Tumor electric field treatment device and electrode patch thereof

Abstract

The invention provides a tumor electric field treatment device and an electrode patch thereof, the electrode patch comprises an electrode array, and the electrode array comprises thirteen electrode units with dielectric elements. The four electrode units located at the corners, the two electrode units located in the center area and the two electrode units located at the non-corners of the edges are each provided with a temperature sensor. The electrode array comprises a flexible circuit board, the flexible circuit board is provided with a path of AC trace, a path of grounding trace and eight paths of signal traces, the AC trace is arranged on the front surface of the flexible circuit board and is electrically connected with the dielectric elements, the grounding trace is mainly arranged on the back surface of the flexible circuit board and is electrically connected with the grounding ends of the temperature sensors, and the eight paths of signal traces are electrically connected with the grounding ends of the temperature sensors. And the eight paths of signal traces are also mainly arranged on the back surface of the flexible circuit board and are electrically connected with the signal ends of the temperature sensors respectively. According to the tumor electric field treatment device and the electrode patch, the temperature sensor is selectively arranged, so that the temperature measurement requirement can be met, and the overall wiring scheme can be simplified.

Description

Technical Field

[0001] The present invention relates to a tumor electric field treatment device and an electrode patch thereof, belonging to the technical field of medical equipment. Background Art

[0002] Currently, the main treatments for tumors include surgery, radiotherapy, and chemotherapy, but all have corresponding disadvantages. For example, radiotherapy and chemotherapy can produce side effects and kill normal cells. Using electric fields to treat tumors is also one of the current research and development frontiers. Tumor electric field therapy uses a special electric field generator to generate a low-intensity, medium-high frequency, alternating electric field to interfere with the mitotic process of tumor cells. Studies have shown that tumor electric field therapy is effective in treating diseases such as glioblastoma, non-small cell lung cancer, and malignant pleural mesothelioma. The electric field applied by this treatment method can affect the aggregation of microtubules, prevent spindle formation, inhibit the mitotic process, and induce apoptosis in cancer cells.

[0003] A tumor electric field therapy device used for tumor electric field therapy primarily comprises an electric field generator and an electrode patch electrically connected to the electric field generator. The electrode patch includes an electrode array that transmits an alternating electric field. The electrode array comprises a flexible circuit board (FPCB), multiple dielectric elements disposed on the skin-facing side of the FPCB, and multiple temperature sensors that monitor the temperature of each dielectric element. The FPCB is equipped with several conductive traces to transmit alternating current (AC) signals to each dielectric element and direct current (DC) signals to each temperature sensor. The large number of temperature sensors complicates existing FPCB wiring schemes, significantly impacting their manufacture.

[0004] Therefore, it is indeed necessary to provide an improved electrode patch and tumor electric field treatment device to overcome the problems existing in the above-mentioned electrode patch and tumor electric field treatment device. Summary of the Invention

[0005] The present invention provides a tumor electric field therapy device and an electrode patch thereof. While meeting temperature measurement requirements, a temperature sensor is selectively provided to simplify the wiring scheme of a flexible circuit board.

[0006] The electrode patch of the present invention is realized by the following technical solution: an electrode patch for tumor electric field therapy, comprising an electrode array, wherein the electrode array comprises thirteen electrode units having dielectric elements, the thirteen electrode units being arranged in five rows and five columns, the first row and the last row each having two electrode units and being located on the second column and the fourth column respectively, the middle three rows each having three electrode units and being located on the first column, the third column and the fifth column respectively, wherein the four electrode units located at the corners of the electrode array, the two electrode units located in the center area of ​​the electrode array and the electrode units located at the edge of the electrode array are arranged in five rows and five columns respectively. A temperature sensor is respectively provided on each of the two electrode units at the corner; the electrode array includes a flexible circuit board, and the flexible circuit board is provided with one AC trace, one ground trace and eight signal traces. The AC trace is arranged on the front of the flexible circuit board and is electrically connected to each of the dielectric elements. The ground trace is mainly arranged on the back of the flexible circuit board and passes through the corresponding main body to be electrically connected to the ground end of each of the temperature sensors. The eight signal traces are also mainly arranged on the back of the flexible circuit board and pass through the corresponding main body to be electrically connected to the signal end of each of the temperature sensors.

[0007] Furthermore, the flexible circuit board is provided with a plurality of main body portions arranged at intervals, a plurality of connection portions connecting two adjacent main body portions, and a wiring portion, a conductive plate is provided on the front side of the main body portion, and the dielectric element is provided on the front side of the main body portion and is electrically connected to the conductive plate; the front side of the main body portion provided with the temperature sensor is also provided with a ground pad and a signal pad, and the temperature sensor is provided on the front side of the corresponding main body portion and is electrically connected to the ground pad and the signal pad, respectively.

[0008] Furthermore, the connection portion is provided with five gold fingers on the front and back sides thereof, the AC trace extends from a corresponding one of the gold fingers on the front side of the connection portion and extends on the front side of the flexible circuit board; the ground trace extends from a corresponding one of the gold fingers on the back side of the connection portion and mainly extends on the back side of the flexible circuit board.

[0009] Furthermore, four of the signal traces are led out from the four corresponding gold fingers on the front of the wiring part and pass through the wiring part to the back of the wiring part and extend on the back of the flexible circuit board, and another four signal traces are led out from the four corresponding gold fingers on the back of the wiring part and extend on the back of the flexible circuit board.

[0010] Furthermore, a portion of the ground traces are jumpered to the front side of the flexible printed circuit board for layout.

[0011] Furthermore, all the temperature sensors are arranged in a centrosymmetrical manner relative to the center of the matrix formed by the thirteen electrode units.

[0012] Furthermore, the eight electrode units provided with the temperature sensors are respectively located in the first row and second column, the second row and third column, the second row and fifth column, the third row and first column, the third row and fifth column, the fourth row and first column, the fourth row and third column, and the fifth row and fourth column of the electrode array.

[0013] Furthermore, the wiring portion extends downward from the electrode unit located in the fourth row and the third column, and the ground trace and all the signal traces pass through the electrode unit located in the fourth row and the third column.

[0014] Furthermore, it also includes a backing, a plurality of supporting members and a plurality of adhesive members, the electrode array is adhered to the backing, the supporting members are adhered to the backing and arranged around each of the electrode units, and the adhesive members cover each of the supporting members and each of the electrode units; the electrode array is also provided with a plurality of insulating plates fixed on the back of each of the main bodies.

[0015] The present invention is also implemented through the following technical solution: a tumor electric field treatment device, including an electric field generator and the above-mentioned electrode patch electrically connected to the electric field generator.

[0016] The tumor electric field therapy device and electrode patch thereof of the present invention can reduce the number of temperature sensors and simplify the wiring scheme of the flexible circuit board by selectively setting temperature sensors while meeting the temperature measurement requirements. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A three-dimensional combined diagram of electrode patches in one embodiment of the tumor electric field treatment device of the present invention; Figure 2 for Figure 1 Exploded three-dimensional diagram of the electrode patch; Figure 3 for Figure 2 A plan view of the electrode array of the electrode patch; Figure 4 for Figure 3 A three-dimensional exploded view of the electrode array in FIG; Figure 5 for Figure 3 A plan view of the flexible circuit board and temperature sensor of the electrode array; Figure 6 for Figure 5 The front wiring diagram of the flexible circuit board; Figure 7 for Figure 5 The back wiring diagram of the flexible circuit board; Figure 8 for Figure 7 The ground trace wiring diagram on the back side of the flexible circuit board; Figure 9 for Figure 7 The signal trace routing diagram on the back of the flexible circuit board.

[0018] Description of reference numerals: Electrode patch 100, electrode array 1, electrode unit 10, flexible circuit board 11, main body 111, connecting part 112, wiring part 113, gold finger 1131, open space 114, conductive plate 115, conductive core 1151, solder pad 116, grounding pad 1161, signal solder pad 1162, insulating plate 12, dielectric element 13, temperature sensor 14, conductive trace L, AC trace L1, grounding trace L2, signal trace L3, backing 2, support member 3, through hole 31, adhesive member 4, wire 5, heat shrink tubing 51. DETAILED DESCRIPTION

[0019] Exemplary embodiments are described in detail herein, examples of which are illustrated in the accompanying drawings. When the following description refers to the drawings, identical numerals in different figures represent identical or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all embodiments consistent with the present invention. Rather, they are merely examples of devices, systems, apparatus, and methods consistent with certain aspects of the present invention.

[0020] The tumor electric field therapy device of the present invention includes multiple pairs of electrode patches 100 and an electric field generator (not shown) electrically connected to each electrode patch 100. The electric field generator (not shown) provides an alternating current signal and transmits it to each pair of electrode patches 100. After each pair of electrode patches 100 receives the alternating current signal, an alternating current electric field is formed between the two pairs of electrode patches 100. The multiple pairs of electrode patches 100 alternately apply alternating current electric fields in different directions to the patient's tumor area, which can have a certain therapeutic effect on the patient's tumor.

[0021] refer to Figures 1 to 2 As shown, the electrode patch 100 in this embodiment is Figure 1The electrode patch 100 is applied to the patient's torso with the front side facing the patient, and is positioned corresponding to the patient's tumor. The electrode patch 100 comprises an electrode array 1, a backing 2, several supports 3, several adhesives 4, and a conductive wire 5. The electrode array 1 is adhered to the backing 2 and includes several spaced-apart electrode units 10. The supports 3 are adhered to the backing 2 and surround each electrode unit 10 to support the adhesives 4 covering each support 3 and corresponding electrode unit 10. The adhesives 4 directly adhere to the patient's body surface. The conductive wire 5 electrically connects an electric field generator (not shown) to the electrode array 1 to provide an alternating current signal to the electrode array 1. A biocompatible adhesive is applied to the front side of the backing 2, allowing the electrode patch 100 to be tightly adhered to the patient's body surface corresponding to the tumor site. The paired electrode patches 100 apply an alternating electric field to the patient's tumor site, disrupting or preventing mitosis in the patient's tumor cells, thereby achieving the purpose of tumor treatment.

[0022] The backing 2 is a sheet-like material made of a flexible, breathable insulating material. It can be a mesh fabric, preferably a non-woven mesh fabric, which is soft, lightweight, moisture-resistant, and breathable. The electrode array 1 is centrally adhered to the backing 2 using the aforementioned biocompatible adhesive (not shown). The support member 3 is made of a soft material, preferably foam, and is provided with through-holes 31 surrounding the electrode units 10. The adhesive member 4 is double-sided adhesive, preferably a conductive gel, which keeps the skin surface moisturized and relieves localized pressure.

[0023] Combine Figure 3 As shown, from the perspective of spatial distribution, a number of electrode units 10 are arranged in multiple rows and columns, and the electrode array 1 also includes a plurality of connecting parts 112 connecting two adjacent electrode units 10 and a wiring part 113 connected to the electrode unit 10 or the connecting part 112. The wiring part 113 is used to be welded and connected to the wire 5. A plurality of adjacent electrode units 10 are spaced apart and enclosed together to form a plurality of open spaces 114 to allow the skin covered by the electrode patch 100 to breathe freely after the electrode patch 100 is applied to the patient's body surface. Each electrode unit 10 is connected to a plurality of adjacent electrode units 10 through the connecting part 112, wherein the two electrode units 10 in the last row are disconnected to allow the wiring part 113 to pass through. The wiring part 113 is provided with a row of gold fingers 1131 on the front and back of its end, respectively. Each gold finger 1131 is welded and connected to the corresponding wire core (not shown) of the wire 5. The connection between the wiring part 113 and the wire 5 is provided with a heat shrink tubing 51 (see FIG. 1 ). Figure 2 ) to protect the connection.

[0024] refer to Figure 4As shown, from a hierarchical perspective, the electrode array 1 comprises a flexible printed circuit board 11, several insulating plates 12 disposed on the back of the flexible printed circuit board 11, several dielectric elements 13 disposed on the front of the flexible printed circuit board 11, and several temperature sensors 14. The front of the flexible printed circuit board 11 faces the patient's body surface. The flexible printed circuit board 11 comprises several spaced-apart main bodies 111, several aforementioned connecting portions 112 connecting adjacent main bodies 111, and the aforementioned wiring portions 113. A conductive plate 115 is provided on the front of each main body 111. The conductive plate 115 comprises four annular conductive cores 1151. The insulating plate 12 is affixed to the back of the main body 111. The dielectric element 13 is welded to the conductive plate 115 and mounted on the front of the main body 111, electrically connected to the conductive plate 115. The main body 111, insulating plate 12, and dielectric element 13 all have circular sheet-like structures, with their centers aligned, forming the aforementioned electrode unit 10. The insulating plate 12 is optional for the electrode unit 10, meaning that the electrode unit 10 may not have the insulating plate 12. The front of each main body 111 is also provided with a pair of soldering pads 116 located at the center of the conductive plate 115. The temperature sensor 14 is welded to the soldering pads 116 and mounted at the center of the front of the main body 111. A through-hole 131 is correspondingly provided at the center of the dielectric element 13 to accommodate and accommodate the temperature sensor 14. In this embodiment, the temperature sensor 14 is optionally mounted on the corresponding main body 111. The specific arrangement of the temperature sensor 14 will be described in detail later.

[0025] The insulating plate 12 is preferably an epoxy glass cloth laminate. Before welding the dielectric element 13 to the main body 111, it is adhered to the back of the main body 111 with glue. This reinforces the main body 111, improves the flatness of the weld surface between the main body 111 and the dielectric element 13, and enhances the weld quality between the main body 111 and the dielectric element 13. The dielectric element 13 is made of a high-dielectric-constant material, which has the conductive property of blocking direct current while allowing alternating current to pass, ensuring human safety. After welding the dielectric element 13 to the conductive pad 115, a sealant (not shown) is used to seal the periphery of the dielectric element 13. After welding the temperature sensor 14 to the solder pad 116, a sealant is injected through the through-hole 131 of the dielectric element 13 to seal the temperature sensor 14. An electric field generator (not shown) transmits an AC signal to the dielectric element 13 via the flexible printed circuit board 11. The dielectric element 13 receives the AC signal and generates an AC electric field that is applied to the patient. In other embodiments, the dielectric element 13 may also be in other forms, such as a polymer dielectric layer with high dielectric constant and low dielectric loss made of a thin film material with non-fixed crystal orientation, high flexibility and high toughness, which can be formed on the main body 111 by evaporation, sputtering or ion plating vapor deposition, printing, spraying or casting.

[0026] The electric field generator (not shown) provides a DC signal to the temperature sensor 14 through the flexible circuit board 11 and receives a temperature signal fed back by the temperature sensor 14. The temperature sensor 14 is preferably a thermistor, which monitors the temperature of the corresponding electrode unit 10 and feeds back the temperature to the electric field generator (not shown). When the monitored temperature value exceeds the upper limit of the human body's safe temperature, the AC signal is promptly reduced or turned off to prevent the corresponding electrode unit 10 from causing low-temperature burns to the human body; when the detected temperature value is lower than a preset minimum value, the intensity of the AC signal is increased to increase the intensity of the AC electric field and enhance the therapeutic effect.

[0027] In this embodiment, the electrode array 1 is provided with thirteen electrode units 10, which are distributed in an array of five rows and five columns. The first and last rows of the electrode array 1 are each provided with two electrode units 10, located on the second and fourth columns respectively; the middle three rows are each provided with three electrode units 10, located on the first, third and fifth columns respectively. The distribution of the thirteen electrode units 10 is symmetrical in both row and column directions. Figures 5 to 7 As shown, for the convenience of description, the thirteen electrode units 10 are numbered C1 to C13 from top to bottom and from left to right, that is, electrode units C1 and C2 are located in the first row of electrode array 1, electrode units C3, C4, and C5 are located in the second row of electrode array 1, electrode units C6, C7, and C8 are located in the third row of electrode array 1, electrode units C9, C10, and C11 are located in the fourth row of electrode array 1, and electrode units C12 and C13 are located in the fifth row of electrode array 1. Please note that Figures 5 to 7 Although there is no dielectric element 13, the position of each main body 111 is the position of each electrode unit 10, and the arrangement of the main body 111 is the arrangement of each electrode unit 10. Figures 5 to 7 The numbers are indicated above.

[0028] The entire electrode array 1 is roughly octagonal, with eight electrode units C1, C2, C3, C5, C9, C11, C12, and C13 located at the corners of the electrode array 1. Three electrode units C4, C7, and C10 are located in the center of the electrode array 1. The remaining two electrode units C6 and C8 are located at the edges of the electrode array 1. Due to the edge effect during use, the electrode patch 100 has the fastest temperature rise and the highest temperature at the corners, while the electrode units C4, C7, and C10 located in the center have the slowest temperature rise and the lowest temperature. The temperature of the electrode units C6 and C8 located at the edges of the electrode array 1 is between the highest and lowest temperatures.

[0029] In this embodiment, the electrode array 1 is provided with eight temperature sensors 14, which are respectively provided on the electrode units C1, C4, C5, C6, C8, C9, C10, and C13 (for the convenience of observation, the temperature sensors 14 are shown in FIG. Figures 5 to 7 (Shown in blue font in the figure). The eight electrode units 10 where these eight temperature sensors 14 are located include: four electrode units C1, C5, C9, and C13 located at the corners of the electrode array 1; two electrode units C4 and C10 located in the center of the electrode array 1; and two electrode units C6 and C8 located at the edges of the electrode array 1 (not at the corners). That is, the eight electrode units 10 equipped with temperature sensors 14 are located in the first row, second column, second row, third column, second row, fifth column, third row, first column, third row, fifth column, fourth row, first column, fourth row, third column, and fifth row, fourth column of the electrode array 1, respectively. These eight electrode units 10 cover three different locations: the corners, the center, and the edges of the electrode array 1 (not at the corners). The corresponding collected temperature values ​​include the highest value, the lowest value, and the intermediate value, which can more accurately reflect the temperature conditions of each electrode unit 10 of the electrode array 1. A small number of temperature sensors 14 can simultaneously monitor the lowest temperature, the intermediate temperature, and the highest temperature, thereby preventing both high-temperature burns and preventing low electric field strength from affecting the treatment effect. The eight electrode units 10 are also distributed in a centrally symmetrical manner relative to the center of the matrix formed by the entire electrode unit 10 , so that the overall weight distribution of the electrode array 1 is more balanced.

[0030] refer to Figure 6 and Figure 7 As shown, the flexible printed circuit board 11 comprises an insulating substrate (unnumbered) and multiple conductive traces L embedded within the insulating substrate (unnumbered). The multiple conductive traces L include one AC trace L1, one ground trace L2, and eight signal traces L3, for a total of ten conductive traces L. Each row of gold fingers 1131 on the front and back sides of the connection portion 113 has five gold fingers 1131 each, for a total of ten gold fingers 1131. The end of each conductive trace L is electrically connected to the corresponding gold finger 1131.

[0031] The AC trace L1 is provided on the front surface of the flexible printed circuit board 11. It extends from a gold finger 1131 on the front surface of the connection portion 113, then extends along the connection portion 113, the corresponding main body portion 111, and the corresponding connecting portion 112, and is electrically connected to each conductive plate 115. This transmits an AC signal to each conductive plate 115, and then to each dielectric element 13. Each dielectric element 13 receives the AC signal, thereby generating a therapeutic AC electric field between the paired electrode patches 100.

[0032] Specific reference Figure 6As shown, the specific routing of AC trace L1 is as follows: AC trace L1 extends upward from connection portion 113 to electrode unit C10, passes through electrode unit C9 to electrode unit C12, then returns from electrode unit C12 to pass through electrode unit C9 to electrode unit C6, then returns from electrode unit C6 to pass through electrode unit C9 to electrode unit C10; then passes from electrode unit C10 to electrode unit C10, passes through electrode units C7, C4, and C3, and then returns from electrode unit C1 to pass through electrode units C3, C4, and C5 to electrode unit C2, then returns from electrode unit C2 to pass through electrode units C5, C4, C7, C10, and C11 to electrode unit C8, then returns from electrode unit C8 to pass through electrode unit C11 to electrode unit C13, and finally returns from electrode unit C13 to pass through electrode unit C11 and back to electrode unit C10. AC trace L1 is electrically connected to the corresponding conductive core 1151 when passing through each electrode unit 10. The connecting portion 112 provided with the AC trace L1 has two sections of AC trace L1 disposed on opposite sides thereof. The two sections of AC trace L1 extend along the length direction of the connecting portion 112 to connect the conductive cores 1151 on different main bodies 111 .

[0033] Each pair of pads 116 includes a ground pad 1161 and a signal pad 1162. Each temperature sensor 14 has a ground terminal (not shown) and a signal terminal (not shown). The ground pad 1161 is welded to the ground terminal (not shown), and the signal pad 1162 is welded to the signal terminal (not shown). Figure 7 As shown, the ground trace L2 is primarily located on the back of the flexible circuit board 11. It extends from a corresponding gold finger 1131 on the back of the connection portion 113, then along the connection portion 113, the corresponding main portion 111, and the corresponding connecting portion 112. It is electrically connected to the ground pads 1161 on the corresponding main portion 111 on which the temperature sensor 14 is located, thereby grounding all of the ground pads 1161 electrically connected to each temperature sensor 14. Note that the majority of the ground trace L2 is located on the back of the flexible circuit board 11, but a small portion needs to be extended to the front of the flexible circuit board 11 for jumpering. That is, a small portion of the ground trace L2 is located on the front of the flexible circuit board 11 (see FIG. 1 ). Figure 6 red line in the image).

[0034] Key References Figure 8 Combined with Figure 6As shown in FIG, it is a wiring diagram of the ground trace L2 on the flexible circuit board 11. The following is a specific wiring scheme of the ground trace L2 from the front perspective of the flexible circuit board 11: the ground trace L2 is led out from a corresponding gold finger 1131 on the back side of the terminal end of the connection portion 113 and extends upward to the electrode unit C10 and is electrically connected to the corresponding ground pad 1161 of the electrode unit C10. Then, it is divided into three branches at the electrode unit C10, one of which passes through the electrode unit C10 and is arranged on the front side of the flexible circuit board 11 and then extends to the right to the electrode unit C11. At the electrode unit C11, it passes back to the back side of the flexible circuit board 11 and is divided into two branches, which extend to the electrode unit C8 and the electrode unit C13 respectively and are connected to the corresponding ground pads 1161 on the electrode unit C8 and the electrode unit C13 respectively; the other branch passes through the electrode unit C10 from the electrode unit C10 and is arranged on the flexible circuit board 11. The front side of the flexible circuit board 11 then extends leftward to electrode unit C9. At electrode unit C9, it passes back to the back side of the flexible circuit board 11 and connects to the corresponding ground pad 1161 on electrode unit C9. From electrode unit C9, it continues upward to electrode unit C6 and connects to the corresponding ground pad 1161 on electrode unit C6. The last branch, after jumping at electrode unit C10, continues on the back side of the flexible circuit board 11 and extends upward through electrode unit C7 to electrode unit C4, connecting to the corresponding ground pad 1161 on electrode unit C4. It then splits into two branches at electrode unit C4. One of the two branches extends rightward to electrode unit C5 and connects to the corresponding ground pad 1161 on electrode unit C5. The other branch extends leftward through electrode unit C3 to electrode unit C1 and connects to the corresponding ground pad 1161 on electrode unit C1. Note that ground trace L2 must run from the back side of the corresponding main body 111 through the main body 111 to its front side and connect to the corresponding ground pad 1161.

[0035] refer to Figure 9 Combined with Figure 7 As shown, eight signal traces L3 are primarily located on the back side of the flexible printed circuit board 11. Four of the signal traces L3 are led out from four gold fingers 1131 on the front side of the connection portion 113 and run through the connection portion 113 to the back side of the connection portion 113. Another four signal traces L3 are led out from four gold fingers 1131 on the back side of the connection portion 113. In total, all eight signal traces L3 are located on the back side of the flexible printed circuit board 11. Each signal trace L3 extends along the connection portion 113, the corresponding main body portion 111, and the corresponding connecting portion 112 to the back side of the main body portion 111 of the corresponding electrode unit 10 equipped with the temperature sensor 14. The traces then pass through the corresponding main body portion 111 to electrically connect to the corresponding signal pad 1162, thereby transmitting a DC signal to each signal pad 1162 electrically connected to the temperature sensor 14.

[0036] The following is a detailed description of the specific wiring scheme of the signal traces L3 from the front view of the flexible circuit board 11: the eight signal traces L3 all extend upward from the connection part 113 to the electrode unit C10 and then continue to extend from the electrode unit C10, specifically including: one signal trace L3 is led out from a corresponding gold finger 1131 at the end of the back of the connection part 113 and extends upward to the electrode unit C10 and then electrically connected to the signal pad 1162 of the electrode unit 10; one signal trace L3 is led out from a corresponding gold finger 1131 at the end of the front of the connection part 113 to the back of the connection part 113 and extends upward to the electrode unit C10; After the electrode unit C10, it continues to extend to the right through the electrode unit C11 to the electrode unit C8 and is connected to the signal pad 1162 of the electrode unit C8; a signal trace L3 is led out from a corresponding gold finger 1131 at the end of the front side of the wiring portion 113, passes through the back side of the wiring portion 113 and extends upward to the electrode unit C10, and then continues to extend to the right through the electrode unit C11 to the electrode unit C13 and is connected to the signal pad 1162 of the electrode unit C13; a signal trace L3 is led out from a corresponding gold finger 1131 at the end of the back side of the wiring portion 113 and extends upward to the electrode unit C10, Then it continues to extend to the left to the electrode unit C9 and is connected to the signal pad 1162 of the electrode unit C9; a signal trace L3 is led out from the corresponding gold finger 1131 at the end of the back of the wiring part 113 and extends upward to the electrode unit C10, and then continues to extend to the left through the electrode unit C9 to the electrode unit C6 and is connected to the signal pad 1162 of the electrode unit C6. A signal trace L3 is led out from the corresponding gold finger 1131 at the end of the front of the wiring part 113 and passes through the back of the wiring part 113 and extends upward through the electrode units C10 and C7 to the electrode unit C4 and is connected to the signal pad 1162 of the electrode unit C4. Signal trace L3 is connected to signal pad 1162; a signal trace L3 is led from a corresponding gold finger 1131 at the front end of the connection portion 113, passes through the back of the connection portion 113, and extends upward through electrode units C10, C7, and C4, then extends rightward to electrode unit C5, and then connects to signal pad 1162 of electrode unit C5; a signal trace L3 is led from a corresponding gold finger 1131 at the back end of the connection portion 113, extends upward through electrode units C10, C7, and C4, then extends leftward through electrode unit C3 to electrode unit C1, and then connects to signal pad 1162 of electrode unit C1. Please note that signal trace L3 must run from the back of the main body 111 of each corresponding electrode unit 10, pass through the main body 111, and connect to the corresponding signal pad 1162 on its front.

[0037] The electrode patch 100 of the present invention selects eight electrode units 10 out of the thirteen electrode units 10 to be provided with temperature sensors 14, and the specific locations of the temperature sensors 14 involve the corners, central areas and non-corner edges of the electrode array 1, which can monitor the maximum value, minimum value and intermediate value of the temperature in each electrode unit 10, thereby meeting the temperature measurement requirements and simplifying and reducing the number of temperature sensors 14, thereby simplifying the overall wiring scheme.

[0038] The above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An electrode patch for use in electric field therapy of tumors, comprising an electrode array comprising thirteen electrode units having dielectric elements, the thirteen electrode units being arranged in five rows and five columns, with the first and last rows each having two electrode units located in the second and fourth columns, respectively, and the middle three rows each having three electrode units located in the first, third, and fifth columns, respectively. The invention is characterized in that: A temperature sensor is respectively provided on the four electrode units located at the corners of the electrode array, the two electrode units located in the central area of ​​the electrode array, and the two electrode units located at the edge non-corners of the electrode array; the electrode array includes a flexible circuit board, and the flexible circuit board is provided with one AC trace, one ground trace, and eight signal traces. The AC trace is arranged on the front side of the flexible circuit board and is electrically connected to each of the dielectric elements. The ground trace is mainly arranged on the back side of the flexible circuit board and is electrically connected to the ground end of each of the temperature sensors. The eight signal traces are also mainly arranged on the back side of the flexible circuit board and are electrically connected to the signal ends of each of the temperature sensors.

2. The electrode patch according to claim 1, characterized in that The flexible circuit board is provided with a plurality of main body parts arranged at intervals, a plurality of connection parts connecting two adjacent main body parts, and a wiring part. A conductive pad is provided on the front side of the main body part, and the dielectric element is provided on the front side of the main body part and is electrically connected to the conductive pad; the front side of the main body part provided with the temperature sensor is also provided with a ground pad and a signal pad. The temperature sensor is provided on the front side of the corresponding main body part and is electrically connected to the ground pad and the signal pad, respectively.

3. The electrode patch according to claim 2, characterized in that: The connection portion is provided with five gold fingers on its front and back, respectively. The AC trace extends from a corresponding one of the gold fingers on the front of the connection portion and extends on the front of the flexible circuit board; the ground trace extends from a corresponding one of the gold fingers on the back of the connection portion and mainly extends on the back of the flexible circuit board.

4. The electrode patch according to claim 3, characterized in that: Four of the signal traces are led out from the four corresponding gold fingers on the front of the wiring part and pass through the wiring part to the back of the wiring part and extend on the back of the flexible circuit board. Another four signal traces are led out from the four corresponding gold fingers on the back of the wiring part and extend on the back of the flexible circuit board.

5. The electrode patch according to claim 3, characterized in that: A portion of the ground traces is routed to the front side of the flexible circuit board.

6. The electrode patch according to claim 2, characterized in that: All the temperature sensors are arranged in a centrally symmetrical manner relative to the center of the matrix formed by the thirteen electrode units.

7. The electrode patch according to claim 6, characterized in that: The eight electrode units provided with the temperature sensors are respectively located in the first row and second column, the second row and third column, the second row and fifth column, the third row and first column, the third row and fifth column, the fourth row and first column, the fourth row and third column, and the fifth row and fourth column of the electrode array.

8. The electrode patch according to claim 7, characterized in that: The connection portion extends downward from the electrode unit located in the fourth row and third column, and the ground trace and all the signal traces pass through the electrode unit located in the fourth row and third column.

9. The electrode patch according to claim 7, characterized in that: It also includes a backing, a number of supporting members and a number of adhesive members. The electrode array is adhered to the backing, the supporting members are adhered to the backing and arranged around each of the electrode units, and the adhesive members cover each of the supporting members and each of the electrode units. The electrode array is also provided with a number of insulating plates fixed on the back of each of the main bodies.

10. A tumor electric field treatment device, characterized in that: The invention comprises an electric field generator and an electrode patch according to any one of claims 1 to 9 electrically connected to the electric field generator.

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