32 is connected to the first inlet 1a through a third valve body 32a and is connected to the second outlet 2b through a fourth valve body 32b, one end of the third pipe 33 is connected to the first pipe 31 to form a first intersection 35, the other end of the third pipe 33 is connected to the second pipe 32 to form a second intersection 36, one end of the fourth pipe 34 is connected to the first pipe 31 to form a third intersection 37, and the other end of the fourth pipe 34 is connected to the second pipe 32 to form a fourth intersection 38, and the third pipe 33 and the fourth pipe 34 can selectively connect or disconnect the first pipe 31 and the second pipe 32; the circulating pump 4 is installed in the second pipe 32 and is located between the second intersection 36 and the fourth intersection 38.

[0043] Exemplarily, the ultrasonic extraction tank 1 is used to carry medicinal materials, and the ultrasonic extraction tank 1 can perform extraction operations on biological materials, such as medicinal materials, using ultrasound; the decolorization and deodorization tank 2 is used to decolorize and deodorize the medium; the tube group is used to enable the medium to circulate between the ultrasonic extraction tank 1 and the decolorization and deodorization tank 2, circulate between the decolorization and deodorization tank 2 and part of the tube group, or circulate between the ultrasonic extraction tank 1 and part of the tube group.

[0044] It should be noted that the ultrasonic extraction tank 1 is an existing device, and its specific structure and working principle are not described here in detail.

[0045] It should be noted that the decolorization and deodorization tank 2 is an existing device, and its specific structure and working principle are not described here in detail.

[0046] During use, the ultrasonic cross-flow extraction system includes three working modes, which are respectively recorded as the first working mode, the second working mode and the third working mode.

[0047] When the ultrasonic cross-flow extraction system only needs to perform extraction operations, the first working mode is turned on. In this mode, the ultrasonic cross-flow extraction system closes the decolorization and deodorization tank 2, the second valve body 31b, the fourth valve body 32b and the fourth pipe 34, and opens the ultrasonic extraction tank 1, the first valve body 31a, the third pipe 33, the circulation pump 4 and the third valve body 32a. In this way, the medium can pass through the first outlet 1b of the ultrasonic extraction tank 1, the first pipe 31, enter the third pipe 33 at the first intersection 35, enter the second pipe 32 at the second intersection 36, and finally return to the ultrasonic extraction tank 1 from the first inlet 1a. This cycle is repeated. The solvent in the ultrasonic extraction tank 1 forms a continuous cross flow during the repeated circulation, so that the dissolved matter is evenly dispersed in real time, which helps to improve the extraction efficiency.

[0048] When the ultrasonic cross-flow extraction system only needs to perform decolorization and deodorization operations, the second working mode is turned on. In this mode, the ultrasonic cross-flow extraction system closes the ultrasonic extraction tank 1, the first valve body 31a, the third pipe 33 and the third valve body 32a, and opens the decolorization and deodorization tank 2, the second valve body 31b, the fourth valve body 32b, the fourth pipe 34 and the circulation pump 4. In this way, the medium can pass through the second outlet 2b of the decolorization and deodorization tank 2, the second pipe 32, enter the fourth pipe 34 at the fourth intersection 38, enter the first pipe 31 at the third intersection 37, and finally return to the decolorization and deodorization tank 2 from the second inlet 2a, and repeat the cycle.

[0049] When the ultrasonic cross-flow extraction system needs to perform extraction and decolorization and deodorization operations simultaneously, the third working mode is started. In this mode, the ultrasonic cross-flow extraction system closes the third pipe 33 and the fourth pipe 34, and opens the first valve body 31a, the second valve body 31b, the fourth valve body 32b, the third valve body 32a, the ultrasonic extraction tank 1, the decolorization and deodorization tank 2 and the circulation pump 4, so that the medium can pass through the first outlet 1b of the ultrasonic extraction tank 1, the first pipe 31, the second inlet 2a of the decolorization and deodorization tank 2, the second outlet 2b, the second pipe 32, and finally return to the ultrasonic extraction tank 1 from the first feed port, and the cycle is repeated.

[0050] In this way, the ultrasonic cross-flow extraction system can have multiple working modes and can switch to the corresponding working mode according to the operation type of the biological material, thereby improving the extraction efficiency.

[0051] Preferably, the circulation pump 4 is a variable frequency hot water pump.

[0052] Optionally, the ultrasonic cross-flow extraction system further includes a pipeline sight glass 5 , which is installed on the first pipeline 31 and located between the first intersection point 35 and the third intersection point 37 .

[0053] Exemplarily, the pipe sight glass 5 is an observation device in an industrial piping system, primarily used to monitor the flow state, color, phase, or other physical properties of the medium within the pipe in real time. In this embodiment, after the ultrasonic cross-flow extraction system is activated, regardless of whether it is in the first, second, or third operating mode, the medium within the pipe group will flow through the pipe sight glass 5. The user can use the pipe sight glass 5 to obtain the physical properties of the medium within the first pipe 31, such as the medium's color, and use this color to determine the current operation progress.

[0054] Optionally, the ultrasonic cross-flow extraction system further includes a filter 6 , which is installed at the second outlet 2 b.

[0055] Exemplarily, the inlet end of the filter 6 is connected to the second outlet 2b of the decolorization and deodorization tank 2, and the outlet end of the filter 6 is connected to the second pipe 32. The filter 6 is used to intercept impurities mixed in the medium discharged from the decolorization and deodorization tank 2 to keep the medium pure.

[0056] Furthermore, the filter 6 is a spherical filter.

[0057] Optionally, the ultrasonic cross-flow extraction system further includes a fifth valve body 33 a and a sixth valve body 33 b . The fifth valve body 33 a and the sixth valve body 33 b are both installed in the third pipe 33 and are located at both ends of the third pipe 33 .

[0058] Exemplarily, the head end of the third pipe 33 is connected to the first pipe 31 to form a first intersection 35, and the tail end of the third pipe 33 is connected to the second pipe 32 to form a second intersection 36. The fifth valve body 33a is installed at the head end of the third pipe 33 and can control the on / off state of the head end of the third pipe 33. The sixth valve body 33b is installed at the tail end of the third pipe 33 and can control the on / off state of the tail end of the third pipe 33. When the fifth valve body 33a and / or the sixth valve body 33b are in a closed state, the third pipe 33 is in a blocked state, and the medium cannot pass between the first pipe 31 and the second pipe 32 through the third pipe 33. When the fifth valve body 33a and the sixth valve body 33b are both in an open state, the third pipe 33 is in a connected state, and the medium can pass between the first pipe 31 and the second pipe 32 through the third pipe 33. That is, when the ultrasonic cross-flow extraction system is in the first working mode, the fifth valve body 33a and the sixth valve body 33b are both in the open state, so that the medium in the first pipe 31 enters the second pipe 32 through the third pipe 33 and returns to the ultrasonic extraction tank 1 without entering the decolorization and deodorization tank 2; when the ultrasonic cross-flow extraction system is in the second working mode or the third working mode, the fifth valve body 33a and the sixth valve body 33b are both in the closed state, and the third pipe 33 does not participate in the transportation of the medium.

[0059] In this way, since the fifth valve body 33a and the sixth valve body 33b are respectively located at the head and tail ends of the third pipeline 33, when the third pipeline 33 is no longer needed to participate in the transportation of the medium, the closing of the fifth valve body 33a and the sixth valve body 33b can greatly prevent the medium from flowing into the third pipeline 33 and causing the medium to remain in the third pipeline 33.

[0060] Optionally, the ultrasonic cross-flow extraction system further includes a seventh valve body 34 a and an eighth valve body 34 b . The seventh valve body 34 a and the eighth valve body 34 b are both installed in the fourth pipe 34 and are located at both ends of the fourth pipe 34 .

[0061] Exemplarily, the head end of the fourth pipe 34 is connected to the first pipe 31 to form a third intersection 37, and the tail end of the fourth pipe 34 is connected to the second pipe 32 to form a fourth intersection 38. The seventh valve body 34a is installed at the head end of the fourth pipe 34 and can control the on / off state of the head end of the fourth pipe 34. The eighth valve body 34b is installed at the tail end of the fourth pipe 34 and can control the on / off state of the tail end of the fourth pipe 34. When the seventh valve body 34a and / or the eighth valve body 34b are in a closed state, the fourth pipe 34 is in a blocked state, and the medium cannot pass between the first pipe 31 and the second pipe 32 through the fourth pipe 34. When the seventh valve body 34a and the eighth valve body 34b are both in an open state, the fourth pipe 34 is in a connected state, and the medium can pass between the first pipe 31 and the second pipe 32 through the fourth pipe 34. That is, when the ultrasonic cross-flow extraction system is in the second working mode, the seventh valve body 34a and the eighth valve body 34b are both in the open state, so that the medium in the second pipe 32 enters the first pipe 31 through the fourth pipe 34, and then returns to the decolorization and deodorization tank 2 without entering the ultrasonic extraction tank 1; when the ultrasonic cross-flow extraction system is in the first working mode or the third working mode, the seventh valve body 34a and the eighth valve body 34b are both in the closed state, and the fourth pipe 34 does not participate in the transportation of the medium.

[0062] In this way, since the seventh valve body 34a and the eighth valve body 34b are respectively located at the head and tail ends of the fourth pipeline 34, when the fourth pipeline 34 is no longer needed to participate in the transportation of the medium, the closing of the seventh valve body 34a and the eighth valve body 34b can greatly prevent the medium from flowing into the fourth pipeline 34 and causing the medium to remain in the fourth pipeline 34.

[0063] Optionally, the second pipeline 32 includes a first interface, a second interface and a third interface, the first interface, the second interface and the third interface are connected to each other, the first interface is connected to the second outlet 2b, the second interface is connected to the first inlet 1a, the third interface is the outlet of the ultrasonic cross-flow extraction system, and the third interface is installed with a ninth valve body 32c for controlling the on and off of the third interface.

[0064] With this configuration, when the ultrasonic cross-flow extraction system is in an operating mode (i.e., any of the first, second, or third operating modes), the ninth valve body 32c is closed, preventing the medium from exiting the ultrasonic cross-flow extraction system and allowing it to circulate within the system. When the ultrasonic cross-flow extraction system completes its operation, the ninth valve body 32c opens, allowing the medium to exit the system through the third port.

[0065] Optionally, the ultrasonic cross-flow extraction system further includes a tenth valve body 32d, which is installed in the second pipeline 32 between the fourth intersection 38 and the third valve body 32a.

[0066] Exemplarily, the tenth valve body 32d is installed on the second pipe 32 and on the adjacent side of the fourth intersection 38. In this way, when the ultrasonic cross-flow extraction system is in the second working mode, the tenth valve body 32d is closed, so that the medium can pass through the fourth pipe 34 at the fourth intersection 38 as much as possible into the first pipe 31, thereby reducing the medium retention in the second pipe 32.

[0067] Optionally, the ultrasonic extraction tank 1 includes a first inner liner 11 and a first outer shell 12. The first inner liner 11 is installed in the first outer shell 12. The first inner liner 11 is provided with a through hole. A first ultrasonic rod 13 and a second ultrasonic rod 14 are installed in the first inner liner 11. The vibration frequency of the first ultrasonic rod 13 is different from the vibration frequency of the second ultrasonic rod 14.

[0068] Exemplarily, the interior of the first liner 11 forms a first chamber a, the first liner 11 is installed in the first outer shell 12, and the first chamber b is formed between the first liner 11 and the first outer shell 12. The first chamber a is used to carry biological materials, such as medicinal materials. The first ultrasonic rod 13 and the second ultrasonic rod 14 are installed in the first chamber a. The ultrasonic extraction tank 1 can only start the first ultrasonic rod 13 or only start the second ultrasonic rod 14 to extract the biological materials in the first chamber a. It can also start the first ultrasonic rod 13 and the second ultrasonic rod 14 at the same time to extract the biological materials in the first chamber a. In this way, the ultrasonic extraction tank 1 can selectively output a variety of vibration frequencies. The user can use the corresponding vibration frequencies for extraction operations for biological materials of different properties to improve the extraction efficiency. The first liner 11 is provided with a through hole, which can connect the first chamber a and the first chamber b. The medium extracted from the biological material can enter the first chamber b from the first chamber a and then enter the tube group for circulation.

[0069] Preferably, the mesh number of the through holes of the first inner liner 11 is between 100 mesh and 200 mesh.

[0070] Optionally, the ultrasonic extraction tank 1 further includes a temperature regulating member, which is used to change the temperature of the ultrasonic extraction tank 1 .

[0071] In this embodiment, the second shell 22 is provided with a jacket 15, which is a temperature regulating component. A high-temperature refrigerant can be introduced into the jacket 15 to heat the ultrasonic extraction tank 1, or a low-temperature refrigerant can be introduced into the jacket 15 to cool the ultrasonic extraction tank 1.

[0072] Optionally, the decolorization and deodorization tank 2 includes a second inner liner 21 and a second outer shell 22 . The second inner liner 21 is installed in the second outer shell 22 . The second inner liner 21 is provided with a through hole. A decolorization and deodorization aid is installed in the second inner liner 21 .

[0073] For example, the interior of the second inner liner 21 forms a second chamber a, which is mounted within the second outer shell 22. A second chamber b is formed between the second inner liner 21 and the second outer shell 22. Second chamber a is used to hold a decolorization and deodorization agent, such as activated carbon. The medium entering the decolorization and deodorization tank 2 through the second inlet 2a flows through the second chamber a, then through the through-hole into the second chamber b, and then circulates within the tube assembly.

[0074] Preferably, the mesh size of the through holes of the second inner container 21 is between 200 mesh and 300 mesh. Further, the following extraction experiments using alkaloids, total polysaccharides, total polyphenols and saponins are conducted to demonstrate the effectiveness of the ultrasonic cross-flow extraction system provided in the present invention in actual use.

[0075] Assume that the first ultrasonic rod 13 can provide 20 kHz ultrasonic waves, and the second ultrasonic rod 14 can provide 40 kHz ultrasonic waves.

[0076] Example 1: Alkaloid extraction.

[0077] Put 500g of Sophora flavescens slices into the first inner tank 11 of the ultrasonic extraction tank 1, add 20L of pure water (material-liquid ratio 1:40), set the extraction temperature to 60℃,

[0078] Use a 40kHz single ultrasonic wave and a circulating pump at a flow rate of 200L / h. Extract for 30 minutes. After extraction, take 100ml of the extract and centrifuge at 4000rpm for 10 minutes. The supernatant is used as the sample for matrine testing. The test method follows the content determination for Sophora flavescens in Part 1 of the 2020 Chinese Pharmacopoeia.

[0079] Comparative Example 1: The difference from Example 1 is that 20KHZ and 40KHZ ultrasound are turned on at the same time, and other conditions are the same.

[0080] Comparative Example 2: 500g of Sophora flavescens slices were placed in a stirring ultrasonic extraction tank 1, 20L of pure water (material-liquid ratio 1:40) was added, the extraction temperature was set to 60°C, 40KHZ ultrasonic waves were turned on, stirring was turned on at 100r / m, and the extraction time was 30min. After the extraction, 100ml of the extract was taken and centrifuged at 4000r / m for 10min. The supernatant was taken as the test sample to test the matrine content. The test method was determined according to the content in Sophora flavescens in the 2020 edition of the Chinese Pharmacopoeia.

[0081] Example 2: Total polysaccharide extraction.

[0082] Put 500g of Polygonatum odoratum slices into the first inner tank 11 of the ultrasonic extraction tank 1, add 20L of pure water (material-liquid ratio 1:40), set the extraction temperature to 60℃,

[0083] Turn on a 40KHZ single ultrasonic wave, start the circulation pump 4 with a flow rate of 200L / h, and extract for 30 minutes. After the extraction, take 100ml of the extract and centrifuge at 4000r / m for 10 minutes. Take the supernatant as the sample to be tested for total polysaccharide content.

[0084] Comparative Example 3: The difference from Example 2 is that 20KHZ and 40KHZ ultrasound are turned on at the same time, and other conditions are the same.

[0085] Comparative Example 4: 500g of Polygonatum odoratum slices were placed in a stirred ultrasonic extraction tank 1, 20L of pure water was added (solid-liquid ratio 1:40), the extraction temperature was set to 60°C, 40kHz ultrasonic wave was turned on, stirring was started at 100 rpm, and the extraction time was 30 minutes. After the extraction was completed, 100ml of the extract was collected and centrifuged at 4000 rpm for 10 minutes. The supernatant was used as the sample to be tested for total polysaccharide content.

[0086] Example 3: Total polyphenol extraction.

[0087] 500g of scutellaria slices were put into the first inner container 11 of the ultrasonic extraction tank 1, 20L of pure water (material-liquid ratio 1:40) was added, and the extraction temperature was set to 60℃.

[0088] Start a single ultrasonic wave at 40 kHz and a circulating pump at a flow rate of 200 L / h. The extraction time is 30 minutes. After the extraction is complete, take 100 ml of the extract and centrifuge at 4000 rpm for 10 minutes. The supernatant is used as the sample to be tested for total polyphenol content.

[0089] Comparative Example 5: The difference from Example 3 is that 20KHZ and 40KHZ ultrasound are turned on at the same time, and other conditions are the same.

[0090] Comparative Example 6: 500g of Scutellaria baicalensis slices were placed in a stirred ultrasonic extraction tank (1), 20L of pure water was added (solid-to-liquid ratio 1:40), the extraction temperature was set to 60°C, 40kHz ultrasonic wave was activated, stirring was started at 100 rpm, and the extraction time was 30 minutes. After the extraction, 100ml of the extract was centrifuged at 4000 rpm for 10 minutes. The supernatant was used as the sample for total polyphenol content.

[0091] Example 4: Saponin extraction.

[0092] Put 500g of ginseng slices into the first inner tank 11 of the ultrasonic extraction tank 1, add 20L of pure water (material-liquid ratio 1:40), set the extraction temperature to 60℃,

[0093] Use a single ultrasonic wave at 40 kHz and a circulating pump at 200 L / h. Extract for 30 minutes. After extraction, take 100 ml of the extract and centrifuge at 4000 rpm for 10 minutes. The supernatant is used as the sample for ginsenoside content testing. The test method follows the content determination for ginsenosides in Part 1 of the Chinese Pharmacopoeia (2020 edition).

[0094] Comparative Example 7: The difference from Example 4 is that 20KHZ and 40KHZ ultrasound are turned on at the same time, and other conditions are the same.

[0095] Comparative Example 8: 500g of ginseng slices were placed in a stirred ultrasonic extraction tank 1, 20L of pure water (material-liquid ratio 1:40) was added, the extraction temperature was set to 60°C, 40KHZ ultrasonic waves were turned on, stirring was turned on at 100r / m, and the extraction time was 30min. After the extraction, 100ml of the extract was taken and centrifuged at 4000r / m for 10min. The supernatant was taken as the test sample to test the ginsenoside content. The test method was determined according to the content in ginseng in the 2020 edition of the Chinese Pharmacopoeia.

[0096] Determination of total sugar content:

[0097] (1) Experimental reagents: anhydrous glucose, phenol, concentrated sulfuric acid.

[0098] (2) Preparation of standard curve:

[0099] 1. Preparation of reference solution: Accurately weigh 10 mg of anhydrous glucose dried to constant weight at 120°C and place it in a 100 ml volumetric flask. Add purified water to the mark and shake well to prepare a 0.1 mg / mL reference solution.

[0100] 2. Preparation of a standard curve: Prepare glucose standard solutions at concentrations of 0.02, 0.04, 0.06, 0.08, and 0.10 mg / mL. Accurately pipette 1 mL of the standard solution into a test tube. Add 1 mL of 5% phenol solution, followed by 5 mL of concentrated sulfuric acid. Shake thoroughly. Place in a boiling water bath for 15 minutes. After cooling to room temperature, measure the absorbance at 485 nm. Plot a standard curve with concentration as the abscissa and absorbance as the ordinate. The results should have an R² ≥ 0.999.

[0101] (3) Sample determination:

[0102] Take 1 mL of filtered fermentation broth and add 1 mL of 5% phenol solution (phenol should be prepared immediately before use). Then add 5 mL of concentrated sulfuric acid to the test tube. Place in a boiling water bath for 15 minutes, cool to room temperature, and measure the concentration using a UV spectrophotometer.

[0103] Determination of polyphenol content:

[0104] (1) Experimental reagents: gallic acid, forlin phenol, sodium carbonate, ethanol.

[0105] (2) Preparation of standard curve:

[0106] 1. Preparation of reference solution: Accurately weigh 20 mg (accurate to 0.1 mg) of gallic acid standard and dissolve it in distilled water to a volume of 100 mL. The gallic acid content of this solution is 200 mg / L. Store in a refrigerator at 4°C away from light.

[0107] 2. Preparation of a standard curve: Accurately pipette 0.0, 0.2, 0.4, 0.6, 1.0, and 1.5 mL of gallic acid standard solution into 10 mL volumetric flasks, dilute to volume with distilled water to obtain gallic acid working solution. Then, pipette 1.0 mL of the gallic acid working solution into 10 mL colorimetric tubes, add 2.5 mL of folin-phenol reagent, shake well, add 2.5 mL of 15% Na₂CO₃ solution, dilute to the mark with water, and shake well. Incubate in a 40°C water bath for 60 minutes, then allow to cool for 20 minutes. Prepare a standard series with concentrations of 0 mg / L, 4 mg / L, 8 mg / L, 12 mg / L, 20 mg / L, and 30 mg / L. Measure the absorbance at 760 nm. Plot a standard curve with concentration as the horizontal axis and absorbance as the vertical axis. The results should have an R² ≥ 0.999.

[0108] (3) Sample determination:

[0109] Take 1 mL of filtered fermentation broth and add 2.5 mL of Folin-phenol reagent. Shake well. Then add 2.5 mL of 15% Na₂CO₃ solution to a 10 mL colorimetric tube. Add water to the mark and shake well. Incubate in a 40°C water bath for 60 minutes, then allow to cool for 20 minutes. Determine the content using a UV spectrophotometer.

[0110] The target substance contents of the extracts obtained by different processes are shown in the table:

[0111]

[0112]

[0113] From the analysis data, it can be seen that the simultaneous use of two frequencies of ultrasound has a significant effect on improving the extraction rate of the target substance; the comparative data show that cross-flow extraction has a significant advantage over stirring in improving the extraction rate of the target substance; the above is only a verification of the extraction rate. The advantages of the simultaneous extraction and decolorization and deodorization in the present invention are obvious, and no further examples and comparative examples will be analyzed. The application scope of the multi-frequency ultrasonic cross-flow extraction system of the present invention is not limited to the four Chinese medicines in the embodiment, and can also be applied to other Chinese medicinal materials or plant materials or other non-plant materials such as Selaginella, Centella asiatica, Licorice, Hamamelis virginiana, Cactus, Ophiopogon japonicus, Poria cocos, Polygonum multiflorum, Lithospermum officinale, etc.; the multi-frequency ultrasonic cross-flow extraction system of the present invention has an explosion-proof function, and the solvent can be water or an organic solvent.

[0114] Furthermore, the above are only preferred embodiments of the present invention and the technical principles employed. Those skilled in the art will appreciate that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments, and substitutions are possible for those skilled in the art without departing from the scope of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments and may include many other equivalent embodiments without departing from the scope of the present invention. The scope of the present invention is determined by the scope of the appended claims.

Claims

1. Ultrasonic cross-flow extraction system, characterized in that: include: An ultrasonic extraction tank (1) comprising a first inlet (1a) and a first outlet (1b); A decolorization and deodorization tank (2) comprising a second inlet (2a) and a second outlet (2b); A pipe group comprises a first pipe (31), a second pipe (32), a third pipe (33) and a fourth pipe (34), wherein the first pipe (31) is connected to the first outlet (1b) through a first valve body (31a) and is connected to the second inlet (2a) through a second valve body (31b), the second pipe (32) is connected to the first inlet (1a) through a third valve body (32a) and is connected to the second outlet (2b) through a fourth valve body (32b), one end of the third pipe (33) is connected to the first pipe (31 ) are connected to form a first intersection (35), the other end of the third pipe (33) is connected to the second pipe (32) to form a second intersection (36), one end of the fourth pipe (34) is connected to the first pipe (31) to form a third intersection (37), and the other end of the fourth pipe (34) is connected to the second pipe (32) to form a fourth intersection (38), and the third pipe (33) and the fourth pipe (34) are both capable of selectively connecting or disconnecting the first pipe (31) and the second pipe (32); A circulation pump (4) is installed in the second pipeline (32) and is located between the second intersection point (36) and the fourth intersection point (38).

2. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: The invention also comprises a pipeline sight glass (5), wherein the pipeline sight glass (5) is installed on the first pipeline (31) and is located between the first intersection point (35) and the third intersection point (37).

3. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: It also includes a filter (6), which is installed at the second outlet (2b).

4. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: It also includes a fifth valve body (33a) and a sixth valve body (33b), wherein the fifth valve body (33a) and the sixth valve body (33b) are both installed in the third pipeline (33) and are respectively located at two ends of the third pipeline (33).

5. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: It also includes a seventh valve body (34a) and an eighth valve body (34b), wherein the seventh valve body (34a) and the eighth valve body (34b) are both installed in the fourth pipeline (34) and are respectively located at both ends of the fourth pipeline (34).

6. The ultrasonic cross-flow extraction system according to claim 2, characterized in that: The second pipeline (32) includes a first interface, a second interface and a third interface, the first interface, the second interface and the third interface are connected to each other, the first interface is connected to the second outlet (2b), the second interface is connected to the first inlet (1a), the third interface is the outlet of the ultrasonic cross-flow extraction system, and the third interface is installed with a ninth valve body (32c) for controlling the opening and closing of the third interface.

7. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: The invention also includes a tenth valve body (32d), which is installed in the second pipe (32) between the fourth intersection (38) and the third valve body (32a).

8. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: The ultrasonic extraction tank (1) comprises a first inner liner (11) and a first outer shell (12), wherein the first inner liner (11) is installed in the first outer shell (12), a through hole is provided in the first inner liner (11), a first ultrasonic rod (13) and a second ultrasonic rod (14) are installed in the first inner liner (11), and the vibration frequency of the first ultrasonic rod (13) is different from the vibration frequency of the second ultrasonic rod (14).

9. The ultrasonic cross-flow extraction system according to claim 8, characterized in that: The ultrasonic extraction tank (1) further comprises a temperature regulating member, and the temperature regulating member is used to change the temperature of the ultrasonic extraction tank (1).

10. The ultrasonic cross-flow extraction system according to claim 1, characterized in that: The decolorizing and deodorizing tank (2) comprises a second inner liner (21) and a second outer shell (22); the second inner liner (21) is installed in the second outer shell (22); a through hole is provided in the second inner liner (21); and a decolorizing and deodorizing aid is installed in the second inner liner (21).

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