A liquid crystal biomimetic water-locking and oxygen-permeable nursing composition, its preparation method and application

Abstract

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a liquid crystal biomimetic water-locking and oxygen-permeable care composition, its preparation method, and its application. Background Technology

[0002] As research into the physiological structure and mechanisms of the skin deepens, our understanding of the skin barrier is becoming increasingly clear, and we are increasingly aware that a healthy skin barrier is the primary factor in maintaining healthy skin. The most common skin manifestation caused by a damaged skin barrier is sensitive skin. At the same time, most skin diseases also involve a damaged skin barrier, such as acne, seborrheic dermatitis, melasma, rosacea, and hormone-dependent dermatitis.

[0003] Human skin is a metabolic system, and the skin barrier is also a multi-dimensional and multi-faceted system that interacts and influences each other. From the outermost sebum film to the most important brick-and-mortar structure, to the water regulation mechanisms such as aquaporins and natural moisturizing factors, to the inflammation and immune regulation mechanisms, and finally to the activation and remodeling of the dermis, each layer has its own appropriate regulatory mechanism. If any link has a problem, it will induce problems in other links, thus forming a vicious cycle.

[0004] Vernix caseosa is a natural biological protective film covering the surface of the fetus's skin. It not only effectively isolates the invasion of pollutants from the alkaline environment of amniotic fluid, but also protects and promotes fetal skin development. Recent research progress both domestically and internationally on the composition, efficacy, and simulated applications of vernix caseosa has revealed its moisturizing, antibacterial, and epidermal barrier-promoting effects, effectively mitigating blue light damage to human skin. However, since natural vernix caseosa cannot be directly used to prepare skincare products, most existing vernix caseosa-based skincare products are made using biomimetic vernix caseosa.

[0005] For example, Chinese patent CN115501138A discloses a biomimetic vernix caseosa composition, its preparation method, and its application. The biomimetic vernix caseosa composition consists of three phases: A, B, and C. Phase A comprises hydrogenated lecithin, glycerol, biosaccharide gum-2, sodium hyaluronate, and deionized water; phase B comprises ceramide-3, cholesterol, beeswax, stearic acid, caprylic / capric triglycerides, squalane, sea buckthorn fruit oil, and tocopherol; and phase C comprises superoxide dismutase, tripeptide-1 copper, kava extract, capsicum fruit extract, agave leaf extract, and bifida ferment lysate. This biomimetic vernix caseosa composition can better repair the skin barrier and increase the skin's resistance.

[0006] For example, Chinese patent CN117122533B discloses a biomimetic vernix caseosa composition, its preparation method, and its application. This biomimetic vernix caseosa composition, by mass percentage, comprises the following components: 0.1-5% pentacyclic triterpenoids, 9.8-50% plant oils, 10-30% purified plant oil components, 30-70% plant oil derivatives, and 0.1-5% plant-derived ceramides. This biomimetic vernix caseosa composition significantly enhances the protective and repairing effects on the skin, strengthening its resistance. The biomimetic vernix caseosa film prepared from this composition has a good liquid crystal structure, similar to that of natural vernix caseosa, and shows promising application prospects.

[0007] However, the existing biomimetic skincare compositions cannot adequately meet the requirements in terms of long-term moisturizing and water-locking effects and stability. Therefore, it is necessary to develop a liquid crystal biomimetic water-locking and oxygen-permeable care composition with good long-term moisturizing and water-locking effects, as well as repair of damaged skin barriers and high stability, and its preparation method. Summary of the Invention

[0008] In view of the shortcomings of the existing technology, the present invention aims to provide a liquid crystal biomimetic water-locking and oxygen-permeable care composition with good long-term moisturizing and water-locking effect and repair of damaged skin barrier, as well as its preparation method and application.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A liquid crystal biomimetic water-locking and oxygen-permeable care composition, comprising the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water.

[0011] Preferably, the liquid crystal biomimetic water-locking and oxygen-permeable care composition comprises, by weight percentage, the following components: 22-38% glycerol, 6-8% hydrogenated lecithin, 6-8% phytosterols, 0.2-0.4% sodium stearoyl glutamate, 0.02-0.04% sodium methylstearoyl taurate, 0.3-0.8% ceramide NP, 3-8% caprylic / capric triglycerides, 3-8% squalane, 0.3-0.8% tocopheryl acetate, 0.05-0.25% sodium DNA, 0.005-0.08% fibronectin, 0.005-0.08% soluble collagen, and the balance being water.

[0012] More preferably, the liquid crystal biomimetic water-locking and oxygen-permeable care composition comprises, by weight percentage, the following components: 25-35% glycerol, 7-8% hydrogenated lecithin, 7-8% phytosterols, 0.25-0.35% sodium stearoyl glutamate, 0.025-0.035% sodium methylstearoyl taurate, 0.5-0.7% ceramide NP, 4-6% caprylic / capric triglyceride, 4-6% squalane, 0.4-0.7% tocopheryl acetate, 0.1-0.2% sodium DNA, 0.01-0.05% fibronectin, 0.01-0.05% soluble collagen, and the balance being water.

[0013] The preferred phytosterols are β-sitosterol.

[0014] Of the above components:

[0015] Glycerin: It can be used as a solvent to help dissolve other ingredients; in addition, as a moisturizing ingredient, it can lock in skin moisture and keep the skin hydrated; it can also be used as a carrier matrix for formulating liquid crystal emulsions.

[0016] Hydrogenated lecithin retains the biocompatibility of natural lecithin and serves as a carrier for encapsulating liposome raw materials. By encapsulating the raw materials, it enhances the targeting of the delivery and promotes the penetration of active ingredients. It also has emulsifying and moisturizing functions. When combined with glycerin and phytosterols, it forms a liquid crystal emulsion with strong affinity for skin and mucous membranes. It can be absorbed by human skin and hair, while moisturizing the skin or hair and promoting the penetration of other nutrients.

[0017] Phytosterols: Possessing hydrophilic and lipophilic groups, they combine with glycerin and lecithin to form liquid crystal emulsifiers, similar in structure to human skin, resulting in a lightweight and easily absorbed feel. They form a barrier on the skin surface, reducing moisture loss and promoting wound healing. They alleviate skin inflammation and allergic reactions, making them suitable for sensitive skin or post-sunburn care. They inhibit excessive sebum secretion, improving oily skin conditions. With high skin permeability, they can promote skin metabolism, inhibit skin inflammation, and also repair sunburn erythema and delay skin aging.

[0018] Sodium stearoyl glutamate: an oil-in-water (O / W) emulsifier that maintains good surface activity and stability in hard water environments, unaffected by metal ions such as calcium and magnesium in water, and can perform its cleaning and emulsifying functions normally; it is highly biodegradable, easily decomposes in the environment, and will not cause environmental pollution, in line with the concept of green environmental protection; it is gentle and non-irritating, and suitable for people with dry and sensitive skin.

[0019] Sodium methylstearoyl taurate: an oil-in-water (O / W) emulsifier that maintains good surface activity and stability even in hard water environments. It is safe, non-irritating to the skin, highly biodegradable, and easily decomposes in the environment without causing pollution, aligning with green environmental protection principles. It is gentle and non-irritating, suitable for dry and sensitive skin.

[0020] Ceramide NP: Fills the intercellular spaces of the stratum corneum, forming a "brick wall structure" together with cholesterol and free fatty acids to prevent moisture loss, replenish missing lipids, accelerate barrier repair, and resist external stimuli; reduces skin inflammation and relieves sensitive symptoms such as redness and itching, making it especially suitable for sensitive skin or post-cosmetic treatment repair; enhances skin elasticity, reduces fine line formation, and delays skin aging caused by decreased barrier function; naturally present in the skin and non-irritating; applied to liposome encapsulation technology, it can improve permeability.

[0021] Caprylic / capric triglycerides: These are compatible with human skin, have a non-greasy texture, and provide lubrication and softening effects.

[0022] Squalane: Naturally derived, with a stable molecular structure and high compatibility with human skin lipids, it can quickly penetrate the skin to form a thin, light protective film that is lightweight and non-sticky. It improves skin absorption, leaving skin smooth and pore-free; it can inhibit free radical damage to the skin and help delay skin aging; it replenishes skin lipids, enhances the stratum corneum barrier function, and improves problems such as sensitivity and redness caused by barrier damage; it reduces skin inflammation, relieves irritation, and neutralizes free radicals, reducing damage to the skin from ultraviolet rays and pollution.

[0023] Tocopheryl acetate: It can neutralize free radicals, reduce skin damage caused by ultraviolet rays and pollution, and delay collagen loss; after penetrating the skin, it releases tocopherol, enhances the water-locking ability of the stratum corneum, and improves dryness and roughness; it also relieves skin inflammation and redness.

[0024] Sodium DNA: It can reduce the excessive reaction of sensitive skin to external stimuli, alleviate sensitivity symptoms, regulate skin microcirculation, reduce redness, inhibit acne inflammation, promote acne repair, and promote the regeneration of various growth factors, which helps rebuild the skin barrier function; it can secrete a small amount of collagen and non-collagen substances, continuously stimulate fibroblasts to secrete extracellular matrix, increase the regeneration of collagen, elastic fibers, and reticular fibers, reduce wrinkles, and improve skin firmness; it can repair DNA damage by recycling and integrating bases and nucleosides, accelerate the repair of damaged cells, promote wound healing, and accelerate cell metabolism.

[0025] Fibronectin: It has anti-inflammatory properties, can regulate the activity of inflammatory cells, inhibit the release of inflammatory factors, participate in wound healing and tissue repair processes, mobilize the mononuclear phagocyte system to clear harmful substances in damaged tissues, and can also stimulate cell migration, adhesion and proliferation, promoting the regeneration of damaged tissues.

[0026] Soluble collagen: The hydrophilic groups in its molecules can form hydrogen bonds with water molecules, adsorbing and locking in moisture in large quantities, keeping the stratum corneum of the skin sufficiently hydrated; it forms a breathable protective film on the skin surface, reducing skin moisture loss and helping to repair damaged skin barriers; it directly replenishes the collagen needed by the skin, filling the gaps between skin cells, stimulating the activity of skin fibroblasts, promoting the synthesis of more collagen and elastin fibers, and restoring the skin to a youthful state; it inhibits tyrosinase activity, reduces melanin formation, promotes skin cell metabolism, and accelerates the shedding of melanin from the skin surface; it has anti-inflammatory properties, which can reduce skin inflammation, relieve discomfort such as redness, swelling, and itching, promote skin cell proliferation and differentiation, and accelerate wound healing.

[0027] In a preferred embodiment, the mass ratio of glycerol, hydrogenated lecithin, and phytosterols is 2-4:0.5-1:0.5-1;

[0028] More preferably, the mass ratio of glycerol, hydrogenated lecithin, and phytosterols is 2.5-3.5:0.6-0.8:0.6-0.8;

[0029] More preferably, the mass ratio of glycerol, hydrogenated lecithin, and phytosterols is 3.2:0.8:0.8.

[0030] During the implementation of this invention, it was discovered that controlling the mass ratio of glycerin, hydrogenated lecithin, and phytosterols allows the three to be better combined to form a liquid crystal emulsion, which is similar to the structure of human skin, has a light feel, and is easily absorbed; it forms a barrier on the skin surface, reduces moisture loss, and promotes wound healing.

[0031] As another preferred embodiment, the mass ratio of sodium DNA, fibronectin, and soluble collagen is 10-20:1-5:1-5;

[0032] More preferably, the mass ratio of sodium DNA, fibronectin, and soluble collagen is 12-18:2-4:2-4;

[0033] More preferably, the mass ratio of sodium DNA, fibronectin, and soluble collagen is 15:3:3.

[0034] During the implementation of this invention, it was discovered that by controlling the mass ratio of sodium DNA, fibronectin, and soluble collagen, a breathable protective film can be formed on the skin surface more effectively, reducing skin moisture loss and helping to repair the damaged skin barrier, thereby achieving the effect of water-locking and oxygen-permeable care.

[0035] The mass ratio of sodium stearoyl glutamate to sodium methylstearoyl taurate is 5-20:1; preferably 8-15:1; and even more preferably 10:1.

[0036] During the implementation of this invention, it was unexpectedly discovered that adding sodium stearoyl glutamate and sodium methylstearoyl taurate to the components, and controlling their mass ratio to be 5-20:1, can significantly improve the stability of the product. When combined with glycerin, hydrogenated lecithin and phytosterols, as well as sodium DNA, fibronectin and soluble collagen, the composition can significantly improve its moisturizing and water-locking effects, and is refreshing, lightweight and breathable.

[0037] As a preferred embodiment, the liquid crystal biomimetic water-locking and oxygen-permeable care composition comprises, by weight percentage, the following components: 32% glycerol, 8% hydrogenated lecithin, 8% phytosterols, 0.3% sodium stearoyl glutamate, 0.03% sodium methylstearoyl taurate, 0.6% ceramide NP, 5% caprylic / capric triglyceride, 5% squalane, 0.6% tocopheryl acetate, 0.15% sodium DNA, 0.03% fibronectin, 0.03% soluble collagen, and the balance being water.

[0038] The present invention also provides a method for preparing the above-mentioned liquid crystal biomimetic water-locking and oxygen-permeable care composition, comprising the following steps:

[0039] (1) Mix glycerol, hydrogenated lecithin, phytosterols, sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 10-15 minutes to obtain liquid crystal emulsifier base material A;

[0040] (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B;

[0041] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C;

[0042] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture;

[0043] (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0044] The present invention also provides the application of the above-mentioned liquid crystal biomimetic water-locking and oxygen-permeable care composition in the preparation of biomimetic water-locking and oxygen-permeable care cosmetics.

[0045] The aforementioned biomimetic water-locking and oxygen-permeable cosmetic products include skin care products, hair care products, or washing products.

[0046] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0047] (1) The present invention adds phytosterols to the components and unexpectedly found that controlling the mass ratio of glycerol, hydrogenated lecithin and phytosterols can better combine the three to form a liquid crystal emulsion, which is similar to the structure of human skin, has a light feel and is easily absorbed; it forms a barrier on the skin surface, reduces moisture loss, and promotes wound healing.

[0048] (2) In the process of implementation, it was found that by controlling the mass ratio of sodium DNA, fibronectin and soluble collagen, a breathable protective film can be formed on the skin surface, reducing skin moisture loss and helping to repair the damaged skin barrier, thereby achieving the effect of water-locking and oxygen-permeable care.

[0049] (3) In this invention, sodium stearoyl glutamate and sodium methylstearoyl taurate are added to the components and the mass ratio of the two is controlled to be 5-20:1, which can significantly improve the stability of the product. When combined with glycerin, hydrogenated lecithin and phytosterols, as well as sodium DNA, fibronectin and soluble collagen, the water-replenishing and water-locking effect of the composition can be significantly improved, and it is refreshing, not heavy and breathable. Attached Figure Description

[0050] Figure 1 The tissue structure diagram of the liquid crystal biomimetic water-locking and oxygen-permeable nursing composition prepared in Example 4 (scale bar is 20 μm). Detailed Implementation

[0051] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0052] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0053] The following are the manufacturers and models of the raw materials used, as shown in Table 1 below.

[0054] Table 1

[0055]

[0056]

[0057] Example 1: A liquid crystal biomimetic water-locking and oxygen-permeable nursing composition and its preparation method

[0058] It consists of the following components by weight percentage: 20% glycerol, 5% hydrogenated lecithin, 5% β-sitosterol, 0.1% sodium stearoyl glutamate, 0.02% sodium methylstearoyl taurate, 0.2% ceramide NP, 2.5% caprylic / capric triglyceride, 1.5% squalane, 0.2% tocopheryl acetate, 0.02% sodium DNA, 0.002% fibronectin, 0.002% soluble collagen, and the balance being water.

[0059] Preparation method:

[0060] (1) Mix glycerol, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 15 minutes to obtain liquid crystal emulsifier base material A;

[0061] (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B;

[0062] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C;

[0063] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture;

[0064] (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0065] Example 2: A liquid crystal biomimetic water-locking and oxygen-permeable nursing composition and its preparation method

[0066] The product is composed of the following components by weight percentage: 40% glycerol, 10% hydrogenated lecithin, 10% β-sitosterol, 0.5% sodium stearoyl glutamate, 0.04% sodium methylstearoyl taurate, 1% ceramide NP, 10% caprylic / capric triglyceride, 10% squalane, 1% tocopheryl acetate, 0.3% sodium DNA, 0.1% fibronectin, 0.1% soluble collagen, and the balance being water.

[0067] Preparation method:

[0068] (1) Mix glycerol, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 15 minutes to obtain liquid crystal emulsifier base material A;

[0069] (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B;

[0070] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C;

[0071] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture;

[0072] (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0073] Example 3: A liquid crystal biomimetic water-locking and oxygen-permeable nursing composition and its preparation method

[0074] The product is composed of the following components by weight percentage: 25% glycerol, 6% hydrogenated lecithin, 6% β-sitosterol, 0.4% sodium stearoyl glutamate, 0.05% sodium methylstearoyl taurate, 0.6% ceramide NP, 4% caprylic / capric triglyceride, 8% squalane, 0.3% tocopheryl acetate, 0.25% sodium DNA, 0.03% fibronectin, 0.04% soluble collagen, and the balance being water.

[0075] Preparation method:

[0076] (1) Mix glycerol, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 15 minutes to obtain liquid crystal emulsifier base material A;

[0077] (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B;

[0078] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C;

[0079] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture;

[0080] (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0081] Example 4: A liquid crystal biomimetic water-locking and oxygen-permeable nursing composition and its preparation method

[0082] The product is composed of the following components by weight percentage: 32% glycerol, 8% hydrogenated lecithin, 8% β-sitosterol, 0.3% sodium stearoyl glutamate, 0.03% sodium methylstearoyl taurate, 0.6% ceramide NP, 5% caprylic / capric triglyceride, 5% squalane, 0.6% tocopheryl acetate, 0.15% sodium DNA, 0.03% fibronectin, 0.03% soluble collagen, and the balance being water.

[0083] Preparation method:

[0084] (1) Mix glycerol, hydrogenated lecithin, β-sitosterol, sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 15 minutes to obtain liquid crystal emulsifier base material A;

[0085] (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B;

[0086] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C;

[0087] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture;

[0088] (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0089] Comparative Example 1:

[0090] The difference from Example 4 is that sodium stearoyl glutamate is not added; instead, it is replaced with sodium methylstearoyl taurate, i.e., 0.33% sodium methylstearoyl taurate. All other components and their contents remain the same as in Example 4. Sodium stearoyl glutamate is not added during the preparation process.

[0091] Comparative Example 2:

[0092] The difference from Example 4 is that sodium stearoyl glutamate is replaced with octadecyl alcohol, and the octadecyl alcohol content is 0.3% and sodium methylstearoyl taurate content is 0.03%, while the other components and contents are the same as in Example 4. Octadecyl alcohol is added during the preparation process.

[0093] Comparative Example 3:

[0094] The difference from Example 4 is that the mass ratio of sodium stearoyl glutamate and sodium methylstearoyl taurate is 1:10, i.e., sodium stearoyl glutamate 0.03% and sodium methylstearoyl taurate 0.3%. All other components and their contents are the same as in Example 4. The preparation process is the same as in Example 4.

[0095] Comparative Example 4:

[0096] The difference from Example 4 lies in the preparation method, specifically:

[0097] (1) Mix glycerol, hydrogenated lecithin and β-sitosterol and heat to 85-90℃, stir for 15 minutes to obtain liquid crystal emulsifier base material A;

[0098] (2) Mix sodium stearoyl glutamate and sodium methylstearoyl taurate and heat to 85-90℃, stir for 10 minutes to obtain mixture B;

[0099] (3) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution C;

[0100] (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution D;

[0101] (4) Keep the liquid crystal emulsifier base material A at 85-90℃, and slowly add the mixture B and solution C under stirring conditions. Stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain the mixture.

[0102] (5) Slowly add solution D to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

[0103] Comparative Example 5:

[0104] The difference from Example 4 is that the mass ratio of glycerol, hydrogenated lecithin, and β-sitosterol is 14:1:1, i.e., glycerol 42%, hydrogenated lecithin 3%, and β-sitosterol 3%. All other components and their contents are the same as in Example 4. The preparation process is the same as in Example 4.

[0105] Effect Experiment:

[0106] 1. Stability testing

[0107] The products prepared in Examples 1-4 and Comparative Examples 1-4 were subjected to stability tests at constant temperatures of 50℃, 37℃, 25℃, 4℃, and -10℃, and at cyclic temperatures of -10℃ to 45℃. The stability of the products was recorded after 1 day, 3 weeks, 1 month, and 3 months. A qualified product showed no precipitation, off-odor, or discoloration, and its viscosity and pH remained unchanged. √ indicates normal; × indicates a change in one or more of the following: odor, color, uniformity, viscosity, and pH. The test results are shown in Table 2.

[0108] Table 2

[0109]

[0110]

[0111] As shown in Table 2, when the compositions prepared in Examples 1-4 of this invention were tested for stability at 50°C, 37°C, 25°C, 4°C, -10°C and a cycling temperature of -10-45°C, no precipitation, off-odor, or discoloration occurred in the samples after 3 months, and their viscosity and pH did not change significantly. This indicates that the compositions prepared in Examples 1-4 have good stability.

[0112] In Comparative Examples 1-3, changing the type or mass ratio of components—that is, adding only sodium stearoyl glutamate as the surfactant, replacing sodium stearoyl glutamate with octadecyl alcohol (another type of surfactant), or changing the mass ratio of sodium stearoyl glutamate to sodium methylstearoyl taurate—all affected the formation of the network structure during the preparation of the liquid crystal composition, thereby affecting the stability of the composition. As a result, the product performance changed after the third or sixth month of cycling at 50℃, 37℃, -10℃, and -10-45℃, indicating that the stability test was unsatisfactory. This demonstrates that the compositions prepared in Comparative Examples 1-3 had poor stability.

[0113] In Comparative Example 4, the preparation method was changed by mixing sodium stearoyl glutamate and sodium methylstearoyl taurate separately before mixing them with other components. This prevented the formation of a liquid crystal emulsion during the preparation process, thus affecting the stability of the composition. As a result, the product performance changed after the third month, the sixth month, or even the third week of cycling at 50°C, 37°C, -4°C, -10°C, and -10-45°C, indicating that the stability test was unsatisfactory. This shows that the composition prepared in Comparative Example 4 had the worst stability.

[0114] 2. Test on water-locking, moisturizing, and barrier repair effects

[0115] Test method: 70 volunteers were recruited, females aged 35-45 years, who met the inclusion and exclusion criteria of the "Cosmetic Safety Technical Specifications".

[0116] Volunteers were randomly divided into 10 groups and used the compositions prepared in Examples 1-4, Comparative Examples 1-2, and Comparative Example 5, respectively.

[0117] The skin stratum corneum moisture content was measured using a Corneometer CM825 (Courage Khazaka, Germany), and the skin transepidermal water loss rate was measured using a Tewameter™ Hex.

[0118] Apply 10 mg of the composition evenly to the cheek area of ​​the subject, once in the morning and once in the evening, for 4 consecutive weeks. Before the test, all subjects cleaned their faces and rested in a constant temperature and humidity room for 30 minutes.

[0119] The formula for calculating the relative increase in skin stratum corneum moisture content is: Relative increase in skin stratum corneum moisture (%) = (Measurement value after application - Measurement value before application) / Measurement value before application × 100%. The greater the relative increase in skin stratum corneum moisture (%), the better the moisturizing effect.

[0120] The formula for calculating the improvement rate (%) of transepidermal water loss is: Improvement rate (%) of transepidermal water loss = (1 - measured value after application / measured value before application) × 100%. A higher improvement rate (%) indicates a better moisturizing effect. Transepidermal water loss volume (TEWL) is an important parameter for assessing the function of the skin's moisture barrier and can be used to evaluate the strength of the skin barrier function. A decrease in TEWL indicates a stronger skin barrier repair effect. Results are rounded to one decimal place. The test results are shown in Table 3 below.

[0121] And rate the user experience after use, with the following evaluation criteria:

[0122] Breathability: Rating 0 out of 5, where 0 indicates extremely poor breathability and 5 indicates good breathability. The final average value is taken and rounded to one decimal place.

[0123] Oiliness: Rating 0-5 points, 0 points is very oily; 5 points is refreshing and not oily. The final average is taken and one decimal place is retained.

[0124] Skin firmness: Level 1: Significant improvement in skin firmness and wrinkles; Level 2: Moderate improvement in skin firmness and wrinkles; Level 3: No improvement in skin firmness and wrinkles.

[0125] The test results are shown in Table 4 below.

[0126] Table 3

[0127] Relative increase in moisture content of the stratum corneum (%) Improvement rate of transepidermal water loss in the skin (%) Example 1 80.2 43.8 Example 2 82.5 42.5 Example 3 80.4 43.4 Example 4 83.9 46.7 Comparative Example 1 72.4 30.5 Comparative Example 2 75.2 35.1 Comparative Example 5 78.6 39.4

[0128] Table 4

[0129]

[0130]

[0131] According to the test results in Table 3 and the evaluation results in Table 4, after using the compositions prepared in Examples 1-4 of this invention for 4 weeks, the water content of the stratum corneum of the skin increased significantly, indicating that the compositions prepared in this invention have better moisturizing and water-locking effects; the decrease in skin moisture loss indicates that the compositions prepared in this invention have a good effect on repairing damaged skin barriers, and have good breathability, are refreshing and non-greasy, and have excellent skin-tightening effects.

[0132] In Comparative Examples 1-2, changing the type of surfactant, i.e., adding only sodium stearoyl glutamate or replacing sodium stearoyl glutamate with octadecyl alcohol (other types of surfactants), affects the formation of the network structure of the liquid crystal composition, thereby affecting the fluidity of the composition. This weakens the moisturizing and water-locking effect and reduces the improvement rate of transepidermal water loss, indicating that the barrier repair effect of the composition is weakened. Consequently, it affects the breathability, freshness and skin-tightening effect of the composition to a certain extent, resulting in a decline in user experience.

[0133] In Comparative Example 5, changing the mass ratio of glycerol, hydrogenated lecithin, and β-sitosterol also affected the compounding effect of the liquid crystal emulsifier, thereby affecting the moisturizing and water-locking effect and barrier repair effect of the composition, resulting in a reduced user experience.

[0134] In summary, the composition prepared by this invention can form a stable and long-lasting moisture-locking barrier on the skin surface, thereby improving the moisturizing effect and the repair effect of the damaged barrier. It also has good breathability and skin-tightening effect, and is refreshing and non-greasy, providing a good user experience.

[0135] The embodiments presented herein are merely illustrative of selected implementations based on combinations of all possible embodiments. The appended claims are not intended to limit the selection of examples illustrating the features of the invention. Some numerical ranges used in the claims also include sub-ranges within them, and variations within these ranges should be interpreted as being covered by the appended claims where possible.

Claims

1. A liquid crystal biomimetic water-locking and oxygen-permeable care composition, characterized in that: The product is composed of the following components by weight percentage: 20-40% glycerol, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The mass ratio of sodium stearoyl glutamate to sodium methylstearoyl taurate is 5-20:1; The mass ratio of glycerol, hydrogenated lecithin, and phytosterols is 2-4:0.5-1:0.5-1; The mass ratio of sodium DNA, fibronectin, and soluble collagen is 10-20:1-5:1-5; The preparation method of the aforementioned liquid crystal biomimetic water-locking and oxygen-permeable care composition includes the following steps: (1) Mix glycerol, hydrogenated lecithin, phytosterols and sodium stearoyl glutamate and heat to 85-90℃, stir for 10-15 minutes to obtain liquid crystal emulsifier base material A; (2) Mix ceramide NP, caprylic / capric triglyceride, squalane and tocopheryl acetate and stir until homogeneous to obtain solution B; (3) Add sodium DNA, fibronectin and soluble collagen to water and disperse evenly to obtain solution C; (4) Keep the liquid crystal emulsifier base material A at 85-90℃, slowly add solution B under stirring, stir and disperse evenly, and then keep the temperature constant for 20 minutes to obtain a mixture; (5) Slowly add solution C to the mixture, then perform high-speed emulsification and homogenization for 10 minutes, then continue to stir at a constant temperature for 20 minutes, and then cool down to 45°C and stir evenly to obtain the liquid crystal biomimetic water-locking and oxygen-permeable care composition.

2. The liquid crystal biomimetic water-locking and oxygen-permeable nursing composition according to claim 1, characterized in that: It consists of the following components by weight percentage Composition: Glycerin 22-38%, Hydrogenated lecithin 6-8%, Phytosterols 6-8%, Sodium stearoyl glutamate 0.2-0.4%, Sodium methylstearoyl taurate 0.01-0.04%, Ceramide NP 0.3-0.8%, Caprylic / Capric triglycerides 3-8%, Squalane 3-8%, Tocopheryl acetate 0.3-0.8%, Sodium DNA 0.05-0.25%, Fibronectin 0.005-0.08%, Soluble collagen 0.005-0.08%, and water balance.

3. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 2, characterized in that: It consists of the following components by weight percentage Composition: 25-35% glycerol, 7-8% hydrogenated lecithin, 7-8% phytosterols, 0.25-0.35% sodium stearoyl glutamate, 0.025-0.035% sodium methylstearoyl taurate, 0.5-0.7% ceramide NP, 4-6% caprylic / capric triglycerides, 4-6% squalane, 0.4-0.7% tocopheryl acetate, 0.1-0.2% sodium DNA, 0.01-0.05% fibronectin, 0.01-0.05% soluble collagen, and water as the balance.

4. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: The mass ratio of sodium stearoyl glutamate to sodium methylstearoyl taurate is 10:

1.

5. The liquid crystal biomimetic water-locking and oxygen-permeable care composition according to claim 1, characterized in that: It consists of the following components by weight percentage Composition: 32% glycerol, 8% hydrogenated lecithin, 8% phytosterols, 0.3% sodium stearoyl glutamate, 0.03% sodium methylstearoyl taurate, 0.6% ceramide NP, 5% caprylic / capric triglyceride, 5% squalane, 0.6% tocopheryl acetate, 0.15% sodium DNA, 0.03% fibronectin, 0.03% soluble collagen, and the balance being water.

6. The use of the liquid crystal biomimetic water-locking and oxygen-permeable care composition according to any one of claims 1-5 in the preparation of biomimetic water-locking and oxygen-permeable cosmetics.

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