Genotype F mumps attenuated live vaccine production configuration device

Abstract

The invention discloses a genotype F mumps attenuated live vaccine production configuration, which belongs to the related technical field of vaccine production, and comprises a bracket, a premix unit and a configuration unit, the support has corresponding supporting force, and a supporting table is arranged on one side of the top end of the support and used for supporting the premixing unit. The premixing unit is configured on the supporting table, is communicated with the configuration unit through a connecting structure, and can inject a premix into the configuration unit; the preparation unit is arranged on the support and provided with a preparation shell, the preparation shell comprises an interlayer on the outer side and an inner layer on the inner side of the interlayer, the connecting unit is communicated with the inner layer, and an annular liquid distributor is arranged at the bottom of the inner layer and used for distributing liquid from the bottom. The virus liquid is uniformly distributed into the mixing shell as much as possible and is stirred at different distances through the long blades and the short blades of the stirrer, so that a stirring vortex is formed, and the stirring uniformity is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field related to vaccine production, and in particular relates to a production and configuration device for an F genotype mumps live attenuated vaccine. Background Art

[0002] Genotype F mumps live attenuated vaccine is produced by inoculating an attenuated strain of mumps virus (such as the S79 strain) into chicken embryo cell cultures. It stimulates immunity against the mumps virus and is primarily used to prevent epidemic mumps. Genotype F mumps live attenuated vaccine consists primarily of an attenuated mumps virus strain supplemented with stabilizers such as gelatin and sucrose, and is freeze-dried.

[0003] During preparation, the corresponding virus liquids are harvested, combined, and stabilizers (such as sucrose and gelatin) are added. A freeze-drying process is used to create a vaccine stock solution, which is then packaged into semi-finished and finished products. During this process, the stabilizer needs to be slowly added to the virus liquid and continuously stirred at low temperatures. Existing mixing devices use magnetic force or low-speed stirring to achieve mixing, but the mixing effect needs to be improved. Summary of the Invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a production and configuration device for an F genotype mumps live attenuated vaccine.

[0005] The technical solution adopted by the present invention is as follows: a production and configuration device for an F genotype mumps live attenuated vaccine, comprising a bracket, a premix unit and a configuration unit; the bracket has corresponding supporting force, and a support platform is configured on one side of the top, and the support platform is used to support the premix unit; the premix unit is configured on the support platform, and is connected to the configuration unit through a connecting structure, and the premix can be injected into the configuration unit; the configuration unit is configured on the bracket, and has a configuration shell, and the configuration shell includes an outer interlayer and an inner layer inside the interlayer, the connecting unit is connected to the inner layer, and the bottom of the inner layer is configured with an annular liquid distributor for distributing liquid from the bottom.

[0006] Furthermore, the configuration unit includes a stirring mechanism configured in the inner layer, the stirring mechanism includes a driving shaft and an agitator configured on the driving shaft, the driving shaft is rotatably configured at the top of the inner layer through a bearing, the top end of the driving shaft extends out of the top end of the inner layer and is connected to a rotation drive, and multiple agitators are arranged along the length direction of the driving shaft.

[0007] Furthermore, the premix unit includes a feed hopper and a premix shell connected to the feed hopper, and the feed hopper and the premix shell are arranged on a fixed frame of the support platform from top to bottom. A stirring member is rotatably arranged inside the premix unit, and a connection port connected to the connection structure is opened on the lower part of the side wall of the premix shell of the stirring member.

[0008] Furthermore, the bottom of the inner layer is connected to a liquid outlet pipe, which passes through the corresponding position of the interlayer and extends to a predetermined length below the configuration shell. The liquid distributor is an annular hollow setting with a liquid distribution port on the side wall. The bottom of the liquid distributor is connected to a liquid inlet pipe, which passes through the liquid outlet pipe and is located in the liquid outlet pipe. The part is fixed to the inner wall of the liquid outlet pipe by a fixing part. One end of the liquid inlet pipe passes through the side of the liquid outlet pipe and is provided with a valve. The end of the liquid outlet pipe is provided with a valve.

[0009] Furthermore, the upper portion and the lower portion of the interlayer side wall are connected to an inlet and an outlet respectively.

[0010] Furthermore, the connection structure includes a slide and a connecting pipe, the slide is connected to the connecting port, the connecting pipe is connected to the inner layer, the slide is equipped with a baffle plate, and the baffle plate is connected to a telescopic drive and can slide in and out of the slide for opening and closing the slide.

[0011] Furthermore, the top end of the inner layer extends out of the interlayer and is provided with an upper cover via bolts, and a liquid level sensor and a temperature sensor are provided inside the inner layer for detecting the liquid level and temperature in the inner layer.

[0012] Furthermore, the agitator includes a mounting plate, which is arranged on the drive shaft and is disc-shaped; short blades and long blades are arranged at intervals on the peripheral wall of the mounting plate, and the short blades and long blades are arranged in a ring-shaped manner around the central axis of the mounting plate.

[0013] After adopting the above structure, the beneficial effects of the present invention are as follows:

[0014] (1) Premixing the stabilizer and other auxiliary materials through the premixing unit, and opening and closing the slideway by the baffle to release the premix in a controlled manner;

[0015] (2) Through the provided agitator and liquid distributor, on the basis of premixing the premix, the virus liquid is distributed as evenly as possible into the mixing shell and stirred at different distances by the long and short blades of the agitator to form a stirring vortex and improve the uniformity of the stirring. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention.

[0017] Figure 1 This is a schematic diagram of the overall structure of a production and configuration device for a live attenuated F genotype mumps vaccine proposed in the present invention;

[0018] Figure 2 This is a schematic diagram of the premix shell structure of a production and configuration device for a live attenuated F genotype mumps vaccine proposed by the present invention;

[0019] Figure 3 This is a schematic diagram of the configuration unit structure of a production and configuration device for a live attenuated F genotype mumps vaccine proposed by the present invention;

[0020] Figure 4 This is a schematic diagram of the internal structure of a configuration housing of a device for producing a live attenuated F genotype mumps vaccine proposed by the present invention;

[0021] Figure 5 for Figure 4 A magnified view of part A;

[0022] Figure 6 This is a schematic diagram of the agitator structure of a production and configuration device for a live attenuated F genotype mumps vaccine proposed by the present invention.

[0023] In the accompanying drawings: 1. bracket, 2. premix unit, 3. configuration unit, 4. support platform, 5. interlayer, 6. inner layer, 7. annular liquid distributor, 8. drive shaft, 9. agitator, 10. feed hopper, 11. premix shell, 12. fixing frame, 13. agitator, 14. connecting port, 15. liquid outlet pipe, 16. liquid distribution port, 17. liquid inlet pipe, 18. slide, 19. connecting pipe, 20. baffle plate, 21. telescopic drive, 22. upper cover, 23. mounting plate, 24. short paddle, 25. long paddle, 26. fixing part. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0026] like Figure 1-5As shown, a production and configuration device for an F genotype mumps live attenuated vaccine comprises three parts: a bracket 1, a premix unit 2 and a configuration unit 3; the bracket 1 has corresponding supporting force, and a support platform 4 is configured on one side of the top, and the support platform 4 is used to support the premix unit 2; the premix unit 2 is configured on the support platform 4, and is connected to the configuration unit 3 through a connecting structure, and the premix can be injected into the configuration unit 3; the configuration unit 3 is configured on the bracket 1, and has a configuration shell, and the configuration shell includes an outer interlayer 5 and an inner layer 6 inside the interlayer 5, the connecting unit is connected to the inner layer 6, and the bottom of the inner layer 6 is configured with an annular liquid distributor 7 for distributing liquid from the bottom.

[0027] Among them, a fixed frame 12 of a predetermined height is fixed on the support platform 4, and the premix unit 2 includes a hopper 10 and a premix shell 11 connected to the hopper 10. The hopper 10 and the premix shell 11 are arranged on the fixed frame 12 of the support platform 4 from top to bottom. A stirring member 13 is rotatably arranged inside the premix unit, and a connection port 14 connected to the connecting structure is provided on the lower part of the side wall of the premix shell 11; a plurality of openings are provided at the top of the hopper 10, which can be respectively connected to a feeding device for auxiliary materials such as stabilizers and a water body for dissolving auxiliary materials, etc., so that appropriate auxiliary materials and water bodies are dissolved in water in sequence and premixed, so that a stirring member 13 is also rotatably arranged at the bottom of the premix shell 11, and the stirring member 13 is connected to the driving mechanism through a rotating shaft. The rotating shaft extends out of the bottom of the premix shell 11 and is connected to a belt driving mechanism. When the belt driving mechanism is started, the rotating shaft rotates, and the rotating shaft rotates and drives the stirring member 13 to rotate, and the stirring member 13 rotates to realize the premixing of the auxiliary materials.

[0028] In some preferred embodiments, the top of the inner layer 6 of the configuration unit 3 extends out of the interlayer 5, the interlayer 5 wraps the inner layer 6, the upper and lower side walls of the interlayer 5 are respectively connected to an inlet and an outlet, and refrigerated water can be introduced into the interlayer 5 to achieve stirring and mixing of the virus liquid and the premix under low temperature conditions, and the top of the inner layer 6 is provided with an upper cover 22, which is detachably fixed by bolts, and a temperature sensor and a liquid level sensor are provided on the inner side of the upper cover 22 to facilitate detection of the operating temperature and liquid level height inside the configuration shell.

[0029] Here, preferably, the connecting unit is connected between the lower side portion of the premix shell 11 and the top of the inner layer 6. Specifically, a connecting port 14 connected to the connecting structure is provided at the lower side wall of the premix shell 11. The connecting structure includes a slide 18 and a connecting pipe 19. The slide 18 is connected to the connecting port 14, and the connecting pipe 19 is connected to the inner layer 6. The slide 18 is provided with a baffle plate 20, and the baffle plate 20 is connected to a telescopic drive 21. The telescopic drive 21 is arranged on the outer wall of the premix shell 11. During the telescopic operation, the baffle plate 20 can be controlled to slide in and out of the top wall of the slide 18, which is used to open and close the slide 18, thereby controlling the release of the premix.

[0030] In some preferred embodiments, the configuration unit 3 includes a stirring mechanism configured on the inner layer 6, the stirring mechanism including a drive shaft 8 and an agitator 9 configured on the drive shaft 8. The drive shaft 8 is rotatably configured on the top of the inner layer 6 via a bearing. The top end of the drive shaft 8 extends out of the top end of the inner layer 6 and is connected to a rotary drive. The agitator 9 is provided in multiple numbers along the length of the drive shaft 8. The agitator 9 includes a mounting plate 23 configured on the drive shaft 8, and the mounting plate 23 is disc-shaped; short blades 24 and long blades 25 are spaced apart on the peripheral wall of the mounting plate 23, and the short blades 24 and long blades 25 are annularly spaced around the central axis of the mounting plate 23. After the rotary drive is activated (the speed is controlled within a predetermined range), the output end of the rotary drive rotates to drive the drive shaft 8, and the rotation of the drive shaft 8 drives the agitator 9 to rotate. When the agitator 9 is in operation, the short blades 24 and long blades 25 rotate to mix the virus liquid entering from the lower liquid distributor and the premix entering from above.

[0031] In this embodiment, it is preferred that the bottom of the inner layer 6 is connected to a liquid outlet pipe 15, the liquid outlet pipe 15 passes through the corresponding position of the interlayer 5 and extends to a predetermined length below the configuration shell, the liquid distributor is an annular hollow setting, the side wall is provided with a liquid distribution port 16, the liquid distribution port 16 is distributed in an annular spaced pattern, the bottom of the liquid distributor is connected to a liquid inlet pipe 17, the liquid inlet pipe 17 passes through the liquid outlet pipe 15, and the part located in the liquid outlet pipe 15 is fixed to the inner wall of the liquid outlet pipe 15 by a fixing member 26, one end of the liquid inlet pipe 17 passes through the side of the liquid outlet pipe 15 and is provided with a valve, and the end of the liquid outlet pipe 15 is provided with a valve.

[0032] Furthermore, preferably, the top end of the inner layer 6 extends out of the interlayer 5 and is bolted to a top cover 22. A liquid level sensor and a temperature sensor are disposed within the inner layer 6 to detect the liquid level and temperature within the inner layer 6. Upon detecting that the liquid level reaches a predetermined range, the liquid distributor stops injecting the virus liquid into the chamber of the inner layer 6. The inlet and outlet of the interlayer 5 can be used to inject a low-temperature medium into the interlayer 5, thereby maintaining a low-temperature operating environment within the chamber of the inner layer 6. The temperature sensor is used to detect the operating temperature of the inner layer 6.

[0033] Working principle: When in use, the entire device is installed in a suitable working position, and a low-temperature medium is injected into the interlayer 5 to maintain a low-temperature working environment in the inner layer 6; the premix is ​​mixed with auxiliary materials such as stabilizers, and after the premix is ​​mixed, the premix is ​​injected into the chamber of the inner layer 6 through the slide 18 and the connecting pipe 19, and the liquid distributor is started at the same time. The liquid inlet pipe 17 of the liquid distributor is connected to the liquid supply device of the virus liquid, and the virus liquid is injected into the chamber of the inner layer 6 through the liquid distribution port 16; the rotary drive is started, the agitator 9 is operated, and the stirring and mixing operation is performed in the chamber of the inner layer 6; during operation, the premix and virus liquid can be injected in stages to facilitate the mixing operation.

[0034] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents. In short, if those skilled in the art are inspired by the present invention and, without departing from the purpose of the present invention, design structures and embodiments similar to the technical solution without inventiveness, they shall fall within the scope of protection of the present invention.

Claims

1. A production and configuration device for a live attenuated F genotype mumps vaccine, characterized in that: include: The bracket has corresponding supporting force, and a support platform is configured on one side of the top, and the support platform is used to support the premix unit; The premix unit is arranged on the support platform and is connected to the configuration unit through a connecting structure, and the premix can be injected into the configuration unit; The configuration unit is configured on the bracket and has a configuration shell. The configuration shell includes an outer interlayer and an inner layer inside the interlayer. The connecting unit is connected to the inner layer. The bottom of the inner layer is configured with an annular liquid distributor for distributing liquid from the bottom.

2. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The configuration unit includes a stirring mechanism configured in the inner layer, the stirring mechanism includes a driving shaft and an agitator configured on the driving shaft, the driving shaft is rotatably configured at the top of the inner layer through a bearing, the top end of the driving shaft extends out of the top end of the inner layer and is connected to a rotation drive, and multiple agitators are arranged along the length direction of the driving shaft.

3. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The premix unit includes a feed hopper and a premix shell connected to the feed hopper. The feed hopper and the premix shell are arranged on a fixed frame of a support platform from top to bottom. A stirring member is rotatably arranged inside the premix unit. The stirring member is provided with a connection port connected to the connection structure at the lower part of the side wall of the premix shell.

4. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The bottom of the inner layer is connected to a liquid outlet pipe, which passes through the corresponding position of the interlayer and extends to a predetermined length below the configuration shell. The liquid distributor is an annular hollow setting with a liquid distribution port on the side wall. The bottom of the liquid distributor is connected to a liquid inlet pipe, which passes through the liquid outlet pipe and is located in the liquid outlet pipe and is fixed to the inner wall of the liquid outlet pipe by a fixing part. One end of the liquid inlet pipe passes through the side of the liquid outlet pipe and is provided with a valve, and a valve is provided at the end of the liquid outlet pipe.

5. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The upper portion and the lower portion of the interlayer side wall are respectively connected with an inlet and an outlet.

6. The device for producing and distributing a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The connecting structure includes a slide and a connecting pipe, the slide is connected to the connecting port, the connecting pipe is connected to the inner layer, the slide is equipped with a baffle plate, and the baffle plate is connected to a telescopic drive and can slide in and out of the slide for opening and closing the slide.

7. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The top end of the inner layer extends out of the interlayer and is provided with an upper cover via bolts. A liquid level sensor and a temperature sensor are provided inside the inner layer for detecting the liquid level and temperature in the inner layer.

8. The production and configuration device for a live attenuated F genotype mumps vaccine according to claim 1, characterized in that: The agitator includes a mounting plate, which is arranged on the drive shaft and is disc-shaped; short blades and long blades are arranged at intervals on the peripheral wall of the mounting plate, and the short blades and long blades are arranged in a ring-shaped manner around the central axis of the mounting plate.

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