Soothing anti-allergy composition and application

Abstract

The invention relates to the technical field of cosmetics, and particularly discloses a soothing and anti-allergy composition and application. The soothing and anti-allergy composition comprises a hairyvein agrimony extract, a purslane extract, nicotinamide, shale oil sodium sulfonate, a rhodiola rosea root extract and an artemisia kuwui leaf extract. Meanwhile, the soothing and anti-allergy essence can be prepared from the compound serving as a functional component, a humectant, a chelating agent, a thickening agent, a solubilizer and deionized water. The soothing and anti-allergy composition has the advantages of being good in soothing and anti-allergy effect, mild and non-irritating, and soothing and anti-allergy essence prepared from the soothing and anti-allergy composition also shows excellent soothing and anti-allergy ability.

Description

Technical Field

[0001] The present invention relates to the field of skin care products, and in particular to a soothing and anti-allergic composition and its application. Background Art

[0002] With the development of the economy and society, consumer demand for functional skincare products is growing. Soothing skincare products are crucial for alleviating skin irritation and repairing damaged skin. While traditional soothing ingredients are primarily chemical, plant extracts are increasingly gaining popularity due to their naturalness and effectiveness.

[0003] However, existing soothing products with plant extracts often have a single active ingredient, addressing only skin sensitivity caused by a specific allergy trigger or a specific category of allergy triggers. The causes of skin sensitivity are complex, often caused by a combination of factors. Consequently, existing soothing extract products have limited soothing and anti-allergic effects in practical applications.

[0004] In addition, compound soothing products have been launched on the market to address this problem, but most of these compound products are stacked products with multiple functional ingredients added. Such products may contain ingredients that are harmful to specific skin types, or the ingredient content exceeds the standard, the ingredients are improperly selected, and the ratio is unreasonable, leading to adverse reactions after use, which will aggravate skin sensitivity problems.

[0005] In response to the above-mentioned related technologies, the inventors believe that it is necessary to develop a soothing and anti-allergic composition based on plant extracts that can effectively solve skin sensitivity problems and is mild and non-irritating. Summary of the Invention

[0006] In order to solve the technical defects of the prior art, the present application provides a soothing anti-allergic composition and its application.

[0007] In the first aspect, the present application provides a soothing and anti-allergic composition, which adopts the following technical solution: A soothing and anti-allergic composition comprises agrimony extract, purslane extract, niacinamide, sodium shale oil sulfonate, rhodiola root extract and artemisia quercetin leaf extract; the mass ratio of the agrimony extract, purslane extract, niacinamide, sodium shale oil sulfonate, rhodiola root extract and artemisia quercetin leaf extract is (1-5): (1-10): (1-3): (0.1-1): (0.05-0.2): (0.1-5).

[0008] By employing the aforementioned technical solution, the present invention innovatively combines Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Sodium Shale Oil Sulfonate, Rhodiola Rosea Root Extract, and Artemisia Capillaris Leaf Extract in a specific ratio to create a highly effective, synergistic, soothing, and anti-allergic composition. This composition acts on sensitive skin in multiple ways: precisely blocking inflammatory signaling and reducing the release of pro-inflammatory factors; deeply repairing damaged skin barriers and enhancing skin resistance; efficiently scavenging free radicals and boosting antioxidant capacity; inhibiting the growth of harmful bacteria and improving the skin's microbiome, thereby comprehensively alleviating skin allergy symptoms and accelerating the skin's return to a healthy state.

[0009] Preferably, the mass ratio of the agrimony extract, purslane extract, niacinamide, shale oil sodium sulfonate, rhodiola rosea root extract and artemisia argyi leaf extract is (2-4): (3-8): (1.5-2.5): (0.3-0.8): (0.1-0.15): (2-4).

[0010] By adopting the above technical solution and limiting the weight ratio, a relatively good balance can be found between the cost of raw materials and the soothing effect, which can exert the most efficient soothing effect.

[0011] In a second aspect, the present application provides an application of a soothing and anti-allergic composition in the preparation of cosmetics.

[0012] Preferably, the cosmetic is in the form of an aqueous solution, lotion, cream, gel or facial mask.

[0013] By adopting the above technical solutions, you can choose cosmetics in various dosage forms such as aqueous solutions and emulsions to meet diverse skin care needs.

[0014] Preferably, the mass percentage of the soothing and anti-allergic composition in the cosmetic is 3.25-24.2%.

[0015] By adopting the above technical solution, the addition ratio of the composition in cosmetics is limited, and the anti-allergic effect of the soothing anti-allergic composition is more efficiently exerted.

[0016] In a third aspect, the present application provides a soothing and anti-allergic essence, which adopts the following technical solution: A soothing and anti-allergic essence comprises, by mass percentage, 8-10% of a moisturizer, 0.03-0.05% of a chelating agent, 0.2-0.5% of a thickener, 0.4-4% of a solubilizer, 1-5% of agrimony extract, 1-10% of purslane extract, 1-3% of niacinamide, 0.1-1% of sodium shale oil sulfonate, 0.05-0.2% of rhodiola rosea root extract, 0.1-5% of artemisia quercetin leaf extract, and the balance deionized water.

[0017] By adopting the above technical solutions, the soothing and anti-allergic essence is based on a variety of active extracts such as agrimony and purslane, which synergistically exert anti-inflammatory, antioxidant, antibacterial and barrier repair effects; it is combined with auxiliary ingredients such as moisturizers and chelating agents to ensure the stability of the formula, achieve efficient soothing and anti-allergic effects, and take into account moisturizing and penetration absorption.

[0018] Preferably, the moisturizing agent is at least one of glycerin, propylene glycol, butylene glycol and sorbitol.

[0019] By adopting the above technical solution, glycerin, propylene glycol, butylene glycol and sorbitol are selected as moisturizers. Their excellent moisture absorption and moisturizing properties can work synergistically with active ingredients such as agrimony and purslane. While soothing and anti-allergic, they can continuously replenish moisture to the skin, strengthen the skin's barrier function, enhance the essence's water-locking ability, and enhance the overall skin care effect of the product.

[0020] Preferably, the chelating agent is at least one of disodium EDTA, sodium ethylenediaminetetramethylenephosphonate, sodium citrate and tetrasodium glutamate diacetate; and the thickener is at least one of polyacrylate crosspolymer-6, carbomer, hydroxyethyl cellulose and xanthan gum.

[0021] By adopting the above technical solution, disodium EDTA, sodium ethylenediaminetetra(methylenephosphonate), sodium citrate and tetrasodium glutamate diacetate are preferably used as chelating agents, which can effectively complex metal ions, prevent their catalytic oxidation, and ensure the stability of active ingredients; polyacrylate cross-linked polymer-6, Cambo, hydroxyethyl cellulose and xanthan gum are preferably used as thickeners to accurately control the texture of the essence, so that it has both good ductility and adhesion, and help active ingredients such as agrimony to penetrate evenly, thereby enhancing the soothing and anti-allergic effects and user experience.

[0022] Preferably, the solubilizer is at least one of PEG-40 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-6 caprylic / capric triglyceride and polysorbate 80.

[0023] By adopting the above technical solution, PEG-40 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-6 caprylic / capric triglyceride and polysorbate 80 are preferably used as solubilizers, which can significantly improve the solubility and dispersibility of extracts such as agrimony and rhodiola rosea root, ensure the full integration of various ingredients, and enhance the stability of the formula; at the same time, it helps the active ingredients to better penetrate the skin, synergistically exert soothing and anti-allergic effects, and enhance the overall skin care efficacy of the essence.

[0024] In a fourth aspect, the present application provides a method for preparing a soothing and anti-allergic essence, which adopts the following technical solution: A method for preparing a soothing and anti-allergic essence comprises the following steps: S1: Heat shale oil sodium sulfonate and solubilizer at 35-40°C until transparent and set aside; S2: Add deionized water to the emulsifier, stir and heat to 80-85℃, add moisturizer, chelating agent and thickener and stir evenly, homogenize for 3-5 minutes, and keep warm and stir for 10-15 minutes; S3: Cool down to 45-50°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated and solubilized shale oil sodium sulfonate and solubilizer, and stir until uniform; S4: Cool down to 35-40℃, and after the physical and chemical indicators are tested to be qualified, filter out the material to obtain the soothing and anti-allergic essence.

[0025] By employing this technical solution, the preparation method utilizes segmented temperature control and step-by-step material addition to precisely ensure the activity of each ingredient. The sodium shale oil sulfonate is first solubilized by heating to ensure dispersion, and then water-soluble and heat-sensitive ingredients are added at different temperature ranges to prevent inactivation of active substances due to high temperatures or interference. The result is a soothing, anti-allergic serum with uniform composition and stable efficacy.

[0026] In summary, this application has the following beneficial effects: 1. The soothing and anti-allergic composition of the present invention innovatively combines six ingredients including Agrimony Root, which works synergistically through multiple pathways such as blocking inflammatory signals, repairing the skin barrier, and providing antioxidant and antibacterial effects to comprehensively relieve skin allergies. The specific weight ratio achieves a balance between cost and soothing effect, thereby improving efficacy and cost-effectiveness.

[0027] 2. The essence of the present invention is based on a soothing and anti-allergic composition, combined with auxiliary ingredients such as glycerin, which not only ensures efficient soothing and anti-allergic effects, but also takes into account moisturizing and penetration. Additives such as disodium EDTA stabilize the formula, and the segmented temperature-controlled preparation process ensures the activity of the ingredients, and the efficacy of the finished product is uniform and stable.

[0028] 3. The soothing and anti-allergic composition of the present invention is applicable to various dosage forms such as aqueous solutions and emulsions. A mass percentage of 3.25-24.2% can effectively play its role, meet consumers' diverse skin care needs, and broaden the scope of product application. DETAILED DESCRIPTION

[0029] The present application is further described in detail below with reference to the embodiments.

[0030] Unless otherwise specified, the components, raw materials or instruments used in the embodiments and comparative examples of the present invention are all commercially available raw materials or instruments, and the components and raw materials used in each parallel experiment are all of the same kind.

[0031] Among them, Agrimony Root Extract was purchased from J2KBIOCO., LTD., South Korea. Portulaca oleracea extract was purchased from Hyundai Bioland Co., Ltd., South Korea; Nicotinamide was purchased from Hangzhou Weibolai Biotechnology Co., Ltd.; Sodium shale oil sulfonate was purchased from ICHTHYOL-GESELLSCHAFT Cordes, Hermanni & Co. (GmbH & Co.) KG, Germany.

[0032] Rhodiola rosea root extract was purchased from Hyundai Biolande Co., Ltd., South Korea; Artemisia selengensis leaf extract was purchased from Hyundai Bioland Co., Ltd., South Korea; The remaining raw materials are of conventional commercial cosmetic grade.

[0033] The embodiments of the present application provide a soothing and anti-allergic composition, comprising the following components in parts by weight: 1-5 parts of agrimony extract, 1-10 parts of purslane extract, 1-3 parts of niacinamide, 0.1-1 parts of sodium shale oil sulfonate, 0.05-0.2 parts of Rhodiola rosea root extract, and 0.1-5 parts of Artemisia argyi leaf extract.

[0034] Agrimony grove extract is rich in active ingredients such as flavonoids and phenols. Flavonoids and phenols can reduce skin inflammation through multi-target effects: on the one hand, they inhibit the mRNA expression of inflammatory factors such as IL-1β, IL-6, COX-2, and TNF-α, blocking the transduction of inflammatory signals at the transcriptional level; on the other hand, they inhibit 5α-reductase activity to reduce sebum production and reduce the risk of follicular inflammation caused by oil accumulation. At the same time, its antibacterial properties can inhibit pathogenic bacteria such as Staphylococcus aureus, eliminate sensitive triggers, and comprehensively relieve skin discomfort caused by allergies.

[0035] Portulaca oleracea extract is rich in active ingredients such as alkaloids, flavonoids, polysaccharides, etc. Its alkaloids and terpenes can inhibit bacterial protein synthesis and effectively inhibit the growth of harmful skin bacteria such as Propionibacterium acnes; flavonoids can enhance the skin's antioxidant capacity by scavenging free radicals and reduce the damage of oxidative stress to skin cells; polysaccharides and organic acids can regulate the activity of immune cells and reduce inflammatory responses, synergizing from multiple dimensions of antibacterial, antioxidant and anti-inflammatory effects to achieve rapid relief of skin sensitivity symptoms.

[0036] Niacinamide plays a dual role in skin barrier repair and inflammation suppression. Regarding barrier repair, niacinamide can upregulate the expression of serine palmitoyltransferase, promoting the synthesis of intercellular lipids such as ceramide and sphingolipids, while stimulating protein production in the epidermis, strengthening the skin's "brick wall structure" and enhancing its ability to resist external stimuli. Regarding anti-inflammatory effects, it can inhibit the release of pro-inflammatory cytokines from tissue cells and significantly reduce the levels of LPS-induced inflammatory factors such as IL-6 and TNF-α, reducing overactivation of immune cells, thereby effectively alleviating skin inflammation and providing a stable repair environment for sensitive skin.

[0037] Sodium shale oil sulfonate specifically inhibits the formation of the chemotactic arachidonic acid metabolite LTB4, blocking the chemotactic aggregation of neutrophils to the inflammatory site, thereby alleviating the symptoms of redness and swelling from the source; at the same time, it can directly act on sebaceous gland cells, inhibit the activity of fatty acid synthase, reduce excessive oil secretion, avoid the inflammatory response caused by sebum accumulation, and quickly soothe and calm the skin. It is especially suitable for the regulation of inflammation in oily and sensitive skin.

[0038] Rhodiola rosea root extract is rich in flavonoids, salidroside, polysaccharides and other ingredients. Salidroside can regulate the balance of T cell subsets, inhibit excessive immune responses mediated by Th17 cells, and enhance the function of regulatory T cells to achieve immune homeostasis; flavonoids and polysaccharides can scavenge free radicals through antioxidant effects, reduce the oxidative-induced expression of inflammatory factors, stimulate fibroblast activity, promote collagen fiber synthesis, accelerate the repair of damaged skin barriers, improve skin sensitivity from the root, and enhance skin tolerance.

[0039] Artemisia argyi leaf extract contains volatile oils and flavonoids, which inhibit the activation of NF-κB by TNF-α, block the transcription of chemokines such as IL-8 and CCL20, and reduce the infiltration of immune cells into skin tissue; at the same time, it inhibits the release of β-hexosaminidase and histamine, directly alleviating the itching and redness symptoms caused by allergies; in addition, it can also inhibit the production of cytokines such as IL-4 and TNF-α, regulate Th2 immune responses, and synergize from multiple levels of signal transduction, mediator release, and immune regulation to effectively inhibit skin allergic reactions.

[0040] This invention innovatively combines Agrimony Root extract, Portulaca Oleracea extract, niacinamide, sodium shale oil sulfonate, Rhodiola rosea root extract, and Artemisia argyi leaf extract in a specific ratio to create a highly effective, synergistic, soothing, and anti-allergic composition. This composition acts on sensitive skin in multiple ways: precisely blocking inflammatory signaling and reducing the release of pro-inflammatory factors; deeply repairing damaged skin barriers and enhancing skin resistance; efficiently scavenging free radicals and boosting antioxidant capacity; inhibiting the growth of harmful bacteria and improving the skin's microbiome, thereby comprehensively alleviating skin allergy symptoms and accelerating the recovery of skin to a healthy state.

[0041] Among them, the flavonoids and phenolic compounds in Agrimony Root extract can significantly inhibit the expression of inflammatory factors such as IL-1β and TNF-α, weakening the inflammatory response at the source. At the same time, its antibacterial properties synergize with the antibacterial components of Portulaca Oleracea extract to jointly inhibit the growth of harmful bacteria on the skin surface and eliminate potential allergic reactions. The antioxidant components in Portulaca Oleracea extract form an antioxidant network with the flavonoids and polysaccharides in Rhodiola Rosea root extract, comprehensively scavenging free radicals and reducing the damage caused by oxidative stress to skin cells, creating favorable conditions for subsequent repair. Niacinamide, with its properties of promoting ceramide synthesis and strengthening the skin barrier, cooperates with the effects of Rhodiola Rosea root extract in stimulating collagen synthesis and enhancing cell vitality, achieving dual repair of lipids and structural proteins, and stabilizing the skin barrier function. At the same time, niacinamide's function of inhibiting the release of inflammatory factors synergizes with the mechanism of Artemisia Selengensis Leaf Extract in blocking the NF-κB signaling pathway and reducing immune cell infiltration, further enhancing anti-inflammatory capabilities. The properties of sodium shale oil sulfonate, which inhibits LTB4 formation and controls oil, complement the sebum-regulating properties of agrimony extract, jointly regulating skin oil balance and preventing inflammation caused by sebum accumulation. Its soothing and calming effects, combined with the cooling properties of lotus water, quickly relieve skin discomfort. Artemisia quercetin leaf extract, by inhibiting histamine release and modulating the immune response to alleviate allergic symptoms, synergizes with other ingredients at different levels to achieve systemic repair and soothing effects on sensitive skin. The synergistic effect of these ingredients significantly enhances the overall efficacy.

[0042] It should be noted that the present invention does not limit the preparation method of the soothing and anti-allergic composition, and those skilled in the art will know how to prepare it into a composition based on the ratio of the composition of the present invention.

[0043] Illustratively, the preparation method of the soothing anti-allergic composition is: uniformly mix Agrimony Root Extract, Portulaca Oleracea Extract, niacinamide, shale oil sodium sulfonate, Rhodiola Rosea Root Extract, and Artemisia Capillaris Leaf Extract to obtain the soothing composition.

[0044] Example 1 A soothing and anti-allergic composition comprises the following components in parts by weight: 1 part of agrimony extract, 1 part of purslane extract, 1 part of niacinamide, 0.1 part of sodium shale oil sulfonate, 0.05 part of rhodiola rosea root extract and 0.1 part of artemisia quercetin leaf extract.

[0045] Example 2 The difference between Example 2 and Example 1 is that the amounts of the raw materials used are different.

[0046] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract and 2 parts of artemisia quercetin leaf extract.

[0047] Example 3 The difference between Example 3 and Example 1 is that the amounts of the raw materials used are different.

[0048] A soothing and anti-allergic composition comprises the following components in parts by weight: 4 parts of agrimony extract, 8 parts of purslane extract, 2.5 parts of niacinamide, 0.8 parts of sodium shale oil sulfonate, 0.15 parts of rhodiola rosea root extract and 4 parts of artemisia quercetin leaf extract.

[0049] Example 4 The difference between Example 4 and Example 1 is that the amounts of the raw materials used are different.

[0050] A soothing and anti-allergic composition comprises the following components in parts by weight: 5 parts of agrimony extract, 10 parts of purslane extract, 3 parts of niacinamide, 1 part of sodium shale oil sulfonate, 0.2 parts of rhodiola rosea root extract and 5 parts of artemisia quercetin leaf extract.

[0051] In order to verify the efficacy of the soothing and anti-allergic composition of the present invention, the soothing and anti-allergic compositions of Comparative Examples 1-6 were prepared by replacing the same type of substances on the basis of Example 2.

[0052] Comparative Example 1 The difference between Comparative Example 1 and Example 2 is that Comparative Example 1 uses Hamamelis virginiana extract instead of Agrimony grosvenori extract.

[0053] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of witch hazel extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of shale oil sodium sulfonate, 0.1 parts of rhodiola rosea root extract and 2 parts of artemisia quercetin leaf extract.

[0054] Comparative Example 2 The difference between Comparative Example 2 and Example 2 is that Comparative Example 2 uses Calendula officinalis extract instead of Portulaca oleracea extract.

[0055] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of calendula extract, 1.5 parts of niacinamide, 0.3 parts of shale oil sodium sulfonate, 0.1 parts of rhodiola rosea root extract and 2 parts of artemisia quercetin leaf extract.

[0056] Comparative Example 3 The difference between Comparative Example 3 and Example 2 is that panthenol is used instead of niacinamide in Comparative Example 3.

[0057] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of panthenol, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract and 2 parts of artemisia quercetin leaf extract.

[0058] Comparative Example 4 The difference between Comparative Example 4 and Example 2 is that Comparative Example 4 uses fish oil (ammonium sulfate salt of shale oil) to replace shale oil sodium sulfonate.

[0059] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of fish oil, 0.1 parts of rhodiola rosea root extract and 2 parts of artemisia quercetin leaf extract.

[0060] Comparative Example 5 The difference between Comparative Example 5 and Example 2 is that Comparative Example 5 uses Centella asiatica extract instead of Rhodiola rosea root extract.

[0061] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of Centella asiatica extract and 2 parts of Artemisia quercetin leaf extract.

[0062] Comparative Example 6 The difference between Comparative Example 6 and Example 2 is that Comparative Example 6 uses Artemisia argyi leaf extract instead of Artemisia argyi leaf extract.

[0063] A soothing and anti-allergic composition comprises the following components in parts by weight: 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of shale oil sodium sulfonate, 0.1 parts of rhodiola rosea root extract and 2 parts of mugwort leaf extract.

[0064] Performance Testing The soothing and anti-allergic compositions of Examples 1-4 and Comparative Examples 1-6 were mixed with deionized water supplemented to 100 parts by weight to prepare test samples for testing.

[0065] 1. Security testing Refer to the human skin patch test in the 2022 edition of the "Safety Technical Specifications for Cosmetics" to test whether the samples in Verification Examples 1-4 will cause skin irritation or allergic reactions. The specific experimental steps are as follows: (1) 120 people aged 18-60 years old, all female, were divided into 4 groups, corresponding to the samples of Examples 1-4, respectively. All people had no history of severe skin diseases, allergies or immune diseases; (2) The selected area shall not exceed 50mm 2Qualified patch test equipment with a depth of approximately 1 mm was used. 0.02 mL of the sample from Examples 1-4 was placed into the patch test chamber. The control well served as a blank control (no substance was placed). The patch test chamber containing the sample was applied to the healthy skin on both sides of the spine of the subject's back using hypoallergenic tape. Gently press the patch evenly onto the skin with the palm of your hand for 24 hours. Skin reactions were observed 30 minutes after removal (after the indentation disappeared), 24 hours, and 48 hours after removal of the finished product. The results were recorded. The reaction results are shown in Table 3 below, and the specific criteria for the reaction results are shown in Table 4 below.

[0066] Table 1 Human skin patch test results Table 2 Specific standards for reaction results Reaction level Symptom description Level 0 No response Level 1 erythema Level 2 Erythema, papules Level 3 Erythema, papules, edema, blisters Level 4 Severe erythema, edema, and large blisters It can be seen from Table 1 and Table 2 that the soothing and anti-allergic composition of the present invention is mild and non-irritating and has wide applicability.

[0067] 2. Hyaluronidase inhibition test High-molecular-weight hyaluronic acid plays a crucial role in regulating skin repair and can significantly reduce inflammatory responses. However, hyaluronic acid degradation products contribute to skin inflammation. This degradation is dependent on the activity of hyaluronidase. Hyaluronidase also participates in tissue inflammation and is a participant in type I hypersensitivity reactions, contributing to mast cell degranulation during the third phase of allergic reactions. Therefore, inhibition of hyaluronidase activity can be used as an indicator of a sample's anti-inflammatory and anti-allergic responses.

[0068] According to the cosmetics GDQT-SOP-166 hyaluronidase inhibition rate test method.

[0069] Test reagents: (1) Prepare 0.26 mol / L calcium chloride solution.

[0070] (2) Prepare a hyaluronidase solution with a concentration of 1250 U / ml, wherein the solvent of the hyaluronidase solution is an acetate buffer solution with a pH of 5.6.

[0071] (3) The test samples prepared from the soothing and anti-allergic compositions of Examples 1-4 and Comparative Examples 1-6 were diluted to 3 times their volumes using a pH 5.6 acetate buffer solution. Three parallel samples were prepared for each sample, and the prepared solution was the sample solution.

[0072] (4) A sodium hyaluronate solution with a concentration of 0.5 mg / ml was prepared using an acetate buffer solution with a pH of 5.6.

[0073] (5) Prepare 0.45 mol / L sodium hydroxide solution.

[0074] (6) A 6% volume concentration of acetylacetone solution was prepared using 1.2 mol / L carbonic acid solution.

[0075] (7) Prepare a 0.04 g / mL p-dimethylaminobenzaldehyde solution using equal volumes of concentrated hydrochloric acid and ethanol.

[0076] Test method: 0.1 ml of calcium chloride solution was added to 0.5 ml of hyaluronidase solution, and the mixture was incubated at 37°C for 20 minutes. Then, 0.3 ml of sample solution was added. After further incubation at 37°C for 20 minutes, 0.5 ml of sodium hyaluronate solution was added. After further incubation at 37°C for 20 minutes, 0.1 ml of sodium hydroxide solution and acetylacetone solution were added. The mixture was heated in a boiling water bath for 15 minutes, cooled to room temperature, and p-dimethylaminobenzaldehyde solution was added. After standing for 20 minutes to develop color, the absorbance at 530 nm was measured, and the hyaluronidase inhibition rate was calculated. The results are shown in Table 3 below.

[0077] Calculation formula: Hyaluronidase inhibition rate (%) = [(X1-X2)-(X3-X4)] / (X1-X2)×100%; Wherein: X1 is the absorbance value when the sample solution is replaced by the acetate buffer solution; X2 is the absorbance value when the sample solution and the hyaluronidase solution are replaced by the acetate buffer solution; X3 is the absorbance value when the sample solution is added; X4 is the absorbance value when the hyaluronidase solution is replaced by the acetate buffer solution.

[0078] Table 3 Hyaluronidase inhibition test results sample Hyaluronidase inhibition rate / % Blank control 0.53 Example 1 64.84 Example 2 70.31 Example 3 72.54 Example 4 74.22 Comparative Example 1 60.31 Comparative Example 2 58.73 Comparative Example 3 55.38 Comparative Example 4 51.99 Comparative Example 5 63.71 Comparative Example 6 58.65 As can be seen from Table 3, the hyaluronidase inhibition rate of the soothing and anti-allergic compositions of Examples 1-4 is at least greater than 64%, and the compositions of the present invention have excellent soothing and anti-allergic effects.

[0079] By comparing the hyaluronidase inhibition rates of Example 2 and Comparative Examples 1-6, it can be seen that the Herba Agrimoniae Extract, Portulaca Oleracea Extract, niacinamide, shale oil sodium sulfonate, Rhodiola Rosea Root Extract, and Artemisia Capillaris Leaf Extract described in the present invention have significant synergistic effects in soothing. Replacing any one of the compositions of the present invention with other ingredients will result in a significant decrease in the soothing effect, which shows that the formula of the present invention is irreplaceable.

[0080] In order to further verify the soothing and anti-allergic effect of the soothing and anti-allergic composition of the present invention in practical cosmetic applications, the soothing and anti-allergic compositions of Examples 1-4 and Comparative Examples 1-6 were formulated into essences, corresponding to Application Examples 1-4 and Comparative Examples 1-6, respectively.

[0081] Application Example 1 A soothing and anti-allergic essence comprises the following components in parts by weight: 8 parts of moisturizing agent, 0.03 parts of chelating agent, 0.2 parts of thickener, 0.4 parts of solubilizing agent, 1 part of agrimony extract, 1 part of purslane extract, 1 part of niacinamide, 0.1 parts of sodium shale oil sulfonate, 0.05 parts of rhodiola rosea root extract, 0.1 parts of artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0082] Wherein, the moisturizing agent is propylene glycol, the chelating agent is sodium citrate, the thickening agent is carbomer, and the solubilizing agent is PEG-20 hydrogenated castor oil.

[0083] The preparation method of the soothing and anti-allergic essence is: S1: Place shale oil sodium sulfonate and solubilizer in a container, heat at 35°C to solubilize until the solution becomes transparent and set aside; S2: Add deionized water to the emulsifier, stir at 20 rpm and heat to 80°C, add the moisturizer, chelating agent and thickener and stir evenly at 20 rpm, homogenize at 15 Hz for 3-5 minutes, and stir at 20 rpm for 10 minutes; S3: Cool down to 45°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated shale oil sulfonate sodium and solubilizer, and stir at 20 rpm for 15 minutes until uniform; S4: Cool down to 35℃, and after the physical and chemical indicators are tested to be qualified, filter the material with a 200-mesh filter cloth to obtain the soothing and anti-allergic essence.

[0084] Application Example 2 A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract, 2 parts of artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0085] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0086] The preparation method of the soothing and anti-allergic essence is: S1: Place shale oil sodium sulfonate and solubilizer in a container, heat at 37°C until the solution becomes transparent and set aside; S2: Add deionized water to the emulsifier, stir at 23 rpm and heat to 83°C, add the moisturizer, chelating agent and thickener and stir evenly at 23 rpm, homogenize at 20 Hz for 4 minutes, and keep stirring at 23 rpm for 13 minutes; S3: Cool down to 48°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated shale oil sulfonate sodium and solubilizer, and stir at 23 rpm for 20 minutes until uniform; S4: Cool down to 37°C, and after the physical and chemical indicators are tested to be qualified, filter the material with a 250-mesh filter cloth to obtain the soothing and anti-allergic essence.

[0087] Application Example 3 A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 4 parts of agrimony extract, 8 parts of purslane extract, 2.5 parts of niacinamide, 0.8 parts of sodium shale oil sulfonate, 0.15 parts of rhodiola rosea root extract, 4 parts of artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0088] Wherein, the moisturizing agent is butylene glycol, the chelating agent is tetrasodium glutamate diacetate, the thickener is hydroxyethyl cellulose, and the solubilizing agent is PEG-6 caprylic / capric triglyceride.

[0089] The preparation method of the soothing and anti-allergic essence is: S1: Place shale oil sodium sulfonate and solubilizer in a container, heat at 37°C until the solution becomes transparent and set aside; S2: Add deionized water to the emulsifier, stir at 23 rpm and heat to 83°C, add the moisturizer, chelating agent and thickener and stir evenly at 23 rpm, homogenize at 20 Hz for 4 minutes, and keep stirring at 23 rpm for 13 minutes; S3: Cool down to 48°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated shale oil sulfonate sodium and solubilizer, and stir at 23 rpm for 20 minutes until uniform; S4: Cool down to 37°C, and after the physical and chemical indicators are tested to be qualified, filter the material with a 250-mesh filter cloth to obtain the soothing and anti-allergic essence.

[0090] Application Example 4 A soothing and anti-allergic essence comprises the following components in parts by weight: 10 parts of a moisturizer, 0.05 parts of a chelating agent, 0.5 parts of a thickener, 4 parts of a solubilizer, 5 parts of agrimony extract, 10 parts of purslane extract, 3 parts of niacinamide, 1 part of sodium shale oil sulfonate, 0.2 parts of rhodiola rosea root extract, 5 parts of artemisia argyi leaf extract, and deionized water to make up to 100 parts.

[0091] Wherein, the moisturizing agent is sorbitol, the chelating agent is sodium ethylenediaminetetramethylenephosphonate, the thickener is xanthan gum, and the solubilizing agent is polysorbate 80.

[0092] The preparation method of the soothing and anti-allergic essence is: S1: Place shale oil sodium sulfonate and solubilizer in a container, heat at 40°C to solubilize until the solution becomes transparent and set aside; S2: Add deionized water to the emulsifier, stir at 25 rpm and heat to 85°C, add the humectant, chelating agent and thickener and stir evenly at 25 rpm, homogenize at 25 Hz for 5 minutes, and keep stirring at 25 rpm for 15 minutes; S3: Cool down to 50°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated solubilized shale oil sodium sulfonate and solubilizer, and stir at 25 rpm for 30 minutes until uniform; S4: Cool down to 40℃, and after the physical and chemical indicators are tested to be qualified, filter the material through a 300-mesh filter cloth to obtain the soothing and anti-allergic essence.

[0093] Comparative Application Example 1 The difference between Application Example 1 and Application Example 2 is that Application Example 1 uses Hamamelis virginiana extract instead of Agrimony grosvenori extract.

[0094] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of a witch hazel extract, 3 parts of a purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of a rhodiola rosea root extract, 2 parts of an artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0095] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0096] Application Comparative Example 2 The difference between Application Comparative Example 2 and Application Example 2 is that Application Comparative Example 2 uses Calendula officinalis extract instead of Portulaca oleracea extract.

[0097] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of agrimony extract, 3 parts of calendula extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract, 2 parts of artemisia argyi leaf extract, and deionized water to make up to 100 parts.

[0098] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0099] Application Comparative Example 3 The difference between Application Comparative Example 3 and Application 2 is that Application Comparative Example 3 uses panthenol instead of niacinamide.

[0100] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of moisturizing agent, 0.04 parts of chelating agent, 0.3 parts of thickener, 2 parts of solubilizing agent, 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of panthenol, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract, 2 parts of artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0101] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0102] Comparative Application Example 4 The difference between Application Example 4 and Application Example 2 is that Application Example 4 uses fish oil (ammonium sulfate salt of shale oil) to replace shale oil sodium sulfonate.

[0103] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of fish oil, 0.1 parts of rhodiola rosea root extract, 2 parts of artemisia argyi leaf extract, and deionized water to make up to 100 parts.

[0104] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0105] Application Comparative Example 5 The difference between Application Example 5 and Application Example 2 is that Application Example 5 uses Centella asiatica extract to replace Rhodiola rosea root extract.

[0106] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of Centella asiatica extract, 2 parts of Artemisia quercetin leaf extract, and deionized water to make up to 100 parts.

[0107] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0108] Application Comparative Example 6 The difference between Comparative Example 6 and Application Example 2 is that in Application Example 6, Artemisia argyi leaf extract is used instead of Artemisia argyi leaf extract.

[0109] A soothing and anti-allergic essence comprises the following components in parts by weight: 9 parts of a moisturizer, 0.04 parts of a chelating agent, 0.3 parts of a thickener, 2 parts of a solubilizer, 2 parts of agrimony extract, 3 parts of purslane extract, 1.5 parts of niacinamide, 0.3 parts of sodium shale oil sulfonate, 0.1 parts of rhodiola rosea root extract, 2 parts of wormwood leaf extract, and deionized water to make up to 100 parts.

[0110] Wherein, the moisturizing agent is glycerin, the chelating agent is disodium EDTA, the thickener is polyacrylate cross-polymer-6, and the solubilizing agent is PEG-40 hydrogenated castor oil.

[0111] The preparation methods of the soothing and anti-allergic essences of Comparative Examples 1-6 are the same as those of Application Example 2.

[0112] 3. Skin red zone recovery test Fifty female volunteers with facial redness were selected and divided equally into 10 groups. Each group received the soothing and anti-allergic essences from Examples 1-4 and Comparative Examples 1-6, respectively. After cleansing their faces, the subjects evenly applied the corresponding soothing and anti-allergic essences to their faces and gently massaged until absorbed. This was done once in the morning and evening for 28 consecutive days. The reduction in facial redness was analyzed using a VISIA-CR facial image analyzer. The results are shown in Table 4 below.

[0113] Table 4 Skin red zone recovery test results As can be seen from Table 4, the soothing essences in Application Examples 1-4 have a reduction rate of A value of the skin red zone of more than 10%, and a reduction rate of the skin red zone area ratio of more than 20%. The soothing and anti-allergic essences prepared from the composition of the present invention have excellent soothing and anti-allergic effects.

[0114] Comparing the test results of the soothing and anti-allergic essences of Application Example 2 and Comparative Examples 1-6, it can be seen that the skin red zone A value reduction rate of the soothing essence of Application Example 2 is 12.72%, and the skin red zone area ratio reduction rate is 22.15%. Both data are better than the soothing and anti-allergic essences of Comparative Examples 1-6. This shows that the Agrimony extract, Portulaca oleracea extract, niacinamide, shale oil sodium sulfonate, Rhodiola rosea root extract, and Artemisia argyi leaf extract described in the present invention can still significantly synergistically improve the soothing and anti-allergic effects in the prepared soothing and anti-allergic essence. The soothing and anti-allergic composition of the present invention can also be prepared into other forms of cosmetics, including lotions, emulsions, creams, gels, or facial masks.

[0115] In one embodiment, the cosmetic further comprises excipients acceptable in the cosmetics field.

[0116] The auxiliary material is at least one of water, moisturizer, emulsifier, humectant, antioxidant, penetration enhancer, essence and pigment.

[0117] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A soothing and anti-allergic composition, characterized in that: The invention comprises agrimony extract, purslane extract, niacinamide, sodium shale oil sulfonate, rhodiola root extract and artemisia quercetin leaf extract; the mass ratio of the agrimony extract, purslane extract, niacinamide, sodium shale oil sulfonate, rhodiola root extract and artemisia quercetin leaf extract is (1-5): (1-10): (1-3): (0.1-1): (0.05-0.2): (0.1-5).

2. A soothing and anti-allergic composition according to claim 1, characterized in that: The mass ratio of the agrimony extract, purslane extract, niacinamide, shale oil sodium sulfonate, rhodiola rosea root extract and artemisia argyi leaf extract is (2-4): (3-8): (1.5-2.5): (0.3-0.8): (0.1-0.15): (2-4).

3. Use of the soothing and anti-allergic composition according to any one of claims 1 to 2 in the preparation of cosmetics.

4. The use according to claim 3, characterized in that: The dosage form of the cosmetic is water solution, emulsion, cream, gel or facial mask.

5. The use according to claim 4, characterized in that: The mass percentage of the soothing and anti-allergic composition in the cosmetic is 3.25-24.2%.

6. A soothing and anti-allergic essence, characterized in that: The invention comprises, by mass percentage, 8-10% of a moisturizer, 0.03-0.05% of a chelating agent, 0.2-0.5% of a thickener, 0.4-4% of a solubilizer, 1-5% of agrimony extract, 1-10% of purslane extract, 1-3% of niacinamide, 0.1-1% of sodium shale oil sulfonate, 0.05-0.2% of rhodiola rosea root extract, 0.1-5% of artemisia quercetin leaf extract and the balance deionized water.

7. The soothing and anti-allergic essence according to claim 6, characterized in that: The moisturizing agent is at least one of glycerin, propylene glycol, butylene glycol and sorbitol.

8. The soothing and anti-allergic essence according to claim 6, characterized in that: The chelating agent is at least one of disodium EDTA, sodium ethylenediaminetetramethylenephosphonate, sodium citrate and tetrasodium glutamate diacetate; and the thickener is at least one of polyacrylate cross-linked polymer-6, carbomer, hydroxyethyl cellulose and xanthan gum.

9. The soothing and anti-allergic essence according to claim 6, characterized in that: The solubilizer is at least one of PEG-40 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-6 caprylic / capric triglyceride and polysorbate 80.

10. The method for preparing the soothing and anti-allergic essence according to any one of claims 6 to 9, characterized in that: The steps include: S1: Heat shale oil sodium sulfonate and solubilizer at 35-40°C until transparent and set aside; S2: Add deionized water to the emulsifying pot, stir and heat to 80-85℃, add moisturizer, chelating agent and thickener and stir evenly, homogenize for 3-5 minutes, keep warm and stir for 10-15 minutes; S3: Cool down to 45-50°C, add Agrimony Root Extract, Portulaca Oleracea Extract, Niacinamide, Rhodiola Rosea Root Extract, Artemisia Capillaris Leaf Extract, and pre-heated and solubilized shale oil sodium sulfonate and solubilizer, and stir until uniform; S4: Cool down to 35-40℃, and after the physical and chemical indicators are tested to be qualified, filter out the material to obtain the soothing and anti-allergic essence.

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