Aspartame synthesis process capable of realizing sustainable production and device thereof
By using split filler covers and filler tubes, heating components and mixing mechanisms in aspartame production equipment, the problems of uneven mixing of raw materials and uneven heating are solved, efficient and stable aspartame production is achieved, and product quality is improved.
Patent Information
- Application Number
- CN202510636243.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-16
- Publication Date
- 2025-08-15
AI Technical Summary
The existing aspartame production equipment is unevenly mixed and heated when the raw materials are added, resulting in low production efficiency and poor product quality.
The split-flow filler cover and filler tube are used to ensure that the raw materials are added evenly, and the heating components and agitating mechanism are used for rapid and uniform heating and stirring. The temperature is monitored in real time with the temperature measuring components, the shell group is controlled for easy maintenance, and the touch screen is simplified.
It improves the efficiency and quality of aspartame production, ensures the uniformity and stability of reactions, reduces the possibility of equipment failure, and reduces the labor intensity of operators.
Smart Images
Figure CN120484054A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of aspartame production equipment, in particular to a sustainable aspartame synthesis process and a device thereof. Background Art
[0002] In the field of modern food additive production, aspartame, as a widely used sweetener, continues to see growing market demand. The synthetic production of aspartame involves a series of complex chemical reaction processes, which place extremely high demands on the performance, stability, and precise control of reaction conditions of production equipment. Aspartame production equipment is mostly of traditional design. During the raw material addition process, a simple top-opening feeding method is usually adopted, and the raw materials are directly poured into the reaction vessel, which can easily lead to uneven distribution of the raw materials. Although some equipment has a simple stirring device, the stirring blade design is unreasonable and cannot penetrate deep into the reaction system for sufficient stirring, resulting in poor raw material mixing effect, slow and uneven reaction rate, and seriously affecting the production efficiency and product quality of aspartame.
[0003] Traditional equipment mostly uses external jacket heating, which results in inefficient and uneven heat transfer. Because the heating elements are located outside the reaction vessel, raw materials in different locations within the vessel receive varying amounts of heat, which can easily lead to overheating and decomposition of some raw materials while leaving others underheated. This makes it impossible to meet the precise temperature control requirements of the aspartame synthesis reaction, significantly limiting improvements in product quality.
[0004] Regarding the above-mentioned related technologies, it is found that the existing aspartame production efficiency is low when the single-portion synthesis method is used during processing. At the same time, it is easy to cause uneven mixing and uneven heating when adding materials, resulting in poor aspartame synthesis effect, and also greatly reducing the synthesis quality of the product. Summary of the Invention
[0005] The present invention solves the problems in the related art, proposes a sustainable production aspartame synthesis process and apparatus thereof, and solves the problems of the existing aspartame being unable to be produced continuously during processing and having low processing efficiency and quality.
[0006] In order to solve the above technical problems, the present invention is achieved through the following technical solutions: a sustainable production process for synthesizing aspartame, comprising the following steps:
[0007] S1: Add an appropriate amount of benzyloxycarbonyl-L-aspartic acid to a reaction vessel, and then add acetic anhydride and a catalyst. The molar ratio of benzyloxycarbonyl-L-aspartic acid to acetic anhydride is generally 1:1.2-1:1.5;
[0008] S2: After stirring and mixing, the reaction system is heated to 40-60°C and reacted at this temperature for 2-4 hours. During the reaction, benzyloxycarbonyl-L-aspartic acid undergoes a cyclization reaction to form benzyloxycarbonyl-L-aspartic anhydride;
[0009] S3: After the reaction is completed, the reaction mixture is cooled to room temperature, and then an appropriate amount of organic solvent is added for extraction to separate benzyloxycarbonyl-L-aspartic anhydride. The organic phase is dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by distillation under reduced pressure to obtain crude benzyloxycarbonyl-L-aspartic anhydride.
[0010] S4: dissolving the benzyloxycarbonyl-L-aspartic anhydride obtained in S3 in an appropriate amount of an organic solvent, then adding L-phenylalanine methyl ester hydrochloride, and then adding an appropriate amount of an alkaline reagent to the reaction system to neutralize the hydrochloric acid in the L-phenylalanine methyl ester hydrochloride;
[0011] S5: stirring and reacting at room temperature for 6-10 hours, during which the benzyloxycarbonyl-L-aspartic anhydride and L-phenylalanine methyl ester undergo a condensation reaction to form benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester;
[0012] S6: After the reaction is completed, an appropriate amount of water is added to the reaction mixture, followed by extraction with an organic solvent. The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by vacuum distillation to obtain benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0013] S7: dissolving benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester in an appropriate amount of organic solvent, and adding an appropriate amount of catalyst;
[0014] S8: Placing the reaction system in a hydrogen atmosphere and performing a catalytic hydrogenation reaction at room temperature and pressure. During the reaction, the benzyloxycarbonyl protecting group is removed by hydrogenolysis to produce aspartame;
[0015] S9: After the reaction is completed, the catalyst is removed by filtration, and the filtrate is distilled under reduced pressure to remove the organic solvent to obtain crude aspartame;
[0016] S10: using a water-ethanol mixed solvent or a water-methanol mixed solvent as a recrystallization solvent, and refining the aspartame by recrystallization to obtain a white powder aspartame with a purity of more than 99%.
[0017] As a preferred solution, the catalyst in S1 is pyridine, and the amount of pyridine used is 0.1-0.2 times the molar amount of benzyloxycarbonyl-L-aspartic acid.
[0018] As a preferred embodiment, the molar ratio of L-phenylalanine methyl ester hydrochloride to benzyloxycarbonyl-L-aspartic anhydride in S4 is generally 1:1-1:1.1, and the amount of the alkaline reagent is 1-1.2 times the molar amount of L-phenylalanine methyl ester hydrochloride.
[0019] As a preferred solution, the catalyst in S7 is a palladium-carbon catalyst, and the amount of the catalyst used is generally 5% to 10% of the mass of benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0020] A production device includes an equipment seat, which includes a seat box and a bracket. The bracket is symmetrically mounted on the upper end surface of the seat box, and the bracket is fixedly connected to the seat box. A processing box is mounted on the upper end surface of the bracket, and the processing box is fixedly connected to the bracket. A control shell group is provided in the middle of the seat box, and the control shell group is detachably fixedly connected to the seat box. A heating component and a stirring mechanism extending into the interior of the processing box are also installed on the upper end surface of the seat box. The heating component and the stirring mechanism are both fixedly connected to the seat box. A diverter filler cover is also fixedly mounted on the upper end surface of the processing box, and a plurality of filler tubes are evenly arranged on the upper end surface of the diverter filler cover.
[0021] As a preferred solution, a central groove for installing the control shell group is opened in the middle of the seat box, and a number of rubber feet are evenly installed on the lower end surface of the seat box in the circumferential direction. The rubber feet are fixedly connected to the seat box. An auxiliary shaft seat is also installed at the center of the upper end surface of the seat box. The auxiliary shaft seat and the seat box are integrally formed. A positioning plate is also fixedly installed on the upper end surface of the seat box. A number of temperature measuring components of different heights are vertically installed on the upper end surface of the positioning plate. The head of the temperature measuring component extends into the processing box.
[0022] As a preferred solution, the processing box includes a box seat, a main box shell and an edge plate. The box seat is installed on the upper end face of the bracket, and the box seat is fixedly connected to the bracket by bolts. The main box shell is installed on the upper end face of the box seat, and the main box shell and the box seat are sealed and fixedly connected. The edge plate is coaxially installed on the upper end face of the main box shell, and the edge plate and the main box shell are integrally formed.
[0023] As a preferred solution, the control shell group includes an outer frame shell, a controller and a touch screen connected to the controller. The outer frame shell is plugged into the center groove of the seat box, and the outer frame shell is fixed to the seat box. The controller is fixedly connected to the outer frame shell, and the touch screen is fixedly installed on the outer surface of the outer frame shell.
[0024] As a preferred solution, the heating assembly includes a middle seat and an electric heating tube. The middle seat is fixedly mounted on the upper end surface of the auxiliary shaft seat. The electric heating tube is symmetrically mounted on both sides of the middle seat and is fixedly connected to the middle seat.
[0025] As a preferred solution, the stirring mechanism includes a drive motor, a vertical rod and a stirring impeller. The drive motor is fixedly installed in the central groove of the seat box. The lower end of the vertical rod is connected to the output end of the drive motor, and the head of the vertical rod passes through the auxiliary shaft seat and the middle seat in turn and extends into the main box shell. The stirring impeller is sleeved and fixed on the head of the vertical rod.
[0026] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention can heat and stir the raw materials quickly and evenly through the reasonable arrangement of the heating component and the stirring mechanism, promote the progress of the chemical reaction, and greatly improve the production efficiency of aspartame. The diverter filler cap and the filler tube allow the raw materials to be added evenly, the temperature measuring component monitors the temperature in real time, and the stirring mechanism stirs thoroughly. These measures ensure the uniformity and stability of the reaction, which helps to improve the product quality of aspartame. The detachable design of the control shell group and the setting of the touch screen facilitate the operation and maintenance of the equipment. When the equipment fails, the control shell group can be disassembled in time for inspection and maintenance. The operating interface of the touch screen is simple and intuitive, which reduces the labor intensity of the operator. The shock-absorbing and anti-slip effect of the rubber feet, the firm connection of the various components, and the sealing design of the processing box enhance the stability and safety of the equipment and reduce the possibility of failures and accidents during the operation of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS
[0027] Figure 1 It is a schematic diagram of the overall structure of the present invention;
[0028] Figure 2 yes Figure 1 a front view of the device shown;
[0029] Figure 3 It is a three-dimensional structure in which the equipment base, heating component and stirring mechanism in the embodiment of the present invention cooperate with each other;
[0030] Figure 4 yes Figure 3 a front view of the device shown;
[0031] Figure 5 yes Figure 3 a side view of the device shown;
[0032] Figure 6 yes Figure 3 a top view of the device shown;
[0033] Figure 7 is a three-dimensional diagram of a control housing assembly according to an embodiment of the present invention;
[0034] Figure 8 yes Figure 7 Top view of the device shown.
[0035] In the figure: 1. Equipment seat; 11. Seat box; 111. Center groove; 112. Rubber pads; 113. Auxiliary shaft seat; 12. Bracket; 13. Positioning plate; 131. Temperature measuring component; 2. Processing box; 21. Box seat; 22. Main box shell; 23. Edge plate; 3. Control shell group; 31. Outer frame shell; 32. Controller; 33. Touch screen; 4. Heating component; 41. Middle seat; 42. Electric heating tube; 5. Stirring mechanism; 51. Drive motor; 52. Vertical rod; 53. Stirring impeller; 6. Diverter stuffing cover; 61. Stuffing tube. DETAILED DESCRIPTION
[0036] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, rather than all the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is in no way intended to limit the present invention and its application or use. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0037] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, operations, devices, components and / or combinations thereof.
[0038] Unless otherwise specifically stated, the relative arrangement of the parts and steps, the numerical expressions and the numerical values set forth in these embodiments do not limit the scope of the present invention. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to the actual proportional relationship. The techniques, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods and equipment should be considered as part of the authorization specification. In all examples shown and discussed here, any specific values should be interpreted as being merely exemplary and not as limiting. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.
[0039] In the description of the present invention, it should be understood that the directions or positional relationships indicated by directional words such as "front, back, up, down, left, right", "horizontal, vertical, perpendicular, horizontal" and "top, bottom" are usually based on the directions or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description. Unless otherwise specified, these directional words do not indicate or imply that the device or element referred to must have a specific direction or be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the scope of protection of the present invention; the directional words "inside and outside" refer to the inside and outside relative to the outline of each component itself.
[0040] For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used herein to describe the spatial positional relationship of a device or feature to other devices or features as shown in the figures. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figures. For example, if the device in the drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" can include both "above" and "below". The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatially relative descriptions used here are interpreted accordingly.
[0041] In addition, it should be noted that the use of words such as "first" and "second" to limit components is only for the convenience of distinguishing the corresponding components. Unless otherwise stated, the above words have no special meaning and therefore cannot be understood as limiting the scope of protection of the present invention.
[0042] A sustainable aspartame synthesis process is disclosed, wherein aspartame is synthesized by the benzyloxycarbonyl-L-aspartic anhydride method, and mainly comprises the following steps:
[0043] First, prepare benzyloxycarbonyl-L-aspartic anhydride:
[0044] An appropriate amount of benzyloxycarbonyl-L-aspartic acid is added to a reaction vessel, followed by acetic anhydride and pyridine. The molar ratio of benzyloxycarbonyl-L-aspartic acid to acetic anhydride is typically 1:1.2-1:1.5. Pyridine is used as a catalyst, typically in an amount of 0.1-0.2 times the molar amount of benzyloxycarbonyl-L-aspartic acid.
[0045] After stirring and mixing, the reaction system is heated to 40-60°C and reacted at this temperature for 2-4 hours. During the reaction, benzyloxycarbonyl-L-aspartic acid undergoes a cyclization reaction to generate benzyloxycarbonyl-L-aspartic anhydride.
[0046] After the reaction is completed, the reaction mixture is cooled to room temperature, and then an appropriate amount of an organic solvent (e.g., dichloromethane) is added for extraction to isolate benzyloxycarbonyl-L-aspartic anhydride. The organic phase is dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by distillation under reduced pressure to obtain crude benzyloxycarbonyl-L-aspartic anhydride.
[0047] To improve the purity of the product, the crude product can be recrystallized, and a commonly used recrystallization solvent is an ethanol-water mixture. After recrystallization, benzyloxycarbonyl-L-aspartic anhydride is obtained as white crystals with a purity of more than 98%.
[0048] Secondly, the preparation of benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester was carried out:
[0049] Dissolve the benzyloxycarbonyl-L-aspartic anhydride obtained in the previous step in an appropriate amount of an organic solvent (such as dichloromethane or N,N-dimethylformamide), and then add L-phenylalanine methyl ester hydrochloride. The molar ratio of L-phenylalanine methyl ester hydrochloride to benzyloxycarbonyl-L-aspartic anhydride is generally 1:1 to 1:1.1.
[0050] Add an appropriate amount of alkaline reagent (such as triethylamine or sodium carbonate) to the reaction system to neutralize the hydrochloric acid in L-phenylalanine methyl ester hydrochloride so that the reaction can proceed smoothly. The amount of alkaline reagent used is usually 1-1.2 times the molar amount of L-phenylalanine methyl ester hydrochloride.
[0051] The reaction is stirred at room temperature for 6-10 hours. During the reaction, benzyloxycarbonyl-L-aspartic anhydride and L-phenylalanine methyl ester undergo condensation reaction to generate benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0052] After the reaction is completed, an appropriate amount of water is added to the reaction mixture, followed by extraction with an organic solvent (e.g., dichloromethane). The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by distillation under reduced pressure to obtain crude benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0053] The crude product can be further purified by column chromatography or the like to obtain high-purity benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0054] Finally, the preparation of aspartame is carried out:
[0055] Benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester is dissolved in an appropriate amount of an organic solvent (such as methanol or ethanol), and an appropriate amount of a catalyst (such as a palladium-carbon catalyst) is added. The amount of the catalyst used is generally 5% to 10% of the mass of the benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
[0056] The reaction system is placed in a hydrogen atmosphere and a catalytic hydrogenation reaction is carried out at room temperature and pressure or at an appropriate pressure (e.g., 1-3 atm). During the reaction, the benzyloxycarbonyl protecting group is removed by hydrogenolysis to produce aspartame.
[0057] After the reaction is completed, the catalyst is removed by filtration, and the filtrate is then distilled under reduced pressure to remove the organic solvent to obtain crude aspartame.
[0058] Crude aspartame can be refined by recrystallization and other methods. Commonly used recrystallization solvents are water-ethanol mixed solvents or water-methanol mixed solvents. After recrystallization, aspartame is obtained as a white powder with a purity of over 99%.
[0059] Example 1
[0060] Reference Figure 1 、 Figure 2 、 Figure 3 and Figure 4 As shown, a production device includes an equipment base 1, which includes a base box 11 and a bracket 12. The bracket 12 is symmetrically mounted on the upper end surface of the base box 11 and is fixedly connected to the base box 11. The upper end surface of the bracket 12 is mounted with a processing box 2, which is fixedly connected to the bracket 12. A control shell group 3 is provided in the middle of the base box 11, and the control shell group 3 is detachably fixedly connected to the base box 11. The upper end surface of the base box 11 is also mounted with a heating component 4 and a stirring mechanism 5 extending into the interior of the processing box 2. The heating component 4 and the stirring mechanism 5 are both fixedly connected to the base box 11. The upper end surface of the processing box 2 is also fixedly mounted with a diverter filler cover 6, and the upper end surface of the diverter filler cover 6 is evenly provided with a plurality of filler tubes 61. When the sustainable aspartame production device proposed in the present invention is in use, the equipment base 1 provides a stable support base for the entire device. The symmetrical installation of the bracket 12 ensures the stability of the installation of the processing box 2, making the processing process more stable. The detachable fixed connection of the control shell group 3 facilitates the maintenance and inspection of the equipment. When the control shell group 3 fails, it can be disassembled and replaced in time. The heating component 4 and the stirring mechanism 5 extend into the interior of the processing box 2, and can directly heat and stir the raw materials in the processing box 2, promote the progress of the chemical reaction, and improve production efficiency. The setting of the diverter filling cover 6 and the filling pipe 61 allows the raw materials to be evenly added to the processing box 2, avoiding the accumulation of raw materials and ensuring the uniformity of the reaction. After one group of quantitative production is completed, it can be discharged through the discharge pipe set on the side. After the discharge is completed, the quantitative filling can be continued from the filling pipe 61 on the upper end face of the diverter filling cover 6 at the upper end for continuous processing.
[0061] Reference Figure 4 、 Figure 5 and Figure 6As shown, a central groove 111 for installing the control housing group 3 is provided in the middle of the seat box 11, and a number of rubber feet 112 are evenly installed along the circumferential direction on the lower end surface of the seat box 11. The rubber feet 112 are fixedly connected to the seat box 11. An auxiliary shaft seat 113 is also installed at the center of the upper end surface of the seat box 11. The auxiliary shaft seat 113 and the seat box 11 are integrally formed. A positioning plate 13 is also fixedly installed on the upper end surface of the seat box 11. A number of temperature measuring components 131 of different heights are vertically installed on the upper end surface of the positioning plate 13. The heads of the temperature measuring components 131 extend into the processing box 2. The central groove 111 provided in the middle of the seat box 11 provides a specific space for the installation of the control housing group 3, ensuring the accuracy and stability of the installation of the control housing group 3. The installation of the rubber feet 112 can play a role in shock absorption and anti-slip, reducing the vibration and noise generated by the equipment during operation, while preventing the equipment from sliding, thereby improving the safety of the equipment. The auxiliary shaft seat 113 is integrally formed with the housing 11, enhancing the structural strength and stability and providing reliable support for the installation of the heating assembly 4 and the stirring mechanism 5. Several temperature measuring assemblies 131 at different heights mounted on the positioning plate 13 can monitor the temperature at different heights within the processing chamber 2 in real time, providing accurate data for temperature control during the production process and helping to ensure product quality.
[0062] Reference Figure 1 and Figure 2 As shown, the processing box 2 includes a box base 21, a main box shell 22, and an edge plate 23. The box base 21 is mounted on the upper end surface of the bracket 12 and is fixedly connected to the bracket 12 by bolts. The main box shell 22 is mounted on the upper end surface of the box base 21 and is sealed and fixedly connected to the box base 21. The edge plate 23 is coaxially mounted on the upper end surface of the main box shell 22 and is integrally formed with the main box shell 22. The processing box 2 adopts a structural design of the box base 21, the main box shell 22, and the edge plate 23. The box base 21 is fixedly connected to the bracket 12 by bolts, which facilitates the installation and removal of the processing box 2 while ensuring the firmness of the connection. The main box shell 22 is sealed and fixedly connected to the box base 21 to prevent raw material leakage and ensure the safety and hygiene of the production process. The edge plate 23 is integrally formed with the main box shell 22, enhancing the structural strength of the main box shell 22 and providing a suitable position for the installation of the diverter packing cover 6.
[0063] Reference Figure 7 and Figure 8As shown, the control housing assembly 3 includes an outer frame housing 31, a controller 32, and a touch screen 33 connected to the controller 32. The outer frame housing 31 is plugged into the center groove 111 of the seat box 11 and is fixedly engaged with the seat box 11. The controller 32 is fixedly connected to the outer frame housing 31, and the touch screen 33 is fixedly mounted on the outer surface of the outer frame housing 31. The outer frame housing 31 of the control housing assembly 3 is plugged into the center groove 111 of the seat box 11 and fixedly engaged. This installation method is simple and convenient, and facilitates the removal and replacement of the control housing assembly 3. The controller 32 is fixed in the outer frame housing 31, which can accurately control the operation of the entire production device. The touch screen 33 is fixedly mounted on the outer surface of the outer frame housing 31, making it convenient for operators to operate and monitor, thereby improving the intelligence level of the equipment and the convenience of operation.
[0064] Example 2
[0065] Reference Figure 1 、 Figure 3 and Figure 4 As shown, a production device includes an equipment seat 1, which includes a seat box 11 and a bracket 12. The bracket 12 is symmetrically installed on the upper end surface of the seat box 11, and the bracket 12 is fixedly connected to the seat box 11. A processing box 2 is installed on the upper end surface of the bracket 12, and the processing box 2 is fixedly connected to the bracket 12. A control shell group 3 is provided in the middle of the seat box 11, and the control shell group 3 is detachably fixedly connected to the seat box 11. The upper end surface of the seat box 11 is also installed with a heating component 4 and a stirring mechanism 5 extending into the interior of the processing box 2, and the heating component 4 and the stirring mechanism 5 are both fixedly connected to the seat box 11.
[0066] Reference Figure 3 and Figure 4 As shown, heating assembly 4 includes a center base 41 and electric heating tubes 42. Center base 41 is fixedly mounted on the upper end surface of auxiliary shaft base 113, and electric heating tubes 42 are symmetrically mounted on either side of center base 41. Electric heating tubes 42 are fixedly connected to center base 41. Center base 41 of heating assembly 4 is fixedly mounted on the upper end surface of auxiliary shaft base 113, ensuring the stability of heating assembly 4. The electric heating tubes 42 are symmetrically mounted on either side of center base 41, evenly heating the raw materials in processing box 2. This ensures more uniform heating of the raw materials, improves heating efficiency, and helps promote the chemical reaction.
[0067] Reference Figure 3 and Figure 4As shown, the stirring mechanism 5 includes a driving motor 51, a vertical rod 52 and a stirring impeller 53. The driving motor 51 is fixedly mounted in the center groove 111 of the housing 11. The lower end of the vertical rod 52 is connected to the output terminal of the driving motor 51, and the head of the vertical rod 52 passes through the auxiliary shaft seat 113 and the middle seat 41 in sequence and extends into the main housing 22. The stirring impeller 53 is sleeved and fixed on the head of the vertical rod 52. The driving motor 51 of the stirring mechanism 5 is fixedly mounted in the center groove 111 of the housing 11, providing a stable power source for stirring. The lower end of the vertical rod 52 is connected to the output terminal of the driving motor 51, and the head passes through the auxiliary shaft seat 113 and the middle seat 41 in sequence and extends into the main housing 22, ensuring the stability and accuracy of stirring. The stirring impeller 53 is sleeved and fixed on the head of the vertical rod 52, and can fully stir the raw materials in the processing box 2, so that the raw materials are mixed more evenly, thereby improving the reaction rate and product quality.
[0068] Working Principle: During operation, the equipment base serves as the support foundation for the entire unit. Raw materials are evenly and quantitatively added to the process tank via the diverter filler cap and filler tube. A heating assembly and stirring mechanism extend deep into the process tank, heating and stirring the raw materials, promoting the chemical reactions involved in aspartame synthesis. After a batch of production is completed, the product is discharged from a side discharge pipe and then fed back through the filler tube for continuous processing. A controller within the control housing precisely controls the entire unit, while a touchscreen on the exterior facilitates operator monitoring and operation. When the control housing requires installation or maintenance, it is pulled out of the center slot, allowing for easy removal, inspection, and replacement of any faulty controllers.
[0069] Several temperature-measuring components, mounted at varying heights on the positioning plate on the upper end of the housing, extend into the processing chamber to monitor temperatures at various locations within the chamber in real time. This provides data support for precise temperature control during the production process and ensures product quality. The heating components' electric heating tubes uniformly heat the raw materials within the chamber, ensuring uniform heating, improving heating efficiency, and accelerating the chemical reaction process. The stirring mechanism's drive motor, via a vertical rod, rapidly rotates the impeller at the head, ensuring thorough mixing of the raw materials, enhancing reaction efficiency and product quality.
[0070] The above are preferred embodiments of the present invention. Those skilled in the art to which the present invention belongs can also change and modify the above embodiments. Therefore, the present invention is not limited to the above specific embodiments. Any obvious improvements, replacements or modifications made by those skilled in the art on the basis of the present invention fall within the scope of protection of the present invention.
Claims
1. A sustainable aspartame synthesis process, characterized in that: The steps include: S1: Add an appropriate amount of benzyloxycarbonyl-L-aspartic acid to a reaction vessel, and then add acetic anhydride and a catalyst. The molar ratio of benzyloxycarbonyl-L-aspartic acid to acetic anhydride is generally 1:1.2-1:1.5; S2: After stirring and mixing, the reaction system is heated to 40-60°C and reacted at this temperature for 2-4 hours. During the reaction, benzyloxycarbonyl-L-aspartic acid undergoes a cyclization reaction to form benzyloxycarbonyl-L-aspartic anhydride; S3: After the reaction is completed, the reaction mixture is cooled to room temperature, and then an appropriate amount of organic solvent is added for extraction to separate benzyloxycarbonyl-L-aspartic anhydride. The organic phase is dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by distillation under reduced pressure to obtain crude benzyloxycarbonyl-L-aspartic anhydride. S4: dissolving the benzyloxycarbonyl-L-aspartic anhydride obtained in S3 in an appropriate amount of an organic solvent, then adding L-phenylalanine methyl ester hydrochloride, and then adding an appropriate amount of an alkaline reagent to the reaction system to neutralize the hydrochloric acid in the L-phenylalanine methyl ester hydrochloride; S5: stirring and reacting at room temperature for 6-10 hours, during which the benzyloxycarbonyl-L-aspartic anhydride and L-phenylalanine methyl ester undergo a condensation reaction to form benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester; S6: After the reaction is completed, an appropriate amount of water is added to the reaction mixture, followed by extraction with an organic solvent. The organic phase is washed with water, dried over anhydrous sodium sulfate, filtered to remove the desiccant, and then the organic solvent is removed by vacuum distillation to obtain benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester. S7: dissolving benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester in an appropriate amount of organic solvent, and adding an appropriate amount of catalyst; S8: Placing the reaction system in a hydrogen atmosphere and performing a catalytic hydrogenation reaction at room temperature and pressure. During the reaction, the benzyloxycarbonyl protecting group is removed by hydrogenolysis to produce aspartame; S9: After the reaction is completed, the catalyst is removed by filtration, and the filtrate is distilled under reduced pressure to remove the organic solvent to obtain crude aspartame; S10: using a water-ethanol mixed solvent or a water-methanol mixed solvent as a recrystallization solvent, and refining the aspartame by recrystallization to obtain a white powder aspartame with a purity of more than 99%.
2. A sustainable aspartame synthesis process according to claim 1, characterized in that: The catalyst in S1 is pyridine, and the amount of pyridine used is 0.1-0.2 times the molar amount of benzyloxycarbonyl-L-aspartic acid.
3. A sustainable aspartame synthesis process according to claim 2, characterized in that: The molar ratio of L-phenylalanine methyl ester hydrochloride to benzyloxycarbonyl-L-aspartic anhydride in S4 is generally 1:1-1:1.1, and the amount of the alkaline reagent used is 1-1.2 times the molar amount of L-phenylalanine methyl ester hydrochloride.
4. A sustainable aspartame synthesis process according to claim 3, characterized in that: The catalyst in S7 is a palladium-carbon catalyst, and the amount of the catalyst used is generally 5% to 10% of the mass of benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester.
5. A production device for a sustainable aspartame synthesis process according to any one of claims 1 to 4, comprising an equipment base (1), characterized in that: The equipment seat (1) includes a seat box (11) and a bracket (12), wherein the bracket (12) is symmetrically mounted on the upper end surface of the seat box (11), and the bracket (12) is fixedly connected to the seat box (11), and a processing box (2) is mounted on the upper end surface of the bracket (12), and the processing box (2) is fixedly connected to the bracket (12), and a control shell group (3) is arranged in the middle of the seat box (11), and the control shell group (3) is detachably fixedly connected to the seat box (11), and a heating component (4) and a stirring mechanism (5) extending into the interior of the processing box (2) are also mounted on the upper end surface of the seat box (11), and the heating component (4) and the stirring mechanism (5) are both fixedly connected to the seat box (11), and a diversion filling cover (6) is also fixedly mounted on the upper end surface of the processing box (2), and a plurality of filling tubes (61) are evenly arranged on the upper end surface of the diversion filling cover (6).
6. A production device according to claim 5, characterized in that: A central groove (111) for installing the control shell group (3) is provided in the middle of the seat box (11), and a plurality of rubber pads (112) are evenly installed on the lower end surface of the seat box (11) along the circumferential direction, and the rubber pads (112) are fixedly connected to the seat box (11). An auxiliary shaft seat (113) is also installed at the center of the upper end surface of the seat box (11), and the auxiliary shaft seat (113) and the seat box (11) are integrally formed. A positioning plate (13) is also fixedly installed on the upper end surface of the seat box (11), and a plurality of temperature measuring components (131) of different heights are vertically installed on the upper end surface of the positioning plate (13), and the head of the temperature measuring component (131) extends into the processing box (2).
7. A production device according to claim 6, characterized in that: The processing box (2) comprises a box seat (21), a main box shell (22) and an edge plate (23); the box seat (21) is mounted on the upper end surface of the bracket (12), and the box seat (21) is fixedly connected to the bracket (12) by bolts; the main box shell (22) is mounted on the upper end surface of the box seat (21), and the main box shell (22) and the box seat (21) are sealed and fixedly connected; the edge plate (23) is coaxially mounted on the upper end surface of the main box shell (22), and the edge plate (23) and the main box shell (22) are integrally formed.
8. A production device according to claim 7, characterized in that: The control shell group (3) includes an outer frame shell (31), a controller (32) and a touch screen (33) connected to the controller (32); the outer frame shell (31) is plugged into a central groove (111) of the seat box (11), and the outer frame shell (31) is fixedly engaged with the seat box (11); the controller (32) is fixedly connected to the outer frame shell (31); and the touch screen (33) is fixedly installed on the outer surface of the outer frame shell (31).
9. A production device according to claim 8, characterized in that: The heating assembly (4) includes a middle seat (41) and an electric heating tube (42), wherein the middle seat (41) is fixedly mounted on the upper end surface of the auxiliary shaft seat (113), and the electric heating tube (42) is symmetrically mounted on both sides of the middle seat (41), and the electric heating tube (42) is fixedly connected to the middle seat (41).
10. A production device according to claim 9, characterized in that: The stirring mechanism (5) comprises a driving motor (51), a vertical rod (52) and a stirring impeller (53). The driving motor (51) is fixedly mounted in the central groove (111) of the seat box (11). The lower end of the vertical rod (52) is connected to the output end of the driving motor (51). The head of the vertical rod (52) sequentially passes through the auxiliary shaft seat (113) and the middle seat (41) and extends into the main box shell (22). The stirring impeller (53) is sleeved and fixed on the head of the vertical rod (52).