Anti-wrinkle composition based on microemulsion synergistic interaction and application

Abstract

The invention discloses an anti-wrinkle composition based on micro-emulsion synergistic interaction and application, and belongs to the field of cosmetics, the anti-wrinkle composition comprises the following components by mass: 0.5-3 parts of a water-soluble chrysanthemum extract; 0.5-2 parts of an oil-soluble saussurea involucrata extract; 0.1 to 1 part of dipalmitoyl hydroxyproline; and 1 to 2 parts of tribehenyl PEG-20 esters. By combining a microemulsion technology, anti-wrinkle active matters can be dispersed into small particles which are more easily absorbed by skin, the anti-wrinkle active matters can be promoted to better exert effects, the product is made into a microemulsion particle size by pertinently designing and matching a formula system, the active components can be more easily absorbed by skin, and the anti-wrinkle effect can be improved. The effect of adding low amount of functional active matter to high amount of functional active matter is achieved, the production cost of manufacturers is reduced, and the anti-wrinkle effect is achieved from multiple dimensions.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle composition based on microemulsification synergistic enhancement and its application. Background Art

[0002] With the improvement of living standards and the pursuit of beauty, the demand for anti-aging and anti-wrinkle skincare products is growing. Consumers not only expect skincare products to effectively improve wrinkles and other aging skin problems, but also want them to be safe, gentle, and easily absorbed. Microemulsification technology, which can significantly improve the stability and penetration of skincare products, has become an important way to enhance the performance of anti-wrinkle compositions.

[0003] The selection of anti-wrinkle ingredients is crucial in developing anti-wrinkle compositions. Currently known anti-wrinkle ingredients include vitamin C, retinol, phospholipids, peptides, and botanical active ingredients. These ingredients have demonstrated remarkable effectiveness in promoting collagen synthesis, enhancing skin elasticity, and inhibiting wrinkle formation. However, the anti-wrinkle effects of the same ingredient vary depending on the dosage, requiring a high dosage of a single active ingredient to be effective. Consequently, brands and manufacturers often overdo the dosage of these ingredients to achieve satisfactory results, significantly increasing product development costs.

[0004] Traditional anti-wrinkle products rely on high concentrations of active ingredients (e.g., 0.1%-1% for retinol), which can easily cause skin irritation and are costly. Conventional emulsifiers have large particle sizes (200-500nm), resulting in low transdermal absorption rates of active ingredients (<20%), necessitating high dosages to compensate for this inefficiency.

[0005] While microemulsification technology can improve absorption, it also suffers from poor stability (easily oxidized by Ostwald ripening) and the need for high surfactant concentrations (>15%), which can cause skin sensitivity. To address the issue of excessive accumulation of active ingredients, this application provides a composition and preparation method that utilizes microemulsification technology optimized through a high-pressure homogenization process and a combination of specific active ingredients to achieve high anti-wrinkle efficacy at low dosages. Summary of the Invention

[0006] The purpose of the present invention is to provide an anti-wrinkle composition based on microemulsification synergistic enhancement and its application, so as to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A microemulsification-based synergistic anti-wrinkle composition comprising the following components in parts by weight:

[0009] 0.5-3 parts of water-soluble Spinach extract;

[0010] 0.5-2 parts of oil-soluble Spinach extract;

[0011] Dipalmitoylhydroxyproline 0.1-1 part;

[0012] 1-2 parts of Tribehenin PEG-20 Esters.

[0013] Acmella oleracea extract, rich in alkanamides, is known as the botulinum toxin of the plant world, offering immediate wrinkle-reducing effects. Acmella oleracea extract achieves its positive effects on the skin by stimulating the natural vitality of skin fibroblasts and their contractility, thereby enhancing the interaction between cells and collagen fibers. This interaction reduces wrinkles, smoothes the skin, and restores firmness and smoothness. Acmella oleracea extract acts on nerve cells, where electrical signals from nerve impulses are transmitted. By inhibiting sodium ion channels, it prevents nerve impulses from transmitting, thereby rapidly relaxing muscles and smoothing expression lines. Dipalmitoylhydroxyproline is a chemical that plays a key role in promoting the interaction between connective tissue cells and the extracellular matrix (ECM). Specifically, it stimulates the regeneration of collagen fibers into a denser structure, providing stronger support in the interstitial matrix and strengthening the skin. As skin ages, the production of connective tissue cells and elastin fibers decreases, and the activation of specific enzymes leads to increased breakage of these fibers. The mechanism of action of dipalmitoyl hydroxyproline may help counteract this aging process by strengthening the skin's structure and support, thereby improving its appearance and texture. Tribehenin PEG-20 esters are used in cosmetics not only as emollients but also as emulsifiers. The primary function of emulsifiers in cosmetics is to facilitate the mixing of the oil and water phases, forming a stable emulsion and preventing product separation or demulsification during use. For tribehenin PEG-20 esters, its emulsifying effect may be manifested in its ability to form fine oil droplets that are evenly dispersed in the water phase, creating a stable emulsion. This emulsion not only enhances the appearance and texture of products but also ensures effective delivery and absorption of active ingredients. Furthermore, tribehenin PEG-20 esters exhibits broad compatibility with a variety of oils, pH adjusters, and specialty active ingredients, creating an elegant balance between a thick, creamy appearance and a readily dispersible feel. This property makes it an ideal choice for formulating microemulsified skincare products. It's important to note that while Tribehenin PEG-20 esters are widely used in cosmetics, different product formulations and usage methods may affect their emulsification effectiveness. Therefore, in specific applications, it's important to rationally select and use emulsifiers based on product requirements and formulation design.

[0014] Preferably, the following components are also included in parts by mass:

[0015] 5-20 parts of polyol;

[0016] 2-15 parts of moisturizer;

[0017] 5-20 parts of emollient;

[0018] 0.1-1 parts of preservatives;

[0019] 1-10 parts of skin conditioning agent;

[0020] 1-5 parts of emulsifier;

[0021] 0.2-1 part antioxidant;

[0022] Thickener 0.1-2 parts;

[0023] 0.1-1 part of pH regulator;

[0024] Chelating agent 0.01-1 part.

[0025] Preferably, the polyol is selected from any one or a combination of at least two of glycerol, butylene glycol, 1,3-propylene glycol, dipropylene glycol, and methyl propylene glycol.

[0026] Preferably, the moisturizing agent is glycerin, butylene glycol, glyceryl polyether-26, panthenol, 1,2-hexanediol, cholesteryl hydroxystearate, hydrolyzed sodium hyaluronate, etc.

[0027] Preferably, the emollient is selected from the group consisting of: isononyl isononanoate, hydrogenated polyisobutene, pentaerythritol tetra(ethylhexanoate), jojoba seed oil, squalane, caprylic / capric triglyceride, shea butter, ethylhexylglycerin, or any one or a combination of at least two thereof.

[0028] Preferably, the thickener is selected from: xanthan gum, carbomer, hydroxyethyl cellulose, ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer 6, acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer, any one or a combination of at least two.

[0029] Preferably, the skin conditioning agent is selected from: any one or a combination of at least two of niacinamide, xylitol glucoside, anhydroxylitol, xylitol, Italian helichrysum extract, soybean oil, carrot root extract, β-carotene, and bisabolol.

[0030] Preferably, the preservative is selected from the group consisting of: phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, caprylyl glycol, and ethylhexylglycerin;

[0031] The pH regulator is selected from any one of citric acid, tromethamine, and arginine, or a combination of at least two thereof;

[0032] The antioxidant is selected from: any one of p-hydroxyacetophenone and tocopheryl acetate or a combination of at least two thereof.

[0033] Preferably, the composition is treated by a high-pressure homogenization process, wherein the high-pressure pressure is 120-150 MPa, the process is repeated 5 times, and the temperature is 43-47° C. The average particle size of the composition is 50-100 nm, the PDI is less than 0.2, and the Zeta potential is ≤-30 mV.

[0034] An application of an anti-wrinkle composition based on microemulsification synergistic enhancement, wherein the anti-wrinkle product is an emulsion, cream, etc.

[0035] Technical effects and advantages of the present invention:

[0036] The present invention combines microemulsion technology to disperse anti-wrinkle active ingredients into tiny particles that are more easily absorbed by the skin, promoting the anti-wrinkle active ingredients to better exert their efficacy. Through targeted formulation system design and matching, the product is made into a microemulsified particle size, which is more conducive to the active ingredients being absorbed by the skin, achieving the efficacy of high-dosage addition with low-dosage active ingredients, reducing manufacturers' production costs, and achieving anti-wrinkle effects from multiple dimensions. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 Comparison of wrinkles of volunteer 1 before use (left picture) and 28 days after use (right picture) after using the emulsion of Example 1. DETAILED DESCRIPTION

[0038] The following is a combination of the embodiments of the present invention Figure 1 , the technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. The specific embodiments described here are only used to explain the present invention and are not used to limit the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0039] Microemulsification technology is a technique that disperses oil droplets into tiny particles, making the emulsion more stable and easier to absorb. In the development of anti-wrinkle compositions, microemulsification technology has the following advantages:

[0040] Improve stability: Microemulsification technology can significantly improve the stability of the composition and prevent component separation and failure.

[0041] Enhanced penetration: The small size of microemulsified particles makes it easier for skin care products to penetrate the skin barrier and reach deep tissues to take effect.

[0042] Improved efficacy: Due to the enhanced penetration, anti-wrinkle ingredients can be more effectively absorbed and utilized by the skin, thereby improving the anti-wrinkle effect.

[0043] The present invention discloses an anti-wrinkle composition based on microemulsification synergistic enhancement, comprising the following components in parts by weight:

[0044] 0.5-3 parts water-soluble Acmella oleracea extract; 0.5-2 parts oil-soluble Acmella oleracea extract; 0.1-1 parts dipalmitoyl hydroxyproline; 1-2 parts triphenin PEG-20 esters; 5-20 parts polyol; 2-15 parts humectant; 5-20 parts emollient; 0.1-1 part preservative; 1-10 parts skin conditioner; 1-5 parts emulsifier; 0.2-1 part antioxidant; 0.1-2 parts thickener; 0.1-1 part pH adjuster; 0.01-1 part chelating agent. The weight ratio of water-soluble Acmella oleracea extract to oil-soluble Acmella oleracea extract is 1-1.5:1.

[0045] The polyol is selected from any one or a combination of at least two of glycerol, butylene glycol, 1,3-propylene glycol, dipropylene glycol, and methylpropylene glycol.

[0046] Moisturizing agents include glycerin, butylene glycol, glyceryl polyether-26, panthenol, 1,2-hexanediol, cholesterol hydroxystearate, hydrolyzed sodium hyaluronate, etc.

[0047] The emollient is selected from the group consisting of: isononyl isononanoate, hydrogenated polyisobutene, pentaerythritol tetra(ethylhexanoate), jojoba seed oil, squalane, caprylic / capric triglyceride, shea butter, ethylhexylglycerin, or any one or a combination of at least two.

[0048] The thickener is selected from the group consisting of: xanthan gum, carbomer, hydroxyethyl cellulose, ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer 6, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, or any one or a combination of at least two thereof.

[0049] The skin conditioning agent is selected from the group consisting of: niacinamide, xylitol glucoside, anhydroxylitol, xylitol, Italian helichrysum extract, soybean oil, carrot root extract, β-carotene, and bisabolol, or any one or a combination of at least two thereof.

[0050] The preservative is selected from the group consisting of: phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, caprylyl glycol, and ethylhexylglycerin.

[0051] The pH regulator is selected from: any one of citric acid, tromethamine, and arginine, or a combination of at least two thereof, and the pH is between 5 and 7.

[0052] The antioxidant is selected from: any one of p-hydroxyacetophenone and tocopheryl acetate or a combination of at least two thereof.

[0053] The composition is treated by a high-pressure homogenization process with a high pressure of 120-150 MPa, 5 cycles, and a temperature of 43-47° C. The composition has an average particle size of 50-100 nm, a PDI of less than 0.2, and a Zeta potential of less than or equal to -30 mV.

[0054] Innovative emulsifier system: Tribehenin PEG-20 esters are combined with polyols (glycerin, butylene glycol) to reduce the total surfactant content to less than 5%, while achieving nano-particle size (50-100nm) and six-month stability (no stratification after centrifugation at 3000rpm).

[0055] Active ingredient synergy: Through the specific ratio (1-1.5:1) of water-soluble / oil-soluble Acmella oleracea extract and dipalmitoyl hydroxyproline, a "membrane-core" composite structure is formed at the microemulsion interface, increasing collagen stimulation efficiency by 3 times (in vitro fibroblast test)

[0056] An application of an anti-wrinkle composition based on microemulsification synergistic enhancement, wherein the anti-wrinkle product is an emulsion, a cream, etc.

[0057] Example 1 is an anti-wrinkle composition based on microemulsification synergistic enhancement, and the types of raw materials and the composition by weight are as follows:

[0058] Phase A: deionized water TO 100;

[0059] Disodium EDTA 0.05%;

[0060] Glycerol 5.00%;

[0061] Butanediol 3.00%;

[0062] Xanthan gum 0.05%;

[0063] Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.20%;

[0064] Hydrolyzed sodium hyaluronate 0.05%;

[0065] Trehalose 2.00%;

[0066] Ammonium acryloyldimethyltaurate / VP copolymer 0.30%;

[0067] Glycereth-26 2.00%;

[0068] Niacinamide 2.00%;

[0069] Panthenol 0.50%;

[0070] Phase B: p-hydroxyacetophenone 0.5%;

[0071] Phase C: Tribehenin PEG-20 esters 1.50%;

[0072] Polyglyceryl-3 Methyl Glucose Distearate 0.50%;

[0073] Cetearyl alcohol 0.30%;

[0074] Isononyl isononanoate 2.00%;

[0075] Hydrogenated polyisobutene, tocopherol (vitamin E) 2.00%;

[0076] Squalane 0.50%;

[0077] Caprylic / capric triglyceride 0.50%;

[0078] Pentaerythritol tetra(ethylhexanoate) 1.00%;

[0079] Jojoba (SIMMONDSIA CHINENSIS) seed oil 1.00%;

[0080] Avocado tree (BUTYROSPERMU M PARKII) fruit fat 0.50%;

[0081] Cholesteryl hydroxystearate 0.20%;

[0082] Dipalmitoylhydroxyproline 1.0%;

[0083] Caprylic / capric triglyceride, ACMELLA OLERACEA extract 0.50%;

[0084] Tocopheryl acetate 0.20%;

[0085] Phase D: deionized water 1.80%;

[0086] Arginine 0.20%;

[0087] Phase E: xylitol glucoside, anhydroxylitol, water, xylitol 2.00%;

[0088] Glycerin, water, Helichrysum italiensis (Helichrysum talicum) extract 0.50%;

[0089] 1,3-Propanediol, Water, ACMELLAOLERACEA Extract 0.50%;

[0090] Bisabolol 0.10%;

[0091] 1,2-Hexanediol 0.40%;

[0092] Ethylhexylglycerin, tocopherol (vitamin E) 0.05%;

[0093] Glycine Soja (Soybean) Oil, Carrot (Daucus Carota Sativa) Root Extract, Beta-Carotene 0.15%;

[0094] The preparation method is as follows:

[0095] Add the raw materials of phase A into the water phase pot according to the weight percentage of the raw materials, stir and heat to 80-85℃, and set aside.

[0096] Add the raw materials of phase C into the oil phase pot according to the weight percentage of the raw materials, stir and heat to 80-85℃, and set aside.

[0097] Add phase B to the mixing bowl before homogenizing, homogenize for 3 minutes, and stir to dissolve evenly;

[0098] Pump phase A material in the water phase pot into the emulsification pot, and pump phase C material in the oil phase pot into the emulsification pot, stir and homogenize for 8 minutes, keep warm and stir for 15 minutes, and continue stirring to cool down.

[0099] When the temperature drops to 65±2℃, add the pre-dissolved phase D and homogenize for 5 minutes and stir evenly.

[0100] When the temperature drops to 45±2℃, add phase E and homogenize for 5 minutes. Stir evenly.

[0101] Cool down to 35±2℃, check the physical and chemical indicators, and filter out the material after passing the test (300 mesh filter cloth).

[0102] Example 2

[0103] The difference from Example 1 is that Example 2 does not contain tribehenin PEG-20 esters, but contains glyceryl stearate and PEG-100 stearate, with a mass ratio of 1.50%.

[0104] Comparative Example 1

[0105] The difference from Example 1 is that: the water-soluble ACMELLA OLERACEA extract is not included, and the added amount of the oil-soluble ACMELLA OLERACEA extract is 1 part.

[0106] Comparative Example 2

[0107] The difference from Example 1 is that the oil-soluble ACMELLA OLERACEA extract is not included, and the added amount of the water-soluble ACMELLA OLERACEA extract is 1 part.

[0108] Comparative Example 3

[0109] The difference from Example 1 is that the mass fraction of type D is as follows: hydrolyzed corn starch 1%; Saururus chinensis extract 0%; carrot root extract 0.05%; water-soluble hesperidin 0.005%.

[0110] Comparative Example 3

[0111] The difference from Example 1 is that the added amount of the water-soluble ACMELLA OLERACEA extract and the oil-soluble ACMELLA OLERACEA extract is 1 part, which is twice that of Example 1.

[0112] Blank example 1

[0113] The difference from Example 1 is that: it does not contain dipalmitoyl hydroxyproline, water-soluble ACMELLA OLERACEA extract, and oil-soluble ACMELLA OLERACEA extract.

[0114] The specific compositions of various compounds in different examples are shown in Table 1:

[0115]

[0116]

[0117]

[0118]

[0119] Table 1

[0120] Efficacy testing

[0121] Test 1: Efficacy test

[0122] Test substances: the emulsions of Example 1, Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3, and Blank Example 1.

[0123] Test method: Refer to "Standard for improving crow's feet: T / SHRH-018-2021 Clinical evaluation method for the efficacy of cosmetics in improving wrinkles at the canthus", "Standard for improving the firmness of skin around the eyes: T / ZHCA 005-2019 Test method for the impact of cosmetics on skin elasticity", "Cosmetic efficacy evaluation (ⅩⅢ) - Consumer use test_Liu Weiyi", "Application of sensory evaluation and instrument testing in cosmetics evaluation by Xue Zhen".

[0124] 180 subjects who met the inclusion criteria were selected to participate in the trial, and all subjects were randomly divided into 6 groups, with 30 people in each group. The subjects in each group were respectively tested with Example 1, Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3, and Blank Example 1.

[0125] The inclusion criteria for the subjects are: Chinese men or women aged 30-60 years old who are in good health; with obvious wrinkles at the corners of the eyes (crow's feet); able to cooperate well with the experimenters; able to read and understand the experimental process and sign the informed consent form in writing; and able to commit to completing the specified content according to the requirements of the test plan.

[0126] Exclusion criteria: those who have tried antihistamines in the past week or used immunosuppressants in the past month; those who have applied any anti-inflammatory drugs to the test site in the past two months; subjects with clinically unresolved inflammatory skin diseases; patients with insulin-dependent diabetes; patients with asthma or other chronic respiratory diseases being treated; those who have received anti-cancer chemotherapy in the past 6 months; patients with immunodeficiency or autoimmune diseases; breastfeeding or pregnant women; those who have undergone bilateral mastectomy and bilateral axillary lymph node resection; those whose skin test sites have scars, pigmentation, atrophy, port-wine stains, uneven skin color, folliculitis or other blemishes that affect the judgment of the test results; those participating in other clinical trial researchers; those with highly sensitive constitutions; non-voluntary participants or those who cannot complete the required content according to the test requirements.

[0127] Termination and exit criteria: Those who fail to apply the test sample according to the test requirements or fail to make follow-up records as required during the trial; those who suffer from serious illness or have serious adverse reactions during use.

[0128] The subjects cleansed their faces with a cleanser and dried their skin with a dry tissue. They then sat in a laboratory at a temperature of 21±1°C and 50±10RH for 30 minutes. A doctor then assessed the appearance of wrinkles and wrinkles at the corners of their eyes, took photos, and performed instrumental tests on their skin moisture content and skin barrier function. After completing the tests, the subjects were given instructions for use and, after listening to the instructions, were given the test products. After cleansing their faces morning and evening, the subjects applied the corresponding test samples as instructed for each group for 28 consecutive days. Follow-up visits were conducted every 14 days to collect data and collect samples, providing the subjects' skin data after use.

[0129] Based on the skin data of each subject before and after use, the increase and decrease ratios between before use, 14 days of use, and 28 days of use were calculated. The test results are shown in Tables 2-5. Table 2 shows the VISIA eye wrinkle test results; Table 3 shows the skin firmness F4 test results; and Table 4 shows the skin elasticity R2 results.

[0130] Table 5 shows the evaluation of the test products after 28 days of use by the subjects.

[0131]

[0132] Table 3

[0133]

[0134] Table 4

[0135]

[0136] Table 5

[0137] Group Overall experience Anti-wrinkle effect Firming effect Example 1 100％ 100％ 100％ Comparative Example 1 100％ 93.33％ 90％ Comparative Example 2 100％ 90％ 90％ Example 2 93.33％ 96.67％ 96.67％ Comparative Example 3 100％ 100％ 100％ Blank example 66.67％ 63.33％ 63.33％

[0138] Table 6

[0139] Experimental results

[0140] As shown in Table 2, Example 1 contains 1.5 parts of tribehenin PEG-20 esters, without glyceryl stearate or PEG-100 stearate. Example 2 contains 1.5 parts of glyceryl stearate and PEG-100 stearate, without tribehenin PEG-20 esters; all other ingredients remain the same. Analysis of the data in Tables 3-6 shows that Example 1 exhibits significantly better efficacy than Example 2, demonstrating that the anti-wrinkle composition with a microemulsified particle size exhibits more pronounced anti-wrinkle efficacy.

[0141] As shown in Table 2, the difference between Example 1 and Comparative Examples 1, 2, and 3 is that Comparative Example 1 does not contain water-soluble ACMELLA OLERACEA extract, and the amount of oil-soluble ACMELLA OLERACEA extract added is 1 part; Comparative Example 1 does not contain oil-soluble ACMELLA OLERACEA extract, and the amount of water-soluble ACMELLA OLERACEA extract added is 1 part; Comparative Example 3 contains oil-soluble ACMELLA OLERACEA extract and water-soluble ACMELLA OLERACEA extract added in 1 part each. According to the data analysis of Tables 3-6, the efficacy of Example 1 is significantly better than that of Comparative Examples 1 and 2, and slightly inferior to that of Comparative Example 3. The difference in efficacy is not very large, indicating that the anti-wrinkle and firming effects of the water-soluble ACMELLA OLERACEA extract and the oil-soluble ACMELLA OLERACEA extract are better under the synergistic effect. According to the relationship between raw material cost and efficacy, Example 1 selected the addition of 0.5 parts of oil-soluble ACMELLA OLERACEA extract and water-soluble ACMELLA OLERACEA extract. Figure 1 According to the comparison of the wrinkles at the corners of the eyes of two volunteers before and 28 days after using the emulsion of Example 1, it can be seen that the wrinkles at the corners of the eyes of Example 1 are significantly reduced, and it has the effect of reducing fine lines and anti-wrinkle.

[0142] Overall, the water-soluble ACMELLA OLERACEA extract can inhibit sodium ion channels, instantly soothe expression lines, and directional arrange in the interface membrane, promoting the penetration of dipalmitoyl hydroxyproline into the dermis; the oil-soluble ACMELLA OLERACEA extract can stimulate fibroblast activity and, as the oil phase core, form a liquid crystal structure with squalane, prolonging the sustained-release time of the active ingredient (in vitro release experiment T50 = 8h); dipalmitoyl hydroxyproline can promote collagen fiber remodeling and target the extracellular matrix (ECM) through the "core material" positioning of the microemulsion particles.

[0143] Finally, it should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An anti-wrinkle composition based on microemulsification synergistic enhancement, characterized by: Contains the following components by mass: 0.5-3 parts of water-soluble Spinach extract; 0.5-2 parts of oil-soluble Spinach extract; Dipalmitoylhydroxyproline 0.1-1 part; 1-2 parts of Tribehenin PEG-20 Esters.

2. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 1, characterized in that: The following components are also included in parts by weight: 5-20 parts of polyol; 2-15 parts of moisturizer; 5-20 parts of emollient; 0.1-1 parts of preservatives; 1-10 parts of skin conditioning agent; 1-5 parts of emulsifier; 0.2-1 part antioxidant; Thickener 0.1-2 parts; 0.1-1 part of pH regulator; Chelating agent 0.01-1 part.

3. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The polyol is selected from any one or a combination of at least two of glycerol, butylene glycol, 1,3-propylene glycol, dipropylene glycol, and methyl propylene glycol.

4. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The moisturizing agents include glycerin, butylene glycol, glyceryl polyether-26, panthenol, 1,2-hexanediol, cholesterol hydroxystearate, hydrolyzed sodium hyaluronate, and the like.

5. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The emollient is selected from the group consisting of: isononyl isononanoate, hydrogenated polyisobutene, pentaerythritol tetra(ethylhexanoate), jojoba seed oil, squalane, caprylic / capric triglyceride, shea butter, and ethylhexylglycerin, or any one or a combination of at least two thereof.

6. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The thickener is selected from the group consisting of: xanthan gum, carbomer, hydroxyethyl cellulose, ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer 6, acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer, or any one or a combination of at least two thereof.

7. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The skin conditioning agent is selected from: any one or a combination of at least two of niacinamide, xylitol glucoside, anhydroxylitol, xylitol, Italian helichrysum extract, soybean oil, carrot root extract, β-carotene, and bisabolol.

8. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 2, characterized in that: The preservative is selected from the group consisting of two or three of phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, 1,2-pentanediol, caprylyl glycol, and ethylhexylglycerin; The pH regulator is selected from any one of citric acid, tromethamine, and arginine, or a combination of at least two thereof; The antioxidant is selected from: any one of p-hydroxyacetophenone and tocopheryl acetate or a combination of at least two thereof.

9. The anti-wrinkle composition based on microemulsification synergistic enhancement according to claim 1, characterized in that: The composition is treated by a high-pressure homogenization process, wherein the high-pressure pressure is 120-150 MPa, the process is repeated 5 times, and the temperature is 43-47° C. The composition has an average particle size of 50-100 nm, a PDI of less than 0.2, and a Zeta potential of less than or equal to -30 mV.

10. The use of the microemulsification-based synergistic anti-wrinkle composition according to any one of claims 1 to 9, characterized in that: The anti-wrinkle product is lotion, cream, etc.

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