Pharmaceutical composition for effectively improving cough and hemoptysis symptoms as well as preparation method and application thereof

Abstract

The invention discloses a pharmaceutical composition for effectively improving cough and hemoptysis symptoms as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The pharmaceutical composition comprises reddish orange, sambucus chinensis, honey-fried radix stemonae, sugarcane juice-fried selfheal, rock candy and pork, and the preparation method comprises the following steps: S1, weighing the reddish orange, the sambucus chinensis, the honey-fried radix stemonae, the sugarcane juice-fried selfheal, the rock candy and the pork in parts by weight, and then dicing the reddish orange; the method comprises the following steps: adding water to boil to be soft and rotten, and then fishing out and mashing into paste; cooking the pork, fishing out and dicing; s2, adding the citrus reticulata blanco, the ipomoea batatas and the pork which are treated in the step S1, the radix stemonae roasted with honey, the selfheal roasted with sugarcane juice and the rock candy into a pot, and then adding water to boil the mixture into paste. According to the pharmaceutical composition provided by the invention, various components are scientifically matched to form a synergistic effect, and the pharmaceutical composition has remarkable advantages in improvement of cough and hemoptysis symptoms in bronchitis, bronchiectasia and pulmonary tuberculosis diseases.

Description

Technical Field

[0001] The present invention relates to the field of biomedicine technology, and in particular to a pharmaceutical composition for effectively improving symptoms of cough and hemoptysis, and a preparation method and application thereof. Background Art

[0002] Coughing and coughing up blood are common clinical symptoms, which are often seen in diseases such as bronchitis, bronchiectasis and tuberculosis. They not only seriously affect the patient's quality of life, but may also cause other complications.

[0003] Drugs used to treat coughs and hemoptysis are mostly chemically synthesized. While these drugs can alleviate symptoms to a certain extent, they have significant side effects and are prone to drug resistance. For example, in the treatment of bronchitis or bronchiectasis, salbutamol may cause palpitations, tachycardia, headaches, dizziness, nausea, and vomiting; aminophylline may cause nausea, vomiting, stomach discomfort, headaches, dizziness, insomnia, irritability, arrhythmias, and low blood pressure. In the treatment of tuberculosis, isoniazid may cause peripheral neuritis and liver damage; rifampicin may cause hepatotoxicity and allergic reactions; pyrazinamide may cause hyperuricemia and joint pain; and ethambutol may cause optic neuritis, resulting in decreased vision and visual field defects.

[0004] In addition, long-term use of the above-mentioned chemical drugs, in addition to the above-mentioned adverse reactions, may also cause damage to the patient's liver and kidney functions and lead to more serious diseases.

[0005] Although there are Chinese herbal preparations currently on the market for treating cough and hemoptysis symptoms, some of them have problems such as single formula and unsatisfactory therapeutic effect, making it difficult to comprehensively take into account the treatment of cough and hemoptysis symptoms.

[0006] Based on this, how to develop a pharmaceutical composition with few side effects and significant efficacy for improving cough and hemoptysis symptoms has important clinical significance. Summary of the Invention

[0007] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a pharmaceutical composition that effectively improves the symptoms of cough and hemoptysis. The pharmaceutical composition, through the scientific combination of multiple ingredients, forms a synergistic effect and plays a very significant role in improving the symptoms of cough and hemoptysis caused by bronchitis, bronchiectasis and pulmonary tuberculosis.

[0008] The object of the present invention is achieved through the following technical solutions:

[0009] A pharmaceutical composition for effectively improving symptoms of cough and hemoptysis, comprising the following components:

[0010] Tangerine peel, saw vine, honey-roasted Stemona tuberosa, sugarcane juice-roasted Prunella vulgaris, rock sugar and pork.

[0011] Preferably, the pharmaceutical composition comprises the following components in parts by weight:

[0012] 45-55 parts of tangerine peel, 15-22 parts of saw vine, 18-25 parts of honey-roasted stemonae, 18-25 parts of sugarcane juice-roasted prunella vulgaris, 180-250 parts of rock sugar, and 450-550 parts of pork.

[0013] Preferably, the pharmaceutical composition comprises the following components in parts by weight:

[0014] 48-53 parts of tangerine peel, 16-20 parts of saw vine, 20-22 parts of honey-roasted stemonae, 18-23 parts of sugarcane juice-roasted prunella vulgaris, 200-230 parts of rock sugar, and 485-510 parts of pork.

[0015] Preferably, the pharmaceutical composition comprises the following components in parts by weight:

[0016] 50 parts of tangerine peel, 20 parts of saw vine, 20 parts of honey-roasted Stemona, 20 parts of sugarcane juice-roasted Prunella vulgaris, 200 parts of rock sugar, and 500 parts of pork.

[0017] Preferably, the pork is pork belly; the pharmaceutical composition further comprises hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice roasted honeysuckle.

[0018] Preferably, the pharmaceutical composition further comprises 5 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 10 to 15 parts of sugarcane juice-roasted honeysuckle.

[0019] Preferably, the pharmaceutical composition further comprises 8 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 12 to 15 parts of sugarcane juice-roasted honeysuckle.

[0020] In addition, to achieve the above object, the present invention also provides a method for preparing a pharmaceutical composition, comprising the following steps:

[0021] S1. Weigh by weight tangerine peel, saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar and pork, followed by tangerine peel, saw vine and pork were treated as follows:

[0022] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it;

[0023] S2. Add the processed tangerine peel, saw-saw vine and pork in S1, as well as the first mixture consisting of honey-roasted stemonae, sugarcane juice-roasted selfheal and rock sugar to the pot, and then add 3 to 5 times the total mass of the first mixture of water and boil until it becomes a paste.

[0024] In addition, to achieve the above object, the present invention further provides a method for preparing a pharmaceutical composition, comprising the following steps:

[0025] S1. Weigh by weight tangerine peel, saw saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar, pork, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-fried honeysuckle, followed by tangerine peel, saw saw vine and pork were treated as follows:

[0026] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it;

[0027] S2. Add the processed tangerine peel, saw vine and pork in S1, as well as the second mixture consisting of honey-roasted Stemona, sugarcane juice-roasted Prunella Vulgaris, crystal sugar, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle to the pot, and then add 3 to 5 times the total mass of the second mixture of water and boil until it becomes a paste.

[0028] In addition, to achieve the above-mentioned purpose, the present invention provides the use of the pharmaceutical composition in the preparation of a drug for improving cough and hemoptysis diseases, wherein the cough and hemoptysis diseases are any one or more of bronchitis, bronchiectasis and pulmonary tuberculosis.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] 1. The pharmaceutical composition provided by the present invention, through the scientific combination of multiple ingredients (tangerine peel, serrata serrata, honey-roasted stemonae, sugarcane juice-roasted prunella vulgaris, crystal sugar, and pork), forms a synergistic effect and shows significant advantages in improving the cough and hemoptysis symptoms of bronchitis, bronchiectasis, and pulmonary tuberculosis. At the same time, all ingredients in the pharmaceutical composition provided by the present invention are natural ingredients. Compared with chemically synthesized drugs, the probability of drug side effects is greatly reduced, the drug safety is improved, and it is more suitable for long-term use.

[0031] 2. The present invention, by adding hydroxypropyltrimethylammonium chloride chitosan, can effectively absorb the oil in the decoction, thereby reducing the greasy taste of the decoction; at the same time, hydroxypropyltrimethylammonium chloride chitosan has good film-forming properties, antibacterial properties and certain antioxidant properties, can effectively slow down the oxidation of decoction components, and effectively inhibit microbial growth, thereby effectively extending the shelf life of the decoction. In addition, hydroxypropyltrimethylammonium chloride chitosan can form a protective film on the surface of the respiratory mucosa, reduce the irritation of the drug components, and effectively reduce the frequency of coughs to a certain extent.

[0032] Adding sugarcane juice to roasted honeysuckle enhances its yin-nourishing and moistening properties, further clearing heat and toxins from the body, alleviating respiratory inflammation and effectively relieving coughs and hemoptysis. Furthermore, it enhances the antibacterial effects of the decoction, while also reducing its greasy feel, based on the hydroxypropyltrimethylammonium chloride chitosan.

[0033] In summary, by adding hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice roasted honeysuckle, the greasy feeling of the decoction can be effectively reduced, and the patient's acceptance of the medicine can be improved; the growth of microorganisms and the oxidation of components can be effectively inhibited, and the shelf life of the decoction can be effectively extended; and the effect of the pharmaceutical composition on improving cough and hemoptysis can be further improved. DETAILED DESCRIPTION

[0034] A pharmaceutical composition for effectively improving symptoms of cough and hemoptysis, comprising the following components:

[0035] Tangerine peel, saw vine, honey-roasted Stemona tuberosa, sugarcane juice-roasted Prunella vulgaris, rock sugar and pork.

[0036] In the above scheme, the functions of each component are as follows:

[0037] Tangerine peel: warm in nature, pungent and bitter in taste, enters the lung and spleen meridians, has the effects of regulating qi, relieving fullness, drying dampness and resolving phlegm, can effectively relieve cough and sputum symptoms caused by phlegm and dampness blocking the lungs, reduce airway obstruction and improve respiratory function.

[0038] Saw-saw vine: It is cool in nature, pungent and bitter in taste, and has the effects of clearing away heat and detoxifying, reducing swelling and relieving pain. It has a certain inhibitory effect on respiratory tract inflammation, can reduce inflammatory response, and relieve symptoms of cough and hemoptysis.

[0039] Honey-roasted Stemona: Stemona is slightly warm in nature, sweet and bitter in taste. After being roasted with honey, its lung-moistening and cough-relieving effects are enhanced. It can directly act on the respiratory tract, inhibit the cough center, and relieve cough symptoms. At the same time, it has a certain inhibitory effect on pathogens that cause respiratory infections.

[0040] Roasted Prunella Vulgaris with Sugarcane Juice: Prunella Vulgaris is cold in nature, with a pungent and bitter taste. It has the effects of clearing the liver and purging heat, dispersing nodules and reducing swelling. However, prolonged use can easily damage the spleen and stomach's yang energy, leading to spleen and stomach deficiency and cold, and symptoms such as abdominal pain, diarrhea, and loss of appetite. Roasting it with sugarcane juice alleviates its coldness and enhances its yin-nourishing and moistening effects, effectively preventing damage to the patient's spleen and stomach yang energy and the resulting spleen and stomach deficiency and cold. It also enhances its liver-clearing and purging heat, dispersing nodules and reducing swelling, effectively alleviating coughs and hemoptysis caused by intense lung heat, and nourishing and repairing lung tissue. Furthermore, it also reduces the bitterness of Prunella Vulgaris, improving its taste.

[0041] Rock sugar: sweet in taste, neutral in nature, has the effect of moistening the lungs and promoting salivation. It not only improves the taste of the medicinal composition, but also synergizes with other drugs to enhance the effect of moistening the lungs and relieving cough.

[0042] Pork: It plays the role of harmonizing various medicines in prescriptions. It is also rich in nutrients and can provide the human body with protein, fat, minerals, etc. It can replenish the nutrients consumed by patients due to illness, enhance the body's resistance, and promote physical recovery.

[0043] The pharmaceutical composition provided by this invention, through the scientific combination of multiple ingredients, creates a synergistic effect, demonstrating significant advantages in alleviating cough and hemoptysis symptoms associated with bronchitis, bronchiectasis, and pulmonary tuberculosis. Furthermore, the raw materials provided by this invention are all natural, significantly reducing the likelihood of side effects compared to chemically synthesized drugs, improving medication safety, and making it more suitable for long-term use.

[0044] In order to further improve the effect of the pharmaceutical composition in improving the symptoms of cough and hemoptysis, as some possible embodiments of the present application, the dosage of each component in the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes the following components in parts by weight:

[0045] 45-55 parts of tangerine peel, 15-22 parts of saw vine, 18-25 parts of honey-roasted stemonae, 18-25 parts of sugarcane juice-roasted prunella vulgaris, 180-250 parts of rock sugar, and 450-550 parts of pork.

[0046] In order to further improve the effect of the pharmaceutical composition in improving the symptoms of cough and hemoptysis, as some possible embodiments of the present application, the dosage of each component in the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes the following components in parts by weight:

[0047] 48-53 parts of tangerine peel, 16-20 parts of saw vine, 20-22 parts of honey-roasted stemonae, 18-23 parts of sugarcane juice-roasted prunella vulgaris, 200-230 parts of rock sugar, and 485-510 parts of pork.

[0048] In order to further improve the effect of the pharmaceutical composition in improving the symptoms of cough and hemoptysis, as some possible embodiments of the present application, the dosage of each component in the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes the following components in parts by weight:

[0049] 50 parts of tangerine peel, 20 parts of saw vine, 20 parts of honey-roasted Stemona, 20 parts of sugarcane juice-roasted Prunella vulgaris, 200 parts of rock sugar, and 500 parts of pork.

[0050] Pharmaceutical composition of the present invention, when actually taken, adopts the form of boiling into decoction and takes, because containing nutritious materials such as pork, crystal sugar in pharmaceutical composition, for the growth and reproduction of microorganisms provides good living environment, is easy to microbial growth, therefore, decoction is very easy to spoil, as the phenomena such as peculiar smell, discoloration occur.Therefore, in order to guarantee the drug effect of decoction to the greatest extent, it is necessary to ensure that it is taken when not deteriorating.After testing, decoction in the present invention, when actually preserved, under refrigerated sealing condition, storage time is no more than 3 days, so storage time is relatively short.But the time that decoction is boiled at every turn is longer, if the decoction storage time is short, then the frequency of patient boiling decoction is increased, increases the cumbersomeness and the inconvenience of medication.

[0051] In addition, the pork of the present invention uses pork belly, which contains a certain amount of fat. After being boiled into a decoction, it has a certain greasy taste and oily smell. For some patients who do not like oil, it is relatively difficult to take the medicine. After taking the medicine, the greasy feeling spreads in the mouth and throat, increasing the patient's discomfort and nausea, which may further aggravate coughing.

[0052] Based on this, in order to further improve the shelf life of the pharmaceutical composition, reduce the greasy taste of the pharmaceutical composition, and improve the cough and hemostasis effect, as some feasible embodiments of the present application, the type of pharmaceutical composition is further limited, that is, the pharmaceutical composition also includes hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice roasted honeysuckle.

[0053] Hydroxypropyltrimethylammonium chloride chitosan has the following effects:

[0054] ① Hydroxypropyltrimethylammonium chloride chitosan has an amphiphilic structure. The cationic groups in its molecules can bind to the anionic groups or polar groups on the surface of oil molecules through electrostatic attraction. The hydrophobic part can interact with the oil molecules through hydrophobic interaction. At the same time, the molecular chain can fix the oil molecules in its network structure through entanglement and wrapping, thereby achieving oil adsorption. When hydroxypropyltrimethylammonium chloride chitosan is added to the decoction, it will undergo the above-mentioned interaction with the oil in the decoction, adsorbing some of the oil, reducing the free oil in the decoction, and thus reducing the greasy taste of the decoction.

[0055] ② Hydroxypropyltrimethylammonium chloride chitosan has good film-forming and antibacterial properties (anti-Staphylococcus aureus, Escherichia coli, Candida albicans, Salmonella, etc.), and can form a protective film on the surface of the decoction to prevent air from contacting the ingredients in the decoction, slowing down the oxidation of the decoction components (such as inhibiting the oxidation of decoction oils and flavonoids in sugarcane juice and roasted summer cypress, etc.), helping to maintain the freshness and efficacy of the decoction. At the same time, it has the effect of inhibiting the growth of microorganisms and can effectively extend the shelf life of the decoction.

[0056] ③ Bronchitis, bronchiectasis and pulmonary tuberculosis will cause long-term frequent and severe coughing, which will cause repeated vibration and impact of the respiratory mucosa, leading to damage to the respiratory mucosa. Hydroxypropyltrimethylammonium chloride chitosan can form a protective film on the surface of the respiratory mucosa, reduce external stimulation, and help repair damaged respiratory mucosal tissue, which can effectively reduce the frequency of coughing to a certain extent.

[0057] Honeysuckle flower roasted with sugarcane juice has the following benefits: Honeysuckle flower has the effects of clearing heat and detoxifying, and dispersing wind-heat. After being roasted with sugarcane juice, its yin-nourishing and moistening effects are enhanced, further clearing heat and toxins from the body, alleviating respiratory inflammation, and relieving cough and hemoptysis symptoms. In addition, its chlorogenic acid and other ingredients have certain antibacterial effects, inhibiting the growth of bacteria that may be present in decoctions based on hydroxypropyltrimonium chloride chitosan. At the same time, its refreshing fragrance can further reduce the greasy feeling of the decoction.

[0058] In summary, the present invention, by adding hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-fried honeysuckle, can effectively reduce the greasy feeling of the decoction and improve patients' acceptance of the medicine. It can also inhibit microbial growth and component oxidation, effectively extending the shelf life of the decoction and reducing the frequency of patients' decoction. Furthermore, it can further enhance the effectiveness of the pharmaceutical composition in alleviating cough and hemoptysis.

[0059] In order to further improve the shelf life of the pharmaceutical composition, reduce the greasy taste and oily smell of the pharmaceutical composition, and improve the antitussive and hemostatic effects, as some feasible embodiments of the present application, the dosage of hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice roasted honeysuckle is further limited, that is, the pharmaceutical composition also includes 5 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 10 to 15 parts of sugarcane juice roasted honeysuckle.

[0060] In order to further improve the shelf life of the pharmaceutical composition, reduce the greasy taste and oily smell of the pharmaceutical composition, and improve the antitussive and hemostatic effects, as some feasible embodiments of the present application, the dosage of hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice roasted honeysuckle is further limited, that is, the pharmaceutical composition also includes 8 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 12 to 15 parts of sugarcane juice roasted honeysuckle.

[0061] In addition, the present invention provides a method for preparing a pharmaceutical composition, comprising the following steps:

[0062] S1. Weigh by weight tangerine peel, saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar and pork, followed by tangerine peel, saw vine and pork were treated as follows:

[0063] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it;

[0064] S2. Add the processed tangerine peel, saw-saw vine and pork in S1, as well as the first mixture consisting of honey-roasted stemonae, sugarcane juice-roasted selfheal and rock sugar to the pot, and then add 3 to 5 times the total mass of the first mixture of water and boil until it becomes a paste.

[0065] The above-mentioned entire process mainly includes steps such as raw material processing, mixing and boiling. It does not require complicated equipment and technology, is easy to master and operate, and effectively saves costs.

[0066] In addition, the present invention further provides a method for preparing a pharmaceutical composition, comprising the following steps:

[0067] S1. Weigh by weight tangerine peel, saw saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar, pork, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-fried honeysuckle, followed by tangerine peel, saw saw vine and pork were treated as follows:

[0068] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it;

[0069] S2. Add the processed tangerine peel, saw vine and pork in S1, as well as the second mixture consisting of honey-roasted Stemona, sugarcane juice-roasted Prunella Vulgaris, crystal sugar, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle to the pot, and then add 3 to 5 times the total mass of the second mixture of water and boil until it becomes a paste.

[0070] Furthermore, the present invention provides the use of the pharmaceutical composition in the preparation of a drug for improving cough and hemoptysis, wherein the cough and hemoptysis diseases are any one or more of bronchitis, bronchiectasis and pulmonary tuberculosis.

[0071] The preparation of the pharmaceutical composition described in this application is further described in detail below in conjunction with specific embodiments.

[0072] Example 1

[0073] S1. Weigh 53g of dried tangerine peel, 18g of Rhizoma Serratae, 20g of honey-roasted Stemona radix, 18g of Rhizoma Scutellariae with sugarcane juice, 200g of rock sugar, and 505g of pork belly (fat-to-lean ratio of 1:1). Then, process the dried tangerine peel, Rhizoma Serratae, and pork as follows:

[0074] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it (length, width and height should all be less than 0.5 cm);

[0075] S2. The first mixture of the processed tangerine peel, saw saw vine and pork in S1, as well as the honey-fried stemonae, sugarcane juice-fried selfheal and rock sugar was added to the pot, followed by adding 3000g of water and simmering it over low heat until it became a paste of 1000ml, which was then passed through a 20-mesh sieve.

[0076] Among them, the preparation method of honey-roasted Stemona bud is as follows: take a certain amount of honey, pour it into a pot and add appropriate amount of water, heat it on low heat and stir it constantly, wait until the honey is heated to light yellow, and when it is picked up with chopsticks, the honey flows down in a line, and the dripping honey can quickly condense into beads in cold water, and the honey refining is completed; add dry Stemona bud slices 4 times the mass of honey (thickness less than 0.2mm, length and width less than 0.5mm) into the refined honey, stir evenly, then place the pot on low heat, slowly heat and stir-fry while constantly turning the Stemona bud, stop heating when the surface of the Stemona bud is dark yellow and the texture is crispy, and wait for it to cool to obtain the honey-roasted Stemona bud.

[0077] The preparation method of sugarcane juice-roasted selfheal is as follows: fresh sugarcane juice and dried and cut selfheal (length less than 0.5 cm, mass ratio of sugarcane juice to selfheal of 3:5) are added into a pot, mixed thoroughly, left to stand for half an hour, then heated over low heat with continuous stirring until the sugarcane juice is completely absorbed by the selfheal, and then the selfheal is taken out and dried at low temperature to obtain sugarcane juice-roasted selfheal.

[0078] Example 2

[0079] On the basis of Example 1, the quality of tangerine peel, serrata serrata, honey-roasted stemonae, sugarcane juice-roasted prunella vulgaris, crystal sugar and pork belly was adjusted, and the quality after adjustment was as follows:

[0080] 50g of tangerine peel, 20g of saw vine, 20g of honey-roasted Stemona, 20g of sugarcane juice-roasted Prunella Vulgaris, 200g of rock sugar and 500g of pork.

[0081] The remaining steps and parameters are the same as those in Example 1.

[0082] Example 3

[0083] S1. Weigh 53g of dried tangerine peel, 18g of serrata serrata, 20g of honey-roasted radix stemonae, 18g of sugarcane juice-roasted herba scutellariae, 200g of crystal sugar, 505g of pork belly (fat-to-lean ratio of 1:1), 10g of hydroxypropyltrimethylammonium chloride chitosan, and 14g of sugarcane juice-roasted honeysuckle. Then, the dried tangerine peel, serrata serrata, and pork were processed as follows:

[0084] Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it (length, width and height should all be less than 0.5 cm);

[0085] S2. Add the dried tangerine peel, saw vine and pork processed in S1, as well as honey-roasted Stemona, sugarcane juice-roasted Prunella Vulgaris, crystal sugar, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle to the pot, followed by 3000g of water and simmering over low heat until the paste reaches 1000ml, which is then passed through a 20-mesh sieve.

[0086] Wherein, the method of roasting Stemona tuberosa with honey and roasting Prunella vulgaris with sugarcane juice is the same as that in Example 1.

[0087] The preparation method of sugarcane juice roasted honeysuckle is as follows: add fresh sugarcane juice and dried honeysuckle (dried honeysuckle is obtained by low-temperature drying fresh honeysuckle, and the mass ratio of dried honeysuckle to sugarcane juice is 1:1) into a pot, mix well, let it stand for 1 hour, then heat it over low heat and stir continuously until the sugarcane juice is completely absorbed by the honeysuckle, then take out the honeysuckle and dry it at low temperature to obtain sugarcane juice roasted honeysuckle.

[0088] Comparative Example 1

[0089] Compared with Example 1, pork is not added to the pharmaceutical composition, and the remaining components and dosages are the same as in Example 1.

[0090] Comparative Example 2

[0091] Compared with Example 3, honeysuckle is not added to the pharmaceutical composition, and the remaining components and dosages are the same as in Example 1.

[0092] Comparative Example 3

[0093] Compared with Example 3, hydroxypropyltrimethylammonium chloride chitosan is not added to the pharmaceutical composition, and the remaining components and amounts are the same as those in Example 1.

[0094] 1. Clinical Trials

[0095] 1. Subject screening

[0096] A total of 100 subjects (all aged over 18 years old) with a course of disease of more than 3 months were divided into 5 groups, namely, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group and control group. There was no significant difference in the general information of the patients in each group, and they were comparable.

[0097] The inclusion criteria for the subjects were: persons diagnosed with pulmonary tuberculosis by imaging examination, laboratory examination (sputum smear examination, sputum culture, etc.) or pathological examination and who had symptoms of coughing and coughing with blood.

[0098] Exclusion criteria were: ① patients with malignant tumors; ② pregnant or lactating women; ③ patients with respiratory infections; ④ patients with coughs induced by other causes; ⑤ patients with mental illness or cognitive impairment; ⑥ patients with serious heart, lung, liver, or kidney diseases.

[0099] 2. Medication

[0100] The patients in the Example 1 group took the decoction prepared in Example 1, 50 ml each time, 3 times a day.

[0101] The patients in the Example 2 group took the decoction prepared in Example 2, 50 ml each time, 3 times a day.

[0102] The patients in the Example 3 group took the decoction prepared in Example 3, 50 ml each time, 3 times a day.

[0103] The comparative example 1 group took the decoction prepared in comparative example 1, 50 ml each time, 3 times a day.

[0104] The control group took Yuehua Pills twice a day, one pill each time.

[0105] 3. Criteria for determining efficacy

[0106] Cure: Cough and hemoptysis symptoms completely disappear; no recurrence within 1 year.

[0107] Markedly effective: cough and hemoptysis symptoms were relieved;

[0108] Effective: Only one of the symptoms of cough or hemoptysis improves;

[0109] Ineffective: There was no improvement in cough or hemoptysis symptoms.

[0110] All the patients in the above groups received 3 courses of treatment, with each course lasting 1 month.

[0111] The patient's condition was observed after 3 months. The experimental results are shown in Table 1.

[0112] Table 1:

[0113] Number of people cured Number of people with significant effects Effective number of people Invalid number of people Example 1 group 1 11 5 2 Example 2 group 2 12 4 2 Example 3 group 3 14 2 1 Comparative Example 1 0 6 10 4 control group 0 7 10 3

[0114] As shown in Figure 1, there were patients who were completely cured in all of the groups of Examples 1 to 3, and the number of patients who showed significant effects was greater than 10. In Example 3, after the addition of hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle, the number of patients who were cured and showed significant effects was even greater, indicating that the addition of these two enhanced the hemostatic and antitussive effects of the pharmaceutical composition.

[0115] In the comparative example 1 group, the lack of pork resulted in a significant decrease in the number of patients with significant effects of the pharmaceutical composition, demonstrating the synergistic effect of the pharmaceutical composition of the present invention in stopping bleeding and relieving cough. The control group had a better antitussive effect, but the antitussive and hemostatic effects were inferior to those of the examples 1 to 3 groups.

[0116] The subjects who were cured or significantly effective in Table 1 were required to stop taking the drug for at least three months after three courses of treatment. The number of subjects who relapsed during the three-month period is shown in Table 2. Relapse refers to worsening of either hemoptysis or cough after stopping the drug.

[0117] Table 2:

[0118] Number of cured and effective patients Number of relapses Example 1 group 12 1 Example 2 group 14 1 Example 3 group 17 1 Comparative Example 1 6 3 control group 7 2

[0119] As shown in Table 2, the number of relapses in the groups of Examples 1-3 of the present invention three months after drug withdrawal was less than that in the control group and the comparative example 1 group, indicating that the present invention has a more significant therapeutic effect in improving cough and hemostasis.

[0120] 2. The shelf life of decoctions.

[0121] The shelf life of the decoctions prepared in Examples 1 to 3 and Comparative Examples 2 to 3 is shown in Table 3.

[0122] The shelf life is determined by conventional detection methods such as vision (such as the occurrence of delamination), smell (such as the occurrence of sour, rancid, and rotten smells), taste (such as the occurrence of sourness), and viscosity. The judgment is made every 1 hour. If any indicator is abnormal, the period between this time and the initial detection time is deemed to be the shelf life of the present invention (Note: the shelf life in the present invention is only for observing the general shelf life of the decoction).

[0123] Table 3:

[0124] Shelf life (h) Example 1 58 Example 2 61 Example 3 145 Comparative Example 2 92 Comparative Example 3 70

[0125] It can be seen from Table 3 that after adding hydroxypropyl trimethyl ammonium chloride chitosan and sugarcane juice roasted honeysuckle in Example 3, the shelf life was significantly improved. After adding hydroxypropyl trimethyl ammonium chloride chitosan or sugarcane juice roasted honeysuckle in Comparative Examples 2 and 3, although the shelf life was improved to a certain extent, the overall improvement effect was not very significant.

Claims

1. A pharmaceutical composition for effectively improving symptoms of cough and hemoptysis, characterized in that: Includes the following components: Tangerine peel, saw vine, honey-roasted Stemona bulbs, sugarcane juice-roasted Prunella vulgaris, rock sugar and pork.

2. A pharmaceutical composition for effectively improving cough and hemoptysis symptoms according to claim 1, characterized in that: It comprises the following components in parts by weight: 45-55 parts of tangerine peel, 15-22 parts of saw vine, 18-25 parts of honey-roasted stemonae, 18-25 parts of sugarcane juice-roasted prunella vulgaris, 180-250 parts of rock sugar, and 450-550 parts of pork.

3. A pharmaceutical composition for effectively improving cough and hemoptysis symptoms according to claim 2, characterized in that: It comprises the following components in parts by weight: 48-53 parts of tangerine peel, 16-20 parts of saw vine, 20-22 parts of honey-roasted stemonae, 18-23 parts of sugarcane juice-roasted prunella vulgaris, 200-230 parts of rock sugar, and 485-510 parts of pork.

4. A pharmaceutical composition for effectively improving cough and hemoptysis symptoms according to claim 2, characterized in that: It comprises the following components in parts by weight: 50 parts of tangerine peel, 20 parts of saw vine, 20 parts of honey-roasted Stemona, 20 parts of sugarcane juice-roasted Prunella vulgaris, 200 parts of rock sugar, and 500 parts of pork.

5. The method for preparing the pharmaceutical composition according to claim 4, wherein The pork is pork belly; the pharmaceutical composition further comprises hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle.

6. The method for preparing the pharmaceutical composition according to claim 5, wherein The pharmaceutical composition further comprises 5 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 10 to 15 parts of sugarcane juice-roasted honeysuckle.

7. The method for preparing the pharmaceutical composition according to claim 6, wherein The pharmaceutical composition further comprises 8 to 10 parts of hydroxypropyltrimethylammonium chloride chitosan and 12 to 15 parts of sugarcane juice-roasted honeysuckle.

8. The method for preparing the pharmaceutical composition according to any one of claims 2 to 4, characterized in that: The steps include: S1. Weigh by weight tangerine peel, saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar and pork, followed by tangerine peel, saw vine and pork were treated as follows: Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it; S2. Add the processed tangerine peel, saw-saw vine and pork in S1, as well as the first mixture consisting of honey-roasted stemonae, sugarcane juice-roasted selfheal and rock sugar to the pot, and then add 3 to 5 times the total mass of the first mixture of water and boil until it becomes a paste.

9. The method for preparing the pharmaceutical composition according to any one of claims 5 to 7, characterized in that: The steps include: S1. Weigh by weight tangerine peel, saw saw vine, honey-fried stemonae, sugarcane juice-fried prunella vulgaris, rock sugar, pork, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-fried honeysuckle, followed by tangerine peel, saw saw vine and pork were treated as follows: Dice the tangerine peel; chop the saw vine and boil it in water until soft, then remove and mash it into a paste; cook the pork, remove and dice it; S2. Add the processed tangerine peel, saw vine and pork in S1, as well as the second mixture consisting of honey-roasted Stemona, sugarcane juice-roasted Prunella Vulgaris, crystal sugar, hydroxypropyltrimethylammonium chloride chitosan and sugarcane juice-roasted honeysuckle to the pot, and then add 3 to 5 times the total mass of the second mixture of water and boil until it becomes a paste.

10. Use of the pharmaceutical composition according to any one of claims 1 to 7 in the preparation of a medicament for improving cough and hemoptysis, characterized in that: The cough and hemoptysis diseases are any one or more of bronchitis, bronchiectasis and pulmonary tuberculosis.