Pipeline structure for electrospray expiration source

Abstract

The invention provides a pipeline structure for an electrospray expiration source, comprising: a gas path structural member provided with a first end and a second end opposite to each other; a first sheath gas channel and an auxiliary gas channel are formed in the gas path structural member; at the first end, the first sheath gas channel is connected with the sheath gas outlet; the auxiliary gas channel is connected with the auxiliary gas outlet; at the second end, the first sheath gas channel is connected with the first end of the sheath gas tube through a metal connecting piece; the auxiliary gas channel is connected with the first end of the auxiliary gas pipe through a metal connecting piece. The metal connecting piece is used, the sheath air pipe and the auxiliary air pipe are installed on the air path structural piece, the pipeline installation stability can be effectively improved, the situation that the sealing effect of the pipeline is affected by high temperature is avoided, the service life of the auxiliary air pipe and the sheath air pipe is prolonged, and for a high-voltage line connecting structure of an expiration source, limitation of a traditional glue pouring curing technology is broken through; therefore, the problem that the whole module is scrapped due to the fact that the cable cannot be replaced when a fault occurs is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometry equipment, and more particularly to a pipeline structure for an electrospray exhalation source. Background Art

[0002] Extractive Electrospray Ionization-Mass Spectrometry (EESI-MS) is a modern ionization mass spectrometry technique developed from electrospray ionization (ESI) and desorption electrospray ionization (DESI). The EESI source ionizes a high-purity solution without the sample through a single electrospray process, forming tiny charged droplets. These droplets then collide with gas or aerosol particles containing the sample, extracting the components to be analyzed into the charged droplets, thereby forming ions of the analytes for subsequent mass spectrometry detection. This online analytical ion source offers advantages such as direct sample introduction, no sample pretreatment, soft ionization, and the ability to simultaneously analyze gaseous and aerosol phases. It has become a research hotspot in recent years, enabling real-time, online detection of aerosol chemical composition. It is currently widely used to study the composition of exhaled metabolites, the real-time evolution of atmospheric aerosol composition, flavor changes during food processing, explosive composition analysis, and rapid detection of urine, serum, and contaminated water (refs). EESI-MS devices have broad application prospects in health care, environmental monitoring, food safety, drug development, criminal investigation and national security.

[0003] Sheath gas and auxiliary gas play an important role in EESI-MS technology. Sheath gas is used to create a stable aerodynamic environment for electrospray, helping droplets to form smaller particle sizes. Sheath gas can reduce the aggregation between droplets and make the atomized particle size more uniform. Auxiliary gas acts on the spray area of ​​electrospray, increasing the gas flow rate in the atomization area, making the solvent inside the droplets evaporate more quickly. After the solvent in the droplets evaporates, the spray particle size is smaller, and the solvent can be evaporated to the greatest extent before reaching the mass spectrometer, thereby improving the ion yield of mass spectrometry analysis.

[0004] like Figure 1 The figure shows a schematic diagram of the structure of the electrospray exhalation source; wherein, the sheath gas output port of the electrospray exhalation source is led out from the gas path structure and connected to the position of the electrospray bottle through the sheath gas tube, so that the sheath gas is delivered to the nanoliter electrospray bottle to assist in the spraying of the sample.

[0005] In current mass spectrometers, the connection between the sheath gas tube and the gas path structural components is usually connected using sealant. The heat generated by the mass spectrometer will be transferred to the gas path structural components, causing the sealant at the connection to age rapidly, affecting the sealing of the equipment. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the object of the present invention is to provide a pipeline structure for an electrospray exhalation source to overcome the above-mentioned shortcomings.

[0007] The above technical objectives of the present invention are achieved through the following technical solutions: a pipeline structure for an electrospray exhalation source is installed on the electrospray exhalation source, and the electrospray exhalation source includes: a sheath gas outlet and an auxiliary gas outlet; it is characterized in that it includes: an air path structural member, the air path structural member is provided with a first end and a second end opposite to each other; a first sheath gas channel and an auxiliary gas channel are opened inside the air path structural member; at the first end, the first sheath gas channel is connected to the sheath gas outlet; the auxiliary gas channel is connected to the auxiliary gas outlet; at the second end, the first sheath gas channel is connected to the first end of the sheath gas tube through a metal connector; the auxiliary gas channel is connected to the first end of the auxiliary gas tube through a metal connector.

[0008] In one embodiment, at the first end, the distance between the axis of the first sheath gas channel and the axis of the auxiliary gas channel is L1, and at the second end, the distance between the axis of the first sheath gas channel and the axis of the auxiliary gas channel is L2, L1<L2.

[0009] In one embodiment, the auxiliary gas channel includes: a first auxiliary gas sub-channel and a second auxiliary gas sub-channel, the first auxiliary gas sub-channel extends from the first end to the interior of the gas path structure; the second auxiliary gas sub-channel extends from the interior of the gas path structure to the second end; the first auxiliary gas sub-channel and the second auxiliary gas sub-channel are connected inside the gas path structure.

[0010] In one embodiment, the first auxiliary gas sub-channel and the second auxiliary gas sub-channel both extend along a first direction.

[0011] In one embodiment, the auxiliary gas channel further includes: a third auxiliary gas sub-channel; the first auxiliary gas sub-channel is connected to the second auxiliary gas sub-channel through the third auxiliary gas sub-channel, and the third auxiliary gas sub-channel extends along a second direction, and the second direction intersects the first direction.

[0012] In one embodiment, the third auxiliary gas sub-channel extends to the end surface of the gas path structural component, and a first plug is further provided inside the third auxiliary gas sub-channel.

[0013] In one embodiment, the first sheath gas channel extends along the first direction.

[0014] In one embodiment, it also includes: a nanoliter electrospray bottle fixture and a nanoliter electrospray bottle, the nanoliter electrospray bottle fixture is installed on the housing of the electrospray exhalation source; the second end of the sheath air tube is connected to the nanoliter electrospray bottle fixture, and a second sheath air channel is opened inside the nanoliter electrospray bottle fixture, and the sheath air tube is connected to the nanoliter electrospray bottle after passing through the second sheath air channel; the nanoliter electrospray bottle is threadedly connected to the nanoliter electrospray bottle fixture.

[0015] In one embodiment, a sheath gas connector is further included, through which the second end of the sheath gas tube is fixedly connected to the nanoliter electrospray bottle fixing member; the axis of the sheath gas connector is arranged along a third direction, the axis of the second sheath gas channel is arranged along a fourth direction, and the axis of the nanoliter electrospray bottle is arranged along a fifth direction; the third direction, the fourth direction and the fifth direction intersect.

[0016] In one embodiment, the second sheath gas channel extends along the fourth direction to the end surface of the nanoliter electrospray bottle fixing component, and a second plug is further provided in the second sheath gas channel.

[0017] In one embodiment, a high-voltage conductor, a conductive copper rod and a conductive needle are provided inside the nanoliter electric spray bottle fixture; the axis of the conductive needle is arranged along the third direction; the axis of the conductive copper rod is arranged along the fourth direction, and the axis of the high-voltage conductor is arranged along the fifth direction; the high-voltage conductor is electrically connected to the conductive needle after passing through the conductive copper rod.

[0018] In one embodiment, a conductive copper rod mounting hole is provided inside the nanoliter electrospray bottle fixing part; the conductive copper rod is accommodated inside the conductive copper rod mounting hole, and the conductive copper rod mounting hole extends to the end face position of the nanoliter electrospray bottle fixing part; the conductive copper rod mounting hole also accommodates an insulating screw, and the insulating screw presses the conductive needle, the conductive copper rod and the high-voltage conductor against each other.

[0019] In summary, the present invention has the following beneficial effects: for the pipeline structure of the electrospray exhalation source, the present application uses metal connectors to install the sheath air tube and the auxiliary air tube on the air path structural parts, which can effectively improve the stability of the pipeline installation, avoid high temperature affecting the sealing effect of the pipeline, and increase the service life of the auxiliary air tube and the sheath air tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the three-dimensional structure of the electrospray exhalation source of the present invention;

[0021] Figure 2 This is a schematic diagram of the three-dimensional structure of the pipeline structure of the present invention from a first perspective;

[0022] Figure 3 This is a schematic diagram of the three-dimensional structure of the pipeline structure of the present invention from a second perspective;

[0023] Figure 4 This is an exploded schematic diagram of the pipeline structure of the present invention;

[0024] Figure 5 Schematic diagram of the three-dimensional structure of the gas path structural component of the present invention;

[0025] Figure 6 A top view of the gas path structure of the present invention;

[0026] Figure 7 For the present invention Figure 6 Schematic diagram of the cross section at the middle AA position;

[0027] Figure 8 This is a schematic diagram of the three-dimensional structure of the fixing part of the nanoliter electric spray bottle of the present invention;

[0028] Figure 9 This is an exploded schematic diagram of the internal structure of the fixing part of the nanoliter electric spray bottle of the present invention;

[0029] Figure 10 This is an exploded schematic diagram of the internal structure of the nanoliter electric spray bottle fixing part of the present invention from a first perspective;

[0030] Figure 11 For the present invention Figure 10 Schematic diagram of the cross section of the middle BB position;

[0031] Figure 12 This is a schematic diagram of the first perspective of the nanoliter electric spray bottle fixing member of the present invention;

[0032] Figure 13 For the present invention Figure 12 Schematic diagram of the cross section at the middle CC position;

[0033] Figure 14 For the present invention Figure 12 Schematic diagram of the cross section at the middle DD position;

[0034] In the figure: 1. Mass spectrometer housing; 2. Gas path structural component; 201. First end; 202. Second end; 203. First sheath gas channel; 2041. First auxiliary gas channel; 2042. Second auxiliary gas channel; 2043. Third auxiliary gas channel; 205. Metal connector; 206. Sheath gas tube; 207. Auxiliary gas tube; 208. First plug; 3. Nanoliter electrospray bottle fixing part; 301. Sealing ring; 302. High-voltage conductor; 303. Conductive copper rod; 304. Insulating screw; 305. Second plug; 306. Capillary; 307. Sheath gas connector; 308. High-voltage wire; 309. Second sheath gas channel; 310. Tantalum wire; 4. Nanoliter electrospray bottle; 5. Injection module; 6. Ammeter. DETAILED DESCRIPTION

[0035] In the present invention, unless otherwise expressly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be a communication between the two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. The terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of such features.

[0036] In the present invention, unless otherwise expressly specified and limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Moreover, a first feature being "above," "above," and "above" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature includes the first feature being directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature. The terms "vertical," "horizontal," "left," "right," "above," "below," and similar expressions are for illustrative purposes only and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be understood as limiting the present invention.

[0037] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0038] Example 1

[0039] like Figure 1 FIG. 4 is a schematic diagram of the three-dimensional structure of an electrospray breath source. The working process of an electrospray extraction ionization mass spectrometer is as follows: a sample is typically placed in a nanoliter electrospray bottle 4. The sample liquid is slowly guided to the spray end through a capillary 306 and then transported to the mass spectrometer for analysis through an injection module 5. The sample in the nanoliter electrospray bottle 4 is a neutral molecule with no charge and has not yet been ionized. Under a high-voltage electric field of 8 kV, the liquid in the electrospray bottle is sprayed to the outside through the capillary 306. The sample forms a Taylor cone at the tip of the capillary 306, and the liquid is stretched into fine droplets. During the extraction electrospray stage, the sheath gas is typically nitrogen. The sheath gas flows out of the electrospray bottle and forms an airflow around the droplets, accelerating atomization and reducing particle size. In addition, the sheath gas wraps the droplets during the spray process, preventing irregular droplet scattering, helping to focus the spray direction, and preventing diffusion to non-target areas. The auxiliary gas is also typically nitrogen and directly enters the spray path. It contacts the droplet surface along the spray path and quickly removes the solvent. Faster solvent removal enables more dry ions to be transmitted to the mass spectrometer. As the droplet volume decreases, the charge density increases. When the charge exceeds the surface tension of the droplet, the droplet will burst into smaller sub-droplets, ultimately releasing gas-phase ions. Through the synergistic action of the sheath gas and auxiliary gas, the sample droplets are successfully converted into gas-phase ions and introduced into the ionization chamber. The gas-phase ions are sucked into the mass spectrometer through the vacuum interface. In the mass spectrometer, the ions are detected and separated based on the mass-to-charge ratio (m / z) and converted into electrical signals. The computer collects and processes the signals to obtain mass spectrum information.

[0040] like Figure 1As shown, in the existing mass spectrometer, the sheath gas and the auxiliary gas usually need to be drawn out from the gas path structure 2. One end of the gas path structure 2 is connected to the main body of the mass spectrometer. The mass spectrometer is provided with a sheath gas outlet and an auxiliary gas outlet. The sheath gas outlet and the auxiliary gas outlet are arranged side by side in the vertical direction. The other end of the gas path structure 2 is sealed and connected to the sheath gas pipe 206 and the auxiliary gas pipe 207. The distance between the sheath gas outlet and the auxiliary gas outlet on the mass spectrometer is small, usually 6.5 mm. The sheath gas tube 206 can be aligned with the sheath gas outlet, and the auxiliary gas tube 207 can be aligned with the auxiliary gas outlet. The existing mass spectrometer will select a stainless steel tube with an outer diameter of 3.2mm as the sheath gas tube 206 and the auxiliary gas tube 207, and correspondingly open two air holes with an inner diameter of 3.2mm on the gas path structural member 2. The stainless steel tube is inserted into the air hole, and after being connected to the sheath gas outlet and the auxiliary gas outlet on the mass spectrometer respectively, glue is then filled in the gap between the air hole and the stainless steel tube to achieve sealing. This installation method has high processing tolerance requirements for the gas path structural member 2. It is necessary to control the matching tolerance of the outer diameter of the stainless steel tube and the inner diameter of the two air holes of the gas path structural member 2. If the gap is too small, the glue will easily seep out, and if the gap is too large, it will be easy to fix it loosely. In addition, the connection between the gas path structural member 2 and the mass spectrometer body will be affected by the temperature of the mass spectrometer body. The sealant located in the air hole will also be affected by the high temperature and accelerate aging, affecting the sealing effect of the air hole and the stainless steel tube.

[0041] To address the aforementioned issues, the present application improves the air path structural member 2. The air outlet end of the air path structural member 2 is provided with a sheath air hole and an auxiliary air hole, both of which are internally threaded. The first end of the sheath air tube 206 is sealedly connected to the sheath air hole of the air path structural member 2 via a metal connector 205; the first end of the auxiliary air tube 207 is also connected to the auxiliary air hole of the air path structural member 2 via the metal connector 205. The metal connector 205 is made of metal material, and the first ends of the sheath air tube 206 and the auxiliary air tube 207 are mounted to the air path structural member 2 via the metal connector 205, thereby preventing the problem of sealant aging caused by long-term high-temperature operation.

[0042] In order to install a stainless steel tube with an outer diameter of 3.2 mm, the size of the metal connector 205 needs to be at least M5, and the size of the thread inside the sheath hole and the auxiliary hole is also M5; then the distance between the axes of the sheath hole and the auxiliary hole is about 10 mm, that is, the width between the sheath hole and the auxiliary hole is greater than the width between the sheath gas outlet and the auxiliary gas outlet on the mass spectrometer. If a through hole is directly opened on the gas path structure 2 along the axis of the sheath gas outlet and the auxiliary gas outlet, the M5 inner diameter will be connected to each other at the position of the metal connector 2 because the distance between the axes of the two holes is too close.

[0043] In order to solve the above problem, the present application adjusts the vent hole in the gas path structure 2. The end of the gas path structure 2 connected to the gas outlet on the mass spectrometer is recorded as the first end 201, and the end of the gas path structure 2 connected to the stainless steel pipe is recorded as the second end 202. Figure 7 As shown, the gas path structure 2 defines a first sheath gas channel 203. At a first end 201, the first sheath gas channel 203 is connected to the sheath gas outlet. At a second end 202, the first sheath gas channel 203 is connected to the first end of a sheath gas tube 206 via a metal connector 205. The gas path structure 2 also defines an auxiliary gas channel. At a first end 201, the auxiliary gas channel is connected to the auxiliary gas outlet. At a second end 202, the auxiliary gas channel is connected to the first end of an auxiliary gas tube 207 via a metal connector 205.

[0044] At the first end 201, the first sheath gas channel 203 needs to be connected to the sheath gas outlet, and the axis of the first sheath gas channel 203 is aligned with the axis of the sheath gas outlet. The auxiliary gas channel needs to be connected to the auxiliary gas outlet, and the axis of the auxiliary gas channel is aligned with the axis of the auxiliary gas outlet. The distance between the axis of the first sheath gas channel 203 and the axis of the auxiliary gas channel is recorded as L1. At the second end 202, since the first sheath gas channel 203 needs to be connected to the first end of the sheath gas tube 206 through the metal connector 205, the auxiliary gas channel needs to be connected to the first end of the auxiliary gas tube 207 through the metal connector 205. If the distance between the axis of the first sheath gas channel 203 and the axis of the auxiliary gas channel at the second end 202 is recorded as L2, then L1<L2, that is, inside the gas path structure 2, the extension direction of the first sheath gas channel 203 and / or the auxiliary gas channel has changed, so that the distance between the first sheath gas channel 203 and the auxiliary gas channel is increased. After the distance between the first sheath gas channel 203 and the auxiliary gas channel is increased, the metal connector 205 can be sealed and connected to the gas path structure 2 through threads.

[0045] For ease of description, Figure 5 As shown, in this application, the first direction is defined as the shortest connection direction between the first end 201 and the second end 202, that is, the A1A2 direction, and the B1B2 direction is defined as the second direction, and the first direction intersects the second direction.

[0046] In the present application, the first sheath gas channel 203 is processed as a straight through hole, that is, the first sheath gas channel 203 extends in a straight line along the first direction. In order to be able to install the two metal connectors 205 at the second end 202, the auxiliary gas channel cannot be processed in a straight line along the first direction, and needs to be divided into a first auxiliary gas sub-channel 2041 and a second auxiliary gas sub-channel 2042, wherein the axis of the first auxiliary gas sub-channel 2041 is aligned with the axis of the auxiliary gas outlet and extends along the first direction, and the direction of the second auxiliary gas sub-channel 2042 needs to be adjusted according to the distance. When the second auxiliary gas sub-channel 2042 extends to the second end 202 to form an opening, the distance between it and the first sheath gas channel 203 needs to be greater than the space required to install the two metal connectors 205, to avoid conflict due to the small distance between the two channels and the inability to install the metal connectors 205.

[0047] In one case, the direction of the second auxiliary gas sub-channel 2042 also extends in a straight line along the first direction. Because the first auxiliary gas sub-channel 2041 and the second auxiliary gas sub-channel 2042 are parallel to each other and intertwined with each other, it is necessary to open a third auxiliary gas sub-channel 2043. The third auxiliary gas sub-channel 2043 can extend along the second direction, and the second direction intersects with the first direction. Therefore, inside the gas path structure 2, the third auxiliary gas sub-channel 2043 can be connected with the first auxiliary gas sub-channel 2041 and the second auxiliary gas sub-channel 2042, so that the auxiliary gas is transferred from the first end 201 to the second end 202. In order to reduce the processing difficulty, the third auxiliary gas sub-channel 2043 can extend along the second direction to the end face position of the gas path structural component 2. In order to prevent the auxiliary gas from leaking from the third auxiliary gas sub-channel 2043, a first plug 208 is also provided in the third auxiliary gas sub-channel 2043, which can block the extended end of the third auxiliary gas sub-channel 2043, so that the auxiliary gas can only pass through the first auxiliary gas sub-channel 2041, the third auxiliary gas sub-channel 2043 and the second auxiliary gas sub-channel 2042 in turn and then enter the auxiliary gas pipe 207.

[0048] Furthermore, it also includes: a nanoliter electrospray bottle fixing part 3 and a nanoliter electrospray bottle 4. In order to ensure the sealing of the nanoliter electrospray bottle 4, the nanoliter electrospray bottle fixing part 3 is made of metal material. The second end of the sheath gas tube 206 is fixed to the nanoliter electrospray bottle fixing part 3 through an M5 specification sheath gas connector 307. Figure 14 As shown, because there is a certain distance between the sheath gas connector 307 and the nanoliter electrospray bottle 4 in the horizontal direction, it is necessary to open a connecting hole inside the nanoliter electrospray bottle fixing part 3 so that the sheath gas can smoothly enter the nanoliter electrospray bottle 4. Figure 9As shown, the axial direction of the sheath gas connector 307 is limited to the third direction (that is, the D1D2 direction in the figure), the axial direction of the second sheath gas channel 309 is limited to the fourth direction (that is, the E1E2 direction in the figure), and the axial direction of the nanoliter electrospray bottle 4 is limited to the fifth direction (that is, the F1F2 direction in the figure), and the third direction, the fourth direction and the fifth direction intersect.

[0049] In order to reduce the processing difficulty, in the actual processing process, the nanoliter electrospray bottle fixing part 3 is processed from a whole piece of metal material. In order to reduce the processing difficulty, the second sheath gas channel 309 extending along the fourth direction can be extended to the end face position of the nanoliter electrospray bottle fixing part 3. That is, using the hole opening technology, a hole is directly drilled on the nanoliter electrospray bottle fixing part 3 along the fourth direction. The drilling can connect the space where the nanoliter electrospray bottle 4 is located and the space where the sheath gas tube 206 connector is located to each other. The drilling will also cause the second sheath gas channel 309 to be open at the end face position. In order to prevent the sheath gas from leaking from the hole, it is necessary to add a second plug 305 at the end of the second sheath gas channel 309 so that the sheath gas can only enter the electrospray bottle through the second sheath gas channel 309.

[0050] Furthermore, the nanoliter electrospray bottle holder 3 is equipped with a high-voltage assembly. The high-voltage output terminal of the mass spectrometer is connected to the high-voltage assembly via a high-voltage wire 308. The high-voltage assembly includes a conductive copper rod 303 and a high-voltage conductor 302. The high-voltage conductor 302 surrounds the exterior of the capillary 306, with its axis arranged along the fifth direction and coaxial with the nanoliter electrospray bottle 4. This provides a high-voltage electric field to the capillary 306, causing the sample in the capillary 306 to form a Taylor cone. The high-voltage wire 308, which is led from the ammeter 6, is stripped of its outer insulation layer, inserted into a conductive needle, and secured with solder. The conductive needle is inserted into the nanoliter electrospray bottle holder 3 along the third direction. To electrically connect the conductive needle and the high-voltage conductor 302, a conductive copper rod 303 installed along the fourth direction is required to connect the conductive needle and the high-voltage conductor 302. In order to facilitate the installation of the conductive copper rod 303, it is necessary to open a conductive copper rod mounting hole along the fourth direction on the nanoliter electrospray bottle fixture 3 and extend it to the position of the high-voltage conductor 302. After the conductive copper rod 303 is installed inside the conductive copper rod mounting hole, it is necessary to use an insulating fixing screw to seal the conductive copper rod mounting hole. The insulating screw 304 also presses the conductive needle and the conductive copper rod 303 against each other to achieve a stable conductive connection and prevent the conductive needle and the conductive copper rod 303 from being separated and unable to be energized. In this embodiment, the insulating fixing screw is made of PEEK material. In this application, the high-voltage wire 308 is welded to the conductive needle and the insulating screw is used to fix the conductive needle to the nanoliter electrospray bottle fixture 3, breaking through the limitations of the traditional glue filling and curing process, developing a detachable high-voltage cable interface, avoiding the problem of the entire nanoliter electrospray bottle fixture 3 being scrapped due to the non-replaceable cable in the event of a fault. The high-voltage wire connection structure in this application abandons the high-cost industrial plug assembly and innovatively adopts a PEEK material sleeve type crimping assembly, which greatly reduces manufacturing costs and improves assembly efficiency while ensuring stable electrical performance.

[0051] Furthermore, the nanoliter electrospray bottle fixing part 3 is fixed to the mass spectrometer housing 1 by screws; the capillary 306 on the nanoliter electrospray bottle fixing part 3 extends from the nanoliter electrospray bottle 4 to the sampling module 5, and the sampling module 5 is used to transport the sample of the capillary 306 into the ionization chamber; the capillary 306 is fixed by the capillary fixing component and sealed on the nanoliter electrospray bottle fixing part 3 by the sealing ring 301; the high-voltage conductor 302 has a sealing ring 301 on the upper and lower sides and is fixed in the small chamber specified by the main body of the nanoliter electrospray bottle fixing part 3; one end of the tantalum wire 310 is wrapped around the high-voltage conductor 302 and leaves a space of about 2 mm at the mouth of the nanoliter electrospray bottle 4; the other end of the tantalum wire 310 extends downward to the interior of the nanoliter electrospray bottle 4; the high-voltage wire 308 is in contact with the conductive copper rod 303 and is insulated The insulating screw 304 presses the high-voltage wire 308 onto the conductive copper rod 303, and finally the insulating screw 304 is tightened to the main body of the nanoliter electrospray bottle fixture 3. In this way, the high-voltage wire 308 is tightly fixed, thereby opening the high-voltage path of the exhalation source nanoliter electrospray bottle fixture 3 module: the 8KV high-voltage electrical signal from the mass spectrometer first passes through one end of the nanoampere ammeter 6, and then comes out from the other end to be conducted to the conductive copper rod 303, then conducts with the high-voltage conductor 302, and finally conducts with the solution in the electrospray bottle through the tantalum wire 310; the nanoliter electrospray bottle 4 is threadedly connected to the nanoliter electrospray bottle fixture 3 through the fixing adapter and the sealing ring 301; when the nanoliter electrospray bottle 4 needs to be cleaned or the solution in the nanoliter electrospray bottle 4 needs to be replaced, it can be unscrewed by gently twisting it downwards. In this application, the complex structure of the traditional nanoliter electrospray bottle 4 requiring a double-action sealing ring is optimized into a single metal quick-plug interface, and the multi-stage leakage risk is eliminated through an integrated sealing solution, significantly improving the reliability of the gas path.

[0052] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0053] The above are merely preferred embodiments of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions based on the principles of the present invention are within the scope of protection of the present invention. It should be noted that improvements and modifications that do not depart from the principles of the present invention are within the scope of protection of the present invention.

Claims

1. A piping structure for an electrospray exhalation source, mounted on the electrospray exhalation source, the electrospray exhalation source comprising: Sheath gas outlet and auxiliary gas outlet; It is characterized by comprising: an air path structural member, wherein the air path structural member is provided with a first end and a second end opposite to each other; A first sheath gas channel and an auxiliary gas channel are provided inside the gas path structural component; At the first end, the first sheath gas channel is connected to the sheath gas outlet; the auxiliary gas channel is connected to the auxiliary gas outlet; At the second end, the first sheath gas channel is connected to the first end of the sheath gas tube through a metal connector; the auxiliary gas channel is connected to the first end of the auxiliary gas tube through a metal connector.

2. The pipeline structure for the electrospray exhalation source according to claim 1, characterized in that: At the first end, the distance between the axis of the first sheath gas channel and the axis of the auxiliary gas channel is L1. At the second end, the distance between the axis of the first sheath gas channel and the axis of the auxiliary gas channel is L2, and L1<L2.

3. The pipeline structure for the electrospray exhalation source according to claim 1, characterized in that: The auxiliary gas channel includes: a first auxiliary gas channel and a second auxiliary gas channel, the first auxiliary gas channel extends from the first end to the interior of the gas path structure; the second auxiliary gas channel extends from the interior of the gas path structure to the second end; the first auxiliary gas channel and the second auxiliary gas channel are connected to the interior of the gas path structure.

4. The pipeline structure for the electrospray exhalation source according to claim 3, characterized in that: The first sheath gas channel, the first auxiliary gas sub-channel, and the second auxiliary gas sub-channel all extend along a first direction.

5. The pipeline structure for the electrospray exhalation source according to claim 4, characterized in that: The auxiliary gas channel further includes: a third auxiliary gas sub-channel; the first auxiliary gas sub-channel is connected to the second auxiliary gas sub-channel through the third auxiliary gas sub-channel, and the third auxiliary gas sub-channel extends along a second direction, and the second direction intersects the first direction.

6. The pipeline structure for the electrospray exhalation source according to claim 5, characterized in that: The third auxiliary gas sub-channel extends to the end surface of the gas path structural component, and a first plug is further provided inside the third auxiliary gas sub-channel.

7. The pipeline structure for the electrospray exhalation source according to claim 1, characterized in that: Also includes: A nanoliter electrospray bottle fixture and a nanoliter electrospray bottle, wherein the nanoliter electrospray bottle fixture is mounted on the housing of the electrospray exhalation source; the second end of the sheath air tube is connected to the nanoliter electrospray bottle fixture, a second sheath air channel is provided inside the nanoliter electrospray bottle fixture, and the sheath air tube is connected to the nanoliter electrospray bottle after passing through the second sheath air channel; the nanoliter electrospray bottle is threadedly connected to the nanoliter electrospray bottle fixture.

8. The pipeline structure for the electrospray exhalation source according to claim 7, characterized in that: It also includes a sheath gas connector, through which the second end of the sheath gas tube is fixedly connected to the nanoliter electrospray bottle fixing member; The axis of the sheath gas connector is arranged along the third direction, the axis of the second sheath gas channel is arranged along the fourth direction, and the axis of the nanoliter electrospray bottle is arranged along the fifth direction; the second sheath gas channel extends along the fourth direction to the end surface position of the nanoliter electrospray bottle fixing member, and a second plug is further provided in the second sheath gas channel; The third direction, the fourth direction, and the fifth direction intersect.

9. The pipeline structure for the electrospray exhalation source according to claim 8, characterized in that: The interior of the nanoliter electric spray bottle fixing member is provided with a high-voltage conductor, a conductive copper rod and a conductive needle; The axis of the conductive needle is arranged along the third direction; the axis of the conductive copper rod is arranged along the fourth direction; and the axis of the high-voltage conductor is arranged along the fifth direction; The high-voltage conductor is electrically connected to the conductive needle after passing through the conductive copper rod.

10. The pipeline structure for the electrospray exhalation source according to claim 9, characterized in that: A conductive copper rod mounting hole is provided inside the nanoliter electrospray bottle fixing piece; The conductive copper rod is accommodated in the conductive copper rod mounting hole, and the conductive copper rod mounting hole extends to the end surface position of the nanoliter electrospray bottle fixing part; An insulating screw is also housed inside the conductive copper rod mounting hole, and the insulating screw presses the conductive needle, the conductive copper rod and the high-voltage conductor against each other.

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