Nourishing bun technology with high nutrient component retention rate

Abstract

The invention relates to the technical field of nourishing steamed stuffed buns, in particular to a nourishing steamed stuffed bun technology with a high nutrient component retention rate, and the technology comprises the following steps: raw material pretreatment: raw materials comprise nutritional raw materials and functional raw materials; the method comprises the following steps: firstly, carrying out vacuum freeze drying on part of raw materials with the moisture content exceeding a certain value, pre-freezing at-50 DEG C for 3 hours, and then drying at-30 DEG C and the vacuum degree of 10Pa for 48 hours, so as to retain nutritional ingredients to the greatest extent; the nourishing bag prepared by the nourishing bag process disclosed by the invention enters the stomach, the polymer is shrunk in an acidic environment, and part of nutritional ingredients are slowly released; after entering the small intestine, the weak alkaline environment and the body temperature promote the polymer to swell, more nutritional ingredients are quickly released, and accurate and efficient nutrition supply is realized.

Description

Technical Field

[0001] The invention relates to the technical field of nourishing packs, in particular to a nourishing pack process with a high nutrient retention rate. Background Art

[0002] The nourishing pack is a compound nutritional product developed specifically to meet the nutritional needs of specific groups of people. Through scientific design and innovative functions, it is a health product that provides comprehensive, efficient and precise nutritional support to specific groups of people. It aims to improve the health status of the target population and meet their needs for nutrition and health. The preparation process of the nourishing pack will greatly affect the absorption efficiency and utilization effect of the nutrients. Due to the large difference in acidity and alkalinity between the human stomach and small intestine, the nourishing packs prepared by traditional technology have a low utilization rate of nutrients, and it is difficult to improve the utilization rate of nutrients in a targeted manner. Summary of the Invention

[0003] The object of the present invention is to provide a nourishing pack process with a high nutrient retention rate to solve the problems raised in the above background technology.

[0004] To achieve the above object, the present invention provides the following technical solution: a nourishing pack process with a high nutrient retention rate, the process comprising the following steps:

[0005] Step 1: Pretreatment of raw materials. The raw materials include nutritional raw materials and functional raw materials. First, some raw materials with a moisture content exceeding a certain value are vacuum freeze-dried, pre-frozen at -50°C for 3 hours, and then dried at -30°C and 10Pa vacuum for 48 hours to maximize the retention of nutrients. The dried raw materials are then pulverized to 800 mesh using a jet mill to increase the reaction area for subsequent processing.

[0006] Step 2: Mixing the raw materials. The raw materials crushed in step 1 and other raw materials are put into a three-dimensional mixer in proportion. The speed of the three-dimensional mixer is set to 20-30 r / min, and the mixing time is 40-60 minutes. During the mixing process, the temperature and humidity of the mixing environment are monitored in real time by a temperature and humidity sensor set in the mixer. The temperature is controlled at 15-20°C and the humidity is controlled at 30%-40% to ensure that the raw materials are not affected by temperature and humidity changes during the mixing process and to ensure the uniformity of the mixing;

[0007] Step 3: To construct the inductive release function, add N-isopropylacrylamide and acrylic acid in a molar ratio of 4:1 to a clean reaction vessel. Then add an appropriate amount of deionized water as a solvent to prepare a solution with a total monomer concentration of 15%. Add 0.5% potassium persulfate as an initiator and stir evenly to fully dissolve all components.

[0008] The reaction vessel was placed in a thermostatic water bath, and nitrogen was introduced for protection to exclude oxygen from the system and prevent oxidation of the monomers. The water bath temperature was set to 65° C., and the mixture was stirred and reacted at this temperature for 6 hours to allow N-isopropylacrylamide and acrylic acid to undergo a free radical polymerization reaction to form an N-isopropylacrylamide-acrylic acid copolymer. After the reaction, the obtained copolymer solution was slowly poured into a large amount of anhydrous ethanol, and the copolymer was precipitated. The precipitate was separated by centrifugation, and then the precipitate was washed three times with anhydrous ethanol to remove unreacted monomers and impurities.

[0009] Finally, the purified copolymer was placed in a vacuum drying oven and dried at 35°C and a vacuum degree of 0.09 MPa for 12 hours to obtain a nanoscale pH-temperature dual-sensitive polymer. The dried nanoscale pH-temperature dual-sensitive polymer was ground into a powder and passed through a 200-mesh sieve to make the particle size more uniform. The powder was then dissolved in a pH 7.0 phosphate buffer solution to prepare a 2% polymer solution for later use.

[0010] Step 4: Disperse the raw materials mixed in step 2 in a phosphate buffer solution with a pH of 7.0 and a temperature of 30° C. to form a uniform suspension; slowly add the prepared nanoscale pH-temperature dual-sensitive polymer solution to the suspension under stirring conditions, with a volume ratio of the polymer solution to the suspension of 1:5, and continue stirring during the addition process; during the reaction, the polymer and the raw materials are combined through electrostatic adsorption and chemical bonding. In order to monitor the reaction progress in real time, samples are taken every 30 minutes, and the particle size change is detected by a dynamic light scattering instrument to determine the adhesion of the polymer to the raw material surface; an infrared spectrometer is used to analyze the functional group changes of the sample to determine whether chemical bonding occurs. When the particle size is stable and the infrared spectrum shows a characteristic peak of a specific chemical bond, it indicates that the binding reaction is complete;

[0011] Step 5: The mixed solution in step 4 is separated by an ultrafiltration device to remove unbound polymer and excess buffer solution. The molecular weight cut-off of the ultrafiltration membrane is set to 10,000 Da, and the ultrafiltration operation is performed under a pressure of 0.1 MPa. The raw material particles loaded with the sensing material are then obtained by freeze drying.

[0012] Step six, forming the raw material particles loaded with the sensing material in step five to complete the preparation of the nourishing package.

[0013] Preferably, the nutritional raw materials include protein, vitamins and minerals; the protein includes cod protein peptide and bovine colostrum; the vitamins include natural vitamin C extracted from acerola cherry, vitamin E extracted from cereal germ, and B vitamins extracted from yeast; the minerals include calcium citrate and trace elements of zinc, magnesium, and selenium.

[0014] Preferably, the functional raw materials include herbal raw materials, special active substances and intestinal health substances; the herbal raw materials include ginseng, wolfberry, and Panax notoginseng; the special active substances include deep-sea fish oil and sodium hyaluronate, and the intestinal health substances include bifidobacteria, Lactobacillus acidophilus, oligofructose and inulin.

[0015] Preferably, in step six, the molding process specifically includes granulation, drying and coating.

[0016] Preferably, during the granulation process, wet granulation is adopted, hydroxypropyl methylcellulose and povidone K30 are selected as binders, and in a high-speed mixing granulator, the stirring blade speed is 120r / min, the cutting blade speed is 250r / min, the granulation time is 12 minutes, and particles with a particle size of 0.4-0.6mm are prepared.

[0017] Preferably, the drying process adopts fluidized bed drying with an air inlet temperature of 65°C, an air outlet temperature of 45°C, and a drying time of 18 minutes, so as to reduce the moisture content of the particles to about 2.5%, thereby avoiding the destruction of nutrients by high temperature.

[0018] Preferably, the coating process uses enteric acrylic resin L30D-55 as the main coating material, triethyl citrate as a plasticizer, and talc as an anti-sticking agent to prepare a coating solution with a concentration of 12%;

[0019] In the coating pot, the particles are rotated at a speed of 30r / min, and the coating liquid is evenly sprayed by a peristaltic pump. The coating temperature is 38°C and the coating weight gain is 4%, so that the nourishing bag is stable in gastric acid and quickly dissolves in the small intestine.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] When the nourishment pack prepared by the nourishment pack process of the present invention enters the stomach, the acidic environment causes the polymer to shrink, and some nutrients are slowly released; after entering the small intestine, the weakly alkaline environment and body temperature cause the polymer to swell, and more nutrients are quickly released, thereby achieving accurate and efficient nutrition supply and specifically improving the utilization rate of nutrients. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the process flow of the present invention. DETAILED DESCRIPTION

[0023] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] See also Figure 1 The present invention provides a technical solution: a nourishing pack process with a high nutrient retention rate, the process comprising the following steps:

[0025] Step 1: pretreatment of raw materials. Raw materials include nutritional raw materials and functional raw materials. Nutritional raw materials include protein, vitamin groups and minerals. Protein includes cod protein peptide and bovine colostrum. Cod protein peptide is powdery white granules. It is rich in various essential amino acids, and has small molecules and is easily absorbed. Bovine colostrum is rich in active ingredients such as immunoglobulins and growth factors, which can enhance immunity and promote physical development. Vitamin groups include natural vitamin C extracted from acerola cherry, vitamin E extracted from grain germ, and B vitamins extracted from yeast. Minerals include calcium citrate and trace elements such as zinc, magnesium, and selenium. Calcium citrate has a high calcium content and is easily absorbed, with little irritation to the gastrointestinal tract. At the same time, trace elements such as zinc, magnesium, and selenium are added. Zinc is involved in the synthesis of various enzymes, magnesium is essential for neuromuscular function, and selenium has antioxidant and anti-cancer effects.

[0026] Functional raw materials include herbal raw materials, special active substances and intestinal health substances; herbal raw materials include ginseng, wolfberry, and Panax notoginseng; special active substances include deep-sea fish oil and sodium hyaluronate, and intestinal health substances include bifidobacteria, lactobacillus acidophilus, oligofructose and inulin. First, some raw materials with a moisture content exceeding a certain value are vacuum freeze-dried, pre-frozen at -50°C for 3 hours, and then dried at -30°C and 10Pa vacuum for 48 hours to retain nutrients to the greatest extent; raw materials with a moisture content exceeding a certain value, such as ginseng, wolfberry, Panax notoginseng, bovine colostrum, etc., are adjusted according to specific circumstances to ensure that the raw materials can be dried and crushed. The dried raw materials are crushed to 800 mesh using a jet mill to increase the reaction area for subsequent processing;

[0027] Step 2: Mix the raw materials. Before mixing, microencapsulation technology and liposome encapsulation technology can be used to protect the nutrients from being destroyed by gastric acid, thereby improving their stability and bioavailability in the body. For example, for vitamin C, which is easily oxidized, gum arabic and β-cyclodextrin are mixed in a ratio of 3:2 as the wall material. Microencapsulation technology and liposome encapsulation technology are responsible for protecting the ingredients and optimizing absorption, and the induction release function construction technology is responsible for accurately locating the release site and controlling the release timing.

[0028] The raw materials crushed in step 1 and other raw materials are put into a three-dimensional mixer in proportion. The speed of the three-dimensional mixer is set to 20-30r / min, and the mixing time is 40-60 minutes. During the mixing process, the temperature and humidity of the mixing environment are monitored in real time by a temperature and humidity sensor installed in the mixer. The temperature is controlled at 15-20°C and the humidity is controlled at 30%-40% to ensure that the raw materials are not affected by temperature and humidity changes during the mixing process and to ensure the uniformity of the mixing.

[0029] Step 3: Build the induction release function:

[0030] N-isopropylacrylamide and acrylic acid are added to a clean reaction vessel. The monomer N-isopropylacrylamide is temperature-sensitive. At lower temperatures, its molecular chain is stretched and can form relatively stable interactions with the surrounding water molecules. However, when the temperature rises to close to human body temperature (37°C), its molecular chain will shrink, causing the overall structure of the polymer to change.

[0031] The acrylic acid monomer gives the polymer pH-sensitive properties. In an acidic environment, the carboxyl groups (-COOH) on acrylic acid are mostly in a protonated state, and the structure of the polymer is relatively tight. In an alkaline environment, the carboxyl groups will dissociate and become negatively charged carboxyl anions (-COO-), which will increase the electrostatic repulsion between the polymer molecular chains, thereby making the polymer structure stretch. Through the synthesis process, by controlling the ratio and polymerization method of the two monomers, this copolymer can undergo precise structural changes under the stimulation of different pH environments of the human gastrointestinal tract (pH 1.5-3.5 in the stomach, pH 6-8 in the small intestine) and body temperature (about 37°C), thereby achieving intelligent sensing release.

[0032] The molar ratio of N-isopropylacrylamide and acrylic acid is 4:1, and an appropriate amount of deionized water is added as a solvent to prepare a solution with a total monomer concentration of 15% (mass fraction). 0.5% (relative to the total weight of the monomers) of the initiator potassium persulfate is added and stirred evenly to fully dissolve all the components;

[0033] The reaction vessel was placed in a thermostatic water bath, and nitrogen was introduced for protection to exclude oxygen from the system and prevent oxidation of the monomers. The water bath temperature was set to 65° C., and the mixture was stirred and reacted at this temperature for 6 hours to allow N-isopropylacrylamide and acrylic acid to undergo a free radical polymerization reaction to form an N-isopropylacrylamide-acrylic acid copolymer. After the reaction, the obtained copolymer solution was slowly poured into a large amount of anhydrous ethanol, and the copolymer was precipitated. The precipitate was separated by centrifugation, and then the precipitate was washed three times with anhydrous ethanol to remove unreacted monomers and impurities.

[0034] Finally, the purified copolymer was placed in a vacuum drying oven and dried at 35°C and a vacuum degree of 0.09 MPa for 12 hours to obtain a nanoscale pH-temperature dual-sensitive polymer. The dried nanoscale pH-temperature dual-sensitive polymer was ground into a powder and passed through a 200-mesh sieve to make the particle size more uniform. The powder was then dissolved in a pH 7.0 phosphate buffer solution to prepare a 2% polymer solution for later use.

[0035] Step 4: Disperse the raw materials mixed in step 2 in a phosphate buffer solution with a pH of 7.0 and a temperature of 30° C. to form a uniform suspension; slowly add the prepared nanoscale pH-temperature dual-sensitive polymer solution to the suspension under stirring conditions, with a volume ratio of the polymer solution to the suspension of 1:5, and continue stirring during the addition process; during the reaction, the polymer and the raw materials are combined through electrostatic adsorption and chemical bonding. In order to monitor the reaction progress in real time, samples are taken every 30 minutes, and the particle size change is detected by a dynamic light scattering instrument to determine the adhesion of the polymer to the raw material surface; an infrared spectrometer is used to analyze the functional group changes of the sample to determine whether chemical bonding occurs. When the particle size is stable and the infrared spectrum shows a characteristic peak of a specific chemical bond, it indicates that the binding reaction is complete;

[0036] Step 5: The mixed solution in step 4 is separated by an ultrafiltration device to remove unbound polymer and excess buffer solution. The molecular weight cut-off of the ultrafiltration membrane is set to 10,000 Da, and the ultrafiltration operation is performed under a pressure of 0.1 MPa. The raw material particles loaded with the sensing material are then obtained by freeze drying.

[0037] Step six, forming the raw material particles loaded with the sensing material in step five to complete the preparation of the nourishing package.

[0038] In step six, the molding process specifically includes granulation processing, drying processing and coating processing.

[0039] During the granulation process, wet granulation is used. This involves uniformly mixing the drug powder with a suitable binder and then adding an appropriate amount of liquid to moisten the mixture, agglomerating the powder into granules with a certain strength. Compared to other granulation methods such as dry granulation and spray granulation, wet granulation effectively improves the material's flowability and compressibility, resulting in granules with uniform size and regular appearance, a compact internal structure, and excellent mechanical strength, making them suitable for subsequent drying and coating processes. Furthermore, by adjusting the binder type and dosage, as well as granulation parameters, the properties of the granules can be flexibly controlled to meet the needs of different products.

[0040] The present invention uses hydroxypropyl methylcellulose and povidone K30 as adhesives. Hydroxypropyl methylcellulose is a commonly used pharmaceutical polymer material with good water solubility, film-forming property and adhesion. It can form a viscous solution in water, bind the drug powder particles together, and form a stable particle structure. It has the advantages of high safety, non-toxicity, and no adverse effects on the human body. Povidone K30 is a synthetic polymer with strong adhesion and water solubility. It can quickly dissolve in water to form a uniform viscous solution, quickly bind the powder particles together during the granulation process, and promote the formation of particles. Finally, in a high-speed mixing granulator, the stirring blade speed is 120r / min, the cutting knife speed is 250r / min, and the granulation time is 12 minutes to produce particles with a particle size of 0.4-0.6mm.

[0041] The drying process uses fluidized bed drying with an air inlet temperature of 65°C, an air outlet temperature of 45°C, and a drying time of 18 minutes, which reduces the moisture content of the particles to about 2.5% and avoids the destruction of nutrients by high temperature.

[0042] Enteric-soluble acrylic resin L30D-55 was selected as the main coating material for coating, triethyl citrate was added as a plasticizer, and talc powder was added as an anti-sticking agent to prepare a coating solution with a concentration of 12%.

[0043] In the coating pot, the particles are rotated at a speed of 30r / min, and the coating liquid is evenly sprayed by a peristaltic pump. The coating temperature is 38°C and the coating weight gain is 4%, so that the nourishing bag is stable in gastric acid and quickly dissolves in the small intestine.

[0044] After the coating process is completed, the preparation of the coated particles of the nourishing package is basically completed, and then packaging can be carried out. During packaging, the coated particles are placed into blisters in a Class 100 clean workshop, with a heat sealing temperature of 160°C and a heat sealing time of 1.5 seconds. After sealing, the blisters are packed in boxes, and a product manual is included in the box, indicating the ingredients, efficacy, method of consumption, shelf life and other information.

[0045] The in vitro simulated release experiment of the nutrient pack prepared by the nutrient pack process of the present invention is as follows:

[0046] First, a hydrochloric acid-sodium chloride buffer solution with a pH of 2.0 was prepared to simulate the acidic environment of the stomach. The nutrient pack particles were placed in this buffer solution and a release experiment was conducted in a 37°C constant temperature oscillating water bath (oscillation speed 100 r / min). Samples were taken every 30 minutes, and the nutrient content released in the samples was measured using high-performance liquid chromatography or ultraviolet spectrophotometry. A nutrient release curve was then plotted under the gastric environment.

[0047] To simulate the small intestinal environment, a phosphate buffer solution with a pH of 7.5 was prepared to simulate the alkaline environment of the small intestine. After the gastric environment simulation experiment, the nutrient pack particles were transferred to this buffer solution and the release experiment was also carried out in a 37°C constant temperature oscillating water bath (oscillation speed 100 r / min). Samples were collected and tested at the same time intervals as above, and the nutrient release curve in the small intestinal environment was plotted.

[0048] Release curves were analyzed under simulated gastric and small intestinal environments, and the cumulative release rates of nutrients at different time periods were calculated. Comparative analysis showed that the cumulative release rate of nutrients in the gastric environment did not exceed 30% within 2 hours, while the cumulative release rate in the small intestinal environment reached over 80% within 2 hours, achieving controlled release.

[0049] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A nourishing pack process with high nutrient retention rate, characterized in that: The process includes the following steps: Step 1: Pretreatment of raw materials. The raw materials include nutritional raw materials and functional raw materials. First, some raw materials with a moisture content exceeding a certain value are vacuum freeze-dried, pre-frozen at -50°C for 3 hours, and then dried at -30°C and 10Pa vacuum for 48 hours to maximize the retention of nutrients. The dried raw materials are then pulverized to 800 mesh using a jet mill to increase the reaction area for subsequent processing. Step 2: Mixing the raw materials. The raw materials crushed in step 1 and other raw materials are put into a three-dimensional mixer in proportion. The speed of the three-dimensional mixer is set to 20-30 r / min, and the mixing time is 40-60 minutes. During the mixing process, the temperature and humidity of the mixing environment are monitored in real time by a temperature and humidity sensor set in the mixer. The temperature is controlled at 15-20°C and the humidity is controlled at 30%-40% to ensure that the raw materials are not affected by temperature and humidity changes during the mixing process and to ensure the uniformity of the mixing; Step 3: To construct the inductive release function, add N-isopropylacrylamide and acrylic acid in a molar ratio of 4:1 to a clean reaction vessel. Then add an appropriate amount of deionized water as a solvent to prepare a solution with a total monomer concentration of 15%. Add 0.5% potassium persulfate as an initiator and stir evenly to fully dissolve all components. The reaction vessel was placed in a thermostatic water bath, and nitrogen was introduced for protection to exclude oxygen from the system and prevent oxidation of the monomers. The water bath temperature was set to 65° C., and the mixture was stirred and reacted at this temperature for 6 hours to allow N-isopropylacrylamide and acrylic acid to undergo a free radical polymerization reaction to form an N-isopropylacrylamide-acrylic acid copolymer. After the reaction, the obtained copolymer solution was slowly poured into a large amount of anhydrous ethanol, and the copolymer was precipitated. The precipitate was separated by centrifugation, and then the precipitate was washed three times with anhydrous ethanol to remove unreacted monomers and impurities. Finally, the purified copolymer was placed in a vacuum drying oven and dried at 35°C and a vacuum degree of 0.09 MPa for 12 hours to obtain a nanoscale pH-temperature dual-sensitive polymer. The dried nanoscale pH-temperature dual-sensitive polymer was ground into a powder and passed through a 200-mesh sieve to make the particle size more uniform. The powder was then dissolved in a pH 7.0 phosphate buffer solution to prepare a 2% polymer solution for later use. Step 4: Disperse the raw materials mixed in step 2 in a phosphate buffer solution with a pH of 7.0 and a temperature of 30° C. to form a uniform suspension; slowly add the prepared nanoscale pH-temperature dual-sensitive polymer solution to the suspension under stirring conditions, with a volume ratio of the polymer solution to the suspension of 1:5, and continue stirring during the addition process; during the reaction, the polymer and the raw materials are combined through electrostatic adsorption and chemical bonding. In order to monitor the reaction progress in real time, samples are taken every 30 minutes, and the particle size change is detected by a dynamic light scattering instrument to determine the adhesion of the polymer to the raw material surface; an infrared spectrometer is used to analyze the functional group changes of the sample to determine whether chemical bonding occurs. When the particle size is stable and the infrared spectrum shows a characteristic peak of a specific chemical bond, it indicates that the binding reaction is complete; Step 5: The mixed solution in step 4 is separated by an ultrafiltration device to remove unbound polymer and excess buffer solution. The molecular weight cut-off of the ultrafiltration membrane is set to 10,000 Da, and the ultrafiltration operation is performed under a pressure of 0.1 MPa. The raw material particles loaded with the sensing material are then obtained by freeze drying. Step six, forming the raw material particles loaded with the sensing material in step five to complete the preparation of the nourishing package.

2. A nourishing pack process with high nutrient retention rate according to claim 1, characterized in that: The nutritional raw materials include protein, vitamin groups and minerals; the protein includes cod protein peptide and bovine colostrum; the vitamin groups include natural vitamin C extracted from acerola cherry, vitamin E extracted from grain germ, and B vitamins extracted from yeast; the minerals include calcium citrate and trace elements of zinc, magnesium, and selenium.

3. The nourishing pack process with high nutrient retention rate according to claim 1, characterized in that: The functional raw materials include herbal raw materials, special active substances and intestinal health substances; the herbal raw materials include ginseng, wolfberry, and Panax notoginseng; the special active substances include deep-sea fish oil and sodium hyaluronate, and the intestinal health substances include bifidobacteria, Lactobacillus acidophilus, oligofructose and inulin.

4. The nourishing pack process with high nutrient retention rate according to claim 1, characterized in that: In step six, the molding process specifically includes granulation, drying and coating.

5. A nourishing pack process with high nutrient retention rate according to claim 4, characterized in that: During the granulation process, wet granulation is adopted, hydroxypropyl methylcellulose and povidone K30 are selected as binders, and in a high-speed mixing granulator, the stirring blade speed is 120 r / min, the cutting blade speed is 250 r / min, and the granulation time is 12 minutes to prepare granules with a particle size of 0.4-0.6 mm.

6. The nourishing pack process with high nutrient retention rate according to claim 4, characterized in that: The drying process adopts fluidized bed drying, with an air inlet temperature of 65° C., an air outlet temperature of 45° C., and a drying time of 18 minutes, reducing the moisture content of the particles to about 2.5%, thereby avoiding the destruction of nutrients by high temperature.

7. The process for a nourishing pack with high nutrient retention rate according to claim 4, characterized in that: The coating process uses enteric acrylic resin L30D-55 as the main coating material, adds triethyl citrate as a plasticizer, and talc as an anti-sticking agent to prepare a coating solution with a concentration of 12%; In the coating pot, the particles are rotated at a speed of 30r / min, and the coating liquid is evenly sprayed by a peristaltic pump. The coating temperature is 38°C and the coating weight gain is 4%, so that the nourishing bag is stable in gastric acid and quickly dissolves in the small intestine.

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