Application of ethyl pyruvate in preparing drugs for treating or preventing methamphetamine addiction

By targeting and regulating the HMGB1-TLR4-MyD88-PI3K-AKT-NF-KB signaling pathway, ethyl pyruvate significantly reduces addictive behavior and neural damage in the preparation of drugs for treating methamphetamine addiction, providing a new treatment strategy with obvious neuroprotective and repair effects.

CN120501734BActive Publication Date: 2025-09-30NINGBO KANGNING HOSPITAL (NINGBO MENTAL DISEASE PREVENTION & CONTROL CENT NINGBO INST OF MICROCIRCULATION & HYOSCYAMS)
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Patent Information

Application Number
CN202511007071.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-07-22
Publication Date
2025-09-30
Estimated Expiration
2045-07-22

AI Technical Summary

Technical Problem

Existing methods for treating methamphetamine addiction have limited effects in alleviating addiction and neural damage, and it is difficult to fundamentally improve addictive behavior.

Method used

Ethyl pyruvate (EP) was used to inhibit neuroinflammatory response and reduce methamphetamine-induced addictive behavior and neural damage by targeting the HMGB1-TLR4-MyD88-PI3K-AKT-NF-KB signaling pathway.

Benefits of technology

It significantly reduces the addictive behavior and neural damage caused by methamphetamine, promotes neural repair, and provides a new treatment strategy for methamphetamine addiction with broad clinical application prospects.

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Abstract

The present invention discloses the use of ethyl pyruvate in the preparation of a drug for treating or preventing methamphetamine addiction. The present invention belongs to the field of pharmaceutical technology and provides the use of ethyl pyruvate in the preparation of a drug for treating or preventing methamphetamine addiction. Ethyl pyruvate inhibits the HMGB1-TLR4-MyD88-PI3K-AKT-NF-KB signaling pathway, reduces neuroinflammatory responses, and significantly reduces addictive behaviors and nerve damage caused by methamphetamine. This provides a new therapeutic strategy for the treatment of methamphetamine addiction and has broad clinical application prospects. Ethyl pyruvate has significant neuroprotective effects, can reduce nerve damage, and promote nerve repair.
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