Liquid spreading method, liquid spreading device and biochemical substance analysis system
The liquid spreading method using liquid and gas drive components in conjunction with nozzle components solves the problems of low efficiency and high cost of existing fluid loading devices, achieves rapid and uniform liquid film formation and efficient biochip liquid spreading, and is suitable for biochips of different sizes and shapes.
CN120591387APending Publication Date: 2025-09-05MGI TECH CO LTD
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Patent Information
- Application Number
- CN202410247001.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-04
- Publication Date
- 2025-09-05
AI Technical Summary
Technical Problem
Existing fluid loading devices have problems such as long fluid loading time, low efficiency, large liquid film thickness, large fluid loss and high cost.
Method used
A liquid drive component and a gas drive component are combined with a nozzle component to form a spray through mixing and load it into the biological functional layer of the biochip. The nozzle component can move to form a uniform liquid film, and the nozzle drive mechanism is used to control the thickness and coverage area of the liquid film.
Benefits of technology
It achieves rapid and uniform liquid film formation, reduces fluid consumption, lowers costs, and improves liquid spreading efficiency and sequencing throughput, and is adaptable to biochips of different sizes and shapes.
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Smart Images
Figure CN120591387A_ABST
Abstract
The invention discloses a liquid spreading method, a liquid spreading device and a biochemical substance analysis system, and the liquid spreading method comprises the following steps: conveying liquid in a liquid storage assembly to a nozzle assembly through a liquid driving assembly, and conveying compressed gas to the nozzle assembly through a gas driving assembly; the liquid and the compressed gas are mixed through the nozzle assembly to form mist spray, the mist spray is loaded to a biological function layer of the biological chip to form a liquid film, the biological function layer is used for fixing the biological sample, and the biological chip is an open type slide glass. According to the liquid spreading method and device based on the two-phase flow, the liquid spreading efficiency is high, the liquid film thickness can be effectively controlled, the liquid consumption is reduced, the cost is reduced, and the sequencing flux is improved.
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