Medicinal and edible composition for improving eyesight and preparation method thereof
Through medicinal and food homologous compositions and lutein ester microcapsules technology, the problem of poor visual improvement effect in the prior art is solved, long-term effective visual improvement and visual fatigue relief are achieved, with high ingredient stability and accurate release.
Patent Information
- Application Number
- CN202510749695.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-06
- Publication Date
- 2025-08-12
AI Technical Summary
In the prior art, eye drops can only relieve visual fatigue in the short term, and it is difficult to improve vision from the root cause. There are toxic side effects of drug treatment, and the development of medicinal and food homologous compositions in improving vision is insufficient.
The medicinal and food homologous composition of wolfberry, locust flowers, mulberry, donkey-hide gelatin, poria, chrysanthemum, cassia seed, Buddha's hand, Dendrobium officinale, blueberry powder and composite particles is used. Combined with lutein ester microcapsule technology, the stable release of ingredients is ensured through double-layer embedding, the microcirculation and nerve metabolism of the eye are regulated, nutrients are supplemented, and visual fatigue is relieved.
It has achieved long-term effective improvement of vision, reduced damage to retinal cells by blue light and ultraviolet rays, enhanced eye tissue elasticity, relieve visual fatigue, and has high stability in components, accurate release, and significant effects.
Smart Images
Figure CN120459219A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medicine and food homology, and in particular to a medicine and food homology composition for improving eyesight and a preparation method thereof. Background Art
[0002] In recent years, with the changes in the social environment, the accelerated pace of work, the popularization of video terminals, the increase in people's spiritual needs, and the increasingly serious dependence on electronic products, the use of vision has become seriously overloaded. People's vision problems have also tended to increase gradually. Eye pain, photophobia, blurred vision and eye fatigue problems have become more and more obvious. Eye drops can only play a relieving role, and the effective time is short. It is difficult to improve vision from the root and solve the problem of eye fatigue.
[0003] There are also other medications available. Compared to medication, edible and medicinal combinations typically utilize natural foods and Chinese medicinal herbs, have minimal toxic side effects, and are relatively safe for long-term use. Traditional Chinese Medicine (TCM) theory posits that the eyes are closely connected to the body's internal organs and meridians. This approach focuses on a holistic approach, regulating the body's Qi and blood, as well as the function of its internal organs, to improve the eye's nutritional supply and function, achieving both symptomatic and fundamental treatment.
[0004] The raw materials of edible and medicinal products are mostly common food or medicinal materials in daily life. They can be made into drinks, foods, etc. for consumption. They are convenient and easy to be accepted by people. They are especially suitable for long-term conditioning. However, edible and medicinal compositions that can improve vision still need further development and research.
[0005] How to effectively improve vision through materials that are both medicinal and edible is a problem that needs to be solved by existing technologies. Summary of the Invention
[0006] The purpose of the present invention is to overcome the above technical deficiencies, provide a medicine-food composition for improving vision and a preparation method thereof, and solve the technical problem of how to effectively improve vision in the prior art.
[0007] In order to achieve the above technical objectives, the technical solution of the present invention provides a medicine-food composition for improving vision, the raw materials of which include: wolfberry, sophora japonica flower, mulberry, donkey-hide gelatin, Poria cocos, chrysanthemum, cassia seed, bergamot, dendrobium officinale, blueberry powder and composite particles; the composite particles include a capsule layer, a wrapping layer and lutein ester microcapsules from the outside to the inside.
[0008] In any embodiment, the raw materials include: 10-20 parts of wolfberry, 10-20 parts of Sophora japonica flower, 20-30 parts of mulberry, 10-15 parts of donkey-hide gelatin, 10-20 parts of Poria cocos, 20-30 parts of chrysanthemum, 5-10 parts of cassia seed, 10-15 parts of bergamot, 5-10 parts of dendrobium officinale, 5-10 parts of blueberry powder, and 30-50 parts of composite particles.
[0009] In any embodiment, 1-3 parts of vitamin C are also included.
[0010] In any embodiment, the lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, a first water and maltodextrin, and then spray drying to obtain the lutein ester microcapsules.
[0011] In any embodiment, the amount of the first starch added is 10-30% of the mass of the lutein ester; and / or the amount of the sunflower oil added is 5%-8% of the mass of the lutein ester; and / or the amount of the first water added is 30-40% of the first starch; and / or the amount of the maltodextrin added is 10-20% of the mass of the first water.
[0012] In any embodiment, the composite particles are prepared by the following steps:
[0013] The black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed, and then spray-dried to obtain the composite particles.
[0014] In any embodiment, the amount of the black sesame powder added is 30-40% of the mass of the lutein ester microcapsules; and / or the amount of the second starch added is 5-10% of the mass of the lutein ester microcapsules; and / or the amount of the second water added is 40-50% of the black sesame powder; and / or the amount of the xanthan gum added is 20-30% of the mass of the second water.
[0015] In any embodiment, the composite particles further include gum arabic and gelatin, and the preparation method includes: mixing the composite particles, gum arabic, gelatin and a third water, and then spray-drying the mixture.
[0016] In any embodiment, the lutein ester microcapsules further include Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics, and the lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, Lactobacillus acidophilus postbiotics, Lactobacillus rhamnosus postbiotics, a first water and maltodextrin, and then spray drying to obtain lutein ester microcapsules.
[0017] In addition, the present invention also provides a method for preparing the above-mentioned medicine-food composition for improving vision, comprising the following steps:
[0018] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:(5-6), boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a concentrated Chinese herbal medicine solution;
[0019] Melt donkey-hide gelatin with rice wine, stir in a 65-70℃ water bath until completely dissolved; the amount of rice wine used should be 1-2 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0020] Grind Poria cocos and Buddha's hand into powder;
[0021] Add the Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into the mixing tank, stir at a constant temperature of 55-60℃ and a stirring speed of 200-300rpm, add blueberry powder and lutein ester composite particles in sequence, continue stirring for 30-40 minutes, and then add water to adjust to a paste.
[0022] Compared with the existing technology, the beneficial effects of the present invention include: lutein esters, blueberry powder, vitamin C and other ingredients jointly eliminate free radicals and reduce the damage of blue light and ultraviolet rays to retinal cells; wolfberry, donkey-hide gelatin and other ingredients supplement vitamin A, fatty acids, amino acids and other nutrients; Poria cocos and bergamot regulate metabolism, improve ocular vascular microcirculation, and promote the delivery of nutrients to the retina; vitamin C enhances the elasticity and toughness of ocular tissues (such as lens and cornea); chrysanthemum, cassia seed, etc. regulate ocular nerve and body fluid metabolism and relieve visual fatigue through the liver-clearing and eyesight-improving effects in traditional Chinese medicine theory; through double-layer encapsulation technology, sensitive ingredients such as lutein esters are ensured to remain stable during storage and administration, and are accurately released to the site of action, maximizing their eye protection effects and achieving effective improvement in vision. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 Schematic diagram of the structure of the composite particles of Example 1 of the present invention.
[0024] Explanation of the accompanying symbols: 1. capsule layer; 2. wrapping layer; 3. lutein ester microcapsules. DETAILED DESCRIPTION
[0025] The "range" disclosed in this application is defined in the form of a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundaries of a particular range. The range defined in this way can be inclusive or exclusive of the end values, and can be arbitrarily combined, i.e., any lower limit can be combined with any upper limit to form a range. For example, if a range of 60 to 120 and 80 to 110 is listed for a particular parameter, it is understood that a range of 60 to 110 and 80 to 120 is also expected. In addition, if the minimum range values listed are 1 and 2, and if the maximum range values listed are 3, 4, and 5, then the following ranges can all be expected: 1 to 3, 1 to 4, 1 to 5, 2 to 3, 2 to 4, and 2 to 5. In this application, unless otherwise specified, the numerical range "a to b" represents an abbreviation of any real number combination between a and b, wherein a and b are both real numbers. For example, a numerical range of "0-5" indicates that all real numbers between "0-5" are listed herein, and "0-5" is simply an abbreviation for these numerical combinations. Furthermore, stating that a parameter is an integer ≥ 2 is equivalent to disclosing that the parameter is, for example, an integer of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.
[0026] Unless otherwise specified, the terms "include" and "comprising" used in this application may be open-ended or closed-ended. For example, "include" and "comprising" may mean that other components not listed may also be included or that only the listed components are included.
[0027] Unless otherwise specified, the term "or" is used in this application to be inclusive. For example, the phrase "A or B" means "A, B, or both A and B." More specifically, the condition "A or B" is satisfied if any of the following conditions are met: A is true (or exists) and B is false (or does not exist); A is false (or does not exist) and B is true (or exists); or both A and B are true (or exist).
[0028] This specific embodiment provides a medicine-food composition for improving vision, comprising wolfberry, sophora japonica flower, mulberry, donkey-hide gelatin, Poria cocos, chrysanthemum, cassia seed, bergamot, dendrobium officinale, blueberry powder, and composite particles; the composite particles comprise, from the outside to the inside, a capsule layer, a wrapping layer, and lutein ester microcapsules.
[0029] In some embodiments, the raw materials of the medicine-food composition for improving vision include: 10-20 parts of wolfberry, 10-20 parts of Sophora japonica flower, 20-30 parts of mulberry, 10-15 parts of donkey-hide gelatin, 10-20 parts of Poria cocos, 20-30 parts of chrysanthemum, 5-10 parts of cassia seed, 10-15 parts of bergamot, 5-10 parts of Dendrobium officinale, 5-10 parts of blueberry powder, and 30-50 parts of composite particles.
[0030] In some embodiments, the food-medicine composition for improving vision further comprises 1-3 portions of vitamin C.
[0031] In some embodiments, the lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, a first water and maltodextrin, and then spray drying to obtain lutein ester microcapsules; the amount of the first starch added is 10-30% of the mass of the lutein ester, the amount of the sunflower oil added is 5%-8% of the mass of the lutein ester; the amount of the first water added is 30-40% of the first starch; and the amount of the maltodextrin added is 10-20% of the mass of the first water.
[0032] In some embodiments, the composite particles are prepared by the following steps:
[0033] Black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed, and then spray-dried to obtain the composite particles; the added amount of the black sesame powder is 30-40% of the mass of the lutein ester microcapsules; the added amount of the second starch is 5-10% of the mass of the lutein ester microcapsules, the added amount of the second water is 40-50% of the mass of the black sesame powder, and the added amount of the xanthan gum is 20-30% of the mass of the second water.
[0034] The lipid components of black sesame powder and the colloidal properties of xanthan gum can further isolate the external environment and prevent the microcapsules from dissolving in the paste due to changes in humidity and pH value; lutein ester can also slow down the release rate under the action of the first starch and sunflower oil. The intestines first digest and absorb the components in the paste and other components of the composite particles. Lutein ester can continue in a slow manner, which is more conducive to the efficiency of effective components reaching the eye tissue.
[0035] In some embodiments, the lutein ester microcapsules further include Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics. The lutein ester microcapsules are prepared by mixing lutein ester, sunflower seed oil, a first starch, Lactobacillus acidophilus postbiotics, Lactobacillus rhamnosus postbiotics, a first water, and maltodextrin, followed by spray drying to obtain lutein ester microcapsules; the Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics are added in amounts of 5-10% by weight of the lutein ester, respectively. The Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics can also be sustained-released along with the lutein esters, and the more water-soluble Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics are preferentially sustained-released, taking the lead in regulating the intestinal environment and creating favorable conditions for the absorption of the lutein esters.
[0036] In some embodiments, the composite particles further include gum arabic and gelatin, and the preparation method includes: mixing the composite particles, gum arabic, gelatin and a third water, and then spray drying.
[0037] This specific embodiment also provides a method for preparing the above-mentioned medicine-food composition for improving vision, comprising the following steps:
[0038] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:(5-6), boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a concentrated Chinese herbal medicine solution;
[0039] Melt donkey-hide gelatin with rice wine, stir in a 65-70℃ water bath until completely dissolved; the amount of rice wine used should be 1-2 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0040] Grind Poria cocos and Buddha's hand into powder, pass through 100 mesh fine powder and set aside;
[0041] Pass the blueberry powder through an 80-mesh sieve to avoid lumps;
[0042] The composite particles were passed through a 60-mesh sieve to ensure dispersion;
[0043] Add the Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria cocos powder, and bergamot powder into the mixing tank, stir at a constant temperature of 55-60℃ and a stirring speed of 200-300rpm, add blueberry powder and lutein ester composite particles in sequence, continue stirring for 30-40 minutes, and then add appropriate amount of water to adjust to a paste.
[0044] In some embodiments, vitamin C is further added before adding an appropriate amount of water to adjust the mixture to a paste state.
[0045] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.
[0046] In the present invention, references to “some embodiments”, “this embodiment”, examples, etc. describe a subset of all possible embodiments, but it can be understood that “some embodiments” may be the same subset or different subsets of all possible embodiments, and may be combined with each other without conflict.
[0047] If similar descriptions of "first / second" appear in the application documents, the following explanation is added. In the following description, the terms "first\second\third" are merely used to distinguish similar objects and do not represent a specific order of the objects. It can be understood that "first\second\third" can be interchanged with the specific order or sequence where permitted, so that the embodiments described herein can be implemented in an order other than that illustrated or described herein.
[0048] In this embodiment, the term "and / or" is merely a description of the association relationship between associated objects, indicating that three relationships may exist. For example, object A and / or object B may represent three situations: object A exists alone, object A and object B exist at the same time, and object B exists alone.
[0049] Below, the embodiment of the present application is described. The embodiment described below is exemplary and is only used to explain the present application, and should not be construed as limiting the present application. Where specific techniques or conditions are not specified in the embodiments, the techniques or conditions described in the literature in this area or the product specifications are used. Reagents or instruments used that do not specify the manufacturer are conventional products that can be obtained commercially. It should be noted that the raw materials of the following embodiments or comparative examples are all from the prior art.
[0050] Example 1
[0051] This embodiment provides a medicine-food combination for improving vision, the raw materials including: 10 parts of wolfberry, 20 parts of Sophora japonica flower, 25 parts of mulberry, 10 parts of donkey-hide gelatin, 15 parts of Poria cocos, 25 parts of chrysanthemum, 5 parts of cassia seed, 12 parts of bergamot, 8 parts of dendrobium officinale, 5 parts of blueberry powder, 40 parts of composite particles and 1 part of vitamin C; combined with Figure 1 The composite particles include a capsule layer 1, a wrapping layer 2 and lutein ester microcapsules 3 from the outside to the inside.
[0052] In this embodiment, the lutein ester microcapsules are prepared by the following steps: lutein ester, sunflower oil, a first starch, a first water, and maltodextrin are mixed, and then spray-dried to obtain lutein ester microcapsules; the amount of the first starch added is 10% of the mass of the lutein ester, the amount of the sunflower oil added is 5% of the mass of the lutein ester; the amount of the first water added is 35% of the mass of the first starch; and the amount of the maltodextrin added is 20% of the mass of the first water.
[0053] The composite particles of this embodiment are prepared by the following steps:
[0054] Black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed and then spray-dried to obtain the composite particles; the amount of the black sesame powder added is 35% of the mass of the lutein ester microcapsules; the amount of the second starch added is 8% of the mass of the lutein ester microcapsules, the amount of the second water added is 45% of the black sesame powder, and the amount of the xanthan gum added is 25% of the mass of the second water.
[0055] This embodiment also provides a method for preparing the above-mentioned medicine-food composition for improving vision, comprising the following steps:
[0056] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:5, boil and extract twice, each time for 1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1 to obtain a Chinese herbal medicine concentrate;
[0057] Melt donkey-hide gelatin with yellow rice wine, stir in a 70℃ water bath until completely dissolved; the amount of yellow rice wine used should be 1 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0058] Grind Poria cocos and Buddha's hand into powder, pass through 100 mesh fine powder and set aside;
[0059] Pass the blueberry powder through an 80-mesh sieve to avoid lumps;
[0060] The composite particles were passed through a 60-mesh sieve to ensure dispersion;
[0061] Add Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into a mixing tank, stir at a constant temperature of 60°C and a stirring speed of 200-300rpm, add blueberry powder, vitamin C, and composite particles in turn, continue stirring for 30 minutes, and then add appropriate amount of water to adjust to a paste.
[0062] Example 2
[0063] This embodiment provides a medicinal and edible composition for improving vision, the raw materials including: 20 parts of wolfberry, 10 parts of Sophora japonica flower, 30 parts of mulberry, 12 parts of donkey-hide gelatin, 20 parts of Poria cocos, 20 parts of chrysanthemum, 8 parts of cassia seed, 15 parts of bergamot, 10 parts of Dendrobium officinale, 8 parts of blueberry powder, 30 parts of composite particles and 2 parts of vitamin C; the composite particles include, from the outside to the inside, a capsule layer, a wrapping layer and lutein ester microcapsules.
[0064] In this embodiment, the lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, a first water, and maltodextrin, and then spray drying to obtain lutein ester microcapsules; the amount of the first starch added is 20% of the mass of the lutein ester, the amount of the sunflower oil added is 6% of the mass of the lutein ester; the amount of the first water added is 40% of the mass of the first starch; and the amount of the maltodextrin added is 10% of the mass of the first water;
[0065] The composite particles of this embodiment are prepared by the following steps:
[0066] Black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed and then spray-dried to obtain the composite particles; the amount of the black sesame powder added is 40% of the mass of the lutein ester microcapsules; the amount of the second starch added is 5% of the mass of the lutein ester microcapsules, the amount of the second water added is 40% of the mass of the black sesame powder, and the amount of the xanthan gum added is 30% of the mass of the second water.
[0067] This embodiment also provides a method for preparing the above-mentioned medicine-food composition for improving vision, comprising the following steps:
[0068] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:5, boil and extract twice, each time for 1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.2 to obtain a Chinese herbal medicine concentrate;
[0069] Melt donkey-hide gelatin with yellow rice wine, stir in a 70℃ water bath until completely dissolved; the amount of yellow rice wine used should be 1.5 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0070] Grind Poria cocos and Buddha's hand into powder, pass through 100 mesh fine powder and set aside;
[0071] Pass the blueberry powder through an 80-mesh sieve to avoid lumps;
[0072] The composite particles were passed through a 60-mesh sieve to ensure dispersion;
[0073] Add Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into a mixing tank, stir at a constant temperature of 55°C and a stirring speed of 200-300rpm, add blueberry powder, vitamin C, and composite particles in turn, continue stirring for 35 minutes, and then add appropriate amount of water to adjust to a paste.
[0074] Example 3
[0075] This embodiment provides a medicinal and edible composition for improving vision, the raw materials including: 15 parts of wolfberry, 15 parts of Sophora japonica flower, 20 parts of mulberry, 15 parts of donkey-hide gelatin, 10 parts of Poria cocos, 30 parts of chrysanthemum, 10 parts of cassia seed, 10 parts of bergamot, 5 parts of dendrobium officinale, 10 parts of blueberry powder, 50 parts of composite particles and 3 parts of vitamin C; the composite particles include, from the outside to the inside, a capsule layer, a wrapping layer and lutein ester microcapsules.
[0076] In this embodiment, the lutein ester microcapsules are prepared by the following steps: lutein ester, sunflower oil, a first starch, a first water and maltodextrin are mixed, and then spray-dried to obtain lutein ester microcapsules; the amount of the first starch added is 30% of the mass of the lutein ester, the amount of the sunflower oil added is 8% of the mass of the lutein ester; the amount of the first water added is 30% of the mass of the first starch; and the amount of the maltodextrin added is 15% of the mass of the first water.
[0077] The composite particles of this embodiment are prepared by the following steps:
[0078] Black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed and then spray-dried to obtain the composite particles; the amount of the black sesame powder added is 30% of the mass of the lutein ester microcapsules; the amount of the second starch added is 10% of the mass of the lutein ester microcapsules, the amount of the second water added is 50% of the black sesame powder, and the amount of the xanthan gum added is 20% of the mass of the second water.
[0079] This embodiment also provides a method for preparing the above-mentioned medicine-food composition for improving vision, comprising the following steps:
[0080] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:6, boil and extract twice, each time for 1 hour, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1 to obtain a concentrated Chinese herbal medicine solution;
[0081] Melt donkey-hide gelatin with yellow rice wine, stir in a 65℃ water bath until completely dissolved; the amount of yellow rice wine used should be 2 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0082] Grind Poria cocos and Buddha's hand into powder, pass through 100 mesh fine powder and set aside;
[0083] Pass the blueberry powder through an 80-mesh sieve to avoid lumps;
[0084] The composite particles were passed through a 60-mesh sieve to ensure dispersion;
[0085] Add Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into a mixing tank, stir at a constant temperature of 60°C and a stirring speed of 200-300rpm, add blueberry powder, vitamin C, and composite particles in turn, continue stirring for 40 minutes, and then add appropriate amount of water to adjust to a paste.
[0086] Example 4
[0087] The difference between this embodiment and Example 1 is that the lutein ester microcapsules further include Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics, and the lutein ester microcapsules are prepared by the following steps: lutein ester, sunflower seed oil, a first starch, Lactobacillus acidophilus postbiotics, Lactobacillus rhamnosus postbiotics, a first water and maltodextrin are mixed, and then spray-dried to obtain lutein ester microcapsules; the added amounts of the Lactobacillus acidophilus postbiotics and the Lactobacillus rhamnosus postbiotics are respectively 8% of the mass of the lutein ester.
[0088] The preparation method of the composite particles of this embodiment is the same as that of Example 1.
[0089] The raw material composition and preparation method of the medicine-food combination of this embodiment are the same as those in Example 1.
[0090] Example 5
[0091] The difference between this embodiment and Example 1 is that the lutein ester microcapsules further include Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics, and the lutein ester microcapsules are prepared by the following steps: lutein ester, sunflower seed oil, a first starch, Lactobacillus acidophilus postbiotics, Lactobacillus rhamnosus postbiotics, a first water and maltodextrin are mixed, and then spray-dried to obtain lutein ester microcapsules; the added amounts of the Lactobacillus acidophilus postbiotics and the Lactobacillus rhamnosus postbiotics are respectively 10% of the mass of the lutein ester.
[0092] The preparation method of the composite particles of this embodiment is the same as that of Example 1.
[0093] The raw material composition and preparation method of the medicine-food combination of this embodiment are the same as those in Example 1.
[0094] Comparative Example 1
[0095] The difference between the medicine-food composition of this comparative example and that of Example 4 is that the composite particles of Example 4 are missing.
[0096] The preparation method of the medicine-food composition of this comparative example comprises the following steps:
[0097] Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:5, boil and extract twice, each time for 1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1 to obtain a Chinese herbal medicine concentrate;
[0098] Melt donkey-hide gelatin with yellow rice wine, stir in a 70℃ water bath until completely dissolved; the amount of yellow rice wine used should be 1 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution;
[0099] Grind Poria cocos and Buddha's hand into powder, pass through 100 mesh fine powder and set aside;
[0100] Pass the blueberry powder through an 80-mesh sieve to avoid lumps;
[0101] Add Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into a mixing tank, stir at a constant temperature of 60°C and a stirring speed of 200-300rpm, add blueberry powder and vitamin C in turn, continue stirring for 30 minutes, and then add appropriate amount of water to adjust to a paste.
[0102] Comparative Example 2
[0103] The difference between the medicine-food composition of this comparative example and that of Example 4 is that it only contains the composite particles of Example 4 and does not contain other Chinese medicinal materials.
[0104] Related trials
[0105] Experimental method: The efficacy of the present invention was tested with reference to the test method for relieving visual fatigue in the Technical Specifications for Inspection and Evaluation of Health Food.
[0106] Subject selection and grouping: 140 subjects, aged 25-40 years old, were divided equally among the subjects aged 25-40 years old into 7 groups, with 20 subjects in each group. The subjects were those who frequently used mobile phones and / or computers and had symptoms of visual fatigue. They had not taken health products or functional foods to relieve visual fatigue within three months. It should be noted that those with visual fatigue symptoms showed eye pain, photophobia and blurred vision. The 7 groups of subjects took the products of Examples 1-5 and Comparative Examples 1-2, once a day in the morning and evening, 20g each time. Each group took the relevant products continuously for 15 days.
[0107] Criteria for judging efficacy: observe the subjects' three symptoms: eye pain, photophobia, and blurred vision.
[0108] Significant improvement: eye pain, photophobia, and blurred vision were improved, and no symptoms worsened.
[0109] Improvement: Two of the following symptoms, eye pain, photophobia, and blurred vision, improved, and no symptoms worsened.
[0110] Ineffective: There was no improvement in the three symptoms of eye pain, photophobia, and blurred vision.
[0111] Testing methods and evaluation results: Before taking the drug and one month after taking it, each group of people were evaluated for their own symptom improvement. The evaluation results of symptoms such as eye pain, photophobia, and blurred vision in each group are shown in Table 1 and Table 2. It should be noted that the obvious improvement rate = number of people who improved ÷ total number of people * 100%; the improvement rate = number of people who improved ÷ total number of people * 100%; the ineffective rate = number of people who had no effect ÷ total number of people * 100%
[0112] Table 1 Improvement after 15 days of use
[0113]
[0114] Table 2 Improvement after taking the medicine for 30 days
[0115]
[0116] As can be seen from Table 1, after taking the product of Example 4-5 for 15 days, the improvement rate was significantly higher than that of Example 1-3. As can be seen from Table 2, after taking the product of Example 4-5 for 30 days, the improvement rate was as high as 95%, which was significantly higher than that of Example 1-3.
[0117] We found that the capsule layer of the composite particles of the products of Examples 1-5 dissolved after 2 months of storage. To solve this problem, we conducted extensive research and found that adding gum arabic and gelatin to the composite particles could extend the storage time of the products to 6 months, as follows:
[0118] Example 6
[0119] This embodiment provides a medicine-food composition for improving vision, the raw materials including: 10 parts of wolfberry, 20 parts of Sophora japonica flower, 25 parts of mulberry, 10 parts of donkey-hide gelatin, 15 parts of Poria cocos, 25 parts of chrysanthemum, 5 parts of cassia seed, 12 parts of bergamot, 8 parts of Dendrobium officinale, 5 parts of blueberry powder, 40 parts of composite particles and 1 part of vitamin C; the composite particles include, from the outside to the inside, a capsule layer, a wrapping layer and lutein ester microcapsules.
[0120] The lutein ester microcapsules are prepared by the following steps: lutein ester, sunflower oil, a first starch, a Lactobacillus acidophilus postbiotic, a Lactobacillus rhamnosus postbiotic, a first water and maltodextrin are mixed, and then spray-dried to obtain the lutein ester microcapsules; the added amount of the Lactobacillus acidophilus postbiotic and the Lactobacillus rhamnosus postbiotic are 8% of the mass of the lutein ester respectively; the added amount of the first starch is 10% of the mass of the lutein ester, the monoglyceride is 5% of the total mass of the sunflower oil and the lutein ester; the added amount of the first water is 35% of the mass of the first starch; and the added amount of the maltodextrin is 20% of the mass of the first water;
[0121] The composite particles in this embodiment are prepared by the following steps: black sesame powder, lutein ester microcapsules, a second starch, xanthan gum, and a second water are mixed, and then spray-dried to obtain the composite particles; the amount of the black sesame powder added is 35% of the mass of the lutein ester microcapsules; the amount of the second starch added is 8% of the mass of the lutein ester microcapsules; the amount of the second water added is 45% of the mass of the black sesame powder; and the amount of the xanthan gum added is 25% of the mass of the second water;
[0122] The composite particles, gum arabic, gelatin and third water are mixed and then spray-dried to obtain the composite material; the amount of the third water added is 20% of the composite material, the amount of the gum arabic added is 30% of the mass of the third water, and the amount of the gelatin added is 10% of the mass of the third water.
[0123] The preparation method of the medicine-food composition of this embodiment is the same as that of Example 1.
[0124] The storage time of Example 4 and Example 6 is compared, as shown in Table 3.
[0125] Table 3
[0126]
[0127] The specific embodiments of the present invention described above do not limit the scope of protection of the present invention. Any other corresponding changes and modifications made based on the technical concept of the present invention should be included in the scope of protection of the claims of the present invention.
Claims
1. A medicinal and edible composition for improving vision, characterized in that: The raw materials include: wolfberry, sophora japonica flower, mulberry, donkey-hide gelatin, poria cocos, chrysanthemum, cassia seed, bergamot, dendrobium officinale, blueberry powder and composite particles; the composite particles include a capsule layer, a wrapping layer and lutein ester microcapsules from the outside to the inside.
2. The medicine-food composition for improving eyesight according to claim 1, characterized in that: The raw materials include: 10-20 parts of wolfberry, 10-20 parts of Sophora japonica flower, 20-30 parts of mulberry, 10-15 parts of donkey-hide gelatin, 10-20 parts of Poria cocos, 20-30 parts of chrysanthemum, 5-10 parts of cassia seed, 10-15 parts of bergamot, 5-10 parts of dendrobium officinale, 5-10 parts of blueberry powder, and 30-50 parts of composite particles.
3. The medicine-food composition for improving eyesight according to claim 2, characterized in that: Also includes 1-3 servings of Vitamin C.
4. The medicine-food composition for improving eyesight according to claim 1, characterized in that: The lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, a first water and maltodextrin, and then spray-drying to obtain the lutein ester microcapsules.
5. The medicine-food composition for improving eyesight according to claim 4, characterized in that: The amount of the first starch added is 10-30% of the mass of the lutein ester; and / or the amount of the sunflower oil added is 5%-8% of the mass of the lutein ester; and / or the amount of the first water added is 30-40% of the first starch; and / or the amount of the maltodextrin added is 10-20% of the mass of the first water.
6. The medicine-food composition for improving eyesight according to claim 1, characterized in that: The composite particles are prepared by the following steps: The black sesame powder, lutein ester microcapsules, a second starch, xanthan gum and a second water are mixed, and then spray-dried to obtain the composite particles.
7. The medicine-food composition for improving eyesight according to claim 6, characterized in that: The amount of the black sesame powder added is 30-40% of the mass of the lutein ester microcapsules; and / or the amount of the second starch added is 5-10% of the mass of the lutein ester microcapsules; and / or the amount of the second water added is 40-50% of the black sesame powder; and / or the amount of the xanthan gum added is 20-30% of the mass of the second water.
8. The medicine-food composition for improving eyesight according to claim 6, characterized in that: The composite particles also include gum arabic and gelatin, and the preparation method includes: mixing the composite particles, gum arabic, gelatin and third water, and then spray drying.
9. The medicine-food composition for improving eyesight according to claim 4, characterized in that: The lutein ester microcapsules also include Lactobacillus acidophilus postbiotics and Lactobacillus rhamnosus postbiotics. The lutein ester microcapsules are prepared by the following steps: mixing lutein ester, sunflower oil, a first starch, Lactobacillus acidophilus postbiotics, Lactobacillus rhamnosus postbiotics, a first water and maltodextrin, and then spray drying to obtain the lutein ester microcapsules.
10. A method for preparing the medicine-food composition for improving vision according to any one of claims 1 to 9, characterized in that: The following steps are involved: Add wolfberry fruit, Sophora japonica flower, mulberry fruit, cassia seed, chrysanthemum and Dendrobium officinale to water at a material-liquid ratio of 1:(5-6), boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a concentrated Chinese herbal medicine solution; Melt donkey-hide gelatin with rice wine, stir in a 65-70℃ water bath until completely dissolved; the amount of rice wine used should be 1-2 times the mass of donkey-hide gelatin to obtain donkey-hide gelatin solution; Crush Poria cocos and Buddha's hand into powder; Add the Chinese herbal medicine concentrate, donkey-hide gelatin solution, Poria powder, and bergamot powder into the mixing tank, stir at a constant temperature of 55-60℃ and a stirring speed of 200-300rpm, add blueberry powder and lutein ester composite particles in sequence, continue stirring for 30-40 minutes, and then add water to adjust to a paste.