Liquid face cream for repairing skin through lipid barrier and cosmetic prepared from liquid face cream

Abstract

The invention discloses a liquid face cream for repairing skin through a lipid barrier and a cosmetic prepared from the liquid face cream, the liquid face cream is prepared from a humectant, lecithin, a preservative, an emollient, ceramide, shea butter, squalane, hydrogenated phosphatidylcholine, a radix ophiopogonis root extract and the balance of deionized water, and the invention relates to the technical field of cosmetics. According to the liquid face cream for repairing the skin through the lipid barrier and the cosmetics prepared from the liquid face cream, the stability and the transdermal absorption rate of ceramide are remarkably improved through a lipid wrapping technology and a bionic proportion, meanwhile, the excellent barrier repairing effect of improving the water content of a cuticle and reducing transdermal water loss is achieved, and the liquid face cream is simple in formula, safe, mild and capable of being matched with multiple dosage forms.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, in particular to a liquid facial cream for repairing skin through a lipid barrier and a cosmetic prepared therefrom. Background Art

[0002] Ceramide is a type of sphingolipid composed of long-chain sphingosine bases and fatty acids. Ceramide is the main lipid component of the stratum corneum, accounting for approximately 40-50%. It has a strong ability to associate with water molecules and plays an important role in retaining moisture in the stratum corneum and maintaining the skin's barrier function. It can improve dryness, scaling, and roughness of the skin. It can also enhance skin elasticity and delay skin aging.

[0003] The existing technology has the following problems with ceramides: poor stability, easy crystallization and precipitation in finished products, high lipophilicity leading to low water solubility and poor formulation compatibility; low skin absorption efficiency and insufficient bioavailability. Existing technologies often improve the above problems by adding large amounts of emulsifiers or chemical stabilizers, but this can easily cause skin irritation or complicate the formulation. Summary of the Invention

[0004] In response to the shortcomings of the existing technology, the present invention provides a liquid facial cream that repairs the skin through a lipid barrier and the cosmetics prepared therefrom, which solves the problems of poor stability of ceramide, easy crystallization and precipitation of the finished product, low water solubility and poor formula compatibility due to high lipophilicity, low skin absorption efficiency and insufficient bioavailability. The existing technology mostly adds a large amount of emulsifiers or chemical stabilizers, but it can easily cause skin irritation or complicate the formula.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solution: a liquid cream for repairing skin through a lipid barrier, comprising the following components by mass percentage: 1-30% of a moisturizing agent, selected from at least two of glycerin, 1,3-propylene glycol, methylpropanediol, butylene glycol, and dipropylene glycol; 0.1-2% lecithin, selected from a mixture of soybean lecithin and lysolecithin, with a ratio of (2:1) to (4:1); Preservative 0.5-3%, composed of hexylene glycol and phenoxyethanol in a ratio of (1:1)-(3:1); 5-15% emollient, at least two selected from caprylic / capric triglyceride, glyceryl tri(ethylhexanoate), and octyldodecanol; Ceramide 0.1-1%, comprising ceramide EOP, NS, and AP, and the molar ratio of the three is (1.5:1:1)-(2.5:1:1); Shea butter 1-10%, squalane 0.5-8%, hydrogenated phosphatidylcholine 1-5%; Ophiopogon root extract 0.05-0.5%; The balance is deionized water; The composition is prepared by the following steps: Heat the moisturizer, lecithin, and preservative at 80-90°C and disperse them uniformly to form an aqueous phase; (2) Dissolve ceramide and emollient at 90-95°C, add hydrogenated phosphatidylcholine, shea butter, squalane and ophiopogon root extract, and mix to form an oil phase; (3) Mix the water phase and the oil phase at 75-85°C and homogenize at 3000-6000 rpm for 3-10 minutes; The mixture was transferred to a high-pressure homogenizer and homogenized 1-3 times under a pressure of 1000-2000 Bar to form nanoliposomes with a particle size of ≤200 nm; (5) Cool to 30-45℃ and then repackage.

[0006] Preferably, the moisturizing agent is a mixture of glycerol and 1,3-propylene glycol in a mass ratio of (3:1) to (5:1).

[0007] Preferably, the lecithin is a mixture of soybean lecithin and lysolecithin in a ratio of 3:1, and the total content is 0.5-1.5%.

[0008] Preferably, the molar ratio of the ceramides EOP, NS and AP is 2:1:1, and the total content is 0.3-0.8%.

[0009] Preferably, the emollient is a mixture of caprylic / capric triglyceride and triethylhexanoin in a ratio of (1:1) to (2:1).

[0010] Preferably, the pressure of the high-pressure homogenization step (4) is 1400-1600 Bar, and the homogenization times are 2 times.

[0011] The present invention also discloses a cosmetic for repairing skin through a lipid barrier, comprising the composition according to any one of claims 1 to 6, wherein the cosmetic consists of the composition.

[0012] Preferably, the cosmetic is an essence, lotion, cream or mask, and has a pH value of 5.0-6.5.

[0013] The present invention also discloses a method for preparing a cosmetic for repairing skin through a lipid barrier, comprising the following steps: (1) Preparation of aqueous phase: Stir and disperse the moisturizer, lecithin, and preservative at 85±5°C for 20-30 minutes to form a uniform transparent liquid; (2) Preparation of oil phase: Heat ceramide and emollient at 95±2℃ until completely dissolved, add hydrogenated phosphatidylcholine, shea butter, squalane and Ophiopogon japonicus root extract, mix and keep warm for 10-15 minutes; (3) Primary emulsification: Mix the water phase and the oil phase at 80±2°C and homogenize at 5000±1000 rpm for 5-8 minutes; (4) Nano-sizing: The primary emulsion was homogenized twice under a pressure of 1500 ± 200 Bar to obtain a liposome dispersion with a particle size of 180 ± 20 nm; (5) Cooling and filling: Cool the dispersion to 40±5℃, adjust the pH to 5.5-6.0 and then aseptically package.

[0014] Preferably, the high-pressure homogenizer in step (4) is a microfluidizer, and the homogenization temperature is 50-60°C.

[0015] The present invention provides a liquid cream for repairing skin through a lipid barrier and a cosmetic prepared therefrom. Compared with the prior art, it has the following advantages: (1) The liquid cream that repairs the skin through the lipid barrier and the cosmetics prepared therefrom, through lipid encapsulation technology and the biomimetic ratio of ceramide EOP:NS:AP=2:1:1, combined with the hydrogen bond stabilization effect of Ophiopogon root extract (0.05-0.5%), prevents crystallization and achieves a breakthrough in the stability of the active ingredient.

[0016] (2) The liquid cream that repairs the skin through the lipid barrier and the cosmetics prepared therefrom achieve nanoliposomes with a particle size of 185±15nm through a double homogenization process (high speed 5000rpm + high pressure 1500Bar), which significantly improves the transdermal absorption efficiency.

[0017] (3) The liquid cream that repairs the skin through the lipid barrier and the cosmetics prepared therefrom, through the biomimetic sebum ratio (ceramide + shea butter + squalane) to synergistically repair the stratum corneum lipid structure, so that the skin barrier repair effect is significant (4) The liquid cream that repairs the skin through the lipid barrier and the cosmetics prepared therefrom are suitable for sensitive skin through phosphorus-free and non-irritating emulsifiers and pH 5.5-6.0; hydrogenated phosphatidylcholine (1-5%) directional arrangement of the lipid layer reduces the complexity of the formula and achieves safety and compatibility advantages. (5) The liquid cream for repairing the skin through the lipid barrier and the cosmetics prepared therefrom can be adapted to different dosage forms by adjusting the emollient ratio (5-15%) and homogenization parameters, thereby achieving flexible adaptation to multiple dosage forms. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Flow chart of the method for preparing the structure of the present invention. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present invention are clearly and completely described. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0020] See also Figure 1 The embodiment of the present invention provides a technical solution: a liquid cream for repairing skin through a lipid barrier, comprising the following components by mass percentage: Moisturizer 1-30%, lecithin 0.1-2%, preservative 0.5-3%, emollient 5-15%, ceramide 0.1-1%, shea butter 1-10%, squalane 0.5-8%, hydrogenated phosphatidylcholine 1-5%, ophiopogon root extract 0.05-0.5%, and the balance is deionized water.

[0021] Furthermore, the moisturizing agent includes at least two of glycerin, butylene glycol, dipropylene glycol, methylpropanediol, propylene glycol and 1.3 propanediol.

[0022] Furthermore, the lecithin is a compound of soybean lecithin and lysophosphatidylcholine, and the compounding ratio is 2:1-4:1.

[0023] Furthermore, the preservative is composed of hexylene glycol and phenoxyethanol in a ratio of 1:1-3:1.

[0024] Furthermore, the emollient is selected from at least two of caprylic / capric triglyceride, glyceryl tri(ethylhexanoate), and octyldodecanol.

[0025] Furthermore, the ceramide comprises ceramide EOP, ceramide NS, and ceramide AP, and the molar ratio of the three is 1.5:1:1-2.5:1:1.

[0026] A cosmetic for repairing skin through a lipid barrier, the cosmetic comprising a composition, wherein the cosmetic is an essence, an emulsion, a cream or a mask, and has a pH value of 5.0-6.5.

[0027] Example 1: Essence (Lipid Barrier Repair Essence) Formula composition (mass percentage):

[0028]

[0029] Preparation method Aqueous phase preparation: Glycerol, 1,3-propylene glycol, soy lecithin, lysolecithin, hexylene glycol, and phenoxyethanol were added to a reactor, heated to 85°C, and stirred (200 rpm) until completely dissolved (approximately 25 minutes).

[0030] Oil phase preparation: Mix ceramides EOP, NS, and AP with caprylic / capric triglyceride and triethylhexanoin, and heat to 95°C until the ceramides are completely dissolved.

[0031] Add hydrogenated phosphatidylcholine, shea butter, squalane and Ophiopogon japonicus root extract and stir for 15 minutes.

[0032] Primary emulsification: The oil phase was slowly added to the water phase (80°C) and homogenized at 5000 rpm for 6 minutes to form a primary emulsion.

[0033] High-pressure nanomaterials: The primary emulsion was homogenized twice by a microfluidizer (1500 Bar, 55 °C) to obtain a nanoliposome dispersion with a particle size of 185 ± 15 nm.

[0034] Repackaging: Cool to 40°C, adjust the pH to 5.8, and aseptically fill into a transparent essence.

[0035] Technical Data

[0036] Example 2: Lotion (Light Barrier Repair Lotion) Recipe adjustment (mass percentage)

[0037] Preparation method adjustment Step 4: High-pressure homogenization: The pressure was adjusted to 1400 Bar, and homogenization was performed twice, with a particle size of 195 ± 20 nm.

[0038] Step 5: Packaging: Adjust the pH to 5.5 and fill as an emulsion.

[0039] Technical Data

[0040] Example 3: Face Cream (High Moisturizing Barrier Repair Cream) Recipe adjustment (mass percentage)

[0041] Preparation method adjustment Step 3: Primary emulsification: increase the homogenization speed to 6000 rpm for 8 minutes.

[0042] Step 4: High-pressure homogenization: pressure 1600 Bar, particle size 210 ± 25 nm (still within ≤ 200 nm) Technical Data

[0043] Example 4: Facial Mask (Quick-Acting Hydrating Repairing Mask) Recipe adjustment (mass percentage)

[0044] Preparation method adjustment Step 5: Packaging: Soak the dispersion into non-woven mask cloth, each piece contains 25g of essence.

[0045] Technical Data

[0046] The beneficial effects of the present invention are as follows: 1. Significantly improve ceramide stability Through lipid encapsulation technology (particle size ≤ 200nm) and a specific molar ratio formula (ceramide EOP:NS:AP=2:1:1), ceramide crystallization is effectively prevented.

[0047] Experimental data: After storage at 25°C for 6 months, the ceramide retention rate is ≥95% (Example 1), and the retention rate in the 40°C accelerated test is ≥90% (Example 2).

[0048] 2. Enhance transdermal absorption efficiency Nanoliposomes (185±15nm) significantly improved the permeability of active ingredients, with the cumulative transdermal amount of ceramide reaching 98.3μg / cm² in 24 hours, which is 2.3 times that of commercially available products (Example 3).

[0049] 3. Optimize skin barrier repair effect After 28 days, the water content of the stratum corneum increased by 45% and the transepidermal water loss (TEWL) decreased by 58%; The erythema index decreased by 40%, confirming the dual effects of anti-inflammatory and barrier repair.

[0050] 4. Formula simplification and safety Through the synergistic effect of biomimetic sebum ratio (ceramide + shea butter + squalane) and Ophiopogon root extract, no complex emulsifiers are needed: The peroxide value only increases by 30% in 6 months (0.5→0.65meq / kg), which is far below the industry limit (1.0meq / kg); it contains no irritating ingredients and has a pH of 5.0-6.5, making it suitable for sensitive skin.

[0051] 5. Compatibility with multiple dosage forms The same technology platform can be flexibly adjusted to essence, lotion, cream, and mask (Examples 1-4), all maintaining: Nanoliposome structural integrity (particle size 180-210nm) and efficient delivery of core active ingredients.

[0052] Therefore, the process breakthrough: double homogenization (high speed + high pressure) enables large-scale production of small-particle liposomes; Component synergy: The polyhydroxy structure of Ophiopogon root extract stabilizes liposomes and assists in moisturizing; Bionic design: The molar ratio accurately simulates the natural sebum film to improve skin affinity.

[0053] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0054] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A liquid cream for repairing skin through lipid barrier, characterized in that: The following components are included by mass percentage: Moisturizer 1-30%, lecithin 0.1-2%, preservative 0.5-3%, emollient 5-15%, ceramide 0.1-1%, shea butter 1-10%, squalane 0.5-8%, hydrogenated phosphatidylcholine 1-5%, ophiopogon root extract 0.05-0.5%, and the balance is deionized water.

2. The liquid facial cream for repairing skin through lipid barrier according to claim 1, characterized in that: The moisturizing agent includes at least two of glycerin, butylene glycol, dipropylene glycol, methylpropanediol, propylene glycol and 1.3 propanediol.

3. The liquid facial cream for repairing skin through lipid barrier according to claim 1, characterized in that: The lecithin is a compound of soybean lecithin and lysophosphatidylcholine, and the compounding ratio is 2:1-4:

1.

4. The liquid facial cream for repairing skin through lipid barrier according to claim 1, characterized in that: The preservative is composed of hexylene glycol and phenoxyethanol in a ratio of 1:1-3:

1.

5. The liquid facial cream for repairing skin through lipid barrier according to claim 1, characterized in that: The emollient is selected from at least two of caprylic / capric triglyceride, glyceryl tri(ethylhexanoate), and octyldodecanol.

6. The liquid facial cream for repairing skin through lipid barrier according to claim 1, characterized in that: The ceramide comprises ceramide EOP, ceramide NS, and ceramide AP, and the molar ratio of the three is 1.5:1:1-2.5:1:

1.

7. A cosmetic for repairing skin through lipid barrier, characterized by: The cosmetic comprises the composition according to any one of claims 1 to 6, wherein the cosmetic consists of the composition.

8. The cosmetic for repairing skin through lipid barrier according to claim 7, characterized in that: The cosmetics are essence, lotion, cream or mask, and have a pH value of 5.0-6.

5.

9. A method for preparing the composition according to claim 1, characterized in that The following steps are involved: (1) Preparation of aqueous phase: Stir and disperse the moisturizer, lecithin, and preservative at 85±5°C for 20-30 minutes to form a uniform transparent liquid; (2) Preparation of oil phase: Heat ceramide and emollient at 95±2℃ until completely dissolved, add hydrogenated phosphatidylcholine, shea butter, squalane and Ophiopogon japonicus root extract, mix and keep warm for 10-15 minutes; (3) Primary emulsification: Mix the water phase and the oil phase at 80±2°C and homogenize at 5000±1000 rpm for 5-8 minutes; (4) Nano-sizing: The primary emulsion was homogenized twice under a pressure of 1500 ± 200 Bar to obtain a liposome dispersion with a particle size of 180 ± 20 nm; (5) Cooling and filling: Cool the dispersion to 40±5℃, adjust the pH to 5.5-6.0 and then aseptically package.

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