A method and system for precise delivery of intraoral liquid drugs

Abstract

This invention relates to the field of precise intraoral liquid drug delivery technology, and more particularly to a method and system for precise intraoral liquid drug delivery, comprising: fixing a nozzle to a target delivery area; acquiring relevant gas flow velocities within the oral cavity to determine a gas flow velocity distribution area; locating the target delivery range, determining a spraying speed based on the intersection of the gas flow velocity distribution area and the target delivery range, and the risk of coughing from the liquid drug; determining a loss adjustment method based on the relationship between the target delivery range and the gas flow velocity distribution area, including adjusting the spraying frequency, or adjusting the radiant power density of the curing light based on the distribution area of ​​the drug in non-target delivery areas; and completing drug delivery according to the adjusted spraying speed or loss adjustment method. This invention, by acquiring images and relevant gas flow velocities within the oral cavity, enables adjusted drug delivery under environmental influences or loss conditions, thereby improving the accuracy of drug delivery.

Description

Technical Field

[0001] This invention relates to the field of liquid drug delivery technology, and in particular to a method and system for precise intraoral liquid drug delivery. Background Technology

[0002] The development of a precise intraoral liquid drug delivery method and system improves the accuracy of drug delivery by acquiring images and relevant gas flow rates within the oral cavity, enabling adjustments to the delivery of liquid drugs even under environmental influences or losses. The micro-supply of liquid drugs after data and image acquisition, as well as the adjustment of spray speed and frequency, solves the problem of precise dosage and time control that is difficult to achieve with traditional drug delivery methods.

[0003] In the prior art, Chinese Patent Publication No. CN109908461A discloses an oral drug delivery device and its preparation method and application, comprising: the oral drug delivery device includes a fixed mechanism and a movable mechanism, the fixed mechanism and the movable mechanism being connected to each other by magnetic force or a snap-fit ​​structure; the fixed mechanism is fixed to a denture, dental braces, or dental implant; and a drug layer is disposed within the movable mechanism. The oral drug delivery device of the present invention has a simple structure, and when drug delivery is needed, the movable mechanism can be firmly installed on the fixed mechanism at any time, allowing the release of active substances such as drugs to achieve therapeutic and / or health care functions, and prolonging the residence time of the preparation on the mucosal surface; drug delivery can be terminated by disassembling the movable mechanism from the fixed mechanism by external force. Therefore, while the oral drug delivery device and its preparation method and application achieve drug release by setting a drug layer within the movable mechanism, they also have problems such as uneven drug flow rate in the target drug delivery area within the oral cavity leading to coughing, a single drug delivery method, excessive gas flow rate in the target drug delivery area, and the expansion and contraction of oral tissues causing the spray position of liquid drugs to deviate, resulting in decreased drug delivery accuracy. Summary of the Invention

[0004] Therefore, the present invention provides a method and system for precise intraoral liquid drug delivery, which overcomes the problems in the prior art where uneven drug flow rate in the target drug delivery area leads to choking, the single drug delivery method, excessive gas flow rate in the target drug delivery area, and the expansion and contraction of oral tissues causing the liquid drug spray position to deviate, thus resulting in decreased drug delivery accuracy.

[0005] On one hand, the present invention provides an intraoral liquid drug precision delivery system, comprising:

[0006] Medicine storage box, used to store liquid medicines;

[0007] The spraying module, which is connected to the drug storage box, is used to deliver the liquid drug to the target drug delivery area in the oral cavity. It includes a micro pump for providing the delivery power of the liquid drug, a drug delivery tube connected to the micro pump, a fixing part fixedly connected to the drug delivery tube to define the release position of the liquid drug, and a nozzle connected to the drug delivery tube for spraying the drug onto the target drug delivery area.

[0008] A light-curing module, which is located outside the oral cavity, cures the fixation part by irradiating it with light, including an infrared lamp and an ultraviolet lamp;

[0009] The detection module, which is connected to the spraying module, is used to acquire the gas flow rate above the target drug delivery area, several gas flow rates in the non-target drug delivery area inside the oral cavity, and surface images of the target drug delivery area before and after spraying.

[0010] A control module, connected to the spraying module, the detection module, and the light curing module, is used to determine the gas velocity distribution in the oral cavity based on several gas velocities in the non-target drug delivery area and the gas velocity above the target drug delivery area; determine the spraying speed of the nozzle based on the gas velocity distribution and the choking risk value of the liquid drug; determine the spraying frequency based on the gas velocity distribution and the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area; and adjust the radiant power density of the curing light based on the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area in the non-target drug delivery area.

[0011] Furthermore, the detection module includes:

[0012] An airflow sensor, which is installed on the drug delivery tube, is used to detect the gas flow rate in the target drug delivery area and several gas flow rates in the non-target drug delivery areas of the oral cavity;

[0013] A camera, mounted on the fixed part, is used to acquire surface images of the target drug delivery area before and after spraying.

[0014] Furthermore, the control module is connected to the airflow sensor and the camera respectively, to acquire the surface image of the target drug delivery area before spraying and the gas flow velocity above the target drug delivery area and several gas flow velocities in non-target drug delivery areas, respectively. Based on the surface image of the target drug delivery area before spraying, the target drug delivery range is located; based on the gas flow velocity above the target drug delivery area and several gas flow velocities in the non-target drug delivery areas, the gas flow velocity distribution area is determined; and based on the target drug delivery range being a sub-region / intersection of the gas flow velocity distribution area, the spraying speed of the nozzle on the target drug delivery area in the oral cavity is increased.

[0015] The spraying speed of the nozzle is positively correlated with the gas flow rate above the target drug delivery area.

[0016] Furthermore, the largest planar closed region formed by connecting the corresponding sampling points that satisfy the gas flow velocity condition is defined as the gas flow velocity distribution region.

[0017] The gas flow rate condition is that the gas flow rate at each corresponding sampling point in the non-target drug delivery area and the target drug delivery area is greater than a preset gas flow rate.

[0018] Furthermore, the control module is connected to the camera and is used to determine the liquid drug distribution area of ​​the target drug delivery area after spraying based on the surface image of the target drug delivery area, provided that there is no intersection between the target drug delivery range and the gas flow rate distribution area. If the liquid drug distribution area of ​​the target drug delivery area after spraying is less than a preset first distribution area, it is determined that the degree of drug loss does not meet the requirements, and the spraying frequency is increased.

[0019] The spraying frequency is negatively correlated with the distribution area of ​​the drug in the target drug delivery area after spraying.

[0020] Furthermore, the control module is connected to the infrared lamp and the ultraviolet lamp respectively, and is used to initially determine that the curing degree of the fixing part does not meet the requirements based on the distribution area of ​​liquid drug in the target drug delivery area being greater than or equal to the preset first distribution area and less than or equal to the preset second distribution area. It also obtains the distribution area of ​​liquid drug in the non-target drug delivery area, and further determines that the curing degree of the fixing part does not meet the requirements based on the distribution area of ​​drug in the non-target drug delivery area being greater than the preset distribution area, and increases the radiation power density of the curing light.

[0021] Wherein, the radiation power density of the curing light is positively correlated with the distribution area of ​​the drug in the non-target drug delivery area; the preset first distribution area is smaller than the preset second distribution area.

[0022] Furthermore, the control module is connected to both the camera and the micro-pump, and is used to extract the flow velocity of the liquid drug on the surface of the target drug delivery area and the expansion and contraction characteristics of the oral tissue in the target drug delivery area based on several frames of surface images of the target drug delivery area after spraying. It then calculates a coughing risk value based on the flow velocity of the liquid drug on the surface of the target drug delivery area and the expansion and contraction characteristics of the oral tissue in the target drug delivery area, and reduces the spraying speed if the coughing risk value exceeds a preset risk value.

[0023] The reduced spraying speed is negatively correlated with the cough risk value.

[0024] Furthermore, the coughing risk value is the sum of the product of the flow velocity of the liquid drug on the surface of the target drug delivery area and the flow velocity weighting coefficient, and the product of the stretching characteristic parameter of the oral tissue in the target drug delivery area and the stretching characteristic parameter weighting coefficient.

[0025] The sum of the flow velocity weighting coefficient and the stretching characteristic parameter weighting coefficient is 1.

[0026] Furthermore, the stretching characteristic parameter is the sum of the product of the stretching velocity of the oral tissue in the target drug delivery area and its weighting coefficient, and the product of the total length of the stretching interruption and its weighting coefficient.

[0027] The sum of the weighting coefficient of the telescopic speed and the weighting coefficient of the total length of the telescopic interruption is 1.

[0028] On the other hand, the present invention also provides a method for precise administration of intraoral liquid drugs, comprising:

[0029] Secure the nozzle to the target drug delivery area;

[0030] Obtain the gas flow rate above the target drug delivery area and several gas flow rates in non-target drug delivery areas;

[0031] The target drug delivery range is located based on the surface image of the target drug delivery area before spraying.

[0032] The gas velocity distribution area is determined based on the gas velocity above the target drug delivery area and several gas velocities in the non-target drug delivery area;

[0033] The spraying speed of the nozzle is determined based on the overlapping area between the gas flow velocity distribution area and the target drug delivery range, as well as the coughing risk value of the liquid drug.

[0034] The loss adjustment method is determined based on the absence of an intersection between the target drug delivery range and the gas flow rate distribution area, including adjusting the spraying frequency, or adjusting the radiation power density of the curing light based on the distribution area of ​​the liquid drug in the non-target drug delivery area.

[0035] The target drug delivery area is actually sprayed according to the adjusted spraying speed or the adjusted loss method to complete the drug delivery process.

[0036] Compared with the prior art, the beneficial effects of the present invention are as follows: The present invention determines the gas velocity distribution in the oral cavity based on several gas velocity rates in non-target drug delivery areas and the gas velocity above the target drug delivery area, and determines the nozzle spray speed based on the gas velocity distribution and the cough risk value of the liquid drug. When administering medication to the target drug delivery area in the oral cavity, due to the continuous breathing process in the oral cavity and the inconsistent gas velocity distribution in each oral cavity, when the gas velocity exceeds the preset gas velocity and there is an overlap between the target drug delivery area and the area exceeding the preset gas velocity, the gas flow in the oral cavity can interfere with the drug delivery position in the target drug delivery area. Therefore, by increasing the spray speed, the influence of gas flow on the drug delivery position is overcome, thereby improving the accuracy of drug delivery. When the drug delivery speed is too high, it will lead to an increased risk of coughing. Therefore, by determining the gas velocity distribution based on the gas velocity distribution and the cough risk value of the liquid drug, the spray speed is determined. The flow velocity of the drug on the surface of the target administration area and the stretching characteristic parameters of the oral tissue in the target administration area are used to predict the cough risk value. Based on the cough risk value, the spraying speed is appropriately reduced while increasing the spraying speed to achieve a balance between drug administration accuracy and cough risk, thereby improving spraying safety. The liquid drug distribution area of ​​the target administration area after spraying is obtained based on the absence of an intersection between the target administration range and the gas velocity distribution area. If the liquid drug distribution area of ​​the target administration area after spraying is less than a preset first distribution area, it indicates that during the spraying process, the gas velocity distribution area interferes with the nozzle's spraying of the drug into the target administration area, causing some liquid drug to not fall within the target administration range, resulting in unsatisfactory liquid drug loss. Increasing the spraying frequency enables quantitative spraying of the drug within the target administration range, thereby reducing spraying loss.

[0037] Furthermore, the present invention acquires in real time the gas flow rate of the target drug delivery area in the oral cavity and several gas flow rates of non-target drug delivery areas in the oral cavity, as well as surface images of the target drug delivery area before and after spraying, by setting an airflow sensor and a camera in the detection module, providing data support for subsequent drug delivery speed, frequency and adjustment of the fixing part.

[0038] Furthermore, the present invention determines the gas velocity distribution area based on the gas velocity above the target drug delivery area and several gas velocities in the non-target drug delivery area, and increases the spraying speed according to the sub-regions / intersections of the gas velocity distribution area where the target drug delivery range is located, so as to reduce the interference of airflow when the target drug delivery range is in the sub-regions / intersections of the gas velocity distribution area during spraying, thereby achieving accurate drug delivery to the target drug delivery area.

[0039] Furthermore, the present invention sets up a control module connected to the infrared lamp and the ultraviolet lamp respectively. Based on the fact that the distribution area of ​​the liquid drug is greater than or equal to the preset first distribution area and less than or equal to the preset second distribution area, it is initially determined that the degree of curing does not meet the requirements. The distribution area of ​​the liquid drug in the non-target drug delivery area is obtained. Based on the fact that the distribution area of ​​the drug in the non-target drug delivery area is greater than the preset distribution area of ​​the drug in the non-drug delivery area, the radiation power density of the curing light is increased, thereby making the spraying position of the drug more precise. Attached Figure Description

[0040] Figure 1 This is a schematic diagram of the overall structure of the oral liquid drug precision delivery system according to an embodiment of the present invention;

[0041] Figure 2-1 This is a schematic diagram showing the relationship between the target drug delivery range, the target drug delivery area, and the location of the gas flow rate sampling point in the oral liquid drug precision delivery system according to an embodiment of the present invention.

[0042] Figure 2-2 This is a schematic diagram showing the positional relationship between the projection surface of the target drug delivery range and the projection surface of the target drug delivery area, as well as the two-dimensional plane, of the oral liquid drug precision delivery system according to an embodiment of the present invention.

[0043] Figure 3 This is a block diagram of the overall structure of the oral liquid drug precision delivery system according to an embodiment of the present invention;

[0044] Figure 4 This is an overall flowchart of the method for precise intraoral liquid drug delivery according to an embodiment of the present invention;

[0045] Explanation of reference numerals in the attached drawings: 1-fixed part, 2-drug storage box, 3-micro pump, 4-drug delivery tube, 5-camera, 6-nozzle, 7-airflow sensor, 8-two-dimensional plane, 9-gas flow rate sampling point, 10-target drug delivery area, 11-target drug delivery range, 12-projection surface of the target drug delivery area, 13-projection surface of the target drug delivery range. Detailed Implementation

[0046] To make the objectives and advantages of the present invention clearer, the present invention will be further described below with reference to embodiments; it should be understood that the specific embodiments described herein are merely for explaining the present invention and are not intended to limit the present invention.

[0047] Preferred embodiments of the present invention will now be described with reference to the accompanying drawings. Those skilled in the art should understand that these embodiments are merely illustrative of the technical principles of the present invention and are not intended to limit the scope of protection of the present invention.

[0048] It should be noted that in the description of this invention, the terms "upper", "lower", "left", "right", "inner", "outer", etc., which indicate the direction or positional relationship, are based on the direction or positional relationship shown in the drawings. This is only for the convenience of description and is not intended to indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of this invention.

[0049] Furthermore, it should be noted that, in the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0050] Please see Figure 1 , Figure 2-1 , Figure 2-2 , Figure 3 and Figure 4 The figures shown are, respectively, a schematic diagram of the overall structure of an intraoral liquid drug precision delivery system according to an embodiment of the present invention, a schematic diagram of the positional relationship between the target drug delivery range, the target drug delivery area, and the gas flow rate sampling point, a schematic diagram of the positional relationship between the projection surface of the target drug delivery range, the projection surface of the target drug delivery area, and the two-dimensional plane, an overall structural block diagram, and an overall flowchart of an intraoral liquid drug precision delivery method according to an embodiment of the present invention. An intraoral liquid drug precision delivery system according to an embodiment of the present invention includes:

[0051] Medicine storage box 2 is used to store liquid medicines;

[0052] The spraying module, which is connected to the drug storage box 2, is used to deliver the liquid drug to the target drug delivery area in the oral cavity. It includes a micro pump 3 for providing the delivery power of the liquid drug, a drug delivery tube 4 connected to the micro pump 3, a fixing part 1 fixedly connected to the drug delivery tube 4 to define the release position of the liquid drug, and a nozzle 6 connected to the drug delivery tube 4 for spraying the drug onto the target drug delivery area.

[0053] A light curing module is installed outside the oral cavity. It cures the fixation part 1 by irradiating it with light, including an infrared lamp and an ultraviolet lamp.

[0054] The detection module, which is connected to the spraying module, is used to acquire the gas flow rate above the target drug delivery area, several gas flow rates in the non-target drug delivery area inside the oral cavity, and surface images of the target drug delivery area before and after spraying.

[0055] A control module, connected to the spraying module, the detection module, and the light curing module, is used to determine the gas velocity distribution in the oral cavity based on several gas velocities in the non-target drug delivery area and the gas velocity above the target drug delivery area; determine the spraying speed of nozzle 6 based on the gas velocity distribution and the choking risk value of the liquid drug; determine the spraying frequency based on the gas velocity distribution and the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area; and adjust the radiant power density of the curing light based on the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area in the non-target drug delivery area.

[0056] Specifically, the actual application of the infrared lamp and the ultraviolet lamp is to first use the infrared lamp for preheating and preliminary curing, and then use the ultraviolet lamp for rapid surface curing.

[0057] Specifically, the detection module includes:

[0058] An airflow sensor 7 is disposed on the drug delivery tube 4 to detect the gas flow rate in the target drug delivery area and several gas flow rates in the non-target drug delivery areas of the oral cavity, respectively.

[0059] Camera 5, which is mounted on the fixed part 1, is used to acquire surface images of the target drug delivery area before and after spraying.

[0060] Specifically, the area above the target drug delivery area is vertically above the horizontal plane of the target drug delivery area.

[0061] In practice, the present invention uses an airflow sensor 7 and a camera 5 in the detection module to acquire in real time the gas flow rate of the target drug delivery area in the oral cavity and several gas flow rates of the non-target drug delivery areas in the oral cavity, as well as surface images of the target drug delivery area before and after spraying, so as to provide data support for subsequent drug delivery speed, frequency and adjustment of the fixing part 1.

[0062] Specifically, camera 5 can be a miniature high-resolution camera.

[0063] Specifically, the control module is connected to the airflow sensor 7 and the camera 5, respectively, to acquire the surface image of the target drug delivery area before spraying and the gas flow velocity above the target drug delivery area and several gas flow velocities in non-target drug delivery areas. Based on the surface image of the target drug delivery area before spraying, the target drug delivery range is located; based on the gas flow velocity above the target drug delivery area and several gas flow velocities in the non-target drug delivery areas, the gas flow velocity distribution area is determined; and based on the target drug delivery range being a sub-region / intersection of the gas flow velocity distribution area, the spraying speed of the nozzle 6 on the target drug delivery area in the oral cavity is increased.

[0064] The spraying speed of the nozzle 6 is positively correlated with the gas flow rate above the target drug delivery area.

[0065] In practice, this invention determines the gas velocity distribution in the oral cavity based on several gas velocity rates in non-target drug delivery areas and the gas velocity above the target drug delivery area. It also determines the spraying speed of nozzle 6 based on the gas velocity distribution and the risk of choking on the liquid drug. When administering medication to the target drug delivery area in the oral cavity, due to the continuous breathing process and inconsistent gas velocity distribution within each oral cavity, gas flow can interfere with the delivery location of the target drug delivery area when the gas velocity exceeds a preset gas velocity and the target drug delivery area intersects with areas exceeding the preset gas velocity. Therefore, increasing the spraying speed overcomes the influence of gas flow on the delivery location, thereby improving the accuracy of drug delivery.

[0066] Specifically, the largest planar closed region formed by connecting the corresponding sampling points that meet the gas flow velocity conditions is defined as the gas flow velocity distribution region.

[0067] The gas flow rate condition is that the gas flow rate at each corresponding sampling point in the non-target drug delivery area and the target drug delivery area is greater than a preset gas flow rate.

[0068] Please see Figure 2-1 or Figure 2-2 As shown, a specific embodiment is as follows:

[0069] A region with a radius of 15 mm, centered on the target drug delivery range 11, is defined as the target drug delivery area. The target drug delivery area is projected onto a two-dimensional plane 8 between the target drug delivery area and the nozzle 6, serving as the projection surface 12 of the target drug delivery area. The target drug delivery range 11 is projected onto the two-dimensional plane 8 between the target drug delivery area and the nozzle 6, serving as the projection surface 13 of the target drug delivery range. The area within the two-dimensional plane 8 excluding the projection surface 12 of the target drug delivery area is defined as the projection surface of the non-target drug delivery area.

[0070] Among them, several gas velocity sampling points 9 are set at equal intervals on the two-dimensional plane 8, and the spraying speed of the nozzle 6 is determined by whether there is an intersection between the projection surface 13 of the target drug delivery range and the gas velocity distribution area.

[0071] Specifically, the greater the difference between the gas flow rate and the standard gas flow rate, the faster the spraying speed.

[0072] Optionally, the standard gas flow rate can be selected within the range of [0.5 m / s, 2.0 m / s];

[0073] Preferably, the standard gas flow rate is 1.0 m / s in the preferred embodiment;

[0074] During implementation, when the gas flow rate exceeds the standard gas flow rate by less than 10%, the spraying speed is adjusted to 1.2 times the current spraying speed. For every 5% exceeding 10%, the spraying speed is increased by 0.1 times.

[0075] Deviation less than or equal to 10%: spraying speed × 1.2;

[0076] If the deviation is greater than 10%, calculate the spraying speed as (1.2 + (deviation value / 5) × 0.1).

[0077] The deviation value is the difference between the current gas flow rate and the standard gas flow rate.

[0078] For example, when the gas flow rate is 1.1 m / s, the current spraying rate is 5 ml / s, and the increased spraying rate is 6 ml / s;

[0079] When the gas flow rate is 1.2 m / s, the current spraying speed is 5 ml / s, and the increased spraying speed is 6.5 ml / s.

[0080] Specifically, the control module is connected to the camera 5 and is used to determine the liquid drug distribution area of ​​the target drug delivery area after spraying based on the surface image of the target drug delivery area, provided that there is no intersection between the target drug delivery range and the gas flow rate distribution area. If the liquid drug distribution area of ​​the target drug delivery area after spraying is less than a preset first distribution area, it is determined that the degree of drug loss does not meet the requirements, and the spraying frequency is increased.

[0081] The spraying frequency is negatively correlated with the distribution area of ​​the drug in the target drug delivery area after spraying.

[0082] In practice, the liquid drug distribution area of ​​the target drug delivery area after spraying is obtained based on the absence of an intersection between the target drug delivery area and the gas velocity distribution area. If the liquid drug distribution area of ​​the target drug delivery area after spraying is less than a preset first distribution area, it indicates that during the spraying process, the gas velocity distribution area interferes with the spraying of the target drug delivery area from the nozzle 6, causing some of the liquid drug to not fall within the target drug delivery area, resulting in a liquid drug loss that does not meet the requirements. Therefore, the spraying frequency is increased to achieve quantitative spraying of the drug within the target drug delivery area, thereby reducing spraying loss.

[0083] Specifically, the control module is connected to both the infrared lamp and the ultraviolet lamp. It is used to initially determine that the curing degree of the fixing part 1 does not meet the requirements based on the distribution area of ​​the liquid drug in the target drug delivery area being greater than or equal to a preset first distribution area and less than or equal to a preset second distribution area. It also obtains the distribution area of ​​the liquid drug in the non-target drug delivery area. Based on the fact that the distribution area of ​​the drug in the non-target drug delivery area is greater than a preset distribution area, it further determines that the curing degree of the fixing part 1 does not meet the requirements and increases the radiation power density of the curing light.

[0084] Wherein, the radiation power density of the curing light is positively correlated with the distribution area of ​​the drug in the non-target drug delivery area; the preset first distribution area is smaller than the preset second distribution area.

[0085] In implementation, this invention sets up a control module connected to the infrared lamp and the ultraviolet lamp respectively. Based on the fact that the distribution area of ​​the liquid drug is greater than or equal to the preset first distribution area and less than or equal to the preset second distribution area, it is initially determined that the degree of curing does not meet the requirements. The distribution area of ​​the liquid drug in the non-target drug delivery area is obtained. Based on the fact that the distribution area of ​​the drug in the non-target drug delivery area is greater than the preset distribution area of ​​the drug in the non-drug delivery area, the radiation power density of the curing light is increased, thereby making the spraying position of the drug more precise.

[0086] Specifically, in this embodiment, the fixing part 1 is made of medical photocurable resin.

[0087] Optionally, medical photocurable resins use UVA wavelengths of 365 nm or 395 nm.

[0088] Preferably, when processing thick photocurable resin materials, the 365 nm wavelength has strong penetrating power and is suitable for curing thicker materials.

[0089] Optionally, the near-infrared wavelength range is [800nm, 1000 nm], which is often used for curing medical materials.

[0090] Specifically, the control module is connected to both the camera 5 and the micro-pump 3. It extracts the flow velocity of the liquid drug on the surface of the target drug delivery area and the expansion and contraction characteristics of the oral tissue in the target drug delivery area from several frames of surface images of the target drug delivery area after spraying. Based on these parameters, it calculates a coughing risk value and reduces the spraying speed if the coughing risk value exceeds a preset risk value.

[0091] The reduced spraying speed is negatively correlated with the cough risk value.

[0092] Specifically, by extracting the changes in the surface of the target drug delivery area in each frame after spraying, several feature points are selected on the surface of the liquid drug and oral tissue in the target drug delivery area. Several flow velocities and several expansion velocities of the liquid drug and oral tissue in each frame on the surface of the target drug delivery area are calculated. The average value of several flow velocities and several expansion velocities of all feature points is taken to obtain the flow velocity and expansion velocity of the liquid drug and oral tissue on the surface of the target drug delivery area.

[0093] Preferably, in this invention, a preset cough risk value is set to 1.5.

[0094] In practice, this invention addresses the issue that excessive drug delivery speed can increase the risk of choking. Therefore, it predicts the choking risk value based on the flow rate of the liquid drug on the surface of the target drug delivery area and the stretching characteristics of the oral tissue in the target drug delivery area. Based on the choking risk value, the spraying speed is appropriately reduced while increasing the spraying speed to achieve a balance between drug delivery accuracy and choking risk, thereby improving the safety of drug delivery.

[0095] Specifically, the coughing risk value is the sum of the product of the flow velocity of the liquid drug on the surface of the target drug delivery area and the flow velocity weighting coefficient, and the product of the stretching characteristic parameter of the oral tissue in the target drug delivery area and the stretching characteristic parameter weighting coefficient.

[0096] Specifically, the sum of the flow velocity weighting coefficient and the stretching characteristic parameter weighting coefficient is 1.

[0097] Specifically, the stretching characteristic parameter is the sum of the product of the stretching speed of the oral tissue in the target drug delivery area and its weighting coefficient, and the product of the total length of the stretching interruption and its weighting coefficient.

[0098] The sum of the weighting coefficient of the telescopic speed and the weighting coefficient of the total length of the telescopic interruption is 1.

[0099] Specifically, the total length of the stretching interruption is the sum of the lengths of the oral tissue with a stretching length of 0 in the target drug delivery area; the length of the oral tissue with a stretching length of 0 is the length of the segment of oral tissue with a stretching length of 0 in the stretching direction.

[0100] A specific example is as follows:

[0101] The current flow velocity is 2 mm / s, the flow velocity weighting coefficient is 0.6, the expansion velocity is 1 mm / s, the expansion velocity weighting coefficient is 0.5, the total length of the expansion interruption is 3 mm, the total length of the expansion interruption weighting coefficient is 0.5, and the expansion characteristic parameter weighting coefficient is 0.4.

[0102] The stretching characteristic parameter of the oral tissue in the target drug delivery area is: 1×0.5+3×0.5=2.0;

[0103] The coughing risk value is: 2×0.6+2×0.4=2.0. Since 2.0 is greater than the preset coughing risk value of 1.5 in this embodiment, the spraying speed should be reduced.

[0104] Specifically, in practice, when the cough risk value exceeds the preset cough risk value by less than 0.15, the spraying speed is adjusted to 0.9 times the current spraying speed. For every 0.075 exceeding 0.15, the current spraying speed is reduced by 10%.

[0105] When the cough risk value exceeds the preset cough risk value by less than or equal to 0.15: spraying speed × 0.9;

[0106] When the cough risk value exceeds the preset cough risk value by more than 0.15: spraying speed × (0.9 + (deviation value / 5) × 0.1);

[0107] The deviation value is the difference between the current cough risk value and the preset cough risk value.

[0108] For example, when the cough risk value is 1.6, the current spraying rate is 5 ml / s, and the adjusted spraying rate is 4.5 ml / s;

[0109] For example, when the cough risk value is 2, the current spraying speed is 5 ml / s, and the adjusted spraying speed is 2.1 ml / s.

[0110] Please see Figure 4 As shown, an embodiment of the present invention provides a method for precise intraoral liquid drug delivery, comprising:

[0111] Secure nozzle 6 to the target drug delivery area;

[0112] Obtain the gas flow rate above the target drug delivery area and several gas flow rates in non-target drug delivery areas;

[0113] The target drug delivery range is located based on the surface image of the target drug delivery area before spraying.

[0114] The gas velocity distribution area is determined based on the gas velocity above the target drug delivery area and several gas velocities in the non-target drug delivery area;

[0115] The spraying speed of nozzle 6 is determined based on the overlapping area between the gas flow velocity distribution area and the target drug delivery range, as well as the coughing risk value of the liquid drug.

[0116] The loss adjustment method is determined based on the absence of an intersection between the target drug delivery range and the gas flow rate distribution area, including adjusting the spraying frequency, or adjusting the radiation power density of the curing light based on the distribution area of ​​the liquid drug in the non-target drug delivery area.

[0117] The target drug delivery area is actually sprayed according to the adjusted spraying speed or the adjusted loss method to complete the drug delivery process.

[0118] Work process:

[0119] Liquid medication is pre-stored in the medication storage box 2. The micro-pump 3, medication delivery tube 4, fixing part 1, and nozzle 6 are ready and awaiting activation. The airflow sensor 7 and camera 5 are activated to begin collecting environmental data within the oral cavity. The location and range of the target drug delivery area are determined by detecting the gas flow velocity above the target drug delivery area and in areas other than the target drug delivery area. Based on the image and gas flow velocity data, the gas flow velocity distribution area and the target drug delivery range are determined. The control module determines whether to adjust the spraying speed based on the relationship between the gas flow velocity distribution area and the target drug delivery range. If the target drug delivery range is a sub-region or intersection of the gas flow velocity distribution area, the spraying speed is increased. The control module calculates the cough risk value based on the flow velocity of the liquid medication on the surface of the target drug delivery area and the expansion and contraction characteristics of the oral tissue. If the cough risk value is greater than the preset cough risk value, the spraying speed is decreased. Based on the determined spraying speed and frequency, the liquid medication is sprayed onto the target drug delivery area. Based on the distribution area of ​​the liquid medication in areas other than the target drug delivery area, the radiation power density of the infrared and ultraviolet lamps is adjusted to solidify the medication. The system acquires surface images of the target drug delivery area after spraying and detects the distribution area of ​​the liquid drug. Based on the drug distribution area, it assesses the degree of drug loss and solidification. If the drug loss is insufficient, the spraying frequency is increased; if the solidification is insufficient, the radiant power density of the solidification light is increased. The system continuously monitors gas flow rate, drug distribution area, and cough risk value, dynamically adjusting the spraying speed, spraying frequency, and radiant power density of the solidification light based on real-time data. This ensures accurate drug delivery to the target area while minimizing drug loss and cough risk.

[0120] The technical solution of the present invention has been described above with reference to the preferred embodiments shown in the accompanying drawings. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will all fall within the scope of protection of the present invention.

Claims

1. An intraoral liquid drug delivery system, characterized in that, include: Medicine storage box, used to store liquid medicines; The spraying module, which is connected to the drug storage box, is used to deliver the liquid drug to the target drug delivery area in the oral cavity. It includes a micro pump for providing the delivery power of the liquid drug, a drug delivery tube connected to the micro pump, a fixing part fixedly connected to the drug delivery tube to define the release position of the liquid drug, and a nozzle connected to the drug delivery tube for spraying the drug onto the target drug delivery area. A light-curing module, which is located outside the oral cavity, cures the fixation part by irradiating it with light, including an infrared lamp and an ultraviolet lamp; The detection module, which is connected to the spraying module, is used to acquire the gas flow rate above the target drug delivery area, several gas flow rates in the non-target drug delivery area inside the oral cavity, and surface images of the target drug delivery area before and after spraying. A control module, which is connected to the spraying module, the detection module, and the light curing module, is used to determine the gas velocity distribution in the oral cavity based on several gas velocities in the non-target drug delivery area and the gas velocity above the target drug delivery area; determine the spraying speed of the nozzle based on the gas velocity distribution and the choking risk value of the liquid drug; determine the spraying frequency based on the gas velocity distribution and the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area; and adjust the radiation power density of the curing light based on the distribution area of ​​the liquid drug extracted from the surface image of the target drug delivery area in the non-target drug delivery area. The detection module includes: An airflow sensor is installed on the drug delivery tube to detect the gas flow rate in the target drug delivery area and several gas flow rates in the non-target drug delivery areas of the oral cavity, respectively. A camera, which is mounted on the fixed part, is used to acquire surface images of the target drug delivery area before and after spraying; The control module is connected to the airflow sensor and the camera, respectively, to acquire the surface image of the target drug delivery area before spraying and the gas flow velocity above the target drug delivery area and several gas flow velocities in non-target drug delivery areas. Based on the surface image of the target drug delivery area before spraying, the target drug delivery range is located; based on the gas flow velocity above the target drug delivery area and several gas flow velocities in the non-target drug delivery areas, the gas flow velocity distribution area is determined; and based on the target drug delivery range being a sub-region / intersection of the gas flow velocity distribution area, the spraying speed of the nozzle on the target drug delivery area in the oral cavity is increased. The spraying speed of the nozzle is positively correlated with the gas flow rate above the target drug delivery area; The largest planar closed region formed by connecting the corresponding sampling points that meet the gas flow velocity conditions is defined as the gas flow velocity distribution region, wherein... The gas flow rate condition is that the gas flow rate at each corresponding sampling point in the non-target drug delivery area and the target drug delivery area is greater than a preset gas flow rate.

2. The intraoral liquid drug delivery system according to claim 1, characterized in that, The control module is connected to the camera and is used to determine the liquid drug distribution area of ​​the target drug delivery area after spraying based on the surface image of the target drug delivery area, assuming that there is no intersection between the target drug delivery range and the gas flow rate distribution area. If the liquid drug distribution area of ​​the target drug delivery area after spraying is less than a preset first distribution area, it is determined that the degree of drug loss does not meet the requirements, and the spraying frequency is increased. The spraying frequency is negatively correlated with the distribution area of ​​the drug in the target drug delivery area after spraying.

3. The intraoral liquid drug delivery system according to claim 2, characterized in that, The control module is connected to both the infrared lamp and the ultraviolet lamp. It is used to initially determine that the curing degree of the fixation part does not meet the requirements based on the distribution area of ​​the liquid drug in the target drug delivery area being greater than or equal to a preset first distribution area and less than or equal to a preset second distribution area. It also obtains the distribution area of ​​the liquid drug in the non-target drug delivery area. If the distribution area of ​​the drug in the non-target drug delivery area is greater than a preset distribution area, it further determines that the curing degree of the fixation part does not meet the requirements and increases the radiation power density of the curing light. Wherein, the radiation power density of the curing light is positively correlated with the distribution area of ​​the drug in the non-target drug delivery area; the preset first distribution area is smaller than the preset second distribution area.

4. The intraoral liquid drug delivery system according to claim 3, characterized in that, The control module is connected to both the camera and the micro-pump. It is used to extract the flow velocity of the liquid drug on the surface of the target drug delivery area and the expansion and contraction characteristics of the oral tissue in the target drug delivery area based on several frames of surface images of the target drug delivery area after spraying. Based on these parameters, it calculates a coughing risk value and reduces the spraying speed if the coughing risk value exceeds a preset risk value. The reduced spraying speed is negatively correlated with the cough risk value.

5. The intraoral liquid drug delivery system according to claim 4, characterized in that, The coughing risk value is the sum of the product of the flow velocity of the liquid drug on the surface of the target drug delivery area and the flow velocity weighting coefficient, and the product of the stretching characteristic parameter of the oral tissue in the target drug delivery area and the stretching characteristic parameter weighting coefficient. The sum of the flow velocity weighting coefficient and the stretching characteristic parameter weighting coefficient is 1.

6. The intraoral liquid drug delivery system according to claim 5, characterized in that, The stretching characteristic parameter is the sum of the product of the stretching speed of the oral tissue in the target drug delivery area and the weighting coefficient of the stretching speed, and the product of the total length of the stretching interruption and the weighting coefficient of the total length of the stretching interruption. The sum of the weighting coefficient of the telescopic speed and the weighting coefficient of the total length of the telescopic interruption is 1.

Images