Electric ablation endoscopic probe, method, equipment and medium based on OCT (Optical Coherence Tomography) guidance

Abstract

The invention relates to the technical field of medical instruments, in particular to an electric ablation endoscopic probe based on OCT guidance, a method, equipment and a medium, the electric ablation endoscopic probe comprises an OCT monitoring module, an electric ablation electrode array and a temperature detection assembly, and the OCT monitoring module is used for outputting a scanning light beam; the electric ablation electrode array is used for performing electric ablation on the target to-be-ablated area; the temperature detection assembly is used for obtaining the temperature value of the target to-be-ablated area in the electric ablation process so as to maintain the current electric ablation parameters of the electric ablation electrode array according to the temperature value of the target to-be-ablated area, or adjust the current electric ablation parameters of the electric ablation electrode array according to the temperature value of the target to-be-ablated area. Therefore, the problems of diagnosis and treatment separation and large ablation blind area in the background technology are solved, accurate focus positioning and energy controllable ablation are achieved, and high safety and clinical applicability are achieved.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to an OCT-guided electroablation endoscopic probe, method, device, and medium. Background Art

[0002] In recent years, the incidence of early gastrointestinal cancer has been on the rise. Early, accurate diagnosis and effective treatment are crucial to improving patient survival and quality of life. Currently, endoscopic examination is the main method for diagnosing early gastrointestinal cancer, but conventional endoscopy has limited ability to identify early lesions and is prone to missed diagnosis. Although optical coherence tomography (OCT) technology can provide high-resolution tomographic imaging, existing OCT probes are only used for diagnosis and require additional equipment for biopsy or treatment, making the operation complicated and inefficient. Although electrical ablation is an effective treatment for early gastrointestinal cancer, during the ablation process, accurately judging the ablation range and depth to avoid excessive damage to surrounding normal tissues remains a clinical challenge. Introducing OCT technology into gastrointestinal endoscopy is expected to improve diagnostic accuracy, but there is currently a lack of a real-time OCT-guided ablation energy dynamic regulation mechanism, making it difficult to balance treatment effect and safety. In addition, the separation of diagnosis and treatment leads to multiple operations, increasing patient risks.

[0003] In the related technologies, such as patent CN202321733628.3 "A composite radiofrequency ablation catheter", discloses a radiofrequency ablation endoscopic probe, which can cool the tissue around the working end to avoid carbonization of the lesion tissue, but lacks OCT imaging monitoring and monitoring of the OCT imaging function. It relies on traditional endoscopic white light images to locate the lesion, and has low accuracy; patent CN200410019746.3 "Medical endoscopic micro-ultrasound-OCT probe" discloses a micro-ultrasound-OCT endoscopic probe, which can not only directly observe the lesion morphology of the mucosal surface through an endoscope, but also perform ultrasound scanning and OCT imaging to obtain the histological characteristics of each layer of the digestive organ wall. , which expands the endoscopic diagnostic range and improves the diagnostic capability. However, the system does not integrate temperature or blood flow sensors, relies on the grayscale change of OCT images to determine the ablation end point, lacks multimodal data verification, and has no ablation system, only realizing the scanning function; Patent CN202211249484.4 "Optical coherence tomography-guided laser minimally invasive diagnosis and treatment endoscopic probe" discloses a laser ablation system based on OCT guidance, which combines OCT and laser ablation, and through the design structure, it shares the same optical path, which can realize integrated diagnosis and treatment, with the advantages of simple operation and less damage to patients. However, the system uses laser instead of electric ablation, which is more suitable for superficial lesions and has limited penetration into deep tissues, which urgently needs to be solved. Summary of the Invention

[0004] The present application provides an OCT-guided electroablation endoscopic probe, method, device and medium to solve the problems of separation of diagnosis and treatment and large ablation blind spots in the background technology, achieve precise positioning of lesions and energy-controlled ablation, and have high safety and clinical applicability.

[0005] The first embodiment of the present application provides an OCT-guided electroablation endoscopic probe, comprising:

[0006] An OCT monitoring module is configured to output a scanning beam, scan and image the target tissue, obtain a microstructure image of the target tissue, and determine a target area to be ablated based on the microstructure image of the target tissue;

[0007] An electrical ablation electrode array is used to perform electrical ablation on the target area to be ablated;

[0008] The temperature detection component is used to obtain the temperature value of the target area to be ablated during the electroablation process, so as to maintain the current electroablation parameters of the electroablation electrode array according to the temperature value of the target area to be ablated, or to adjust the current electroablation parameters of the electroablation electrode array.

[0009] According to one embodiment of the present application, the OCT monitoring module includes:

[0010] OCT imaging optical fiber, used to output scanning beam;

[0011] a first reflecting mirror, configured to transmit the output scanning light beam to a target tissue;

[0012] a second reflecting mirror, used for reflecting the output scanning light beam;

[0013] The MEMS galvanometer is used to reflect the scanning light beam and achieve scanning within a preset angle range.

[0014] According to one embodiment of the present application, the shape and size of the electroablation electrode array are both adjustable, the electroablation electrode array is connected to an external electroablation generator, and the electroablation electrode array is further used to:

[0015] The target area to be ablated is electrically ablated according to the adjusted new electrical ablation parameters.

[0016] According to one embodiment of the present application, the first reflector is an ellipsoidal reflector.

[0017] According to one embodiment of the present application, the second reflector is a plane reflector.

[0018] According to one embodiment of the present application, the OCT-guided electroablation endoscopic probe further includes:

[0019] A data processing component is used to process the microstructure image of the target tissue, the current electrical ablation parameters and the temperature value of the target area to be ablated.

[0020] According to one embodiment of the present application, the OCT-guided electroablation endoscopic probe further includes:

[0021] The early warning alarm module is used to issue an early warning alarm when the temperature value of the target area to be ablated is greater than a preset temperature value.

[0022] According to the OCT-guided electroablation endoscopic probe provided in the embodiment of the present application, the target tissue is scanned and imaged to obtain a microstructural image of the target tissue, and the target area to be ablated is determined. The target area to be ablated is electroablated, and the current electroablation parameters of the electroablation electrode array are adjusted based on the temperature value of the target area to be ablated. The target area to be ablated is electroablated based on the adjusted new electroablation parameters. This solves the problems of separation of diagnosis and treatment and large ablation blind spots in the background technology, achieves precise positioning of lesions and energy-controlled ablation, and has high safety and clinical applicability.

[0023] A second embodiment of the present application provides an OCT-guided electroablation endoscopic method, wherein the method uses an OCT-guided electroablation endoscopic probe and comprises the following steps:

[0024] Scanning and imaging the target tissue using the OCT monitoring module to obtain a microstructure image of the target tissue;

[0025] Determining a target area to be ablated according to the microstructure image of the target tissue, performing electroablation on the target area to be ablated using the electroablation electrode array, and obtaining a temperature value of the target area to be ablated during the electroablation process using the temperature detection component;

[0026] The current electroablation parameters of the electroablation electrode array are adjusted based on the temperature value of the target area to be ablated, and the target area to be ablated is electroablated based on the adjusted new electroablation parameters.

[0027] According to one embodiment of the present application, adjusting the current electroablation parameters of the electroablation electrode array based on the temperature value of the target area to be ablated includes:

[0028] Determining whether the temperature of the target area to be ablated is greater than a preset temperature value;

[0029] If the temperature value of the target area to be ablated is greater than the preset temperature value, the electroablation operation on the target area to be ablated is suspended, or the current electroablation parameters of the electroablation electrode array are adjusted based on a preset parameter adjustment strategy.

[0030] According to one embodiment of the present application, after determining whether the temperature value of the target area to be ablated is greater than a preset temperature value, the method further includes:

[0031] If the temperature value of the target area to be ablated is within a preset temperature range, maintaining the current electroablation parameters based on the electroablation electrode array to perform electroablation on the target area to be ablated;

[0032] Wherein, the upper limit value of the preset temperature range is less than or equal to the preset temperature value.

[0033] According to the OCT-guided electroablation endoscopic method provided in the embodiment of the present application, the target tissue is scanned and imaged to obtain a microstructural image of the target tissue, and the target area to be ablated is determined. The target area to be ablated is electroablated, and the current electroablation parameters of the electroablation electrode array are adjusted based on the temperature value of the target area to be ablated. The target area to be ablated is electroablated based on the adjusted new electroablation parameters. This solves the problems of separation of diagnosis and treatment and large ablation blind spots in the background technology, achieves precise positioning of lesions and energy-controlled ablation, and has high safety and clinical applicability.

[0034] The third aspect of the present application provides an electronic device, comprising: a memory, a processor, and a computer program stored on the memory and executable on the processor, wherein the processor executes the program to implement the OCT-guided electroablation endoscopy method as described in the above embodiment.

[0035] A fourth aspect of the present application provides a computer-readable storage medium storing computer instructions for enabling the computer to execute the OCT-guided electroablation endoscopy method as described in the above embodiments.

[0036] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0038] Figure 1 Schematic diagram of the structure of an OCT-guided electroablation endoscopic probe according to an embodiment of the present application;

[0039] Figure 2 Schematic diagram of the optical path principle of an OCT monitoring module according to one embodiment of the present application;

[0040] Figure 3 is a schematic diagram of an electroablation electrode array according to one embodiment of the present application;

[0041] Figure 4 1 is a structural block diagram of an OCT-guided electroablation endoscopic probe according to an embodiment of the present application;

[0042] Figure 5 This is a flow chart of an OCT-guided electroablation endoscopic method according to an embodiment of the present application;

[0043] Figure 6 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application.

[0044] Figure numerals: 101 - OCT monitoring module, 102 - electroablation electrode array, 103 - temperature detection component, 104 - data processing component, 1011 - OCT imaging optical fiber, 1012 - first reflector, 1013 - second reflector, 1014 - MEMS galvanometer; 601 - memory, 602 - processor, 603 - communication interface. DETAILED DESCRIPTION

[0045] The following describes in detail embodiments of the present application, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present application, and should not be construed as limiting the present application.

[0046] The following describes the OCT-guided electroablation endoscopic probe, method, device, and medium according to the embodiments of the present application with reference to the accompanying drawings.

[0047] Specifically, if Figure 1As shown, the OCT-guided electroablation endoscopic probe of an embodiment of the present application includes an elongated probe body, which integrates an OCT monitoring module 101, an electroablation electrode array 102, a temperature detection component 103, and a data processing component 104. The OCT monitoring module 101 includes an OCT imaging fiber 1011, a first reflector 1012, a second reflector 1013, and a MEMS (Micro-Electro-Mechanical Systems) galvanometer 1014. By integrating the OCT monitoring module and the electroablation electrode array in a miniaturized probe, seamless switching between diagnostic and therapeutic functions is achieved. In addition, the temperature detection component 103 (thermocouple or fiber optic temperature measurement) synchronizes data acquisition with the OCT image, forming a closed-loop feedback loop.

[0048] Optionally, the first reflector 1012 may be an ellipsoidal reflector, the second reflector 1013 may be a plane reflector, and the temperature detection component 103 may be a temperature sensor, which is not specifically limited here.

[0049] Furthermore, the OCT imaging fiber 1011 is used to output a scanning beam; the first reflector 1012 is used to transmit the output scanning beam to the target tissue; the second reflector 1013 is used to reflect the output scanning beam; and the MEMS galvanometer 1014 is used to reflect the scanning beam, enabling scanning within a preset angle range. The electroablation electrode array 102 is used to perform electroablation; the temperature detection component 103 is used to monitor temperature; and the data processing terminal component 104 is used to transmit image data, control signals, and power.

[0050] The target tissue refers to a specific pathological tissue region of the human body that is examined or treated by optical coherence tomography. For example, the target tissue in the embodiment of the present application may be the digestive tract tissue.

[0051] Furthermore, before the electrical ablation treatment, the OCT monitoring module 101 is used to obtain a high-resolution microscopic structural image of the early cancer lesion of the target tissue. Figure 2 As shown, the OCT monitoring module 101 of the embodiment of the present application adopts the principle of fiber optic interferometry, including a light source, a fiber optic coupler, a reference arm and a sample arm ( Figure 2The diagram only shows the imaging fiber 1011 of the OCT monitoring module 101, i.e., components such as the reference arm and fiber coupler are omitted. Scanning light enters the probe through the imaging fiber 1011 of the OCT monitoring module 101. The low-coherence light emitted by the light source is split into two beams by the fiber coupler. One beam enters the reference arm, and the other beam is transmitted to the front end of the sample arm through the imaging fiber 1011 of the OCT monitoring module 101. It is then reflected by the first reflector 1012, the second reflector 1013, and then reflected by the MEMS galvanometer 1014 onto the target tissue surface. The tissue-reflected light and the reference arm light interfere at the fiber coupler. The interference signal is converted into an electrical signal by the detector, and then the signal processing module generates an OCT image.

[0052] Furthermore, in order to achieve scanning of different parts of human organs (such as the wall of the digestive tract), the scanning light output from the front end of the imaging optical fiber 1011 of the OCT monitoring module 101 can ultimately be rotated or swung for scanning imaging through the MEMS galvanometer 1014, and can scan within a certain angle range to obtain comprehensive tissue image information, that is, the microscopic structure image of the target tissue.

[0053] Among them, the light outlet of the imaging optical fiber 1011 of the OCT monitoring module 101 is located at the focus of the first reflector. According to the geometric knowledge of the ellipsoid, the light beam will be focused at another focus, that is, the location of the lesion tissue, thereby completing the OCT real-time monitoring work.

[0054] For example, in the embodiment of the present application, a laser light source with a central wavelength of 1310 nm can be selected as the imaging light in the OCT monitoring module 101. It has a high output power, a wide spectral bandwidth and good penetration in human tissue, which can ensure the resolution and sensitivity of OCT imaging. The principle of using an ellipsoidal reflector for reflection and final convergence is that, from the perspective of geometric optics, due to the special properties of the ellipse, all light emitted from focus 1 can be propagated to focus 2 along a path with equal optical path after being reflected by the ellipsoidal surface, so that the light converges on another focus 2. Using a plane mirror to reflect the light beam can reduce the size of the probe and control the direction of the light beam. The MEMS galvanometer 1014 is driven by a high-precision motor, which can achieve fast two-dimensional scanning, expand the scanning range, and obtain OCT image data of the target tissue. In short, in the imaging light path, the imaging light output by the imaging optical fiber 1011 passes through the ellipsoidal reflector, the plane reflector and the MEMS galvanometer 1014 in sequence to ensure that it is accurately focused on the lesion tissue.

[0055] Therefore, through the OCT monitoring module 101, high-resolution microstructure images of target tissue lesions can be obtained before electrical ablation treatment, and the boundaries, depth and infiltration range of the lesions can be accurately determined, providing a basis for formulating personalized electrical ablation treatment plans.

[0056] Furthermore, after finding the lesion tissue, electrical ablation is performed through the electrical ablation electrode array 102 in combination with real-time monitoring of the OCT image and temperature detection component 103. During the ablation process, the OCT image data, ablation conditions and temperature conditions will be output through the data processing component 104 of the probe to facilitate data processing by technicians. The technicians can adjust the ablation parameters and positions in time according to the OCT images and temperature conditions to ensure that the ablation range covers the lesion tissue and avoids damage to the surrounding normal tissue.

[0057] Optionally, platinum-iridium alloy wire can be used as the electroablation electrode material in this embodiment of the present application, as it has excellent conductivity, biocompatibility, and corrosion resistance. The platinum-iridium alloy wire is processed into a needle-shaped electrode with a tip diameter of 0.1 mm to achieve precise electroablation treatment. The electrode length is determined according to the design requirements of the endoscopic probe to ensure that the electroablation energy is concentrated on the lesion site.

[0058] For example, the electroablation electrode of the embodiment of the present application can be arranged near the probe window and be designed with adjustable shape and size to accommodate early gastrointestinal cancer lesions of different sizes and shapes.

[0059] Optionally, the electroablation electrode array 102 of the embodiment of the present application can be as follows: Figure 3 As shown, it should be noted that Figure 3 The electroablation electrode array 102 shown is only exemplary. The electroablation electrode array 102 of the embodiment of the present application is customizable and supports monopolar / bipolar mode switching. The electrode density and arrangement (annular / linear) can be adjusted according to the range of the lesion and are not specifically limited here.

[0060] Optionally, the temperature detection component 103 of the embodiment of the present application is located adjacent to the electrical ablation electrode and may use a micro-thermistor or thermocouple to convert the temperature signal into an electrical signal and transmit it to an external device.

[0061] Specifically, the high resolution of OCT (≤10μm) is used to identify the boundaries of mucosal lesions (such as areas of dysplasia), and AI algorithms (such as CNN segmentation models) can accurately determine the boundaries, depth, and infiltration range of lesions, thereby identifying the lesion area in the target tissue and automatically marking the area that requires electrical ablation, that is, the target area to be ablated.

[0062] Furthermore, the electroablation electrode is connected to an external electroablation generator, and precise ablation of the diseased tissue can be achieved by controlling the output parameters of the electroablation generator, such as current intensity, frequency, and pulse width.

[0063] Furthermore, a miniature thermistor is installed near the electroablation electrode as a temperature detection component 103, and the temperature detection component 103 is used to monitor the temperature changes of the target ablation area during the electroablation process in real time. The temperature detection component 103 is connected to the signal transmission line inside the probe to transmit the temperature signal to the external control system.

[0064] Furthermore, the current electroablation parameters of the electroablation electrode array 102 are adjusted based on the temperature of the target area to be ablated obtained by the temperature detection component 103, and the target area to be ablated is electroablated based on the adjusted new electroablation parameters. If the temperature value of the target area to be ablated is greater than a preset temperature value, the electroablation operation on the target area to be ablated is suspended, or the current electroablation parameters of the electroablation electrode array 102 are adjusted based on a preset parameter adjustment strategy.

[0065] Furthermore, the OCT-guided electroablation endoscope probe further includes: an early warning alarm module ( Figure 1 (not shown in the figure), the early warning alarm module is used to issue an early warning alarm when the temperature value of the target area to be ablated is greater than a preset temperature value.

[0066] The preset temperature value may be a safety temperature threshold value pre-set by those skilled in the art, and is not specifically limited here.

[0067] Specifically, if the temperature value of the target area to be ablated is greater than the preset temperature value, it means that the temperature of the target area to be ablated exceeds the safety threshold. At this time, the control warning alarm module issues a high temperature warning alarm reminder, and controls the system to suspend ablation, or the control system automatically adjusts the electric ablation parameters, thereby adjusting the energy output of electric ablation to avoid excessive thermal damage to the tissue.

[0068] For example, the embodiment of the present application can adjust the electrical ablation power (5-50W) and pulse interval in real time according to the coagulation depth (such as changes in the reflectivity of the submucosal layer) and temperature data displayed by OCT to avoid excessive ablation (such as perforation) or residual lesions.

[0069] In addition, if the temperature value of the target area to be ablated is within the preset temperature range, it means that the temperature value of the target area to be ablated is within a safe range, which can effectively kill diseased cells while avoiding excessive thermal damage to normal tissues. Therefore, there is no need to adjust the current electroablation parameters. The control system will maintain the current electroablation parameters unchanged, that is, the electroablation electrode array 102 will continue to ablate with the current current intensity, frequency, pulse width and other parameters.

[0070] Therefore, during the electrical ablation process, by combining OCT images and real-time monitoring of temperature sensors, changes in the ablation area can be intuitively observed, and ablation parameters can be adjusted in a timely manner to ensure that the ablation range covers the diseased tissue while avoiding unnecessary damage to surrounding normal tissues, thereby improving the safety and effectiveness of treatment.

[0071] In addition, the embodiments of the present application can analyze OCT image features (such as grayscale value, vascular density, and layered structure damage) by training a deep learning model, predict the optimal ablation parameter combination, and verify whether the conditions for ending electrical ablation are met through multi-sensor collaboration.

[0072] For example, the temperature of the target area to be ablated obtained by the temperature sensor is in a preset temperature range, such as 70-90°C, and the blood flow signal disappears according to the blood flow sensor data, and the OCT coagulation zone is formed according to the OCT monitoring module 101. If the above three verifications are all met, it is determined that the end conditions of electroablation are met and electroablation is stopped.

[0073] Furthermore, the data processing component 104 of the embodiment of the present application is used to perform data processing on the microstructure image of the target tissue, the current electrical ablation parameters, and the temperature value of the target area to be ablated.

[0074] Specifically, the probe's back-end interfaces include image data transmission, ablation control, and power supply. Data control and acquisition for OCT scan images, ablation electrodes, and temperature sensors are all exported to the data processing end through the probe's peripherals for external processing.

[0075] Furthermore, the image data transmission interface is used to transmit image data generated by the OCT monitoring module 101 to an external image processing workstation for image display and analysis. The electroablation control interface is used to receive control signals from an external console to adjust the operating parameters of the electroablation electrodes. The power supply interface is used to provide a stable power supply to the various modules within the endoscopic probe.

[0076] In order to facilitate those skilled in the art to more clearly and intuitively understand the OCT-guided electroablation endoscopic probe of the embodiment of the present application, the following is combined with Figure 4 Provide detailed explanation.

[0077] Specifically, if Figure 4 As shown, light from a low-coherence light source is transmitted via an imaging fiber to an ellipsoidal reflector, then reflected by a plane mirror and, finally, by a MEMS galvanometer mirror onto the surface of the digestive tract tissue. The tissue-reflected light interferes with the reference arm light at the fiber coupler, generating an OCT image for precise lesion localization. The electroablation electrode array is connected to an external electroablation generator, and a temperature monitoring component monitors the temperature of the ablation area in real time.

[0078] When an OCT scan detects a lesion, the system quantifies the lesion information. During the ablation process, the system monitors the temperature in real time. If the temperature exceeds the safety threshold, ablation will be automatically suspended. If the temperature is normal, ablation will continue until the lesion is completely eliminated. Finally, the ablation results will be output in real time using the data processing component.

[0079] It should be noted that the front end of the OCT-guided electroablation endoscope probe in the embodiment of the present application is detachable and can be adapted to different endoscope types (gastroscope, colonoscope) and lesion morphologies (annular / focal lesions).

[0080] Therefore, by designing an endoscopic probe that integrates OCT monitoring, electroablation and temperature monitoring functions, the operation process is simplified, the pain of patients during examination and treatment is reduced, and clinical work efficiency is improved. In addition, the modular probe of this application is compatible with a variety of endoscopic platforms and has strong promotion potential.

[0081] The following describes an OCT-guided electroablation endoscopic method applied to the above-mentioned OCT-guided electroablation endoscopic probe.

[0082] Specifically, Figure 5 A schematic flow chart of an OCT-guided electroablation endoscopic method provided in an embodiment of the present application.

[0083] like Figure 5 As shown, the OCT-guided electroablation endoscopic method includes the following steps:

[0084] In step S501 , the OCT monitoring module 101 is used to scan and image the target tissue to obtain a microstructure image of the target tissue.

[0085] In step S502 , the target area to be ablated is determined based on the microstructure image of the target tissue, the target area to be ablated is electrically ablated using the electroablation electrode array 102 , and the temperature detection component 103 is used to obtain the temperature value of the target area to be ablated during the electroablation process.

[0086] In step S503, the current electroablation parameters of the electroablation electrode array 102 are adjusted based on the temperature value of the target area to be ablated, and the target area to be ablated is electroablated based on the adjusted new electroablation parameters.

[0087] Furthermore, in some embodiments, the current electroablation parameters of the electroablation electrode array 102 are adjusted based on the temperature value of the target area to be ablated, including: determining whether the temperature value of the target area to be ablated is greater than a preset temperature value; if the temperature value of the target area to be ablated is greater than the preset temperature value, suspending the electroablation operation on the target area to be ablated, or adjusting the current electroablation parameters of the electroablation electrode array 102 based on a preset parameter adjustment strategy.

[0088] Furthermore, in some embodiments, after determining whether the temperature value of the target area to be ablated is greater than the preset temperature value, it also includes: if the temperature value of the target area to be ablated is within the preset temperature range, then maintaining the current electroablation parameters based on the electroablation electrode array 102 to perform electroablation on the target area to be ablated; wherein the upper limit value of the preset temperature range is less than or equal to the preset temperature value.

[0089] Furthermore, in some embodiments, the OCT-guided electroablation endoscopic method further includes: utilizing the data processing component 104 of the electroablation endoscopic probe to perform data processing on the microstructure image of the target tissue, current electroablation parameters, and temperature values of the target area to be ablated.

[0090] In order to help those skilled in the art to understand the OCT-guided electroablation endoscopic method proposed in this application more clearly and intuitively, it is described in detail below in conjunction with specific examples of preclinical experiments.

[0091] Specifically, the experimental animals were first prepared. Five healthy miniature pigs were selected as experimental animals and a comprehensive health check was performed before the experiment to ensure that the animals were in good physical condition. The animals were deprived of food and water for 12 hours before the experiment to reduce the impact of digestive tract contents on the experiment.

[0092] Secondly, simulated lesions were created. Endoscopically, a specific cell suspension was injected into the stomach and esophagus of miniature pigs to induce the formation of lesions resembling early-stage digestive tract cancer. The cell suspension, composed of a mixture of human cancer cell lines and extracellular matrix, simulated the growth and invasion of tumor cells. Seven days after lesion formation, a preliminary assessment was performed to ensure that the lesion size and morphology met experimental requirements.

[0093] Next, perform endoscopic probe detection and treatment. Insert the prepared OCT-guided electroablation endoscopic probe into the digestive tract of the miniature pig through the mouth, and image the simulated lesion site through the OCT monitoring module. Observe the OCT image to determine the boundary, depth, and morphological characteristics of the lesion, providing a basis for subsequent electroablation treatment. According to the OCT monitoring results, adjust the position and energy parameters of the electroablation electrode, and perform electroablation treatment on the simulated lesion. During the treatment, monitor the data of the temperature sensor in real time to ensure that the tissue temperature is within a safe range. After the treatment, use the OCT monitoring module again to observe the lesion site, evaluate the effect of electroablation treatment, and determine whether the lesion tissue has been completely ablated.

[0094] Finally, histopathological analysis was performed. On the first and seventh days after electroablation treatment, the experimental animals were euthanized, and digestive tract tissue samples, including the lesion site, were removed. The samples were fixed, sectioned, and stained. Histopathological analysis was performed to observe the ablation of the lesioned tissue, the extent of damage to surrounding tissue, and the inflammatory response. These results were compared with OCT monitoring results and data from the electroablation treatment process to evaluate the performance of the endoscopic probe and the therapeutic effect.

[0095] Therefore, according to the OCT-guided electroablation endoscopic method of the embodiment of the present application, through the collaboration of the OCT monitoring module, multimodal sensor and intelligent feedback system, it is possible to use OCT technology to accurately detect and locate early gastrointestinal cancer lesions before electroablation treatment, and monitor the ablation range and depth in real time during the ablation process, thereby improving the treatment effect and reducing complications.

[0096] It should be noted that the aforementioned explanation of the embodiment of the OCT-guided electroablation endoscopic probe is also applicable to the OCT-guided electroablation endoscopic method of this embodiment, and will not be repeated here.

[0097] According to the OCT-guided electroablation endoscopic method proposed in the embodiment of the present application, the target tissue is scanned and imaged to obtain a microstructural image of the target tissue, and the target area to be ablated is determined. The target area to be ablated is electroablated, and the current electroablation parameters of the electroablation electrode array are adjusted based on the temperature value of the target area to be ablated. The target area to be ablated is electroablated based on the adjusted new electroablation parameters. This solves the problems of separation of diagnosis and treatment and large ablation blind spots in the background technology, achieves precise positioning of lesions and energy-controlled ablation, and has high safety and clinical applicability.

[0098] Figure 6 This is a schematic diagram of the structure of an electronic device provided in an embodiment of the present application. The electronic device may include:

[0099] A memory 601 , a processor 602 , and a computer program stored in the memory 601 and executable on the processor 602 .

[0100] When the processor 602 executes the program, the OCT-guided electroablation endoscopic method provided in the above embodiment is implemented.

[0101] Furthermore, the electronic device further includes:

[0102] The communication interface 603 is used for communication between the memory 601 and the processor 602 .

[0103] The memory 601 is used to store computer programs that can be run on the processor 602 .

[0104] The memory 601 may include a high-speed RAM memory, and may also include a non-volatile memory (non-volatile memory), such as at least one disk memory.

[0105] If the memory 601, processor 602, and communication interface 603 are implemented independently, the communication interface 603, memory 601, and processor 602 can be interconnected via a bus and communicate with each other. The bus can be an Industry Standard Architecture (ISA) bus, a Peripheral Component Interconnect (PCI) bus, or an Extended Industry Standard Architecture (EISA) bus. The bus can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 6 Only one thick line is used in the diagram, but this does not mean that there is only one bus or one type of bus.

[0106] Optionally, in a specific implementation, if the memory 601, the processor 602 and the communication interface 603 are integrated on a chip, the memory 601, the processor 602 and the communication interface 603 can communicate with each other through an internal interface.

[0107] The processor 602 may be a central processing unit (CPU), an application specific integrated circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of the present application.

[0108] An embodiment of the present application further provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the above-mentioned OCT-guided electroablation endoscopic method.

[0109] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or N embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0110] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features indicated. Thus, a feature specified as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of this application, "N" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0111] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, fragment or portion of code comprising one or more executable instructions for implementing the steps of a custom logical function or process, and the scope of the preferred embodiments of the present application includes alternative implementations in which functions may be performed out of the order shown or discussed, including performing functions in a substantially simultaneous manner or in reverse order depending on the functions involved, which should be understood by those skilled in the art to which the embodiments of the present application belong.

[0112] The logic and / or steps represented in the flowcharts or otherwise described herein, for example, can be considered as a sequenced list of executable instructions for implementing the logical functions, and can be embodied in any computer-readable medium for use by, or in conjunction with, an instruction execution system, apparatus, or device (e.g., a computer-based system, a system including a processor, or other system that can fetch and execute instructions from an instruction execution system, apparatus, or device). For purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate, or transport a program for use by, or in conjunction with, an instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of computer-readable media include the following: an electrical connection with one or N wires (electronic devices), a portable computer disk cartridge (magnetic device), random access memory (RAM), read-only memory (ROM), erasable and programmable read-only memory (EPROM or flash memory), fiber optic devices, and a portable compact disc read-only memory (CDROM). Furthermore, the computer-readable medium may even be paper or other suitable medium on which the program is printed, since the program may be obtained electronically, for example, by optically scanning the paper or other medium and then editing, interpreting or processing it in another suitable manner if necessary, and then storing it in a computer memory.

[0113] It should be understood that various parts of the present application can be implemented using hardware, software, firmware, or a combination thereof. In the above embodiment, the N steps or methods can be implemented using software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented using hardware, as in another embodiment, any one of the following technologies known in the art or a combination thereof can be used to implement: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application-specific integrated circuit having a suitable combination of logic gate circuits, a programmable gate array (PGA), a field programmable gate array (FPGA), etc.

[0114] Those skilled in the art will understand that all or part of the steps in the method of the above embodiment can be completed by instructing related hardware through a program, and the program can be stored in a computer-readable storage medium. When the program is executed, it includes one or a combination of the steps of the method embodiment.

[0115] In addition, the functional units in the various embodiments of the present application may be integrated into a processing module, or each unit may exist physically separately, or two or more units may be integrated into a module. The above-mentioned integrated module may be implemented in the form of hardware or in the form of a software functional module. If the integrated module is implemented in the form of a software functional module and sold or used as an independent product, it may also be stored in a computer-readable storage medium.

[0116] The storage medium mentioned above may be a read-only memory, a magnetic disk, or an optical disk, etc. Although the embodiments of the present application have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present application. Persons skilled in the art may make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present application.

Claims

1. An OCT-guided electroablation endoscopic probe, characterized in that: include: An OCT monitoring module is configured to output a scanning beam to scan and image the target tissue, obtain a microstructure image of the target tissue, and determine a target area to be ablated based on the microstructure image of the target tissue; An electrical ablation electrode array is used to perform electrical ablation on the target area to be ablated; The temperature detection component is used to obtain the temperature value of the target area to be ablated during the electroablation process, so as to maintain the current electroablation parameters of the electroablation electrode array according to the temperature value of the target area to be ablated, or adjust the current electroablation parameters of the electroablation electrode array.

2. The OCT-guided electroablation endoscopic probe according to claim 1, characterized in that: The OCT monitoring module includes: OCT imaging optical fiber, used for outputting the scanning light beam; a first reflecting mirror, configured to transmit the output scanning light beam to a target tissue; a second reflecting mirror, used for reflecting the output scanning light beam; The MEMS galvanometer is used to reflect the scanning light beam and achieve scanning within a preset angle range.

3. The OCT-guided electroablation endoscopic probe according to claim 1, characterized in that: The shape and size of the electroablation electrode array are both adjustable. The electroablation electrode array is connected to an external electroablation generator. The electroablation electrode array is also used for: The target area to be ablated is electrically ablated according to the adjusted new electrical ablation parameters.

4. The OCT-guided electroablation endoscopic probe according to claim 2, characterized in that: The first reflector is an ellipsoidal reflector.

5. The OCT-guided electroablation endoscopic probe according to claim 2, characterized in that: The second reflector is a plane reflector.

6. The OCT-guided electroablation endoscopic probe according to claim 1, characterized in that: Also includes: A data processing component is used to process the microstructure image of the target tissue, the current electrical ablation parameters and the temperature value of the target area to be ablated.

7. The OCT-guided electroablation endoscopic probe according to claim 1, characterized in that: Also includes: The early warning alarm module is used to issue an early warning alarm when the temperature value of the target area to be ablated is greater than a preset temperature value.

8. An OCT-guided electroablation endoscopic method, characterized in that: The OCT-guided electroablation endoscopic probe according to any one of claims 1 to 7 is used, wherein the method comprises the following steps: Scanning and imaging the target tissue using the OCT monitoring module to obtain a microstructure image of the target tissue; Determining a target area to be ablated according to the microstructure image of the target tissue, performing electroablation on the target area to be ablated using the electroablation electrode array, and obtaining a temperature value of the target area to be ablated during the electroablation process using the temperature detection component; The current electroablation parameters of the electroablation electrode array are adjusted based on the temperature value of the target area to be ablated, and the target area to be ablated is electroablated based on the adjusted new electroablation parameters.

9. An electronic device, characterized in that: include: A memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the computer program to implement the OCT-guided electroablation endoscopic method according to claim 8.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: The computer program is executed by a processor to implement the OCT-guided electroablation endoscopic method according to claim 8 .

Images