Pharmaceutical composition for treating atopic dermatitis as well as preparation method and application thereof

By topically using inactivated spherical Malassezi cream, the existing problem of inability to restore the skin microbial barrier of atopic dermatitis was solved, and safe and efficient skin inflammation relief and bacterial regulation were achieved.

CN120501770APending Publication Date: 2025-08-19PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)
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Patent Information

Application Number
CN202510720284.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-30
Publication Date
2025-08-19

AI Technical Summary

Technical Problem

Existing drugs for treating atopic dermatitis cannot effectively restore the skin microbial barrier, resulting in adverse reactions and drug resistance problems for long-term use, and lack of targeted treatments for skin flora disorders.

Method used

The topical cream with inactivated spherical Malassezia as the main ingredient is used to significantly inhibit the growth of Staphylococcus aureus by supplementing skin symbiotic bacteria, alleviating the inflammatory response, and restoring the skin barrier function.

Benefits of technology

Significantly alleviates inflammatory reactions, reduces stratum corneum thickness, reduces inflammatory cell infiltration, reduces the expression of proinflammatory factors, is highly safe, and reduces the adverse reactions caused by long-term use of traditional drugs.

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Abstract

The invention discloses a medicine composition for treating atopic dermatitis, a preparation method and application, the medicine composition comprises inactivated malassezia sphaeroides, and the strain preservation number of the malassezia sphaeroides is ATCC 96807. The cream composition disclosed by the invention is externally applied to local treatment of skin lesions of specific dermatitis, supplements skin symbiotic bacteria, assists in recovering skin barriers of patients, remarkably inhibits growth and proliferation of staphylococcus aureus at the skin lesions of dermatitis and exocrine toxins, remarkably relieves inflammatory response, reduces the thickness of cuticles and reduces inflammatory cell infiltration; the traditional Chinese medicine composition assists the treatment of atopic dermatitis through the effects of the proinflammatory factors and the expression and secretion of the proinflammatory factors, has a remarkable treatment effect on the atopic dermatitis, is quick to take effect, small in toxic and side effects and good in safety, and has a good medicinal prospect.
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