Whitening and mothproof toothpaste and preparation method thereof

Abstract

The invention relates to whitening and mothproof toothpaste and a preparation method thereof. Comprising a mothproof agent, a low-wear friction agent, a metal chelating agent and protease, and the mothproof agent is formed by mixing fluoride and polyhydric alcohol according to the mass ratio of 1: 15-1: 30. According to the present invention, the fluoride and the xylitol are synergistically proportioned, such that on the premise of the reduction of the fluoride consumption, the mothproof effect is good, the fluorine poisoning risk is reduced, the safety is good, the low-wear friction agent is combined with the metal chelating agent and the protease so as to achieve the removal of the pigment on the tooth surface, and the whitening effect is good.

Description

Technical Field

[0001] The present invention relates to the field of daily cosmetics, in particular to a whitening and anti-caries toothpaste and a preparation method thereof. Background Art

[0002] Currently, toothpastes on the market are mainly divided into two categories: whitening and anti-caries. Whitening toothpaste removes pigmentation on the tooth surface by adding ingredients such as titanium dioxide and silicon dioxide, while anti-caries toothpaste uses ingredients such as fluoride to enhance the tooth's resistance to acid erosion and reduce the occurrence of dental caries. However, existing toothpaste products often fail to achieve these functions at the same time and generally suffer from the following technical problems: 1. Current whitening toothpastes mostly use high-abrasive abrasives such as calcium carbonate and silica, or chemical bleaching agents such as peroxide. Long-term use can damage tooth enamel or irritate gums and cause tooth sensitivity. Although some products have tried to use low-abrasive abrasives such as hydrated silica as substitutes, their compatibility with fluoride and plant active ingredients is insufficient, which can easily lead to paste stratification or ingredient inactivation.

[0003] 2. Mainstream anti-cavity toothpastes rely heavily on fluoride to prevent caries, but long-term use carries the risk of fluoride overdose. Furthermore, fluoride can easily interact with whitening ingredients (such as abrasives and proteases). For example, fluoride ions are adsorbed by calcium carbonate abrasives, reducing their anti-cavity effectiveness. High fluoride concentrations can inhibit protease activity, weakening whitening results. This conflict makes it difficult for existing products to achieve both high-efficiency anti-cavity and gentle whitening.

[0004] 3. Existing toothpastes containing fluoride or enzymes often neglect gum care and can even exacerbate gum problems due to irritating ingredients. While a few products contain single plant extracts for antibacterial effects, their anti-inflammatory effects are limited.

[0005] The main problems faced by existing technologies: There is currently a lack of a composite functional toothpaste on the market that can effectively whiten and safely prevent tooth decay while avoiding the risk of tooth wear and excessive fluoride intake. Existing solutions and their limitations: Most of the existing whitening and anti-caries composite toothpastes on the market simply mix whitening and anti-caries ingredients, which are not ideal and there is a problem of reduced effect due to interactions between ingredients. In addition, these products fail to take safety into account while achieving whitening and anti-caries, such as excessive use of abrasives and fluorides. The development of an efficient, safe toothpaste with both whitening and anti-caries functions faces the challenge of formula balance, that is, how to make the various ingredients work synergistically, avoid mutual interference, and ensure safety to the human body. The continuous growth of market demand and the increasing attention to oral health provide a broad space for innovation. Summary of the Invention

[0006] The object of the present invention is to provide a whitening and anti-caries toothpaste which is low in fluorine, highly effective in preventing dental caries, whitens teeth with low damage, and also has gum care functions.

[0007] Another object of the present invention is to provide a method for preparing the toothpaste.

[0008] In order to achieve the above-mentioned purpose of the invention and solve the problems existing in the background technology, the present invention adopts the following technical solution: a whitening and anti-caries toothpaste, characterized by comprising an anti-caries agent, a low-wear friction agent, a metal chelating agent and a protease, wherein the anti-caries agent is a mixture of fluoride and polyol in a mass ratio of 1:15 to 1:30.

[0009] Through the compounding of mothproofing agents and the synergistic effect with low-wear friction agents, metal chelating agents and proteases, high-efficiency moth prevention and low-damage whitening are achieved.

[0010] Furthermore, the fluoride is sodium fluoride or stannous fluoride, and the polyol is xylitol.

[0011] Further limit the types of fluoride and polyols to enhance the anti-moth effect.

[0012] Furthermore, it also includes a plant extract composition, which is a combination of at least two of Platycladus orientalis leaf extract, Camellia sinensis leaf extract, Phyllanthus emblica extract, Glechoma longituba extract and Persimmon fruit extract.

[0013] Adding plant extract composition can enhance the antibacterial effect of toothpaste and solve gum-related problems.

[0014] Furthermore, a whitening and anti-caries toothpaste comprises the following components in percentage by mass: Moisturizer: 40-65%; Low wear friction agent: 10-20%; Moth repellent: 5-10%; Foaming agent: 1-3%; Plant extract composition: 0.03-0.5%; Papain: 0.05-0.3%; Metal chelators: 0.1-1%; Thickener: 0.5-2%; Other preparation excipients: 0.2-1%, including sweeteners, preservatives and flavors; Water: Balance.

[0015] Clarify the mass percentage range of each component to ensure a balance between paste consistency, cleanliness and efficacy of active ingredients.

[0016] Furthermore, the low-wear friction agent is hydrated silica.

[0017] Hydrated silica is used as a low-wear friction agent to reduce the risk of enamel damage and improve safety.

[0018] Furthermore, the metal chelating agent is sodium phytate or zinc citrate or a combination of the two.

[0019] Sodium Phytate / Zinc Citrate acts as a chelating agent to chelate pigmentation.

[0020] Furthermore, a whitening and anti-caries toothpaste includes the following components in percentage by mass: 0.23% sodium fluoride, 6% xylitol, 54% sorbitol, 2.75% polyethylene glycol-8, 13.5% hydrated silica, 0.5% sodium phytate, 0.3% zinc citrate, 0.12% papain, 1.8% sodium lauryl sulfate, 0.03% orientalis leaf extract, 0.12% Australian tea leaf extract, 0.01% emblica fruit extract, 0.012% angelica officinalis extract, 0.12% persimmon fruit extract, 0.68% disodium dihydrogen pyrophosphate, 0.45% cellulose gum, 0.4% xanthan gum, 1.05% flavor, 0.18% saccharin sodium, 0.15% PEM preservative, and the balance is water.

[0021] Through precise proportioning, the synergistic effect of each ingredient is optimized to achieve comprehensive effects of anti-caries, whitening and anti-inflammatory.

[0022] The present invention also discloses a method for preparing whitening toothpaste, comprising the following steps: (1) Phase separation premixing: Add the solvent, sweetener and preservative into the liquid phase premixing pot and stir evenly to obtain phase A; Add the moisturizer to the liquid phase premixing pot and stir evenly to obtain phase B; Add fluoride, xylitol, low-damage friction agent, metal chelating agent, protease, plant extract composition and thickener into the liquid phase premixing pot and stir evenly to obtain phase C; (2) Vacuum dispersion: Under vacuum conditions of -0.08MPa to -0.1MPa, phase A, phase B, and phase C are sucked into the emulsifying pot in sequence, and the temperature is controlled at ≤45°C for high-speed dispersion and homogenization; (3) Add essence and homogenize the mixture.

[0023] The combination of phase separation premixing and low-temperature vacuum dispersion process avoids the inactivation of active ingredients (such as papain) and ensures that the paste is uniform and stable.

[0024] Furthermore, during the C phase addition stage, high-speed dispersion is started after the vacuum degree reaches 0.094 MPa, and the homogenization speed is 1000-1500 rpm.

[0025] High-speed dispersion under a specific vacuum degree (≥0.094MPa) improves the uniformity of powder dispersion and reduces agglomeration.

[0026] A whitening and anti-caries toothpaste is used to simultaneously achieve teeth whitening, anti-caries and relief of gingivitis.

[0027] The beneficial effects of this application: 1. Through the synergistic ratio of fluoride and xylitol (mass ratio 1:15 to 1:30), while reducing the amount of fluoride used, the anti-moth effect is better and the risk of fluoride poisoning is reduced. It is especially suitable for children and sensitive people.

[0028] 2. Use low-wear abrasives in combination with metal chelators and proteases to remove tooth surface pigments and achieve good whitening effects. At the same time, the enamel wear value is low, avoiding dentin sensitivity caused by long-term use.

[0029] 3. Use a compound plant extract composition to effectively inhibit inflammatory factors and reduce the incidence of gum problems. DETAILED DESCRIPTION

[0030] The present application is further described below through specific embodiments, but the protection scope of the present application is not limited to the embodiments.

[0031] Example 1: 1 kg of toothpaste was prepared using the following components in the following mass percentages: Table 1: Example 1 formulation The mass ratio of sodium fluoride to xylitol in Table 1 is approximately 1:26.

[0032] Preparation process: 1. Weigh and prepare each component according to the formula in Table 1; 2. Add phase A into the liquid phase premixing pot and stir at room temperature for 2 minutes until dissolved; 3. Add phase B into the liquid phase premixing pot and stir at room temperature for 1 minute until they are dissolved; 4. Add phase C into the powder phase premix pot and stir at room temperature for 2 minutes until dispersed; 5. Start the vacuum pump and chilled water network and apply vacuum. When the vacuum reaches -0.08, start the scraper agitator. Turn off the vacuum pump and aspirate phase A at room temperature into the vacuum pot for agitation. After aspiration is complete, start the vacuum pump again. When the vacuum reaches -0.08, start the high-speed disperser. Turn off the vacuum pump and aspirate phase B at room temperature into the vacuum pot for dispersion. After aspiration is complete, start the vacuum pump again. When the vacuum reaches -0.08, turn off the vacuum pump and aspirate phase C at room temperature into the vacuum pot for dispersion. After aspiration of phase C, when the vacuum reaches -0.094, increase the homogenizer speed to 1300 rpm and homogenize for 30 minutes. Keep the temperature ≤45°C throughout the entire process. Add the flavoring and continue vacuum homogenization for 15 minutes. Turn off the high-speed disperser, scraper agitation, and vacuum pump. Release the air to break the vacuum. Discharge the material when no bubbles are present. Then, turn off the chilled water network. Open the discharge valve and start the discharge pump. After discharging is complete, turn off the discharge pump first and then the discharge valve to obtain a whitening and anti-caries toothpaste paste.

[0033] Example 2: Preparation of 1 kg of toothpaste Formula adjustment: (by mass percentage) 1. Moisturizer: sorbitol 60%, polyethylene glycol-8 3%; 2. Mothproofing agent: sodium fluoride 0.3%, xylitol 5.4%, mass ratio 1:18; 3. Hydrated silica 13%, sodium phytate 0.6%, zinc citrate 0.3%; 4. Plant extract composition: Platycladus orientalis leaf extract 0.1%, Camellia sinensis leaf extract 0.2%.

[0034] The remaining components are the same as those in Example 1, and the balance is made up with water.

[0035] The preparation method is the same as that in Example 1.

[0036] Example 3: Preparation of 1 kg toothpaste Formula adjustment: (by mass percentage) 1. Moisturizer: sorbitol 38%, polyethylene glycol-8 4%; 2. Mothproofing agent: sodium fluoride 0.2%, xylitol 6%, mass ratio 1:30; 3. Hydrated silica 18%, sodium phytate 0.5%, zinc citrate 0.3%; 4. Plant extract composition: Platycladus orientalis leaf extract 0.5%, Camellia sinensis leaf extract 0.12%, Emblica officinalis extract 0.05%.

[0037] The remaining components are the same as those in Example 1, and the balance is made up with water.

[0038] The preparation method is the same as that in Example 1.

[0039] Comparative Example 1: Preparation of 1 kg toothpaste Formula adjustment: (by mass percentage) 1. Moth repellent: sodium fluoride 0.8% xylitol 5.43%, the mass ratio of the two is 1:6.8; The remaining components are the same as in Example 1, and the balance is made up with water; The preparation method is the same as that in Example 1.

[0040] Comparative Example 2: Preparation of 1 kg toothpaste Formula adjustment: (by mass percentage) 1. Moth repellent: sodium fluoride 0.13% xylitol 6.1%, the mass ratio of the two is 1:47; The remaining components are the same as in Example 1, and the balance is made up with water; The preparation method is the same as that in Example 1.

[0041] Comparative Example 3: Preparation of 1 kg toothpaste Formula adjustment: (by mass percentage) 1. Moth repellent: Use 0.5% sodium fluoride.

[0042] The remaining components are the same as in Example 1, and the balance is made up with water; The preparation method is the same as that in Example 1.

[0043] Comparative Example 4: Recipe Adjustment: 1. Silicon dioxide was used to replace the hydrated silica in the formula of Example 1, and the mass percentage remained unchanged at 13.5%.

[0044] The remaining components and preparation method are the same as those in Example 1.

[0045] Comparative Example 5: Except for sodium phytate, zinc citrate and papain in Example 1, the remaining components and preparation method are the same as those in Example 1.

[0046] Comparative Example 6: Except for removing the hydrated silica in Example 1, the remaining components and the preparation method are the same as those in Example 1.

[0047] Comparative Example 7: All the plant extract compositions in Example 1 were removed, and the remaining components and preparation methods were the same as in Example 1.

[0048] Test 1: Anti-moth effect test 1. Experimental Purpose Verify the moth-proofing effect of different compound ratios of sodium fluoride and xylitol, compare with single fluoride and control ratios beyond the ratio range, and clarify the optimal moth-proofing agent ratio range.

[0049] 2. Test Sample Grouping The toothpastes obtained in Examples 1, 2, 3 and Comparative Examples 1, 2, 3 were grouped and tested.

[0050] 3. In vitro enamel acid erosion resistance test (hydroxyapatite HA block method) 1. Sample preparation Hydroxyapatite (HA) blocks of Φ5 mm × 3 mm were prepared, and the microhardness was controlled at 450 ± 20 HV, with 10 pieces in each group.

[0051] Pretreatment: HA blocks were immersed in toothpaste slurry of each group (1 g toothpaste + 10 mL deionized water mixed) and shaken at 37°C for 30 minutes.

[0052] 2. Acid etching Etching solution: pH = 4.5 lactic acid buffer, changed daily for 7 days.

[0053] Detection indicators: Microhardness retention rate: The hardness of the HA block was measured before and after acid etching, and the retention rate (%) was calculated; Fluoride ion release: The free fluoride concentration (ppm) in the pretreatment solution was determined by ICP-MS; Fluoride ion adsorption capacity: After the acid etching, the surface of the HA block was cleaned with deionized water, and the HA block was dissolved by microwave digestion instrument. The total fluoride content was determined by ICP-MS, and the fluoride adsorption capacity per unit area (μg / cm 2 ).

[0054] 4. Experimental Data Note: * indicates that the free fluorine concentration exceeds the GB8372-2017 standard (0.15ppm) or the fluorine adsorption amount is significantly lower than that of the invention group.

[0055] 5. Data Analysis 1. Comparison of hardness retention rate The hardness retention rates of the invention groups (Examples 1-3) were all greater than 89%, indicating that the compound system could still effectively protect tooth enamel at low fluoride concentrations.

[0056] Although the fluorine adsorption capacity of Comparative Example 1 (high fluorine, low xylitol) is close to that of the invention group, the free fluorine exceeds the standard, posing a safety risk; the fluorine adsorption capacity of Comparative Example 2 (low fluorine, high xylitol) is significantly reduced due to insufficient fluorine content (p<0.05).

[0057] 2. Fluoride ion adsorption mechanism The fluorine adsorption capacity of the invention group (2.6-3.1μg / cm 2 ), compared with comparative example 2 (1.8 μg / cm 2 ) increased by 44%-72%, indicating that xylitol promoted the penetration of fluoride ions into the HA lattice through complexation, thereby improving the anti-moth efficiency.

[0058] Comparative Example 3 Fluorine adsorption (2.2 μg / cm 2 ) was lower than that of the invention group, which confirmed that the synergistic effect of xylitol can enhance the binding ability of fluoride ions and minerals.

[0059] 3. Security Verification The free fluorine concentration of the invention group was ≤0.15ppm, which was in line with the national standard. Comparative Examples 1 and 3 may cause the risk of fluorosis due to excessive free fluorine, while Comparative Example 2 had a reduced anti-moth effect due to insufficient fluorine adsorption.

[0060] From the above experiments, it can be seen that when the mass ratio of sodium fluoride to xylitol is in the range of 1:15 to 1:30, high fluorine adsorption capacity (≥2.6 μg / cm 2 ), low free fluoride (≤0.15ppm) and high hardness retention rate (≥89%), which solves the safety risks of traditional high-fluoride toothpaste while ensuring the anti-caries effect.

[0061] Test 2: Low-loss whitening effect test 1. Experimental Purpose The whitening efficiency and low wear properties of the "hydrated silica + sodium phytate + zinc citrate + papain" composite system of the present invention were verified.

[0062] 2. Test Sample Grouping The toothpastes obtained in Examples 1, 2, 3 and Comparative Examples 4, 5, 6 were tested in groups.

[0063] 3. Test Method: In Vitro Pigment Clearance and Wear Test 1. Pigment clearance rate experiment Preparation of artificial pigment film: HA sheets were soaked in a mixture of coffee and tea stains (volume ratio 1:1) and dried at 60°C for 24 hours to form a uniform pigment deposition layer.

[0064] Cleaning experiment: Each group of toothpaste slurry (1 g / 10 mL deionized water) was ultrasonically vibrated to clean the pigment sheets for 5 minutes, once a day for 7 days.

[0065] The absorbance (A value) at a wavelength of 450 nm was measured using an ultraviolet spectrophotometer to calculate the pigment clearance rate: 2. Wear value test Friction and wear simulation: The toothpaste slurry was rubbed against the HA sheet 1000 times using a grinder (load 300 g, rotation speed 100 rpm), and the wear depth (μm) was measured using a laser confocal microscope.

[0066] RDA value of abrasives: Referring to GB / T29678-2013 standard, the calcium phosphate rotating disk method was used to determine the relative dentin wear value of abrasives.

[0067] 4. Experimental Data Note: * indicates significant difference compared with Example 1 (p<0.05).

[0068] 5. Data Analysis 1. Whitening efficiency comparison: The pigment removal rate of Example 1 reached 86.7%, which was significantly higher than that of Comparative Examples 5 and 6, proving that the synergistic effect of the metal chelator (sodium phytate / zinc citrate) and papain is the core of whitening, and the absence of any one component leads to a decrease in efficiency.

[0069] Although the removal rate of Comparative Example 4 (silicon dioxide friction agent) is close to that of Example 1, the wear depth is 2.4 times that of Example 1, and the RDA value exceeds the standard (>250), confirming the limitations of traditional high-wear friction agents.

[0070] 2. Wear control comparison: The wear depth of Example 1 (7.8 μm) is significantly lower than that of Comparative Example 4 (18.5 μm), and higher than that of Comparative Example 6 (no abrasive), but the removal rate is higher, indicating that hydrated silica can still provide effective physical polishing at a low RDA value (120) to avoid excessive wear.

[0071] Although the comparative example 5 (no chelating agent + enzyme) has low abrasion, the pigment removal rate is insufficient, indicating that simple physical friction cannot effectively remove pigments and requires the coordinated action of chemical chelation and enzymatic hydrolysis.

[0072] Test 3: Antibacterial and anti-inflammatory test 1. Experimental Purpose Verify the alleviating effect and antibacterial effect of the plant extract composition in this application on gingivitis.

[0073] 2. Experimental Grouping Example 1, Example 2, Example 3, Comparative Example 7 and commercially available fluoride-containing toothpaste without plant extracts.

[0074] 3. In vitro antibacterial test (inhibition of Streptococcus mutans) 1. Methods: Preparation of bacterial solution: Culture Streptococcus mutans to OD600 = 0.5 and spread on blood agar plates.

[0075] Drug treatment: Filter paper pieces soaked with toothpaste slurry (1 g / 10 mL) of each group were attached to plates and incubated at 37°C for 24 hours.

[0076] Detection index: Inhibition zone diameter (mm), diameter > 10mm is considered effective inhibition.

[0077] 2. Data Group Diameter of inhibition zone (mm) Example 1 15.2±1.8 Example 2 14.5±1.2 Example 3 13.6±1.3 Comparative Example 7 8.2±0.9* Commercially available toothpaste 9.8±1.1* Note: * indicates significant difference compared with Example 1 (p<0.05).

[0078] IV. In vivo anti-inflammatory test (rat gingivitis model) 1. Methods Model establishment: Rats were orally inoculated with Porphyromonas gingivalis and fed a high-sugar diet daily to induce gingivitis.

[0079] Group processing: The rats of Example 1, Example 2, Example 3, Comparative Example 7 and a commercially available fluoride-containing toothpaste without plant extracts were smeared with the corresponding toothpaste (0.1 g / toothpaste) daily for 2 weeks.

[0080] Detection indicators: Gingival index (GI): 0 = normal, 3 = severe redness, swelling and bleeding.

[0081] Inflammatory factors: ELISA was used to detect the levels of IL-6 and TNF-α in gingival crevicular fluid.

[0082] 2. Data 5. Data Analysis 1. Antibacterial effect: The inhibition zones of Examples 1, 2, and 3 are significantly larger than those of Comparative Example 7 and the commercially available toothpaste without plant extracts, and Example 1 containing all plant extract compositions has the best antibacterial effect, indicating that multiple plant extract compositions can enhance the antibacterial effect through synergistic effects.

[0083] 2. Anti-inflammatory and synergistic effect: The IL-6 and TNF-α levels of Examples 1, 2, and 3 were significantly lower than those of Comparative Example 7 and commercially available toothpaste without the extract, and Example 1 had the best effect, confirming that the compound system can inhibit the expression of inflammatory factors and relieve gingival redness, swelling, and bleeding, and its effect is better than that of plant extract compositions or commercially available products.

Claims

1. A whitening and anti-caries toothpaste, characterized in that: The invention comprises a mothproofing agent, a low-wear friction agent, a metal chelating agent and a protease. The mothproofing agent is a mixture of fluoride and polyol in a mass ratio of 1:15 to 1:

30.

2. A whitening and anti-caries toothpaste according to claim 1, characterized in that: The fluoride is sodium fluoride or stannous fluoride, and the polyol is xylitol.

3. A whitening and anti-caries toothpaste according to claim 1, characterized in that: It also includes a plant extract composition, which is a combination of at least two of Platycladus orientalis leaf extract, Camellia sinensis leaf extract, Phyllanthus emblica fruit extract, Glechoma longituba extract and Persimmon fruit extract.

4. A whitening and anti-caries toothpaste according to claim 1, characterized in that: The composition comprises the following components in percentage by weight: moisturizing agent: 40-65%; Low wear friction agent: 10-20%; Moth repellent: 5-10%; Foaming agent: 1-3%; Plant extract composition: 0.03-0.5%; Papain: 0.05-0.3%; Metal chelators: 0.1-1%; Thickener: 0.5-2%; Other preparation excipients: 0.2~1%, including sweeteners, preservatives and flavors; Water: Balance.

5. A whitening and anti-caries toothpaste according to claim 1, characterized in that: The low-wear friction agent is hydrated silica.

6. A whitening and anti-caries toothpaste according to claim 1, characterized in that: The metal chelating agent is sodium phytate or zinc citrate or a combination of the two.

7. A whitening and anti-caries toothpaste according to claim 4, characterized in that: The following components are included in mass percentage: 23% sodium fluoride, 6% xylitol, 54% sorbitol, 2.75% polyethylene glycol-8, 13.5% hydrated silica, 0.5% sodium phytate, 0.3% zinc citrate, 0.12% papain, 1.8% sodium lauryl sulfate, 0.03% orientalis leaf extract, 0.12% camellia sinensis leaf extract, 0.01% emblica fruit extract, 0.012% gypsophila extract, 0.12% persimmon fruit extract, 0.68% disodium dihydrogen pyrophosphate, 0.45% cellulose gum, 0.4% xanthan gum, 1.05% flavor, 0.18% sodium saccharin, 0.15% PEM preservative, balance water.

8. The method for preparing a whitening toothpaste according to any one of claims 1 to 7, wherein: The steps include: (1) Phase separation premixing: Add the solvent, sweetener and preservative into the liquid phase premixing pot and stir evenly to obtain phase A; Add the moisturizer to the liquid phase premixing pot and stir evenly to obtain phase B; Add fluoride, xylitol, low-damage friction agent, metal chelating agent, protease, plant extract composition and thickener into the liquid phase premixing pot and stir evenly to obtain phase C; (2) Vacuum dispersion: Under vacuum conditions of -0.08MPa to -0.1MPa, phase A, phase B, and phase C are sucked into the emulsifying pot in sequence, and the temperature is controlled at ≤45°C for high-speed dispersion and homogenization; After adding essence, homogenize and discharge the material.

9. The method for preparing a whitening and anti-caries toothpaste according to claim 8, characterized in that: During the phase C addition stage in step (2), high-speed dispersion is started when the vacuum degree reaches 0.094 MPa, and the homogenization speed is 1000-1500 rpm.

10. Use of the whitening and anti-caries toothpaste according to any one of claims 1 to 7 for simultaneously achieving teeth whitening, anti-caries and relief of gingivitis.

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