Device for injecting caudal vein of mouse

Abstract

The invention provides a device for injecting caudal veins of mice, which relates to the field of biomedical engineering, and comprises a fixed table body, a mouse body fixing cylinder, a placing groove, a mouse tail fixing table, an overturning support frame, an overturning driving motor, a clamping chuck, a fixed adjusting mechanism and a tail overturning driving mechanism, the mouse body fixing cylinder is fixedly connected to the upper portion of the fixing table body. The placing groove is formed in the upper part of the mouse body fixing cylinder; the rat tail fixing table is fixedly connected to the rear side of the upper portion of the fixing table body. The overturning driving motor is fixedly connected to the upper end of the rear portion of the overturning supporting frame. The clamping chuck is rotationally connected to the front portion of the overturning supporting frame. The fixed adjusting mechanism is arranged on the upper portion of the interior of the fixed table body. The tail turning driving mechanism is arranged behind the mouse tail fixing table, intravenous injection operation of experimenters is facilitated, the mouse tail intravenous injection operation efficiency is improved, and the problems that the experimenters need to twist the mouse tail with one hand and operate an injector with the other hand during injection, and operation is inconvenient are solved.

Description

Technical Field

[0001] The invention relates to the technical field of biomedical engineering, and in particular to a device for injecting the tail vein of a mouse. Background Art

[0002] In biomedical experiments, mouse tail vein injection is a key technology for drug delivery, gene therapy, blood sampling and other operations. Currently, the commonly used tail vein injection method relies on manually fixing the mouse's tail, using a simple heating device (such as a constant temperature heating pad) or alcohol wiping to dilate the blood vessels, and then the experimenter uses a syringe to perform intravenous injection. The existing mainstream mouse fixation device uses a transparent plastic tube / plexiglass cabin (3-5cm in diameter, 8-12cm in length) as the core fixing structure, with one end closed (reserving breathing space for the mouse's head) and the other end opening a tail outlet (5-8mm in diameter, with an elastic rubber ring or sliding baffle with adjustable tightness) to reduce tail shaking by restricting the mouse's body activity.

[0003] The existing publication number is CN104799968B. A device for mouse tail vein and other superficial vein injections includes a base, a transparent cylinder, a front fixing member, and a rear fixing member. The rear fixing member has a notch, and ventilation holes are provided on both sides of the transparent cylinder. The base is a sealed cavity with a light source inside. The base includes a top plate, a bottom plate, and four side plates. An adjustable light-transmitting operation panel is hingedly connected to the top plate between the side plate facing the mouse's tail end and the top plate. A fixing plate facing the interior of the base is provided on this side of the top plate. The adjustable light-transmitting operation panel is provided with an angle adjustment screw for adjusting the angle between it and the fixing plate. The remaining three sides of the adjustable light-transmitting operation panel are provided with elastic light shields connected to adjacent sides of the base. This device fully ensures the safety of the operator to prevent bites from mice during injection, and the mice are securely fixed. The impact of the mouse's stress response on the experimental results is fully considered, making the experimental results more reliable.

[0004] However, in the existing intravenous injection of mice, the injection is generally performed in the veins on both sides of the midline of the ventral (lower) side of the mouse's tail to protect the mouse. During the injection, the experimenter needs to twist the mouse's tail with one hand and operate the syringe with the other hand, which makes the operation more inconvenient and affects the efficiency of the tail vein injection of the mouse. Summary of the Invention

[0005] In view of this, the present invention provides a device for injecting the tail vein of a mouse, which has the function of adjusting the internal space of the mouse body fixing cylinder, limiting the position of the mouse, avoiding the movement of the mouse body during injection, ensuring the stability of the mouse during injection, and at the same time, adding feed to the inside of the shielding feeding part, reducing the stress response of the mouse by allowing the mouse to eat, achieving the fixation of the mouse tail root, facilitating the fixation of the mouse body, making the entire device suitable for mice of different sizes, and improving the scope of application of the entire device, and the temperature of the three groups of electric heating elements is independently controlled, and the temperature increases from the back to the front. Add, forming a continuous temperature gradient (for example, 38℃ at the root → 36℃ in the middle → 34℃ at the tip). Gradient heating avoids local overheating and prevents burns. At the same time, it guides blood flow through the temperature difference, making the veins more full and easier to identify. Gradient heating simulates physiological temperature changes, which is close to the natural transition of mouse body temperature to ambient temperature, reducing the risk of thermal injury. Turn on the injection fill light. The injection fill light achieves a fill light effect during injection, making it easier for experimenters to find the needle position, avoiding the experimenters from manually flipping the mouse's tail, facilitating the experimenters' intravenous injection operations, and improving the efficiency of mouse tail vein injection operations.

[0006] The present invention provides a device for injecting the tail vein of a mouse, which specifically includes a fixing platform, a mouse body fixing cylinder, a placement slot, a mouse tail fixing platform, a flip support frame, a flip drive motor, a clamping chuck, a fixing adjustment mechanism and a tail flip drive mechanism; the mouse body fixing cylinder is fixedly connected to the top of the fixing platform, and the mouse body fixing cylinder is a transparent acrylic material structure; the placement slot is opened above the mouse body fixing cylinder; the mouse tail fixing platform is fixedly connected to the upper rear side of the fixing platform; the flip support frame is fixedly connected to the upper rear end of the fixing platform; the flip drive motor is fixedly connected to the rear upper end of the flip support frame; the clamping chuck is rotatably connected to the front of the flip support frame; the fixing adjustment mechanism is arranged on the upper interior of the fixing platform; and the tail flip drive mechanism is arranged at the rear of the mouse tail fixing platform.

[0007] Furthermore, the fixed adjustment mechanism includes: an adjustment drive worm and an adjustment drive worm wheel; the adjustment drive worm is rotatably connected to the internal front end of the fixed platform; the adjustment drive worm wheel is rotatably connected to the inside of the fixed platform, and the adjustment drive worm wheel is engaged with the adjustment drive worm.

[0008] Furthermore, the fixed adjustment mechanism also includes: a lifting drive gear, a lifting drive rack and an adjustment support plate; the lifting drive gear is coaxially fixedly connected to the right side of the adjustment drive worm gear; the lifting drive rack is slidably connected to the inside of the fixed platform, and the lifting drive rack is engaged with the lifting drive gear; the adjustment support plate is slidably connected to the inside and bottom of the mouse body fixing tube, and the lower end of the adjustment support plate is fixedly connected to the lifting drive rack.

[0009] Furthermore, the fixed adjustment mechanism also includes: a shielding adjustment part, a shielding locking bolt and a shielding feeding part; the shielding adjustment part is arranged at the internal front end of the mouse body fixing tube; the shielding locking bolt is threadedly connected to the upper end of the shielding adjustment part; the shielding feeding part is fixedly connected to the rear lower end of the shielding adjustment part.

[0010] Furthermore, the fixed adjustment mechanism also includes: a shielding compensating member; the shielding compensating member is slidably connected to the inner lower end of the shielding adjusting member, and the upper end of the shielding compensating member is connected to the shielding adjusting member through a spring.

[0011] Furthermore, the fixing and adjusting mechanism also includes: a tail fixing piece and a fixing locking bolt; the tail fixing piece is rotatably connected to the rear of the mouse body fixing tube, and the outer periphery of the tail fixing piece is fixedly connected with a plurality of rubber rod structures; the fixing locking bolt is threadedly connected to the rear of the tail fixing piece.

[0012] Furthermore, the tail-flipping drive mechanism includes: an electric heating element and a heating contact element; the electric heating element is provided in three groups, the three groups of electric heating elements are respectively connected to the external power supply, and the three groups of electric heating elements are respectively fixedly connected to the inner side of the rat tail fixing platform; the heating contact element is provided in three groups, the three groups of heating contact elements are all arc-shaped silicone material structures, and the three groups of heating contact elements are respectively fixedly connected above the electric heating element.

[0013] Furthermore, the tail-turning driving mechanism also includes: injection fill lights; two groups of injection fill lights are provided, and the two groups of injection fill lights are respectively fixedly connected to the upper inner side of the mouse tail fixing platform.

[0014] Furthermore, the tail-flipping drive mechanism also includes: a first magnifying bracket, a second magnifying bracket, a magnifying glass and a magnifying locking bolt; the first magnifying bracket is slidably connected to the right side of the rat tail fixing platform; the second magnifying bracket is slidably connected to the inner side of the first magnifying bracket; the magnifying glass is fixedly connected to the left side of the second magnifying bracket; and the magnifying locking bolt is threadedly connected to the right side of the second magnifying bracket.

[0015] Furthermore, the tail-flipping drive mechanism also includes: a tail-flipping drive pin and a tail-flipping drive groove wheel; the tail-flipping drive pin is rotatably connected to the front right side of the flip support frame, and the tail-flipping drive pin is transmission-connected to the flipping drive motor; the tail-flipping drive groove wheel is rotatably connected to the front left side of the flip support frame, and the tail-flipping drive groove wheel and the tail-flipping drive pin together constitute a groove wheel structure, and the tail-flipping drive groove wheel is coaxially fixedly connected to the rear of the clamping chuck.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The present invention adopts the setting of a fixed adjustment mechanism, and rotates and adjusts the driving worm according to the body size of the mouse. The rotation of the adjusting driving worm drives the rotation of the adjusting driving worm wheel, and the rotation of the adjusting driving worm wheel drives the rotation of the lifting driving gear. The rotation of the lifting driving gear drives the lifting driving rack to move up and down, and the up and down movement of the lifting driving rack drives the adjustment support plate to move up and down. The adjustment support plate moves up and down to adjust the internal space of the mouse body fixing cylinder. Then, the mouse is placed in the mouse body fixing cylinder so that the mouse tail is placed behind the placement groove. Then, the shielding adjustment member is slid backward. The shielding adjustment member moves backward to limit the mouse, avoid the mouse body movement during injection, and ensure the stability of the mouse injection. At the same time, feed can be added to the inside of the shielding feeding member, and the mouse stress response can be reduced by allowing the mouse to eat, which reduces the difficulty in operating the mouse. Finally, the tail fixing member is rotated. After the tail fixing member is rotated to squeeze the mouse tail, the fixing locking bolt is tightened to thereby fix the base of the mouse tail, facilitate the fixation of the mouse body, make the entire device suitable for mice of different sizes, and improve the applicability of the entire device.

[0018] The present invention sets a tail-flipping drive mechanism, passes the mouse tail through the clamping chuck, uses the clamping chuck to fix the mouse tail end, then moves the first magnifying bracket forward and backward, and moves the second magnifying bracket up and down. After the magnifying glass is adjusted to a suitable position, tightens the magnifying locking bolt, and the magnifying locking bolt fixes the second magnifying bracket. Then, the electric heating element is turned on, and the temperatures of the three groups of electric heating elements are independently controlled. The temperature increases from back to front, forming a continuous temperature gradient (such as 38°C at the root → 36°C in the middle → 34°C at the tip). Gradient heating avoids local overheating and prevents burns. At the same time, the temperature difference is used to guide blood flow, making the veins more full and easier to identify. The gradient heating simulates physiological temperature changes, which is close to the natural transition from the mouse body temperature to the ambient temperature, reducing the risk of thermal damage. The injection fill light is turned on, and the injection fill light achieves a fill light effect during injection, making it easier for experimenters to find the needle insertion position.

[0019] The present invention turns on a flipping drive motor by setting a tail-flipping drive mechanism, and the flipping drive motor drives a tail-flipping drive pin to rotate, and the rotation of the tail-flipping drive pin drives the rotation of the tail-flipping drive groove wheel, and the rotation of the tail-flipping drive groove wheel drives the rotation of the clamping chuck, and the rotation of the clamping chuck drives the mouse tail to flip, thereby avoiding manual flipping of the mouse tail by an experimenter, facilitating the intravenous injection operation of the experimenter, and improving the efficiency of the mouse tail intravenous injection operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings of the embodiments are briefly introduced below.

[0021] The drawings described below only relate to some embodiments of the present invention, but are not intended to limit the present invention.

[0022] In the attached figure:

[0023] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present invention.

[0024] Figure 2 It is a schematic diagram of the fixing and locking bolt structure of an embodiment of the present invention.

[0025] Figure 3 Schematic diagram of the tail fixing structure of an embodiment of the present invention.

[0026] Figure 4 2 is a schematic structural diagram of a shielding adjustment member according to an embodiment of the present invention.

[0027] Figure 5 2 is a schematic structural diagram of an occlusion compensation component according to an embodiment of the present invention.

[0028] Figure 6 Schematic diagram of the heating contact structure of an embodiment of the present invention.

[0029] Figure 7 It is a schematic diagram of the tail-flipping drive sheave structure of an embodiment of the present invention.

[0030] Figure 8 It is a structural schematic diagram of an injection fill light according to an embodiment of the present invention.

[0031] Reference Signs List

[0032] 1. Fixed platform; 101. Adjusting drive worm; 102. Adjusting drive worm gear; 103. Lifting drive gear; 104. Lifting drive rack; 105. Adjusting support plate; 106. Shielding adjustment member; 107. Shielding locking bolt; 108. Shielding feeding member; 109. Shielding compensation member; 110. Tail fixing member; 111. Fixing locking bolt; 2. Mouse body fixing tube; 3. Placement slot; 4. Mouse tail fixing platform; 5. Flipping support frame; 6. Flipping drive motor; 7. Clamping chuck; 701. Electric heating member; 702. Heating contact member; 703. Injection fill light; 704. First magnifying bracket; 705. Second magnifying bracket; 706. Magnifying glass; 707. Magnifying locking bolt; 708. Flipping tail drive pin; 709. Flipping tail drive sheave. DETAILED DESCRIPTION

[0033] Example 1:

[0034] Please refer to Figures 1 to 5 As shown:

[0035] The present invention provides a device for injecting the tail vein of a mouse, comprising a fixing platform 1, a mouse body fixing cylinder 2, a placement groove 3, a mouse tail fixing platform 4, a flip support frame 5, a flip drive motor 6, a clamping chuck 7 and a fixing adjustment mechanism; the mouse body fixing cylinder 2 is fixedly connected to the top of the fixing platform 1, and the mouse body fixing cylinder 2 is a transparent acrylic material structure; the placement groove 3 is opened above the mouse body fixing cylinder 2; the mouse tail fixing platform 4 is fixedly connected to the upper rear side of the fixing platform 1; the flip support frame 5 is fixedly connected to the upper rear end of the fixing platform 1; the flip drive motor 6 is fixedly connected to the rear upper end of the flip support frame 5; the clamping chuck 7 is rotatably connected to the front of the flip support frame 5; and the fixing adjustment mechanism is arranged on the upper interior of the fixing platform 1.

[0036] Among them, the fixed adjustment mechanism includes: an adjustment drive worm 101 and an adjustment drive worm wheel 102; the adjustment drive worm 101 is rotatably connected to the internal front end of the fixed platform body 1; the adjustment drive worm wheel 102 is rotatably connected to the inside of the fixed platform body 1, and the adjustment drive worm wheel 102 is engaged with the adjustment drive worm 101.

[0037] Among them, the fixed adjustment mechanism also includes: a lifting drive gear 103, a lifting drive rack 104 and an adjustment support plate 105; the lifting drive gear 103 is coaxially fixedly connected to the right side of the adjustment drive worm gear 102; the lifting drive rack 104 is slidably connected to the inside of the fixed platform 1, and the lifting drive rack 104 is engaged with the lifting drive gear 103; the adjustment support plate 105 is slidably connected to the inside and bottom of the mouse body fixing tube 2, and the lower end of the adjustment support plate 105 is fixedly connected to the lifting drive rack 104.

[0038] Among them, the fixed adjustment mechanism also includes: a shielding adjustment part 106, a shielding locking bolt 107 and a shielding feeding part 108; the shielding adjustment part 106 is arranged at the internal front end of the mouse body fixing tube 2; the shielding locking bolt 107 is threadedly connected to the upper end of the shielding adjustment part 106; and the shielding feeding part 108 is fixedly connected to the rear lower end of the shielding adjustment part 106.

[0039] The fixed adjustment mechanism further includes: a shielding compensating member 109 ; the shielding compensating member 109 is slidably connected to the inner lower end of the shielding adjusting member 106 , and the upper end of the shielding compensating member 109 is connected to the shielding adjusting member 106 via a spring.

[0040] Among them, the fixing and adjusting mechanism also includes: a tail fixing part 110 and a fixing locking bolt 111; the tail fixing part 110 is rotatably connected to the rear of the mouse body fixing tube 2, and the outer periphery of the tail fixing part 110 is fixedly connected with a plurality of rubber rod structures; the fixing locking bolt 111 is threadedly connected to the rear of the tail fixing part 110.

[0041] The specific usage and function of this embodiment are as follows: when it is necessary to inject the tail vein of a mouse, first, the driving worm 101 is rotated and adjusted according to the body size of the mouse. The rotation of the driving worm 101 drives the rotation of the driving worm wheel 102, and the rotation of the driving worm wheel 102 drives the lifting driving gear 103 to rotate. The rotation of the lifting driving gear 103 drives the lifting driving rack 104 to move up and down. The lifting driving rack 104 moves up and down and drives the adjusting support plate 105 to move up and down. The upward and downward movement of the adjusting support plate 105 realizes the adjustment of the internal space of the mouse body fixing cylinder 2. Then, the mouse is placed in the mouse body fixing cylinder 2 so that the mouse tail is placed in the placement slot 3. At the same time, feed can be added to the inside of the shielding feeding part 108, which can reduce the stress response of the mouse by letting the mouse eat. Finally, the tail fixing part 110 is rotated. After the tail fixing part 110 is rotated to squeeze the mouse's tail, the locking bolt 111 is tightened to fix the base of the mouse's tail, thereby facilitating the fixation of the mouse's body, making the entire device suitable for mice of different sizes, and improving the scope of application of the entire device.

[0042] Example 2:

[0043] like Figures 1 to 8 As shown:

[0044] The present invention provides a device for injecting into the tail vein of a mouse. Based on the first embodiment, the device further comprises a tail-flipping drive mechanism, which is arranged behind the mouse tail fixing platform 4 .

[0045] Among them, the tail-flipping drive mechanism includes: an electric heating element 701 and a heating contact element 702; there are three groups of electric heating elements 701, and the three groups of electric heating elements 701 are respectively connected to the external power supply, and the three groups of electric heating elements 701 are respectively fixedly connected to the inner side of the rat tail fixing platform 4; there are three groups of heating contact elements 702, and the three groups of heating contact elements 702 are all arc-shaped silicone material structures, and the three groups of heating contact elements 702 are respectively fixedly connected above the electric heating element 701.

[0046] The tail-turning driving mechanism further includes: injection fill lights 703 ; two groups of injection fill lights 703 are provided, and the two groups of injection fill lights 703 are respectively fixedly connected to the upper inner side of the mouse tail fixing platform 4 .

[0047] Among them, the tail-flipping drive mechanism also includes: a first magnifying bracket 704, a second magnifying bracket 705, a magnifying glass 706 and a magnifying locking bolt 707; the first magnifying bracket 704 is slidably connected to the right side of the rat tail fixing platform 4; the second magnifying bracket 705 is slidably connected to the inner side of the first magnifying bracket 704; the magnifying glass 706 is fixedly connected to the left side of the second magnifying bracket 705; and the magnifying locking bolt 707 is threadedly connected to the right side of the second magnifying bracket 705.

[0048] Among them, the tail-flipping drive mechanism also includes: a tail-flipping drive pin 708 and a tail-flipping drive groove wheel 709; the tail-flipping drive pin 708 is rotatably connected to the front right side of the flip support frame 5, and the tail-flipping drive pin 708 is transmission-connected to the flipping drive motor 6; the tail-flipping drive groove wheel 709 is rotatably connected to the front left side of the flip support frame 5, and the tail-flipping drive groove wheel 709 and the tail-flipping drive pin 708 together constitute a groove wheel structure, and the tail-flipping drive groove wheel 709 is coaxially fixedly connected to the rear of the clamping chuck 7.

[0049] The specific usage and function of this embodiment are as follows: when injecting into the mouse's tail vein, the mouse's tail is passed through the clamping chuck 7, and the clamping chuck 7 is used to fix the end of the mouse's tail. Then, the first magnifying bracket 704 is moved forward and backward, and the second magnifying bracket 705 is moved up and down. After the magnifying glass 706 is adjusted to a suitable position, the magnifying locking bolt 707 is tightened. The magnifying locking bolt 707 fixes the second magnifying bracket 705. Then, the electric heating element 701 is turned on. The temperatures of the three groups of electric heating elements 701 are independently controlled. The temperatures increase from the back to the front, forming a continuous temperature gradient, for example, 38°C at the root → 36°C in the middle → 34°C at the tip. The gradient heating avoids local overheating and prevents burns. At the same time, the temperature difference guides the blood flow. The vein is more full and easier to identify. The gradient heating simulates the physiological temperature change to be close to the natural transition of the mouse body temperature to the ambient temperature, reducing the risk of thermal injury. The injection fill light 703 is turned on. The injection fill light 703 realizes the fill light effect during injection, making it easier for the experimenter to find the needle insertion position. Finally, the flip drive motor 6 is turned on. The flip drive motor 6 drives the tail flip drive pin 708 to rotate. The rotation of the tail flip drive pin 708 drives the tail flip drive groove wheel 709 to rotate. The rotation of the tail flip drive groove wheel 709 drives the clamping chuck 7 to rotate. The rotation of the clamping chuck 7 drives the mouse tail to flip, avoiding the experimenter manually flipping the mouse tail, facilitating the experimenter's intravenous injection operation, and improving the efficiency of the mouse tail vein injection operation.

Claims

1. A device for injecting into the tail vein of a mouse, characterized in that: The invention comprises a fixed platform (1), a mouse body fixing cylinder (2), a placement groove (3), a mouse tail fixing platform (4), a flip support frame (5), a flip drive motor (6), a clamping chuck (7), a fixed adjustment mechanism and a flip drive mechanism; the mouse body fixing cylinder (2) is fixedly connected to the top of the fixed platform (1), and the mouse body fixing cylinder (2) is a transparent acrylic material structure; the placement groove (3) is opened above the mouse body fixing cylinder (2); the mouse tail fixing platform (4) is fixedly connected to the upper rear side of the fixed platform (1); the flip support frame (5) is fixedly connected to the upper rear end of the fixed platform (1); the flip drive motor (6) is fixedly connected to the rear upper end of the flip support frame (5); the clamping chuck (7) is rotatably connected to the front of the flip support frame (5); the fixed adjustment mechanism is arranged on the upper interior of the fixed platform (1); and the flip drive mechanism is arranged at the rear of the mouse tail fixing platform (4).

2. A device for mouse tail vein injection according to claim 1, characterized in that: The fixed adjustment mechanism comprises: an adjustment drive worm (101) and an adjustment drive worm wheel (102); the adjustment drive worm (101) is rotatably connected to the front end of the interior of the fixed platform (1); the adjustment drive worm wheel (102) is rotatably connected to the interior of the fixed platform (1), and the adjustment drive worm wheel (102) is meshed with the adjustment drive worm (101).

3. A device for mouse tail vein injection according to claim 2, characterized in that: The fixed adjustment mechanism further comprises: a lifting drive gear (103), a lifting drive rack (104) and an adjustment support plate (105); the lifting drive gear (103) is coaxially fixedly connected to the right side of the adjustment drive worm gear (102); the lifting drive rack (104) is slidably connected to the inside of the fixed platform (1), and the lifting drive rack (104) is meshed with the lifting drive gear (103); the adjustment support plate (105) is slidably connected to the inside and below of the mouse body fixing cylinder (2), and the lower end of the adjustment support plate (105) is fixedly connected to the lifting drive rack (104).

4. A device for mouse tail vein injection as claimed in claim 3, characterized in that: The fixing adjustment mechanism further comprises: a shielding adjustment member (106), a shielding locking bolt (107) and a shielding feeding member (108); the shielding adjustment member (106) is arranged at the inner front end of the mouse body fixing cylinder (2); the shielding locking bolt (107) is threadedly connected to the upper end of the shielding adjustment member (106); and the shielding feeding member (108) is fixedly connected to the rear lower end of the shielding adjustment member (106).

5. A device for mouse tail vein injection according to claim 4, characterized in that: The fixed adjustment mechanism further comprises: a shielding compensating member (109); the shielding compensating member (109) is slidably connected to the inner lower end of the shielding adjusting member (106); the upper end of the shielding compensating member (109) is connected to the shielding adjusting member (106) via a spring.

6. A device for mouse tail vein injection according to claim 5, characterized in that: The fixing and adjusting mechanism further comprises: a tail fixing member (110) and a fixing locking bolt (111); the tail fixing member (110) is rotatably connected to the rear of the mouse body fixing tube (2); a plurality of rubber rod structures are fixedly connected to the outer periphery of the tail fixing member (110); and the fixing locking bolt (111) is threadedly connected to the rear of the tail fixing member (110).

7. The device for mouse tail vein injection according to claim 1, wherein: The tail-turning drive mechanism comprises: an electric heating element (701) and a heating contact element (702); the electric heating element (701) is provided in three groups, the three groups of electric heating elements (701) are respectively connected to an external power supply, and the three groups of electric heating elements (701) are respectively fixedly connected to the inner side of the rat tail fixing platform (4); the heating contact element (702) is provided in three groups, the three groups of heating contact elements (702) are all arc-shaped silicone material structures, and the three groups of heating contact elements (702) are respectively fixedly connected above the electric heating element (701).

8. A device for mouse tail vein injection according to claim 7, characterized in that: The tail-turning driving mechanism further comprises: injection fill-in lights (703); two groups of injection fill-in lights (703) are provided, and the two groups of injection fill-in lights (703) are respectively fixedly connected to the upper inner side of the mouse tail fixing platform (4).

9. A device for mouse tail vein injection according to claim 8, characterized in that: The tail-turning driving mechanism further comprises: a first magnifying bracket (704), a second magnifying bracket (705), a magnifying glass (706) and a magnifying locking bolt (707); the first magnifying bracket (704) is slidably connected to the right side of the rat tail fixing platform (4); the second magnifying bracket (705) is slidably connected to the inner side of the first magnifying bracket (704); the magnifying glass (706) is fixedly connected to the left side of the second magnifying bracket (705); and the magnifying locking bolt (707) is threadedly connected to the right side of the second magnifying bracket (705).

10. The device for mouse tail vein injection according to claim 9, characterized in that: The tail-turning driving mechanism further comprises: a tail-turning driving pin (708) and a tail-turning driving groove wheel (709); the tail-turning driving pin (708) is rotatably connected to the front right side of the turning support frame (5), and the tail-turning driving pin (708) is transmission-connected to the turning driving motor (6); the tail-turning driving groove wheel (709) is rotatably connected to the front left side of the turning support frame (5), and the tail-turning driving groove wheel (709) and the tail-turning driving pin (708) together form a groove wheel structure, and the tail-turning driving groove wheel (709) is coaxially fixedly connected to the rear of the clamping chuck (7).

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