Sample sampling device for hematologic tumor

Abstract

The invention belongs to the technical field of tumor sampling, and provides a sample sampling device for hematologic tumors, which comprises a main needle cylinder, a collection cavity and a negative pressure cavity are arranged in the main needle cylinder, a piston assembly is arranged between the collection cavity and the negative pressure cavity, and the piston assembly is used for generating negative pressure in the negative pressure cavity and the collection cavity in sequence; one end of the connecting cylinder is detachably connected with the end, close to the collecting cavity, of the main needle cylinder, a main flow channel and a waste liquid collecting cavity are formed in the connecting cylinder, one end of the main flow channel communicates with the collecting cavity, the waste liquid collecting cavity communicates with the side wall of the main flow channel, and the waste liquid collecting cavity communicates with the negative pressure cavity; one end of the needle loading tube is detachably connected with one end, far away from the main needle cylinder, of the connecting cylinder, and a sampling needle head is arranged in the needle loading tube and is communicated with the other end of the main flow channel. The device can automatically remove the blood sample at the initial sampling stage, and only keeps the blood sample behind the first section of the sample.

Description

Technical Field

[0001] The invention belongs to the technical field of tumor sampling, and in particular relates to a blood tumor specimen sampling device. Background Art

[0002] A tumor is a neoplasm formed when a cell's genes undergo genetic alterations under the influence of carcinogenic factors, leading to a loss of normal growth regulation and resulting in monoclonal abnormal proliferation. These neoplasms often form localized masses, hence the name. Tumors can be divided into two main categories: benign and malignant. Tumor cells, transformed from normal cells, possess abnormal morphology, metabolism, and function, losing their ability to differentiate and mature to varying degrees. They grow vigorously and relatively autonomously, and can continue to grow even after the tumorigenic factors are no longer present.

[0003] To evaluate clinical efficacy and safety, patient pathology and blood sample analysis are often required. Sample quality directly impacts the accuracy of molecular testing. Existing blood tumor sample collection devices can easily cause cell compression and deformation during needle insertion, resulting in a certain percentage of failed samples in the initially collected blood tumor samples that need to be removed. However, existing sample collection devices are unable to automatically remove samples from the initial sampling process. Summary of the Invention

[0004] The purpose of the present invention is to provide a blood tumor specimen sampling device to solve the above-mentioned problem and automatically remove the blood tumor in the early stage of sampling and only retain the blood sample after the first section of the sample.

[0005] To achieve the above-mentioned object, the present invention provides the following solution: a blood tumor specimen sampling device, comprising:

[0006] A main syringe, wherein a collecting chamber and a negative pressure chamber are provided in the main syringe, a piston assembly is provided between the collecting chamber and the negative pressure chamber, and the piston assembly is used to generate negative pressure in the negative pressure chamber and the collecting chamber in sequence;

[0007] A connecting cylinder, one end of which is detachably connected to an end of the main syringe near the collection chamber, a main channel and a waste liquid collection chamber are provided in the connecting cylinder, one end of the main channel is in communication with the collection chamber, the waste liquid collection chamber is in communication with the side wall of the main channel, and the waste liquid collection chamber is in communication with the negative pressure chamber;

[0008] A needle-loading tube, one end of which is detachably connected to an end of the connecting tube away from the main syringe, a sampling needle is provided in the needle-loading tube, and the sampling needle is communicated with the other end of the main channel.

[0009] Preferably, the piston assembly includes a first piston slidably connected to the collecting chamber and a second piston slidably connected to the negative pressure chamber, an air pressure regulating member is provided between the second piston and the waste liquid collecting chamber, the first piston is fixedly connected to one end of a first pull rod at one end away from the connecting tube, the other end of the first pull rod extends out of the main syringe and is fixedly connected to a push-pull plate, the second piston is fixedly connected to one end of a second pull rod at one end close to the connecting tube, the other end of the second pull rod respectively passes through the negative pressure chamber and the collecting chamber and is fixedly connected to the side of the first piston away from the connecting tube through a sliding connecting member, the sliding connecting member is used to make the first piston in a stationary state at the initial stage of movement of the second piston.

[0010] Preferably, the air pressure regulating member comprises a communicating tube provided in the main syringe, one end of the communicating tube being in communication with the waste liquid collecting chamber, and the other end of the communicating tube being in communication with an end of the negative pressure chamber close to the collecting chamber;

[0011] It also includes a pressure relief hole, which is located on the side of the second piston away from the connecting cylinder. One end of the pressure relief hole is connected to the side wall of the negative pressure chamber, and the other end of the pressure relief hole passes through the side wall of the main syringe and is connected to the atmosphere. When the second piston moves to the side of the pressure relief hole away from the connecting cylinder, the sliding connection drives the first piston to move.

[0012] Preferably, the sliding connection includes a connecting column fixedly connected to the side of the first piston away from the connecting tube, the connecting column is coaxially arranged with the first piston, a sliding groove is opened along the axis in the connecting column, and the end of the second pull rod away from the first piston is slidably connected in the sliding groove through an abutment block, and the abutment block is arranged corresponding to the end of the sliding groove away from the first piston.

[0013] Preferably, one end of a branch channel is connected to the side wall of the main channel, the other end of the branch channel is connected to the waste liquid collection chamber, and a one-way valve is connected to the branch channel.

[0014] Preferably, the waste liquid collecting chamber is further connected with a ventilation pipe, and the ventilation pipe is connected with an end of the connecting pipe away from the negative pressure chamber.

[0015] Preferably, a second plug is fixedly connected to one end of the main syringe close to the connecting tube, and a first slot is opened inward on one side of the connecting tube close to the main syringe. The second plug is adapted to the first slot, and a liquid inlet channel is opened in the second plug. One end of the liquid inlet channel is connected to the collecting chamber, and the other end of the liquid inlet channel is connected to the main channel.

[0016] Preferably, a top plate is fixedly connected to the side of the sampling needle away from the tip, the top plate abuts against the end of the connecting tube, and a pressure sensor for measuring the contact pressure between the top plate and the connecting tube is provided in the top plate.

[0017] Preferably, a plurality of rubber pads are provided in the needle loading tube, and the rubber pads are evenly spaced around the axis of the sampling needle, and the rubber pads are in contact with the side wall of the sampling needle, and a piezoelectric sensor is abutted between the side of the rubber pads away from the sampling needle and the needle loading tube.

[0018] Preferably, a plurality of connecting buckles are respectively provided at both ends of the side wall of the connecting cylinder, and the plurality of connecting buckles are used to detachably connect the connecting cylinder with the main syringe and the needle tube.

[0019] Compared with the existing technology, the present invention has the following advantages and technical effects: the main function of the collection chamber is to collect blood and tumor samples after the first sample; the main function of the negative pressure chamber is to provide negative pressure in the waste liquid collection chamber at the initial stage of sampling, so that the first sample enters the waste liquid collection chamber; the main function of the piston assembly is to generate negative pressure in the negative pressure chamber and the collection chamber in sequence. Overall, the present invention uses the piston assembly to generate negative pressure in the negative pressure chamber and the collection chamber in sequence, so that the blood and tumor samples enter the waste liquid collection chamber and the collection chamber in sequence, so that the first sample at the initial stage of sampling automatically enters the waste liquid collection chamber, and subsequent samples can enter the collection chamber, realizing the separate sampling and collection of the first sample and subsequent samples, improving the sampling quality, and thereby improving the accuracy of molecular detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In this application, in order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 is a schematic cross-sectional view of the sampling device of the present invention;

[0022] Figure 2 It is a cross-sectional schematic diagram of the needle tube of the present invention;

[0023] Figure 3 It is a cross-sectional schematic diagram of the connecting tube of the present invention;

[0024] Figure 4 Schematic cross-sectional view of the main syringe of the present invention;

[0025] Among them, 1. main syringe; 2. connecting cylinder; 3. needle tube; 4. sampling needle; 5. first piston; 6. second piston; 7. first pull rod; 8. push-pull plate; 9. second pull rod; 10. sealing cover; 11. collecting chamber; 12. negative pressure chamber; 13. connecting pipe; 14. connecting column; 15. waste liquid collecting chamber; 16. connecting buckle; 17. one-way valve; 18. piezoelectric sensor; 19. rubber pad; 20. pressure sensor; 21. top plate; 22. branch channel; 23. main channel; 24. first slot; 25. first plug; 26. second slot; 27. slide groove; 28. abutment block; 29. liquid inlet channel; 30. second plug; 31. vent pipe; 32. pressure relief hole. DETAILED DESCRIPTION

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0027] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0028] In the prior art, there is a specimen sampling device for pediatric hematological tumors, comprising a syringe, a sealing cover installed at the rear end of the syringe, a booster mechanism installed on the inside of the syringe, and a fixed block fixedly installed on the inside of the syringe, wherein a blocking mechanism is installed at the front end of the booster mechanism, a sleeve is sleeved on the thin tube portion at the front end of the syringe, an adjustment mechanism is installed at the front end of the sleeve, a probe assembly is installed on the inside of the adjustment mechanism, an arched cavity for diversion is symmetrically opened inside the fixed block, and a fixing plug is installed at the front end of the sealing cover.

[0029] A card slot is provided between the sealing cover and the fixed plug. The sealing cover is fitted with the syringe through the fixed plug and the card slot, isolating the rear end of the syringe from the outside air to prevent foreign matter from entering the inner side of the syringe and causing contamination. The fixed block and the syringe are connected as a whole. The inner cavity of the sleeve is connected to the inner cavity of the syringe through the arched cavity. The arched cavity is used to divide the blood sample into two streams and collect them into the inner side of the syringe. The special structure of the arched cavity is utilized to liquid-seal the inner side of the fixed block with the help of the blood sample staying inside the arched cavity, and the blood sample collected inside the syringe is isolated between the fixed block and the piston to prevent the blood sample from being contaminated. An annular card slot is provided at the front end of the sleeve.

[0030] The boosting mechanism includes a cross push plate, a card slot is opened on the side wall of the cross push plate, and a slide groove is set on the surface of the cross push plate, and a piston fixedly connected to the front end of the cross push plate, wherein a storage cavity is opened at the front end of the piston, and the slide groove runs through the cross push plate, the piston and is connected to the storage cavity.

[0031] The front end of the cross push plate passes through the sealing cover and the fixing plug in sequence and is connected to the piston. The piston is embedded in the inner cavity of the syringe.

[0032] The blocking mechanism includes a thin rod, a plug, a baffle, and a hook plate. The thin rod is installed by inserting and placing the thin rod through a slide groove and a cross push plate. The front end of the thin rod is axially symmetrically connected to the two groups of plugs. The baffle is connected between the two groups of plugs, and the hook plate is embedded in the card slot.

[0033] A square slot is provided on the surface of the thin rod, the hook plate is assembled and installed with the thin rod through the square slot, and the plug and the blocking bar can be embedded in the piston through the receiving cavity.

[0034] The adjustment mechanism includes a needle loading tube, the rear end of the needle loading tube is connected to a clamping ring, and the needle loading tube is assembled and installed with the sleeve through the clamping ring and the annular groove. The front end of the needle loading tube is connected to a medical rubber pad, and the medical rubber pad and the needle loading tube are connected as a whole, and a threaded cavity is provided on the inside of the needle loading tube.

[0035] The needle-loading tube is sleeved on the thin tube part at the front end of the syringe through the sleeve, and the interior of the sleeve is hollow. By holding the sleeve with one hand and holding the needle-loading tube with the other hand and rotating it clockwise, the installation depth of the sampling needle on the inner side of the adjustment mechanism can be adjusted with the help of the interlocking installation of the thin tube part at the front end of the syringe and the baffle, thereby changing the depth of the sampling needle penetrating into the patient's lesion.

[0036] The probe assembly includes a sampling needle, the surface of which is provided with a threaded groove, and a baffle is connected to the rear end of the sampling needle. The sampling needle is threadedly installed with the needle tube through the cooperation of the threaded groove and the threaded cavity, thereby realizing the installation depth adjustment function between the sampling needle and the needle tube, and also ensuring that the penetration depth of the sampling needle is not affected by resistance when collecting blood samples.

[0037] The baffle is used to embed the rear end of the sampling needle into the thin tube part at the front end of the syringe, and the plug is used to block the arched cavity opened inside the fixed block, and the arched cavity passes through the fixed block and is connected to the inner cavity of the thin tube part.

[0038] The aforementioned sampling device can be used to transfer a blood sample by removing the hook plate mounted on the thin rod, disengaging the sealing cap and the booster mechanism, and quickly and smoothly pouring the blood sample out of the syringe's rear port. Furthermore, by grasping the cannula with one hand and the needle tube with the other and rotating it clockwise, the depth of the sampling needle installed inside the adjustment mechanism can be adjusted by interlocking the thin tube at the front end of the syringe with the retaining plate, thereby varying the depth at which the sampling needle penetrates the patient's lesion. Furthermore, the arched cavity is used to separate the blood sample into two streams and collect them inside the syringe, ensuring smooth blood sample collection while reducing the contact area between the front end of the syringe and the outside air. Furthermore, the unique structure of the arched cavity allows the blood sample retained inside the arched cavity to create a liquid seal against the inside of the fixed block, isolating the blood sample collected inside the syringe between the fixed block and the piston, preventing contamination of the blood sample. Furthermore, by inserting the plug into the arch cavity, the blood remaining in the arch cavity is sealed, and the liquid seal inside the arch cavity and the plug are used to re-seal the connection between the arch cavity and the inner cavity of the syringe, and the plug is used to cut off the connection between the blood inside the arch cavity and the blood in the inner cavity of the syringe, thereby completely solving the hidden danger of the blood sample in the inner cavity of the syringe being contaminated in a short time, and realizing the double storage insurance of the sampling device for the sterile storage of the blood sample.

[0039] Reference Figure 1-Figure 4 The present invention provides a blood tumor specimen sampling device, comprising:

[0040] The main syringe 1 is provided with a collecting chamber 11 and a negative pressure chamber 12. A piston assembly is provided between the collecting chamber 11 and the negative pressure chamber 12. The piston assembly is used to generate negative pressure in the negative pressure chamber 12 and the collecting chamber 11 in sequence.

[0041] Connecting tube 2, one end of which is detachably connected to the end of main syringe 1 near collecting chamber 11, and a main channel 23 and a waste liquid collecting chamber 15 are provided in connecting tube 2, one end of main channel 23 is in communication with collecting chamber 11, and waste liquid collecting chamber 15 is in communication with the side wall of main channel 23, and waste liquid collecting chamber 15 is in communication with negative pressure chamber 12;

[0042] The needle tube 3 has one end detachably connected to the end of the connecting tube 2 away from the main syringe 1 . A sampling needle 4 is arranged in the needle tube 3 , and the sampling needle 4 is connected to the other end of the main channel 23 .

[0043] The main function of the collection chamber 11 is to collect the blood and tumor samples after the first sample; the main function of the negative pressure chamber 12 is to provide negative pressure in the waste liquid collection chamber 15 at the initial stage of sampling, so that the first sample enters the waste liquid collection chamber 15; the main function of the piston assembly is to generate negative pressure in the negative pressure chamber 12 and the collection chamber 11 successively; the main channel 23 is to communicate with the sampling needle 4, so that the blood sample enters the waste liquid collection chamber 15 or the collection chamber 11. Overall, the present invention uses the piston assembly to generate negative pressure in the negative pressure chamber and the collection chamber successively, so that the blood and tumor samples enter the waste liquid collection chamber and the collection chamber successively, so that the first sample at the initial stage of sampling automatically enters the waste liquid collection chamber, and the subsequent samples can enter the collection chamber, realizing the separate sampling and collection of the first sample and the subsequent samples, improving the sampling quality, and thus improving the accuracy of molecular detection.

[0044] A further optimized solution is that the piston assembly includes a first piston 5 slidingly connected in the collecting chamber 11 and a second piston 6 slidingly connected in the negative pressure chamber 12, and an air pressure regulating member is provided between the second piston 6 and the waste liquid collecting chamber 15. The end of the first piston 5 away from the connecting tube 2 is fixedly connected to one end of the first pull rod 7, and the other end of the first pull rod 7 extends out of the main syringe 1 and is fixedly connected to the push-pull plate 8. The end of the second piston 6 close to the connecting tube 2 is fixedly connected to one end of the second pull rod 9, and the other end of the second pull rod 9 respectively passes through the negative pressure chamber 12 and the collecting chamber 11 and is fixedly connected to the side of the first piston 5 away from the connecting tube 2 through a sliding connection. The sliding connection is used to make the first piston 5 in a stationary state at the initial stage of movement of the second piston 6.

[0045] like Figure 1 As shown, the end of the main syringe 1 away from the connecting cylinder 2 is fixedly connected to the cover 10, and the first pull rod 7 passes through the cover 10. The main function of the cover 10 is to seal the open end of the negative pressure chamber 12.

[0046] When medical personnel pull the first rod 7 outward via the push-pull plate 8, the first rod 7 immediately drives the second piston 6 to move within the negative pressure chamber 12 toward the sealing cover 10, generating negative pressure at the left end of the negative pressure chamber 12. As the second piston 6 moves, it drives the first rod 7 toward the sealing cover 10. After the second piston 6 moves a certain distance, it drives the first piston 5 to move via the sliding connection, generating negative pressure at the left end of the collection chamber 11.

[0047] In a further optimized solution, the air pressure regulating member includes a connecting tube 13 provided in the main syringe 1, one end of the connecting tube 13 is connected to the waste liquid collecting chamber 15, and the other end of the connecting tube 13 is connected to the end of the negative pressure chamber 12 close to the collecting chamber 11;

[0048] It also includes a pressure relief hole 32, which is located on the side of the second piston 6 away from the connecting tube 2. One end of the pressure relief hole 32 is connected to the side wall of the negative pressure chamber 12, and the other end of the pressure relief hole 32 passes through the side wall of the main syringe 1 and is connected to the atmosphere. When the second piston 6 moves to the side of the pressure relief hole 32 away from the connecting tube 2, the sliding connection drives the first piston 5 to move.

[0049] like Figure 1 and Figure 3 As shown, during the initial rightward movement of the second piston 6, a negative pressure is generated on the left side of the negative pressure chamber 12, which in turn generates a negative pressure in the waste liquid collection chamber 15 through the connecting tube 13, thereby drawing a blood sample therein through the main channel 23 and the sampling needle 4. At this point, the first piston 5 remains stationary due to the influence of the sliding connection. When the second piston 6 moves to the point where its left side is to the right of the pressure relief hole 32, the left side of the negative pressure chamber 12 communicates with the outside world through the pressure relief hole 32. The negative pressure in the negative pressure chamber 12 and the waste liquid collection chamber 15 is no longer negative, and the blood sample no longer enters the waste liquid collection chamber 15.

[0050] To further optimize the solution, the sliding connection includes a connecting column 14 fixedly connected to the side of the first piston 5 away from the connecting tube 2. The connecting column 14 is coaxially arranged with the first piston 5. A sliding groove 27 is opened along the axis in the connecting column 14. The end of the second pull rod 9 away from the first piston 5 is slidingly connected in the sliding groove 27 through an abutment block 28. The abutment block 28 is arranged corresponding to the end of the sliding groove 27 away from the first piston 5.

[0051] like Figure 1 and Figure 4 As shown, when the second piston 6 moves to its left side and is located on the right side of the pressure relief hole 32, the abutment block 28 at the end of the second pull rod 9 abuts against the right end of the slide groove 27. As the push-pull plate 8 continues to move right, the negative pressure chamber 12 is no longer affected by the pressure relief hole 32. At the same time, the first piston 5 starts to move right. At this time, the blood sample enters the collection chamber 11 through the main channel 23, thereby collecting the blood sample tumor sample after the first blood sample.

[0052] According to a further optimized solution, one end of a branch channel 22 is connected to the side wall of the main channel 23 , the other end of the branch channel 22 is connected to the waste liquid collection chamber 15 , and a one-way valve 17 is connected to the branch channel 22 .

[0053] like Figure 1 and Figure 2 As shown, the main function of the one-way valve 17 is to allow the blood sample to enter the waste liquid collection chamber 15 only through the branch channel 22, ensuring that the blood sample in the waste liquid collection chamber 15 does not flow back into the main channel 23 through the branch channel 22. By providing the one-way valve 17, when the blood sample begins to be collected in the collection chamber 11, the blood sample in the waste liquid collection chamber 15 will not enter the main channel 23, thereby preventing the blood sample in the waste liquid collection chamber 15 from affecting the blood sample in the collection chamber 11.

[0054] As a further optimization solution, the waste liquid collecting chamber 15 is further connected with a ventilation pipe 31 , and the ventilation pipe 31 is connected with an end of the connecting pipe 13 away from the negative pressure chamber 12 .

[0055] To further optimize the solution, a first plug 25 is fixedly connected to one end of the connecting tube 2 close to the main syringe 1, and the ventilation tube 31 is opened in the first plug 25. A second slot 26 is opened inwardly at one end of the main syringe 1 close to the connecting tube 2, and the first plug 25 is adapted to the second slot 26.

[0056] like Figure 1 、 Figure 3 and Figure 4 As shown, when the main syringe 1 and the connecting syringe 2 are connected, the first plug 25 is inserted into the second slot 26 to ensure a good connection between the vent tube 31 and the connecting tube 13 .

[0057] To further optimize the solution, a second plug 30 is fixedly connected to one end of the main syringe 1 close to the connecting tube 2, and a first slot 24 is opened inward on the side of the connecting tube 2 close to the main syringe 1. The second plug 30 is adapted to the first slot 24, and a liquid inlet channel 29 is opened in the second plug 30. One end of the liquid inlet channel 29 is connected to the collecting chamber 11, and the other end of the liquid inlet channel 29 is connected to the main channel 23.

[0058] like Figure 1 、 Figure 3 and Figure 4 As shown, when connecting the main syringe 1 and the connecting cylinder 2, by inserting the second plug 30 into the first slot 24, a good connection between the main channel 23 and the liquid inlet channel 29 can be ensured. At the same time, by providing the second plug 30, the opening of the liquid inlet channel 29 and the opening of the second slot 26 are not in the same plane. After the connecting cylinder 2 is removed, the blood sample at the second slot 26 can be effectively prevented from flowing into the liquid inlet channel 29, which can effectively prevent contamination between samples.

[0059] To further optimize the solution, a top plate 21 is fixedly connected to the side of the sampling needle 4 away from the tip, the top plate 21 abuts against the end of the connecting tube 2, and a pressure sensor 20 for measuring the contact pressure between the top plate 21 and the connecting tube 2 is provided in the top plate 21.

[0060] like Figure 1 and Figure 2 As shown, during the insertion process, the force of the sampling needle 4 contacting the human tissue can be transmitted to the connecting tube 2 through the top plate 21. By setting the pressure sensor 20, the insertion pressure can be fed back in real time.

[0061] To further optimize the solution, a plurality of rubber pads 19 are provided in the needle tube 3. The rubber pads 19 are evenly spaced around the axis of the sampling needle 4, and the rubber pads 19 are in contact with the side wall of the sampling needle 4. A piezoelectric sensor 18 is abutted between the side of the rubber pads 19 away from the sampling needle 4 and the needle tube 3.

[0062] like Figure 1 and Figure 2 As shown, during the insertion process, if the main syringe 1 deflects, the pressure between the circumferential sidewalls of the sampling needle 4 and the needle-loading tube 3 will change. When the sampling needle 4 deflects in a certain direction relative to the needle-loading tube 3, the monitoring values of the piezoelectric sensors 18 around the sampling needle 4 will change. Each piezoelectric sensor 18 transmits the monitoring value to the host computer, which analyzes and provides feedback on the deviation of the sampling needle 4 during the insertion process, helping to improve insertion accuracy.

[0063] As a further optimization solution, a plurality of connecting buckles 16 are respectively provided at both ends of the side wall of the connecting tube 2, and the plurality of connecting buckles 16 are used to detachably connect the connecting tube 2 with the main syringe 1 and the needle tube 3.

[0064] like Figure 1 As shown, the main function of the connecting buckle 16 is to connect the two ends of the connecting cylinder 2 to the main syringe 1 and the needle tube 3 respectively, and to facilitate the disassembly between the three.

[0065] The usage process of this embodiment is as follows:

[0066] Connect the two sides of the connecting cylinder 2 to the main syringe 1 and the needle-loading tube 3 respectively, and ensure that the push-pull plate 8 is in a position close to the main syringe 1.

[0067] The medical staff holds the main syringe 1 and inserts the sampling needle 4 into the patient's body at the location where the blood sample needs to be collected. Then, they pull the push-pull plate 8 outward, and the first piston 5 moves backward first, generating negative pressure in the negative pressure chamber 12 and generating negative pressure in the waste liquid collection chamber 15 through the connecting tube 13, so that the first section of blood sample passes through the sampling needle 4, the main channel 23, the branch channel 22 and the one-way valve 17 and enters the waste liquid collection chamber 15. Then, as the push-pull plate 8 continues to move backward, the second piston 6 moves to the right side of the pressure relief hole 32, and the second pull rod 9 begins to drive the first piston 5 backward. At this time, negative pressure is generated in the collection chamber 11, and the blood sample enters the collection chamber 11 through the main channel 23 and the liquid inlet channel 29.

[0068] After the sampling is completed, the connecting tube 2 is removed from the main syringe 1, and the push-pull plate 8 is pushed inward to discharge the blood sample in the collection chamber 11. At the same time, the blood sample in the waste liquid collection chamber 15 can be poured out through the ventilation tube 31.

[0069] In the description of the present invention, it should be understood that the terms "longitudinal", "transverse", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0070] The embodiments described above are merely descriptions of preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Without departing from the spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by persons skilled in the art should fall within the scope of protection defined by the claims of the present invention.

Claims

1. A blood tumor specimen sampling device, characterized in that: include: A main syringe (1), wherein a collecting chamber (11) and a negative pressure chamber (12) are provided in the main syringe (1), a piston assembly is provided between the collecting chamber (11) and the negative pressure chamber (12), and the piston assembly is used to generate negative pressure in the negative pressure chamber (12) and the collecting chamber (11) in sequence; A connecting tube (2), one end of the connecting tube (2) is detachably connected to one end of the main syringe (1) near the collecting chamber (11), a main channel (23) and a waste liquid collecting chamber (15) are provided in the connecting tube (2), one end of the main channel (23) is in communication with the collecting chamber (11), the waste liquid collecting chamber (15) is in communication with the side wall of the main channel (23), and the waste liquid collecting chamber (15) is in communication with the negative pressure chamber (12); A needle-loading tube (3), one end of which is detachably connected to an end of the connecting tube (2) away from the main syringe (1), a sampling needle (4) is provided in the needle-loading tube (3), and the sampling needle (4) is communicated with the other end of the main channel (23).

2. The blood tumor specimen sampling device according to claim 1, characterized in that: The piston assembly includes a first piston (5) slidably connected to the collection chamber (11) and a second piston (6) slidably connected to the negative pressure chamber (12), an air pressure regulating member is provided between the second piston (6) and the waste liquid collection chamber (15), the end of the first piston (5) away from the connecting tube (2) is fixedly connected to one end of the first pull rod (7), the other end of the first pull rod (7) extends out of the main syringe (1) and is fixedly connected to a push-pull plate (8), the end of the second piston (6) close to the connecting tube (2) is fixedly connected to one end of the second pull rod (9), the other end of the second pull rod (9) respectively passes through the negative pressure chamber (12) and the collection chamber (11) and is fixedly connected to the side of the first piston (5) away from the connecting tube (2) through a sliding connection, and the sliding connection is used to make the first piston (5) in a stationary state at the initial stage of movement of the second piston (6).

3. The blood tumor specimen sampling device according to claim 2, characterized in that: The air pressure regulating member comprises a communicating tube (13) disposed in the main syringe (1), one end of the communicating tube (13) being in communication with the waste liquid collecting chamber (15), and the other end of the communicating tube (13) being in communication with an end of the negative pressure chamber (12) close to the collecting chamber (11); It also includes a pressure relief hole (32), which is located on the side of the second piston (6) away from the connecting cylinder (2), one end of the pressure relief hole (32) is connected to the side wall of the negative pressure chamber (12), and the other end of the pressure relief hole (32) passes through the side wall of the main syringe (1) and is connected to the atmosphere. When the second piston (6) moves to the side of the pressure relief hole (32) away from the connecting cylinder (2), the sliding connection drives the first piston (5) to move.

4. The blood tumor specimen sampling device according to claim 3, characterized in that: The sliding connection includes a connecting column (14) fixedly connected to the side of the first piston (5) away from the connecting tube (2), the connecting column (14) and the first piston (5) are arranged coaxially, a sliding groove (27) is opened along the axis in the connecting column (14), and the end of the second pull rod (9) away from the first piston (5) is slidably connected in the sliding groove (27) through an abutment block (28), and the abutment block (28) is arranged corresponding to the end of the sliding groove (27) away from the first piston (5).

5. The blood tumor specimen sampling device according to claim 1, characterized in that: One end of a branch channel (22) is connected to the side wall of the main channel (23), the other end of the branch channel (22) is connected to the waste liquid collection chamber (15), and a one-way valve (17) is connected to the branch channel (22).

6. The blood tumor specimen sampling device according to claim 3, characterized in that: The waste liquid collecting chamber (15) is also connected to a vent pipe (31), and the vent pipe (31) is connected to an end of the connecting pipe (13) away from the negative pressure chamber (12).

7. The blood tumor specimen sampling device according to claim 1, characterized in that: The main syringe (1) is fixedly connected to one end of the connecting cylinder (2) close to the main syringe (1) with a second plug (30); the connecting cylinder (2) is provided with a first slot (24) inwardly on one side close to the main syringe (1); the second plug (30) is adapted to the first slot (24); a liquid inlet channel (29) is provided in the second plug (30); one end of the liquid inlet channel (29) is communicated with the collecting chamber (11), and the other end of the liquid inlet channel (29) is communicated with the main channel (23).

8. The blood tumor specimen sampling device according to claim 1, characterized in that: A top plate (21) is fixedly connected to the side of the sampling needle (4) away from the tip, the top plate (21) abuts against the end of the connecting tube (2), and a pressure sensor (20) for measuring the contact pressure between the top plate (21) and the connecting tube (2) is provided in the top plate (21).

9. The blood tumor specimen sampling device according to claim 1, characterized in that: A plurality of rubber pads (19) are provided in the needle-loading tube (3), and the plurality of rubber pads (19) are distributed at equal intervals around the axis of the sampling needle (4). The plurality of rubber pads (19) are in contact with the side wall of the sampling needle (4), and a piezoelectric sensor (18) is abutted between the side of the plurality of rubber pads (19) away from the sampling needle (4) and the needle-loading tube (3).

10. The blood tumor specimen sampling device according to claim 1, characterized in that: A plurality of connecting buckles (16) are respectively provided at both ends of the side wall of the connecting cylinder (2), and the plurality of connecting buckles (16) are used to detachably connect the connecting cylinder (2) with the main syringe (1) and the needle tube (3).

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