Meal replacement special meal functional nutritional food formula design based on specific total nutrient formula

Abstract

The invention provides a special meal replacement functional nutritional food formula design based on a specific total nutrient formula, and belongs to the technical field of formula foods for special medical purposes. According to the product, a marine collagen tripeptide and fucoidan compound is innovatively used as a core matrix, and a medicine and food homologous traditional Chinese medicine superfine powder technology is combined, so that a special diet formula with a triple sugar control mechanism (delaying carbon and water absorption, improving insulin sensitivity and regulating intestinal flora) is formed. The formula comprises the following core components in percentage by weight: 20 to 35 percent of marine collagen tripeptide-fucoidan compound, 15 to 25 percent of mulberry leaf-rhizoma polygonati-radix puerariae extract compound, 10 to 15 percent of medium-chain triglyceride microemulsion, 5 to 10 percent of resistant dextrin-arabinose composition, 3 to 5 percent of compound probiotics (lactobacillus plantarum and lactobacillus rhamnosus) and the like. And low-temperature directional enzymolysis, microencapsulation embedding and nano-emulsification technologies are adopted, so that the bioavailability of the active ingredients is ensured. Clinical tests prove that the formula can significantly improve blood sugar and blood fat metabolism indexes of people suffering from obesity and prediabetes, meets daily basic nutritional requirements, and accords with GB 29922-2013 special medical purpose formula food standards.

Description

Technical Field

[0001] The present invention belongs to the technical field of the intersection of special medical purpose formula foods and functional foods, and specifically relates to a formula design of a meal replacement special functional nutritional food based on specific complete nutritional formula components, which is particularly suitable for nutritional intervention for people with metabolic abnormalities such as obesity and prediabetes. Background Art

[0002] As lifestyles change, the global prevalence of metabolic syndrome continues to rise. The overweight / obesity rate among Chinese adults has reached 50.7%, and the proportion of people with prediabetes is as high as 35.2%. Traditional meal replacement products face three major technical bottlenecks: 1) nutritional imbalance, with long-term use leading to micronutrient deficiencies; 2) single-function functionality, focusing solely on calorie control while ignoring metabolic regulation; and 3) poor taste and low user compliance. Existing patent CN115644389A utilizes a traditional medicinal and edible formula but lacks the precise design of modern nutritional principles. CN112674325A, while focusing on protein supplementation, does not address the regulation of carbohydrate metabolism. CN108450930A utilizes ultrafine grinding technology, but the bioavailability of the active ingredient still needs to be improved.

[0003] Marine bioactive substances, due to their unique structural characteristics and physiological functions, exhibit significant advantages in metabolic regulation. Research has shown that marine collagen tripeptides can improve insulin sensitivity by activating the AMPK pathway; that fucoidan can selectively promote the proliferation of bifidobacteria and regulate intestinal flora; and that sea cucumber saponins have significant PPARγ agonist effects. However, a systematic solution for the application of these active ingredients in specialty dietary supplements has yet to be established.

[0004] Based on the concept of "medicine and food have the same origin", this research and development team innovatively combines marine active substances with traditional Chinese medicine ingredients. Through a multi-target synergistic mechanism, they have developed a special meal replacement food with both nutritional support and metabolic regulation functions, solving the technical defects of existing products. Summary of the Invention

[0005] The purpose of the present invention is to provide a functional nutritious food for meal replacement based on a specific complete nutritional formula. Its core technological breakthroughs include: 1. The first marine collagen tripeptide-fucoidan complex is used as the core matrix, and the bioavailability is improved through molecular self-assembly technology; 2. Develop a mulberry leaf-polygonatum-pueraria root three-phase extract complex to achieve α-glucosidase inhibition, insulin sensitization, and β-cell protection Triple effect; 3. Design a probiotic-prebiotic-traditional Chinese medicine polysaccharide synergistic system to significantly improve intestinal colonization efficiency; 4. Apply medium-chain triglyceride nanoemulsification technology to achieve rapid energy supply without fat accumulation.

[0006] The main technical solutions of the present invention's formula are as follows: 1. Marine active compound system: It is composed of marine collagen tripeptide (molecular weight ≤ 1000Da) and fucoidan (fucose content ≥ 30%), compounded in a specific ratio to form a self-assembling network structure, which can delay gastric emptying and promote intestinal peptide YY secretion, enhancing satiety; 2. Traditional Chinese Medicine Efficacy Module: This module selects three traditional Chinese medicines with both medicinal and edible properties: mulberry leaves (rich in 1-deoxynojirimycin), polygonatum (containing polygonatum polysaccharides), and kudzu root (containing puerarin). Supercritical CO2 extraction combined with targeted enzymatic hydrolysis technology yields an extract complex with intact active sites, enabling multi-target regulation of glucose and lipid metabolism. 3. Energy Supply System: Nano-emulsified medium-chain triglycerides (C8-C12 ≥90%) are combined with resistant dextrin (degree of polymerization 10-30) and L-arabinose (purity ≥99%) to form a low-GI (≤30) carbohydrate combination, providing sustained energy without causing blood sugar fluctuations. 4. Microecological Regulation System: Contains two patented strains of Lactobacillus plantarum CGMCC No.1258 and Lactobacillus rhamnosus ATCC53103, protected by three-layer microencapsulation technology (calcium alginate-chitosan-whey protein), with a gastric acid survival rate ≥95% and an intestinal release rate ≥90%.

[0007] The beneficial effects of the present invention include: 1. Comprehensive metabolic regulation: Simultaneously acting on three key links: carbohydrate digestion and absorption, insulin signaling, and intestinal microecology; 2. Nutritionally balanced and complete: Meets the Chinese Dietary Reference Intakes (DRIs) and can be used as a single source of nutrition; 3. User experience optimization: significantly improve palatability through flavor masking technology and texture improvement; 4. Safety Assurance: All raw materials are from the GRAS substances and the food and medicine catalog, and their safety has been confirmed by acute toxicity tests (LD50>10g / kg) and 90-day feeding tests. DETAILED DESCRIPTION

[0008] The present invention is described in detail below with reference to the embodiments, but the protection scope of the present invention is not limited thereto.

[0009] Example 1: Powder Formulation Formula composition (weight percentage): - Marine collagen tripeptide-fucoidan complex 25%; - Mulberry leaf-Polygonatum-Pueraria root extract complex 20%; - Medium chain triglyceride microemulsion 12%; - Resistant dextrin-arabinose combination 8%; - Complex probiotics 4%; - Multivitamin mineral premix 4%; - Water-soluble dietary fiber 7%; - Functional excipients 3%; - Other excipients 17%; Preparation process: 1) Mix marine collagen tripeptide and fucoidan at a ratio of 3:1, add 0.5% sodium alginate, and ultrasonicate at 45°C for 30 minutes to form a complex; 2) After supercritical CO2 extraction, mulberry leaves, polygonatum, and kudzu root were enzymatically hydrolyzed with a complex enzyme (cellulase:pectinase = 1:2) at 40°C for 4 hours and spray-dried to obtain an extract complex; 3) dry-mixing the resistant dextrin, arabinose and water-soluble dietary fiber; 4) Medium-chain triglycerides, lecithin, and β-cyclodextrin were homogenized under high pressure (100 MPa) to prepare nanoemulsions; 5) Mix the above components and spray dry them at low temperature using a three-fluid nozzle; 6) Finally, add microencapsulated probiotics and pack with nitrogen.

[0010] Example 2: Liquid Formulation Formula composition (weight percentage): - Marine collagen tripeptide-fucoidan complex 30%; - Mulberry leaf-Polygonatum-Pueraria root extract complex 15%; - Medium chain triglyceride microemulsion 15%; - Complex probiotics 3%; - Other components 37%; Preparation characteristics: 1) Ultra-high pressure homogenization (150 MPa) was used to treat the lipid phase; 2) Add 0.1% gellan gum as a stabilizer; 3) Aseptic filling after UHT sterilization (137℃ 4s).

[0011] Example 3: Solid Energy Bar Formula composition (weight percentage): - Marine collagen tripeptide-fucoidan complex 20%; - Mulberry leaf-Polygonatum-Pueraria root extract complex 25%; - Functional excipients 5%; - Other components 50%.

[0012] Process characteristics: 1) Using low temperature molding technology (≤50℃); 2) Add microencapsulated probiotics; 3) Apply a cocoa butter-based coating on the outside. clinical trials

[0013] A randomized controlled trial (n=120) conducted by the metabolic disease department of a hospital showed that: - Body weight: average reduction of 7.8±2.1kg over 12 weeks (p<0.01); - Waist circumference: average reduction of 8.2±3.4cm (p<0.01); - Fasting blood glucose: decreased by 1.5±0.6mmol / L (p<0.05); - The number of intestinal bifidobacteria: increased by 2-3 orders of magnitude; - Nutritional indicators: All maintained within normal range. Industrial Applicability

[0014] This product has completed pilot scale-up and complies with the requirements of GB 29922-2013, "General Rules for Formulated Foods for Special Medical Purposes." It has also passed stability testing (all indicators passed the six-month accelerated test). As a core product in the "Yishi Jiashen" series, it has been clinically tested in 10 Class A tertiary hospitals, achieving a 92% customer satisfaction rating. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] (1). Figure 1 shows the four-fold mechanism of action of the present invention: 1) Marine collagen tripeptide-fucoidan complex delays gastric emptying; 2) Mulberry leaf extract inhibits α-glucosidase; 3) Polygonatum sibiricum polysaccharide improves insulin sensitivity; 4) Probiotics regulate intestinal flora; (2) Figure 2 shows a scanning electron microscope image (×5000) of the marine collagen tripeptide-fucoidan complex, showing the formed three-dimensional network structure; (3). Figure 3 is a micrograph of three-layer microencapsulated probiotics (fluorescence staining), showing the intact capsule structure and distribution of live bacteria; (4). Figure 4 shows the weight change curves of the experimental group and the control group in the clinical trial (12-week follow-up data). Remarks

[0016] The invention has completed 9 months of uninterrupted comprehensive animal experiments in a national animal laboratory of a hospital and has passed the genetic testing work of a genetic testing unit.

Claims

1. A functional nutritious food for meal replacement based on a specific complete nutritional formula, characterized in that Contains the following components in weight percentage: - Marine collagen tripeptide-fucoidan complex 20-35%; - Mulberry leaf-Polygonatum-Pueraria root extract complex 15-25%; - Medium chain triglyceride microemulsion 10-15%; - Resistant dextrin-arabinose combination 5-10%; - Complex probiotics (Lactobacillus plantarum CGMCC No. 1258 + Lactobacillus rhamnosus ATCC 53103) 3-5%; - Multivitamin mineral premix 3-5%; - Water-soluble dietary fiber (inulin + oligofructose) 5-8%; - Functional excipients (white kidney bean extract + mulberry polysaccharide) 2-4%; 2. The meal replacement special dietary functional nutritional food according to claim 1, characterized in that The marine collagen tripeptide-fucoidan complex is prepared by the following method: marine collagen tripeptide with a molecular weight of ≤1000Da and fucoidan (fucose content ≥30%) are mixed in a ratio of 3:1, 0.5% sodium alginate is added as a stabilizer, and ultrasonic treatment is performed at 45°C for 30 minutes to form a complex.

3. The meal replacement special dietary functional nutritional food according to claim 1, characterized in that The mulberry leaf-polygonatum-kudzu root extract complex is prepared by supercritical CO2 extraction combined with low-temperature enzymatic hydrolysis technology, and contains three active ingredients: mulberry leaf polysaccharide (≥15%), polygonatum saponin (≥5%) and puerarin (≥8%), with a particle size of ≤50μm.

4. The meal replacement special dietary functional nutritional food according to claim 1, characterized in that The medium-chain triglyceride microemulsion is prepared by high-pressure homogenization technology, has an average particle size of ≤200 nm, and contains C8-C12 medium-chain fatty acid triglycerides, lecithin and β-cyclodextrin (weight ratio of 8:1:1).

5. The meal replacement special dietary functional nutritional food according to claim 1, characterized in that The compound probiotics are embedded using a three-layer microencapsulation technology, with the outer layer being a calcium alginate-chitosan composite membrane, the middle layer being a whey protein isolation layer, and the inner layer being a probiotic-prebiotic (galacto-oligosaccharide) complex, and the survival rate in a gastric acid environment is ≥95%.

6. The method for preparing the meal replacement functional nutritional food according to claim 1, characterized in that The following steps are involved: a) premixing the marine collagen tripeptide-fucoidan complex with the mulberry leaf-polygonatum-kudzu root extract complex at 40-45°C; b) dry-mixing the resistant dextrin-arabinose combination with the water-soluble dietary fiber and then adding the mixture to step a); c) homogenizing the medium-chain triglyceride microemulsion and the functional excipients in an emulsifier; d) mixing the products of steps b) and c) and spray drying at low temperature (inlet air temperature ≤ 60°C); e) Finally, add the microencapsulated compound probiotics, mix and package in an environment with a relative humidity of ≤30%.

7. The preparation method according to claim 6, characterized in that The low-temperature spray drying adopts three-fluid nozzle technology, the atomization pressure is 0.8-1.2 MPa, and the material temperature is always controlled below 45°C.

8. Use of the meal replacement functional nutritional food according to claim 1 in the preparation of a medical food for improving the nutritional status of patients with metabolic syndrome, wherein the metabolic syndrome includes obesity, prediabetes and insulin resistance.

9. The meal replacement special dietary functional nutritional food according to claim 1, characterized in that Its glycemic index (GI) is ≤30, its protein digestibility-corrected amino acid score (PDCAAS) is ≥0.9, and it provides 300-350kcal of energy per 100g. It can be used as a single source of nutrition for people with metabolic abnormalities.

10. The packaging form of the meal replacement special dietary functional nutritional food according to claim 1, characterized in that It includes 20g strip powder packaging, 250ml ready-to-drink liquid packaging or 30g solid energy bar format. The powder is packaged in nitrogen-filled aluminum foil composite film, and the liquid product is aseptically filled in HDPE bottles.

Images