Multifunctional antibacterial care solution containing silicon component and preparation method of multifunctional antibacterial care solution

Abstract

The invention discloses a multifunctional antibacterial care solution containing a silicon component and a preparation method of the multifunctional antibacterial care solution, and relates to the technical field of biomedical materials and skin care, in particular to an antibacterial care solution taking metasilicic acid as a main component and a preparation method of the antibacterial care solution. The antibacterial care solution comprises the following components: metasilicic acid (H2SiO3), sodium ions (Na < + >), calcium ions (Ca < 2 + >), a ginseng extract, a natural plant extract compound, ethanol and deionized water, the plant extracts can be prepared by adopting a water extraction, alcohol extraction or modern supercritical extraction process, the integrity and the functional stability of active substances are kept, and the mildness and the efficacy of the antibacterial care solution are ensured to be considered. Through the synergistic effect of metasilicic acid and natural plant extracts, multiple functions of rapid hemostasis, deep bacteriostasis, wound repair, light aging protection, problem muscle management, HPV infection auxiliary intervention and the like are achieved, and the bioavailability and functional stability of the product are further improved through the nanoscale permeation and triple barrier technology.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedical materials and skin care, and in particular to an antibacterial care solution with metasilicic acid as a main component and a preparation method thereof. Background Art

[0002] Common antibacterial skincare products currently on the market, such as alcohol and iodine tincture, offer strong antibacterial properties, but they can be irritating, have limited functionality, and exhibit short-lasting effects. This is particularly true for intimate care, children, and those with sensitive skin. Furthermore, with the increasing incidence of human papillomavirus (HPV) infection, the market urgently needs safe, natural, and multifunctional skincare products that offer antibacterial, protective, and repair-promoting properties while also assisting in combating viral infections by regulating the microbiome and immune system.

[0003] The skin, the largest organ in the human body, serves as both a physical barrier and the first line of defense for the immune system. With increasing environmental pollution, the prevalence of immune diseases, and a faster pace of life, various skin injuries, bacterial infections, acne-prone skin, and hormone-induced acne are becoming increasingly prominent, placing higher demands on the market for safe, comprehensive, and effective skincare products.

[0004] Traditional antibacterial care products such as alcohol, iodine, and hydrogen peroxide have certain bactericidal properties, but have the following shortcomings:

[0005] 1. Highly irritating and interfering with tissue repair: Alcohol-based disinfectants may irritate the wound surface while sterilizing, delaying healing and even causing scar formation;

[0006] 2. Single function, unable to provide systematic care: Traditional products often only have a sterilization function, lacking comprehensive functions such as repair, anti-inflammatory, antioxidant and barrier regulation, and cannot meet the care needs of sensitive skin or special areas (such as private parts);

[0007] 3. Inconvenient to use and pungent odor: Some product packaging is not portable, cumbersome to open, and has a strong odor, resulting in a poor user experience;

[0008] 4. Weak ability to intervene in viral infections: Especially in terms of persistent HPV infection in women's private parts, there is currently a lack of a product that can provide both gentle care and auxiliary virus clearance functions. Summary of the Invention

[0009] The purpose of the present invention is to address the defects and shortcomings of the existing technology and provide a multifunctional antibacterial care solution containing silicon ingredients and a preparation method thereof. It utilizes the synergistic effect of metasilicic acid and natural plant extracts to achieve multiple functions such as rapid hemostasis, deep antibacterial, wound repair, photoaging protection, problem skin management, and auxiliary intervention for HPV infection, and improves efficacy and stability through nano-level penetration and triple barrier technology.

[0010] To achieve the above purpose, a multifunctional antibacterial care solution containing silicon contains the following components by mass percentage: metasilicic acid (H2SiO3): 0.25%-0.28% (2500-2800ppm); sodium ion (Na + ):0.002%–0.01%; calcium ion (Ca 2+ ): 0.00016%–0.00075%; ginseng extract: 0.003%; natural plant extract blend: 20%–30%; ethanol: 70%–80%; the balance is deionized water: the total amount is adjusted to 100%.

[0011] The natural plant extract compound includes, but is not limited to, Chinese herbal medicines such as angelica, astragalus, licorice, mugwort, safflower, notopterygium wilfordii, angelica pubescens, acanthopanax bark, radix polygoni avicularis, eucommia bark, and notoginseng. All of the above plant extracts can be produced using water extraction, alcohol extraction, or modern supercritical extraction processes to maintain the integrity and functional stability of the active substances, ensuring the mildness and efficacy of the antibacterial care solution. This compound works synergistically through the four mechanisms of "clearing heat and detoxifying, promoting blood circulation and relieving pain, enhancing immunity, and repairing and regenerating muscles": This compound achieves both surface sterilization and deep repair, enhancing defense against HPV infection in women's intimate care, improving microcirculation, promoting collagen synthesis, and enhancing the overall barrier function of the skin.

[0012] A preparation method for a multifunctional antibacterial nursing solution containing silicon components comprises the following steps: mixing ethanol and deionized water to form a base solvent; adding a metasilicic acid mother liquor and stirring evenly; adding a sodium calcium ion buffer solution to maintain a pH value of approximately 7.5; adding the aforementioned plant extracts to the mixed solution, stirring at room temperature for 60 minutes; filtering through a 0.22 μm sterile filter; and filling into a medical ampoule bottle and self-pressurizing packaging.

[0013] The technical foundation of this invention stems from the active application of metasilicic acid (H2SiO3) in the biomedical field. Metasilicic acid is a natural trace mineral element with unique ion binding and film-forming properties in its molecular structure, exhibiting multiple biological activities in the areas of skin wound care, immune regulation, and microecological balance. Combining modern spray technology with traditional Chinese medicine plant extract compounding techniques, this invention has created a multifunctional care system with a trinity mechanism of "physical protection + biological regulation + immune support."

[0014] Metasilicic acid (H2SiO3) is the core functional ingredient of the present invention, possessing excellent film-forming properties and biological activity. Upon contact with skin wounds or mucous membranes, it rapidly forms a uniform protective film, not only acting as a physical barrier to effectively block the invasion of bacteria and pollutants, but also activating the metabolic function of skin tissue cells, promoting collagen synthesis, and accelerating the wound repair process. Simultaneously, metasilicic acid can stimulate the activity of immune cells such as macrophages and T cells, enhancing local immunity and assisting in the clearance of virus-infected cells, demonstrating a certain ability to intervene in persistent HPV infection.

[0015] Sodium ion (Na + ) is mainly used in the present invention to maintain liquid electrolyte balance, regulate osmotic pressure, and enhance the diffusion and absorption efficiency of silicon and plant extracts between the surface and basal layers of the skin.

[0016] Calcium ions (Ca 2+ ) As an important factor in intercellular adhesion and skin barrier stability, it helps maintain the structural integrity of the epidermal stratum corneum, improves local hemostasis, and enhances the tolerance of skin tissue to external stimuli.

[0017] Ethanol is an antibacterial auxiliary material with a concentration controlled between 70% and 80%. It has both disinfection and sterilization as well as solubilization effects. It can effectively kill common pathogenic microorganisms such as bacteria and fungi on the skin surface, while helping the active ingredients to be more evenly distributed.

[0018] Angelica extract has the functions of promoting blood circulation and nourishing blood, regulating microcirculation, promoting the metabolism of damaged tissues, accelerating wound healing, reducing scar formation, and is suitable for chronic injuries and mucosal repair.

[0019] Astragalus extract is a recognized natural immune enhancer with multiple functions such as replenishing qi and strengthening the exterior, anti-oxidation, and antiviral. In the present invention, it can enhance the resistance of the skin and mucous membrane areas and assist in clearing the infection sources of viruses such as HPV.

[0020] Licorice extract has the effects of clearing heat and detoxifying, anti-inflammatory and analgesic. It also has strong soothing properties, which can reduce the irritation of other ingredients to sensitive skin and enhance the overall mildness and skin feel of the preparation.

[0021] Mugwort extract contains volatile oils and a variety of antibacterial ingredients, which can effectively relieve itching and inhibit the reproduction of pathogens. It has the characteristics of removing dampness and cold, warming the meridians and stopping bleeding. It is suitable for women's private parts and humid skin environments.

[0022] Safflower extract has the functions of promoting blood circulation, anti-oxidation and anti-inflammation, which helps to improve the local circulation of the wound, enhance the nutrient supply, prevent melanin deposition and stain formation, and assist in preventing post-wound pigmentation.

[0023] Qianghuo extract mainly has the effects of dispelling wind and dampness, relieving pain and reducing swelling, and has a good auxiliary effect when used for sports injuries, joint discomfort and skin inflammatory reactions.

[0024] The function of Angelica dahurica extract is similar to that of Notopterygium wilfordii, and can enhance its anti-rheumatic and analgesic effects, and has a relieving effect on deep skin discomfort such as muscle soreness, redness, swelling and heat.

[0025] Acanthopanax cortex extract can strengthen muscles and bones, regulate skin barrier function, and enhance cell tolerance. It is suitable for people with low skin immunity under external stimulation and can improve the skin microecological environment.

[0026] The extract of Radix Ligusticum chuanxiong has the pharmacological properties of dispersing blood stasis, relieving pain, and having antibacterial and anti-inflammatory effects. It is particularly suitable for auxiliary treatment in the early stages of sprains, bruises, and acute trauma.

[0027] Eucommia extract can nourish the liver and kidneys, strengthen the muscles and bones, and also has certain anti-inflammatory and antibacterial effects. It has regulatory and supporting functions in repairing local tissue damage caused by HPV or other microorganisms.

[0028] Panax notoginseng extract is a traditional hemostatic and blood-activating medicine. It has the advantages of rapid hemostasis, promotion of granulation tissue growth and shortening of healing period during wound treatment.

[0029] Ginseng extract is rich in ginsenosides and a variety of active substances, which can enhance cell vitality, improve blood circulation, enhance the skin's self-repair and regeneration ability, and enhance the overall nutritional and immune support effects of the care solution.

[0030] Deionized water is the base solvent used to adjust the pH value of the solution, dissolve various components and ensure the clarity and permeability of the liquid.

[0031] When the metasilicic acid in this invention comes into contact with a wound or damaged skin, it quickly forms a stable silicate gel membrane with cations in body fluids, sealing the wound and effectively blocking the invasion of bacteria and harmful substances, forming a "physical barrier." Simultaneously, this membrane structure promotes platelet aggregation and accelerates the coagulation process, achieving rapid hemostasis.

[0032] This invention utilizes a nano-scale atomizing nozzle design to control the particle size of the care solution to approximately 0.3 μm, allowing it to penetrate deep into the basal layer of the skin (>200 μm), thereby increasing the bioavailability of the active ingredients. Metasilicic acid activates skin fibroblasts, promoting collagen and elastin synthesis, and thus enhancing the skin's ability to repair itself.

[0033] The silica in this invention activates macrophages, NK cells, and T lymphocytes, improving the body's ability to recognize and eliminate viruses (especially HPV), while also reducing the release of inflammatory factors and alleviating local immune stress responses. Combined with other traditional Chinese medicine ingredients such as astragalus, licorice, and ginseng, it helps strengthen the skin's local immune barrier and reduce the risk of persistent HPV infection.

[0034] The Chinese herbal compound extract of the present invention contains rich natural active ingredients such as flavonoids, saponins, volatile oils, etc., and has multiple functions such as antibacterial, anti-inflammatory, analgesic, and antioxidant. It cooperates with silicon to play an overall conditioning effect, realizing a closed-loop process from "sterilization" to "repair" to "immune protection".

[0035] The antibacterial care solution described in the present invention, through the above-mentioned technical principles, has demonstrated the following significant technical effects in clinical simulations or user tests: a silicic acid film can be formed on the bleeding wound within 30 seconds after spraying, achieving rapid hemostasis and temporary closure, which is significantly better than traditional alcohol or single Chinese medicine preparations, and is particularly suitable for use in emergency trauma scenarios.

[0036] The silicon antibacterial care solution provided by the present invention significantly improves the comprehensive performance of the product in terms of rapid hemostasis, broad-spectrum antibacterial, wound repair and immune regulation through the synergistic effect of metasilicic acid and a variety of natural plant extracts. After spraying, the product can quickly form a protective film on the wound surface, achieving hemostasis within 30 seconds, and exhibits an antibacterial rate of more than 92% against 12 pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. Experiments have shown that the care solution can increase the wound repair speed by more than 37%, and at the same time has the functions of maintaining the balance of skin microecology, regulating immune function, and assisting in the intervention of HPV infection. It has good safety and wide applicability, and is significantly superior to existing single-function antibacterial products. DETAILED DESCRIPTION

[0037] Example 1

[0038] This embodiment provides a silicon antibacterial solution mainly used for skin wound repair, hemostasis, antibacterial and inflammation control.

[0039] The care solution of this embodiment is composed of the following components in mass percentage: 0.27% metasilicic acid, 0.005% sodium ion, 0.001% calcium ion, 2% angelica extract, 2% safflower extract, 2% liquorice extract, 3% notopterygium root extract, 2% radix polygoni multiflori extract, 2% Panax notoginseng extract, 20% ethanol (75% concentration), and the balance is deionized water to 100%.

[0040] The preparation method of this embodiment is as follows: first, ethanol and deionized water are mixed in proportion to form a basic solvent system; then, the metasilicic acid mother liquor is slowly added under stirring conditions to ensure that it is evenly dispersed in the solution; then, sodium ion and calcium ion solutions are added in sequence to maintain the pH value of the system at about 7.5; then, the above-mentioned plant extracts are added to the mixed solution in sequence, and stirring is continued at room temperature for 1 hour to ensure sufficient fusion; then, the mixture is filtered through a sterile filter membrane with a pore size of 0.22 microns to remove impurities and bacteria; finally, the filtered finished liquid is divided into 20 ml medical ampoules and packaged using a self-pressurized method to obtain the multifunctional skin care solution described in this embodiment.

[0041] The results of use show that when this embodiment is applied to simulate mild skin trauma, it can achieve rapid hemostasis within 30 seconds and significantly promote wound repair within 48 hours. The area of ​​wound redness and swelling is reduced by an average of 47%, and no obvious skin irritation reaction is observed. It is suitable for a variety of trauma care scenarios.

[0042] Example 2

[0043] This embodiment provides an antibacterial care solution for the care of the skin and mucous membranes around the female vulva, perineum and vagina, which has the functions of antibacterial, repairing, regulating microecology and assisting in the intervention of HPV infection.

[0044] The care solution of this embodiment is composed of the following components in mass percentage: 0.25% metasilicic acid, 0.01% sodium ion, 0.005% calcium ion, 1% astragalus extract, 1% wormwood extract, 2% licorice extract, 2% acanthopanax cortex extract, 2% eucommia extract, 0.003% Changbai Mountain ginseng extract, 15% ethanol (70% concentration), and the balance is deionized water to 100%.

[0045] The preparation method of this embodiment is as follows: first, a basic ethanol solution is prepared, and the ethanol concentration is controlled to be 70%; then, a metasilicic acid mother liquor and a sodium and calcium ion buffer system are sequentially added thereto, stirred evenly, and the pH value of the system is adjusted to between 7.2 and 7.8; then, the various plant extracts and ginseng extract are added in sequence, and stirring is continued for 1 hour to ensure dissolution and uniform distribution; then, precision filtration is performed using a 0.22-micron microporous membrane to remove particulates and bacteria; finally, the resulting liquid is filled into a 20 ml medical ampoule spray bottle and packaged using low-pressure self-pressurization technology.

[0046] The results of in vitro microbial experiments show that when used in a vulvar skin model simulating HPV infection, the care solution can significantly increase the mucosal repair rate (up to 42%) after continuous use for 7 days, significantly relieve discomfort symptoms such as itching, redness, swelling, and odor, and promote the stabilization of vaginal flora. No adverse reactions were observed during use, and it has good potential for private care and auxiliary treatment.

[0047] After professional testing, this embodiment has a significant inhibitory effect on 12 common pathogens such as Staphylococcus aureus, Escherichia coli, Candida albicans, and Propionibacterium acnes, with an inhibition rate of more than 92%, and is suitable for a variety of skin infection prevention and care scenarios. The results of the national test report show that the care solution can increase the wound healing speed by more than 37%, significantly reduce the redness, swelling, exudation and other phenomena during the healing process, and reduce scars after healing. Compared with traditional antibacterial sprays, the product of the present invention can maintain an effective antibacterial effect on the skin surface for 3 to 4 hours, does not interfere with the normal skin microecology, and has high safety. The private care and HPV auxiliary prevention and treatment effects are significant. After 7 days of use in the female private area, clinical feedback shows that: itching, odor, and redness are significantly relieved; the mucosal repair rate is increased by 42%; the flora structure is well restored, and it helps reduce the persistence rate of HPV infection, and has good auxiliary intervention value.

[0048] It adopts medical-grade ampoule packaging and self-pressurized nozzle design, which is easy to carry and spray accurately; it is suitable for people of all ages, and can be used safely by mothers and babies, people with sensitive skin and athletes.

[0049] The above description is only used to illustrate the technical solution of the present invention and is not intended to limit it. Other modifications or equivalent substitutions made to the technical solution of the present invention by ordinary technicians in this field should be included in the scope of the claims of the present invention as long as they do not depart from the spirit and scope of the technical solution of the present invention.

Claims

1. A multifunctional antibacterial care solution containing silicon, characterized by: It contains the following components by mass percentage: Metasilicic acid (H2SiO3): 0.25%–0.28% (2500–2800 ppm); Sodium ions (Na + ):0.002%–0.01%; calcium ion (Ca 2+ ): 0.00016%–0.00075%; ginseng extract: 0.003%; natural plant extract blend: 20%–30%; ethanol: 70%–80%; the balance is deionized water: the total amount is adjusted to 100%.

2. A multifunctional antibacterial care solution containing silicon according to claim 1, characterized in that: The natural plant extracts include but are not limited to Chinese herbal medicines such as angelica, astragalus, liquorice, mugwort, safflower, notopterygium wilfordii, angelica pubescens, acanthopanax bark, radix polygoni avicularis, eucommia bark, and Panax notoginseng. The plant extracts are all prepared by water extraction, alcohol extraction, or supercritical extraction.

3. A method for preparing a multifunctional antibacterial care solution containing silicon, characterized in that: Mix ethanol and deionized water to form a base solvent; add metasilicic acid mother liquor and stir evenly; add sodium calcium ion buffer to maintain the pH value at about 7.5; add the above plant extracts to the mixed solution respectively, stir at room temperature for 60 minutes; filter through a 0.22 μm sterile filter; fill into medical ampoules, and seal with self-pressurization.

4. The multifunctional antibacterial care solution containing silicon according to claim 1, characterized in that: It contains the following ingredients in percentage by mass: 0.27% of metasilicic acid, 0.005% of sodium ions, 0.001% of calcium ions, 2% of angelica extract, 2% of safflower extract, 2% of liquorice extract, 3% of notopterygium wilfordii extract, 2% of radix polygoni aviculare extract, 2% of notoginseng extract, 20% of ethanol (75% concentration), and the balance is made up to 100% with deionized water.

5. The multifunctional antibacterial care solution containing silicon according to claim 4, characterized in that: The preparation method of the care solution is as follows: first, ethanol and deionized water are mixed in proportion to form a basic solvent system; then, metasilicic acid mother liquor is slowly added under stirring conditions to ensure that it is evenly dispersed in the solution; then, sodium ion and calcium ion solutions are added in sequence to maintain the pH value of the system at about 7.5; then, the above-mentioned plant extracts are added to the mixed solution in sequence, and stirring is continued at room temperature for 1 hour to ensure full fusion; then, the mixture is filtered through a sterile filter membrane with a pore size of 0.22 microns to remove impurities and bacteria; finally, the filtered finished liquid is divided into 20 ml medical ampoules and packaged in a self-pressurized manner to obtain the multifunctional skin care solution described in this embodiment.

6. The multifunctional antibacterial care solution containing silicon according to claim 1, characterized in that: The care solution of this embodiment is composed of the following components in mass percentage: 0.25% metasilicic acid, 0.01% sodium ion, 0.005% calcium ion, 1% astragalus extract, 1% wormwood extract, 2% licorice extract, 2% acanthopanax cortex extract, 2% eucommia extract, 0.003% ginseng extract, 15% ethanol (70% concentration), and the balance is deionized water to 100%.

7. The multifunctional antibacterial care solution containing silicon according to claim 6, characterized in that: The preparation method of the care solution is as follows: the preparation method of this embodiment is as follows: first, a basic ethanol solution is prepared, and the ethanol concentration is controlled to 70%; on this basis, metasilicic acid mother liquor and sodium and calcium ion buffer systems are added in sequence, stirred evenly, and the pH value of the system is adjusted to between 7.2 and 7.8; then, various plant extracts and ginseng extracts are added in sequence, and stirring is continued for 1 hour to ensure dissolution and uniform distribution; then, a 0.22-micron microporous membrane is used for precision filtration to remove particles and miscellaneous bacteria; finally, the resulting liquid is filled into a 20 ml medical ampoule spray bottle, and low-pressure self-pressurization technology is used to complete the packaging.