Combined medicine for treating scalds as well as preparation method and application thereof

Abstract

The invention relates to the technical field of medicines for treating scalds, and particularly discloses a combined medicine for treating scalds as well as a preparation method and application thereof. The invention discloses a combined medicine for treating scalds. The medicine for treating scalds is prepared from the following raw materials in parts by weight: 10-20 parts of earthworm powder and 35-45 parts of rapeseed oil. The preparation method of the combined medicine for treating the scalds comprises the following steps: uniformly stirring and mixing the earthworm powder, the rapeseed oil and other raw materials to obtain the combined medicine for treating the scalds. The earthworm powder is rich in active protein and growth factors, so that epidermal regeneration is promoted; the rapeseed oil contains more linoleic acid and can enhance skin barrier repair, so that the earthworm powder and the rapeseed oil are matched to achieve a good curative effect on the scalds.

Description

Technical Field

[0001] The present application relates to the technical field of scald medicines, and in particular to a combined scald treatment medicine, a preparation method thereof, and applications thereof. Background Art

[0002] Burns and scalds are common in real life. Mild burns can result in burns to the epidermis, severe burns to the dermis and subcutaneous fat tissue, and even more severe burns to the muscles, bones, and even internal organs. Extensive burns can cause systemic symptoms such as shock and can even lead to death. As a major player in traditional Chinese medicine, my country has accumulated extensive experience in treating these burns and scalds. In recent years, traditional Chinese medicine has published a variety of formulas for treating burns and scalds, each with varying efficacy. Commonly used burn ointments, made with ingredients such as Chuanxiong, Angelica dahurica, Phellodendron amurense, Bletilla striata, Sanguisorba officinalis, Red Stone Flakes, and Gallnut, can heal burns, but their effectiveness is generally slow. Summary of the Invention

[0003] In order to improve the efficacy of scald medicine, the present application provides a combined scald treatment medicine and its preparation method and application.

[0004] In a first aspect, the present application provides a combined medicament for treating burns, which adopts the following technical solution: A combined scald treating medicine comprises raw materials of the following components in parts by weight: 10 to 20 parts of earthworm powder and 35 to 45 parts of rapeseed oil.

[0005] By adopting the above technical solution, earthworm powder is rich in active proteins and growth factors, which promote epidermal regeneration; rapeseed oil contains more linoleic acid, which enhances skin barrier repair. Therefore, the combination of earthworm powder and rapeseed oil has a better therapeutic effect on burns.

[0006] In a specific embodiment, the method for preparing the earthworm powder comprises the following steps: Black earthworms are selected, their skins are peeled and their internal organs are removed, and then they are cleaned, disinfected and dried in the sun, ground into powder, and sieved with an 80-100 mesh filter to obtain earthworm powder.

[0007] In a specific embodiment, the method for preparing rapeseed oil comprises the following steps: Pretreatment: The rapeseed is passed through a vibrating screen to remove impurities such as sand and broken shells, then rinsed with clean water and dried until the moisture content is less than 8%; Oil pressing: Use a spiral cold press to press the oil, filter it, remove the large particles of oil residue, and obtain the virgin oil; Refining: The virgin oil is distilled at 160-180°C to obtain rapeseed oil.

[0008] By adopting the above technical solution and utilizing the above method, the rapeseed oil obtained can better retain the natural active ingredients.

[0009] In a specific embodiment, the raw materials of the burn treatment medicine further include 5 to 10 parts by weight of Manuka honey.

[0010] By adopting the above technical solution and adding Manuka honey, the methylglyoxal in Manuka honey can target and eliminate pathogens, reduce the risk of infection, provide a clean environment for the healing effect of earthworm powder, and prolong the duration of drug action.

[0011] In a specific embodiment, the raw materials of the burn treatment medicine further include 5 to 8 parts by weight of aloe polysaccharide and 3 to 5 parts by weight of asiaticoside.

[0012] By adopting the above technical solutions, aloe polysaccharides reduce the release of inflammatory factors and tissue edema, while asiatica glycoside stimulates collagen synthesis, accelerates wound closure, and enhances deep repair. The two work together to shorten the inflammatory period and accelerate the healing process.

[0013] In a specific embodiment, the raw materials of the burn treatment medicine further include 1 to 3 parts by weight of vitamin E acetate and 5 to 10 parts by weight of sodium alginate gel matrix.

[0014] By adopting the above technical solution, the sodium alginate gel matrix forms a breathable physical barrier, and rapeseed oil and vitamin E acetate construct a lipid chemical barrier. The double protection reduces external stimulation, stabilizes the formula, and prolongs the effectiveness of the active ingredients.

[0015] In a specific embodiment, the preparation method of the sodium alginate gel matrix comprises the following steps: adding sodium alginate to water, heating and stirring in a water bath to dissolve the sodium alginate to obtain a sodium alginate solution; then adding a citric acid buffer to adjust the pH of the sodium alginate solution to 6.5-7.0; and finally adding a calcium chloride solution dropwise and stirring until a uniform gel is formed to obtain a sodium alginate gel matrix.

[0016] In a second aspect, the present application provides a method for preparing a combined scald treatment drug, which adopts the following technical solution: A method for preparing a combined scald treating medicine comprises the following steps: The earthworm powder, rapeseed oil and other raw materials are stirred and mixed evenly to obtain a combined scald treating medicine.

[0017] By adopting the technical solution, the earthworm powder, rapeseed oil and other raw materials are stirred and mixed evenly to obtain a scald medicine that is better for treating scalds.

[0018] In a third aspect, the present application provides a combined medicament for treating burns, which adopts the following technical solution: An application of a combined burn treatment drug comprises the following steps: Clean and disinfect the skin wound, then apply the combination burn treatment medicine to the wound four to five times a day.

[0019] In summary, this application includes at least one of the following beneficial technical effects: 1. This application utilizes a combination of earthworm powder and rapeseed oil. Earthworm powder is rich in active proteins and growth factors, promoting epidermal regeneration; rapeseed oil contains a high amount of linoleic acid, which enhances skin barrier repair, thereby producing a burn medicine with excellent efficacy for burns. 2. Aloe polysaccharides in this application reduce the release of inflammatory factors and tissue edema, while asiaticoside stimulates collagen synthesis, accelerates wound closure, and enhances deep repair. The two synergistically shorten the inflammatory period and accelerate the healing process. 3. The method of the present application is to stir and mix earthworm powder, rapeseed oil and other raw materials to obtain a burn medicine that is better for treating burns. DETAILED DESCRIPTION

[0020] The present application is further described in detail below with reference to the embodiments.

[0021] All raw materials in the examples are commercially available. The black earthworms used were Hubei No. 2 black earthworms, and the citric acid buffer was provided by Shanghai Chuangsai Technology Co., Ltd., with the product number PM11251.

[0022] Preparation Example Preparation Example 1 Preparation Example 1 provides a method for preparing earthworm powder, comprising the following steps: Black earthworms are selected, their skins are peeled and their internal organs are removed, and then they are cleaned, disinfected and dried in the sun, ground into powder, and sieved with an 80-mesh filter to obtain earthworm powder.

[0023] Preparation Example 2 Preparation Example 2 provides a method for preparing earthworm powder, comprising the following steps: Black earthworms are selected, their skins are peeled and their internal organs are removed, and then they are cleaned, disinfected and dried in the sun, ground into powder, and sieved with a 90-mesh filter to obtain earthworm powder.

[0024] Preparation Example 3 Preparation Example 3 provides a method for preparing earthworm powder, comprising the following steps: Black earthworms are selected, their skins are peeled and their internal organs are removed, and then they are cleaned, disinfected and dried in the sun, ground into powder, and sieved with a 100-mesh filter to obtain earthworm powder.

[0025] Preparation Example 4 Preparation Example 4 provides a method for preparing rapeseed oil, comprising the following steps: Pretreatment: The rapeseed is passed through a vibrating screen to remove impurities such as sand and broken shells, then rinsed with clean water and then dried at 55°C until the moisture content is less than 8%; Oil pressing: Use a screw cold press to press the oil at a speed of 30 rpm and a temperature of 50°C. Filter through a 200-mesh filter cloth to remove large particles of oil residue to obtain the virgin oil. Refining: The virgin oil is distilled at 170°C and a vacuum degree of 0.5 mbar to obtain rapeseed oil.

[0026] Preparation Example 5 Preparation Example 5 provides a method for preparing a sodium alginate gel matrix, comprising the following steps: Sodium alginate was added to water, and heated in a water bath at 65° C. with stirring to dissolve the sodium alginate, thereby obtaining a sodium alginate solution containing 4% sodium alginate by weight. Then, a citric acid buffer solution was added to the sodium alginate solution to adjust the pH of the sodium alginate solution to 6.5; finally, a 2% by mass calcium chloride solution was added dropwise and stirred until a uniform gel was formed to obtain a sodium alginate gel matrix. Example

[0027] Example 1 Example 1 provides a method for preparing a combined scald treatment drug, comprising the following steps: 10 g of the earthworm powder prepared in Preparation Example 1 and 35 g of the rapeseed oil prepared in Preparation Example 4 were stirred and mixed to obtain a combined medicament for treating burns.

[0028] Example 2 Example 2 provides a method for preparing a combined scald treatment drug, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 1 and 40 g of the rapeseed oil prepared in Preparation Example 4 were stirred and mixed to obtain a combined medicament for treating burns.

[0029] Example 3 Example 3 provides a method for preparing a combined scald treatment drug, comprising the following steps: 20 g of the earthworm powder prepared in Preparation Example 1 and 45 g of the rapeseed oil prepared in Preparation Example 4 were stirred and mixed to obtain a combined medicament for treating burns.

[0030] Example 4 Example 4 provides a method for preparing a combined scald treatment drug, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 2 and 40 g of the rapeseed oil prepared in Preparation Example 4 were stirred and mixed to obtain a combined medicament for treating burns.

[0031] Example 5 Example 5 provides a method for preparing a combined scald treatment drug, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 3 and 40 g of the rapeseed oil prepared in Preparation Example 4 were stirred and mixed to obtain a combined medicament for treating burns.

[0032] Example 6 Example 6 provides a method for preparing a combined scald treatment drug, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 2 and 7.5 g of Manuka honey were added to 40 g of the rapeseed oil prepared in Preparation Example 4 and stirred to mix evenly to obtain a combined remedy for treating burns.

[0033] Example 7 Example 7 provides a method for preparing a combined medicament for treating burns, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 2, 7.5 g of Manuka honey, 6.5 g of aloe polysaccharide, and 4 g of asiaticaoside were added to 40 g of the rapeseed oil prepared in Preparation Example 4 and stirred to mix evenly to obtain a combined remedy for treating burns.

[0034] Example 8 Example 8 provides a method for preparing a combined scald treatment drug, comprising the following steps: 15 g of the earthworm powder prepared in Preparation Example 2, 7.5 g of Manuka honey, 6.5 g of aloe polysaccharide, 4 g of asiaticoside, 2 g of vitamin E acetate, and 7.5 g of the sodium alginate gel matrix prepared in Preparation Example 5 were added to 40 g of the rapeseed oil prepared in Preparation Example 4 and stirred to obtain a combined medicament for treating burns.

[0035] Comparative Example Comparative Example 1 Comparative Example 1 provides a method for preparing a scald external ointment, comprising the following steps: Mix 120g of Chuanxiong, 125g of Angelica dahurica, 90g of Lithospermum officinale, and 100g of Radix Bletillae into a coarse powder, add the coarse powder to 550g of sea buckthorn oil and soak for 12h, then pour the mixture into a pot together with the soaking oil and boil the oil over high heat, then simmer over low heat until the residue turns brown, filter out the oil and set aside; Grind 4g of calamine, 60g of borneol, and 100g of red ochre into fine powder separately. Pour the ground powder into a casserole, heat and solidify it, cover the pot and seal the lid. After the water evaporates, place it on the stove and refine it for 4.5 hours. Then stop heating and scrape the powder with a pottery blade after cooling to obtain fine powder. Grind 100g of Phellodendron amurense, 120g of Sanguisorba officinalis, 80g of Rhubarb, 60g of Gallnut, 150g of Scutellaria baicalensis, 30g of Atractylodes lancea, 30g of Luffa sponge, and 30g of Catechu, and pass through a 50-mesh sieve to obtain a coarse powder; The coarse powder is then put into an ultrafine grinder for grinding and passed through a 400-mesh sieve to obtain ultrafine powder; Finally, the fine powder, ultrafine powder, 9 g of beeswax and the oil are mixed together, heated until the beeswax is melted and then fully mixed to obtain an ointment for external use on burns.

[0036] Application Examples Application Example 1 Application Example 1 provides an application of a combined burn treatment drug, comprising the following steps: Mr. Li, a 6-year-old boy, tripped over a hot water bottle while playing, resulting in burns on both legs. The local pain sensation was dulled. The skin wounds were cleaned and disinfected, and then the combined burn treatment medicine in Example 1 was applied to the wounds four times a day.

[0037] Application Example 2 Application Example 2 provides an application of a combined burn treatment drug, comprising the following steps: Yang, a 10-year-old female student, suffered a mild burn on the instep of her foot by boiling water. The skin wound was cleaned and disinfected, and then the combined burn treatment medicine in Example 2 was applied to the wound four times a day.

[0038] Application Example 3 Application Example 3 provides an application of a combined burn treatment drug, comprising the following steps: Mr. Wu, a 14-year-old male student, had his left hand scalded by boiling water. He cleaned and disinfected the skin wound, and then applied the combined scald treatment medicine in Example 3 to the wound four times a day.

[0039] Application Example 4 Application Example 4 provides an application of a combined burn treatment drug, comprising the following steps: Yang, an 18-year-old female student, suffered a mild burn on her back from boiling water. The skin wound was cleaned and disinfected, and then the combined burn treatment medicine in Example 4 was applied to the wound four times a day.

[0040] Application Example 5 Application Example 5 provides an application of a combined burn treatment drug, comprising the following steps: Mr. Li, a 23-year-old male student, had his instep scalded by boiling water, which was a mild scald. The skin wound was cleaned and disinfected, and then the combined scald treatment medicine in Example 5 was applied to the wound four times a day.

[0041] Application Example 6 Application Example 6 provides an application of a combined burn treatment drug, comprising the following steps: Zhu, a 25-year-old female student, suffered a mild burn on her calf from boiling water. The skin wound was cleaned and disinfected, and then the combined burn treatment medicine in Example 6 was applied to the wound four times a day.

[0042] Application Example 7 Application Example 7 provides an application of a combined burn treatment drug, comprising the following steps: Zhang, a 36-year-old male worker, suffered a mild burn on his arm from boiling water. He cleaned and disinfected the skin wound, and then applied the combined burn treatment medicine in Example 7 to the wound four times a day.

[0043] Application Example 8 Application Example 8 provides an application of a combined burn treatment drug, comprising the following steps: Wang, female, 42, employee, suffered a mild burn on her left hand from boiling water. She cleaned and disinfected the skin wound, and then applied the combined burn treatment medicine of Example 8 to the wound four times a day.

[0044] Comparative Application Examples Comparative Application Example 1 Comparative Application Example 1 provides an application of a topical ointment for burns, comprising the following steps: Kong, a 45-year-old female farmer, overturned a hot water bottle and scalded her left foot. She cleaned and disinfected the skin wound and applied the scald ointment in Comparative Example 1 once a day.

[0045] Performance test treatment effect: observe how many days it takes for the patients in each application example and the comparative application example to recover from burns; and during the treatment process, score the pain relief effect of the drug on a scale of 1-10, with the higher the score, the better the pain relief effect of the drug.

[0046] Table 1 Performance test results of drugs sample Healing time (days) Pain relief score Application Example 1 7 9 Application Example 2 7 9 Application Example 3 7 9 Application Example 4 7 9 Application Example 5 7 9 Application Example 6 6 9 Application Example 7 5 9 Application Example 8 5 10 Comparative Application Example 1 13 5 Combining Application Examples 1-3 and Comparative Application Example 1, it can be seen that the medicine for treating burns in this application has a simple formula. Earthworm powder is rich in active proteins and growth factors, which promote epidermal regeneration; rapeseed oil contains more linoleic acid, which enhances skin barrier repair. Therefore, the combination of earthworm powder and rapeseed oil has a better therapeutic effect on burns, a faster healing time, and a better pain relief effect.

[0047] Combining Application Example 2, Application Example 4 and Application Example 5, it can be seen that when preparing earthworm powder, controlling the particle size of the earthworm powder to 80-100 meshes can obtain a better therapeutic effect of the burn treatment medicine.

[0048] Combining Application Example 4 and Application Example 6, the efficacy of the burn treatment drug in Example 6 is better. It can be seen that when preparing the burn treatment drug, Manuka honey is added to the raw materials. The methylglyoxal in Manuka honey can target and eliminate pathogens, reduce the risk of infection, provide a clean environment for the healing effect of earthworm powder, and prolong the duration of drug action.

[0049] Combining Application Example 4 and Application Example 7, the efficacy of the scald treating medicine in Example 7 is better. It can be seen that when preparing the scald treating medicine, aloe polysaccharide and asiaticoside are added to the raw materials. Aloe polysaccharide reduces the release of inflammatory factors and reduces tissue edema, and asiaticoside stimulates collagen synthesis, accelerates wound closure, and enhances deep repair. The two work together to shorten the inflammatory period and accelerate healing.

[0050] Combining Application Example 4 and Application Example 8, the efficacy of the burn treatment drug in Example 8 is better. It can be seen that when preparing the burn treatment drug, vitamin E acetate and sodium alginate gel matrix are added to the raw materials. The sodium alginate gel matrix forms a breathable physical barrier, and rapeseed oil and vitamin E acetate construct a lipid chemical barrier. The double protection reduces external irritation, stabilizes the formula, prolongs the effectiveness of the active ingredients, further improves the efficacy of the burn treatment drug, and relieves pain.

[0051] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A combined medicament for treating burns, characterized by: The raw materials of the scald treating medicine include the following components in parts by weight: 10-20 parts of earthworm powder and 35-45 parts of rapeseed oil.

2. The combined scald treatment medicine according to claim 1, characterized in that: The preparation method of the earthworm powder comprises the following steps: Black earthworms are selected, their skins are peeled and their internal organs are removed, and then they are cleaned, disinfected and dried in the sun, ground into powder, and sieved with an 80-100 mesh filter to obtain earthworm powder.

3. The combined scald treatment medicine according to claim 1, characterized in that: The preparation method of the rapeseed oil comprises the following steps: Pretreatment: The rapeseed is passed through a vibrating screen to remove impurities such as sand and broken shells, then rinsed with clean water and dried until the moisture content is less than 8%; Oil pressing: Use a spiral cold press to press the oil, filter it, remove the large particles of oil residue, and obtain the virgin oil; Refining: The virgin oil is distilled at 160-180°C to obtain rapeseed oil.

4. The combined medicament for treating burns according to claim 1, characterized in that: The raw materials of the scald treating medicine also include 5 to 10 parts by weight of Manuka honey.

5. The combined scald treatment medicine according to claim 4, characterized in that: The raw materials of the scald treating medicine also include 5 to 8 parts by weight of aloe polysaccharide and 3 to 5 parts by weight of asiaticaside.

6. The combined medicament for treating burns according to claim 5, characterized in that: The raw materials of the burn treatment medicine also include 1 to 3 parts by weight of vitamin E acetate and 5 to 10 parts by weight of sodium alginate gel matrix.

7. The combined medicament for treating burns according to claim 6, characterized in that: The preparation method of the sodium alginate gel matrix comprises the following steps: Sodium alginate is added to water, heated in a water bath and stirred to dissolve the sodium alginate to obtain a sodium alginate solution; then citric acid buffer is added to adjust the pH of the sodium alginate solution to 6.5-7.0; finally, calcium chloride solution is added dropwise and stirred until a uniform gel is formed to obtain a sodium alginate gel matrix.

8. A method for preparing the combined scald treatment medicine according to any one of claims 1 to 7, characterized in that: The following steps are involved: The earthworm powder, rapeseed oil and other raw materials are stirred and mixed evenly to obtain a combined scald treating medicine.

9. A use of the combined scald treatment drug according to any one of claims 1 to 7, characterized in that: The following steps are involved: Clean and disinfect the skin wound, then apply the combination burn treatment medicine to the wound four to five times a day.