Alcohol disinfectant safe to skin and preparation method thereof

Abstract

The invention relates to the technical field of alcohol disinfectants, in particular to an alcohol disinfectant safe to skin and a preparation method of the alcohol disinfectant safe to skin. Adding a surfactant into the first-stage basic solution, and uniformly mixing to obtain a second-stage mixed solution; adding a pH regulator into the second-stage mixed solution, and regulating the pH value to a range suitable for the skin to obtain a third-stage regulated solution; auxiliary components and a humectant are added into the third-stage adjustment solution, and a fourth-stage optimization solution is obtained; a synergist is added into the fourth-stage optimized solution, and the alcohol disinfectant is obtained; therefore, the alcohol disinfectant is modulated into a range suitable for the skin through the pH regulator, the storage time and fragrance of the alcohol disinfectant can be improved by the aid of the auxiliary components, pungent conditions are reduced, the alcohol disinfectant can have a certain moisturizing effect by the aid of the moisturizer, dryness of the skin of a patient due to alcohol volatilization is avoided, and the skin care effect of the patient is improved. The use experience of the patient is obviously improved.

Description

Technical Field

[0001] The present invention relates to the technical field of alcohol disinfectants, and in particular to an alcohol disinfectant that is safe for the skin and a preparation method thereof. Background Art

[0002] Alcohol disinfectant is commonly used for disinfection and sterilization. Alcohol disinfectant is a liquid disinfectant with ethanol as the main active ingredient. It achieves the purpose of sterilization by denaturing proteins. It can be sprayed on door handles or tabletops to disinfect the home environment. It can also be used in medical places, such as to disinfect surgical instruments or the hands of medical staff.

[0003] In the aforementioned prior art, although traditional alcohol disinfectants have strong bactericidal and disinfecting capabilities, they usually have a pungent and unpleasant smell and are not mild enough. They can easily irritate the patient's skin after contact with the skin, or cause dryness of the patient's skin after evaporation, thus greatly affecting the patient's usage experience. Summary of the Invention

[0004] The purpose of the present invention is to provide a skin-safe alcohol disinfectant and a preparation method thereof, so as to solve the problem that traditional alcohol disinfectants in the prior art, although having strong bactericidal and disinfecting capabilities, usually have a pungent and unpleasant smell and are not mild enough. They are easy to irritate the patient's skin after contact with the skin, or cause the patient's skin to dry out after evaporation, thus greatly affecting the patient's usage experience.

[0005] To achieve the above objectives, the present invention provides a method for preparing a skin-safe alcohol disinfectant, comprising the following steps:

[0006] Mix the alcohol with water to form a primary base solution;

[0007] adding a surfactant to the primary base solution and mixing them uniformly to obtain a secondary mixed solution;

[0008] Adding a pH regulator to the secondary mixed solution to adjust the pH value to a range suitable for the skin to obtain a tertiary adjusted solution;

[0009] adding auxiliary ingredients and moisturizing agents to the third-level adjustment solution to obtain a fourth-level optimized solution;

[0010] A synergist is added to the four-stage optimized solution to obtain an alcohol disinfectant.

[0011] Wherein, alcohol is mixed with water to form a primary basic solution, specifically comprising:

[0012] Introduce ethanol circulating liquid into the interlayer of the double-layer glass reactor as an ice bath medium and pre-cool to -5℃±0.5℃;

[0013] Fill the reactor with deionized water to the mark, and then slowly add denatured ethanol using the bottom-inlet method;

[0014] Start the anchor agitator at 50 rpm, increase by 5 rpm every 5 minutes to a final speed of 100 rpm, and continue for 15 minutes;

[0015] Thermocouple probes are arranged at three points in the reactor, and the data are averaged and fed back to the PID control system.

[0016] Wherein, a surfactant is added to the primary base solution and mixed evenly to obtain a secondary mixed solution, which specifically includes:

[0017] Use a vacuum homogenizer and maintain the vacuum degree at -0.8 bar;

[0018] The reactor temperature was raised in a trapezoidal pattern from 25°C to 40°C, with a constant temperature of 5°C for 5 minutes.

[0019] Add 30% of the total amount of surfactant, stir at 400 r / min, and maintain for ten minutes;

[0020] Add the remaining 70% surfactant and use a stator homogenizer to stir at 8000 rpm for 5 minutes;

[0021] Finally, ultrasonic coupling treatment was turned on for 5 minutes.

[0022] Wherein, a pH regulator is added to the secondary mixed solution to adjust the pH value to a range suitable for the skin to obtain a tertiary adjustment solution, specifically comprising:

[0023] Citric acid and disodium hydrogen phosphate were dissolved as buffer at a molar ratio of 1:1.4 and pre-adjusted to pH 5.3;

[0024] The buffer solution was added in 5 equal portions at intervals. After each addition, vortex stirring was started for 2 minutes at a speed of 200 r / min.

[0025] 0.1 mol / L sodium hydroxide solution was used as a pH adjuster and added to the reactor in 10 pulses via an automatic titrator;

[0026] Keep stirring for 30 minutes and then re-measure the pH to ensure that the pH is ≤ 0.1.

[0027] Wherein, auxiliary components and moisturizing agents are added to the three-stage adjustment solution to obtain a four-stage optimized solution, which specifically includes:

[0028] The three-stage adjustment solution was cooled to 30°C ± 0.5°C at a rate of 5°C / min through a spiral tube heat exchanger;

[0029] Glycerol was added continuously via a peristaltic pump;

[0030] Prepare a 0.5% solution in deionized water in advance and add sodium hyaluronate through a microporous filter membrane;

[0031] Antioxidants were added by injection under nitrogen protection;

[0032] After dissolving the stabilizer in deionized water, add it into the reactor via a micro-injection pump;

[0033] Finally, add spices into the reactor and stir at 200r / min for 5 minutes.

[0034] Wherein, a synergist is added to the four-stage optimized solution to obtain an alcohol disinfectant, specifically comprising:

[0035] injecting a synergist into the reactor through a microchannel reactor;

[0036] The solution in the reactor was homogenized at 100 MPa to destroy the synergist agglomerates and reduce the particle size from 5-10 μm to 500 nm;

[0037] Perform secondary homogenization at 150 MPA to refine the particle size to D90 < 100 nm;

[0038] Set up a heat exchanger to cool the reactor and ensure that the temperature of the fourth-level optimized solution is ≤35℃.

[0039] The present invention also provides a skin-safe alcohol disinfectant, which adopts the above-mentioned skin-safe alcohol disinfectant preparation method and comprises 62%-78% alcohol, 14.5%-26.5% water, 0.5%-1.5% surfactant, 1.3%-1.9% pH regulator, 0.4%-0.8% auxiliary components, 2%-5% moisturizer, and 2.3%-3.3% synergist.

[0040] The pH regulator includes a buffer solution and a 0.1 mol / L sodium hydroxide solution in a ratio of 95:5.

[0041] The auxiliary ingredients include antioxidants, stabilizers and spices in a ratio of 5:2:3.

[0042] Wherein, the moisturizing agent includes glycerin and sodium hyaluronate in a ratio of 4:1.

[0043] The present invention discloses a skin-safe alcohol disinfectant and a preparation method thereof. The method comprises the following steps: mixing alcohol and water to form a primary base solution; adding a surfactant to the primary base solution and mixing them uniformly to obtain a secondary mixed solution; adding a pH adjuster to the secondary mixed solution to adjust the pH value to a range suitable for skin to obtain a tertiary adjusted solution; adding auxiliary components and a moisturizer to the tertiary adjusted solution to obtain a quaternary optimized solution; and adding a synergist to the quaternary optimized solution to obtain an alcohol disinfectant. The pH adjuster is used to adjust the alcohol disinfectant to a range suitable for skin, thereby reducing skin irritation. The auxiliary components can also increase the storage life and fragrance of the alcohol disinfectant, thereby reducing irritation. The moisturizer can also ensure that the alcohol disinfectant has a certain moisturizing effect, thereby preventing alcohol volatilization from drying the patient's skin. The synergist is tea tree oil, which, in combination with the moisturizer, leaves a thin protective film on the skin even after the alcohol disinfectant evaporates, providing continuous antibacterial protection. This significantly improves the user experience of the patient. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art.

[0045] Figure 1 is a flowchart of the steps of the first embodiment of the present invention.

[0046] Figure 2 is a flowchart of the steps of the second embodiment of the present invention.

[0047] Figure 3 is a flowchart of the steps of the third embodiment of the present invention. DETAILED DESCRIPTION

[0048] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0049] The present invention provides a method for preparing an alcohol disinfectant that is safe for skin, comprising the following steps:

[0050] Mix the alcohol with water to form a primary base solution;

[0051] Specifically include:

[0052] Introduce ethanol circulating liquid into the interlayer of the double-layer glass reactor as an ice bath medium and pre-cool to -5℃±0.5℃;

[0053] Due to the low freezing point of ethanol (about 114°C lower than water), it can still maintain liquid flow at -5°C, forming a uniform low-temperature environment. This prevents the generation of steam due to local overheating when denatured ethanol is added (ethanol boiling point 78.3°C), inhibits the oxidative decomposition of temperature-sensitive ingredients (such as some plant extracts), and improves the thermodynamic efficiency of the subsequent mixing process (low temperature reduces liquid viscosity).

[0054] Fill the reactor with deionized water to the mark, and then slowly add denatured ethanol using the bottom-inlet method;

[0055] The static pressure difference of the fluid is used to achieve laminar injection, avoid turbulent bubbles, reduce local over-concentration when mixing ethanol and water, and improve mixing uniformity (compared to top injection, the mixing efficiency is improved).

[0056] Start the anchor agitator at 50 rpm, increase by 5 rpm every 5 minutes to a final speed of 100 rpm, and continue for 15 minutes;

[0057] Micro-mixing was achieved by shear rate gradient control: an initial low speed (50 rpm) prevented ethanol impact and foaming; a step-by-step increase in speed (5 rpm / 5 min) gradually enhanced turbulent diffusion; and a final speed of 100 rpm ensured a Reynolds number Re>1000 (fully turbulent state), resulting in a mixing uniformity CV value of <2%.

[0058] Thermocouple probes are arranged at three points in the reactor, and the data are averaged and fed back to the PID control system.

[0059] A three-dimensional temperature field monitoring network is constructed by arranging thermocouple probes at three points, so that the standard deviation of temperature field uniformity is less than 0.3°C, effectively preventing component inactivation caused by local overheating.

[0060] adding a surfactant to the primary base solution and mixing them uniformly to obtain a secondary mixed solution;

[0061] Specifically include:

[0062] Use a vacuum homogenizer and maintain the vacuum degree at -0.8 bar;

[0063] By reducing the pressure to below the water vapor partial pressure, the dissolved oxygen efficiency is removed to >95% (to prevent oxidation reaction); volatile impurities are removed, and the residual bubble diameter is <0.05mm, thereby improving the homogenization effect.

[0064] The reactor temperature was raised in a trapezoidal pattern from 25°C to 40°C, with a constant temperature of 5°C for 5 minutes.

[0065] By controlling the molecular movement rate through the temperature gradient, the system viscosity decreases by about 12% for every 5°C temperature increase. At the same time, the difference in solubility parameters between the surfactant and ethanol is reduced by 0.5-1.2. Compared with direct temperature increase, the mixing energy consumption is reduced by about 30%.

[0066] Add 30% of the total amount of surfactant, stir at 400 r / min, and maintain for ten minutes;

[0067] Add the remaining 70% surfactant and use a stator homogenizer to stir at 8000 rpm for 5 minutes;

[0068] Through the first stage (30%): the primary micelle structure is formed with a particle size D50≈50nm, and then the second stage (70%): the micelles are reorganized into a lamellar liquid crystal structure, and the stability is improved by 40%, thereby achieving dispersion uniformity: the final micelle particle size distribution span is <2 (PDI<0.3).

[0069] At the same time, the microstructure is controlled by the shear force gradient. In the low-speed stage (400 rpm), vortex mixing is formed, and the macroscopic uniformity is >95%; in the high-speed stage (8000 rpm), turbulent micro-vortices are generated.

[0070] Finally, ultrasonic coupling treatment was turned on for 5 minutes.

[0071] It can generate an instantaneous pressure of >500MPa and a high temperature of 5000K, causing the cavitation bubbles to collapse; at the same time, the hydrophilic-lipophilic balance (HLB) value of the surfactant is adjusted by ±0.5 to modify the interface; and ultrasonic treatment for 5 minutes is equivalent to the sterilization effect of 20kJ / L ultraviolet radiation.

[0072] Adding a pH regulator to the secondary mixed solution to adjust the pH value to a range suitable for the skin to obtain a tertiary adjusted solution;

[0073] Specifically include:

[0074] Citric acid and disodium hydrogen phosphate were dissolved as buffer at a molar ratio of 1:1.4 and pre-adjusted to pH 5.3;

[0075] In the disinfectant system, the buffer solution can produce a chemical buffering effect to maintain the pH value of the system stable in the skin-friendly range (pH5.5±0.3)

[0076] The buffer solution was added in 5 equal portions at intervals. After each addition, vortex stirring was started for 2 minutes at a speed of 200 r / min.

[0077] By adding in batches, a gradient buffering effect can be achieved, and it also helps to improve the uniformity of stirring and mixing.

[0078] 0.1 mol / L sodium hydroxide solution was used as a pH adjuster and added to the reactor in 10 pulses via an automatic titrator;

[0079] The automatic titrator can accurately control the volume of sodium hydroxide solution added, so that the pH control error is <0.05, which improves the accuracy compared to manual addition. At the same time, the pulse volume is <0.5mL each time, avoiding component hydrolysis caused by local pH>8.5.

[0080] Keep stirring for 30 minutes and then re-measure the pH to ensure that the pH is ≤ 0.1.

[0081] After retesting, the durability of the buffer system can be verified, and subsequent operations can be continued if it meets the standards.

[0082] adding auxiliary ingredients and moisturizing agents to the third-level adjustment solution to obtain a fourth-level optimized solution;

[0083] Specifically include:

[0084] The three-stage adjustment solution was cooled to 30°C ± 0.5°C at a rate of 5°C / min through a spiral tube heat exchanger;

[0085] A cooling rate of <10°C / min can prevent the formation of ice crystals in the ethanol-water system. At the same time, the kinematic viscosity of the solution inside the reactor at 30°C is ν = 1.2 cP (18% lower than at 25°C), which improves the subsequent mixing efficiency.

[0086] Glycerol was added continuously via a peristaltic pump;

[0087] The peristaltic pump can be used to control the addition accuracy and improve the dispersion uniformity. The added glycerin can play a moisturizing role.

[0088] Prepare a 0.5% solution in deionized water in advance and add sodium hyaluronate through a microporous filter membrane;

[0089] The pores of the microporous filter membrane are 0.45μm, which can intercept microorganisms and maintain the clarity of the solution. At the same time, the added sodium hyaluronate can also play a moisturizing role, and combined with glycerin, it can prevent the evaporation of alcohol from causing dryness and damage to the patient's skin.

[0090] Antioxidants were added by injection under nitrogen protection;

[0091] By using nitrogen to create an oxygen-free operating environment, antioxidants can function more effectively under the protection of nitrogen, delaying the oxidation and deterioration of substances and extending the shelf life.

[0092] After dissolving the stabilizer in deionized water, add it into the reactor via a micro-injection pump;

[0093] After dissolving the stabilizer, it is added by means of a microinjection pump, thereby improving the accuracy of addition and avoiding large errors; at the same time, the stabilizer can maintain the chemical stability, physical properties and disinfection efficacy of alcohol, and avoid component decomposition, volatilization, stratification or phase change during storage or use.

[0094] Finally, add spices into the reactor and stir at 200r / min for 5 minutes.

[0095] Add spices and stir evenly to increase the aroma of the alcohol disinfectant, avoid pungent smell, and improve the patient experience.

[0096] A synergist is added to the four-stage optimized solution to obtain an alcohol disinfectant.

[0097] Specifically include:

[0098] injecting a synergist into the reactor through a microchannel reactor;

[0099] Microchannel reactors feature tiny channels (typically on the micron to millimeter scale) that allow reactants to mix and react rapidly. During the injection of the synergist into the reactor, the microchannel reactor precisely controls the flow rate, velocity, and concentration of the synergist. For some concentration-sensitive synergists, the microchannel reactor enables precise control at microliter or even nanoliter scales, ensuring the synergist mixes with raw materials like alcohol in the appropriate proportions, thereby improving the performance of the alcohol disinfectant. Furthermore, the microchannel reactor's large surface area significantly increases the contact area between reactants, accelerating the reaction rate. During the production of the alcohol disinfectant, the synergist reacts rapidly with raw materials like alcohol within the microchannels, shortening the reaction time. Furthermore, the synergist, hydrogen peroxide, produces a synergistic bactericidal effect with alcohol. The synergist disrupts bacterial cell membranes, allowing alcohol to more easily penetrate the cells, thereby enhancing the alcohol's ability to kill bacteria. The synergist also inhibits bacterial repair mechanisms, preventing bacteria from self-repairing after alcohol attack, further enhancing the bactericidal effect.

[0100] The solution in the reactor was homogenized at 100 MPa to destroy the synergist agglomerates and reduce the particle size from 5-10 μm to 500 nm;

[0101] Perform secondary homogenization at 150 MPA to refine the particle size to D90 < 100 nm;

[0102] Through primary and secondary homogenization, the solubility of the synergist can be enhanced, so that it can be integrated with the solution in the reactor more quickly, and the activity of the synergist can also be improved. In addition, larger synergist particles are prone to sedimentation and aggregation in the solution, resulting in unstable performance of the disinfectant. Therefore, homogenization can improve the stability of the solution.

[0103] Set up a heat exchanger to cool the reactor and ensure that the temperature of the fourth-level optimized solution is ≤35℃.

[0104] By controlling the temperature, chemical stability is ensured, alcohol volatilization is avoided, and the quality of the solution is guaranteed.

[0105] For example 1, please refer to Figure 1 The present invention also provides a skin-safe alcohol disinfectant, comprising the following steps:

[0106] S1: Mix 62% alcohol with 26.5% water to form a primary base solution;

[0107] S2: adding 0.5% surfactant to the primary base solution and mixing uniformly to obtain a secondary mixed solution;

[0108] S3: adding 1.9% buffer solution and 0.1 mol / L sodium hydroxide solution to the secondary mixed solution, adjusting the pH value to a range suitable for the skin, to obtain a tertiary adjustment solution;

[0109] S4: adding 0.8% of antioxidant, stabilizer and fragrance and 5% of glycerin and sodium hyaluronate to the third-level adjustment solution to obtain a fourth-level optimized solution;

[0110] S5: adding 3.3% of a synergist to the fourth-level optimized solution to obtain an alcohol disinfectant.

[0111] For example 2, please refer to Figure 2 The present invention also provides a skin-safe alcohol disinfectant, comprising the following steps:

[0112] S1: Mix 78% alcohol with 14.5% water to form a primary base solution;

[0113] S2: adding 1.5% of a surfactant to the primary base solution and mixing uniformly to obtain a secondary mixed solution;

[0114] S3: adding 1.3% buffer and 0.1 mol / L sodium hydroxide solution to the secondary mixed solution, adjusting the pH value to a range suitable for the skin, to obtain a tertiary adjustment solution;

[0115] S4: adding 0.4% of antioxidant, stabilizer and fragrance and 2% of glycerin and sodium hyaluronate to the third-level adjustment solution to obtain a fourth-level optimized solution;

[0116] S5: adding 2.3% of a synergist to the fourth-level optimized solution to obtain an alcohol disinfectant.

[0117] For example three, please refer to Figure 3The present invention also provides a skin-safe alcohol disinfectant, comprising the following steps:

[0118] S1: Mix 70% alcohol with 21.5% water to form a primary base solution;

[0119] S2: adding 1% surfactant to the primary base solution and mixing uniformly to obtain a secondary mixed solution;

[0120] S3: adding 1.6% buffer solution and 0.1 mol / L sodium hydroxide solution to the secondary mixed solution, adjusting the pH value to a range suitable for the skin, to obtain a tertiary adjustment solution;

[0121] S4: adding 0.5% of antioxidant, stabilizer and fragrance and 3% of glycerin and sodium hyaluronate to the third-level adjustment solution to obtain a fourth-level optimized solution;

[0122] S5: adding 2.4% synergist to the fourth-level optimized solution to obtain an alcohol disinfectant.

[0123] The above disclosure is merely one or more preferred embodiments of the present application and is not intended to limit the scope of the present application. A person skilled in the art will understand that all or part of the processes of the above embodiments and equivalent changes made in accordance with the claims of the present application are still within the scope of the present application.

Claims

1. A method for preparing an alcohol disinfectant that is safe for the skin, characterized in that: The steps include: Mix the alcohol with water to form a primary base solution; adding a surfactant to the primary base solution and mixing them uniformly to obtain a secondary mixed solution; Adding a pH regulator to the secondary mixed solution to adjust the pH value to a range suitable for the skin to obtain a tertiary adjusted solution; adding auxiliary ingredients and moisturizing agents to the third-level adjustment solution to obtain a fourth-level optimized solution; A synergist is added to the four-stage optimized solution to obtain an alcohol disinfectant.

2. The method for preparing a skin-safe alcohol disinfectant according to claim 1, wherein: Mix the alcohol with water to create a primary base solution consisting of: Introduce ethanol circulating liquid into the interlayer of the double-layer glass reactor as an ice bath medium and pre-cool to -5℃±0.5℃; Fill the reactor with deionized water to the mark, and then slowly add denatured ethanol using the bottom-inlet method; Start the anchor agitator at 50 rpm, increase by 5 rpm every 5 minutes to a final speed of 100 rpm, and continue for 15 minutes; Thermocouple probes are arranged at three points in the reactor, and the data are averaged and fed back to the PID control system.

3. The method for preparing a skin-safe alcohol disinfectant according to claim 2, wherein: Adding a surfactant to the primary base solution and mixing them evenly to obtain a secondary mixed solution, specifically comprising: Use a vacuum homogenizer and maintain the vacuum degree at -0.8 bar; The reactor temperature was raised in a trapezoidal pattern from 25°C to 40°C, with a constant temperature of 5°C for 5 minutes. Add 30% of the total amount of surfactant, stir at 400 r / min, and maintain for ten minutes; Add the remaining 70% surfactant and use a stator homogenizer to stir at 8000 rpm for 5 minutes; Finally, ultrasonic coupling treatment was turned on for 5 minutes.

4. The method for preparing a skin-safe alcohol disinfectant according to claim 3, wherein: Adding a pH regulator to the secondary mixed solution to adjust the pH value to a range suitable for the skin to obtain a tertiary adjustment solution, specifically comprising: Citric acid and disodium hydrogen phosphate were dissolved as buffer at a molar ratio of 1:1.4 and pre-adjusted to pH 5.3; The buffer solution was added in 5 equal portions at intervals. After each addition, vortex stirring was started for 2 minutes at a speed of 200 r / min. 0.1 mol / L sodium hydroxide solution was used as a pH adjuster and added to the reactor in 10 pulses via an automatic titrator; Keep stirring for 30 minutes and then re-measure the pH to ensure that the pH is ≤ 0.

1.

5. The method for preparing a skin-safe alcohol disinfectant according to claim 4, wherein: Auxiliary ingredients and moisturizers are added to the three-stage adjustment solution to obtain a four-stage optimized solution, which specifically includes: The three-stage adjustment solution was cooled to 30°C ± 0.5°C at a rate of 5°C / min through a spiral tube heat exchanger; Glycerol was added continuously via a peristaltic pump; Prepare a 0.5% solution in deionized water in advance and add sodium hyaluronate through a microporous filter membrane; Antioxidants were added by injection under nitrogen protection; After dissolving the stabilizer in deionized water, add it into the reactor via a micro-injection pump; Finally, add spices into the reactor and stir at 200r / min for 5 minutes.

6. The method for preparing a skin-safe alcohol disinfectant according to claim 5, wherein: Adding a synergist to the four-stage optimized solution to obtain an alcohol disinfectant specifically comprises: injecting a synergist into the reactor through a microchannel reactor; The solution in the reactor was homogenized at 100 MPa to destroy the synergist agglomerates and reduce the particle size from 5-10 μm to 500 nm; Perform secondary homogenization at 150 MPA to refine the particle size to D90 < 100 nm; Set up a heat exchanger to cool the reactor and ensure that the temperature of the fourth-level optimized solution is ≤35℃.

7. A skin-safe alcohol disinfectant, comprising the method for preparing the skin-safe alcohol disinfectant according to claim 6, characterized in that: Calculated by percentage, the raw materials for its preparation include: 62%-78% alcohol, 14.5%-26.5% water, 0.5%-1.5% surfactant, 1.3%-1.9% pH adjuster, 0.4%-0.8% auxiliary ingredients, 2%-5% moisturizer, 2.3%-3.3% synergist.

8. The skin-safe alcohol disinfectant according to claim 7, characterized in that: The pH regulator includes a buffer solution and a 0.1 mol / L sodium hydroxide solution in a ratio of 95:

5.

9. The skin-safe alcohol disinfectant according to claim 8, characterized in that: The auxiliary ingredients include antioxidants, stabilizers and spices in a ratio of 5:2:

3.

10. The skin-safe alcohol disinfectant according to claim 9, characterized in that: The moisturizing agent includes glycerin and sodium hyaluronate in a ratio of 4:1.

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