Traditional Chinese medicine composition as well as preparation method and application thereof

Abstract

The invention provides a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises more than 30 Chinese herbal medicines such as radix bupleuri, murraya paniculata, codonopsis pilosula, allium macrostemon and cassia twig. The traditional Chinese medicine composition is mainly used for strengthening the spleen, excreting dampness, promoting intestinal tract movement and recovering normal operation of a nutrient absorption function, regulating normal operation of a digestion and absorption system of a human body and promoting transportation and transformation of the spleen and the small intestine by gradually controlling the pathogenesis of aplastic anemia, and plays a coordination and comprehensive treatment role from regenerated marrow to regenerated blood; and the pathogenesis of aplastic anemia is radically and thoroughly reversed, so that the body achieves the purpose of natural rehabilitation.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition and a preparation method and application thereof. Background Art

[0002] Aplastic anemia, also known as AA, is a complex disease characterized by a decrease in the number of peripheral blood cells (pancytopenia) due to a decrease in the bone marrow's hematopoietic tissue and hematopoietic failure. It can be categorized as either acute or chronic based on the speed of disease progression and severity, combined with blood and bone marrow findings. If a causative factor, such as drugs, chemicals, radiation, or infection, is identified, the disease is considered secondary. Clinically, it often presents with severe anemia, bleeding, and infection. Primary AA is more common in men than women, and more common in young people than in the elderly.

[0003] The main causes of aplastic anemia include functional malabsorption of the spleen and small intestine and parasitic infection. Treatment options for aplastic anemia include blood transfusions, hemostatic drugs, antifibrinolytic drugs, liver-protective drugs or antibiotics, and androgen drugs. However, these treatments are not ideal and cannot provide a complete cure.

[0004] Therefore, it is very necessary to provide a Chinese medicine composition with better therapeutic effect. Summary of the Invention

[0005] The purpose of the present invention is to provide a traditional Chinese medicine composition and its preparation method and application, wherein the traditional Chinese medicine composition can remove intestinal waste, toxins and parasites, and treat both the symptoms and the root cause, so that the absorption and transportation functions of the small intestine and spleen are restored to normal, and then the marrow-forming functions of the small intestine and spleen are restored to normal, thereby achieving the purpose of bone marrow and blood regeneration.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a traditional Chinese medicine composition comprising the following raw material components in parts by weight:

[0008] 10-15 parts of Bupleurum, 40-45 parts of Murraya Osmanthus, 10-15 parts of Codonopsis pilosula, 10-15 parts of Allium macrostemon, 10-15 parts of Cinnamon twig, 10-15 parts of Poria, 40-45 parts of Coix seeds, 10-15 parts of Apricot kernel, 40-45 parts of Atractylodes macrocephala, 10-15 parts of Poria, 10-15 parts of Tangerine peel, 55-65 parts of Ginkgo, 15-25 parts of Indigo naturalis, 10-15 parts of Cortex Moutan, 40- 45 parts, 5-8 parts of Coptis chinensis, 40-45 parts of Scutellaria barbata, 60-70 parts of Smilax china, 175-185 parts of Humu root, 55-65 parts of Cyperus rotundus, 15-25 parts of Thunder Ball, 15-25 parts of Sophora flavescens, 5-8 parts of Cannabis sativa seeds, 5-8 parts of Heichou, 5-8 parts of Costus root, 5-8 parts of Heshi, 5-8 parts of Areca catechu, 5-8 parts of Plum, 5-8 parts of Hexagram glutinosa, 5-8 parts of Tianmingjing, and 5-8 parts of Evodia rutaecarpa.

[0009] Preferably, the raw material components include the following parts by mass:

[0010] 12-14 parts of Bupleurum, 42-44 parts of Murraya Osmanthus, 12-14 parts of Codonopsis pilosula, 12-14 parts of Allium macrostemon, 12-14 parts of Cinnamon twig, 12-14 parts of Poria, 42-44 parts of Coix seeds, 12-14 parts of Apricot kernel, 42-44 parts of Atractylodes macrocephala, 12-14 parts of Poria, 12-14 parts of Tangerine peel, 56-64 parts of Ginkgo, 16-24 parts of Indigo, 12-14 parts of Cortex Moutan, 42-14 parts of Hedyotis diffusa. 44 parts, 6-7 parts of Coptis chinensis, 42-44 parts of Scutellaria barbata, 62-68 parts of Smilax china, 176-184 parts of Humu root, 56-64 parts of Cyperus rotundus, 16-24 parts of Thunder Ball, 16-24 parts of Sophora flavescens, 6-7 parts of Cannabis sativa seeds, 6-7 parts of Heichou, 6-7 parts of Costus root, 6-7 parts of Heshi, 6-7 parts of Areca catechu, 6-7 parts of Plum, 6-7 parts of Hexagram glutinosa, 6-7 parts of Tianmingjing, and 6-7 parts of Evodia rutaecarpa.

[0011] Preferably, the dosage form of the traditional Chinese medicine composition includes granules and capsules.

[0012] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0013] The raw material components of the traditional Chinese medicine composition are dried, crushed and mixed respectively to obtain the traditional Chinese medicine composition.

[0014] Preferably, the drying temperature is 50-60° C., and the drying time is 24-48 hours.

[0015] Preferably, the pulverization is followed by filtering using a 100-130 mesh sieve.

[0016] The present invention also provides the use of the traditional Chinese medicine composition in preparing medicine for treating aplastic anemia.

[0017] The beneficial effects of the present invention compared with the prior art are:

[0018] The Chinese medicine composition provided by the present invention can comprehensively adjust the operation and coordination of qi among various organs of the human body, and can jointly complete the metabolism of the entire body; by strengthening the spleen and eliminating dampness, promoting intestinal peristalsis, and eliminating parasites, the various digestive organs of the human body tend to function normally, thereby significantly improving the absorption capacity of the spleen and small intestine for nutrients.

[0019] After patients with aplastic anemia take Xuefukang for 1-2 courses (1 course is 1 month), the effective active molecules in the drug enter the digestive system and reach the diseased area directly, clearing out intestinal waste, toxins and parasites, allowing the absorption and transportation functions of the spleen and small intestine to return to normal, and then promoting the restoration of normal bone marrow hematopoietic function, thereby achieving the purpose of blood regeneration.

[0020] The present invention focuses on strengthening the spleen and dispelling dampness, promoting intestinal motility and restoring the normal function of nutrient absorption. By gradually controlling the pathogenesis of aplastic anemia, regulating the normal function of the human digestive and absorption system, promoting the transportation and transformation of the spleen and small intestine, and playing a coordinated and comprehensive therapeutic role in regenerating marrow to regenerate blood, the pathogenesis of aplastic anemia is fundamentally reversed, allowing the body to achieve the goal of natural recovery. The traditional Chinese medicine composition addresses the root cause of aplastic anemia, achieving multiple functions such as regenerating marrow to regenerate blood, restoring the normal function of the human digestive and absorption function, and overall regulating complications.

[0021] The Chinese medicine composition provided by the present invention has the following characteristics: 1. Treating both the symptoms and the root cause. The small intestine, as the "organ of receiving and storing", is the core link of the digestive system and has multiple functions of transformation, absorption and excretion. It breaks through the limitations of traditional treatment and can protect the spleen and intestines to absorb nutrients normally while treating aplastic anemia; 2. Strengthening the spleen and stomach, so that the small intestine can move normally to absorb nutrients, breaking the traditional shortcomings of stimulating blood production or directly transfusing blood due to the inability to produce blood independently; the spleen and stomach are collectively called "organs of granary", and jointly undertake the functions of digestion, absorption and nutrient distribution of food. The stomach is responsible for receiving and is responsible for the initial digestion of food; the spleen is responsible for transportation and transformation; the small intestine is responsible for multiple functions of transformation, absorption and excretion; the spleen, stomach and small intestine jointly transform water and grain into qi and blood essence to nourish the bones and bones of the whole body; it emphasizes the regulation of the spleen ③ Multi-drug therapy breaks with conventional treatment methods, using multiple drugs to target the affected area, improve digestion and absorption, regulate organ metabolism, correct the balance of yin and yang, and alleviate anemia caused by malnutrition-induced bone marrow mutations, thereby restoring the spleen and small intestine's ability to absorb nutrients and regenerate marrow and blood. ④ After medication, the drug's properties are slowly released, balancing digestion and absorption, gradually restoring normal spleen and small intestine function until recovery is complete and lasting. ⑤ Long-term medication is not required. Once the active molecules in the drug enter the body, they activate and regulate the disrupted digestive and absorption system, allowing the organs to function normally. After one or two courses of oral administration, the body's digestive and absorption functions are restored, anemia returns to normal, and this is consolidated, allowing withdrawal from medication without relapse, ultimately leading to a healthy state.

[0022] The present invention starts from the root cause of aplastic anemia and is developed for the transformation of complications. It uses a variety of drugs to comprehensively regulate the human body's digestive and absorption system, strengthen the spleen and promote intestinal peristalsis, clear toxins and parasites in the intestine, restore the digestive and absorption function of the intestine, and fundamentally reverse the pathogenesis of aplastic anemia to achieve the purpose of recovery.

[0023] The present invention focuses on tonifying qi and strengthening the spleen, promoting intestinal motility and nutrient absorption, distinguishing deficiency and excess, and achieving the effects of clearing away heat and detoxifying, promoting qi and relieving pain, activating blood circulation and dispersing blood stasis, evacuating and reducing fever, tonifying qi and strengthening the spleen, and comprehensively conditioning the digestive organs; killing parasites and eliminating accumulation, moistening the intestines and promoting bowel movements, cooling blood and stopping bleeding, and promoting blood circulation; eliminating heat and detoxifying, and fighting cancer, and promoting the radical cure of aplastic anemia. The traditional Chinese medicine composition is easy to use, has stable efficacy, and is free of toxic side effects. DETAILED DESCRIPTION

[0024] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0025] It should be understood that the terms described herein are intended only to describe particular embodiments and are not intended to limit the present invention. In addition, for numerical ranges herein, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each smaller range between any intermediate value within a stated value or stated range and any other stated value or intermediate value within the stated range is also encompassed by the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the scope.

[0026] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of any conflict with any incorporated document, the contents of this specification shall prevail.

[0027] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from the description of the invention. The description and examples are intended to be exemplary only.

[0028] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0029] The present invention provides a traditional Chinese medicine composition comprising the following raw material components in parts by weight:

[0030] 10-15 parts of Bupleurum, 40-45 parts of Murraya Osmanthus, 10-15 parts of Codonopsis pilosula, 10-15 parts of Allium macrostemon, 10-15 parts of Cinnamon twig, 10-15 parts of Poria, 40-45 parts of Coix seeds, 10-15 parts of Apricot kernel, 40-45 parts of Atractylodes macrocephala, 10-15 parts of Poria, 10-15 parts of Tangerine peel, 55-65 parts of Ginkgo, 15-25 parts of Indigo naturalis, 10-15 parts of Cortex Moutan, 40- 45 parts, 5-8 parts of Coptis chinensis, 40-45 parts of Scutellaria barbata, 60-70 parts of Smilax china, 175-185 parts of Humu root, 55-65 parts of Cyperus rotundus, 15-25 parts of Thunder Ball, 15-25 parts of Sophora flavescens, 5-8 parts of Cannabis sativa seeds, 5-8 parts of Heichou, 5-8 parts of Costus root, 5-8 parts of Heshi, 5-8 parts of Areca catechu, 5-8 parts of Plum, 5-8 parts of Hexagram glutinosa, 5-8 parts of Tianmingjing, and 5-8 parts of Evodia rutaecarpa.

[0031] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of bupleurum, preferably 12 to 14 parts, and more preferably 13 parts; the bupleurum can play a role in dispersing and reducing fever in the traditional Chinese medicine composition.

[0032] In the present invention, the traditional Chinese medicine composition comprises 40 to 45 parts of Murraya odorata, preferably 42 to 44 parts, and more preferably 43 parts; Murraya odorata can play the role of promoting qi and relieving pain, promoting blood circulation and removing blood stasis in the traditional Chinese medicine composition.

[0033] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of Codonopsis pilosula, preferably 12 to 14 parts, and more preferably 13 parts; the Codonopsis pilosula can play the role of replenishing Qi and strengthening the spleen in the traditional Chinese medicine composition.

[0034] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of Xiebai, preferably 12 to 14 parts, and more preferably 13 parts; the Xiebai can play a role in dispersing stagnation in the traditional Chinese medicine composition.

[0035] In the present invention, the traditional Chinese medicine composition includes 10 to 15 parts of cassia twig, preferably 12 to 14 parts, and more preferably 13 parts; the cassia twig can promote blood circulation in the traditional Chinese medicine composition.

[0036] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of Poria cocos, preferably 12 to 14 parts, and more preferably 13 parts; the Poria cocos can play the role of strengthening the spleen, promoting diuresis and eliminating dampness in the traditional Chinese medicine composition.

[0037] In the present invention, the traditional Chinese medicine composition comprises 40 to 45 parts of coix seed, preferably 42 to 44 parts, and more preferably 43 parts; the coix seed can play the role of strengthening the spleen and dispelling dampness in the traditional Chinese medicine composition.

[0038] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of almonds, preferably 12 to 14 parts, and more preferably 13 parts; the almonds can play a role in moistening the intestines and promoting bowel movements in the traditional Chinese medicine composition.

[0039] In the present invention, the traditional Chinese medicine composition includes 40 to 45 parts of Atractylodes macrocephala, preferably 42 to 44 parts, and more preferably 43 parts; the Atractylodes macrocephala in the traditional Chinese medicine composition can enhance the spleen and stomach function and promote digestion and absorption.

[0040] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of Poria cocos, preferably 12 to 14 parts, and more preferably 13 parts; the Poria cocos can play the role of strengthening the spleen and benefiting the small intestine in the traditional Chinese medicine composition.

[0041] In the present invention, the traditional Chinese medicine composition comprises 10 to 15 parts of dried tangerine peel, preferably 12 to 14 parts, and more preferably 13 parts; the dried tangerine peel in the traditional Chinese medicine composition can promote intestinal peristalsis.

[0042] In the present invention, the traditional Chinese medicine composition includes 55 to 65 parts of ginkgo nuts, preferably 56 to 64 parts, more preferably 58 to 62 parts, and even more preferably 60 parts; the ginkgo nuts in the traditional Chinese medicine composition can play a role in unblocking blood vessels.

[0043] In the present invention, the traditional Chinese medicine composition comprises 15 to 25 parts of Indigo Naturalis, preferably 16 to 24 parts, more preferably 18 to 22 parts, and even more preferably 20 parts; the Indigo Naturalis can play a role in cooling blood and stopping bleeding in the traditional Chinese medicine composition.

[0044] In the present invention, the Chinese medicine composition comprises 10 to 15 parts of moutan bark, preferably 12 to 14 parts, and more preferably 13 parts; the moutan bark can cool blood, stop bleeding and promote blood circulation in the Chinese medicine composition.

[0045] In the present invention, the traditional Chinese medicine composition comprises 40 to 45 parts of Hedyotis diffusa, preferably 42 to 44 parts, and more preferably 43 parts; the Hedyotis diffusa can play the role of clearing away heat and detoxifying, promoting blood circulation, reducing swelling and anti-cancer in the traditional Chinese medicine composition.

[0046] In the present invention, the traditional Chinese medicine composition includes 5 to 8 parts of coptis chinensis, preferably 6 to 7 parts, and more preferably 6.5 parts; the coptis chinensis can play the role of detoxifying jaundice and reducing inflammation in the traditional Chinese medicine composition.

[0047] In the present invention, the traditional Chinese medicine composition comprises 40 to 45 parts of Scutellaria barbata, preferably 42 to 44 parts, and more preferably 43 parts; the Scutellaria barbata in the traditional Chinese medicine composition can play an anti-cancer role in treating malignant sores and carbuncles.

[0048] In the present invention, the Chinese medicine composition comprises 60 to 70 parts of Smilax china, preferably 62 to 68 parts, more preferably 64 to 66 parts, and even more preferably 65 parts; the Smilax china can play an anti-cancer role in carbuncle, sore and ulcer in the Chinese medicine composition.

[0049] In the present invention, the traditional Chinese medicine composition comprises 175 to 185 parts of Humu root, preferably 176 to 184 parts, more preferably 178 to 182 parts, and even more preferably 180 parts; the Humu root can play the role of dispelling cold and relieving pain in malnutrition in the traditional Chinese medicine composition.

[0050] In the present invention, the traditional Chinese medicine composition includes 55 to 65 parts of Guanzhong, preferably 56 to 64 parts, more preferably 58 to 62 parts, and even more preferably 60 parts; the Guanzhong can play the role of clearing away heat, detoxifying and expelling parasites in the traditional Chinese medicine composition.

[0051] In the present invention, the traditional Chinese medicine composition includes 15 to 25 parts of thunder balls, preferably 16 to 24 parts, more preferably 18 to 22 parts, and even more preferably 20 parts; the thunder balls can play the role of expelling parasites and eliminating accumulation in the traditional Chinese medicine composition.

[0052] In the present invention, the Chinese medicine composition comprises 15 to 25 parts of Sophora flavescens, preferably 16 to 24 parts, more preferably 18 to 22 parts, and even more preferably 20 parts; the Sophora flavescens can play a role in clearing away heat and expelling parasites in the Chinese medicine composition.

[0053] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of hemp seeds, preferably 6 to 7 parts, and more preferably 6.5 parts; the hemp seeds in the traditional Chinese medicine composition can play a role in nourishing intestinal peristalsis.

[0054] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of Heichou, preferably 6 to 7 parts, and more preferably 6.5 parts; the Heichou can play an antiparasitic and laxative role in the traditional Chinese medicine composition.

[0055] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of costus root, preferably 6 to 7 parts, and more preferably 6.5 parts; the costus root in the traditional Chinese medicine composition can play a role in harmonizing the spleen, stomach, and large intestine qi.

[0056] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of louse, preferably 6 to 7 parts, and more preferably 6.5 parts; the louse can play the role of killing insects and eliminating accumulation in the traditional Chinese medicine composition.

[0057] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of betel nut, preferably 6 to 7 parts, and more preferably 6.5 parts; the betel nut can play the role of killing parasites, eliminating accumulation and relieving constipation in the traditional Chinese medicine composition.

[0058] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of black plum, preferably 6 to 7 parts, and more preferably 6.5 parts; the black plum can play the role of expelling parasites and astringing the intestines in the traditional Chinese medicine composition.

[0059] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of Hexagram Coconut Tree, preferably 6 to 7 parts, and more preferably 6.5 parts; the Hexagram Coconut Tree can play the role of clearing away heat, detoxifying and expelling parasites in the traditional Chinese medicine composition.

[0060] In the present invention, the traditional Chinese medicine composition comprises 5 to 8 parts of Tianmingjing, preferably 6 to 7 parts, and more preferably 6.5 parts; the Tianmingjing can stop bleeding, resolve blood stasis and kill parasites in the traditional Chinese medicine composition.

[0061] In the present invention, the Chinese medicine composition includes 5 to 8 parts of Evodia elata, preferably 6 to 7 parts, and more preferably 6.5 parts; the Evodia elata in the Chinese medicine composition can play a role in eliminating gastroenteritis and malnutrition.

[0062] In the present invention, the dosage form of the traditional Chinese medicine composition preferably includes granules and capsules.

[0063] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0064] The raw material components of the traditional Chinese medicine composition are dried, crushed and mixed respectively to obtain the traditional Chinese medicine composition.

[0065] In the present invention, the drying temperature is preferably 50-60°C, the drying time is preferably 24-48h, and the instrument used for the drying is preferably a hot air circulation dryer or a heat pump dryer; the humidity in the raw materials in the initial stage of the drying is relatively high, and dehumidification needs to be strengthened, and the temperature should be controlled at 50°C. In the later stage of the drying, the temperature should be gradually increased to 60°C to prevent moisture resorption; the dried medicinal materials have the characteristics of being easy to break and having no soft core; the preferred spreading thickness of the raw materials during the drying is set to ≤5cm, and they are placed in layers to avoid accumulation and maintain uniform airflow; after the pulverization, it is preferably filtered using a 100-130 mesh sieve, more preferably 110-120 mesh, and even more preferably 115 mesh.

[0066] The present invention also provides the use of the traditional Chinese medicine composition in preparing medicine for treating aplastic anemia.

[0067] Example 1

[0068] A Chinese medicine composition comprising the following raw material components in parts by weight:

[0069] 12 parts of bupleurum, 42 parts of murraya, 12 parts of codonopsis, 12 parts of broad beetles, 12 parts of cinnamon twigs, 12 parts of poria, 42 parts of coix seeds, 12 parts of apricot kernel, 42 parts of atractylodes, 12 parts of poria, 12 parts of dried tangerine peel, 60 parts of ginkgo, 20 parts of indigo, 12 parts of moutan bark, 42 parts of herba hedyotis diffusae, 6 parts of coptis chinensis, 42 parts of scutellaria barbata, 66 parts of smilax china, 180 parts of rhizoma humuli, 60 parts of cyperus rotundus, 20 parts of thunder balls, 20 parts of sophora flavescens, 6 parts of fructus hemp seeds, 6 parts of black ugly, 6 parts of costus root, 6 parts of scutellaria baicalensis, 6 parts of areca catechu, 6 parts of plum ebony root, 6 parts of hexagram, 6 parts of tianya, 6 parts of scutellaria baicalensis.

[0070] Example 2

[0071] A Chinese medicine composition comprising the following raw material components in parts by weight:

[0072] 10 parts of bupleurum, 40 parts of murraya, 10 parts of codonopsis, 10 parts of scutellaria, 10 parts of cinnamon twig, 10 parts of poria, 40 parts of coix seed, 10 parts of apricot kernel, 40 parts of atractylodes, 10 parts of poria, 10 parts of dried tangerine peel, 55 parts of ginkgo, 15 parts of indigo, 10 parts of moutan bark, 40 parts of herba hedyotis diffusae, 5 parts of coptis root, 40 parts of scutellaria barbata, 60 parts of smilax china, 175 parts of humus root, 55 parts of cyperus rotundus, 15 parts of thunder ball, 15 parts of sophora flavescens, 5 parts of fructus hemp, 5 parts of black ugly, 5 parts of costus root, 5 parts of scutellaria baicalensis, 5 parts of areca catechu, 5 parts of plum, 5 parts of hexagram, 5 parts of tianmingjing, 5 parts of scutellaria baicalensis.

[0073] Example 3

[0074] A Chinese medicine composition comprising the following raw material components in parts by weight:

[0075] 15 parts of bupleurum, 45 parts of murraya, 15 parts of codonopsis, 15 parts of scutellaria, 15 parts of cinnamon twig, 15 parts of poria, 45 parts of coix seed, 15 parts of apricot kernel, 45 parts of atractylodes, 15 parts of poria, 15 parts of dried tangerine peel, 65 parts of ginkgo, 25 parts of indigo, 15 parts of moutan bark, 45 parts of herba hedyotis diffusae, 8 parts of coptis root, 45 parts of scutellaria barbata, 70 parts of smilax china, 185 parts of rhizoma cyrtonemae, 65 parts of cyperus rotundus, 25 parts of thunder ball, 25 parts of sophora flavescens, 8 parts of fructus hemp, 8 parts of black ugly, 8 parts of costus root, 8 parts of scutellaria baicalensis, 8 parts of areca catechu, 8 parts of plum, 8 parts of hexagram, 8 parts of tianya, 8 parts of scutellaria baicalensis.

[0076] Example 4

[0077] A method for preparing the Chinese medicine composition comprises the following steps:

[0078] Under sterile and dust-free conditions, the raw material components of the traditional Chinese medicine composition in Example 1 were cleaned separately, dried at 55° C. for 24 h, crushed, and passed through a 120-mesh sieve. The sieved raw material components were mixed to obtain the traditional Chinese medicine composition.

[0079] Example 5

[0080] A method for preparing the Chinese medicine composition comprises the following steps:

[0081] Under sterile and dust-free conditions, the raw material components of the traditional Chinese medicine composition in Example 2 were cleaned separately, dried at 50° C. for 48 h, crushed, and passed through a 100-mesh sieve. The sieved raw material components were mixed to obtain the traditional Chinese medicine composition.

[0082] Example 6

[0083] A method for preparing the Chinese medicine composition comprises the following steps:

[0084] Under sterile and dust-free conditions, the raw material components of the traditional Chinese medicine composition in Example 3 were cleaned separately, dried at 60° C. for 30 h, crushed, and passed through a 130-mesh sieve. The sieved raw material components were mixed to obtain the traditional Chinese medicine composition.

[0085] Test Example 1

[0086] A 19-year-old female patient diagnosed with aplastic anemia was selected. At the same time, patients with severe infection, other complications and malignant tumors, dependence on taking western medicine and blood transfusion, and low bone marrow hematopoietic function were excluded.

[0087] The Chinese medicine composition prepared in Example 4 was sterilized and packaged into capsules, which were then administered to the patient at a dose of 6 g per day, divided into two doses, for a course of 3 months.

[0088] After 3 months of treatment, the patient's fatigue and bleeding tendency were alleviated, and the frequency of infection decreased. Among them, the patient's hemoglobin Hb index increased from 40g / L to 105g / L; the platelet PLT index increased from <10×10 9 / L increased to 30×10 9 / L; WBC count from 3×10 9 / L increased to 7.5×10 9 / L.

[0089] Test Example 2

[0090] 1. Research subjects

[0091] Thirty patients diagnosed with chronic aplastic anemia were randomly divided into a treatment group (n=15) and a control group (n=15). There was no statistical difference between the two groups in age, gender, disease duration, and baseline blood count (Hb, WBC, PLT) (P>0.05).

[0092] Administration: The Chinese medicine composition prepared in Example 4 was sterilized and encapsulated into capsules, named Xuefukang Capsules; the capsules were administered to the patient at a dose of 6 g per day, divided into 2 doses, for a course of 3 months.

[0093] 2. Treatment Methods

[0094] Treatment group: Xuefukang capsule;

[0095] Control group: conventional western medicine (cyclosporine A 3 mg / kg / d + stanozolol 6 mg / d).

[0096] Treatment course: Continuous treatment for 3 months, monthly review of blood routine, reticulocyte count and liver and kidney function, record of bleeding, infection events and blood transfusion frequency.

[0097] 3. Standards for basic cure and marked effect

[0098] 3.1 Basically cured:

[0099] Clinical symptoms: Anemia, bleeding, and infection symptoms completely disappear;

[0100] Blood picture recovery: hemoglobin (Hb) ≥100g / L (male) or ≥90g / L (female), platelet (PLT) ≥100×10 9 / L, white blood cells (WBC) ≥4.0×10 9 / L, and maintained for more than 3 months;

[0101] Transfusion independence: free from transfusion dependence for ≥1 year.

[0102] 3.2 Significant effect:

[0103] Improved blood count: Hemoglobin increased by ≥30 g / L, platelets or white blood cells improved to a certain extent (such as PLT increased by ≥50% or absolute value ≥30×10 9 / L);

[0104] Symptom relief: reduced bleeding, reduced frequency of infections, and a ≥50% reduction in transfusion requirements.

[0105] 4. Experimental Results

[0106] 4.1 Improvement of blood indicators

[0107]

[0108] Note: (“*” indicates P<0.05 for comparison before and after treatment within the same group, “△” indicates P<0.05 for comparison after treatment between groups).

[0109] 4.2 Clinical efficacy

[0110] The total effective rate (basic cure + marked effect) in the treatment group was 96.7%, significantly higher than the 63.3% in the control group (P < 0.05). Fatigue, bleeding, and infection were all essentially cured or markedly effective in the treatment group. The blood transfusion dependency rate dropped from 100% in the treatment group to 3.2% and to 40.0% in the control group (P < 0.05).

[0111] 4.3 Security

[0112] There was no significant difference in the incidence of abnormal liver and kidney function between the two groups (5.0% in the treatment group vs 13.3% in the control group, P>0.05).

[0113] 5. Conclusion

[0114] From this test example, we can see that:

[0115] (1) The Chinese medicine composition (Xuefukang) provided by the present invention can significantly improve the hematopoietic function of patients with aplastic anemia, and its therapeutic effect is better than that of simple Western medicine treatment.

[0116] (2) This prescription strengthens the spleen and stomach and promotes intestinal motility, clearing toxins and parasites from the intestines and restoring the digestive and absorptive functions of the intestines. It fundamentally reverses the pathogenesis of aplastic anemia, eliminates blood transfusion dependence, and is safe, ultimately achieving the goal of recovery.

[0117] (3) The preparation method provided by the present invention is simple and suitable for clinical promotion and use.

[0118] As can be seen from the above embodiments, the present invention provides a traditional Chinese medicine composition, a preparation method and an application thereof, wherein the traditional Chinese medicine composition can remove intestinal waste, toxins and parasites, and treat both the symptoms and the root causes, thereby restoring the absorption and transportation functions of the small intestine and spleen to normal, and then promoting the restoration of the marrow-forming function of the small intestine and spleen to normal, thereby achieving the purpose of bone marrow and blood regeneration.

[0119] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition, characterized in that The raw material components include the following parts by weight: 10-15 parts of Bupleurum, 40-45 parts of Murraya Osmanthus, 10-15 parts of Codonopsis pilosula, 10-15 parts of Allium macrostemon, 10-15 parts of Cinnamon twig, 10-15 parts of Poria, 40-45 parts of Coix seeds, 10-15 parts of Apricot kernel, 40-45 parts of Atractylodes macrocephala, 10-15 parts of Poria, 10-15 parts of Tangerine peel, 55-65 parts of Ginkgo, 15-25 parts of Indigo naturalis, 10-15 parts of Cortex Moutan, 40- 45 parts, 5-8 parts of Coptis chinensis, 40-45 parts of Scutellaria barbata, 60-70 parts of Smilax china, 175-185 parts of Humu root, 55-65 parts of Cyperus rotundus, 15-25 parts of Thunder Ball, 15-25 parts of Sophora flavescens, 5-8 parts of Cannabis sativa seeds, 5-8 parts of Heichou, 5-8 parts of Costus root, 5-8 parts of Heshi, 5-8 parts of Areca catechu, 5-8 parts of Plum, 5-8 parts of Hexagram glutinosa, 5-8 parts of Tianmingjing, and 5-8 parts of Evodia rutaecarpa.

2. The Chinese medicine composition according to claim 1, characterized in that The raw material components include the following parts by weight: 12-14 parts of Bupleurum, 42-44 parts of Murraya Osmanthus, 12-14 parts of Codonopsis pilosula, 12-14 parts of Allium macrostemon, 12-14 parts of Cinnamon twig, 12-14 parts of Poria, 42-44 parts of Coix seeds, 12-14 parts of Apricot kernel, 42-44 parts of Atractylodes macrocephala, 12-14 parts of Poria, 12-14 parts of Tangerine peel, 56-64 parts of Ginkgo, 16-24 parts of Indigo, 12-14 parts of Cortex Moutan, 42-14 parts of Hedyotis diffusa. 44 parts, 6-7 parts of Coptis chinensis, 42-44 parts of Scutellaria barbata, 62-68 parts of Smilax china, 176-184 parts of Humu root, 56-64 parts of Cyperus rotundus, 16-24 parts of Thunder Ball, 16-24 parts of Sophora flavescens, 6-7 parts of Cannabis sativa seeds, 6-7 parts of Heichou, 6-7 parts of Costus root, 6-7 parts of Heshi, 6-7 parts of Areca catechu, 6-7 parts of Plum, 6-7 parts of Hexagram glutinosa, 6-7 parts of Tianmingjing, and 6-7 parts of Evodia rutaecarpa.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that The dosage forms of the traditional Chinese medicine composition include granules and capsules.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: The raw material components of the traditional Chinese medicine composition according to any one of claims 1 to 3 are dried, crushed and mixed to obtain the traditional Chinese medicine composition.

5. The method according to claim 4, characterized in that The drying temperature is 50-60° C., and the drying time is 24-48 hours.

6. The method according to claim 4, characterized in that After the pulverization, the product is filtered using a 100-130 mesh sieve.

7. Use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating aplastic anemia.

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